53 results about "Drug withdrawal" patented technology

The invention discloses a synthesis method of N-goose deoxycholyl-L-aspartic acid and application of the N-goose deoxycholyl-L-aspartic acid in preparation of a medicine for improving metabolism-related fatty liver diseases. According to the method provided by the invention, chenodeoxycholic acid and L-dimethyl aspartate hydrochloride are taken as raw materials, and a chenodeoxycholic acid-dimethyl aspartate intermediate is synthesized, so that a target compound-N-chenodeoxycholyl-L-aspartic acid with a brand new structure is efficiently prepared. The compound shows a treatment effect superior to that of obeticholic acid (OCA) in an animal model, and can effectively improve multiple indexes such as fatty degeneration, inflammation and fibrosis of the liver. The invention provides a brand new solution for major clinical challenges of insufficient curative effect, large side effect, drug withdrawal rebound and the like of the current MAFLD treatment drug, and provides a candidate compound with a wide prospect for developing a novel efficient MAFLD treatment drug.

The invention discloses a substituted heterocyclic compound containing an α-ketone skeleton and a use thereof, and relates to the field of pharmaceutical chemistry, and specifically relates to a substituted heterocyclic compound containing an α-ketone skeleton or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing these compounds and their medical uses, in particular, an application of the substituted heterocyclic compound as a fatty amide hydrolase (FAAH) inhibitor in the preparation of a drug for preventing or treating diseases related to FAAH, including inflammatory diseases, rheumatoid arthritis, hepatitis, liver fibrosis, autoimmune diseases, pain, depression, pain-depression comorbidity, autism, social phobia, Tourette syndrome, neurodegenerative diseases, anxiety post-traumatic stress (PTSD), cannabinoid use disorder, drug withdrawal, and anti-tumor treatment.

The invention discloses a novel traditional Chinese medicine honeyed pill for treating alopecia, and relates to the technical field of traditional Chinese medicine preparations. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: radix rehmanniae praeparata, angelica sinensis, raw radix paeoniae alba, semen cuscutae fried with wine, radix saposhnikoviae, gastrodia elata, ligusticum wallichii, radix ophiopogonis, asparagus cochinchinensis, radix bupleuri, radix puerariae, cassia twig, radix curcumae, caulis spatholobi and other traditional Chinese medicines which are subjected to superfine grinding and then are matched according to a specific proportion. The preparation process comprises the steps of crushing; refining honey; and mixing and waking up the medicine. The traditional Chinese medicine composition has the following effects: the composition takes effect at multiple targets: up-regulating hair follicle survival promoting factors and down-regulating inflammatory mediators; the process has the advantages that the stability of pills is improved by controlling the viscosity of refined honey; the clinical application has the advantages that the cure rate of severe alopecia totalis is improved compared with the traditional prescription The recurrence rate is low after the medicine is stopped for one year. The formula is mainly used for treating alopecia, alopecia areata, sticktight and alopecia totalis.

The invention discloses application of a nutritional composition containing alpha-hydroxyisocaproic acid in weight management and blood fat improvement, and belongs to the fields of biological medicine manufacturing, biological medicine application and functional food development. The nutritional composition comprises alpha-hydroxyisocaproic acid and at least one second functional nutritional component, and the second functional nutritional component is preferably selected from one or more of the following components: 1) one or more of tea polyphenol and capsaicin; 2) one or more of beta-glucan, inulin and resistant dextrin; 3) one or more of medium chain triglyceride and sn-1, 3 diglyceride; under the condition of the same intake cycle and dosage, the nutritional composition can significantly improve the weight management effect and reduce related indexes of blood fat through a multi-way synergistic effect, and is combined with GLP-1 drugs or sequentially applied to weight management so as to reduce the risk of weight rise after drug withdrawal.

The invention discloses an application of a Gal-9 + Th cell and / or Gal-9 + Treg as an AIH detection target spot. Researches find that compared with a healthy control group, the peripheral blood Gal-9 + Treg cell proportion and Gal-9 + Th cell proportion of an AIH patient baseline group are remarkably increased, and after ALT of a patient in a treatment group returns to normal, the Gal-9 + Treg cell proportion and the Gal-9 + Th cell proportion are both decreased compared with those before treatment, and it is indicated that the Gal-9 + Treg cell proportion and the Gal-9 + Th cell proportion are effective indexes for monitoring disease improvement. However, the AIH is a chronic disease process, even if the ALT level returns to normal, Gal-9 + Treg cells and Gal-9 + Th cells still do not return to the level of a healthy control group, the Gal-9 + Th cells are taken as detection targets, the progress of the AIH disease course can be monitored more accurately, and disease repetition and biochemical rebounding caused by premature drug withdrawal are prevented.

The application discloses a synthesis method of N-chenodeoxycholyl-L-aspartic acid and application of the N-chenodeoxycholyl-L-aspartic acid in preparation of a medicine for improving metabolic associated fatty liver disease. The method provided by the application uses chenodeoxycholic acid and L-aspartic acid dimethyl ester hydrochloride as raw materials, synthesizes a chenodeoxycholic acid-aspartic acid dimethyl ester intermediate, and efficiently prepares a target compound, N-chenodeoxycholyl-L-aspartic acid, which is a novel structure, the compound exhibits a treatment effect superior to that of obeticholic acid (OCA) in an animal model, and can effectively improve multiple indexes such as liver steatosis, inflammation and fibrosis. The application provides a novel solution for major clinical challenges such as insufficient treatment effect, large side effect and rebound after drug withdrawal of current MAFLD treatment medicines, and provides a candidate compound with broad prospects for developing a new high-efficiency MAFLD treatment medicine.

The invention belongs to the technical field of biology, and relates to application of isovaleric acid in treatment of psoriasis. In order to solve the problems that existing psoriasis treatment drugs (such as biological agents) have side effects, the curative effect is reduced, and relapse occurs after drug withdrawal, the invention provides a psoriasis treatment scheme taking isovaleric acid as an active component, and the imiquimod-induced psoriasis-like skin lesion can be remarkably relieved by locally smearing the isovaleric acid with the concentration of 2mM; the epidermis excessive proliferation and the expression of inflammatory factors such as IL-17A, IL-17F and CXCL1 are reduced. The isovaleric acid disclosed by the invention is a small molecule compound, is simple to prepare, convenient to administrate and high in safety, fills the application blank of the isovaleric acid in the field of psoriasis treatment, and provides a new effective way for psoriasis treatment.

The present invention provides a medicine dispensing machine, including a cabinet, a medicine rack is arranged in the cabinet, a plurality of cargo lanes for storing medicines are arranged on the medicine rack, a medicine taking structure is arranged on the front side of the medicine rack, and a medicine loading structure is arranged on the rear side of the medicine rack; the medicine taking structure includes a first X-axis and a first Y-axis arranged on the front side of the medicine rack, the first Y-axis runs on the first X-axis, and a medicine taking mechanism is arranged on the first Y-axis; a medicine outlet is arranged on the side wall of the cabinet for discharging medicines taken out by the medicine taking mechanism; the medicine loading structure includes a second X-axis and a second Y-axis arranged on the rear side of the medicine rack, the second Y-axis runs on the second X-axis, and a medicine loading mechanism is arranged on the second Y-axis; the medicine loading mechanism includes a second mounting frame, a vertical plate and a lifting plate are arranged on the second mounting frame, the lifting plate is inclined downward to the vertical plate, and the lifting plate is driven by the lifting mechanism to move up and down. The side wall of the cabinet is provided with a medicine loading port for loading medicines to the medicine loading mechanism. The present invention can efficiently perform medicine taking and loading operations, and has a simple structural design and is easy to use.

The utility model relates to the technical field of dosing devices, and discloses a concentrated sulfuric acid dosing device which comprises a base, an intermediate tank is fixedly connected to the top of the base, a dosing mechanism is arranged on the surface of the intermediate tank, a protection mechanism is arranged on the top of the base, and the dosing mechanism comprises a medicine outlet. The medicine outlet is fixedly connected to the bottom of the right side of the intermediate tank, the rear end of the top of the intermediate tank is fixedly connected with a first connecting pipe, the top of the first connecting pipe is sleeved with a slipknot, a second connecting pipe is inserted into the slipknot, and the right end of the top of the second connecting pipe is fixedly connected with a medicine suction pipe; the intermediate tank can be conveniently treated and maintained by arranging the chemical adding mechanism, the probability of chemical leakage of the tank body can be greatly reduced, the connection between the storage tank and the chemical suction pipe can be easily cut off during maintenance after chemical stopping, very troublesome concentrated sulfuric acid does not need to be emptied for maintenance any more, and only a small part of concentrated sulfuric acid in a pipeline needs to be properly treated. And the safety and efficiency of device operation and maintenance are improved.

The invention belongs to the technical field of environment-friendly sewage treatment and automatic control, and particularly relates to a chemical phosphorus removal dosing control method and system. The method comprises the following steps: collecting data in a control period, modeling phosphorus removal capacity maintained by sludge and solid surface sediments after drug withdrawal or drug reduction as a phosphorus capacity state, online updating the phosphorus capacity according to a difference value between a drug feeding theoretical phosphorus removal amount and an actual phosphorus removal amount in combination with a sludge discharge amount, and establishing an effluent phosphorus prediction model taking the phosphorus capacity as input by utilizing regression. And constructing an optimization function containing the water outlet deviation and dosing, and solving the dosing amount under the dosing constraint to control the dosing pump. The phosphorus capacity memory effect is obviously introduced and estimated online, the contribution of the residual medicament can be objectively described, and the medicament utilization efficiency is improved, short-term excessive dosing is avoided, and the stability and robustness of effluent total phosphorus control are enhanced while effluent standard reaching, capacity safety redundancy and dosing stability are considered.

The invention discloses an application of a UFMylation regulator in preparation of a medicine for resisting HIV (Human Immunodeficiency Virus) infection. According to the application disclosed by the invention, through in-vivo and in-vitro pharmacodynamic experiments, the inhibition effect of a UFMylation regulator, namely a UFSP2 inhibitor Compond-8, on an HIV (Human Immunodeficiency Virus) is evaluated. Experimental results show that the Compound 8 can significantly inhibit the replication of MT-4 cells, primary CD4 + T cells and HIV viruses in mice, can still maintain low virus load after drug withdrawal, has no obvious influence on the proliferation of normal cells and the weight of mice, and has a good anti-HIV infection effect and high safety. The invention reveals that the Compound 8 effectively inhibits HIV-1 replication for the first time, prompts that the Compound 8 can be used as a candidate drug of an HIV-1 treatment drug, provides a new treatment strategy for AIDS, and has a wide application prospect in the field of HIV infection resistance.

The present invention discloses an intravenous push injection and flushing syringe, comprising a syringe and an integrated syringe push rod, wherein the integrated syringe push rod is arranged inside the syringe. The present invention enables injection and flushing to be completed at one time, does not require intermediate replacement of syringes, reduces complicated procedures such as replacement again, drug extraction, flushing, etc., and reduces the use of intravenous syringes by multiples, saves health resources, and reduces medical insurance expenditures. It has a simple structure, is easy to operate, reduces the workload of medical staff and saves labor time, and improves the safety and accuracy of intravenous medication.

The injection structure comprises an external structure and an injection push rod, a medicine cavity is formed in the external structure, and a medicine outlet is formed in the front end of the medicine cavity; the injection push rod is inserted into the medicine cavity in the front-back direction so that an injection cavity can be formed in the front end of the medicine cavity, and a liquid outlet groove cavity communicating with the outside is formed in the cavity wall, on the rear side of the injection cavity, of the medicine cavity. The injection push rod is provided with a medicine guide channel; one end of the medicine guide channel forms a medicine outlet opening at the front end of the injection push rod so as to be communicated with the injection cavity; when the injection push rod is located at the medicine pumping position, the medicine inlet is located at the position of the liquid outlet groove cavity to be communicated, and when the injection push rod moves forwards by a preset distance from the medicine pumping position to enter the injection position, the medicine inlet is blocked by the wall of the medicine cavity. The injection structure of the injector can effectively solve the problem that a medicine inlet and outlet system of an existing injection structure is complex. The utility model further discloses an injector comprising the injection structure.

The invention belongs to the field of biological medicine, and particularly relates to a method and a system for curative effect evaluation and drug withdrawal decision support of depression drugs. It has been found that the platelet 5-HT concentration can be used as an objective index of the curative effect of the antidepressant drug and drug withdrawal indication, a drug withdrawal decision-making system based on the platelet 5-HT concentration is constructed, and the platelet 5-HT concentration is combined with the blood concentration of the drug, the HAMD score of a depression patient and basic information of the depression patient. Compared with a conventional decision making system, the specific decision making formula designed by the invention can be used for realizing a more accurate drug withdrawal decision. In addition, a drug withdrawal decision-making system and a drug effect evaluation method based on the platelet 5-HT concentration are combined, and a complete depression drug effect evaluation and drug withdrawal decision-making system suitable for clinical application is developed.

The invention provides a drug rehabilitation traditional Chinese medicine composition. The drug rehabilitation traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 9.6 to 14.4 parts of American ginseng, 17.6 to 26.4 parts of astragalus membranaceus, 10.4 to 15.6 parts of bighead atractylodes rhizome, 10.4 to 15.6 parts of poria cocos, 8 to 12.5 parts of liquorice, 9.6 to 14.4 parts of angelica sinensis, 8 to 12.5 parts of rhizoma picrorhizae, 12 to 18 parts of honeysuckle, 8.8 to 13.2 parts of husks of millet, 8 to 12 parts of catechu, 10.4 to 15.6 parts of durac, 10.4 to 15.6 parts of radix rehmanniae, 10.4 to 15.6 parts of gentiana macrophylla, 10.4 to 15.6 parts of fructus alpiniae oxyphyllae and 17.6 to 26.4 parts of corydalis tuber. The invention further provides a preparation method, application and a quality detection method of the traditional Chinese medicine composition. Experiments prove that the traditional Chinese medicine composition is small in toxic and side effects, stable and controllable in curative effect and low in resorption rate, the acting point is that a large number of tonifying medicines are used for rescuing people firstly, and the symptom is treated by using the symptom-treating medicines, so that the body is recovered as soon as possible, and the treatment compliance of a user who eliminates the abstinence symptom is improved.

The invention relates to the technical field of traditional Chinese medicine compositions, and discloses a Chinese herbal medicine composition capable of repairing skin and a preparation method thereof, the Chinese herbal medicine composition comprises the following raw materials by weight: 8-15 parts of dahurian angelica root, 8-15 parts of giant typhonium rhizome, 20-40 parts of mung bean, 12-24 parts of Chinese pulsatilla root, 5-10 parts of gentian, 6-12 parts of cortex dictamni, 9-17 parts of common andrographis herb, 8-18 parts of corydalis tuber, 10-20 parts of catclaw buttercup root, 15-25 parts of Chinese lobelia, 3-10 parts of reed rhizome, and 12-24 parts of witch hazel. The problems of skin irritation, drug resistance, easy relapse after drug withdrawal, low patient compliance and the like in the existing western medicine treatment are solved.

The application provides a kind of cartilage polypeptide composition and its preparation method, the cartilage polypeptide 30-45%, auxiliary agent 10-25%, growth agent 3-8%, slow-release agent 2-9%, the balance is water, the application will cartilage polypeptide, auxiliary agent, growth agent and slow-release agent several ingredients scientific compatibility, preparation has the composition of protecting cartilage tissue, anti-inflammatory pain, effectively increase bone density effect, improve synovial tissue, there is no rebound ineffective condition after drug withdrawal.

The present invention relates to a traditional Chinese medicine composition, an oral liquid for treating rhinitis, and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following components in parts by weight: stir-fried Xanthii Fructus 10-45 parts, Magnoliae Flos 10-45 parts, Angelicae Dahuricae Radix 10-30 parts, Taraxaci Herba 10-35 parts, Gynostemmae Pentaphylli Herba 5-20 parts, Rhodiolae Roseae Radix 10-35 parts, Astragali Radix 10-30 parts, and stir-fried Atractylodis Macrocephalae Rhizoma 10-30 parts. The oral liquid prepared from the traditional Chinese medicine composition of the present invention can effectively treat mild and moderate rhinitis, has the effects of anti-allergy, immunosuppression, anti-inflammation and analgesia, has a relatively high total effective rate, and is not likely to relapse after drug withdrawal. At the same time, the present invention pays more attention to clearing and dispersing the lung qi, replenishing qi and strengthening the spleen, having supplementation in purgation, can regulate the body immunity, correct immune imbalance, and achieve the effect of treating both the symptoms and the root causes. The present invention has great medical value and broad application prospects in the field of treating rhinitis.

The invention discloses a traditional Chinese medicine composition for treating targeted drug related proteinuria, a pharmaceutical preparation and application. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials or extracts thereof: angelica sinensis, radix paeoniae alba, raw astragalus membranaceus, radix pseudostellariae, radix ophiopogonis, schisandra chinensis, raw atractylodes macrocephala koidz and divaricate saposhnikovia roots. The traditional Chinese medicine composition treats the anti-angiogenesis targeted drug related proteinuria through the treatment rules of activating blood and nourishing liver, and invigorating spleen and tonifying kidney, so that the patients can be treated by drugs, and the risk of drug withdrawal of the hepatocellular carcinoma patients due to the anti-angiogenesis targeted drug related proteinuria such as a vascular endothelial growth factor inhibitor is further reduced; the long-term prognosis of hepatocellular carcinoma patients is improved, and the lifetime of the hepatocellular carcinoma patients is prolonged.

The invention relates to the technical field of electronic atomization, in particular to a composition capable of improving strength, a liquid preparation and a preparation method and application thereof. According to the composition capable of improving the strength, provided by the invention, the composition capable of improving the strength is prepared from trigonelline, magnolol, pepper alcohol and tropine. According to the composition, specific substances are selected as raw material components of the composition capable of improving the strength, under the synergistic effect of the specific substances, the satisfaction of the nicotine-free liquid preparation is improved, and therefore the purpose of physiologically relieving addiction of a user is achieved.

The application discloses a traditional Chinese medicine composition for treating infantile constipation and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The application aims to solve the technical problems of general treatment effect, poor treatment durability, easy recurrence after drug withdrawal and safety risk in treating infantile constipation. The application provides a traditional Chinese medicine composition for treating infantile constipation, which comprises the following raw materials according to weight parts: 1-12 parts of hemp seeds, 2-10 parts of radish seeds, 1-10 parts of immature bitter oranges, 2-10 parts of Chinese plantain, 3-11 parts of rehmannia, 1-7 parts of honeysuckle and 1-9 parts of magnolia officinalis. The traditional Chinese medicine composition can be used for treating water deficiency and dryness constipation, and can improve the symptoms of infantile constipation through the mechanism of promoting gastrointestinal peristalsis.

The invention provides an intelligent management and control method and system for a medicine cabinet, and the method comprises the steps: obtaining the body detection data of a patient, the medicine preparation data of a doctor, the current residual medicine information, and the current medicine storage information of the medicine cabinet, and recognizing the target medicine use information of the patient based on the body detection data and the medicine preparation data of the doctor; through a medicine planning network, current medicine changing information of the patient is generated, and a medicine output storage strategy of the medicine cabinet is generated; collecting medicine return detection information of the patient based on the current medicine change information, and when the medicine return detection information meets the current medicine change condition, generating a medicine return control instruction and a medicine dispensing control instruction based on the medicine output storage strategy; and based on the medicine returning control instruction and the medicine dispensing control instruction, controlling the medicine cabinet to execute a medicine discharging storage task. By adopting the scheme, the intelligent management and control effect on the medicine cabinet can be improved.

The invention provides an application of a Jianjing bezoar heart-fire-clearing pill in treatment of a wide anxiety disorder, and discovers that the marketed drug Jianjing bezoar heart-fire-clearing pill can effectively treat the wide anxiety disorder. After the traditional Chinese medicine composition is continuously taken for 4 weeks, the average score of a Hamilton anxiety scale HAMA is reduced from 22.22 to 8.22 after 300 patients with general anxiety disorder are treated, and the total effective rate reaches 93%; the average score of a traditional Chinese medicine syndrome scale is reduced from 36.62 to 14.29, and the total effective rate reaches 96%; only 12 cases of adverse reactions are concentrated on the digestive system and are rapidly relieved after drug withdrawal. According to the invention, new indications of the Lianjing bezoar heart-fire-clearing pill are found, the application field of the Lianjing bezoar heart-fire-clearing pill is expanded, and the Lianjing bezoar heart-fire-clearing pill can also play a role in treatment of general anxiety disorder.

The invention discloses a traditional Chinese medicine composition for treating rheumatoid arthritis as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 70 to 130 parts of radix angelicae pubescentis, 70 to 130 parts of rhizoma seu radix notopterygii, 70 to 130 parts of radix stephaniae tetrandrae, 170 to 230 parts of herba siegesbeckiae, 130 to 170 parts of rhizoma atractylodis, 70 to 130 parts of cortex phellodendri, 170 to 230 parts of semen coicis, 70 to 130 parts of herba plantaginis, 70 to 130 parts of tetrapanax papyriferus, 70 to 130 parts of radix achyranthis bidentatae and 260 to 340 parts of ramulus mori. The traditional Chinese medicine composition can effectively solve the problems of large side effect, limited treatment effect and relapse after drug withdrawal of the existing medicine.

According to the medicine management and control system and the management and control method thereof, the empty bottle bin assembly is arranged, and meanwhile, the medicine return information input module and the empty bottle storage information input module are arranged at the host end; a data processing module is used for checking whether the medicine taking-out information is matched with the medicine returning information and the empty bottle storing information or not within a preset period, so that the whole medicine bottle using process is managed, controlled and traced, and warning information can be sent out. Besides, the name and the number of the medicine information are managed and controlled, monitoring of the valid period of the medicine is introduced, the medicine can be first-in and first-out in the management and control process, and the situation that part of the medicine is overdue due to long-time retention is avoided.

The application provides a traditional Chinese medicine compound microemulsion gel for treating atopic dermatitis and a preparation method, and belongs to the technical field of biological medicine. The traditional Chinese medicine compound microemulsion gel for treating atopic dermatitis comprises Wenqingyin microemulsion and a gel framework, the Wenqingyin microemulsion is loaded on the gel framework, and the gel framework is carbomer-940. The Wenqingyin microemulsion comprises 2.55% of oleic acid, 12.73% of castor oil polyoxyethylene ether, 12.73% of 1,2-pentanediol and 72% of an aqueous phase. The microemulsion gel comprises 3.5% of CP940, 10% of glycerol and 1% of triethanolamine. The traditional Chinese medicine compound for treating atopic dermatitis has remarkable effects and small side effects. The microemulsion gel has the advantages of convenient administration and drug withdrawal, avoidance of liver first-pass effect and reduction of gastrointestinal tract stimulation by being applied to the skin.

The application belongs to the field of biological medicine, and particularly relates to application of an extract of Pteronura dumerelli in preparation of a medicine for treating ulcerative colitis, and aims to solve the technical problems of weak mucosa repair capacity, high recurrence rate after drug withdrawal, prominent long-term application safety problem, poor drug response or drug resistance of part of patients, and poor economic accessibility of existing ulcerative colitis treatment medicines. The preparation of the extract comprises the following steps: edible soft tissues of Pteronura dumerelli are washed with clean water to remove impurities, and then subjected to tissue crushing and homogenization treatment in a preset low-temperature environment; a compound enzyme system composed of neutral protease and papain is added to perform mild limited enzymolysis, and active small-molecule peptides and polysaccharide components are reserved; after low-temperature centrifugation to remove precipitates, two-stage ultrafiltration membranes are used for grading purification, high-activity small-molecule anti-inflammatory repair components are enriched, and finally low-temperature vacuum concentration and sterile filtration are performed to obtain a light yellow water-soluble active extract. The extract can inhibit activation of a nuclear factor kappa B inflammatory pathway, down-regulate levels of tumor necrosis factor alpha, interleukin 6 and interleukin 1 beta proinflammatory factors, reduce intestinal inflammatory cascade reaction, up-regulate expression of tight junction proteins Occludin and Claudin-1, repair damaged intestinal epithelial barrier, promote ulcer mucosa regeneration and healing, and realize a double synergistic treatment effect of anti-inflammation and mucosa repair.

The invention belongs to the technical field of medicines, and particularly relates to a pharmaceutical composition for improving ovarian function damage and degeneration and a preparation method thereof. The corn-derived tetrapeptide LDYE is disclosed as a GnRH agonist for the first time, and the tetrapeptide LDYE is given while chemotherapy is performed on drugs such as CTX, so that damage of the CTX to ovarian functions can be reduced in the chemotherapy process, and the corn-derived tetrapeptide LDYE also has a protection effect on ovaries after drug withdrawal. The protective effect is reflected in the endocrine function and the reserve function of the ovary, and also reflected in that the preserved ovary reserve function can generate the outcome of pregnancy after chemotherapy, which shows that the protective effect on the fertility function of the ovary is also achieved.

The invention discloses a formula and a preparation method of a plaster for treating insomnia, and belongs to the technical field of traditional Chinese medicine transdermal delivery. Based on the traditional Chinese medicine dialectical theory, spina date seed, tuber fleeceflower stem and the like are used as monarch drugs for tranquilizing mind by nourishing the heart, poria cocos, bighead atractylodes rhizome and the like are used as ministerial drugs for strengthening the spleen and harmonizing the stomach, nacre mother of pearl, magnetite and the like are used as adjuvant drugs for calming the mind by heavy weight, and liquorice is used for regulating and promoting permeation, so that a basic formula and dialectical addition and subtraction system is formed, and the traditional Chinese medicine is adaptive to symptoms such as heart-spleen deficiency, hyperactivity of heart-liver fire and the like. The key process comprises the steps of mineral medicine nanometer calcination (the particle size is smaller than or equal to 50 nm, and the Fe dissolution rate is increased by 65%), alcohol-water double extraction and effective component enrichment, and preparation of an intelligent controlled-release matrix containing a chitosan-beta-cyclodextrin inclusion compound, and the transdermal rate is increased by 60%. The plaster is applied to acupoints such as Shenque and Xinshu, the functions of the braingut axis are improved by adjusting GABA / 5-HT neurotransmitters, multi-target synergistic effect is achieved, the total effective rate is 92.5%, the recurrence rate is 15% after one week of drug withdrawal, safety and no dependence are achieved, and an efficient and accurate external scheme is provided for insomnia treatment.

Examples described herein generally relate to recommending drug dosage reductions for a patient. A computer system may generate an initial non-linear glide path of recommended dosages starting at an initial dosage of a drug for a patient and ending at a goal dosage at an estimated time of arrival. The system may receive periodic patient monitoring including at least one drug withdrawal scale score, anxiety scale score, and indicated side effect. The system may determine, using one or more machine learning algorithms, a revised glide path based on a data record for the patient, the at least the drug withdrawal scale score and the at least one anxiety scale score for the patient. The system may recommend at least one medication or therapy for the indicated side effect. The system may determine a prescription adjustment based on the revised glide path.