368results about How to "Small dose" patented technology

The present invention relates to a method capable of using natural and artificial synthetic isosulfocyanate compound or its derivative to prevent and cure prostatic diseases and skin carcinoma. The internal tests show that various isosulfocyanate compounds or their derivatives can induce prostatic cell II phase drug metabolic detoxication enzyme-glutathione transferase so as to can inhibit the hyperplasia of prostate and inflammation, and can prevent and cure prostatic carcinoma and skin carcinoma.

The invention discloses a water soluble corrosion inhibitor, the preparation method and the application of the corrosion inhibitor, solving the defect of narrow application range of the corrosion inhibitor pH in the prior art; the water soluble corrosion inhibitor is composed of 20-70 weight proportion of imidazolines derivates, 1-10 weight proportion of pyridine derivates, 1-20 weight proportion of corrosion inhibition auxiliary agent and 10-50 weight proportion of solvent, based on the total weight of the corrosion inhibitor as the reference. The water soluble corrosion inhibitor in the invention has corrosion inhibition effect on the metal material in the medium with wide PH variation range (pH equals to 1-10) and good metal surface film formation property.

The invention belongs to the field of application of near-infrared laser, nuclear irradiation, electron and image rebuild in systematic biology and medicine. It is characterized in that high-specificity nuclear species and fluorescent probe are implanted in live animal to realize double mark of muscle deep layer or internal organ tumor cell. The emission signal of nuclear species is checked by sensitive electron-multiplier phototube in array copulation position of scintillation crystal; feeble fluorescent signal generated by visible light or infrared agitation is checked by high quantum yield CCD camera. The two checking systems are orthogonally arranged in the same surface, the live nuclear species and fluorescent signal can be checked simultaneously through rotary image cavity, and double module three dimensional tomography image of small animal can be rebuilt with software algorism. The invention is characterized by multi-image forming modules, abundant information and simple operation.

The invention relates to an inhalation spray of antivirus medicines. The inhalation spray comprises the following components in percentage by mass of 0%-30% of antivirus activity agents, 0%-30% of auxiliary agents, 0%-30% of taste masking agents and the balance solvents, wherein the content of the antivirus activity agents and the content of the auxiliary agents are not 0% at the same time. Compared with the prior art, the inhalation spray disclosed by the application has the purpose that during outbreak period of epidemic corona viruses and other viruses, people do not need to occupy medicalresources in short supply and only need to inhale the antivirus medicines into respiratory tracts, medicine administration is accurately targeted, and the objective of preventing virus infection and propagation can be achieved; in addition, through united medication of the antivirus activity agents and the auxiliary agents, besides, various medicines are inhaled into the respiratory tract of a patient, synergistic treatment effects are generated, the viruses are eliminated, and serious respiratory tract and infection and serious pulmonary infection caused by the viruses can be treated; and chloroquine type antivirus medicines and macrocyclic antibiotics are inhaled through spraying for united medication, and the dosage of the medicines can be notably reduced, so that side effects of prolonged QT intervals, Tdp and sudden cardiac death caused by the medicines can be reduced.

A technical process for manufacturing a monocrystal lithium niobate thin film or a monocrystal lithium tantalate thin-film material. After bonding of wafers, reduction of crystal lattice intensity of a damage layer caused by ion implantation and differences of thermal expansion coefficients between a silicon dioxide layer and a lithium niobate (lithium tantalate) crystal are utilized to select an appropriate heat treatment process and form stress in wafer set, so as to strip the film. The process can substantially reduce ion implantation dosage, thereby reducing production cost and increasing film quality.

The present invention relates to an earthworm acid region medicine for curing cough and asthma diseases and its preparation method. Said earthworm acid region medicine contains fatty acid, amino acid and purine compound, and can be used for curing the diseases of asthma and chronic bronchitis, etc. Its preparation method includes the following steps: using strong base anion-exchange resin to adsorb aqueous extract of earthworm, then using dilute hydrochloric acid or alcohol-containing dilute hydrochloric acid to make elution.

A solid medicinal preparation to which improved solubility has been imparted, while maintaining preparation stability, by taking a formulation contrivance on a sparingly water-soluble chemical substance as an active ingredient for the medicine. The solid preparation comprises a sparingly water-soluble chemical substance as an active ingredient, a water-soluble polymer, and an inorganic porous substance and has improved water solubility. It is characterized in that (1) the sparingly water-soluble chemical substance forms a solid dispersion together with the water-soluble polymer, (2) the water-soluble polymer as a component of the solid dispersion is in the form of fine pieces, and (3) the fine pieces of the water-soluble polymer are held on the surface of the inorganic porous substance in the state of being adsorbed on and/or adherent to the surface. The solid preparation can be produced by dissolving a sparingly water-soluble chemical substance as an active ingredient and a water-soluble polymer in an organic solvent, mixing the resultant solution with an inorganic porous substance with stirring, subsequently granulating the mixture, and then drying the granules.

The invention discloses chitosan nanoparticle and a preparation method and application thereof. Chitosan and sodium tripolyphosphate are used to react and obtain the nanoparticle through rotary evaporation, concentration and spray drying. The invention adopts the simple and feasible method for the chitosan nanocrystallization, thus significantly increasing the activity of chitosan, solving the problem that chitosan is difficult to absorb and dissolve, greatly reducing the side effect and fundamentally resolving the current technical problems and technical bottleneck for losing weight and reducing blood fat of chitosan. The method of the invention is simple and feasible, has low cost and is easy to promote.

A therapy planning system and method generate an optimal treatment plan accounting for changes in anatomy. Therapy is delivered to the subject according to a first auto-planned optimal treatment plan based on a first image of a subject. A second image of the subject is received after a period of time. The second image is registered with the first image to generate a deformation map accounting for physiological changes. The second image is segmented into regions of interest using the deformation map. A mapped delivered dose is computed for each region of interest using the dose delivery goals and the deformation map. The first treatment plan is merged with the segmented regions of the second image and the mapped delivered dose during optimization.

The invention discloses a method for disinfecting filtered water from a water plant with cooperation between medium-pressure ultraviolet catalyzing peroxymonosulfate and chloramines. The method includes following steps: adding peroxymonosulfate to outlet water from a water plant filtering tank to obtain a mixed solution with a concentration being 0.2-0.4 mmol/L through a tubular mixer; performing disinfection to the mixed solution in a medium-pressure ultraviolet disinfecting reactor, wherein an addition dosage of the medium-pressure ultraviolet is 10-20 mj/cm<2> and a disinfection time in the reactor is 5-10 min; and adding 0.3-0.4 mg/L chloramines to an end of the ultraviolet disinfecting reactor to complete the disinfection with cooperation between medium-pressure ultraviolet catalyzing peroxymonosulfate and chloramines. By means of the method, a cooperative effect of medium-pressure ultraviolet, peroxymonosulfate and chloramines fully works so that bacteria and microorganisms can be controlled in high efficiency and a reagent addition dosage and disinfection by-product can be reduced. Sustainability of disinfection and sterilization of water in a following water supply network can be ensured and drinking water safety can be ensured.

A capsule for treating rheumatic or rheumatoid arthritis, osteoarthritis, hyperosteogeny, periomethritis, lumbar muscle strain, etc. is prepared from 4 raw materials including Chinese trumpetcreeper flower 3000 g, piroxicam 10g, VB1 30 g and marasmius androsaceus 100g.

The invention discloses a dispersing agent for water non-soluble medicaments, which comprises, (1) 0.5-50 weight parts of active medicaments containing water non-soluble substance with a dissolvability of 0.001-10000mg/L of water at 25 deg C, (2) 0.5-1000 weight parts surface active agent or solubilizing agent with hydrophilyty and lipophilyty balance (HLB) >10.

The invention discloses a soluble microneedle loaded with a photosensitizer. The microneedle comprises an integrally formed base, a soluble polymer needle body positioned on the base and a needle tiploaded with the photosensitizer, the invention discloses a preparation method of a photosensitizer-loaded soluble microneedle array. The preparation method comprises the following steps: 1) preparinga polydimethylsiloxane (PDMS) mold plate; 2) carrying out laser etching on a polydimethylsiloxane (PDMS) micro-needle female die; 3) preparing a mixed solution containing a photosensitizer and a soluble polymer; (4) treating the female die obtained in the step (2) with oxygen plasma, coating the surface of the female die with the mixed solution obtained in the step (3), enabling the medicine to enter the tip end of the die in a vacuum environment, and recycling the redundant medicine; adding a soluble polymer solution to the mold, and filling the mold with the soluble polymer in vacuum; afterstanding, drying is performed, and then the polydimethylsiloxane (PDMS) microneedle array female mold is peeled off. According to the invention, the technical problem of unreasonable administration mode in photodynamic therapy can be solved, and the preparation problem of the photosensitizer-loaded soluble microneedle array is also solved.

The invention discloses novel insecticide for repelling and killing bugs, which takes chlorine fluorine ethofenprox as the active ingredient. Compared with phenothrin, dectrorotation empenthrin, and prallethrin with the same dosage respectively, the pesticide effect is over 15 times, while the cost is under 1/3; the pesticide effect of the insecticide is basically equal to that of dimefluthrin, however, the selling price of the chlorine fluorine ethofenprox is about 1/3 of that of the dimefluthrin. Compared with the prior art, the novel insecticide for repelling and killing bugs has the advantages of high pesticide effect of the active ingredient, smaller dosage and lower unit price, thus having good performance price ratio.

A method of using the synergy of multiple depressants to improve the depression of iron sulphide without compromising the recovery of the valuable sulphide minerals in the flotation of non-ferrous metal sulphides, while reducing or eliminating the use of environmentally problematic chemicals such as polyamines. The method has significant economic and environmental benefits. The multiple depressants comprise at least one organic polymer, at least one sulphur-containing compound and/or at least one nitrogen-containing organic compound.

The invention relates to the field of film-spreading oil solution, in particular to nimbin film-spreading oil solution which is prepared by mixing nimbin and nim oil in certain proportion and adding an auxiliary material into the mixture. The nimbin film-spreading oil solution is novel, efficient and pollution-free, is safe to human, livestock and fowls, and is difficult for pests to generate drug resistance. The nimbin film-spreading oil solution has the advantages of wide sources of raw materials, high utilization ratio, simple process and low production cost, and is a novel biological pesticide preparation.

The invention discloses a construction method of a crack-resisting cement stabilized crushed stone base course. The problems that at present, contraction fissures of a traditional cement stabilized crushed stone are many, the surface is prone to loosening after freeze-thaw, the defects of the construction mode exist in the construction side, and therefore large-area cracks and freeze-thaw are generated in the subsequent process of the road surface are solved. According to the key points of the technical scheme, the construction method comprises the following steps that (a), the crack-resisting cement stabilized crushed stone base course comprises a collected material, 3%-5% of cement and water, the curve of the screen hole size of the collected material and the passing percentage is in an S shape; (b), a mixture is mixed; (c), the mixture is conveyed; (d), the mixture is paved, specifically, square timber cushion blocks are put under a paver screed plate in advance, and mixture paving adopts two pavers to synchronously operate in an echelon formation mode; (e), the mixture is grinded; and (f), curing is conducted, specifically, a curing film or geotechnical cloth is covered to conduct hydrating curing, so that the surface of the cement stabilized course keeps a moist state all the time, and the cement stabilized crushed stone base course with the crack-resisting property being obviously improved is obtained.

The invention relates to the technical field of a pharmaceutical preparation for livestock and specifically discloses an enrofloxacin injection for the livestock and a preparation method thereof. The raw material of the injection is composed of enrofloxacin, artesunate, trimethoprim, flunixin meglumine, L-arginine, antioxidant, chelant, compound organic solvent and water for injection. The enrofloxacin injection for the livestock can effectively enhance the antibacterial effect of the drug, has an excellent anti-inflammatory effect and is mainly used for treating serious mixed infection caused by sensitive bacteria and mycoplasma of the livestock; the generation of drug resistance is effectively reduced; and the toxic and side effects are reduced. The preparation method for the enrofloxacin injection for the livestock provided by the invention is simple, low-cost, high in stability, convenient in use, and suitable for industrial production.

The invention provides an application of a metal derivative containing chlorophyll and hydrolyzate thereof as a plant growth regulator. The metal derivative containing chlorophyll and hydrolyzate thereof is selected from chlorophyll metal chelate, a chlorophyllin metal chelate and a monomeric metal chelate obtained by separating a chlorophyllin mixture. The chlorophyll is a green pigment extracted from a natural plant raw material and provided with a phaeophytin mother ring structure. The chlorophyllin is a mixture of multiple dihydroporphin components obtained by hydrolyzing the chlorophyll.The monomeric chlorophyllin component is selected from dihydroporphin-e4, dihydroporphin-e6 or phaeophorbide a monomethyl ester. Metal ions comprise bivalent or trivalent transition metal manganese, iron, copper or zinc ions in an oxidation state. The plant growth regulator provided by the invention has the advantages of safety, non-toxicity, low residue, strong activity, good effect, stable product property, controllable and reliable quality and easiness in promotion and application; the chlorophyll content of the plant can be increased, the root growth is promoted, the germination ratio is increased, the stress resistance is enhanced and the yield is also increased.

The present invention provides a compound biological pesticide containing nimbin. Said invention adopts zodium lauryl sulfate, polyoxyethylated alkylphenol, ammonium styrene polyoxyethylene ether sulfate and sodium alkene ethyl sulfate as emulsifying agent. The composition of said compound biological pesticide contains (by mass%) nimbin 0.2-5, biological pesticide 0.5-8, emulsifying agent 5-20 cosolvent 5-15, antifreezing agent 0.5-2, stabilizing agent 3-5, synergistic agent 0.2-1.5, pH value regulating agent 0.1-0.5 and water 45-70. It is a transparent liquid microemulsion agent, can be used for controlling various injurious insects.

The invention discloses a method for remedying polycyclic aromatic hydrocarbon contaminated soil. The method has the advantages that the polycyclic aromatic hydrocarbon contaminated soil can be remedied by the aid of ferrous ions and sodium persulfate systems, and the ferrous ions are added into the polycyclic aromatic hydrocarbon contaminated soil in batches; ferrous ion adding modes are changed,inhibiting reaction between excessive ferrous ions and sulfate free radicals can be prevented by low-dose batch adding modes, competing reaction between SO4.-, organic matters and inorganic anions can be prevented, accordingly, the removal rate of active sodium persulfate for removing PAHs (polycyclic aromatic hydrocarbons) in soil by means of oxidation can be increased, the addition dose of theferrous ions can be reduced, a low-consumption, efficient and environment-friendly treatment technology can be provided, and the method has important significance in PAHs contaminated soil treatment and remediation.

The invention discloses a novel application of albiflorin in preparing medicines for preventing and treating the Parkinson's disease. Tests prove that albiflorin has a distinct antiparkinsonian effect, quick action and low toxic and adverse effects. Albiflorin as a medicine for treating the Parkinson's disease, is safe, efficient and stable, has a simple preparation process, is suitable for industrial production, and is easy for generalization. The invention provides a new source of medicines for preventing and treating the Parkinson's disease.

The invention discloses a seed treatment agent used for preventing fungus. The seed treatment agent is characterized in containing natamycin. The seed treatment agent is prepared from natamycin, an adhesive, an anti-oxidant, a chelating agent, or water; or natamycin, other antifungal ingredients, the adhesive, the anti-oxidant, the chelating agent, and water. Seed mildew and fungal diseases can be prevented effectively via treating of seeds with the seed treatment agent, bud ratio and bud growing conditions can be improved further, and crop yield is increased. The seed treatment agent is high in efficiency, wide in pH application range, high in specificity and security, and long in antibacterial action time.

The invention belongs to the filed of medicine and discloses a pharmaceutical composition using fimasartan and rosuvastatin or medicinal salt thereof as active components, wherein a mass ratio of rosuvastatin or medicinal salt thereof to fimasartan is 1:0.25-250 and preferably 1:10-100. The pharmaceutical composition containing rosuvastatin medicinal salt thereof and fimasartan has obvious synergism on treating hypertension and complications thereof, low treatment cost, little side-effect and good clinic application prospect.

Novel analogs and prodrugs of the loop diuretic bumetanide are described. Pharmaceutical compositions containing bumetanide analogs and prodrugs are also described. These analogs and prodrugs are particularly useful for the treatment and/or prophylaxis of conditions that involve the NKCC cotransporter family (NKCC1 and NKCC2), or the KCC cotransporter family (KCC1, KCC2, KCC3, KCC4), or GABAa receptors. Such conditions include, but are not limited to anxiety disorders, epilepsy, migraine, non-epileptic seizures, sleep disorders, obesity, eating disorders, autism, depression, edema, glaucoma, stroke, ischemia, neuropathic pain, addictive disorders, schizophrenia, psychosis, and tinnitus.

The invention discloses a polycarboxylate-based ceramic water reducer and a preparation method as well as an application thereof. The water reducer comprises monomers, distilled water, an inorganic chain transfer agent and an initiator; the monomers account for 29-45 percent of the total mass of the monomer and the distilled water; the monomers comprise acrylic acid and crotonic acid; acrylic acid accounts for 66-89 percent of the total mass of the monomers, and crotonic acid accounts for 10-40 percent of the total mass of the monomers. The polycarboxylate-based water reducer based on crotonic acid has the advantages of low mixing amount, high water reducing rate, simplicity in preparation and operation and no need of compounding with inorganic salts, and meet the requirements of ceramic production enterprises; the requirements on equipment during the production of the polycarboxylate-based ceramic water reducer are simple, post treatment is unnecessary, the energy consumption is small, and no environmental pollution is generated; the dose of pottery clay is small during application, the water reducing effect is good, the fluidity of ceramic slurry can be remarkably improved, and the viscosity of ceramic slurry is reduced; no settlement phenomenon of ceramic slurry appears within the adding dose range.

The invention relates to an N-type lateral insulated gate bipolar device capable of reducing hot carrier effect. The N-type lateral insulated gate bipolar device capable of reducing the hot carrier effect comprises a P-type substrate; buried oxide is arranged on the P-type substrate, and is provided with a P-type epitaxial layer; the P-type epitaxial layer is provided with an N-type well and a P-well area, the N-type well is provided with an N-type buffering well which is provided with a P-type positive area, and the P-well area is provided with an N-type negative area and a P-type body contact area; and a field oxide layer, a metal layer, a gate oxide layer, a polysilicon gate and an oxide layer are arranged on the upper surface of the device. The device is characterized in that a P-type buried layer is arranged below the P-well area and above the buried oxide and is inserted into part of the P-type epitaxial layer to form a reversed L-type P-area together with the whole P-well area, and the structure can lead the hole current of the device to the bottom part so as to reduce the iron generation rate and longitudinal electric field in the channel area of the device and lower the temperature of thermion, thereby effectively inhibiting the hot carrier effect of the device.

The invention provides a traditional Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases, and aims to solve the technical problem that a traditional Chinese medicinal composition which is convenient to carry and take and can be used for effectively treating cardiovascular and cerebrovascular diseases is provided. The traditional Chinese medicinal composition for treating cardiovascular and cerebrovascular diseases is characterized by comprising the following raw materials by weight: 0.04-0.07g of bezoar, 0.5-1.5g of scorpion, 0.8-1.2g of pseudo-ginseng, 0.05-0.15g of antelope horn powder, 1-4g of ground beeltle, 0.5-1.5g of red-rooted salvia root, and 0.8-1.6g of suberect spatholobus stem. The traditional Chinese medicinal composition can be used for treating cardiovascular and cerebrovascular diseases, is small in preparation size, small in dosage and small in side effect, and is convenient to carry and take.

A release controllable film coating material targetting to colon is prepared from modified starch through adding the modified starch to coating solvent, and adding plasticizer. Its application is also disclosed.

The invention relates to a preparation method of a drug for nourishing blood, relaxing muscles and treating rheumatism. Aiming at the defects of the prior art, the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism is provided based on research about steps of a production technology and technological parameters, production cost and crude drug bioavailability. With the adoption of the preparation method of the drug for nourishing the blood, relaxing the muscles and treating the rheumatism, the defects of tedious processing procedure, long production period, high manufacturing cost, low crude drug bioavailability and higher toxic or side effects in the prior art are overcome.