Pharmaceutical composition using liensinine to work in coordination with doxorubicin for chemotherapy and application method of pharmaceutical composition

Abstract

The invention relates to a pharmaceutical composition using liensinine to work in coordination with doxorubicin for chemotherapy and an application method of the pharmaceutical composition. The pharmaceutical composition comprises a liensinine injection solution and a chemotherapy drug doxorubicin injection solution. The application method comprises the following steps: (1) performing intravenous injection of liensinine once daily according to the dose that actual dosage in the liensinine injection solution to the body weight of a patient is equal to 4.88mg / kg; (2) performing intravenous injection of doxorubicin once according to the dose that the actual dosage in the doxorubicin injection solution to the body weight of the patient is equal to 0.16mg / kg on the day of injecting liensinine according to the step (1); (3) performing intravenous injection of the doxorubicin injection solution once again according to the dose in the step (2) on the sixth day; and (4) determining whether to circulate according to the method of the steps (1)-(3) or not, the number of circulation times and the intermediate drug withdrawal time from the eleventh day according to the bearing capacity and the treatment effect of a patient body. Compared with the prior art, in the aspect of inhibiting and killing various malignant tumor cells, the pharmaceutical composition provided by the invention has the advantages of reducing the dosage, shortening the treatment period and reducing the occurrence of toxic and side reactions.

Description

technical field [0001] The present invention relates to the drug combination and specific application method of using other drugs in cooperation with doxorubicin when treating malignant tumors with chemotherapy. Background technique [0002] Chemotherapy is one of the methods for treating malignant tumors (cancer). It uses chemical drugs to prevent the proliferation, invasion, and metastasis of cancer cells, and finally kills cancer cells. Doxorubicin (Doxorubicin), also known as doxorubicin, is one of the chemotherapy drugs used in clinical practice, and its structural formula is: [0003] [0004] Doxorubicin injection (also known as injection) is used clinically. In the treatment of acute leukemia, malignant lymphoma, multiple myeloma, breast cancer, osteosarcoma, soft tissue sarcoma and lung cancer, it has a relatively significant effect. However, doxorubicin is the same as other chemotherapeutic drugs, due to its poor selectivity to tumor cells, it will inevitably ...

AI Technical Summary

Problems solved by technology

However, the drug combination itself cannot completely eliminate the problem of drug resistance, so people have been working hard to find more different drug combinations that can be replaced with each other

Regrettably, there are still relatively few drug combinations with doxorubicin as the main chemotherapy drug

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