The invention discloses pilose antler effervescent tablets and a preparation method thereof, and belongs to the technical field of health-care foods and processing. The main preparation method comprises the following steps: (1) preparing pilose antler powder: selecting a protease enzymolysis assisted ultrasonic extraction method, performing extraction to obtain supernatant, performing spray dryingand performing screening; (2) performing blending according to a formula of the pilose antler effervescent tablets: mixing the pilose antler powder with malic acid, mannitol, sorbitol, maltodextrin,magnesium stearate, sodium bicarbonate and potassium bicarbonate in a certain proportion, performing uniform stirring, and performing tabletting so as to obtain the pilose antler effervescent tablets.The pilose antlers have the functions of promoting growth and development, strengthening bodies, adjusting immunity, resisting inflammation, resisting ageing, promoting wound healing and the like. Compared with ordinary tablets, the effervescent tablets disintegrate in vitro to dissolve out medicines, after the effervescent tablets are taken orally, liquid extensively distributes in gastrointestinal tracts, after about 10-30 min, the liquid is absorbed by stomachs and intestines to enter blood, and local excitation of the medicines in the gastrointestinal tracts is reduced, so that the side effects are reduced, and the effervescent tablets have the characteristics of being quick and efficient to take effect, good in instant properties, easy to absorb and the like.