470 results about "Micro particles" patented technology

The invention provides an efficient oil reservoir yield increasing fracturing method based on a micro-particle-size echelon proppant and application of the efficient oil reservoir yield increasing fracturing method, and belongs to the technical field of oil field yield increasing. According to the method, fracturing parameters are optimized by controlling the particle size and the filling sequence of the proppant and combining an intelligent algorithm, and efficient yield increase of the oil reservoir is achieved. The method comprises the specific steps that proppants with different particle sizes are selected according to stratum characteristics, fluid flowing rules and fracturing targets; designing a particle size gradient filling sequence of the proppant; fracturing parameters are optimized through an intelligent algorithm; fracturing operation is carried out, and the crack is filled with a propping agent; monitoring crack propagation, propping agent filling and fluid flowing conditions in real time, and adjusting fracturing parameters and a filling sequence; after the fracturing operation is completed, the fracturing effect is evaluated, and the propping agent selection, the filling sequence and the fracturing parameters are further optimized. According to the efficient oil reservoir yield increasing fracturing method based on the micro-particle-size echelon proppant and the application of the efficient oil reservoir yield increasing fracturing method, the yield increasing effect of an oil reservoir can be remarkably improved, and the method has wide application prospects.

The invention provides a decellularized dermal matrix particle and a preparation method thereof, the preparation method comprises the steps of pretreatment, degreasing, virus inactivation, decellularization, grinding, crosslinking, freeze-drying and sterilization subpackaging, and solves the problems that the existing decellularized particle product is non-uniform in particle size, incomplete in decellularization, poor in injection effect and incapable of meeting the requirements of tissue repair and regeneration. The invention develops a product which is short in production cycle, relatively concentrated in particle size distribution, thorough in cell removal and complete in matrix function preservation, can effectively remove fat and viruses in animal skin, and has the advantages of being thorough in decellularization, short in time, high in efficiency, light in damage to dermal matrix, capable of removing antigens, capable of retaining a natural structure and capable of effectively guiding tissue regeneration. When the temperature of the freeze-dried particle dispersion liquid is reduced, the water binding capacity of the particles is reduced, free water in the prepared solution is increased, the particles naturally float and gather (dense at the upper part and sparse at the lower part), and the free water is in the lower layer and still has good dispersity after being sterilized.

The invention discloses a real-time early warning method and system for precise mold production and processing, and relates to the technical field of mold processing, and the method comprises the steps: when a residual pressure disturbance energy aggregation function F1 exceeds a disturbance threshold Q1, the system automatically switches to a trend tracking mode, further calculates and outputs a flow velocity abrupt change rate variation factor F2 and a composite migration pressure difference index F3, and then outputs a flow velocity abrupt change rate variation factor F3; through second-order flow velocity derivative analysis and particle-heat flow-pressure difference coupling behavior modeling, a complex blocking trend caused by particle deposition, heat stagnation accumulation and countercurrent disturbance is effectively identified. And calculating a blockage risk index Irisk by combining the two indexes, and setting a first blockage threshold W1 and a second blockage threshold W2 to realize automatic evaluation and classified response of different blockage levels. Compared with an existing mode of only judging a single parameter of pressure, the method can analyze a blockage evolution path in multiple dimensions and output a grading result, and the risk controllability and the strategy adjustment elasticity are enhanced.

The present invention provides a colloidal silica having few fine particles. Also provided is a method for producing a colloidal silica.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention discloses a magnetic particle chemiluminiscence detection kit for human non-phosphorylated Tau217 protein and a preparation method of the magnetic particle chemiluminiscence detection kit. The kit comprises a micro magnetic particle coupled with a human non-phosphorylated Tau217 protein capture antibody, an acridinium ester labeled human non-phosphorylated Tau217 protein detection antibody, a human non-phosphorylated Tau217 protein calibration product and a quality control product. The direct chemiluminescence method established by the invention has the advantages of high sensitivity, strong specificity, accuracy, rapidness and short detection time, the detection result has higher accuracy and repeatability, and the kit can be used for various luminescence detection instruments.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention relates to a method for evaluating and debugging a sterile pipeline for food and beverage processing, which comprises the following steps of: introducing standardized sterile gas into a closed pipeline system to establish a micro-positive pressure environment; detecting a pressure change curve of each node of the system in real time by using a micro-differential pressure sensing module; calculating the position and the size of a trace leakage point; recording the motion trail of the particles in the pipeline by using a dynamic particle imaging system PIV; flow dead angles are identified through trajectory analysis, and the potential pollution accumulation area of the retention area marks the pollution accumulation probability of each section of pipeline in a quantitative mode; preparing simulation liquid, and adding biomarker particles to enable the viscosity and the fluidity of the target beverage to be close to those of the target beverage; according to the identified potential pollution accumulation area, local directional pouring is carried out; full-process automatic data acquisition, model judgment and debugging instruction issuing can be realized, manual intervention is greatly reduced, the system stability is improved, and the system is suitable for various food and beverage production scenes.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention discloses a full-automatic chemiluminiscence detection reagent for a porcine reproductive and respiratory syndrome virus N antibody and application of the full-automatic chemiluminiscence detection reagent, and belongs to the technical field of biology. The detection reagent comprises a serum diluent, a first reagent and a second reagent, the first reagent comprises magnetic particles coated with porcine reproductive and respiratory syndrome virus N protein; and the second reagent comprises an acridinium ester labeled anti-pig antibody. The kit can accurately detect the porcine reproductive and respiratory syndrome virus N antibody, is high in sensitivity, good in specificity, strong in interference resistance, high in precision, short in reaction time, simple to operate and automatic, provides material guarantee and technical support for prevention and control of porcine reproductive and respiratory syndrome, and has important significance.

A method for removing particles from water, the method comprising: supplying gelatinous zooplankton mucus to water comprising particles; allowing formation of particle aggregates in the water by allowing interaction between the particles in the water and the gelatinous zooplankton mucus; removing the particle aggregates from the water by passing the water comprising particle aggregates through a filter configured to receive water comprising particle aggregates and further filter the water; and exiting filtered water from the filter. A system for removing particles from water with the aforementioned method is also provided. Additional embodiments of the system and method for removing particles from water are disclosed herein.

Nano- and micro-particles (NMP) can be formed from an oil / water emulsion. The emulsion is made by mixing a liquid solvent, at least one surfactant, a particle-forming compound, and at least curing agent. If desired, pH control agents and viscosity enhancers can be added to the liquid solvent. The particle-forming compound and the curing agents are mixed together and form the oil phase in the emulsion and after curing, the particles are formed. The nano- and micro-particles can be used as proppant to enhance the conductivity of nano- and microfractures and fluid-loss-control additive for hydraulic fracturing operations.

The invention belongs to the technical field of multifunctional composite seed coatings for ecological restoration of high and cold regions, discloses a Qinghai cold-region bluegrass seed coating agent and a preparation method thereof, and aims to solve the composite problems of component antagonism, time sequence mismatch, freeze-thaw failure and the like in the prior art. The coating agent is characterized in that a three-layer composite structure of a biological core layer, a nutrition buffer layer and a functional protection layer is sequentially coated on the surface of a seed from inside to outside. The biological core layer comprises complex microbial inoculant particles and a first adhesive; the nutrition buffer layer comprises a low-temperature germination inducer, a slow-release nutrition microcapsule and a second adhesive; the functional protection layer comprises an interpenetrating network polymer skeleton, high molecular weight sodium alginate, nano silicon dioxide particles subjected to surface modification by a silane coupling agent KH-570 and food-grade indigo dye. By means of the scheme, efficient germination and stable planting of the Qinghai cold land bluegrass seeds in the high and cold environment are achieved.

The invention discloses a water glass-based full-life super-amphiphobic radiation refrigeration block material, which is prepared from the following raw materials in parts by weight: 1.5 to 3 parts of C-F long-chain modified micro-nano particles, 0.5 to 1.5 parts of water glass-based binder, 0.1 to 0.3 part of nano silicon dioxide sol and 0.05 to 0.16 part of curing catalyst, the C-F long-chain modified micro-nano particles are obtained by sequentially carrying out silane coupling agent grafting modification and fluorosilane grafting modification on nano particles with high sunlight reflectivity and micro particles with high sunlight emissivity. The super-amphiphobic function is converted into a three-dimensional block material from a two-dimensional coating, stress distribution optimization and interface bonding energy improvement are achieved while the ultra-low surface energy characteristic is kept, the problems of optical performance degradation and the like caused by surface pollution of the radiation refrigeration material are effectively solved, the mechanical durability of the material is essentially improved, and the service life of the radiation refrigeration material is prolonged. And the radiation refrigeration system can maintain stable performance in the whole life cycle.

Provided is a composition for controlling uptake of microparticles into a body, the composition containing a lactic acid bacterium. The lactic acid bacterium is preferably any one selected from bacteria belonging to the genus Lactobacillus and bacteria belonging to the genus Streptococcus. For example, the lactic acid bacterium is a bacterium belonging to Lactobacillus delbrueckii, Lactobacillus paracasei, Lactobacillus gasseri, or Streptococcus thermophilus.

The invention discloses an electromagnetic shielding cable for a radio altimeter and a preparation method thereof, and relates to the technical field of cables. The preparation method comprises the following steps: treating ethylene-tetrafluoroethylene copolymer particles, a mixed compatilizer, a chemical foaming agent and a nano nucleating agent by using mixed gas low-temperature plasma containing acrylic acid, performing melt blending by using a double-screw extruder, injecting supercritical carbon dioxide, and performing slow cooling and shock cooling to obtain a three-dimensional porous matrix containing micro-nano cells; the preparation method comprises the following steps: synthesizing ferroferric oxide particles by a solvothermal method, coating a silicon dioxide dielectric layer, and then chemically silvering to prepare ternary core-shell composite particles; modifying the particles with aminopropyltriethoxysilane and a block copolymer to obtain modified composite particles; melting, mixing and granulating the porous matrix and the modified composite particles to obtain the electromagnetic shielding composite material. And performing extrusion molding on a conductor to form an insulation shielding layer, thereby obtaining the cable. The cable has an excellent electromagnetic shielding effect.

According to the Tesla valve structure-imitated micro-flow controller and the preparation method thereof, improvement design is carried out on the basis of an existing Tesla valve structure, the pipe wall of a first branch straight pipe section is designed to be of an arc-shaped structure, the area is increased by 20%-30%, a sawtooth-shaped structure is arranged on the pipe wall, a tiny cavity is additionally formed in a second branch straight pipe section, and the area of the first branch straight pipe section is increased by 20%-30%; the diameter of the structure of the shunting section is modified to be gradually increased, so that the cross sectional area of the shunting section is expanded by 25%-30%, the inner diameter of the branch annular section is reduced, the outer diameter of the branch annular section is expanded, the area of the expanded branch annular section is increased by 25%-35%, and the length of the outlet section is prolonged to be 30%-40% of the original length. The micro-flow controller with the imitated Tesla valve structure prepared by the invention can effectively guide fluid to flow, reduce accumulation of micro-particles in a micro-channel and enhance the impurity particle embolism resistance of a system, so that the stability and reliability of the whole system are improved.

The invention provides a water-based suspension pesticide composition. The water-based suspension pesticide composition comprises the following components: a solvent deionized water; based on the mass of the solvent, the core-shell structure active particles account for 0.5-20w%; based on the mass of the solvent, 0.01-5w% of a suspension stabilizer; the core-shell structure active particles are humidity response microspheres resistant to acid and alkali, the core-shell structure active particles are used, intermolecular acting force is reduced, particle agglomeration is reduced, dispersity of active ingredients is improved, a natural polymer material is adopted as a shell, biocompatibility is good, biodegradability is achieved, pollution to the environment is reduced, and the core-shell structure active particles are environmentally friendly. Meanwhile, the PEG-PCL block copolymer is introduced, so that the pesticide release rate can be accurately controlled according to the environment humidity change, and the pesticide utilization rate is increased. Moreover, the chitosan-sodium alginate composite gel of the particle shell layer is stably and slowly released in neutral and weakly alkaline soil, in acidic and strongly alkaline environments, the microspheres are prevented from collapsing, the stability of the particle slow-release system in soil with different PH values is improved, and the application range of the active particles is expanded.

The utility model discloses a single particle mechanical property test system, which can realize the whole process of observing and detecting micro particles from being extruded to a crushing state, and comprises a test frame, an objective table, a glass slide, a pressure head, an objective lens, a lower light source, an eyepiece, an imaging device and a refraction single lens, the objective table is mounted on the test frame in an X-Y axis adjustable manner, and is provided with a through hole; the glass slide stretches across the through hole and is used for placing a particle sample to be tested; the pressure head is matched above the objective table in a lifting manner along the Z-axis direction; the objective lens is arranged below the through hole; the lower light source is arranged on the side below the objective lens; the eyepiece is arranged on the surface of the test frame; the imaging device is arranged in the test frame; the refraction single lens is arranged below the objective lens, and the reflection surface of the refraction single lens simultaneously faces the objective lens and the imaging device; the refraction single lens refracts light emitted by the lower light source to the direction of the objective lens, the light in the direction of the objective lens is reflected to the imaging device through the reflection face, and the imaging device presents collected images on the eyepiece.

To solve the problem that in the conventional technique, measurement-target solution for use in an electrochemical immunity measurement method is not buffer solution, therefore the pH of the measurement-target solution is not stabilized.SOLUTION: A method for measuring a measurement-target is provided, for inspecting presence / absence or density of the measurement-target, the method comprises: a washing step in which a working electrode to which an immune composite including the measurement-target is fixed, is washed by washing buffer solution; and a current measuring step in which a current value is measured by controlling a potential of the working electrode in the washing buffer solution. The immune composite includes: the measurement-target; a first coupled object specifically coupled to the measurement-target; a second coupled object specifically coupled to the measurement-target; and a labeled substance coupled to the second coupled object, the labeled substance is metal fine particles, and pH of the washing buffer solution is 4 to 6.SELECTED DRAWING: Figure 3

This invention describes microcapsule compositions and methods to encapsulate gas modulating enzymes or nanozymes at unprecedented concentrations and stability, that can be used to regulate the local gas concentrations. Microcapsules can be comprised of gelatin with a polydopamine coating. This system can replace expensive incubators / chambers and is the first system that can create spatiotemporal gradients of gases within a finite volume. The microcapsules have a broad range of applications in tissue culture, bioprinting, in vivo, and industrial uses.

Disclosed in the present invention are an aqueous triggered controlled-release saline-alkali soil conditioner and a preparation method therefor. The aqueous triggered controlled-release saline-alkali soil conditioner comprises agent A. The agent A comprises a water-soluble polymer and controlled-release suspended particles. The controlled-release suspended particles comprise alginate / anti-reverse regulator composite particulates. The alginate / anti-reverse regulator composite particulates are obtained by sequentially subjecting an alginate to two-step gel cross-linking by means of a cationic anti-reverse regulator and a high-valent metal ion-containing cross-linking agent. In the present invention, the alginate used as a main material is subjected to charged regulator-based high-speed dispersion for primary gelation and high-valent metal-based secondary gelation, thereby preparing a micron-nano powder and suspension, and incorporating a solvable organic polymer material, the functions of graded release and intelligent regulation of a product are achieved. The incorporation of an organic acid and a phosphoric acid material can not only prevent a micro-irrigation device from scaling but can also achieve triggered controlled-release of the material on demand and in a timely manner, thereby achieving the effects of multi-particle-size dispersion and precise release of the product in soil.

The invention relates to the technical field of water treatment, in particular to a method for treating degradation-resistant organic pollution underground water based on a micro-interface strengthening technology. According to the technical scheme, the method comprises the steps that an underground water sample is collected and subjected to pollution characteristic analysis, composite material slurry is injected into a water-containing layer to construct an interface-enhanced in-situ reaction system, and the slurry is composed of nanoscale iron-based metal particles, graphene oxide derivatives, modified biochar, a surfactant and the like; meanwhile, a low-pressure gas injection system is arranged to form a micro-aerobic environment so as to improve the interface reaction efficiency, dominant microbial communities are synchronously injected, a slow-release carbon source carrier is added so as to strengthen the biological synergistic degradation effect, and the operation state of the system is regulated and controlled through multi-parameter monitoring. According to the method, a micro-interface synergistic system integrating physical adsorption, chemical reduction and biological metabolism is constructed, refractory organic pollutants such as aryl halide and polycyclic aromatic hydrocarbon in underground water can be efficiently and stably removed, and the method has the advantages of being high in remediation efficiency, high in operation stability and wide in environmental adaptability.

The invention discloses a preparation method of a silicon-titanium composite particle with a raspberry-shaped structure, which comprises the following steps: compounding nano-scale silicon dioxide and titanium dioxide according to a certain ratio, and carrying out spray granulation to obtain the silicon-titanium composite particle. After light rays are incident, the light rays are subjected to multiple scattering due to aggregation and stacking of the microparticles, and the particles with the raspberry-shaped structures have a soft focus effect due to reflection and transmission of the surfaces and the internal particles of the particles. The high-refractive-index titanium dioxide uniformly distributed in the particles can improve the light diffusion effect and improve the sunscreen performance of the particles at the same time. The method has the characteristics of simplicity and convenience in operation, easiness in obtaining raw materials, high biocompatibility and the like, and has a wide application prospect in the field of cosmetics.

Provided herein is a coated particle comprising: (i) a microparticle that comprises a pharmaceutically acceptable excipient and (ii) nanoparticles of a therapeutic agent, wherein the surface of the microparticle is coated with the nanoparticles. Also provided herein is a pharmaceutical composition comprising the coated particle. Furthermore, provided herein are methods of their preparation.

The embodiment of the invention discloses a composite water-light for injection and a preparation method thereof. The composite water-light for injection is prepared from the following raw materials in parts by weight: 30-60 parts of nano poly-L-lactic acid particles and 10-30 parts of sodium hyaluronate. By screening the components, the provided composite hyaluronic acid hydrogel has the advantages of long duration of water and light, uniform particles, good dispersibility, stronger dispersibility in tissues and good needle passing performance, solves the problems of short effect maintenance period, unobvious improvement effect and the like of the traditional hyaluronic acid hydrogel product, and provides a new choice for the field of medical cosmetology.

The application provides a low-crystallinity hydroxyapatite microsphere for implantation and a preparation method thereof, and the preparation method comprises the following steps: preparing a mixed solution of a calcium source reagent and a phosphorus source reagent, adding inorganic acid, alkali and a buffer into the mixed solution, adding a surfactant, and obtaining a hydroxyapatite micro-particle precipitate through constant-temperature reaction; cleaning the hydroxyapatite micro-particle precipitate, and preparing a hydroxyapatite micro-particle suspension by adding water; and performing spray drying on the hydroxyapatite micro-particle suspension to obtain the hydroxyapatite microsphere; wherein the surfactant is one or more of PEG and PVP. The hydroxyapatite microsphere obtained by the application has stable structure, belongs to spherical large particles, is easy to inject, and is not prone to agglomeration; when the hydroxyapatite microsphere is injected into a human body, the hydroxyapatite microsphere has good supporting effect; and the preparation method of the application is simple, has few process steps, and is easy to realize reaction conditions, and is suitable for large-scale production.

The invention relates to the technical field of pesticide preparations, and discloses a pesticide preparation containing Se-CDs, benzylaminopurine and triacontanol, the pesticide preparation is a nanometer suspending agent prepared from benzylaminopurine raw medicine, triacontanol raw medicine, a Se-CDs nanometer material and an auxiliary agent, and the particle size D90 of solid particles in the nanometer suspending agent is smaller than or equal to 800 nm; the auxiliary agent comprises a wetting dispersant, a thickening agent, a rheological agent, an anti-freezing agent, a preservative, a defoaming agent and deionized water, and the wetting dispersant is composed of an anionic-nonionic wetting dispersant SP-SC3219 and a weak cationic wetting dispersant SP-SC3275. According to the invention, the problems of large grinding particle size and long grinding time of a pesticide composition containing benzylaminopurine in the preparation and grinding process of a suspending agent and the problem of unstable fusion of Se-CDs with nano particle size and a suspending agent with micron particle size are solved, and the particle size stability and appearance stability of the preparation are improved.

The invention relates to the technical field of food safety detection, in particular to solid-phase extraction filler for detecting pesticide residues in food and a preparation method and application thereof.The solid-phase extraction filler comprises a magnetic filler core and a selective adsorption layer wrapping the magnetic filler core; wherein the interior of the magnetic filler core at least comprises magnetic particles and a coating layer for improving the stability of the magnetic particles; the selective adsorption layer is composed of a porous organic framework material which is chemically grafted outside the coating layer; and a temperature-sensitive polymer gel layer also covers the outer part of the selective adsorption layer. According to the solid-phase extraction filler disclosed by the invention, through an innovative hierarchical structure design, the extraction of trace pesticide residues in food can be effectively improved, the extraction difficulty is reduced, and the extraction efficiency and the extraction selectivity are improved.

The invention belongs to the field of biomedical materials and tissue engineering, and particularly relates to an injectable mineralized collagen bone repair composite material loaded with stem cell recruitment factors and osteogenic induction factors and a preparation method of the injectable mineralized collagen bone repair composite material. The composite material is composed of 50%-53% of mineralized collagen matrix particles, 15%-20% of SDF-1alpha loaded heparinized gelatin microspheres, 15%-20% of BMP-2 loaded PDA coated mesoporous silica particles, 8%-10% of an NHS-PEG-NHS cross-linking agent and 4%-6% of glycerin. The composite material can realize time-space sequential regulation and control of'collection first and then differentiation '; a bionic bone matrix microenvironment is provided through the mineralized collagen matrix; the problems of two-factor release conflict and stability are solved; in-vitro experiments show that the material can significantly promote stem cell migration and osteogenic differentiation, and animal experiments prove that the material can recover 82-88% of mechanical properties of bone defect parts. The invention solves the technical problems of insufficient stem cell collection, low osteogenic differentiation efficiency and uncontrollable factor release of the existing bone repair material.