55 results about "Digestive canal" patented technology

An embodiment of the present disclosure provides a reflux-preventing cushion for preventing digestive reflux that occurs in a newborn, the reflux-preventing cushion including a backrest cushion configured to be inclined at a certain angle and allow the newborn to be laid to prevent the digestive reflux, and a buttocks cushion including a pair of bands configured to cover the newborn from both sides of the body of the newborn in a state in which the newborn is laid on the backrest cushion, wherein an uninclined backrest cushion is further included on an upper portion of an inclined backrest cushion.

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

The application discloses a multi-marked endoscopic imaging lens for digestive tract, and belongs to the field of biomedical microscopic endoscopic imaging. The endoscopic imaging lens comprises a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens; the first lens focuses laser; the second lens is matched with the first lens to limit a light beam in an effective light aperture of the lens; the third lens corrects chromatic aberration; the fourth lens and the fifth lens are combined to correct aberration; the sixth lens adopts an aspheric lens to correct spherical aberration caused in a collimating and focusing system; and the seventh lens is matched with the sixth lens to correct chromatic aberration. The working spectral range of the microscopic objective lens group is 488-860 nm, the effective light aperture is less than 1.8 mm, the mechanical outer diameter is not greater than 2.6 mm, the numerical aperture at the object side or the tissue is 0.55, the imaging field of view is 450 microns, the magnification is 2.14 times, and the working distance is 84 microns. The effect of matching excitation and fluorescence spectrum of a clinically available fluorescence contrast agent is realized.

The invention provides an alimentary canal operation consumable consumption prediction system based on big data analysis, and aims to accurately predict the consumable consumption in a data driving mode. According to the system, patient data, operation data, consumable data and hospital data in a hospital EMR, an HIS, a supply chain management system and a hospital management system are collected in a multi-source mode, and after format unification, cleaning, feature extraction and normalization are carried out, a multi-model prediction system is constructed; a logic regression model is adopted to evaluate complication risks, an SVR model is utilized to predict the amount of fault-tolerant consumables when complications exist, and finally a total prediction result is dynamically output in combination with the probability of the complication risks and pushed to an electronic medical record system to assist doctors in preoperative preparation.

This invention relates to a device for electric field therapy of the digestive tract, comprising a catheter, a support, an electrode array membrane, and a pulse generator; the pulse generator includes a current sensor for sensing the current flowing through the electrode pairs; during an initial time period, in a first sequence of pulse waves, the voltage amplitude of subsequent pulses is greater than the voltage amplitude of preceding pulses, and the current sensor senses a current equal to or exceeding a lower limit value I of a set range. S(MIN) At that time, in the next time period, the absolute value U of the voltage amplitude of each pulse of the second sequence pulse wave S Equal. This invention controls the output voltage amplitude of the pulse generator through feedback from a current sensor, making treatment safer for the human body.

The invention discloses an esophageal stent covering film based on bacterial cellulose and waterborne polyurethane as well as a preparation method and application of the esophageal stent covering film, and belongs to the technical field of medical stent covering films. The preparation method of the stent covering film comprises the following specific steps: preparing a SiR / PDA composite film by a dipping-oscillation method, putting the SiR / PDA composite film into an acetobacter xylinum fermentation culture solution to realize in-situ synthesis of BC on the film, mixing 5-Fu and a WPU emulsion, pouring the mixture onto the film, and drying to prepare the 5-Fu-WPU / BC / PDA / SiR esophageal stent covering film. The preparation method provided by the invention is relatively low in cost, the stent covering film based on BC and WPU prepared by the method has good swelling property, stability, thermal stability and mechanical property, and the loaded 5-Fu has stable drug release property. The esophageal stent can be effectively applied to local administration treatment of digestive tract diseases such as esophageal cancer, and a new technical scheme is provided for functional modification of a clinical esophageal stent.

The present invention relates to a method for reducing lipid binding of brazzein and / or to method for improving digestibility of brazzein in a subject's digestive track as well as to a modified brazzein polypeptide and uses of it and to a nucleic acid encoding the same.

The present application relates to the field of medical device technology, and more particularly to a stent system capable of sustained drug delivery. The stent system comprises a coated stent and an infusion catheter. The coated stent is coated with an inner membrane and an outer membrane, forming a liquid reservoir between the inner and outer membranes for storing drugs. The outer membrane is provided with a liquid outlet, through which the drug can seep out, achieving sustained drug release. The liquid outlet of the infusion catheter is inserted into the liquid reservoir to infuse the liquid reservoir. This stent system can achieve sustained drug release, effectively resolving the problem of drug retention during digestive tract drug delivery.

The invention discloses a diphosphonic acid manganese nanoparticle, a preparation method thereof and application of the diphosphonic acid manganese nanoparticle in tumor treatment. The preparation method comprises the following steps: dropwise adding a water-in-oil emulsion system of diphosphonate into a water-in-oil emulsion system of manganese ions in stirring to establish a coordination skeleton, curing by absolute ethyl alcohol, adding a certain proportion of fat material, performing vortex hydration by a film dispersion method, and extruding to pass through a film. The diphosphonic acid manganese nanoparticle is small in particle size and good in stability, and has a pH-sensitive release characteristic; the constructed nanoparticles have a remarkable immune regulation effect, and the ICD effect and the cytotoxic effect of oxaliplatin are enhanced by directly acting on tumor cells. The diphosphonic acid manganese nanoparticles cooperate with Oxp to effectively inhibit digestive tract tumor growth and distal metastatic tumors, the dosage of Oxp can be further reduced, and the diphosphonic acid manganese nanoparticles have good in-vivo safety.

The invention discloses a primer group for simultaneously detecting four equine digestive tract bacteria and application thereof, the primer group comprises primer sequences as shown in SEQ ID NO: 1-8, and the four equine digestive tract bacteria are salmonella enteritidis, salmonella typhimurium, clostridium difficile and lawsonia intracellular. Extracting total DNA (deoxyribonucleic acid) of a sample to be detected by using the excrement sample nucleic acid extraction kit; the total DNA is used as a template, and the primer group is used for multiple PCR reaction to obtain an amplification curve. According to the invention, a primer sequence with high sensitivity and specificity is adopted, so that the quality of a detection result is ensured; the detection method is simple to operate, time-saving and labor-saving; the detection flux is high, and the reagent consumable cost is low.

The application discloses 1,2,3-triazole compounds with antitumor effects and a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. The application simply and efficiently synthesizes novel 1,2,3-triazole compounds, and does not involve heavy metal catalysts or microwave reactions. In vitro antitumor activity tests of the compounds show that the 1,2,3-triazole compounds have certain inhibitory effects on the growth of digestive tract tumor cells (human gastric cancer SGC7901 cells, human colon cancer HT-29 cells and human esophageal cancer EC9706 cells). The 1,2,3-triazole compounds can be used as candidate or lead compounds for further development, and are applied to the preparation of antitumor drugs, especially anti-digestive tract tumor drugs.

The invention relates to the technical field of auxiliary traction forceps for digestive endoscopes, and particularly discloses auxiliary traction forceps for digestive endoscopes, which comprise an outer rod tube, an adjusting part is arranged in the outer rod tube, and a clamping part is arranged above the outer rod tube; the adjusting part comprises a first gear, the first gear is arranged in the outer rod pipe, an adjusting cap is arranged at one end of the first gear, first adjusting racks are arranged on the two sides of the first gear in a meshed mode, a connecting rod is arranged above the first adjusting racks and slides in the outer rod pipe, and a second adjusting rack is arranged above the connecting rod and slides in the outer rod pipe. The second adjusting rack is meshed with a second gear, one end of the second gear is rotationally connected with the outer rod tube, and the other end of the second gear is fixedly connected with the clamping part, so that stable adjustment of the clamping part of the traction forceps at any angle of 0-90 degrees can be achieved, lesion tissue can be conveniently and flexibly clamped and taken out, and the traction forceps are effectively adaptive to the complex environment of digestive tract surgery.

The invention provides an intestinal canal anastomosis and anastomotic leakage metal stent, and relates to the technical field of medical instruments, the intestinal canal anastomosis and anastomotic leakage metal stent comprises a metal stent, a drainage tube and a stent release device, the metal stent is arranged in the stent release device before being released, and the metal stent is dumbbell-shaped after being released and comprises a first upheaval section, a second upheaval section and a groove section, the groove section is a double-layer metal net and comprises an inner-layer metal net and an outer-layer metal net, a space is formed between the inner-layer metal net and the outer-layer metal net, the inner face and the outer face of the metal support are both wrapped with silica gel coatings, a plurality of round holes communicated with the space are formed in the silica gel coating of the outer-layer metal net, the drainage tube is connected with the groove section, and the interior of the drainage tube is communicated with the space. After being released, the metal stent can block a digestive tract ventage or support liquid secreted by an anastomotic stoma, intestinal mucosa, blood vessels and ventage tissue, the liquid can enter the space between the two layers of metal stent nets through the round holes in the silica gel coating of the outer-layer metal net and is sucked out by negative pressure, cleanliness of the anastomotic stoma and the ventage can be kept, and healing of the anastomotic stoma and the ventage is promoted.

This invention discloses an internet-based digestive tract sampling capsule, comprising a capsule body with a placement cavity inside. The placement cavity houses a chip, a power supply, and a locator. The power supply provides power to the chip and locator. The locator is connected to the chip and can send location information to the chip. The chip can interact with external devices. The capsule body has multiple liquid-containing chambers arranged longitudinally. A liquid channel is formed on the left wall of each liquid-containing chamber, and a digestive fluid plug is placed within the liquid channel. A sealing plate is located on the left side of the digestive fluid plug, sealing the liquid channel. The chip can control the sealing plate to open the liquid channel. This device can locate the capsule's position and, through a combination of active and passive sampling methods, can achieve precise location identification and ensure a high sampling success rate.

The invention discloses an electric incision knife device for a digestive tract endoscopic surgical instrument control system, which comprises a surgical actuator which is positioned at the far end of the electric incision knife device and comprises a flexible arm and an incision knife arranged in the middle of the flexible arm in a penetrating manner; the driving part is located at the near end of the electric incision knife device and comprises a bottom plate, a flexible arm driving assembly and an electrode driving assembly, and the flexible arm driving assembly and the electrode driving assembly are arranged on the bottom plate; the switching part is connected between the driving part and the conduction part; the conduction part is connected between the operation actuator and the switching part and is arranged to be a nested multi-cavity tube; according to the electric incision knife device, manual control of a doctor is replaced with electric control, the movement of the incision knife is more flexible, the range is wider, and the surgical operation precision and operation efficiency are improved.

The present invention provides a temperature-corrected analyte detection method, which involves adding a series of analyte calibrators with different concentrations to an immunoassay strip, and then using an optical analyzer to measure the signal values generated after each concentration of analyte calibrator is captured on the detection pad of the immunoassay strip at each segmented temperature point. Then, with the T / C value at each segmented temperature point as the X-axis and the concentration of the analyte calibrator as the Y-axis, a corresponding equation is plotted; then, according to the selected n segmented temperature points, temperature segmentation is performed, and different formulas are used for calculation in different temperature segments. This temperature-corrected analyte detection method can be based on time-resolved fluorescence immunoassay and is used to more accurately detect myocardial markers, upper respiratory virus infections, metabolic hormones, digestive tract series markers, allergens, etc.

The invention relates to the technical field of medicine, in particular to an oral drug delivery device and a using method thereof, and the device comprises a drug storage bin used for storing drugs; the pump body is connected with the medicine storage bin and used for releasing the medicine in the medicine storage bin to the outside; the unfolding mechanism is connected with the pump body or the medicine storage bin, and an air bag capable of being expanded or shrunk is arranged in the unfolding mechanism; the controller is electrically connected with the pump body and the unfolding mechanism; the controller controls the air bag to expand to achieve retention after the oral drug delivery device enters the digestive tract, controls the pump body to act to achieve drug delivery, and controls the air bag to shrink after receiving a drug withdrawal instruction so that the oral drug delivery device can be discharged out of the body from the digestive tract. Through the arrangement of the unfolding mechanism, the staying time of the device in the digestive tract can be precisely controlled, and through the arrangement of the pump body and the medicine storage bin, the administration dosage can be designed according to needs, such as regular and quantitative administration, and the long-acting administration of oral medicine is improved.

The invention relates to a heterodimer fusion protein and application thereof. The heterodimer fusion protein of the present invention comprises: a first heavy chain comprising a first Fc region and an immunomodulator fused to the first Fc region; a light chain and a second heavy chain, the second heavy chain comprising a second Fc region, the light chain and the second heavy chain being complexed to form a targeting moiety exhibiting binding specificity for tumor antigens or immune checkpoints; the light chain, the first heavy chain and the second heavy chain are compounded to form the heterodimer fusion protein. The heterodimer fusion protein disclosed by the invention can be used for targeted therapy of digestive tract cancer, especially colon cancer, and is good in targeting property, and the tumor inhibition effect of the heterodimer fusion protein is obviously superior to that of cetuximab with the same target point.

The invention discloses a pair of foreign body forceps for a digestive endoscope. The pair of foreign body forceps comprises a magnetic attraction control assembly, a clamping transmission structure, an operating handle, a fixed handle and a hinge point. The invention belongs to the technical field of foreign body digestion forceps, and can relieve the burden of an operator, so that the operator can pay more attention during an operation; when the foreign matter in the melting channel needs to be clamped, the piston piece drives the foreign matter clamping pieces to turn over in the direction away from the internal spring through magnetic adsorption force, meanwhile, when the piston piece is away from the internal spring, the magnetorheological fluid in the spring cavity recovers to be in the fluid state, and at the moment, the four sets of foreign matter clamping pieces can clamp and take out the foreign matter; the operating handle and the fixed handle can be further kept in a separated state through a spring piece, so that the clamping effect of the four groups of foreign matter clamping pieces on the foreign matter is further stabilized, and the burden of an operator is further relieved; according to the scheme, the structure is simple, and the use cost is reduced while automatic experience is provided.

The utility model discloses an innovative digestive tract electronic endoscope which comprises a main body tube, one end of the main body tube is provided with a bending part, an inner tube is arranged between the main body tube and the bending part, one end of the main body tube far away from the bending part is fixedly connected with an operating handle, one end of the bending part is provided with a camera shooting assembly, and the other end of the bending part is provided with a camera shooting head. The camera shooting assembly comprises a camera fixedly connected to the interior of the bent part, and a functional pipeline A and a functional pipeline B are symmetrically arranged in the camera. According to the innovative electronic endoscope for the digestive tract, the visual field range of the electronic endoscope is expanded through the flexible and soft bending part, operation is easy and convenient, meanwhile, the arranged main control line connector can be connected with electronic equipment with Windows, swan and Android operating systems, and the arranged two sets of functional interfaces can be connected with different accessories according to requirements; therefore, different examination or operation requirements can be met.

This invention discloses a laryngeal mask airway with a liquid level sensor, comprising a tube, a mask body, and a liquid level sensor. The tube has a mask connection end and a digestive cavity for the flow of waste fluid generated during implantation ventilation. The mask body has a tube connection end and a mask implantation end, which are sealed together. The mask body has a digestive chamber communicating with the digestive cavity. The mask body also has a front side facing the respiratory tract and a rear side facing away from the respiratory tract. The digestive chamber has a digestive opening for communication between the digestive chamber and the digestive tract, located near the mask implantation end. The liquid level sensor is located within the digestive chamber to sense the waste fluid level within it. This invention's laryngeal mask airway with a liquid level sensor can sense the liquid level in the digestive chamber to guide its intermittent drainage, reducing harm to the patient and improving patient comfort.

The application provides a microorganism marker group, a tumor prognosis prediction model establishment method and application thereof, and relates to the technical field of biomedicine. The microorganism marker group is related to a preset total survival time. Based on the microorganism marker group obtained from tumor tissues and paracancer normal tissues, the prognosis prediction accuracy and sensitivity of a digestive tract tumor can be effectively improved.

The utility model relates to a replaceable mould for manufacturing alimentary canal water vapor suction valve component, which comprises an upper mould component and a lower mould component, the lower mould component comprises a lower mould plate, support columns fixed on two sides of the lower mould plate, a mounting block and a lower mould base, a central baffle is arranged at the central position of the upper surface of the mounting block, a guide rail groove is arranged on the upper surface of the mounting block, and the guide rail groove is arranged on the lower mould base. Side baffles are arranged on the two sides of the guide rail groove, a guide rail protruding downwards and corresponding to the guide rail groove is arranged on the lower surface of the lower die base, one side of the lower die base makes contact with the center baffle, a pressing block is arranged between the other side of the lower die base and the side baffles, one side of the pressing block abuts against the lower die base, the other side of the pressing block abuts against the side baffles, and the pressing block is provided with a downward pressing inclined face. The lower die base is provided with a pressed inclined face, and the pressing inclined face abuts against the pressed inclined face. A screw rod in threaded connection with the pressing block is arranged on the pressing block, extends downwards and is in threaded connection with the mounting block; according to the utility model, the production cost is greatly reduced, and the production efficiency is improved.

The invention discloses a digestive tract tumor recognition method and system and a medium, and relates to the technical field of medical image processing.According to the method, the step length and the layer number of Z-axis sampling are dynamically optimized according to the calculated tangent plane inclination angle, and on the premise that it is guaranteed that a complete glandular tube three-dimensional structure is collected, the number of layers of Z-axis sampling is increased; the problems of local defocus and form distortion caused by tissue beveling are effectively avoided, and the definition of the image and the interlayer registration precision are remarkably improved. In addition, a virtual vertical section reconstruction strategy is introduced, geometric deformation can be corrected in a three-dimensional voxel space, an observation view meeting a standard anatomical view angle is provided, and therefore interference of film production artifacts on diagnosis is eliminated. And through distinguishing the mucous membrane layer and the non-mucous membrane layer and applying a differentiated scanning strategy, while the data quality of a key region is improved, the scanning time and data redundancy of a non-diagnosis region are greatly reduced, dual optimization of scanning precision and efficiency is realized, and the accuracy and robustness of automatic recognition of digestive tract tumors are remarkably improved.

The present application provides a cleaning brush assembly for a digestive endoscope, belonging to the field of endoscope cleaning, including a connecting pipe and a clamp. A cleaning component is arranged in the slot of the connecting pipe. The cleaning component includes a sleeve, a connecting shaft, a brush strip, a pressing component and a cleaning component. The two ends of the sleeve are open and communicated with the two side walls of the connecting pipe. In the present invention, by providing the connecting shaft, the brush strip, the pressing component and the cleaning component, through the continuous rotation of the connecting shaft, the brush strip is driven to rotate reciprocally relative to the outer surface of the snake tube. Through the frictional force between the brush strip and the snake tube, the outer side wall of the snake tube is cleaned. At the same time, under the organic cooperation of the connecting shaft, the pressing component and the cleaning component, through the extrusion of the snake tube by the cleaning component, the cleaning effect on the snake tube is further improved. The linear motion of the cleaning component relative to the connecting shaft and the frictional force between the cleaning component and the snake tube can achieve a good cleaning effect.

The utility model relates to the technical field of medical apparatus and instruments, and discloses a three-cavity jejunum nutrition tube with a support function, which is characterized by comprising a tube body; a suction cavity, an intestinal feeding cavity and a pressure adjusting cavity are formed in the tube body at intervals, and the suction cavity, the intestinal feeding cavity and the pressure adjusting cavity are all arranged to be vertically communicated channels and extend to the near end of the tube body to form a suction cavity tube opening, an intestinal feeding cavity tube opening and a pressure adjusting cavity tube opening which are independent. And the side holes are formed in the side wall of the tube body and communicated with the suction cavity, the side holes are divided into two groups, and when in use, the two groups of side holes are respectively positioned on the two sides of an obstruction part. The three-cavity jejunum nutrient canal has a support function, can promote emptying of digestive juice through the obstructed part of the digestive tract, and can remarkably improve the nutritional status of obstructed patients.

The invention relates to the technical field of small molecule drugs, in particular to an isoquinoline drug and application thereof to improvement or treatment of digestive tract tumors. The invention aims to provide a compound, a pharmaceutical composition containing the compound and application of the compound in treatment of colorectal cancer and gastric cancer, and provides a 3, 13-substituted berberine derivative which is low in toxicity, does not affect growth of human normal cells, and has a wide application prospect in development of novel anti-tumor drugs and application of the 3, 13-substituted berberine derivative in treatment of colorectal cancer and gastric cancer. Particularly, the compound has a very good application prospect in the aspect of development of anti-digestive tract tumor drugs.

Abametapir or a pharmaceutically acceptable salt thereof has antitumor activity and significant antitumor effects on gynecological tumors, digestive tract tumors, lung tumors, lymphomas, and the like. Abametapir has a significant inhibitory effect on the growth and development of various human tumor cells and tumors in tumor-bearing mice, and especially has a good inhibitory effect on triple-negative breast cancer. Abametapir or the pharmaceutically acceptable salt thereof has an effective antitumor effect by means of oral administration.