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3172 results about "Phases of clinical research" patented technology

The phases of clinical research are the steps in which scientists do experiments with a health intervention in an attempt to find enough evidence for a process which would be useful as a medical treatment. In the case of pharmaceutical study, the phases start with drug design and drug discovery then proceed on to animal testing. If this is successful, they begin the clinical phase of development by testing for safety in a few human subjects and expand to test in many study participants to determine if the treatment is effective.

Tissue-specific and pathogen-specific toxic agents and ribozymes

InactiveUS6271359B1Rapidly and effectively expressedVirusesSugar derivativesCancer cellBiology
The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agents to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention also has important implications in the eradication of drug-resistant pathogens and drug-resistant diseased cells (such as cancer cells).
Owner:MUSC FOUND FOR RES DEV +1

Method of measuring cardiac related parameters non-invasively via the lung during spontaneous and controlled ventilation

An apparatus to measure cardiac output (Q) and other parameters such as alveolar ventilation (VA), minute CO2 elimination from the lung (VCO2 ), minute oxygen consumption (VO2), oxygenated mixed venous partial pressure of CO2, (PvCO2-oxy), true mixed venous partial pressure of CO2(PvCO2), PaCO2, mixed venous oxygen saturation (SvO2), pulmonary shunt, and anatomical dead space, consisting of: a) a breathing circuit with characteristics that: i. on exhalation, exhaled gas is kept substantially separate from inhaled gas; ii. oninhalation, when VE is greater than FGS flow, the subject inhales FGS first and then inhales a gas that is substantially SGS, for the balance of inhalation; b) gas sensor means for monitoring gas concentrations at the patient-circuit interface c) a first gas set (FGS), and a second gas set (SGS), said second gas set which may comprise previously exhaled gases or exogenous gases or both d) a gas flow control means for controlling the rate of FGS flow into the breathing circuit e) means to identify phase of breathing, said means may consist of pressure sensors or analysis of signal generated by gas sensors or other means known to those skilled in the art; f) machine intelligence consisting of a computer or logic circuit capable of controlling the gas flow control means, receiving the output of the gas sensor means and means to identify phased of breathing, and performing the calculations for measuring cardiac output and other parameters as outlined in the disclosure.
Owner:THORNHILL SCI INC

System for testing physical model for large-scale landslides under action of multiple factors

The invention discloses a system for testing a physical model for large-scale landslides under the action of multiple factors, which comprises a reservoir level fluctuation simulation unit, a landslide experiment slot section, an artificial rainfall simulation unit and a measuring unit, wherein the landslide experiment slot section comprises a horizontal slot section and a slope slot section, the horizontal slot section and the slope slot section are respectively paved with a slope body consisting of sand-soil mixtures, and the rear end of the horizontal slot section is hinged with the front end of the slope slot section; the slope slot section is composed of more than two slot sections which are sequentially hinged end to end, and the bottom of each slot section is provided with a lifting unit which can adjust the dip angle of the slot section; the rear end of the slope slot section is provided with a Malpighian-tube rear-edge water-replenishing unit; and the measuring unit comprises a deformation measuring part and a stress measuring part, wherein the deformation measuring part is used for measuring the deformation process of the slope body, and the stress measuring part is used for measuring the water pressure and water content of a pore of the slope body. By using the system disclosed by the invention, the changing regularity of each measurable physical quantity of a landslide in different development stages can be grasped accurately, thereby providing a possibility for better developing the studies on key parameters of landslides in different evolution stages.
Owner:INST OF MECHANICS - CHINESE ACAD OF SCI

Attack-oriented network security situation prediction method, device and system

ActiveCN108494810ARealize dynamic associationIn line with the actual environmentData switching networksSecuring communicationCountermeasureAttack graph
The invention belongs to the technical field of network security and particularly relates to an attack-oriented network security situation prediction method, device and system. The method comprises the following steps: detecting and collecting alarm data and network environment operation and maintenance information in a network countermeasure environment, obtaining an element set required by network security situation prediction, wherein the element set comprises three types of information of an attacker, a defense party and a network environment; evaluating the attacker capability and the level of the defense party, establishing a dynamic Bayesian attack graph, and calculating an attack phase number and an attack state occurrence probability vector; and combining a vulnerability scoring standard and network asset information, and performing time-space dimension quantification on the network security situation value. According to the method, dynamic association of the situation elements of the defense party, the attacker, the environment information and the like is achieved, the actual environment of the network is better conformed to, the future situation and the attack occurrencetime can be accurately predicted, higher prediction efficiency is achieved, and storage scale and timeliness of network security situation awareness are optimized, so as to provide more effective guidance for network protection.
Owner:PLA STRATEGIC SUPPORT FORCE INFORMATION ENG UNIV PLA SSF IEU

Micro-ecological traditional Chinese medicine preparation for enhancing immunity of livestock and poultry, and preparation method thereof

The invention provides a micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry, and a preparation method thereof. The invention is characterized in that traditional Chinese medicines are combined with the modern microbial fermentation technology to develop a novel feed additive, i.e. traditional Chinese medicines such as astragalus root, eucommia, licorice, bupleurum and the like are directly fermented by two or more of sporeformer, microzyme, lactobacillus to obtain the product. The micro-ecological traditional Chinese medicine preparation provided by the invention has the efficacies of enhancing the body immunity of livestock and poultry, maintaining the gastrointestinal microbial flora balance of animals, preventing and treating alimentary and respiratory diseases of livestock and poultry, promoting healthy and quick growth of the animals, and improving the qualities of meat, egg and milk; the micro-ecological traditional Chinese medicine preparation has no toxic side effect, no pollution and no residue, can not generate drug resistance, and is suitable for use at each growth stage of the livestock and poultry; and the effect is stable and reliable and can meet the requirements of people for safety in production of livestock and poultry products. The micro-ecological traditional Chinese medicine preparation for enhancing the immunity of livestock and poultry can be increased in dose to be used as a veterinary medicine for application.
Owner:BEIJING KEEPYOUNG TECH
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