299 results about "Drug withdrawal" patented technology

The invention discloses a system for monitoring and traceably managing an organic livestock growth, slaughter and distribution process. The system, based on Internet of things technology, can help breeding enterprises establish perfect production files, establish data base of meat product traceability, manage safety production, and establish epidemic prevention records; helps a government supervision department achieve livestock production process supervision and control. In addition, being capable of monitoring prohibited veterinary drugs, drug additives, drug withdrawal period in real time, the system can help users avoid the use of prohibited veterinary drugs to prevent livestock slaughter in the withdrawal period and improve animal safety so as to guarantee people's health and life safety, to monitor a animal growth process and achieve fresh meat product traceability, to ensure organic and healthy ecological meat. Further, the system raises the economic benefits of farming enterprises so as to guarantee the profits of the consumers, the breeding enterprises and the government supervision department.

The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.

The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pathway in the neuronal cells close to or subsequent to the time of excitatory insult, thereby producing a synergistic acute neuroprotective effect in the neuronal cells. The invention also provides a method of preventing or reducing the severity of a neurologic condition in a subject by administering to the subject EPO or an active fragment or analog thereof at a dose of at most 2000 U/kg; and administering to the subject an IGF or an active fragment or analog thereof, thereby providing neuroprotection and preventing or reducing the severity of the neurologic condition. Such a method can be used to prevent or reduce the severity of, for example, Alzheimer's disease, Parkinson's disease, Huntington's disease, epilepsy, amyotrophic lateral sclerosis, multiple sclerosis, a movement disorder, HIV-associated dementia, HIV-associated neuropathy, neuropathic pain, migraine, glaucoma, drug addiction, drug withdrawal, drug dependency, depression or anxiety.

A vibrational instrument which is therapeutically beneficial in treating the person suffering from afflictions such as headache, sinus congestion and pressure, and withdrawal due to drug dependency includes a member capable of transmitting vibrational waves through the teeth, jaw and sinus tissue for disposal between teeth of the person. A method of treatment is also provided.

The invention discloses a traditional Chinese medicine composition for treating subacute thyroiditis. The composition is a preparation prepared from the following raw materials by weight: 15-30 parts of hedyotis diffusa, 9-15 parts of honeysuckle, 15-30 parts of dandelion, 15-30 parts of Chinese violet, 9-15 parts of root of common peony, 9-15 parts of radix scrophulariae, 9-15 parts of peach kernel, 9-15 parts of baked turtle shell and 15-30 parts of sweet wormwood. According to clinical study on the treatment of subacute thyroiditis, the traditional Chinese medicine composition provided by the invention has total effective rate of 93.34%, which is significantly better than 73.33% of a prednisone group, and can effectively reduce erythrocyte sedimentation rate and CRP of subacute thyroiditis patients, and effectively improve clinical symptoms of the patients; although the cooling time, improvement time of neck pain and regression time of neck tenderness are longer than those of the prednisone group, the goiter or nodule disappearance time shows no obvious difference from those of the prednisone group; relapse rate after drug withdrawal is 3.33%, which is significantly lower than 20% of the prednisone group; and the composition has little adverse reaction, which is significantly lower than that of the prednisone group. The invention also discloses a preparation method of the traditional Chinese medicine composition granules.

The invention discloses novel application of imatinib and a derivative thereof and provides novel application of imatinib and the derivative thereof to preparation of drugs for preventing and/or treating drug addiction and preparation of drugs for preventing and/or treating relapse after drug withdrawal. According to the novel application, a classic rat sensitization and conditioned place preference animal model for evaluating addiction is adopted, the influences of imatinib and the derivative methanesulfonic acid imatinib on expression of the recrudescence behavior and sensitization behavior appearing after withdrawal of the conditioned place preference of a rat is formed are observed respectively, and the result indicates that imatinib and the derivative methanesulfonic acid imatinib have an inhibitory effect on morphine addiction and have the effect of preventing relapse after withdrawal of morphine addiction.

The invention relates to a traditional Chinese medicine for treating hypertension. The traditional Chinese medicine is characterized by being prepared from the following traditional Chinese medicine raw medicinal materials in parts by weight: 2-15 parts of apocynum venetum, 2-20 parts of wild chrysanthemum flower, 10-30 parts of haw, 2-10 parts of selfheal spike, 3-10 parts of perilla frutescens, 3-15 parts of hooked uncaria, 6-15 parts of medlar, 3-10 parts of abalone shell and 6-15 parts of eucommia bark. The traditional Chinese medicine for treating the hypertension has the advantages that the blood pressure of patients can be reduced in a short time in a manner that the patients take the medicine, the curative effect is stable, the blood pressure cannot be immediately restored to a high-pressure level once drug withdrawal occurs, the preparation method is simple, and the cost is low.

The invention discloses a method for detecting HBV PgRNA in blood of a patient with hepatitis b. After pgRNA is extracted, the extracted HBV pgRNA is purified by RNase-free Dnase I; and quantitative determination on pgRNA is achieved by adopting the qRT-PCR method. The invention further provides a kit for detecting the HBV PgRNA in blood of the patient with hepatitis b. The method has the following effects: firstly, the method adopts blood detection, is noninvasive, is normal and is capable of being applied on a large scale; secondly, PgRNA with ultralow carrying capacity in the blood can be detected; and thirdly, the kit and the application thereof in predicating NA drug withdrawal can be used for researching the shape of Chinese PgRNA shape, so that fundamental research data is provided for developing a PgRNA drug. A scheme is provided for solving the problem of finding clinical criteria and a biological marker for predicating NA drug withdrawal, which is one of ten to-be-solved problems of hepatitis B clinical guideline.

The present invention provides pharmaceutical compositions for intranasal delivery of a benzodiazepine. The composition may contain a therapeutically effective amount of a benzodiazepine or a pharmaceutically acceptable salt thereof, and a permeation enhancer. The permeation enhancer may be propylene glycol or a Hsieh permeation enhancer. The present compositions have excellent bioavailability. After administration of the present compositions, therapeutically effective plasma levels of the benzodiazepine may be achieved rapidly. The present pharmaceutical composition may be used to treat a patient suffering from anxiety, epilepsy, insomnia, agitation, seizures, muscular disorders, alcohol dependence, and drug withdrawal.

The invention relates to a method for quantitatively detecting TRAb plate-type fluorescent enzyme immunity and an application thereof. The method is characterized in that recombination human thyroxin stimulating hormone receptor (hTSHR) extracellular domain amino terminal proteins is taken as antigen to coat a perforated plate and then is sealed by PBST containing 1-5% of BSA; anti-hTSHR first antibody or standard substance, enzyme-labeled second antibody, fluorescent substrate and stopping solution are sequentially added by utilizing the perforated plate as a carrier; and finally fluorescence intensity is measured on a fluorescence illuminant analyzer. The clinical detection of TRAb which mainly comprises TSAb in patient serum has great significance on pathogenic diagnosis, curative effect observation and drug withdrawal occasion determination of GD hyperthyroidism. The invention performs the fluorescence enzyme immunoassay by utilizing a multi-hole site plastic plate as a solid carrier, has easy sheet material source, low cost and easy promotion, and the method is distinctive, sensitive, accurate and stable, thereby being suitable for clinical requirement and promotion.

The present invention provides an acne gel containing traditional Chinese medicine components, the acne gel containing the traditional Chinese medicine components comprises the following active ingredients by weight: 250-1000 parts of acne treatment traditional Chinese medicine extract, 5-8 parts of sulfur, 3-5 parts of venenum bufonis, 5-15 parts of vitamin B6, 1-5 parts of vitamin C glucoside, 5-10 parts of zinc chloride, 0.5-1 part of Allantoin, 0.5-1%wt of an excipient, 0.05-0.15%wt of a surfactant, 0-1%wt of a preservative and 5-10%wt of a solvent; the acne treatment traditional Chinese medicine extract comprises the following raw materials by weight: 30-50 parts of Coptis chinensis, 40-50 parts of Scutellaria baicalensis, 40-50 parts of herba schizonepetae, 30-50 parts of fructus forsythiae, 40-50 parts of radices sileris, 30-50 parts of Fructus Gardeniae, 40-50 parts of immature bitter orange, 50-100 parts of radix sophorae flavescentis, 100-200 parts of dandelion, 30-40 parts of calendula officinalis, 20-30 parts of Tribulus terrestris, 40-50 parts of radix angelicae, 40-50 parts of radix paeoniae alba, 40-50 parts of Poria cocos and 20-40 parts of licorice. The acne gel containing the traditional Chinese medicine components does not contain hormones and antibiotics, and is safer to use, after drug withdrawal, acnes are not easy to recur, and the acne gel containing the traditional Chinese medicine components has the advantages of anti-inflammatory, antipruritic and detoxification effects, long duration and few toxic and side effect, and can also complement skin nutrition, improve the antioxidant capacity of the skin, promote skin healing and eliminate pockmarks.

The present invention relates to a beverage for relieving anxious syndrome of drug withdrawal man in the stage of recovery with obvious effect. The beverage contains 5 ml-200ml/L of aqueous extract of Baihuarong (a Chinese kerbal medicine).

The invention discloses an Internet-based patients' medicine taking intervention method, comprising the steps that firstly specific theoretical guidance is conducted, in which the cognition degree ofdiseases to patients can be increased through health education, and drug withdrawal without permission may cause severe harm, and thereby the compliance of patients' taking medicine can be improved; secondly, automatic reminding of medicine taking can be conducted via App, which means that some patients might forget to take medicines due to the fact that no obvious symptoms are revealed or symptoms are improved after a period of time, or some patients may miss taking medicines because of the complicated medicine-taking scheme, and through the App, a reliable and accurate medicine-taking remindcan be provided for patients. The invention is advantageous in that under the mode of Internet+ and through combining APP of mobile phones with Internet technology, a new intervention means of medicine taking for patients can be practiced; with the design, a series of intervention measures improving the compliance of medicine taking for patients can be realized; new thoughts are provided for improving the compliance of medicine taking for patients and for improving patient prognosis can be provided.

The invention is based on the surprising finding that treatment with a chemotherapeutic agent such as 5-fluorouracil (5-FU) and an autophagy inducer effectively inhibit the continued growth of, and prevent the recovery following drug withdrawal, of cancer cells. In vivo, drug resistance from a failure to adequately engage in apoptotic programmed cell death leads to a recurrence of cancer and tumours can remain dormant for periods of time before re-emerging as drug resistant metastases. It has been hypothesised that autophagy (Type II cell death) may help cancer cells survive in response to growth limiting conditions, such as nutrient depletion, hypoxia, absence of growth factor, or presence of cytotoxic drug. LiCl is a known autophagy inducer and accelerates cell survival to autophagic programmed cell death.

The present invention provides a novel α-conotoxin peptide, pharmaceutical composition and use thereof. The present invention further provides a propeptide of the conotoxin peptide, a nucleic acid construct, expression vector and transformed cell of the conotoxin peptide as well as a fused protein of the conotoxin peptide. The present invention discloses a method for blocking acetylcholine receptors as well as a use of the conotoxin peptide in the manufacture of a medicament. The α-conotoxin peptide of the present invention can specifically block acetylcholine receptor (nAChRs, such as α3β2 nAChRs, α6/α3β2β3 nAChR or α3β4 nAChR or α6/α3β4 nAChR), has activity for treatment of neuralgia, addiction, Parkinson's disease, dementia, schizophrenia, cancers, and can be used in the manufacture of a medicament for analgesia and smoking cessation and drug-withdrawal, a medicament for treatment of mental diseases and cancers, as well as a tool drug for neurosciences.

The invention relates to the technical field of fecal bacteria capsules, in particular to an intestinal flora capsule for treating methylamphetamine addiction withdrawal and a preparation method. Thepreparation method comprises the steps that fresh feces of healthy people is adopted to be stirred with sterile physiological saline to prepare a suspension, filtering and residue removing are conducted, and intestinal flora liquid is obtained; by means of a special culture medium, ruminococcus albus and ruminococcusflavefaciens are extracted from the intestinal flora liquid for culture, and a target bacteria solution is obtained; CaCl2 is added into the target bacteria solution, and then mixed with a glue solution prepared from sodium alginate and pectin, a chemical cross-linking reaction isconducted at room temperature, filtering and cleaning are conducted, intestinal flora particles are obtained and wrapped in the capsule, and the intestinal flora capsule is obtained and preserved at room temperature in the dark. The prepared intestinal flora capsule can adjust the intestinal flora composition of an addict, withdrawal of the methylamphetamine drug addiction is achieved, the cravingof the addict on the drugs is gradually reduced, the intestinal microecological balance of the addict is controlled, and the drug withdrawal rate is effectively improved.

The invention discloses a formula for treating the hidrosis of children. The formula is characterized by comprising the following materials by weight: 30g of radix saposhnikoviae, 20g of blighted wheat, 15g of radix pseudostellariae, 10g of rhizoma atractylodis macrocephalae, 6g of Chinese ephedra root and 3g of liquorice. The use method and the dosage are as follows: decocting with small fire, taking one dose for every day and by three times and adopting three days as one treatment course; for the treating effect, 42 patients in 50 patients with hidrosis of children can be obviously treated. The formula disclosed by the invention is invented for solving the problems that the existing traditional treatment for the hidrosis of the children mainly adopts western medicines to inhibit the secretion of the sweat gland and adjust the vegetative nerve function, but the effect is very poor, the side effect is larger, and the relapse is easy after drug withdrawal.

The invention relates to a procedure for screening of neuroactive substance and the associated neural plasticity by treating fruitfly Drosophila melanogaster adult males with fly medium containing either of the neuroactive compounds strychnine, pentylenetetrazol, pilocarpine hydrochloride, tetraethylammonium chloride, lithium carbonate and ethosuximide, subjecting flies to negative geotaxis and horizontal locomotor assays, observing the height climbed and distance walked by and the climbing speed of the flies wherein an altered height climbed by flies under drug treatment and a long-lasting alteration in climbing speed of flies after drug withdrawal is most characteristic of the neuractive compounds.

The invention relates to a pharmaceutical composition using liensinine to work in coordination with paclitaxel for chemotherapy and an application method of the pharmaceutical composition. The pharmaceutical composition comprises a liensinine injection solution and a chemotherapy drug paclitaxel injection solution. The application method comprises the following steps: (1) performing intravenous injection of liensinine once daily according to the dose that actual dosage in the liensinine injection solution to the body weight of a patient is equal to 4.88mg/kg; (2) performing intravenous injection of paclitaxel once according to the dose that the actual dosage in the paclitaxel injection solution to the body weight of the patient is equal to 2.562mg/kg on the day of injecting liensinine according to the step (1); (3) performing intravenous injection of the paclitaxel injection solution once again according to the dose in the step (2) on the twenty-second day; and (4) determining whether to circulate according to the method of the steps (1)-(3) or not, the number of circulation times and the intermediate drug withdrawal time from the forty-third day according to the bearing capacity and the treatment effect of a patient body. Compared with the prior art, in the aspect of inhibiting and killing various malignant tumor cells, the pharmaceutical composition provided by the invention has the advantages of reducing the dosage, shortening the treatment period and reducing the occurrence of toxic and side reactions.

The invention relates to a drug-addiction-stopping tea, and especially relates to a drug-addiction-stopping tea which has no toxic and side effects, and does not cause untoward effect, addiction and dependence. Tea leaves and traditional Chinese medicines are combined together, so that the drug-addiction-stopping tea of the invention has the special performance that 'medicines achieve the effects by means of the tea, and the tea achieves the effects by means of the medicines', belongs to a tea treasure usable as both food and medicine, and is capable of effectively reducing the relapse rate to a lowest limit or zero; and the drug-addiction-stopping tea has a high drug withdrawal rate, a low relapse rate, good curative effect and almost no toxic and side effects, does not cause untoward effect, addiction and dependence, and helps to comprehensively improve drug rehabilitation success rate.

The invention relates to an infusion control system and an infusion system. The infusion control system comprises a drip rate detecting device, a drug withdrawal control device and a controller; the drip rate detecting device comprises a dual-beam photoelectric switch; the dual-beam photoelectric switch comprises a transmitter and a receiver; the transmitter and the receiver are in aligning arrangement on both sides of a drip path of a dripper; the drug withdrawal control device includes a motor and a pusher assembly; the pushing assembly is disposed on an adjustment star wheel of a flow regulator; the pushing assembly is in driving connection to the motor; the pushing assembly is used to push the star wheel to move under the drive of the motor; the controller is electrically connected tothe transmitter and the receiver; and the controller is also electrically connected to the motor. When the infusion control system is applied to an infusion device, the infusion can be automatically stopped after the liquid in an infusion bottle is emptied, thereby avoiding the problem of returning blood of a patient and cause of unnecessary loss and pain, and improving the safety of the infusion.

The invention discloses a composition for the Alzheimer's disease, and further discloses a processing method of the composition. The processing method comprises the following steps: preparing huperzia serrata coarse powder from huperzia serrata plant; preparing dendrobium candidum coarse powder from dendrobium candidum; preparing lycium barbarum coarse powder from lycium barbarum; preparing anthocyanin coarse powder from purple sweet potato; preparing the obtained huperzia serrata coarse powder, dendrobium candidum coarse powder, lycium barbarum coarse powder and anthocyanin coarse powder into tablets or capsules according to proportion. Polysaccharide and dendrobine of dendrobium candidum, huperzia serrata of huperzia serrata, polysaccharide and isoflavone of lycium barbarum and anthocyanin are scientifically selected for the first time, so as to develop the health product for obviously preventing and treating the Alzheimer's disease. The production process is simple, the cost is low, and the product with obvious curative effects can be obtained without purification of the chemical components. The composition is obvious and stable in curative effects on the Alzheimer's disease, and the relapse is avoided within 1-2 years after drug withdrawal.