9results about How to "Small dose" patented technology

This invention discloses a high-crack-resistant cement-fly ash stabilized base course material, belonging to the field of road engineering technology. The material comprises the following components by mass percentage: 2.0-3.0% cement, 16-20% fly ash, and the balance being stabilized aggregate. The cement is an external admixture, the fly ash is an internal admixture, and the gradation of the stabilized aggregate conforms to the specifications of CF-A-2L or CF-A-2S in JTG / T F20-2015. This invention, by adopting a "low cement, high fly ash" mix design, controls the 7-day unconfined compressive strength within a reasonable range of 3.5-4.5 MPa, effectively avoiding the problem of regular transverse cracks in the base course caused by excessively high early strength. Simultaneously, the high fly ash content ensures the continuous growth of the material's later strength, with its 21-day unconfined compressive strength remaining stable above 6 MPa. Its overall performance is superior to the mix ratios recommended by current standards. This invention is particularly suitable for highway base course construction in arid regions with large temperature differences, such as Xinjiang.

The application provides a kind of anaerobic digestion residue dewatering performance rapid detection method, belong to the technical field of biomass waste dewatering performance detection.Specifically: collect anaerobic digestion in 400-4000cm ‑1 Wavelength range of full-band infrared spectrum data;Using infrared spectrum analysis software to obtain the infrared spectrum data is smoothed;According to the data obtained, select 1550-1750cm ‑1 Wavelength range of infrared water spectrum data related to O-H bending vibration, Gaussian deconvolution and peak fitting are carried out using peak fitting software, and are decomposed into six sub-peaks, p1-p6;And calculate the area ratio of each sub-peak, and the ratio of the area ratio of sub-peak 1-2 and sub-peak 3-6 is represented by the sum of the area ratio of sub-peak 1-2 and sub-peak 3-6, and the value is higher, which means it is more difficult to dewater.The infrared detection method of the application has the advantages of clean, efficient, low dose, low cost, batch detection, etc.

The invention belongs to the field of biological medicine, and particularly relates to a 5 'UTR sequence and application thereof. The technical problem to be solved by the invention is to improve the expression efficiency of mRNA drugs. The main technical scheme of the invention is as follows: two 5 'UTR sequences, which are SEQ ID NO: 1 and SEQ ID NO: 2, are provided; and a nucleic acid molecule comprising the 5 'UTR sequence. Compared with a 5 'UTR sequence optimized in the nature, the mRNA constructed by the 5' UTR has the advantages that the expression efficiency of a target gene is obviously improved; the preparation method is beneficial to reducing the administration dosage and administration frequency of the mRNA drug, reducing the cost of the mRNA drug and reducing the risk of adverse reaction after administration, and has a good application prospect in the industrial production of the mRNA drug.

Disclosed herein are combination therapies for treating hematological malignancies (e.g., acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS)) using an antibody that binds human galectin-9 (anti-Gal9 antibody, e.g., G9.2-17) and one or more chemotherapeutic agents, e.g., a Bcl2 inhibitor such as venetoclax, a hypomethylating agent (HMA), or a combination thereof.

This invention discloses an environmentally friendly method for selectively leaching heavy rare earth elements (HREEs) from weathered crust leached rare earth ores, belonging to the fields of biometallurgy and rare earth hydrometallurgy. The method includes the following steps: activating microbial strains to obtain an activated bacterial solution; dissolving organic nitrogen and carbon sources in water to obtain a culture medium, and inoculating the activated bacterial solution to obtain a post-inoculated culture medium; adding sterilized weathered crust leached rare earth ore to the post-inoculated culture medium and conducting leaching experiments to obtain a leachate rich in HREEs; the concentration of organic nitrogen source in the culture medium is 1-2 g / L, and the concentration of carbon source is 2-10 g / L. This invention achieves a synergistic effect of selective leaching of HREEs and clean, low-ammonia nitrogen emissions through precise control of carbon and nitrogen source concentrations in the culture system, demonstrating significant industrial application value.

This invention discloses the application of an inhibitor of the BEX4-XRCC5 interaction in the preparation of an anti-hepatoblastoma drug, belonging to the field of biomedical technology. The inhibitor, F35-303, specifically disrupts the direct interaction between BEX4 and XRCC5 proteins, inhibiting the DNA non-homologous end joining repair pathway, thereby targeting hepatoblastoma tumor stem cells and overcoming the limitations of existing therapies. It is particularly suitable for treating platinum-resistant or recurrent hepatoblastoma. The inhibitor is a small molecule compound named F35-303. This invention also provides pharmaceutical compositions containing this inhibitor and their combination therapy with platinum-based chemotherapy drugs (such as cisplatin), which can synergistically enhance efficacy and reduce toxic side effects. This invention provides a novel targeted therapy strategy for hepatoblastoma.

The embodiment of the present application provides an endoscope connector and an endoscope, which comprise an insulating shell and a plurality of electric contact pins. The insulating shell comprises an insulating base. The insulating base has a mating surface and a mounting surface which are opposite to each other along a mating direction. The mounting surface is provided with a glue groove which is recessed inward. The plurality of electric contact pins are fixed to the insulating base and located in the glue groove, and the electric contact pins comprise contact ends and connecting ends located at two ends. The contact ends extend to the mating surface and are exposed to the mating surface; the connecting ends extend to the outside of the mounting surface, and the insulating base is injection molded on the plurality of electric contact pins. The glue groove is filled with sealing glue, and the thickness of the sealing glue is not more than the depth of the glue groove. The insulating base is injection molded around the electric contact pins, so that the electric contact pins are tightly combined with the insulating base, the precision of all the electric contact pins on the endoscope connector is high, and the consistency is good. The waterproofness, heat resistance and chemical resistance of the components are ensured by arranging the glue groove on the mounting surface and filling the sealing glue.

This application proposes the application and method of oryzanol and naphthaleneacetic acid or their salts in promoting cucumber growth. The combined use of oryzanol and naphthaleneacetic acid or their salts can effectively promote cucumber growth, increase the weight and yield of cucumber fruits, and improve cucumber quality, avoiding undesirable phenomena such as uneven cucumber size, easy bending, and deformed fruits. It is suitable for widespread application.

The utility model belongs to the technical field of beam limiter, specifically relates to a beam limiter additional filter device, including filter assembly and motor, filter assembly includes the base plate, one end of base plate is equipped with the mounting hole, is equipped with the filter piece on the mounting hole, the other end of base plate is equipped with the shaft sleeve, the shaft sleeve is connected with motor, and motor is used for driving base plate to rotate with the shaft sleeve as the center, when using, make filter piece cover the ray export of beam limiter through motor drive filter assembly rotation, filter harmful rays, simple, fast, and the whole device structure is simple, small, can save the installation space, is favorable to the miniaturization design of beam limiter.