The invention belongs to the technical field of bulk pharmaceutical chemical preparation and particularly relates to a preparation method of glipizide crystals. According to the technical scheme, the preparation method comprises the first step that glipizide is added into an isopropanol mixed solvent, the solid-to-liquid ratio of the solution is 0.05 g/ml to 0.1 g/ml, and stirring is conducted continuously for 30-60 minutes at the temperature of 40-45 DEG C for dissolution; the second step that dilute alkaline liquor is added, the pH of the solution is regulated to 8-9, and filtering and decoloring are conducted; the filtrate is transferred into a crystallizer, a hydrochloric acid solution is added, the pH of the solution is regulated to 6-7, seed crystals are added and cultured for 1-2 h, then the temperature is dropped to 5-10 DEG C, and the crystals are cultured for 1-3 h; filtering is conducted, a cleaning solvent is used for washing filter cakes, products are dried, and the high-granularity glipizide products are obtained. According to the preparation method of the high-granularity glipizide crystals, the obtained products do not aggregate, the main granularity is 10 microns or above, and granularity distribution is uniform.