106results about How to "Reduce local irritation" patented technology

The invention relates to the repair of spinal annular defects. An apparatus comprises a scaffold comprised of a biodurable, resiliently compressible, elastomeric reticulated composition to obliterate spinal / vertabral connective tissue defects, to obliterate spinal-annular nuclear tissue defects, and for spinal annulo-nucleoplasty regeneration. The implant comprises an at least partially cylindrical member.

The present invention relates to a low dose composition of budesonide suitable for administration of budesonide to mucosal membranes for the management of nasal symptoms associated with seasonal allergic rhinitis, perennial allergic rhinitis, perennial non-allergic rhinitis, nasal polyps, as well as prevention of post surgical polyps, chronic sinusitis and recurrent sinusitis comprising budesonide at a therapeutically effective dose of less than 16 mcg and a pharmaceutically acceptable liquid carrier.

The invention discloses a diabecron and glipizide -containing slow-release agent and the method for preparing the same. The glipizide micro-pill takes blank micro-pill as carrier, and combines glipizide and other medical findings with it. The diabecron-containing slow-release micro-pill comprises diabetosan pill, slow-release coating membrane material or other medical findings. The method for preparing diabecron-containing slow-release micro-pill takes extrusion rolling method or blank micro-pill loading method. The product is characterized by safety, high efficient, low toxicity and convenient usage. It can be used to treat non-insulin-dependent diabetes mellitus.

The present invention relates to atomizers for administering preservative-free liquids to the cornea or conjunctiva of the eye, with special eye adapters for atomizers and the use of atomizers for ophthalmological administration. The atomizers according to the invention are free from propellant gas.

The present invention aims to raise water solubility and stability of allicin and allium sativum oil, develop clinically required solid preparation form and liquid preparation form and make use of the treating effect of allicin and allium sativum oil. Cyclodextrin is used to include allicin and allium sativum oil and the clathrate contains allicin oil and cyclodextrin derivative in the molar ratio of 1 to 1-1000 or allium sativum and cyclodextrin derivative in the molar ratio of 1 to 8.6-8600. The cyclodextrin derivative is preferably propyl-beta- cyclodextrin. The clathrate may be used inpreparing injection, powder for injection, infusion fluid, tablet, capsule, microball, etc. and may be developed into various solid and liquid preparation forms for clinical application.

The invention relates to compound tylosin injection for animals and a preparation method thereof. The injection consists of tylosin, doxycycline hydrochloride, trimethoprim, aminophylline, dexamethasone sodium phosphate, organic solvent and injection water. As a dedicated compound preparation for animals, the injection has special effect for treating respiratory tract infection caused by livestock and poultry sensitive bacteria and mycoplasmosis of pigs and poultry. The method has the advantages of convenient use, short course of treatment, low drug resistance and the like.

Disclosed are electrostatically-sprayable topical compositions, more particularly topical emulsion compositions, and methods of treating the skin by electrostatic application of such compositions. In one aspect the composition comprises an insulating external phase comprising one or more insulating materials and a conductive internal phase comprising one or more conductive materials. The compositions preferably also contain one or more particulate materials to be deposited on the skin, e.g., pigments, inert absorbents and the like.

The invention provides an oil adjuvant containing panaxoside and a preparation method thereof. The oil adjuvant is a mixture consisting of panaxoside, adjuvant oil, aluminium stearate and sorbitol mono-oleic acid ester, wherein per milliliter of the oil adjuvant contains 10-100Mug of panaxoside. The preparation method comprises the following steps: heating the oil for preparing the adjuvant to thetemperature of 60-150 DEG C, adding 10-20milligram of aluminium stearate into per milliliter of oil, and mixing evenly; after the temperature of the oil reduces to 50-20 DEG C, adding 5-7% of dehydro-sorbitol mono-oleic acid ester according to volume ratio, stirring evenly, and filtering for standby; and using dimethyl sulfoxide or tween solvent to dissolve the panaxoside into solution; adding 10-100Mug of panaxoside solution into the per milliliter of the prepared standby matter, mixing evenly, and sterilizing for 30min at the temperature of 110 DEG C. Vaccines for immune animals, which is prepared by using oil containing panaxoside as the adjuvant, greatly improve the strength of specificity cells induced by the vaccines and humoral immune response, and reduce local stimulation reactionof injection sites.

The invention discloses a pharmaceutical balloon and a preparation method thereof. The pharmaceutical balloon comprises a balloon, a hydrophilic layer and a drug layer. The hydrophilic layer is formedon the surface of the balloon, and the drug layer is formed on the surface of the hydrophilic layer. The hydrophilic layer comprises a hydrophilic polymer, and the hydrophilic polymer is selected from at least one of polyvinylpyrrolidone, polyacrylamide, polyethylene glycol and polyvinyl alcohol. The drug layer comprises drug microspheres, and each drug microsphere comprises a drug and a degradable polymer covering the drug. The drug carrying layer of the pharmaceutical balloon can release the drugs stably for a long time.

The present invention relates to dry cefadroxil suspension and its preparation process, belongs to the field of medicine technology, and is for raising the water solubility and bioavailability of cefadroxil. The dry cefadroxil suspension consists of cefadroxil and supplementary material comprising including agent, water soluble stuffing, distintegrating agent, suspension assistant and adhesive. The dry cefadroxil suspension has the features of high medicine solubility, high medicine bioavailability, high chemical stability, good taste, convenient taking, high patient's compliance, full absorption in gastrointestinal tract, less irritation to gastrointestinal tract of medicine, etc.

The invention provides a phloroglucinol oral disintegrating tablet, which takes the phloroglucinol as the active ingredient, and disintegrating agents, fillers, lubricants, flavoring agents, binding agents and effervescent agents are added for preparation. The invention further provides a preparation method of the phloroglucinol oral disintegrating tablet. The phloroglucinol oral disintegrating tablet of the invention not only has the rapid disintegration, good taste and no sense of gravel, but can also can be taken under the condition of no water and have the rapid action and more convenient taking, so the invention can improve the compliance of the patients and the efficacy of the drug and other features of the orally disintegrating tablet, at the same time, the invention has light tablet weight, small volume, no powder falling, good brittleness and better dissolution effect than the freeze-dried orally disintegrating tablet. The production cost is low, the dissolution is faster, the invention is more beneficial to the absorption, and the invention can play the effect of pain reliving faster. The invention has the advantage that the invention can carry out the preparation by only adopting the ordinary pressing equipments and the simple technique without the need of special production equipments and conditions.

The invention relates to a compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock and a preparation method thereof. The compound sodium selenite-vitamin E oral nano-emulsion preparation for livestock is prepared from the following raw materials by mass volume percent: 5 to 10% of vitamin E, 15 to 35% of emulsifier, 7.5 to 17.5% of auxiliary emulsifier, 0.1% of sodium selenite, 0.1% of antioxidant and preservative and the balance solvent. The sodium selenite-vitamin E nano-emulsion of the invention is clear and bright emulsion which consists of self-emulsified nano-particles and is a self-emulsified clear and transparent thermodynamically stable system; and the production process is simple and facilitates mass production.

The invention relates to rotundine orally disintegrating tablets and a prescription and process for preparing the rotundine orally disintegrating tablets by adopting a freeze drying method. The rotundine orally disintegrating tablets are prepared from rotundine as a main medicine and pharmaceutic adjuvants, can be taken without water, are capable of rapidly disintegrating after entering the mouth, are suitable for taking by patients suffered from dysphagia, such as the old, children and the like, are simultaneously suitable for medications in the travel journey under the condition of being not easy to obtain a water source, has the advantages of convenience for taking, high absorption speed, small fast pass effect, little irritation to digestive tract mucosa, wide market application prospect and the like, and are capable of remarkably reducing side effects of rotundine. In addition, the invention also relates to a preparation method of the rotundine orally disintegrating tablets.

The invention discloses a preparation method of an enema for chronic renal failure for solving the treatment problem of the chronic renal failure. The preparation method is characterized in that the preparation method comprises the following steps of: (1) performing reduced pressure distillation on ailanthus-like pricklyash bark, catclaw buttercup root and dried mussel coarse powder to extract volatile oil; (2) performing reduced pressure decoction on tall gastrodia tuber to obtain a filtrate; (3) performing water decoction on trikeraia hookeri, magnolia amoena, dragon's blood, melanoidin malt, scorch-fried medicated leaven, mimoselike rosewood leaf, peach gum, cassia twig and dregs obtained in the step (1) to obtain a filtrate for later use; (4) merging the filtrates obtained in the steps (2) and (3), performing reduced pressure concentration to obtain a dry extract, and crushing to obtain dry extract powder; (5) spraying the volatile oil obtained in the step (1) into the dry extract powder obtained in the step (4), uniformly mixing, and screening by a 100-mesh screen to obtain colon dialysis concentrated powder; and (6) adding ten times the volume of warm water into the colon dialysis concentrated powder obtained in the step (5) during the use, and uniformly mixing. Clinical experiments prove that by using the enema for treating the chronic renal failure, the frequency of hemodialysis can be reduced, and the preparation method is further worthy of clinical application and popularization.

The invention discloses a preparation method of a chronic renal failure colon dialysate for solving the treatment problem of chronic renal failure. The preparation method is characterized in that the preparation method comprises the following steps of: (1) performing reduced pressure distillation on ailanthus-like pricklyash bark, catclaw buttercup root and Chinese ephedra root coarse powder to extract volatile oil; (2) performing reduced pressure decoction on tall gastrodia tuber to obtain a filtrate; (3) performing water decoction on trikeraia hookeri, magnolia amoena, dragon's blood, melanoidin malt, scorch-fried medicated leaven, mimoselike rosewood leaf, peach gum, cassia twig and dregs obtained in the step (1) to obtain a filtrate for later use; (4) merging the filtrates obtained in the steps (2) and (3), performing reduced pressure concentration to obtain a dry extract, and crushing to obtain dry extract powder; (5) spraying the volatile oil obtained in the step (1) into the dry extract powder obtained in the step (4), uniformly mixing, and screening by a 100-mesh screen to obtain colon dialysis concentrated powder; and (6) adding ten times the volume of warm water into the colon dialysis concentrated powder obtained in the step (5) during the use, and uniformly mixing. Clinical experiments prove that by using the chronic renal failure colon dialysate for treating the chronic renal failure, the frequency of hemodialysis can be reduced, and the preparation method is further worthy of clinical application and popularization.

The invention belongs to the field of medicine gelatin, and particularly relates to bacterium restraining gelatin and a preparation method thereof. The bacterium restraining gelatin comprises the following raw materials of 0.3-1.0% of carbomer, 0.5-3.0% of glycerine, 0.1-3.0% of propylene glycol, 0.01-1.0% of borneol, 0.1-0.5% of triclosan, 0.1-1.0% of ethanol, 0.01-1.0% of peppermint oil, 0.1-1.0% of an edible bird's nest extract, 0.1-1.0% of a safflower extract, 0.1-1.0% of a ginseng extract, 0.1-1.0% of a herba dendrobii extract, 0.1-1.0% of triethanolamine and the balance pure water. The bacterium restraining gelatin is prepared through a reasonable formula; various bacterium restraining active components are in combined use, so that the bacterium restraining gelatin obtains notable synergistic reactions in the respect of restraining bacteria, and can dispel pathogenic bacteria at affected parts, the pruritic feeling is alleviated and even eliminated, and the resistance capacity and the immune capacity of diseased regions to the pathogenic bacteria can be reinforced.

The invention relates to a veterinary compound enrofloxacin injection and a preparation method thereof. The veterinary compound enrofloxacin injection mainly comprises enrofloxacin, sulfamethoxazole,trimethoprim, flunixin meglumine, tylosin, organic solvent and water for injection. The veterinary compound enrofloxacin injection is used as a veterinary special compound preparation, used for treating various infectious diseases of a respiratory system, a digestive system and a skin soft tissue caused by livestock and poultry bacterial and mycoplasma infection, particularly has special effects on secondary hemophilus disease of pigs and poultries caused by hemophilus and has the advantages of convenient use, short course, low drug resistance and the like.

The invention discloses an anti-dementia medicinal orally disintegrating tablet and a preparation method thereof, and relates to an anti-dementia medicinal orally disintegrating tablet and a prescription and a process for preparing the anti-dementia medicinal orally disintegrating tablet with a freeze-drying method. The anti-dementia medicinal orally disintegrating tablet disclosed by the invention is prepared from a main medicament and medicinal auxiliary materials, can be taken without water, is quickly disintegrated after being put into mouth, and is suitable for patients suffering from dysphagia such as the aged, children and the like; meanwhile, the anti-dementia medicinal orally disintegrating tablet is suitable for taking under the condition that a water source is difficult to obtain during traveling; the anti-dementia medicinal orally disintegrating tablet has the advantages of convenience for taking, quick absorption, small first pass effect, small irritation on digestive canal mucosa and the like, and has a wide market application prospect; and moreover, the anti-dementia medicinal orally disintegrating tablet can be used for remarkably reducing the side effects of an anti-dementia medicament. Moreover, the invention further relates to a preparation method of the anti-dementia medicinal orally disintegrating tablet.

The invention discloses a preparation method of powder for treating atrophic vaginitis, aiming at solving the problem in treating atrophic vaginitis. The preparation method is characterized by comprising the following steps of: (1) carrying out reduced pressure distillation on crude powder of himalayan coralbean bark, ternate buttercup root and ephedra root and extracting volatile oil; (2) carrying out reduced pressure boiling on the volatile oil to obtain a filtrate; (3) boiling Trikeraia hookeri, Magnolia amoena, parasitic loranthus, coked malt, coked medicated leaven, spina gleditsiae, peach gum, cassia twig and the medicinal filtrate obtained in the step (1) so as to obtain a filtrate for later use; (4) combining the filtrates in the steps (2) and (3), carrying out reduced pressure concentration so as to obtain a dry extract, and crushing the dry extract to obtain dry extract powder; (5) ejecting the volatile oil obtained in the step (1) into the dry extract powder obtained in the step (4), uniformly mixing, screening in a sieve of 100 meshes and sub-packaging so as to obtain the powder. Clinical trial shows that the powder has the characteristics of being good in effect on treating atrophic vaginitis and high in security, and is worthy of clinical application and popularization.

The invention provides heparin sodium tube sealing injection, comprising heparin sodium, glucose, mannitol, sodium dihydrogen phosphate, disodium hydrogen phosphate and the balance of water, wherein the tube sealing injection of which the volume is 5ml or 10ml, the osmotic pressure is 260-320 mOsmol / Kg, and the pH value is 6-7 is prepared. By adopting the isotonic injection with low concentration, large volume and stability disclosed by the invention, untoward effects such as local irritation and haemorrhage caused by injection are reduced; the local blood coagulation and tube jamming phenomena are avoided; the anaphylaxis which can be generated by heparin sodium is reduced; meanwhile, the stability of the injection is increased; the sterile level is higher; a plurality of defects in the prior art are solved; and the security of the heparin sodium injection is greatly improved.

The invention discloses an anti-bacteria anti-itch gel and a preparation method thereof. The anti-bacteria anti-itch gel comprises the following raw materials: ethyl alcohol, carbomer, medical glycerol, azone, triclosan, a triclosan solubilizer, water-soluble mint oil, triethanolamine and pure water. The preparation method for the anti-bacteria anti-itch gel comprises the following steps: weighing the components according to the specified weight percentage; preparing a gel substrate: dissolving carbomer into pure water according to proportion to obtain the corresponding gel substrate after the carbomer is completely swelled; adding medical glycerol into the gel substrate, fully stirring, then adding azone, adding ethyl alcohol and water-soluble mint oil, and finally adding triclosan and the triclosan solubilizer so as to preliminarily prepare the anti-bacteria anti-itch gel; finally adding triethanolamine to adjust the pH value of the anti-bacteria anti-itch gel so as to obtain the final anti-bacteria anti-itch gel.

The invention relates to a preparation method for enalapril maleate orally disintegrating tablets. The formula comprises the following ingredients, by weight, enalapril maleate, diluents, disintegrating agents, lubricants and corrective agents with a ratio of 1:(5-6):(3.5-4.5):(0.1-0.3):(0.05-0.15). The diluents, the disintegrating agents, the lubricants and the corrective agents can be substances generally used in pharmaceutical field. Enalapril maleate is crushed by a micropowder machine, and the particle sizes of 90% of the particles are less than 80 microns. Then the diluents, part of the disintegrating agents, the corrective agents are added, mixed uniformly and subjected to dry granulation. Then part of the disintegrating agents, the lubricants are added, mixed totally, and subjected to tabletting, and enalapril maleate orally disintegrating tablets are obtained. The enalapril maleate orally disintegrating tablets are advantaged by rapid disintegration, rapid onset, high absorption and high bioavailability. The enalapril maleate orally disintegrating tablets can reduce irritation effects of medicines on oesophaguses and gastrointestinal tracts and are well suitable for some critical patients to take.

An ophthalmic gel of gatifloxacin and the preparation method thereof are disclosed. The gel comprises gatifloxacin or its pharmaceutical salts, matrix and water. Said matrix is one or more selected from carbomer, mixture of carbomer and HPMC, and sodium hyaluronate.

This invention relates to a method for preparing triptolide / beta-cyclodextrin inclusion compound, which is characterized in preparing according to the follow steps: (1) dissolving beta-cyclodextrin dissolve in double distilled water, placing in water bath with constant temperature, and making to beta-CD saturated solution; (2) dissolving triptolide in 1,2-propylene glycol, treating with ultrasound, adding beta-CD at a mol ratio of 1:2-4, heat dissolving with ultrasound, cooling for a night; and (3) placing on the millipore filter, air pump filtrating with Buchner funnel, washing with acetone, and drying to obtain white powdered form inclusion compound. The product of the invention can maintain the original property and efftect of triptolide, reduce local excitation and toxico-adverse side effect of triptolide, thereby improving pharmic security.

The invention discloses a preparation method of powder for treating senile vaginitis to solve the problem of treatment of senile vaginitis. The preparation method is characterized by comprising the steps of (1) distilling coarse powder of barks of pittosporum tobira, root of fortune apios and radix ephedrae at reduced pressure to extract volatile oil; (2) decocting tetrapanax papyriferum at reduced pressure to obtain filtrate; (3) decocting trikeraia hookeri, magnolia amoena, Chinese taxillus herb, coking malt, coking medicated leaven, leaf of mimoselike rosewood, peach gum, cassia twig and the dregs obtained in the step 1 with water to obtain filtrate for standby use; (4) combining the filtrates obtained in the steps 2 and 3, concentrating the filtrate mixture into dry extract at reduced pressure and grinding the dry extract to obtain dry extract powder; and (5) spraying the volatile oil obtained in the step 1 into the dry extract powder obtained in the step 4, mixing the materials uniformly, sieving the mixture with a 100-mesh sieve and subpackaging the powder, thus preparing the powder. Clinical experiments prove that the powder has the characteristics of good curative effects and higher safety when being used for treating senile vaginitis and is worth clinical application and popularization.

The invention discloses a preparation method for nursing infilling for cervical laceration. The nursing infilling aims to achieve the purpose of treating cervical ectropion after a tooth extraction operation. The preparation method is characterized by comprising the steps that 1, volatile oil is extracted from coarse powder of carex baccans, Sargassum thunbergii (Mert.) O.Kuntze, fragrant sarcococca herb, longleaf bastardtoadflax herb and motherwort fruits, and herb residues are reserved for standby application; 2, lycopodium and eggshell are crushed into fine powder for standby application; 3, herb of denseflower bulbophyllum, radix ranunculi ternati, asparaguns fern, cicer arietinum and the herb residues in the step 1 are evenly mixed, and water is added to the mixture and decocted two times, wherein the amount of water is 3 times that of the mixture, and each time of decocting costs 0.5 hour; decoction solutions are combined and subjected to standing, after filtration, filtrates are obtained, after concentration, the filtrates are subjected to spray drying, and primary materials are obtained; 4, the volatile oil is sprayed into the primary materials, the fine powder of lycopodium and eggshell are added to the primary materials and evenly mixed, the mixture is screened by a 60-mesh sieve, and then sterilization and split charging are carried out. Clinical experiments prove that the nursing infilling has the advantages of being good in curative effect and high in safety when being used for preventing and treating cervicitis, and worth of clinical application and popularization.

The invention discloses pilose antler effervescent tablets and a preparation method thereof, and belongs to the technical field of health-care foods and processing. The main preparation method comprises the following steps: (1) preparing pilose antler powder: selecting a protease enzymolysis assisted ultrasonic extraction method, performing extraction to obtain supernatant, performing spray dryingand performing screening; (2) performing blending according to a formula of the pilose antler effervescent tablets: mixing the pilose antler powder with malic acid, mannitol, sorbitol, maltodextrin,magnesium stearate, sodium bicarbonate and potassium bicarbonate in a certain proportion, performing uniform stirring, and performing tabletting so as to obtain the pilose antler effervescent tablets.The pilose antlers have the functions of promoting growth and development, strengthening bodies, adjusting immunity, resisting inflammation, resisting ageing, promoting wound healing and the like. Compared with ordinary tablets, the effervescent tablets disintegrate in vitro to dissolve out medicines, after the effervescent tablets are taken orally, liquid extensively distributes in gastrointestinal tracts, after about 10-30 min, the liquid is absorbed by stomachs and intestines to enter blood, and local excitation of the medicines in the gastrointestinal tracts is reduced, so that the side effects are reduced, and the effervescent tablets have the characteristics of being quick and efficient to take effect, good in instant properties, easy to absorb and the like.

The invention discloses a methylsulfonic acid pridinol oral disintegrating tablet and a preparation method thereof, wherein the oral disintegrating tablet comprises the following components by mass percentage: 2 to 8 percent of methylsulfonic acid pridinol, 40 to 80 percent of filler, 5 to 20 percent of disintegrant, 5 to 30 percent of effervescent agent, 1 to 5 percent of lubricant and 0.5 to 5 percent of flavoring agent. The methylsulfonic acid pridinol oral disintegrating tablet can be quickly disintegrated in mouth cavity and quickly absorbed, and takes effect quickly, has small first-passeffect on liver, high bioavailability, low acrimony to gastrointestinal tract, convenient taking and good taste, and is particularly suitable for the old, children and patients with difficult swallowing or inconvenient drinking of water, or in operation or coma; and the oral disintegrating tablet is prepared by adopting a method of wet granulation and compression or a method of direct compressionof powder, has simple production technique, low cost, easily-controlled quality, and stability, safety and effectiveness of the preparation, is suitable for large-scale industrial production and haswide market prospect.