382 results about "Micro particles" patented technology

The invention provides a decellularized dermal matrix particle and a preparation method thereof, the preparation method comprises the steps of pretreatment, degreasing, virus inactivation, decellularization, grinding, crosslinking, freeze-drying and sterilization subpackaging, and solves the problems that the existing decellularized particle product is non-uniform in particle size, incomplete in decellularization, poor in injection effect and incapable of meeting the requirements of tissue repair and regeneration. The invention develops a product which is short in production cycle, relatively concentrated in particle size distribution, thorough in cell removal and complete in matrix function preservation, can effectively remove fat and viruses in animal skin, and has the advantages of being thorough in decellularization, short in time, high in efficiency, light in damage to dermal matrix, capable of removing antigens, capable of retaining a natural structure and capable of effectively guiding tissue regeneration. When the temperature of the freeze-dried particle dispersion liquid is reduced, the water binding capacity of the particles is reduced, free water in the prepared solution is increased, the particles naturally float and gather (dense at the upper part and sparse at the lower part), and the free water is in the lower layer and still has good dispersity after being sterilized.

The invention discloses a real-time early warning method and system for precise mold production and processing, and relates to the technical field of mold processing, and the method comprises the steps: when a residual pressure disturbance energy aggregation function F1 exceeds a disturbance threshold Q1, the system automatically switches to a trend tracking mode, further calculates and outputs a flow velocity abrupt change rate variation factor F2 and a composite migration pressure difference index F3, and then outputs a flow velocity abrupt change rate variation factor F3; through second-order flow velocity derivative analysis and particle-heat flow-pressure difference coupling behavior modeling, a complex blocking trend caused by particle deposition, heat stagnation accumulation and countercurrent disturbance is effectively identified. And calculating a blockage risk index Irisk by combining the two indexes, and setting a first blockage threshold W1 and a second blockage threshold W2 to realize automatic evaluation and classified response of different blockage levels. Compared with an existing mode of only judging a single parameter of pressure, the method can analyze a blockage evolution path in multiple dimensions and output a grading result, and the risk controllability and the strategy adjustment elasticity are enhanced.

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention relates to a method for evaluating and debugging a sterile pipeline for food and beverage processing, which comprises the following steps of: introducing standardized sterile gas into a closed pipeline system to establish a micro-positive pressure environment; detecting a pressure change curve of each node of the system in real time by using a micro-differential pressure sensing module; calculating the position and the size of a trace leakage point; recording the motion trail of the particles in the pipeline by using a dynamic particle imaging system PIV; flow dead angles are identified through trajectory analysis, and the potential pollution accumulation area of the retention area marks the pollution accumulation probability of each section of pipeline in a quantitative mode; preparing simulation liquid, and adding biomarker particles to enable the viscosity and the fluidity of the target beverage to be close to those of the target beverage; according to the identified potential pollution accumulation area, local directional pouring is carried out; full-process automatic data acquisition, model judgment and debugging instruction issuing can be realized, manual intervention is greatly reduced, the system stability is improved, and the system is suitable for various food and beverage production scenes.

The invention discloses bioactive macroporous hydrogel as well as a preparation method and application thereof. The bioactive macroporous hydrogel comprises hydrogel particles and a bioactive load loaded on the hydrogel particles, the hydrogel particles are obtained by mechanically extruding a hydrogel matrix, and the hydrogel matrix is formed by compounding sodium alginate, agarose and methacrylated hyaluronic acid through hydrogen bond crosslinking and photo-crosslinking; the bioactive load comprises: a) small extracellular vesicles of which the surfaces are modified with macrophage targeted CRV peptides; and b) a PLGA (poly (lactic-co-glycolic acid)) microsphere loaded with a cartilage inducer Kartogenin. The bioactive macroporous hydrogel disclosed by the invention has an internally communicated macroporous network, is beneficial to cell infiltration, blood vessel ingrowth and nutrient substance diffusion, and overcomes the defects that the traditional hydrogel is small in pore size and limits cell behaviors. According to the bioactive macroporous hydrogel disclosed by the invention, dual bioactive loads are adopted to synergistically promote tendon-bone healing, so that the treatment effect is better.

The invention discloses a full-automatic chemiluminiscence detection reagent for a porcine reproductive and respiratory syndrome virus N antibody and application of the full-automatic chemiluminiscence detection reagent, and belongs to the technical field of biology. The detection reagent comprises a serum diluent, a first reagent and a second reagent, the first reagent comprises magnetic particles coated with porcine reproductive and respiratory syndrome virus N protein; and the second reagent comprises an acridinium ester labeled anti-pig antibody. The kit can accurately detect the porcine reproductive and respiratory syndrome virus N antibody, is high in sensitivity, good in specificity, strong in interference resistance, high in precision, short in reaction time, simple to operate and automatic, provides material guarantee and technical support for prevention and control of porcine reproductive and respiratory syndrome, and has important significance.

A method for removing particles from water, the method comprising: supplying gelatinous zooplankton mucus to water comprising particles; allowing formation of particle aggregates in the water by allowing interaction between the particles in the water and the gelatinous zooplankton mucus; removing the particle aggregates from the water by passing the water comprising particle aggregates through a filter configured to receive water comprising particle aggregates and further filter the water; and exiting filtered water from the filter. A system for removing particles from water with the aforementioned method is also provided. Additional embodiments of the system and method for removing particles from water are disclosed herein.

The invention belongs to the technical field of multifunctional composite seed coatings for ecological restoration of high and cold regions, discloses a Qinghai cold-region bluegrass seed coating agent and a preparation method thereof, and aims to solve the composite problems of component antagonism, time sequence mismatch, freeze-thaw failure and the like in the prior art. The coating agent is characterized in that a three-layer composite structure of a biological core layer, a nutrition buffer layer and a functional protection layer is sequentially coated on the surface of a seed from inside to outside. The biological core layer comprises complex microbial inoculant particles and a first adhesive; the nutrition buffer layer comprises a low-temperature germination inducer, a slow-release nutrition microcapsule and a second adhesive; the functional protection layer comprises an interpenetrating network polymer skeleton, high molecular weight sodium alginate, nano silicon dioxide particles subjected to surface modification by a silane coupling agent KH-570 and food-grade indigo dye. By means of the scheme, efficient germination and stable planting of the Qinghai cold land bluegrass seeds in the high and cold environment are achieved.

The invention discloses a water glass-based full-life super-amphiphobic radiation refrigeration block material, which is prepared from the following raw materials in parts by weight: 1.5 to 3 parts of C-F long-chain modified micro-nano particles, 0.5 to 1.5 parts of water glass-based binder, 0.1 to 0.3 part of nano silicon dioxide sol and 0.05 to 0.16 part of curing catalyst, the C-F long-chain modified micro-nano particles are obtained by sequentially carrying out silane coupling agent grafting modification and fluorosilane grafting modification on nano particles with high sunlight reflectivity and micro particles with high sunlight emissivity. The super-amphiphobic function is converted into a three-dimensional block material from a two-dimensional coating, stress distribution optimization and interface bonding energy improvement are achieved while the ultra-low surface energy characteristic is kept, the problems of optical performance degradation and the like caused by surface pollution of the radiation refrigeration material are effectively solved, the mechanical durability of the material is essentially improved, and the service life of the radiation refrigeration material is prolonged. And the radiation refrigeration system can maintain stable performance in the whole life cycle.

Provided is a composition for controlling uptake of microparticles into a body, the composition containing a lactic acid bacterium. The lactic acid bacterium is preferably any one selected from bacteria belonging to the genus Lactobacillus and bacteria belonging to the genus Streptococcus. For example, the lactic acid bacterium is a bacterium belonging to Lactobacillus delbrueckii, Lactobacillus paracasei, Lactobacillus gasseri, or Streptococcus thermophilus.

The invention discloses an electromagnetic shielding cable for a radio altimeter and a preparation method thereof, and relates to the technical field of cables. The preparation method comprises the following steps: treating ethylene-tetrafluoroethylene copolymer particles, a mixed compatilizer, a chemical foaming agent and a nano nucleating agent by using mixed gas low-temperature plasma containing acrylic acid, performing melt blending by using a double-screw extruder, injecting supercritical carbon dioxide, and performing slow cooling and shock cooling to obtain a three-dimensional porous matrix containing micro-nano cells; the preparation method comprises the following steps: synthesizing ferroferric oxide particles by a solvothermal method, coating a silicon dioxide dielectric layer, and then chemically silvering to prepare ternary core-shell composite particles; modifying the particles with aminopropyltriethoxysilane and a block copolymer to obtain modified composite particles; melting, mixing and granulating the porous matrix and the modified composite particles to obtain the electromagnetic shielding composite material. And performing extrusion molding on a conductor to form an insulation shielding layer, thereby obtaining the cable. The cable has an excellent electromagnetic shielding effect.

According to the Tesla valve structure-imitated micro-flow controller and the preparation method thereof, improvement design is carried out on the basis of an existing Tesla valve structure, the pipe wall of a first branch straight pipe section is designed to be of an arc-shaped structure, the area is increased by 20%-30%, a sawtooth-shaped structure is arranged on the pipe wall, a tiny cavity is additionally formed in a second branch straight pipe section, and the area of the first branch straight pipe section is increased by 20%-30%; the diameter of the structure of the shunting section is modified to be gradually increased, so that the cross sectional area of the shunting section is expanded by 25%-30%, the inner diameter of the branch annular section is reduced, the outer diameter of the branch annular section is expanded, the area of the expanded branch annular section is increased by 25%-35%, and the length of the outlet section is prolonged to be 30%-40% of the original length. The micro-flow controller with the imitated Tesla valve structure prepared by the invention can effectively guide fluid to flow, reduce accumulation of micro-particles in a micro-channel and enhance the impurity particle embolism resistance of a system, so that the stability and reliability of the whole system are improved.

The invention provides a water-based suspension pesticide composition. The water-based suspension pesticide composition comprises the following components: a solvent deionized water; based on the mass of the solvent, the core-shell structure active particles account for 0.5-20w%; based on the mass of the solvent, 0.01-5w% of a suspension stabilizer; the core-shell structure active particles are humidity response microspheres resistant to acid and alkali, the core-shell structure active particles are used, intermolecular acting force is reduced, particle agglomeration is reduced, dispersity of active ingredients is improved, a natural polymer material is adopted as a shell, biocompatibility is good, biodegradability is achieved, pollution to the environment is reduced, and the core-shell structure active particles are environmentally friendly. Meanwhile, the PEG-PCL block copolymer is introduced, so that the pesticide release rate can be accurately controlled according to the environment humidity change, and the pesticide utilization rate is increased. Moreover, the chitosan-sodium alginate composite gel of the particle shell layer is stably and slowly released in neutral and weakly alkaline soil, in acidic and strongly alkaline environments, the microspheres are prevented from collapsing, the stability of the particle slow-release system in soil with different PH values is improved, and the application range of the active particles is expanded.

The utility model discloses a single particle mechanical property test system, which can realize the whole process of observing and detecting micro particles from being extruded to a crushing state, and comprises a test frame, an objective table, a glass slide, a pressure head, an objective lens, a lower light source, an eyepiece, an imaging device and a refraction single lens, the objective table is mounted on the test frame in an X-Y axis adjustable manner, and is provided with a through hole; the glass slide stretches across the through hole and is used for placing a particle sample to be tested; the pressure head is matched above the objective table in a lifting manner along the Z-axis direction; the objective lens is arranged below the through hole; the lower light source is arranged on the side below the objective lens; the eyepiece is arranged on the surface of the test frame; the imaging device is arranged in the test frame; the refraction single lens is arranged below the objective lens, and the reflection surface of the refraction single lens simultaneously faces the objective lens and the imaging device; the refraction single lens refracts light emitted by the lower light source to the direction of the objective lens, the light in the direction of the objective lens is reflected to the imaging device through the reflection face, and the imaging device presents collected images on the eyepiece.

Disclosed in the present invention are an aqueous triggered controlled-release saline-alkali soil conditioner and a preparation method therefor. The aqueous triggered controlled-release saline-alkali soil conditioner comprises agent A. The agent A comprises a water-soluble polymer and controlled-release suspended particles. The controlled-release suspended particles comprise alginate / anti-reverse regulator composite particulates. The alginate / anti-reverse regulator composite particulates are obtained by sequentially subjecting an alginate to two-step gel cross-linking by means of a cationic anti-reverse regulator and a high-valent metal ion-containing cross-linking agent. In the present invention, the alginate used as a main material is subjected to charged regulator-based high-speed dispersion for primary gelation and high-valent metal-based secondary gelation, thereby preparing a micron-nano powder and suspension, and incorporating a solvable organic polymer material, the functions of graded release and intelligent regulation of a product are achieved. The incorporation of an organic acid and a phosphoric acid material can not only prevent a micro-irrigation device from scaling but can also achieve triggered controlled-release of the material on demand and in a timely manner, thereby achieving the effects of multi-particle-size dispersion and precise release of the product in soil.

The invention relates to the technical field of water treatment, in particular to a method for treating degradation-resistant organic pollution underground water based on a micro-interface strengthening technology. According to the technical scheme, the method comprises the steps that an underground water sample is collected and subjected to pollution characteristic analysis, composite material slurry is injected into a water-containing layer to construct an interface-enhanced in-situ reaction system, and the slurry is composed of nanoscale iron-based metal particles, graphene oxide derivatives, modified biochar, a surfactant and the like; meanwhile, a low-pressure gas injection system is arranged to form a micro-aerobic environment so as to improve the interface reaction efficiency, dominant microbial communities are synchronously injected, a slow-release carbon source carrier is added so as to strengthen the biological synergistic degradation effect, and the operation state of the system is regulated and controlled through multi-parameter monitoring. According to the method, a micro-interface synergistic system integrating physical adsorption, chemical reduction and biological metabolism is constructed, refractory organic pollutants such as aryl halide and polycyclic aromatic hydrocarbon in underground water can be efficiently and stably removed, and the method has the advantages of being high in remediation efficiency, high in operation stability and wide in environmental adaptability.

The invention discloses a preparation method of a silicon-titanium composite particle with a raspberry-shaped structure, which comprises the following steps: compounding nano-scale silicon dioxide and titanium dioxide according to a certain ratio, and carrying out spray granulation to obtain the silicon-titanium composite particle. After light rays are incident, the light rays are subjected to multiple scattering due to aggregation and stacking of the microparticles, and the particles with the raspberry-shaped structures have a soft focus effect due to reflection and transmission of the surfaces and the internal particles of the particles. The high-refractive-index titanium dioxide uniformly distributed in the particles can improve the light diffusion effect and improve the sunscreen performance of the particles at the same time. The method has the characteristics of simplicity and convenience in operation, easiness in obtaining raw materials, high biocompatibility and the like, and has a wide application prospect in the field of cosmetics.

Provided herein is a coated particle comprising: (i) a microparticle that comprises a pharmaceutically acceptable excipient and (ii) nanoparticles of a therapeutic agent, wherein the surface of the microparticle is coated with the nanoparticles. Also provided herein is a pharmaceutical composition comprising the coated particle. Furthermore, provided herein are methods of their preparation.

The application provides a low-crystallinity hydroxyapatite microsphere for implantation and a preparation method thereof, and the preparation method comprises the following steps: preparing a mixed solution of a calcium source reagent and a phosphorus source reagent, adding inorganic acid, alkali and a buffer into the mixed solution, adding a surfactant, and obtaining a hydroxyapatite micro-particle precipitate through constant-temperature reaction; cleaning the hydroxyapatite micro-particle precipitate, and preparing a hydroxyapatite micro-particle suspension by adding water; and performing spray drying on the hydroxyapatite micro-particle suspension to obtain the hydroxyapatite microsphere; wherein the surfactant is one or more of PEG and PVP. The hydroxyapatite microsphere obtained by the application has stable structure, belongs to spherical large particles, is easy to inject, and is not prone to agglomeration; when the hydroxyapatite microsphere is injected into a human body, the hydroxyapatite microsphere has good supporting effect; and the preparation method of the application is simple, has few process steps, and is easy to realize reaction conditions, and is suitable for large-scale production.

The invention relates to the technical field of food safety detection, in particular to solid-phase extraction filler for detecting pesticide residues in food and a preparation method and application thereof.The solid-phase extraction filler comprises a magnetic filler core and a selective adsorption layer wrapping the magnetic filler core; wherein the interior of the magnetic filler core at least comprises magnetic particles and a coating layer for improving the stability of the magnetic particles; the selective adsorption layer is composed of a porous organic framework material which is chemically grafted outside the coating layer; and a temperature-sensitive polymer gel layer also covers the outer part of the selective adsorption layer. According to the solid-phase extraction filler disclosed by the invention, through an innovative hierarchical structure design, the extraction of trace pesticide residues in food can be effectively improved, the extraction difficulty is reduced, and the extraction efficiency and the extraction selectivity are improved.

The invention belongs to the field of biomedical materials and tissue engineering, and particularly relates to an injectable mineralized collagen bone repair composite material loaded with stem cell recruitment factors and osteogenic induction factors and a preparation method of the injectable mineralized collagen bone repair composite material. The composite material is composed of 50%-53% of mineralized collagen matrix particles, 15%-20% of SDF-1alpha loaded heparinized gelatin microspheres, 15%-20% of BMP-2 loaded PDA coated mesoporous silica particles, 8%-10% of an NHS-PEG-NHS cross-linking agent and 4%-6% of glycerin. The composite material can realize time-space sequential regulation and control of'collection first and then differentiation '; a bionic bone matrix microenvironment is provided through the mineralized collagen matrix; the problems of two-factor release conflict and stability are solved; in-vitro experiments show that the material can significantly promote stem cell migration and osteogenic differentiation, and animal experiments prove that the material can recover 82-88% of mechanical properties of bone defect parts. The invention solves the technical problems of insufficient stem cell collection, low osteogenic differentiation efficiency and uncontrollable factor release of the existing bone repair material.

The utility model provides a trapping device for enhancing the trapping efficiency of geogas nano-metal particles, which relates to the technical field of geochemical measurement and comprises a trapping cylinder, a trapping pipe and a dispersion filter disc, the trapping barrel is filled with trapping liquid, an extraction opening is formed in the top of the trapping barrel, the gas inlet end of the trapping pipe is located outside the trapping barrel, and the gas outlet end of the trapping pipe extends into the trapping pipe. The trapping device has the beneficial effects that the gas in the stratum can be continuously pumped into the trapping barrel through the trapping pipe by pumping the gas from the gas pumping opening of the trapping device, so that the trapping liquid can trap nano metal particles in the gas in the stratum. The bubbler is arranged downwards, so that the migration path of the gas to be washed in the trapping liquid can be prolonged; the bubbler at the gas outlet end of the trapping pipe and the dispersing filter disc above the bubbler can disperse the gas overflowing from the gas outlet end of the trapping pipe into tiny bubbles, the contact area of the gas to be washed and the trapping liquid is increased, and therefore the trapping efficiency of the nano metal particles in the gas in the stratum is effectively improved.

The invention discloses a preparation method of a tomato culture medium, which aims at solving the technical problems that peat resources are non-renewable and high in cost and the utilization rate of mulberry twig wastes is low, and is realized by the following technical scheme: firstly, crushing fresh mulberry twigs into particles; mixing silkworm excrement with a sodium alginate solution, and coating the mulberry twig particles in a fluidized bed at the air temperature of 60 DEG C and the atomization pressure of 0.3 MPa to form core-shell structure particles with the shell thickness of 0.1-0.3 mm; then mixing the core-shell particles with fine peat to form a mixture, and stacking the mixture with the coarse peat and the fine peat to form a three-layer gradient structure; and finally, spraying a zymophyte liquid with trichoderma content greater than or equal to 1.0 * 10 < 7 > CFU / mL until the water content is 40%, and standing and activating for 20 days. The matrix takes mulberry twigs as a core raw material, combines silkworm excrement slow-release fertilizer efficiency and gradient structure optimization water-air balance, can replace a traditional peat matrix to be used for tomato planting, and realizes agricultural waste recycling and low cultivation cost.

The utility model provides a sampling device for detecting the number of particles in purification equipment, and relates to the technical field of medical environment detection, and a sampling head is used for collecting the number of particles in the purification equipment; the sampling pipe can be bent at any angle and reach different depths for directional positioning, and the lower part of the sampling pipe is provided with a circuit and gas circuit joint which can be connected with a handle or a lengthened pipe; the upper part of the handle is provided with a display device and the lower part of the handle is a handheld part; the detection equipment is used for detecting the number of particles in air in the purification equipment, and a detection result is displayed through a display screen on the detection equipment and a display device on a handle; the lighting device and the camera device are arranged on the sampling tube and can also be bent by any angle and reach different depths for directional positioning; the lighting device is used for lighting the internal environment of the purification equipment, and the camera shooting device is used for observing and shooting the internal environment in real time; and when a person cannot enter the purification equipment, the detection operation can still be normally carried out.

The utility model discloses a calcium hydroxide particle size accurate regulation and control device which comprises a workbench and a particle size regulation and control assembly used for accurately regulating and controlling the particle size of calcium hydroxide particles, a collecting hole is formed in one end of the upper surface of the workbench, and a fixing cylinder is fixedly installed at one end of the edge of the upper surface of the collecting hole. The particle size regulation and control assembly is detachably installed on one side of the fixing cylinder, an installation rod is fixedly installed at the other end of the upper surface of the workbench, an empty groove is formed in one side of the workbench, a vibration motor is arranged in the empty groove, and a linkage cylinder is fixedly installed at one end of the outer surface of the fixing cylinder. The whole structure has high regulation and control capacity on calcium hydroxide particles, accurate regulation and control can be carried out, the condition of mixing caused by large particle size span is avoided, particle size distribution is uniform, and application scenes with high particle size uniformity requirements can be effectively met.

To provide a new method, model, program or the like for acquiring information usable for a disease diagnosis or prognosis prediction by using a sample taken from lungs or exhaled breath.SOLUTION: A method for assisting disease diagnosis or prognosis prediction including: acquiring (A) extracellular particle information on a population of extracellular particles collected from lungs or exhaled breath of a subject; the extracellular particle information including scattered light information on scattered light of irradiated light about each extracellular particle of the population of extracellular particles, and light emission information on a plurality of light emission whose peak wavelengths are mutually different, caused from a component of the extracellular particles or a labelling substance connected to the component due to the irradiated light; and (B) disease information on a state of a disease in the subject from each subject included in a group of subjects; and acquiring information for assisting the disease diagnosis or the prognosis prediction related to the extracellular particles collected from the lungs or the exhaled breath by machine learning on the basis of a data set including the extracellular particle information and the disease information.SELECTED DRAWING: Figure 1

Encoded separation pool libraries are provided herein, which are useful, inter alia, in forming highly diverse and dense arrays for screening and detecting a variety of molecules. A method of immobilizing a microparticle on a solid support is disclosed, wherein the microparticle is covalently linked via first and second linkers to a linker domain (e.g., peptide, protein, small molecule) and a nucleic acid, and performing a decoding process on the nucleic acid domain, thereby determining the composition of the linker domain and its location on said solid support. The second linker is selectively cleavable provided that the first linker is not cleavable. The decoding may include hybridization or sequencing. The second linker is e.g. a photocleavable linker or includes -S(O)2NH- -NHS(O)2- -C(O)O-, -OC(O)-, -C(O)NH-, -NHC(O)-.The linker domain may be bound to a linker ligand (which may be fluorescent), unless protected by a protecting group, which may be removed.

The invention discloses polysiloxane particles and a preparation method thereof. The polysiloxane particles comprise polysiloxane particles with a main chain as a T unit and Q units in the polysiloxane particles; wherein the T unit is R1SiO3 / 2, and R1 is alkyl with 1 to 18 carbon atoms; and the Q unit is SiO4 / 2. According to the polysiloxane particle disclosed by the invention, a Q unit is introduced into polysiloxane with a lower dielectric constant and a T unit as a main chain, so that the polysiloxane particle with a low dielectric constant and a low thermal expansion coefficient is obtained; meanwhile, the polysiloxane particles are filled with Q units, so that the water absorption capacity of the polysiloxane particles is obviously reduced, and the dielectric loss is further reduced.

The present disclosure provides a composition for modifying the surface of mitochondria, comprising: a polymer backbone; a first chemical moiety conjugated to the polymer backbone, the chemical moiety comprising a peptide; and a second chemical moiety conjugated to the polymer backbone, the second chemical moiety comprising triphenylphosphine. The disclosure also provides a hydrogel comprising a plurality of hydrogel particles, each particle comprising a first polymer crosslinked with an enzyme cleavable peptide to form a crosslinked polymer and at least one mitochondria, wherein each hydrogel particle has an average diameter no greater than 100 microns. Methods of treating a disease and / or injury in a subject by administering the hydrogel are also provided.