19results about How to "Small dose" patented technology

This invention discloses a high-crack-resistant cement-fly ash stabilized base course material, belonging to the field of road engineering technology. The material comprises the following components by mass percentage: 2.0-3.0% cement, 16-20% fly ash, and the balance being stabilized aggregate. The cement is an external admixture, the fly ash is an internal admixture, and the gradation of the stabilized aggregate conforms to the specifications of CF-A-2L or CF-A-2S in JTG / T F20-2015. This invention, by adopting a "low cement, high fly ash" mix design, controls the 7-day unconfined compressive strength within a reasonable range of 3.5-4.5 MPa, effectively avoiding the problem of regular transverse cracks in the base course caused by excessively high early strength. Simultaneously, the high fly ash content ensures the continuous growth of the material's later strength, with its 21-day unconfined compressive strength remaining stable above 6 MPa. Its overall performance is superior to the mix ratios recommended by current standards. This invention is particularly suitable for highway base course construction in arid regions with large temperature differences, such as Xinjiang.

The application provides a kind of anaerobic digestion residue dewatering performance rapid detection method, belong to the technical field of biomass waste dewatering performance detection.Specifically: collect anaerobic digestion in 400-4000cm ‑1 Wavelength range of full-band infrared spectrum data;Using infrared spectrum analysis software to obtain the infrared spectrum data is smoothed;According to the data obtained, select 1550-1750cm ‑1 Wavelength range of infrared water spectrum data related to O-H bending vibration, Gaussian deconvolution and peak fitting are carried out using peak fitting software, and are decomposed into six sub-peaks, p1-p6;And calculate the area ratio of each sub-peak, and the ratio of the area ratio of sub-peak 1-2 and sub-peak 3-6 is represented by the sum of the area ratio of sub-peak 1-2 and sub-peak 3-6, and the value is higher, which means it is more difficult to dewater.The infrared detection method of the application has the advantages of clean, efficient, low dose, low cost, batch detection, etc.

The invention belongs to the field of biological medicine, and particularly relates to a 5 'UTR sequence and application thereof. The technical problem to be solved by the invention is to improve the expression efficiency of mRNA drugs. The main technical scheme of the invention is as follows: two 5 'UTR sequences, which are SEQ ID NO: 1 and SEQ ID NO: 2, are provided; and a nucleic acid molecule comprising the 5 'UTR sequence. Compared with a 5 'UTR sequence optimized in the nature, the mRNA constructed by the 5' UTR has the advantages that the expression efficiency of a target gene is obviously improved; the preparation method is beneficial to reducing the administration dosage and administration frequency of the mRNA drug, reducing the cost of the mRNA drug and reducing the risk of adverse reaction after administration, and has a good application prospect in the industrial production of the mRNA drug.

Disclosed herein are combination therapies for treating hematological malignancies (e.g., acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)) using an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17) and one or more chemotherapeutic agents, e.g., a Bcl2 inhibitor such as venetoclax, a hypomethylating agent (HMA), or a combination thereof.

The invention belongs to the technical field of microorganisms, and discloses a novel lactobacillus rhamnosus XB01, the preservation number of which is CGMCC (China General Microbiological Culture Collection Center) No.34941. The invention discloses a new application of the strain or metabolites thereof in preparation of products for inhibiting specific pathogenic bacteria and intervening pharyngitis. Experiments show that XB01 has a remarkable in-vitro inhibition effect on specific pathogenic bacteria and common pathogens of pharyngitis, and can effectively relieve pharyngeal inflammation of an animal model. In addition, the invention also relates to a microbial preparation containing XB01, and the microbial preparation is combined with a specific strain bifidobacterium animalis subsp. Lactis XB02 for use, and shows an unexpected synergistic effect on enhancing the sleep promoting effect. The invention provides a new technical scheme and product form for the application of the strain in the fields of functional food, medicines or health care products, especially oral and throat health and sleep improvement.

This invention discloses a class of tin-oxygen metal clusters coordinated with dialkyl and organic cyclic carboxylic acids, their synthesis, and applications. These clusters exhibit higher reactivity due to the presence of more Sn atoms and more Sn-C bond reaction sites. The tin-oxygen metal clusters have the structure of general formula I.

This invention discloses an environmentally friendly method for selectively leaching heavy rare earth elements (HREEs) from weathered crust leached rare earth ores, belonging to the fields of biometallurgy and rare earth hydrometallurgy. The method includes the following steps: activating microbial strains to obtain an activated bacterial solution; dissolving organic nitrogen and carbon sources in water to obtain a culture medium, and inoculating the activated bacterial solution to obtain a post-inoculated culture medium; adding sterilized weathered crust leached rare earth ore to the post-inoculated culture medium and conducting leaching experiments to obtain a leachate rich in HREEs; the concentration of organic nitrogen source in the culture medium is 1-2 g / L, and the concentration of carbon source is 2-10 g / L. This invention achieves a synergistic effect of selective leaching of HREEs and clean, low-ammonia nitrogen emissions through precise control of carbon and nitrogen source concentrations in the culture system, demonstrating significant industrial application value.

The invention relates to a 2, 6, 9-trisubstituted purine derivative and a synthesis method thereof, and belongs to the technical field of chemistry. The compound comprises a structure as shown in a general formula I, wherein R1 is at least one of hydrogen, C1-C6 alkyl and C3-C6 cycloalkyl; r2 and R3 are at least one of hydrogen, fluorine, chlorine, bromine, iodine, hydroxyl, amino, amino containing one or more substituent groups, cyano, C1-C6 alkoxy containing one or more substituent groups, C1-C6 alkyl acyl, C1-C6 alkyl sulfonyl, C1-C6 alkyl phosphonyl, C3-C6 heterocyclic radical and C3-C6 heterocyclic radical containing one or more substituent groups; x is an oxygen atom or a nitrogen atom. The compound disclosed by the invention is simple in synthesis step and has the characteristic of remarkably inhibiting cancer cell proliferation; the method has the advantages of high cost benefit, obvious treatment effect and low toxicity, and in the synthesis route, the yield of the intermediate is higher, and the resource consumption is effectively reduced, so that the overall cost is favorably reduced.

Embodiments described herein relate to a method for patterning a patterned stack, the method comprising forming a patterned stack over a substrate, wherein the patterned stack comprises a response layer and a resist layer over the response layer. In an embodiment, the response layer is deposited at a temperature less than 250 °C using a plasma enhanced chemical vapor deposition (PECVD) process. In an embodiment, the process further comprises forming openings in the resist layer and transferring a pattern of the openings into the response layer. In an embodiment, the response layer has a first line width roughness (LWR). In an embodiment, the method further comprises reflowing the response layer to form a reflowed response layer, wherein the reflowed response layer has a second LWR that is less than the first LWR.

The invention discloses ship ballast water treatment equipment, and belongs to the field of sewage treatment.The ship ballast water treatment equipment comprises a treatment part, the treatment part comprises a rotational flow part, a tangential liquid inlet formed in the outer wall of the rotational flow part, a sand settling opening formed in the lower end of the rotational flow part and an overflow pipe fixed to the inner wall of the rotational flow part; the upper end of the overflow pipe is fixedly connected with the inner wall of the rotational flow part; the filter cartridge is arranged at the contraction section of the overflow pipe, and when the second liquid discharge connector is closed, liquid forcibly entering the overflow pipe passes through the filter cartridge, so that small organisms which cannot be separated by cyclone are intercepted; a first spiral flow guide flange in the expansion section can force fluid to rotate at a high speed when the fluid enters the overflow pipe, so that water flow in the contraction section is tangentially swept along the surface of the filter cartridge, and silt and organisms which attempt to be attached to the filter cartridge are continuously stripped off; the effective working time of the filter cartridge is prolonged, and the differential pressure rising speed is slowed down.

This utility model relates to the field of colloidal gold test strip technology, specifically a colloidal gold test strip for rapid detection of Seneca virus antibodies, comprising a bottom shell and an upper shell, which are snapped together to form a box body. The upper surface of the bottom shell has a test strip mounting groove, inside which are respectively arranged an adsorption membrane, a conjugate pad, an NC membrane, and absorbent filter paper. A liquid accumulation groove is located at the bottom of the test strip mounting groove, and a liquid inlet groove is located on the side of the liquid accumulation groove. In use, by setting a liquid accumulation groove at the bottom of the test strip mounting groove corresponding to the dropper opening, and setting a liquid inlet groove on the side of the liquid accumulation groove so that the liquid inlet strip extends into the liquid inlet groove, after the liquid sample is dripped in through the dropper opening, the adsorption membrane adsorbs the sample liquid through capillary action. Part of the sample liquid is transported to the colloidal gold through the adsorption membrane, and part of the sample liquid permeates into the liquid accumulation groove and is directly adsorbed by the liquid inlet strip. By increasing the adsorption area, the detection efficiency is improved.

This invention discloses the application of an inhibitor of the BEX4-XRCC5 interaction in the preparation of an anti-hepatoblastoma drug, belonging to the field of biomedical technology. The inhibitor, F35-303, specifically disrupts the direct interaction between BEX4 and XRCC5 proteins, inhibiting the DNA non-homologous end joining repair pathway, thereby targeting hepatoblastoma tumor stem cells and overcoming the limitations of existing therapies. It is particularly suitable for treating platinum-resistant or recurrent hepatoblastoma. The inhibitor is a small molecule compound named F35-303. This invention also provides pharmaceutical compositions containing this inhibitor and their combination therapy with platinum-based chemotherapy drugs (such as cisplatin), which can synergistically enhance efficacy and reduce toxic side effects. This invention provides a novel targeted therapy strategy for hepatoblastoma.

Inhalation formulations of relacorilant, their production and their use are provided.

Disclosed herein is a method for generating a calibrated pseudo-CT image of at least a portion of a patient for a radiation therapy plan. The method includes obtaining radiation intensity data indicative of attenuation properties of tissue within the patient; and calibrating a first pseudo-CT image of at least a portion of the patient using the radiation intensity data to generate a calibrated pseudo-CT image.

The embodiment of the present application provides an endoscope connector and an endoscope, which comprise an insulating shell and a plurality of electric contact pins. The insulating shell comprises an insulating base. The insulating base has a mating surface and a mounting surface which are opposite to each other along a mating direction. The mounting surface is provided with a glue groove which is recessed inward. The plurality of electric contact pins are fixed to the insulating base and located in the glue groove, and the electric contact pins comprise contact ends and connecting ends located at two ends. The contact ends extend to the mating surface and are exposed to the mating surface; the connecting ends extend to the outside of the mounting surface, and the insulating base is injection molded on the plurality of electric contact pins. The glue groove is filled with sealing glue, and the thickness of the sealing glue is not more than the depth of the glue groove. The insulating base is injection molded around the electric contact pins, so that the electric contact pins are tightly combined with the insulating base, the precision of all the electric contact pins on the endoscope connector is high, and the consistency is good. The waterproofness, heat resistance and chemical resistance of the components are ensured by arranging the glue groove on the mounting surface and filling the sealing glue.

The application belongs to the technical field of zeolite molecular sieve synthesis, and particularly relates to a method for synthesizing SSZ-39 molecular sieve and application. The synthesis method comprises the following steps: uniformly stirring a template agent, water, an alkali source, an amorphous silicon source and an amorphous aluminum source, uniformly stirring the pH regulator after adding the pH regulator, uniformly stirring the SSZ-39 molecular sieve seeds, obtaining an initial gel, and then sequentially performing crystallization treatment, filtration, washing, drying and calcination to obtain a Na type molecular sieve. The application uses conventional silicon sources and aluminum sources, starts from amorphous raw materials, and adds a small amount of crystal seeds for assistance, thereby avoiding the use of expensive FAU type molecular sieve in the traditional synthesis SSZ-39 molecular sieve conversion method, realizing low-cost synthesis of the SSZ-39 molecular sieve and obtaining a high yield, and for the first time, the amorphous raw material directly synthesizes the SSZ-39 molecular sieve with a yield of more than 72%. After Cu modification, the obtained molecular sieve sample exhibits excellent catalytic performance and high hydrothermal stability in the NH3-SCR reaction.

This application proposes the application and method of oryzanol and naphthaleneacetic acid or their salts in promoting cucumber growth. The combined use of oryzanol and naphthaleneacetic acid or their salts can effectively promote cucumber growth, increase the weight and yield of cucumber fruits, and improve cucumber quality, avoiding undesirable phenomena such as uneven cucumber size, easy bending, and deformed fruits. It is suitable for widespread application.

The utility model belongs to the technical field of beam limiter, specifically relates to a beam limiter additional filter device, including filter assembly and motor, filter assembly includes the base plate, one end of base plate is equipped with the mounting hole, is equipped with the filter piece on the mounting hole, the other end of base plate is equipped with the shaft sleeve, the shaft sleeve is connected with motor, and motor is used for driving base plate to rotate with the shaft sleeve as the center, when using, make filter piece cover the ray export of beam limiter through motor drive filter assembly rotation, filter harmful rays, simple, fast, and the whole device structure is simple, small, can save the installation space, is favorable to the miniaturization design of beam limiter.

The utility model relates to an accurate fixing device for a photoelectric module of a nuclear power plant control area access monitoring system, which is used for accurately positioning a personnel, vehicle and equipment photoelectric module of the control area access monitoring system and improving the accuracy of personnel and vehicle radiation monitoring equipment. Comprising a stainless steel support with a semicircular groove, a photoelectric module is arranged in the semicircular groove, a long-strip-shaped hole is formed in the support, and the fixing position of the support is adjusted through a positioning bolt in the hole. And the photoelectric module is fixed with the original photoelectric base of the personnel and vehicle monitor body through the device. The hole and the personnel and vehicle monitor body are locked through a bolt. According to the utility model, the working convenience and the stability / effectiveness of equipment monitoring are ensured in practical application.