15 results about "Digestive canal" patented technology

Disclosed is an oral apparatus for injection administration in the digestive tract, comprising a housing, a trigger assembly, and an administration assembly. The housing comprises a top cover at the upper part thereof, a middle housing placed in the middle, and a base located at the bottom. The material density of the middle housing is less than the material density of the base, so that the apparatus is in the shape of a roly-poly toy. The trigger assembly comprises a soluble fixing member, an elastic member, and a transmission member. The administration assembly comprises a microneedle and a drug. The apparatus provided by the present invention, by means of an arranged liquid storage bag, greatly increases the drug loading capacity and can theoretically achieve a drug loading capacity of 50 mg, which is a significant improvement over the prior art.

The present invention relates to a method for reducing lipid binding of brazzein and / or to method for improving digestibility of brazzein in a subject's digestive track as well as to a modified brazzein polypeptide and uses of it and to a nucleic acid encoding the same.

The invention discloses a primer group for simultaneously detecting four equine digestive tract bacteria and application thereof, the primer group comprises primer sequences as shown in SEQ ID NO: 1-8, and the four equine digestive tract bacteria are salmonella enteritidis, salmonella typhimurium, clostridium difficile and lawsonia intracellular. Extracting total DNA (deoxyribonucleic acid) of a sample to be detected by using the excrement sample nucleic acid extraction kit; the total DNA is used as a template, and the primer group is used for multiple PCR reaction to obtain an amplification curve. According to the invention, a primer sequence with high sensitivity and specificity is adopted, so that the quality of a detection result is ensured; the detection method is simple to operate, time-saving and labor-saving; the detection flux is high, and the reagent consumable cost is low.

This invention discloses an internet-based digestive tract sampling capsule, comprising a capsule body with a placement cavity inside. The placement cavity houses a chip, a power supply, and a locator. The power supply provides power to the chip and locator. The locator is connected to the chip and can send location information to the chip. The chip can interact with external devices. The capsule body has multiple liquid-containing chambers arranged longitudinally. A liquid channel is formed on the left wall of each liquid-containing chamber, and a digestive fluid plug is placed within the liquid channel. A sealing plate is located on the left side of the digestive fluid plug, sealing the liquid channel. The chip can control the sealing plate to open the liquid channel. This device can locate the capsule's position and, through a combination of active and passive sampling methods, can achieve precise location identification and ensure a high sampling success rate.

The invention relates to the technical field of medicine, in particular to an oral drug delivery device and a using method thereof, and the device comprises a drug storage bin used for storing drugs; the pump body is connected with the medicine storage bin and used for releasing the medicine in the medicine storage bin to the outside; the unfolding mechanism is connected with the pump body or the medicine storage bin, and an air bag capable of being expanded or shrunk is arranged in the unfolding mechanism; the controller is electrically connected with the pump body and the unfolding mechanism; the controller controls the air bag to expand to achieve retention after the oral drug delivery device enters the digestive tract, controls the pump body to act to achieve drug delivery, and controls the air bag to shrink after receiving a drug withdrawal instruction so that the oral drug delivery device can be discharged out of the body from the digestive tract. Through the arrangement of the unfolding mechanism, the staying time of the device in the digestive tract can be precisely controlled, and through the arrangement of the pump body and the medicine storage bin, the administration dosage can be designed according to needs, such as regular and quantitative administration, and the long-acting administration of oral medicine is improved.

The application provides a microorganism marker group, a tumor prognosis prediction model establishment method and application thereof, and relates to the technical field of biomedicine. The microorganism marker group is related to a preset total survival time. Based on the microorganism marker group obtained from tumor tissues and paracancer normal tissues, the prognosis prediction accuracy and sensitivity of a digestive tract tumor can be effectively improved.

The invention discloses a digestive tract tumor recognition method and system and a medium, and relates to the technical field of medical image processing.According to the method, the step length and the layer number of Z-axis sampling are dynamically optimized according to the calculated tangent plane inclination angle, and on the premise that it is guaranteed that a complete glandular tube three-dimensional structure is collected, the number of layers of Z-axis sampling is increased; the problems of local defocus and form distortion caused by tissue beveling are effectively avoided, and the definition of the image and the interlayer registration precision are remarkably improved. In addition, a virtual vertical section reconstruction strategy is introduced, geometric deformation can be corrected in a three-dimensional voxel space, an observation view meeting a standard anatomical view angle is provided, and therefore interference of film production artifacts on diagnosis is eliminated. And through distinguishing the mucous membrane layer and the non-mucous membrane layer and applying a differentiated scanning strategy, while the data quality of a key region is improved, the scanning time and data redundancy of a non-diagnosis region are greatly reduced, dual optimization of scanning precision and efficiency is realized, and the accuracy and robustness of automatic recognition of digestive tract tumors are remarkably improved.

This invention relates to the field of medical device technology, and more particularly to an acid and alkali resistant medical electro-adhesive surface. The invention provides an acid and alkali resistant medical electro-adhesive surface comprising a positive backbone ionogel and a negative backbone ionogel; the raw materials for preparing the positive backbone ionogel include polyvinyl alcohol, gelatin, chitosan and its derivatives, and conductive metal ion salts; the polyvinyl alcohol and / or chitosan and its derivatives include quaternary ammonium groups; the raw materials for preparing the negative backbone ionogel include sodium alginate and calcium chloride. The acid and alkali resistant medical electro-adhesive surface possesses characteristics of low-voltage drive, molecular-level adhesion, and adaptability to various tissues in the digestive tract.

The application discloses a polypeptide specifically binding to Sestrin2 protein and application thereof in treatment of digestive tract cancer. Specifically disclosed is a STAMBPL1 polypeptide with an amino acid sequence of SEQ ID No. 1, which is a polypeptide specifically binding to Sestrin2 protein and can block the interaction between Sestrin2 and STAMBPL1 through competitive binding. The application further provides a chimeric peptide tat-STAMBPL1 with cell permeability comprising the STAMBPL1 polypeptide and a cell-penetrating peptide. The polypeptide and the chimeric peptide of the application have high affinity, clear target, target the Sestrin2 / STAMBPL1 interaction site, and can effectively inhibit tumor (especially digestive tract tumor) formation. The application further provides an anti-tumor drug comprising the STAMBPL1 polypeptide and / or the chimeric peptide tat-STAMBPL1.

The invention discloses a foldable anastomat anvil head, and belongs to the technical field of medical instruments. Comprising a central shaft sleeve piece, a foldable nail anvil base, a driving assembly and a rope body. The foldable nail anvil base comprises two nail anvil caps capable of being separated and combined, the two nail anvil caps have a folded state and an unfolded state, the driving assembly is connected with the center shaft sleeve piece and the two nail anvil caps, and the rope body is connected with the center shaft sleeve piece, the driving assembly and the two nail anvil caps. By arranging the driving assembly and the rope body, the two nail anvil caps are kept in the folded state that the nail anvil caps are parallel to the central shaft sleeve piece and are separated from each other, the transverse diameter of the nail anvil base is reduced, the operation difficulty of placing the nail anvil head into the broken end of the esophagus in laparoscopic digestive tract circular anastomosis reconstruction is remarkably reduced, and the operation efficiency is improved. The operation efficiency and the anastomosis safety are improved, and the good clinical application value is achieved.

The invention provides an oral drug delivery device and a drug delivery method, belongs to the technical field of medical instruments, and aims to solve the problems that precise and controllable release is difficult to realize and the amount cannot be dynamically adjusted in the conventional oral drug delivery. The device comprises a medicine storage bin, a power assembly for applying pressure to medicine fluid, an electric control valve, a controller for driving the valve to control the administration dosage, and a power supply assembly. The method comprises the steps that in the digestive tract, pressure is applied to the medicine storage bin through the power assembly, and the electric control valve is electrically driven through the controller to control the release dosage of medicine fluid. According to the application, medicine can be released regularly and quantitatively, and an in-vitro instruction can be received through wireless communication to dynamically adjust the dosage, so that the stability of the blood concentration is maintained, and the flexibility and the safety of treatment are improved.

The utility model relates to a kind of digestive tract objective lens, the optical structure of digestive tract objective lens includes first lens, second lens, third lens, diaphragm, fourth lens, fifth lens, sixth lens sequentially arranged from object side to image side direction along optical axis, the first lens, second lens, third lens combination is front group system, fourth lens, fifth lens, sixth lens combination is rear group system, front group system is divided into gastroscope front group system and enteroscope front group system two kinds of forms, rear group system is common to gastroscope front group system and enteroscope front group system, the optical total length after the combination of gastroscope front group system and rear group system, the optical total length after the combination of enteroscope front group system and rear group system is identical. The utility model design is reasonable, and aberration is balanced reasonably, with small volume, imaging quality is good, lens common rear group, gastroscope system and enteroscope system common module and the like features.

The invention relates to the field of computer-aided diagnosis, and discloses a small sample learning-based alimentary canal endoscopic lesion classification model training method, which comprises the following steps of: unifying labeling information of different modals into the same coordinate system on the basis of a constructed modal time sequence diagram to form three-dimensional space-time aligned multi-modal data, and classifying to obtain a multi-modal lesion classification model; performing dynamic cross-modal attention fusion on the classified multi-modal data to generate a dynamic cross-modal attention weight map, obtaining a cross-modal sharing feature and a time sequence dynamic feature based on the weight map, combining the cross-modal sharing feature and the time sequence dynamic feature to form a cross-modal time sequence consistency feature, and combining the cross-modal time sequence consistency feature with the cross-modal attention weight map to obtain a cross-modal attention weight map; according to the method, the meta-learning classification model is trained, the attention weight is visualized by using the thermodynamic diagram, the trained meta-learning classification model is exported and deployed to an actual application platform, and new digestive tract endoscopic images are classified, so that the training efficiency and the classification accuracy are improved, and the robustness of the model is enhanced.