207 results about "Micro particles" patented technology

The invention discloses a method for constructing a multicellular living body material by adopting a droplet bioreactor, which belongs to the crossing field of biological materials and microbial engineering, and comprises the following steps: (1) resuspending different cells in different polymer solutions to prepare degradable or phase-separable hydrogel particles containing cells; (2) dispersing the hydrogel particles in a cross-linkable hydrogel matrix to form a composite hydrogel; and (3) curing the composite hydrogel, and then carrying out degradation treatment to obtain the liquid cavity structure multicellular system bioreactor with spatial partition and dynamic interaction characteristics. According to the invention, ordered distribution and metabolism synergy of different microorganisms in space can be realized, controllable degradability and excellent mass transfer performance are realized, bacterial slow release and metabolite exchange can be maintained, and the method is suitable for long-term stable operation of a continuous flow reactor. The method has wide application prospects in the fields of green biological manufacturing, renewable energy source production, environmental restoration, biomedical engineering and the like.

The invention belongs to the technical field of biomedical tissue engineering materials, and particularly relates to injectable composite plastic gel and a preparation method thereof. The injectable plastic gel provided by the invention is formed by suspending and compounding the cross-linked sodium hyaluronate gel particles and the biological tissue extracellular matrix particles, the two material particles in the injectable composite plastic gel are uniform in size and controllable in size, other toxic catalysts do not need to be added in the preparation process, and the injectable plastic gel is easy to prepare. The collagen / elastin composite material is rich in collagen and elastin, and shows good biomechanical properties. Meanwhile, the composite plastic gel contains a plurality of bioactive factors, and after the composite plastic gel is injected and filled into a body, the composite plastic gel is slowly degraded and can promote the generation and ingrowth of autologous fat cells and microvessels, so that the balance of degradation and remodeling is achieved. The preparation method of the injectable plastic gel provided by the invention can be widely applied to the fields of plastic surgery, medical beauty and the like.

The invention belongs to the technical field of multifunctional composite seed coatings for ecological restoration of high and cold regions, discloses a Qinghai cold-region bluegrass seed coating agent and a preparation method thereof, and aims to solve the composite problems of component antagonism, time sequence mismatch, freeze-thaw failure and the like in the prior art. The coating agent is characterized in that a three-layer composite structure of a biological core layer, a nutrition buffer layer and a functional protection layer is sequentially coated on the surface of a seed from inside to outside. The biological core layer comprises complex microbial inoculant particles and a first adhesive; the nutrition buffer layer comprises a low-temperature germination inducer, a slow-release nutrition microcapsule and a second adhesive; the functional protection layer comprises an interpenetrating network polymer skeleton, high molecular weight sodium alginate, nano silicon dioxide particles subjected to surface modification by a silane coupling agent KH-570 and food-grade indigo dye. By means of the scheme, efficient germination and stable planting of the Qinghai cold land bluegrass seeds in the high and cold environment are achieved.

According to the Tesla valve structure-imitated micro-flow controller and the preparation method thereof, improvement design is carried out on the basis of an existing Tesla valve structure, the pipe wall of a first branch straight pipe section is designed to be of an arc-shaped structure, the area is increased by 20%-30%, a sawtooth-shaped structure is arranged on the pipe wall, a tiny cavity is additionally formed in a second branch straight pipe section, and the area of the first branch straight pipe section is increased by 20%-30%; the diameter of the structure of the shunting section is modified to be gradually increased, so that the cross sectional area of the shunting section is expanded by 25%-30%, the inner diameter of the branch annular section is reduced, the outer diameter of the branch annular section is expanded, the area of the expanded branch annular section is increased by 25%-35%, and the length of the outlet section is prolonged to be 30%-40% of the original length. The micro-flow controller with the imitated Tesla valve structure prepared by the invention can effectively guide fluid to flow, reduce accumulation of micro-particles in a micro-channel and enhance the impurity particle embolism resistance of a system, so that the stability and reliability of the whole system are improved.

Disclosed in the present invention are an aqueous triggered controlled-release saline-alkali soil conditioner and a preparation method therefor. The aqueous triggered controlled-release saline-alkali soil conditioner comprises agent A. The agent A comprises a water-soluble polymer and controlled-release suspended particles. The controlled-release suspended particles comprise alginate / anti-reverse regulator composite particulates. The alginate / anti-reverse regulator composite particulates are obtained by sequentially subjecting an alginate to two-step gel cross-linking by means of a cationic anti-reverse regulator and a high-valent metal ion-containing cross-linking agent. In the present invention, the alginate used as a main material is subjected to charged regulator-based high-speed dispersion for primary gelation and high-valent metal-based secondary gelation, thereby preparing a micron-nano powder and suspension, and incorporating a solvable organic polymer material, the functions of graded release and intelligent regulation of a product are achieved. The incorporation of an organic acid and a phosphoric acid material can not only prevent a micro-irrigation device from scaling but can also achieve triggered controlled-release of the material on demand and in a timely manner, thereby achieving the effects of multi-particle-size dispersion and precise release of the product in soil.

The invention relates to the technical field of food safety detection, in particular to solid-phase extraction filler for detecting pesticide residues in food and a preparation method and application thereof.The solid-phase extraction filler comprises a magnetic filler core and a selective adsorption layer wrapping the magnetic filler core; wherein the interior of the magnetic filler core at least comprises magnetic particles and a coating layer for improving the stability of the magnetic particles; the selective adsorption layer is composed of a porous organic framework material which is chemically grafted outside the coating layer; and a temperature-sensitive polymer gel layer also covers the outer part of the selective adsorption layer. According to the solid-phase extraction filler disclosed by the invention, through an innovative hierarchical structure design, the extraction of trace pesticide residues in food can be effectively improved, the extraction difficulty is reduced, and the extraction efficiency and the extraction selectivity are improved.

The utility model discloses a calcium hydroxide particle size accurate regulation and control device which comprises a workbench and a particle size regulation and control assembly used for accurately regulating and controlling the particle size of calcium hydroxide particles, a collecting hole is formed in one end of the upper surface of the workbench, and a fixing cylinder is fixedly installed at one end of the edge of the upper surface of the collecting hole. The particle size regulation and control assembly is detachably installed on one side of the fixing cylinder, an installation rod is fixedly installed at the other end of the upper surface of the workbench, an empty groove is formed in one side of the workbench, a vibration motor is arranged in the empty groove, and a linkage cylinder is fixedly installed at one end of the outer surface of the fixing cylinder. The whole structure has high regulation and control capacity on calcium hydroxide particles, accurate regulation and control can be carried out, the condition of mixing caused by large particle size span is avoided, particle size distribution is uniform, and application scenes with high particle size uniformity requirements can be effectively met.

Encoded separation pool libraries are provided herein, which are useful, inter alia, in forming highly diverse and dense arrays for screening and detecting a variety of molecules. A method of immobilizing a microparticle on a solid support is disclosed, wherein the microparticle is covalently linked via first and second linkers to a linker domain (e.g., peptide, protein, small molecule) and a nucleic acid, and performing a decoding process on the nucleic acid domain, thereby determining the composition of the linker domain and its location on said solid support. The second linker is selectively cleavable provided that the first linker is not cleavable. The decoding may include hybridization or sequencing. The second linker is e.g. a photocleavable linker or includes -S(O)2NH- -NHS(O)2- -C(O)O-, -OC(O)-, -C(O)NH-, -NHC(O)-.The linker domain may be bound to a linker ligand (which may be fluorescent), unless protected by a protecting group, which may be removed.

The present disclosure provides a composition for modifying the surface of mitochondria, comprising: a polymer backbone; a first chemical moiety conjugated to the polymer backbone, the chemical moiety comprising a peptide; and a second chemical moiety conjugated to the polymer backbone, the second chemical moiety comprising triphenylphosphine. The disclosure also provides a hydrogel comprising a plurality of hydrogel particles, each particle comprising a first polymer crosslinked with an enzyme cleavable peptide to form a crosslinked polymer and at least one mitochondria, wherein each hydrogel particle has an average diameter no greater than 100 microns. Methods of treating a disease and / or injury in a subject by administering the hydrogel are also provided.

Described herein are systems and methods to manipulate magnetic particles in liquid suspension. The system comprises at least two magnets, wherein one magnet tip is enclosed in a non-magnetic capsule that can be immersed into and pulled out of the liquid suspension contained in a vessel, and another magnet located outside of the vessel that may be activated to repel the magnet tip enclosed in the capsule. Microparticles in the liquid suspension are driven to the bottom of the vessel when the external magnet is activated and otherwise are driven to the bottom surface of the non-magnetic capsule by the magnet tip. Among other applications, the invention can be used in biotechnology to separate magnetic particles from a liquid suspension in a vessel as well as to transfer magnetic particles among a variety of liquid suspensions in multiple vessels

The present disclosure relates generally to microparticles containing algal proteins and their use in various applications. In some embodiments, the microparticles are precipitates. In some other embodiments, the microparticles are coacervates. In some embodiments, the microparticles are core-shell microcapsules having a hydrophobic core material encapsulated by a shell that contains an algal protein. In some embodiments, the hydrophobic core material comprises a flavor oil, a fragrance oil, or a combination thereof. In certain aspects, the disclosure provides the use of such microparticles to improve the texture, mouthfeel, perceived fattiness, or perceived creaminess of a comestible article. In some embodiments, the comestible article is a vegan dairy product, a vegan meat product, or a vegan seafood product. In certain aspects, the disclosure provides the use of the microparticles to provide a fragrance to a fragranced product, such as a personal care product, a laundry product, or a cosmetic product.

The invention provides a preparation method of core-shell coated piezoelectric electro-catalytic composite abrasive particles, which comprises the following steps: (1) synthesizing uniform piezoelectric material nano-particles by using two solvents with different polarities and adopting a phase separation induced nano-precipitation method; (2) putting the piezoelectric material nanoparticles into a sodium hydroxide deionized water solution, heating in a water bath at 80 DEG C, and carrying out surface modification on the surfaces of the nanoparticles; and (3) the piezoelectric material nano-particles subjected to surface modification react with cerium salt and a precipitator, and finally the composite abrasive particles are obtained. According to the method, the piezoelectric material is pretreated and modified, the modified piezoelectric material reacts with the photocatalytic material and the precipitator, the core-shell coated piezoelectric electro-catalytic composite abrasive particle is successfully prepared, the composite abrasive particle has good catalytic oxidation capacity, when the composite abrasive particle is used for polishing a GaN wafer, the removal efficiency of the material can reach 480 nm / h, and the removal rate of the material can reach 480 nm / h. And the abrasive particles are far higher than cerium oxide-based abrasive particles.

A mixture for enhancing eye lubrication comprises a plurality of microspheres having diameters ranging from about 5-40 microns combined with an aqueous component comprising water. The microspheres can be coated with oil. When the mixture is applied to the surface of a user's eyes, the microparticles will enhance lubrication during blinking and partially lift eyelids so that other components of the mixture can be better distributed beneath the eyelids. An oil can be added to the mixture. Preferably the oil is configured so that, when the mixture is agitated, it forms a temporary, thermodynamically unstable emulsion from which the oil quickly disassociates when the mixture is applied to the eye. The oil thus is quickly available to enhance lubrication performance.

A kind of microplastic toxicity exposure risk evaluation method for fish with wild grass carp as sample, the present application relates to the field of microplastic toxicity exposure risk evaluation, specifically relates to a kind of microplastic toxicity exposure risk evaluation method for fish with wild grass carp as sample.The present application is to solve the problem that the existing evaluation method is single, cannot comprehensively and accurately evaluate the toxicity exposure risk of microplastic to fish.Method: I, set experimental group;II, input wild grass carp to experimental group, record body length and weight;III, feed cultivation, respectively add corresponding microplastic particles, the control group does not add microplastic particles;IV, combine the weight change of wild grass carp, body length change, feeding rate, mortality and intestinal microbial diversity index for calculation;The higher the value of comprehensive index R, the higher the toxicity risk of microplastic to fish is evaluated.The present application is used to evaluate the toxicity exposure risk of microplastic to fish with wild grass carp as sample.

The invention relates to a large-particle dog and cat oral health-care functional food wrapped with instant freeze-dried particles and a preparation method thereof, and belongs to the technical field of pet food. According to the scheme, an external spraying system comprises grain base material particles, 0.1 to 0.15 part of lecithin, 0.002 to 0.003 part of monostearin, 0.001 to 0.003 part of vitamin E and 0.8 to 1.2 parts of chicken oil, and an instant freeze-dried particle layer comprises 0.1 to 0.2 part of fucoidan, 0.02 to 0.05 part of lysozyme, 0.04 to 0.08 part of tea polyphenol, 0.02 to 0.04 part of zinc gluconate, 0.05 to 0.1 part of Arabic gum, 0.03 to 0.1 part of glutamine, 0.01 to 0.02 part of vitamin B2, 0.01 to 0.04 part of vitamin B12 and 0.02 to 0.07 part of glycine. The toothpaste can effectively inhibit the formation of dental plaque and dental calculus and remove halitosis.

The invention provides an acoustic-magnetic dual-mode diagnosis and treatment agent as well as a preparation method and application thereof, and belongs to the technical field of preparation of tumor diagnosis and treatment agents. The acoustic-magnetic dual-mode diagnosis and treatment agent is surface-modified magnetic nanoparticles which contain nano balloon genes and are subjected to Escherichia coli induced expression; the nucleotide sequence of the nano-balloon gene is a sequence shown as NCBI: KC601845.1, escherichia coli in the acoustic-magnetic dual-mode diagnosis and treatment agent as a diagnosis and treatment agent carrier has an active targeting property on a tumor hypoxic region, and bacteria contain a nano-balloon and have an acoustic response characteristic; the escherichia coli surface modified magnetic nanoparticles have a magnetic response characteristic. In acoustic-magnetic dual-mode imaging, firstly, on a real-time ultrasonic contrast monitoring image, a nano air bag expressed in bacteria can generate an enhanced tumor ultrasonic echo signal; secondly, under the action of an external changing magnetic field, the magnetic nanoparticles on the surfaces of the bacteria can generate an enhanced tumor magnetic vibration imaging effect, so that more efficient tumor diagnosis and / or treatment can be realized.

This invention provides a layered structure based on electrostatic filtration of nanoscale particles, relating to the field of electrostatic filtration technology. The layered structure connects an electrostatic adsorption layer and a flexible electrode layer to the two poles of a power supply component, with an insulating layer between the electrostatic adsorption layer and the flexible electrode layer. Combined with the gap-micropore dual-level porous structure and high-density electrostatic micronodes of the electrostatic adsorption layer, voltage focusing technology achieves uniform polarization across the entire electrostatic adsorption layer, eliminating adsorption blind zones and enabling efficient and long-lasting filtration of 0.075-100nm nanoparticles. The mask fabricated using this layered structure balances high-efficiency filtration with long-term wearing comfort, significantly improving the technical contradiction of high efficiency but high resistance in existing masks, making it suitable for prolonged industrial work.

A powder or other composition comprising non-spherical, concave microparticles comprising cross-linked starch or polysaccharides, such as plant polysaccharides, in combination with an alginate. Methods for making this powder and methods of using the powder for hemostasis.

The application discloses a photoelectric tweezers device capable of patterning and controlling micro particles, relates to the technical field of micro particle control, and comprises a patterned light beam generating light path, an ultraviolet sheet-shaped illumination module and a photovoltaic wafer control platform. The patterned light beam generating light path generates a preset pattern light beam, and the preset pattern light beam generates a first electric field on the photovoltaic wafer control platform. The ultraviolet sheet-shaped illumination module generates a second laser, and the second laser is expanded, and the intensity and diameter of the expanded second laser are controlled, so that a second electric field is generated on the photovoltaic wafer control platform. Micro particles in the photovoltaic wafer control platform move to a preset pattern area under the influence of the first electric field and the second electric field. The application captures micro particles by using patterned laser, so that the number of controlled particles is increased and the capturing efficiency is improved.

The utility model discloses a kind of mixing transmission device and bioreactor, mixing transmission device includes magnetic transmission structure, transmission sealing structure and mixing structure;The transmission sealing structure is installed on flexible bag, the magnetic transmission structure is set to the outside of the flexible bag, the mixing structure is arranged in the flexible bag;Among them, the lower end of the mixing structure is suspended and arranged, the upper end of the mixing structure is connected to the magnetic transmission structure by the transmission sealing structure, the magnetic transmission structure is connected with external power source, the power source is rotated by the magnetic transmission structure and drives the mixing structure. The utility model aims at overcoming the defects of the prior art and provides a kind of mixing transmission device, which avoids the pollution of insoluble particles generated by the device while ensuring the mixing effect.

1. Name of the product in this design: Flow Cytometer. 2. Purpose of this design: For rapid quantitative analysis and sorting of cells or other biological particles in liquids using multiple parameters. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

Compositions are provided for hydrocarbon applications. In some embodiments, the composition comprises lignin, in particular technical lignin, comprising at least one of lignin nanoparticles and lignin microparticles, preferably wherein at least 20% of the lignin particles are nanoparticles, and at least one strain of bacteria capable of biosurfactant production and / or a biosurfactant produced by at least one such isolated strain of bacteria. Also provided is a related method for making the composition.

The utility model provides a plasma machine metal particle adsorption control device, and belongs to the technical field of adsorption control devices. Comprising an operation box, rotating wheels rotationally installed at the bottom of the operation box, heat dissipation holes formed in the side surface of the operation box, an air inlet formed in the end of the operation box, a connecting shell fixedly connected to the side wall of the operation box, an operation panel fixedly installed on the surface of the connecting shell and a processing assembly fixedly installed in an inner cavity of the operation box. The metal particle capturing efficiency is remarkably improved through the detachable treatment barrel and the multi-stage adsorption structure, the adsorption effect on micron-sized particles is better, meanwhile, the airflow path design is optimized, efficient filtering is achieved through communication of the transmission pump and the air outlet in cooperation with the metal adsorption layer, it is ensured that airflow is evenly distributed, local overheating is avoided, and the service life of the air purifier is prolonged. In addition, the combined structure of the baffle and the limiting plate enables the installation and replacement of the treatment barrel to be more convenient, and the maintenance cost and the time cost are greatly reduced.

The present invention provides a pharmaceutical composition for treating arthropathy, the pharmaceutical composition comprising a composition containing extracellular vesicles derived from a culture supernatant of mesenchymal stem cells, the pharmaceutical composition being characterized in that the culture medium for the mesenchymal stem cells satisfies the following conditions: (1) the culture medium is a culture medium having defined components; the composition does not contain animal-derived components of species different from those of a treated object; and (2) the number of fine particles having a particle diameter of 1-1000 nm is less than 1 * 109 particles / mL in a state prior to use.

The invention relates to the technical field of aerogel microspheres, and discloses hydroxyapatite aerogel microspheres and a preparation method and application thereof.The method comprises the steps that triethyl phosphite and water are subjected to a first contact reaction, and a mixture I is obtained; the mixture I is sequentially mixed with an anionic surfactant, an ethanol solution containing an inorganic calcium source and an alkaline substance for a reaction, and hydroxyapatite aerogel microspheres are obtained; the adding amount of the alkaline substance is controlled, so that the initial pH value of the reaction system is 8-10; the inorganic calcium source is calcium nitrate and / or calcium hydrogen nitrate, and the molar ratio of the calcium element in the inorganic calcium source to the phosphorus element in the triethyl phosphite is 5: (2-4). The hydroxyapatite aerogel spherical particles are prepared by utilizing an emulsion method, and the prepared aerogel microspheres are high in specific surface area, are more regular and uniform, are low in breakage rate and have the advantage of being easier to industrialize.

The invention relates to a magnetic membrane synergetic ultrafiltration system and ultrafiltration method, and the system comprises a magnetic coupling unit and a membrane separation unit; the membrane separation unit comprises a membrane material, and soft magnetic composite particles are embedded in the membrane material; the magnetic coupling unit comprises a first magnetic field device and a second magnetic field device, the first magnetic field device is arranged adjacent to the water inlet end of the membrane separation unit, and the second magnetic field device is arranged adjacent to the backwashing end of the membrane separation unit. The device has the beneficial effects that the membrane material embedded with the soft magnetic composite particles and the magnetic coupling units separately arranged at the water inlet end and the backwashing end have a synergistic effect, so that precise control and efficient cleaning of the membrane pollution process are realized.

The present invention relates to a dispersion comprising acellular dermal matrix microparticles, a filler comprising the same, and uses thereof. More specifically, the present invention relates to a filler comprising a dispersion containing acellular dermal matrix microparticles obtained by supercritical fluid extraction and high pressure dispersion operations, and a method for preparing the same. The acellular dermal filler according to the present invention has excellent biological stability and biocompatibility, and extracellular matrix components such as collagen and elastin are significantly preserved therein. In addition, the filling agent also shows excellent biochemical stability, the pH value or the collagen content and the elastin content are kept unchanged in the storage process, and the filling agent also shows physical stability and can continuously maintain injectability. Therefore, the acellular dermal filler can be effectively used as an injectable filler for repair or volume expansion of soft tissue and reduction of wrinkles in the field of plastic and regenerative medicine.

The invention discloses a particle patterning control device and method based on a multi-mode sound field in a capillary tube. Comprising the steps that particle suspension liquid is injected into a capillary tube, a piezoelectric transducer is arranged on the outer side of the capillary tube, and the piezoelectric transducer is acoustically coupled with the outer surface of the capillary tube; applying an electric signal to the piezoelectric transducer, using the piezoelectric transducer to excite the two-dimensional acoustic resonance mode of the capillary tube, so that a corresponding bulk acoustic wave field is generated in the capillary tube, and the particles in the capillary tube are distributed according to the sound field gradient of the bulk acoustic wave field to form a particle pattern; and manipulating the particle pattern by modulating the excitation frequency or the structure of the capillary. According to the device and the method disclosed by the invention, various complex and stable particle aggregation patterns including circles, ellipses, other high-order modes and the like can be formed in the capillary tube.

The invention discloses a preparation method of a magnetic composite flocculant based on multi-element solid waste recycling and the magnetic composite flocculant obtained by the method. Iron-rich sludge of a sewage treatment plant and fly ash of a coal-fired power plant are used as raw materials; the method comprises the following steps: synthesizing high-purity nanoscale gamma-Fe2O3 magnetic particles A from iron-rich sludge by adopting a process of continuous acid leaching, precise reduction, controllable coprecipitation and mild oxidation; the fly ash is subjected to the processes of ore grinding, activation and vibration fluidization high-gradient magnetic separation, and micron-sized fly ash magnetic bead magnetic particles B are obtained; in a reaction kettle, two kinds of magnetic particles are efficiently compounded with a cationic monomer and a nonionic monomer through an in-situ polymerization technology, the magnetic composite flocculant is prepared, and excellent flocculation efficiency, rapid sedimentation and easy magnetic separation and recovery are achieved. According to the method, green circulation of treating waste with waste is realized, an innovative solution is provided for high-valued utilization of two common solid wastes, and the method has remarkable economic and environmental benefits.

The utility model belongs to the technical field of water treatment, and relates to a drainage water resource utilization system. Comprising drainage water pretreatment equipment, a drainage water filtering device, a first water tank, an ultrafiltration device, a reverse osmosis device and a second water tank which are sequentially connected, suspended matters and part of soluble impurities in the drained water are removed through drained water pretreatment equipment; suspended solids, particulate matters, insoluble impurities and the like in the mine water are further removed through the drainage water filtering device, and it is ensured that the water is clear; impurities such as macromolecular organic matters and colloidal particles in the mine water are removed through the ultrafiltration device; soluble salts and heavy metal ions are removed through the permeation device, so that pure water resources are obtained; according to the device, drainage water is converted into irrigation water and a hydrogen production water source, cyclic utilization of water resources is achieved, waste of the water resources is avoided, and the utilization rate of the water resources is increased.