Two-part capsule to accept pharmaceutical preparations for powder inhalers

Abstract

The present invention relates to capsules for holding pharmaceutical preparations for powder inhalers with increased drug safety and capsules for pharmaceutical preparations for powder inhalers with improved adaptation to their use in powder inhalers. The capsules consist of water-insoluble hydrophobic synthetic materials which do not significantly affect the pharmaceutical quality of the contents themselves, but which improve the usability of the filled capsules with regard to their function, their longevity and/or the geographic location of their use, and are advantageous at various stages from manufacture up to utilisation.

Description

[0001] The invention relates to new two-part capsules for holding pharmaceutical preparations for use in powder inhalers.THE PRIOR ART[0002] Capsules with pharmaceutical preparations are often used in the therapy and diagnosis of illnesses. The capsules can be orally administered or are used in certain medical apparatus such as powder inhalers. Generally, the capsules consist of two parts, a capsule body (body) and a capsule cap (cap), which are pushed together telescopically. However, multi-part capsules are also known. The capsules generally consist of gelatine, especially hard gelatine. In the case of some special applications, the capsules occasionally consist of water-soluble synthetic materials easily digested by humans, in order for example to release the active ingredients in certain compartments of the gastrointestinal tract in the case of oral administration. Examples of various capsule materials are listed hereinafter.[0003] EP 0143524 discloses a two-part capsule of mate...

AI Technical Summary

Problems solved by technology

The materials which are used are often not very resistant to air humidity, which is why the pharmaceutical quality of the contents cannot be guaranteed for all climatic zones.

However, these materials are not specially perfected for use in powder inhalers.

Hence materials used in construction of the capsules can alter their characteristics dependent on the ambient air humidity and/or do not always have sufficient inherent stability.

As a result, such a capsule cannot for example be used in climatic zone 4 as a result of the high air humidity, since the capsule material absorbs the humidity to such a degree that the inherent stability is seriously affected and/or the humidity penetrates into the interior of the capsule.

This has a negative effect on the pharmaceu...

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