264results about How to "Easy to aim" patented technology

A system and method for building and / or manipulating a centralized medical image quantitative information database aid in diagnosing diseases, identifying prevalence of diseases, and analyzing market penetration data and efficacy of different drugs. In one embodiment, the diseases are bone-related, such as osteoporosis and osteoarthritis. Subjects' medical images, personal and treatment information are obtained at information collection terminals, for example, at medical and / or dental facilities, and are transferred to a central database, either directly or through a system server. Quantitative information is derived from the medical images, and stored in a central database, associated with subjects' personal and treatment information. Authorized users, such as medical officials and / or pharmaceutical companies, can access the database, either directly or through the central server, to diagnose diseases and perform statistical analysis on the stored data. Decisions can be made regarding marketing of drugs for treating the diseases in question, based on analysis of efficacy, market penetration, and performance of competitive drugs.

Oligonucleotides for genotyping the thymidylate synthase gene are provided. The number of tandem repeats in the promoter region of the thymidylate synthase gene can be identified based on the hybridization of an oligonucleotide of the invention to the genomic DNA of a subject. Therefore, the genotype of the thymidylate synthase gene can be identified based on the number of tandem repeats. The genotype relates to the responsiveness of a subject towards an antitumor agent.

Methods and apparatus for the remote coagulation of blood using high-intensity focused ultrasound (HIFU) are provided. A remote hemostasis method comprises identifying a site of internal bleeding and focusing therapeutic ultrasound energy on the site, the energy being focused through an intervening tissue. An apparatus for producing remote hemostasis comprises a focused therapeutic ultrasound radiating surface and a sensor for identifying a site of internal bleeding, with a registration means coupled to the radiating surface and the sensor to bring a focal target and the bleeding site into alignment. The sensor generally comprises a Doppler imaging display. Hemostasis enhancing agents may be introduced to the site for actuation by the ultrasound energy.

The invention relates to a system for monitoring a cumulative physiological state and for predicting a target state under physical exercise, which system includes means for measuring a variable depicting the intensity of the exercise and for registering it relative to time, the control unit consisting of a user-interface device, which includes an input device and output device. Software means calculate the current value of the said cumulative physiological variable while second software means calculate the value of a selected output variable, which output variable is one of the following three variables: target state, future intensity, or duration of future exercise, the two other variables being given as initial variables.

User exposure to media items is detected and measured. A mobile client device carried by a user digitally samples the audio environment of the user on a regular basis. These samples are transformed into a stream of data signatures and compared with reference media items to detect user exposure to the reference items. Purchase behavior following exposure to selected media content items can be detected and tracked as well, so as to gauge effectiveness of media items such as advertisements.

The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides or nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are T cells and NKT cells activated by the above compositions that can be administered for adoptive immunotherapy.

A system and method is provided for illuminating a subject using a light pipe that transmits light from a source, such as an LED ring illuminator to an outlet that directs the light appropriately as either bright field illumination, dark field illumination or both. The light pipe can include concentric cylinders, typically with a bright field illuminator nested within a dark field illuminator. The tip of the dark field illuminator may be angled so as to internally reflect light inwardly toward the central optical axis of a camera at a low angle. The tip can be located near the focal plane of the camera for the desired field of view. The field of view of the camera sensor can be modified to reject data outside of a illumination field of a particular shape. This illumination field can be created by shaping the light pipe in a predetermined form that projects the modified illumination field. Likewise, a set of aiming illuminators (in, for example, a noticeable color) can be provided around the perimeter of the light pipe to delineate outer boundaries of the illumination field or area of interest. These approaches facilitate better aiming of the sensor into the desired area of interest so that it is illuminated and / or acquired most-fully.

An improved recessed lighting fixture allowing illumination from a lighting unit placed within a cavity of a planar surface, such as a ceiling or wall. The invention facilitates the ability to properly aim illumination because the user can aim the fixture while it is in place and illuminated. The invention is additionally designed to allow the substitution of lamps / light bulbs without requiring re-aiming of the fixture and to be used without modification with ceiling materials of varying thickness. The invention also includes an azimuthal adjustment mechanism wherein the lamp is mounted on a gimbal having a rack and pinion coupling to rotate the gimbal under control of a screw accessible from the exterior of the fixture and a horizontal aiming system.

Embodiments of the present invention permit a user to receive content that is directly targeted to that particular user's interests, including a method for targeting content that is arranged on a page that is displayable by a computing device, including the steps of displaying a list of categories of available advertising content, wherein the available advertising content is stored in a database, receiving a selection of at least one of the categories of the advertising content from a user, selecting advertising content from the database that corresponds to the selection of categories received from the user, and transmitting a page including the selected advertising content to a computing device for display on the computing device. In addition, embodiments of the present invention allow the tracking of content from when it is initially shared, to when revenue is generated based on an action of a user on the shared content portion.

This invention provides methods for the stable introduction of heterologous coding sequences into the genome of a bird and expressing the coding sequences to produce desired proteins or to alter the phenotype of the bird. The present invention provides preferred methods for introducing a transgene into the cytoplasm of avian embryonic cells by cytoplasmic microinjection. The embryo then develops into a transgenic adult capable of expressing a heterologous protein and / or capable of generating a line of transgenic birds through breeding. Synthetic vectors and gene promoters useful in the methods are also provided by the present invention, as are transgenic birds that express heterologous protein and avian eggs containing heterologous protein.

An electrical discharge weapon configured as a lightweight, slim profile gun-shaped weapon which is less than one inch thick along the cartridge receiving chamber so that it can be readily placed in a police officer's uniform pocket or in a slim-line holster for easy deployment. All of the major internal components, including battery and transformer, are positioned above or behind the trigger aperture so that even with the dart cartridge in the chamber, the weapon's center of gravity is through the hand so that it is balanced and easily aimed at the target. The invention employs a specially configured chamber to receive a unique cartridge with widely separated darts. As a result, the electrodes may be also widely separated so that current will not jump the electrode gap even when the impacted darts leave a substantial gap to a suspect's skin. Thus, the present invention is more likely to be effective against suspect's wearing thick outerwear. The spent cartridge may be expelled by a spring-activated release for quick ejection and rapid reload. A bottom rail permits connection of another non-lethal device such as a mace canister for use as a secondary weapon or the attachment of tactical lighting or laser aiming devices. A push-on / push-off trigger switch is combined with a mechanical safety device to assure weapon effectiveness and safety for the police officer. Quick disconnect battery clip allows for rapid battery replacement.

An apparatus for delivering HIFU energy may include a probe with a plurality of leaves that provide a bowl-shaped HIFU therapy transducer. In once case, pins may slide within grooves in the leaves to deploy the leaves. In another case, spines may be configured to slide in a channel defined in each leaf. In other cases, a spring or a shape memory alloy may be used to deploy the leaves. In another implementation, a probe may be fitted with a flexible material that couples the HIFU therapy transducer to the probe and allows the transducer to be drawn to the side of the probe for insertion. In another implementation, a probe may have one or more inflatable bladders that form the HIFU therapy transducer. In yet another implementation, a probe may have an imaging component and a HIFU therapy transducer disposed thereon that rotate, as a unit, about a hinge.

A crossbow having a bowstring cocking winch apparatus, a cocking winch apparatus usable with a crossbow, and a method of operating the apparatus are described. The cocking winch apparatus includes a projecting alignment member having a non-round cross-sectional shape, where the alignment member is removably securable to a butt portion of a crossbow stock by inserting the alignment member into a correspondingly-shaped hole formed in the stock. The cocking winch apparatus provides a straight and balanced draw to the crossbow bowstring, enabling a user to easily cock the bowstring by rotating a handle to draw the bowstring back, and to place it in cocked position in the crossbow trigger mechanism.

The invention relates to a smoke exhaust, fire extinguishment and dismantling robot which comprises a vehicle body, a chassis walking device installed on the lower part of the vehicle body, a power device, a working device, a waterway system, a hydraulic system and an electric system, wherein two exhaust blowers are arranged on the upper part of the vehicle body; the side surfaces of the two exhaust blowers are respectively provided with a water cannon and a foam cannon; and a dismantling device is installed at the front end of the vehicle body and comprises an arm frame and a dismantling tool which is connected with the arm frame through a quick change coupler. The smoke exhaust, fire extinguishment and dismantling robot is concise in structure and strong in practicability, can be used for replacing a fire fighter to enter into a fire scene with important safety hidden dangers to carry out short distance fire fighting operation, can carry out water and foam remote control spraying and video transmission on the fire scene, has a self-protection sprinkling device and has the functions of large power smoke exhaust, water mist spraying and strong walking and climbing as well as the functions of dismantling, object grabbing and bucket to an obstacle, so that the working efficiency is greatly improved, the safety is high, and the smoke exhaust, fire extinguishment and dismantling robot is convenient to popularize and apply.

The present invention provides pharmacological compounds including an effector moiety conjugated to an binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

A mounting bracket assembly has a stationary bracket to be mounted on a pole or other surface, and an adjustable bracket to be attached to the object to be mounted. The adjustable bracket is then positioned on the stationary bracket to mount the object on the surface or pole. The adjustable bracket is first mounted on the stationary bracket in a preliminary mounting position using integrated hooks and latches, and then can be easily adjusted to a permanent mounting position and secured with screws.

A method and apparatus utilizing a high-precision GNSS receiver, an EDM, and an optical camera in combination for making accurate measurements of multiple remote points. The accurate measurement of a plurality of remote points is facilitated by integrating a high-precision GNSS receiver, an EDM and an optical camera such that their combined physical location and orientation can be measured and known, and allowing for a single calibration thereof. The integration of the high-precision GNSS receiver, an EDM, and an optical camera may take various forms such as a single, integrated device, or individual devices assembled together on a surveying pole, for example. The integrated device may also include one or more sensors such as an inclination sensor and an inertial measurement unit.

A robot arm end effector mechanism for a mobile, remotely controlled robot includes an arm housing; an end effector bearing sleeve rotatable relative to the arm housing; a roll motor unit, fixed to the arm housing and having a roll drive axis, for rotating said bearing sleeve; and an end effector motor unit having an end effector drive axis and being fixed to and rotatable with the bearing sleeve for operating the end effector.

The invention relates to a system for monitoring a cumulative physiological state and for predicting a target state under physical exercise, which system includes means for measuring a variable depicting the intensity of the exercise and for registering it relative to time, the control unit consisting of a user-interface device, which includes an input device and output device. Software means calculate the current value of the said cumulative physiological variable while second software means calculate the value of a selected output variable, which output variable is one of the following three variables: target state, future intensity, or duration of future exercise, the two other variables being given as initial variables.

A connector device for kill- and choke lines between a riser and a floating drilling platform includes a slip joint on top of the riser including an outer barrel, a kill- and choke manifold arranged on the platform and provided with flexible kill- and choke hoses to the slip joint's outer barrel, and wherein the slip joint's outer barrel is provided with a horizontally directed kill- and choke-manifold.

Current treatment options for Overactive Bladder and Urinary Incontinence include exercise and behavioral modifications, pharmacological therapies, surgical intervention, and neuromodulation. Although each of these treatments is used in the treatment of individuals with these conditions, each has severe limitations. Building on the limitations of existing therapies, and with the distillation of lessons learned from the field of pulsed electric stimulation, the present invention employs Low Frequency Induction Therapy for the delivery of an effective, cost efficient, noninvasive alternative to available treatment options. The device of the present application allows for consistent, user-friendly modulation of the pudendal nerve and the sacral plexus, via pulsed electromagnetic stimulation of the posterior tibial nerve, on an outpatient basis. The device has two primary components: a programmable Logic Controller (LC), which generates the required current, and a Conductive Wrap (CW), through which the current is channeled in generating the pulsed electromagnetic fields.

The present invention is generally directed to assisting users to position a pointer on a target. Embodiments of the present invention provide a system, method, and computer-readable medium that guide a pointer toward a target. After the pointer is located on a target, pointer movement continues to be adjusted so that the user may easily keep the pointer located on the target.

A system and method is provided for illuminating a subject using a light pipe that transmits light from a source, such as an LED ring illuminator to an outlet that directs the light appropriately as either bright field illumination, dark field illumination or both. The light pipe can include concentric cylinders, typically with a bright field illuminator nested within a dark field illuminator. The tip of the dark field illuminator may be angled so as to internally reflect light inwardly toward the central optical axis of a camera at a low angle. The tip can be located near the focal plane of the camera for the desired field of view. The field of view of the camera sensor can be modified to reject data outside of a illumination field of a particular shape. This illumination field can be created by shaping the light pipe in a predetermined form that projects the modified illumination field. Likewise, a set of aiming illuminators (in, for example, a noticeable color) can be provided around the perimeter of the light pipe to delineate outer boundaries of the illumination field or area of interest. These approaches facilitate better aiming of the sensor into the desired area of interest so that it is illuminated and / or acquired most-fully.

A projectile launcher has a magazine of launching chambers for holding a plurality of projectiles at the launcher's front end. The projectiles are launchable by the delivery of a blast of compressed air through each chamber's respective air inlet. The air inlets are uniformly spaced in a substantially cylindrical array about the magazine. A piston with a handle is adjacent to the rear end of the launcher body. The piston has a longitudinal axis coaxial with the cylindrical array, and the piston is movable in back-stroke and fore-stroke motions along that axis for inhaling air into the launcher during the back-stroke and exhaling air from the launcher though one of said air inlets in blasts of compressed air during the fore-stroke. A rotatable diverter directs the blasts to one of the air inlets individually and sequentially upon successive backstroke and fore-stroke cycles of the piston.

A method and apparatus are provided for determining and tracking location of a metallic object in a living body, and then directing a second modality such as ultrasound waves to the determined location. The metal detector may be a radar detector adapted to operate on a living body. The adaption may include disposing a transfer material having electromagnetic properties similar to the body between the radar detector and the living body, ECG gating the radar detector, and / or employing an optimal estimator with a model of expected stent movement in a living body. Applications include determination of extent of in-stent restenosis, performing therapeutic thrombolysis, or determining operational features of a metallic implant.