1471 results about "Disease cause" patented technology

The invention discloses a liver disease diagnosis and treatment strategy recommendation method based on a knowledge graph, a medium and equipment, and the method comprises the steps: collecting the basic information of a user, constructing a space-time correlated individual liver disease knowledge graph according to the basic information of the user, and enabling the knowledge graph to comprise a disease cause feature node, a pathology grading node, a complication early warning node and a treatment response node which are correlated with each other; inputting the individual hepatopathy knowledge graph into a hierarchical reinforcement learning model for joint reasoning, and outputting multiple groups of strategy options including an antiviral treatment scheme, a liver protection drug combination and a metabolic intervention measure; analyzing a topological propagation path of a complication early warning node through a complication prediction sub-model, and dynamically adjusting an initial candidate diagnosis and treatment strategy set; and updating the individual hepatopathy knowledge graph when obtaining the basic information of the new user. According to the method, multi-dimensional data fusion and dynamic strategy optimization of liver disease diagnosis and treatment are realized, and the accuracy and timeliness of a diagnosis and treatment scheme are remarkably improved.

Methods and kits are provided for diagnosing of neuropsychiatric syndromes concurrent with SLE (NPSLE) and for determining whether an SLE subject is at risk of developing a neuropsychiatric disease.

The invention discloses an acute abdominal pain cause differential diagnosis system based on deep learning, and relates to the technical field of medical artificial intelligence, comprising: a data acquisition module acquires initial self-described text data of a patient; the standardization processing module generates a standardized symptom set through standardization processing; the cause reasoning module performs reasoning according to the standardized symptom set and the medical knowledge graph to obtain a suspected disease set; the contradiction detection module is used for detecting the contradiction between the symptom set and the self-contained text and calculating the contradiction intensity and disease cause relevancy; the priority calculation module ranks contradiction priorities according to contradiction intensity and disease cause relevancy; the contradiction processing module judges the contradiction significance score, if the contradiction significance score is lower than a threshold value, a standardized symptom set is output, and otherwise, an optimal clarification action is generated to solve the contradiction; an iteration updating module updates a symptom set according to clarification action feedback, and causes are inferred again until a termination condition is met; the method can ensure that the pathogenesis reasoning process gradually approaches the real pathogenesis, and improves the diagnosis reliability.

The invention discloses a pest and disease cause and effect relationship identification method and system and a pest and disease cause and effect graph construction method and system. The method comprises the steps of obtaining multi-modal data; preprocessing the multi-modal data, and dividing the preprocessed multi-modal data into sample-level time sequence window data; performing semantic alignment on each time sequence window data, and constructing an event candidate triple; generating a personalized question prompt template according to the context information of the event candidate triad; calling a causal relationship judgment large voice model to execute causal relationship judgment according to the question prompt template to obtain a causal judgment result; wherein the causal judgment result comprises a causal label and confidence; and according to the event candidate triple and the causal judgment result, constructing a disease and pest causal map. The method is beneficial for constructing a disease and pest cause-effect graph with a reasonable structure and differentiated edge classes, and is suitable for digging and identifying a disease and pest cause-effect relationship in a complex agricultural scene.

The invention discloses an intelligent multidisciplinary clinical consultation system and method based on a large language model, and relates to the technical field of medical artificial intelligence. According to the structured consultation suggestion set, the association degree value of the possible disease causes and the consultation departments is calculated in combination with the medical knowledge graph, the departments participating in the consultation are automatically matched, and the consultation sub-targets are determined, so that the problem of lack of interdisciplinary knowledge integration and dynamic coordination ability in the prior art is solved, and the situation that diagnosis and treatment only depend on a single subject is avoided; meanwhile, a multi-disciplinary consultation set is formed by counting the disease cause matching number, calculating the treatment emergency value and the priority index, determining the consultation sequence of consultation departments, obtaining consultation content according to matching of consultation sub-targets and clinical guidelines, and determining the application treatment scheme in combination with patient replies and historical treatment records; according to the process, multidisciplinary knowledge is integrated, comprehensive diagnosis and treatment suggestions are provided for the patient, and the defects of the prior art on a multidisciplinary cooperation overall solution are overcome.

The invention discloses an artificial intelligence auxiliary medical decision-making system, and relates to the technical field of medical assistance. Through the detection suggestion module, preliminary reasoning and observation index judgment can be performed according to patient chief complaint in combination with basic information, and detection suggestions are given in combination with detection cost budget of a patient; through the diagnosis module, preliminary judgment can be made according to detection abnormity, disease classification is judged based on the current diagnosis result, further detection suggestions are given, and finally a doctor makes further diagnosis or treatment suggestions; through the treatment suggestion module, disease causes can be judged according to the diagnosis result, and detection cost budget of a patient is combined, so that the diagnosis and treatment efficiency is improved. Giving out treatment suggestions; the detection suggestion module, the diagnosis module and the treatment suggestion module jointly act to form a medical decision-making system, non-common diseases can be found easily, the problem of cross-department missed diagnosis is solved, the medical budget planning function is achieved, and doctors and patients can provide accurate treatment suggestions easily.

The invention discloses lactobacillus plantarum capable of relieving enteritis and toxicity of polystyrene nano-plastics, and the preservation number of the lactobacillus plantarum is CGMCC (China General Microbiological Culture Collection Center) NO.31420. The lactobacillus plantarum can be used for relieving enteritis and toxicity of polystyrene nano-plastics. The strain is obtained by separating and purifying baby feces, and can grow on an MRS culture medium, and the bacterial colony is round, off-white, smooth and opaque. Experiments show that the lactobacillus plantarum can effectively adsorb PS-NPs, promote the PS-NPs to be discharged along with excrement, reduce accumulation of the PS-NPs in organs, and significantly reduce toxicity and inflammatory response of organs such as liver and kidney of mice. In addition, the strain can repair the intestinal barrier function, regulate liver metabolism and relieve enteritis symptoms. The invention further provides a probiotic preparation containing the strain, and the probiotic preparation can be prepared into granules, capsules, tablets or oral liquid and the like and is used for preventing or treating intestinal injury and inflammatory diseases caused by PS-NPs. The strain is safe and efficient, and has a wide application prospect.

The invention discloses a camel blood polypeptide and application thereof in preparation of an alpha-glucosidase inhibitor, a series of polypeptide products are separated from camel blood, and it is found that the camel blood polypeptide with the amino acid sequence being YFKI, DPPTMEL, DKPFGPDL or SEPSGTAFG has the remarkable alpha-glucosidase inhibitory activity; the compound can be applied to preparation of drugs for treating diseases caused by abnormal activity of alpha-glucosidase.

The invention relates to the technical field of bridge disease diagnosis and maintenance, in particular to a bridge disease diagnosis and maintenance measure recommendation method which comprises the following steps: constructing a bridge disease database which comprises feature data and cause data of various types of bridge diseases and maintenance measure data matched with the various types of diseases; receiving field disease information of a target bridge input by a user, wherein the field disease information comprises a disease type and a disease characteristic parameter; performing matching analysis on the field disease information and data in the bridge disease database, and diagnosing a disease cause of the target bridge based on a matching result; according to the diagnosed disease causes, one or more maintenance measures corresponding to the disease causes are called from the bridge disease database and output as recommended schemes, and a complete data link from disease detection to maintenance decision is established by constructing the standardized bridge disease database and a matching mechanism.

The invention belongs to the technical field of biology, and particularly relates to a mouse hepatitis virus antibody or an antigen binding fragment thereof as well as a preparation method and application thereof. The antibody or the antigen binding fragment thereof can specifically recognize and bind to the mouse hepatitis virus or the NSP3 protein thereof, and has good affinity with the mouse hepatitis virus or the NSP3 protein thereof; the kit can be used for preparing products for diagnosing, preventing and / or treating mouse hepatitis virus infection or diseases caused by the mouse hepatitis virus infection, detecting existence or level of mouse hepatitis virus or NSP3 protein in a sample, screening medicines for preventing and / or treating the mouse hepatitis virus infection or the diseases caused by the mouse hepatitis virus infection, and carrying out basic research and / or vaccine development.

The invention relates to the technical field of artificial intelligence medical diagnosis, and discloses a remote disease diagnosis system based on artificial intelligence driving. The system comprises five functional modules, a real-time medical data acquisition module acquires multi-modal physiological data of a patient from a remote terminal in real time, and the multi-modal physiological data comprises vital sign time sequence data, medical image data and symptom description text data; the cross-modal correlation analysis module carries out feature fusion on the data, extracts a correlation mode between modals and generates an abnormal feature data set with a weight mark; establishing a dynamic diagnosis baseline by the dynamic diagnosis baseline model, and adapting to individual physiological feature changes by updating parameters; the abnormal behavior detection module is used for comparing the real-time data with a baseline, identifying abnormal indexes and generating a marking result; the deep pathogenesis tracing module analyzes a potential disease mode and traces a pathogenesis path in combination with a patient's historical medical record. The system can optimize the remote diagnosis effect and assist clinical diagnosis and treatment.

The invention belongs to the technical field of cytotoxicity intervention, and particularly relates to application of an iNOS inhibitor in preparation of a medicine for relieving cellular injury caused by toxin combined exposure. KK-1 cells serve as a research model, it is shown for the first time that MC-LR and NaNOS combined contamination can remarkably up-regulate the expression level of iNOS protein, and it is found through tests that Nos2 gene silencing can remarkably relieve tight junction damage and cell apoptosis caused by toxin combined exposure in the KK-1 cells; it is revealed for the first time that iNOS is a core target of toxin combined exposure induced cell tight junction damage and apoptosis, and the blank of toxic mechanism research in toxin combined exposure is filled. The application provides a new direction for a detoxification strategy of environmental toxin combined exposure, provides a theoretical basis for developing an iNOS-targeted inhibitor, and also provides a new target for etiological recognition, early diagnosis and prevention of related diseases caused by environmental toxin combined exposure.

The invention relates to an anti-RSV polypeptide membrane fusion inhibitor as well as a preparation method and application thereof. The invention discloses a compound, a pharmaceutical salt or a derivative thereof, a pharmaceutical composition and a preparation product containing the compound, and application of the compound and the pharmaceutical salt or the derivative in preparation of medicines for preventing and / or treating diseases caused by RSV or other paramyxoviridae viruses. The polypeptide disclosed by the invention shows the anti-RSV activity and safety which are obviously superior to those of positive control polypeptide. Molecular interaction experiments show that the polypeptide acts on the NHR region of the RSV F protein, and the fusion of the RSV virus and a target cell is prevented by forming an inactive six-helix structure with NHR, or by destroying the RSV NHR structure and inhibiting the process of forming a six-helix bundle by NHR and CHR in the F protein in the key step of RSV infection.

The invention discloses application of tannic acid combined triazole medicines in preparation of medicines for treating diseases caused by fungi, and belongs to the technical field of antifungal. A series of drug sensitive tests show that tannic acid lower than 3 [mu] g / ml has no influence on the activity of human vaginal epithelial cells, and after the tannic acid is combined with fluconazole, the tannic acid can significantly inhibit the growth activity of drug-resistant candida (including drug-resistant candida albicans and drug-resistant candida glabrata). In view of the natural property, wide source and low toxicity of tannic acid, the invention provides a new antifungal treatment strategy, and the tannic acid has important clinical application value for treating infection (such as vaginal candidiasis) caused by drug-resistant fungi, especially under the condition that the existing antifungal drugs are poor in effect. Therefore, the tannic acid combined triazole medicine can be used for preparing the medicine for treating diseases caused by fungi.

The invention relates to a traditional Chinese medicine composition for treating haemorrhoids and a preparation method and application thereof.The traditional Chinese medicine composition is prepared from, by weight, 20-60 parts of sargentgloryvine stem, 15-45 parts of moutan bark, 20-40 parts of dandelion, 20-40 parts of rheum officinale, 20-40 parts of radix paeoniae rubra and 10-30 parts of lithospermum erythrorhizon. The traditional Chinese medicine composition has the effects of cooling blood and detoxifying, promoting blood circulation to remove blood stasis and relieving swelling and pain through combination of all the medicines, can remarkably relieve inflammation and pain of haemorrhoids through test verification, and has the potential of industrial production and popularization.

The invention belongs to the technical field of biotechnology and genetic engineering, and particularly relates to application of recombinant RASA3 in preparation of a medicine for preventing and treating viral pneumonia. The recombinant RASA3 is used for promoting autophagy degradation of a transcription factor CEBP / beta protein and reducing the expression level of the transcription factor CEBP / beta protein, so that generation of inflammatory factors such as IL-6 is reduced, and inflammatory damage caused by excessive antiviral innate immune response in the virus infection process is improved. The invention provides a novel treatment strategy for inflammatory diseases caused by RNA viruses such as influenza and respiratory syncytial virus infection.

The invention belongs to the technical field of disease prevention and treatment and aquaculture, and relates to application of acacetin in preparation of a medicine for preventing and treating white spot syndrome. The invention discloses that the acacetin has the biological activity of resisting the white spot syndrome virus for the first time, verifies that the acacetin can obviously inhibit the replication of the white spot syndrome virus in the procambarus clarkia body, and simultaneously improves the survival rate of the procambarus clarkia infected by the white spot syndrome virus. The acacetin has a good antiviral effect on the white spot syndrome virus in crustacean aquaculture, and can be applied to prevention and treatment of aquatic animal diseases caused by the white spot syndrome virus.

Disclosed in the present invention is a use of alisol-B23-acetate (AB23a) in the preparation of a drug for preventing or treating hypertrophic cardiomyopathy and diseases caused by the hypertrophic cardiomyopathy. The present invention provides for the first time a use of AB23a in the prevention or treatment of hypertrophic cardiomyopathy. According to the present invention, use of AB23a in direct in vitro treatment of cardiomyocytes derived from directed differentiation of human embryonic stem cells revealed that AB23a-based in-vitro treatment can significantly inhibit hypertrophic phenotypes of the human embryonic stem cells-cardiomyocytes; using an AB23a-containing feed to feed mice with hereditary hypertrophic cardiomyopathy caused by a gene mutation revealed that AB23a prominently relieves pathological myocardial hypertrophy of the mice and improves the cardiac function; AB23a can be used for preparing a drug for resisting hereditary hypertrophic cardiomyopathy, offering a novel way and means for treating hypertrophic cardiomyopathy; and AB23a is the main medicinal ingredient in the traditional Chinese medicinal herb-Rhizoma Alismatis, is safe to organisms, and has good clinical application prospects.

The invention provides an agricultural pest correlation analysis and diagnosis method and system based on a knowledge graph, and the method comprises the steps: firstly collecting a multi-source agricultural monitoring data set, including crop growth stage parameters, meteorological fluctuation parameters and the like, of a target region, and then processing meteorological and soil humidity parameters through an environment feature extraction model to generate a multi-dimensional environment feature set; processing disease and pest symptom image data by using a symptom feature extraction model to generate a symptom feature set, calculating dynamic correlation degree parameters of the two based on a knowledge graph topological structure, constructing a disease and pest cause probability distribution diagram, and then performing joint reasoning on crop growth stage parameters and the cause probability distribution diagram by using a pre-trained disease and pest diagnosis model to obtain a disease and pest disease diagnosis result. And finally, matching an optimal control strategy set according to the multi-level disease and insect pest diagnosis results, and inputting the optimal control strategy set into an agricultural decision-making system to trigger control equipment regulation and control operation, thereby realizing scientific and effective disease and insect pest diagnosis and control.

The invention belongs to the technical field of brain function monitoring, and discloses a three-in-one non-invasive brain function monitoring system and method, a medium, equipment and application, and the monitoring method comprises the following steps: monitoring brain oxygen saturation of a critical patient; carrying out transcranial Doppler ultrasonic measurement on intracranial blood vessel blood flow velocity and ultrasonic measurement on the inner diameter of the optic nerve sheath; monitoring a quantitative electroencephalogram of the patient; various brain function monitoring series indexes and continuous changes of the indexes along with disease evolution are obtained, the pathogenic mechanism and pathogenesis of the indexes are found in time, and primary diseases and related complications of the primary diseases are treated. According to the invention, the brain oxygen saturation can avoid too low brain oxygen or low brain oxygen for a long time and too high brain oxygen due to oxygen utilization disorder; cerebral blood flow can be monitored through a transcranial Doppler (TCD) technology to find an optimal craniocerebral perfusion pressure (CPP), and a cerebral blood flow self-adjusting function is enabled to be in an optimal state; the electroencephalogram can avoid early warning of over-sedation or abnormal discharge and the like. Through organic combination of the three, noninvasive, real-time and dynamic monitoring of critical patients is realized.

The invention discloses application of an OsMYB23 gene in improving resistance of rice to ustilaginoidea virens, and belongs to the technical field of gene engineering. The nucleotide sequence of the CDS region of the OsMYB23 gene is as shown in SEQ ID NO. 2. Researches find that the OsMYB23 gene is related to the resistance of rice to the false smut, the over-expression of the OsMYB23 gene significantly reduces the disease resistance of the rice to the false smut, the mutation of the OsMYB23 gene improves the defense capability of the rice to the false smut, and the mutation of the OsMYB23 gene does not influence the normal growth of the rice, so that the OsMYB23 gene of the rice can be used for improving the resistance of the rice to the false smut, and the rice can be used for preparing the rice for preventing and treating the false smut. And a theoretical basis is provided for prevention and control of rice ustilaginoidea virens and diseases caused by the rice

The invention relates to antiviral application of a membrane fusion inhibition polypeptide. The membrane fusion inhibition polypeptide is used for treating diseases caused by virus infection of pneumoviridae.

The invention relates to a lactobacillus rhamnosus YYSJ019 strain for relieving obesity and application of the lactobacillus rhamnosus YYSJ019 strain. The lactobacillus rhamnosus YYSJ019 strain is classified and named as lactobacillus rhamnosus, and the preservation number of the lactobacillus rhamnosus YYSJ019 strain is CGMCC (China General Microbiological Culture Collection Center) No.33472. The strain has good tolerance and high surface hydrophobicity in gastric juice, and has the potential of smoothly entering the gastrointestinal tract of a human body; the bacterial strain has excellent intestinal adhesion capability, and provides a basis for continuously playing a probiotic effect; the strain can slow down weight gain of obese mice and improve fat accumulation, liver injury and inflammation in bodies of the obese mice; the blood sugar metabolism capability and the blood fat metabolism capability can also be improved, and the potential of preventing and treating hyperglycemia or hyperlipidemia is achieved; in addition, a mouse small intestine endocrine cell line (STC-1 cell line) can be stimulated to generate the glucagon-like peptide-1, and the glucagon-like peptide-1 has the potential of improving diseases caused by insufficient secretion of the glucagon-like peptide-1; the effects of reducing uric acid in vitro and reducing uric acid in vivo are achieved, and the potential of preventing and treating hyperuricemia is achieved.

The invention discloses a method and a system for constructing an intestinal obstruction pathogenesis identification model based on multi-phase feature fusion, which are suitable for clinical diagnosis scenes with complex intestinal obstruction types and various image expressions. The method comprises the following steps: acquiring a multi-stage CT image of a patient, performing image preprocessing and structural partitioning, extracting phase-to-phase structural consistency, identifying a pseudo-difference area and a non-focus interference area, and suppressing the characteristics of the pseudo-difference area and the non-focus interference area; and meanwhile, in combination with disease cause region difference enhancement, structure expectation template comparison and dynamic tolerance analysis, intelligent discrimination of multiple disease causes such as adhesion type, tumor type, telescoping type and the like is realized. The system has the advantages of being high in model interpretability, sensitive to negative signs and high in artifact interference resistance, and the accuracy and clinical applicability of automatic identification of ileus causes are improved.

The invention discloses enterobacter mori capable of resisting fish aeromonas and application of the enterobacter mori, the bacterial strain is classified and named as enterobacter mori SCH0241, the enterobacter mori SCH0241 is preserved in the China Center for Type Culture Collection on October 17, 2024, and the preservation number is CCTCC NO: M 20242236. The enterobacter mori SCH0241 disclosed by the invention is derived from the intestinal tract of high-stress-resistance healthy hybrid crucian carassius auratus No. 2, has good contact dependence antibacterial activity on aeromonas veronii, and can improve the capability of resisting aeromonas veronii infection of zebra fish. Through construction of an insertion mutation library and phenotype screening, it is found that a gene cluster of SCH0241, which exerts contact inhibition toxicity, is T6SS-2. The enterobacter mori SCH0241 disclosed by the invention provides a new powerful tool for biological prevention and treatment of fish diseases caused by aeromonas veronii.

The invention discloses a VdNOB1 gene as well as an anti-pathogenic bacterium target gene segment, an interference vector and disease-resistant application thereof. According to the invention, the VdNOB1 gene is subjected to knockout mutation, so that the infection pathogenicity of verticillium dahliae to host plants can be obviously reduced. The invention further provides a verticillium dahliae VdNOB1 gene anti-pathogenic bacterium target gene segment, the nucleotide sequence of the verticillium dahliae VdNOB1 gene anti-pathogenic bacterium target gene segment is shown as SEQ ID No.4, and the pathogenicity of verticillium dahliae to host plants can be remarkably reduced after plants are transformed by an RNA interference vector constructed by the verticillium dahliae VdNOB1 gene anti-pathogenic bacterium target gene segment. The invention further provides an RNA (Ribonucleic Acid) interference vector containing the VdNOB1 gene or an anti-pathogenic bacterium target gene fragment thereof. The verticillium dahliae VdNOB1 gene or the anti-pathogenic-bacterium target gene segment and the RNA interference vector thereof have application prospects in the aspects of improving the resistance of crops to diseases caused by verticillium dahliae, cultivating new varieties of verticillium dahliae-resistant plants and the like.

The invention relates to the field of artificial intelligence medical treatment, in particular to an AI-driven clinical decision tree dynamic evolution training system, which comprises a multi-source medical data acquisition module which is responsible for acquiring medical images, medical examinations, biomarkers, pathological images and clinical information data, a clinical decision path data pool receives and structurally processes the data, and an AI-driven clinical decision tree dynamic evolution training module is established; a training data set is formed, a topological mapping space construction module constructs a high-dimensional topological space based on the data set to represent a clinical decision path, a multi-order progressive evaluation module performs multi-dimensional performance evaluation on the decision path mapped to the high-dimensional space, and a decision path training and analysis module optimizes the decision path according to an evaluation result. The optimized model is stored in a decision path library and forms a training feedback cycle with a clinical decision path data pool, and high-dimensional expression of a complex medical relationship is realized through a topological mapping space construction module, so that the diagnosis capability of the model on multi-cause and multi-symptom diseases is remarkably improved.

The present invention has an object of providing a composition that is effective for the treatment of a prototheca disease. According to the present invention, a composition containing ravuconazole as an active ingredient, which is administered to an animal suffering from a prototheca disease caused by Prototheca wickerhamii or Prototheca zopfii, is provided.

The invention discloses an engineered exosome for promoting hair regeneration and a preparation method and application thereof, Wnt10b gene is inserted into a plasmid vector to construct a target plasmid, the target plasmid and a lentivirus packaging plasmid are co-transfected to packaging cells to generate lentivirus particles, and then target stem cells are infected. Screening to obtain a cell strain capable of stably expressing a target gene, culturing the stably transfected strain, and collecting the engineered exosome generated by the stably transfected strain. The exosomes are rich in Wnt10b protein and can promote proliferation and differentiation of hair follicle stem cells on a molecular level, so that hair follicle tissues in a resting period are activated and enter a growing period again, and hair regeneration is realized. Meanwhile, the exosome is high in safety, and adverse reactions caused by traditional chemical synthesis drugs are avoided. The exosome can be applied to the preparation of hair regeneration products, and the accurate symptomatic treatment capability of the exosome provides a hair growth method aiming at pathogenesis for alopecia patients, and provides a new hope for patients who seek safe and effective hair growth solutions.

The invention discloses an establishment method and application of a damp-heat intestine accumulation type ulcerative colitis animal model, and belongs to the field of animal models.The establishment method comprises the steps that S1, high-fat feed treatment is conducted, specifically, experimental animals freely eat high-fat feed for 6-10 weeks from the first day; s2, DSS treatment: feeding 1.5% (w / v) DSS solution to the experimental animal for 2 weeks; and S3, observing the damp-heat syndrome type and ulcerative colitis related indications of the experimental animals, and selecting the experimental animals meeting the scoring standard, thereby establishing the ulcerative colitis mouse model. Aiming at the situation that most patients induce ulcerative colitis due to excess energy due to the change of dietary structures and lifestyles at present, the invention constructs and evaluates the damp-heat accumulation type ulcerative colitis mouse model by inducing internal dampness by a direct pathogenesis (high fat diet), which is closer to the actual situation of clinical patients. Therefore, a model and reference are provided for research and treatment of pathology of the damp-heat accumulation type ulcerative colitis and pharmacological mechanisms of traditional Chinese medicines.