843 results about "Injection solution" patented technology

The invention relates to the technical field of medical materials, in particular to an injection composition for endoscopic submucosal dissection and a preparation method and application thereof. The injection composition is prepared from the following raw materials: 1 to 5 w / v percent of sodium hydroxymethyl starch, 0.1 to 10 w / v percent of acetylcysteine, 0.2 to 4 w / v percent of polyvinylpyrrolidone, 0.001 to 0.1 w / v percent of coloring agent and the balance of phosphate buffer solution. The injection composition disclosed by the invention can be directly injected under mucous membranes, plays a role in upheaving diseased regions, has the advantages of long maintenance time and high upheaving degree, and has the effects of stopping bleeding and promoting wound healing.

A pen-type full-automatic precision injection system, comprising: a support table (1), an injection assembly (2), a connecting device (3), a control console (4), and a control switch (5). The control console (4) is arranged on the support table (1), the injection assembly (2) is connected to the control console (4) by means of the connecting device (3), and the control switch (5) can control the injection assembly (2) by means of the control console (4). The injection assembly (2) comprises an auxiliary positioning device (21), a housing (22), a drug storage device (23), a first movement assembly (24), and a second movement assembly (25). The auxiliary positioning device (21) is connected to a left wall of the housing (22). The first movement assembly (24) can drive an outer barrel (231) of the drug storage device (23) to move left and right, an injection needle (232) of the drug storage device (23) can penetrate through the housing (22) and the auxiliary positioning device (21) to pierce the skin of a human body, and the second movement assembly (25) can push a pushing rod (233) of the drug storage device (23) to move to push an injection liquid into the human body. The pen-type full-automatic precision injection system can achieve functions such as automatic injection, adjustment of the injection depth, precise control over the needle piercing depth, precise control over the injection dose, precise control over the injection rate, bubble detection, and pressure detection during injection.

The invention discloses a salt of ponabulin and application thereof, relates to the field of medicinal chemistry, and solves the problem that the curative effect is influenced by poor water solubility of ponabulin in the prior art. The invention provides a plurality of ponabulin salts, the salts are formed by ponabulin and inorganic acid or organic acid, and the structure of the ponabulin is shown as a formula I. The invention further provides a preparation method of the ponabulin salt. In addition, the invention finds that the solubility of p-toluenesulfonate and 1, 5-naphthalene disulfonate of ponabulin in water is remarkably improved by more than 2000 times compared with free alkali, so that the requirement that a solubilizer is not added or a few solubilizers are added in the injection preparation process can be met, and potential harm to human health in the long-term use process of the solubilizers can be prevented. Pharmacodynamic tests show that the salt of the ponabulin has good anti-tumor activity and an effect of relieving neutropenia, and is suitable for preparing anti-tumor drugs. # imgabs0 #

The invention provides a diphenhydramine hydrochloride injection and a preparation method thereof. According to the preparation method, the diphenhydramine hydrochloride injection with stable pH value, stable chemical property and sterility assurance level SAL less than or equal to 10 <-6 > can be obtained by controlling the material of a liquid medicine pipeline and the water resistance of a medium borosilicate glass ampoule. The diphenhydramine hydrochloride injection does not contain preservatives and cannot generate safety risks.

The invention belongs to the technical field of chemical medicine preparations, and particularly relates to a promethazine hydrochloride injection and a preparation method, the promethazine hydrochloride injection comprises the following components by weight concentration: 20-30 mg / mL of promethazine hydrochloride, 0.4-0.6 mg / mL of anhydrous sodium sulfite, 0.6-0.8 mg / mL of sodium pyrosulfite and 0.03-0.07 mg / mL of thioglycerol; the stability of the injection can be improved.

The invention belongs to the field of medicine, and relates to application of polydocanol in preparation of medicine for treating bromhidrosis through dispersion gridding subcutaneous multipoint continuous injection application, the polydocanol is a polydocanol injection, and each milliliter of the injection contains 5-30 mg of polydocanol. The invention further provides a medicine for treating bromhidrosis through dispersion gridding subcutaneous multipoint continuous injection application. The medicine comprises polydocanol and pharmaceutically acceptable auxiliary materials. The invention has the advantages of small trauma, simplicity and convenience in operation, high safety, longer treatment effect maintenance time and the like, and the long-term relieving effective rate is greater than 80%.

The invention belongs to the field of chemical medicine analysis, and particularly relates to a method for determining the content of impurities in phloroglucinol trimethyl ether. According to the method provided by the invention, the excessive methylation impurities (2, 4, 6-trimethoxytoluene, 2, 4, 6-trimethoxyxylene and 2, 4, 6-trimethoxytrimethylbenzene) generated in the methylation process can be detected, and the excessive methylation impurities are prevented from being further transferred and existing in a phloroglucinol trimethyl ether raw material medicine and a final product phloroglucinol injection preparation. Researches on specificity, accuracy, precision, limit of detection, limit of quantitation, linear range, durability and the like of the method prove that the method is suitable for measuring the content of the over-methylated impurities in the phloroglucinol trimethyl ether.

The invention belongs to the field of medicines, and particularly relates to a difloxacin microcrystal suspension injection which comprises water and a difloxacin crystal existing in the water in a suspension state. The particle size of the difloxacin crystal is 200 nm to 10 [mu] m, and the difloxacin crystal is of a sheet structure. The particle size of the difloxacin crystal in the difloxacin microcrystalline suspension injection provided by the invention is 200nm-10mu m, the difloxacin crystal is of a sheet structure, the crystal can stably exist in a liquid carrier in a suspension form, and after being prepared into the injection, the difloxacin microcrystalline suspension injection has the advantages of long acting time, small irritation and no blockage of a needle tube, and can be prepared into preparations with various concentrations. Meanwhile, the invention also provides a preparation method of the suspension injection.

The invention relates to the technical field of analytical chemistry, and particularly discloses an HPLC (High Performance Liquid Chromatography) detection method for related impurities in a vitamin B6 injection. The invention provides an HPLC detection method for related impurities in vitamin B6 injection. The HPLC detection method comprises the following steps: carrying out separation detection on a to-be-detected sample by adopting a chromatographic column taking octadecylsilane chemically bonded silica as a filler and a mobile phase gradient elution method; the mobile phase A is 0.04% sodium pentane sulfonate solution-methanol with the volume ratio of 95: 5, and the pH value of the 0.04% sodium pentane sulfonate solution is adjusted to 3.0 by adopting phosphoric acid; the mobile phase B is methanol. The HPLC detection method provided by the invention can detect 13 impurities in the vitamin B6 injection at the same time, the detection specificity is high, the sensitivity is high, the separation degree is good, and the quality of the vitamin B6 injection can be effectively controlled when the detection method is applied to production of the vitamin B6 injection.

The invention discloses a novel injection containing edaravone and high-purity synthesized (+)-2-borneol, because the (+)-2-borneol is prepared by a chemical synthesis process, the curative effect of the (+)-2-borneol is better than that of natural borneol and (+)-2-borneol extracted from the natural borneol under the same dosage, the toxic and side effects can be reduced, and the product quality is more stable; and the established GC-MS analysis method can more accurately control the content of each coexisting substance and better guarantee the shelf life quality. The injection is more suitable for improving the treatment effect on central nervous system diseases, oxidative stress injuries such as diabetes, retinopathy, diabetic peripheral neuropathy and neurodegenerative diseases and thrombus-related diseases.

The invention discloses an oxytetracycline injection and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the oxytetracycline is firstly micronized, then sprayed with water, frozen, heated and dried, soaked in a solution containing a surfactant, taken out and dried, and pretreated oxytetracycline is obtained; s2, water for injection is taken and heated, an antioxidant is added for dissolution, then a complexing agent is added, stirring is performed for dissolution, and a first solution is obtained; adding an organic solvent into the first solution, heating, adding the pretreated oxytetracycline, stirring and dissolving to obtain a second solution; adding a stabilizer into the second solution, and adjusting the pH value; and then supplementing the water for injection to obtain the injection. The oxytetracycline raw medicine powder is micronized to a specific particle size range, then freeze drying is performed to make the oxytetracycline raw medicine powder loose and porous, and compatibilization of the surfactant is further combined, so that the solubility and the stability of the oxytetracycline raw medicine powder are greatly improved in the subsequent injection preparation process.

The present invention provides an injectable liquid formulation comprising:a) a lipid controlled-release matrix comprising at least 50% triacyl lipids;b) at least one oxygen containing organic solvent;c) at least 16% by weight of at least one active agent selected from buprenorphine and salts thereof, calculated as buprenorphine free base. The invention further provides a controlled-release composition formed by administration of such an injectable liquid composition to a, preferably human, subject. The invention also provides a method of administration of buprenorphine to a subject comprising injecting such a liquid composition and a method for the treatment of pain, for opioid maintenance therapy or for the treatment of opioid dependence by detoxification and / or maintenance or for the treatment or prophylaxis of the symptoms of opioid withdrawal and / or cocaine withdrawal by injecting such a liquid composition.

The invention provides a silibinin mixed micelle injection as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The cholate / lecithin mixed micelle system constructed by adopting specific cholic acid and phospholipid has good stability, can be well compatible with the silibinin so as to well encapsulate the silibinin, can obviously improve the solubility of the silibinin, has higher safety under the condition of ensuring the stability of the silibinin, and can be used for preparing a medicine for treating the silibinin. Therefore, the bioavailability of the silibinin is greatly improved. According to the invention, a shearing dispersion method is adopted to prepare the mixed micelles, and the mixed micelles with high drug loading capacity, clarification and good stability for silibinin are formed by destroying and shearing the raw and auxiliary materials in a molecular level, so that the mixed micelles have better physical and chemical stability, the drug quality is easier to control, the process is more simplified, the clinical medication is safer and the cost is lower; and the accessibility of the medicine is improved.

The invention relates to the technical field of drug analysis and detection, and particularly discloses a method for detecting the residual quantity of glucose in an irinotecan hydrochloride liposome injection. According to the method, irinotecan hydrochloride in the liposome is fully separated from small molecular substances such as glucose and sodium chloride by adopting an ultrafiltration method, then, a Waters XBridge BEH HILIC chromatographic column is adopted, a mixed solution of an acetate buffer solution with the pH value of 3.8-4.2 and acetonitrile is used as a mobile phase, and the content of irinotecan hydrochloride in the liposome is detected in an isocratic elution mode by adopting a high performance liquid chromatography method. The effective separation of glucose, sodium chloride, 4-hydroxyethylpiperazine, sucrose octasulfate potassium and other substances is realized, and the condition of the glucose residue in the irinotecan hydrochloride liposome is accurately detected. The invention provides a reliable guarantee for improving and better controlling the quality of the irinotecan hydrochloride liposome injection product, and has very important significance for improving the medication safety.

The invention belongs to the technical field of medicines, and particularly relates to a posterior pituitary injection and a preparation method thereof. The posterior pituitary injection comprises the following raw materials in concentration: 6 units / ml of posterior pituitary powder, 1-5 mg / ml of trichlorobutanol and pharmaceutically acceptable acid, wherein the dosage of the pharmaceutically acceptable acid ensures that the pH value of the posterior pituitary injection is adjusted to 3.0-4.0. The invention further provides a preparation method of the posterior pituitary injection. According to the invention, the dissolving capacity of the auxiliary material trichlorobutyl alcohol in water can be improved, so that trichlorobutyl alcohol cannot be separated out under the condition of normal temperature or refrigeration. According to the invention, the quality of a medicinal preparation and the safety of medication can be better ensured, and the method has a good application prospect.

The invention discloses a pediatric compound amino acid injection and a preparation method thereof, and relates to the technical field of medicines. The invention relates to a preparation method of a pediatric compound amino acid injection. The preparation method comprises the following steps: carrying out vacuumizing and nitrogen charging treatment on a pipeline and a preparation tank for preparation; the preparation method comprises the following steps: adding low-oxygen injection water into a preparation tank, heating, continuously charging nitrogen, adding isoleucine, leucine, lysine acetate, methionine, phenylalanine, threonine, valine, histidine, tyrosine, acetyl tyrosine, alanine, arginine, proline, serine, glycine, aspartic acid and taurine, and stirring for dissolving; cooling the preparation tank, adding glacial acetic acid, then adding tryptophan, glutamic acid and cysteine hydrochloride, stirring and dissolving, adding the residual water for injection, and then adding glacial acetic acid to adjust the pH value to obtain a liquid medicine; carrying out intermediate determination on the liquid medicine, filtering, filling, and sealing; and carrying out hot-pressing sterilization on the sealed liquid medicine, and loading the sterilized liquid medicine and an oxygen absorbent into a barrier bag for vacuum packaging. The safety of the compound amino acid can be improved.

The invention provides a vitamin D3 liquid composition, the vitamin D3 liquid composition comprises vitamin D3 and polyethylene glycol-15-hydroxystearate, the pH value of the vitamin D3 liquid composition is 7.1-7.6, and the vitamin D3 liquid composition does not contain ethanol, propylene glycol, polyethylene glycol, poloxamer or polyvinylpyrrolidone. The aqueous solution composition is stable and uniform, is more suitable for injection compared with an oil solution, and can be used for preventing and treating vitamin D deficiency.

An injection device (10) comprises an injection solution receptacle (30) and a plunger (70) at feast a portion of which is slidably received in the injection solution receptacle (30), wherein the plunger (70) is displaceable relative to the injection solution receptacle (30) in a distal direction in order to expel an injection solution contained in the injection solution receptacle (30) from the injection solution receptacle (30). A first plunger stop mechanism (140) is adapted to stop a displacement of the plunger (70) relative to the injection solution receptacle (30) in the distal direction at a first dosing position (P1). A second plunger stop mechanism (140) is adapted to stop a displacement of the plunger (70) relative to the injection solution receptacle (30) from the first: dosing position (P1) in the distal direction at a second dosing position (P2), wherein the first and the second dosing position (P2) of the plunger (70) are selected in such a manner that the plunger (70), upon being displaced relative to the injection solution receptacle (30) between the first and the second dosing position (P2) is adapted to expel a desired dose of the injection solution contained in the injection solution receptacle (30) from the injection solution receptacle (30).

The invention discloses a terbinafine hydrochloride needleless injection, a transdermal injection for treating superficial fungal infection and an administration device of the transdermal injection, belongs to the technical field of pharmaceutical preparations, and successfully develops the terbinafine hydrochloride needleless injection which takes benzyl alcohol and ethanol as auxiliary materials, the invention provides a terbinafine hydrochloride needleless injection or an injection administration device thereof, which is used for preparing the terbinafine hydrochloride needleless injection, and proves that a prescription containing low-concentration ethanol can have good safety and excellent infiltration and absorption promoting capability, and the medicine can quickly reach a focus part and has long effective action time. The invention also provides the administration device of the terbinafine hydrochloride needleless injection or the injection thereof. According to the dosing device, the replaceable injection head and the injection assembly are used, cross infection can be reduced, and the purity of liquid medicine is kept.

The invention provides a preparation method of an edaravone and dextroborneol injection, the injection comprises edaravone, dextroborneol, propylene glycol and sodium pyrosulfite, in the preparation process, the propylene glycol accounting for 60%-85% of the prescription dosage and water accounting for 5%-25% of the prescription dosage are injected into a liquid preparation tank according to the volume ratio, the mixture is heated to 50-60 DEG C, edaravone is added and stirred to be dissolved, and the edaravone and dextroborneol injection is prepared. The preparation method comprises the following steps: dissolving propylene glycol in the remaining prescription dosage, adding dextroborneol which is dissolved by propylene glycol in the remaining prescription dosage in advance, uniformly stirring, adding water which is close to a constant volume, cooling to 25 DEG C or below, adding sodium pyrosulfite, adjusting the pH value to 4.0-5.0, and fixing the volume to a full volume. According to the preparation method of the edaravone dextroborneol injection, auxiliary materials in a specific proportion are matched with the preparation steps, the problem that raw material medicines are extremely easy to separate out in the preparation process is solved, the requirement of the preparation process for an industrial liquid preparation tank is low, industrial operation is convenient, and the preparation cost is low.

The invention mainly relates to a method for determining related substances of doxofylline injection, using high performance liquid chromatography, using octadecylsilane bonded silica gel as a filler; mobile phase A is a phosphoric acid aqueous solution with a pH of 1.5-3.5, and mobile phase B is acetonitrile, and gradient elution is performed. The detection method can completely separate impurities 1-9 in doxofylline injection, with a separation degree greater than 1.5, good system applicability, and the method has high specificity, accuracy and reproducibility, etc., is easy to operate, has no damage to the chromatographic column, and can be used for analysis, detection and quality control of doxofylline injection in industrial production.

The invention relates to the field of pharmacy, in particular to a chemical medicine injection. The present invention specifically discloses a phenylephrine hydrochloride injection and a preparation process thereof, the prescription of the phenylephrine hydrochloride injection comprises phenylephrine hydrochloride, sodium chloride, sodium pyrosulfite, an antioxidant 2, a sodium citrate dihydrate, a citric acid monohydrate and water for injection, the phenylephrine hydrochloride injection prepared by the optimized preparation process has the characteristics of simple components, small harm to human bodies, low impurity content, stable quality and safety.

The invention discloses a dexmedetomidine and propofol combined reagent and a combination method, and relates to the technical field of combined use of anesthetic drugs. According to the method, firstly, dexmedetomidine is subjected to intravenous pump injection within 5-15 minutes according to the dosage of 0.5-1.0 mu g / kg, propofol is given within 2 minutes after the dexmedetomidine is subjected to general anesthesia, and the dosage of the propofol can be reduced by 10%-50% compared with that of propofol which is independently used. Through pretreatment of dexmedetomidine, the anesthetic effect of propofol can be enhanced, adverse reactions such as blood pressure drop and respiratory depression can be effectively reduced, and anesthetic safety and controllability are improved. The combined reagent comprises independent containers for respectively loading the dexmedetomidine injection and the propofol emulsion, and can be packaged by adopting a double-cavity pre-filled injector, and sequential injection is realized through a controllable opening mechanism, so that unstable emulsification and titer change caused by physical mixing of medicines are avoided.

An anti-aging injection composition, an anti-aging injection, and use thereof. The anti-aging injection composition contains hyaluronic acid or a salt thereof, glycine, proline, lysine hydrochloride, and leucine, which can synergistically promote the generation of collagen and elastin in the skin, thereby helping to correct skin wrinkles, improve skin elasticity, and enhance skin radiance. The anti-aging injection composition can be used to prepare an anti-aging injection, which has the effect of resisting skin aging.

The invention provides a tigorasone fumarate injection and a preparation method thereof, and belongs to the technical field of medicines. The injection provided by the invention is prepared from tigorasone fumarate, a pH (Potential of Hydrogen) regulator and water for injection. The tegorasone fumarate injection has various medicine applications of inhibiting gastric acid secretion, promoting gastric ulcer healing and preventing reflux esophagitis. The injection can tolerate terminal sterilization, and is high in safety and good in stability.

The invention discloses an injection containing methoxyetomidate hydrochloride and a preparation method of the injection. The injection comprises the following components: methoxyetomidate hydrochloride, a pH regulator, a solubilizing stabilizer and a solvent. The preparation method of the injection is simple and convenient for commercial production. A stability result shows that the product has good stability and is convenient for clinical application.

The invention provides an urapidil hydrochloride injection and a preparation method thereof, and particularly relates to the field of medicines. The urapidil hydrochloride composition comprises the following components in w / v: 0.4-0.6% of urapidil hydrochloride; 9-11% of a stabilizer; 0.03 to 0.05 percent of anhydrous disodium hydrogen phosphate; 0.1-0.3% of sodium dihydrogen phosphate monohydrate, and the balance of water for injection, which is supplemented to 100%. The defects in the prior art are overcome, the cost is saved, meanwhile, the impurity level of the urapidil hydrochloride injection after sterilization is reduced, the liquid medicine temperature is reduced in the liquid preparation and filling processes, meanwhile, the inert gas is filled, the influence of metal ions in a production assembly is greatly reduced, and the production efficiency is improved. The levels of impurities C and D in the finished product after the urapidil hydrochloride injection is sterilized are reduced; the prepared urapidil hydrochloride injection is low in impurity level and high in stability, the quality of the urapidil hydrochloride injection meets the requirements of current laws and regulations, and the urapidil hydrochloride injection is superior to a reference preparation.

The present invention discloses an N-acetylcysteine xylitol injection and its preparation method, which comprises raw materials with the following mass-volume ratios: 0.020 - 0.035 g / mL of N-acetylcysteine, 0.015 - 0.030 g / mL of xylitol, 0.005 - 0.010 g / mL of pH regulator, and the balance being injection water. The method of the present invention can reduce the oxidation and degradation of N-acetylcysteine during the preparation of the medicinal solution by controlling the dissolution concentration, temperature and range of the residual headspace oxygen amount of N-acetylcysteine, and selecting a pH regulator with an appropriate concentration to control the pH value of the medicinal solution and controlling the preparation time, thereby improving the stability of the product quality and controlling the generation of related substances. The present invention significantly improves the quality stability of the N-acetylcysteine xylitol injection, ensures the safety of patients' medication, and makes the product have broad application prospects and value.

The invention provides a method for improving product quality by optimizing a posterior pituitary injection purification process, and belongs to the technical field of medicines. According to the method, glacial acetic acid is adopted as a dissolving medium, and the influence of the concentration of glacial acetic acid, the extraction temperature and the filtering condition on the posterior pituitary injection is investigated, so that visible foreign matters and macromolecular substances are effectively removed, and the potency, the specific activity and the potency ratio of the product are improved. Besides, the method is simple to operate, ensures the stability and curative effect of the product, is suitable for industrial production of the posterior pituitary injection, and has important significance for improving the drug quality and meeting clinical requirements.

The invention discloses a preparation method of a famotidine injection. The preparation method of the famotidine injection provided by the invention comprises the following steps: injecting water for injection into a liquid preparation tank, and then sequentially adding nicotinamide, lactic acid hydrolysate, famotidine, mannitol and vitamin C according to a prescription dosage to obtain a feed liquid; adjusting the pH value of the feed liquid to 5.8-6.2, and fixing the volume; sterilizing, filtering and encapsulating the feed liquid; the preparation method is carried out under full-scale nitrogen charging protection, and in the liquid preparation process, the headspace residual oxygen content is controlled to be smaller than or equal to 0.5%, the liquid preparation temperature is controlled to be smaller than or equal to 25 DEG C, the dissolved oxygen content of liquid medicine is controlled to be smaller than or equal to 0.6 mg / L, and the headspace residual oxygen content of a finished product is controlled to be smaller than or equal to 1.2%. Under the condition of adopting the same raw and auxiliary materials and proportion as the original research medicine preparation, by strictly controlling the operation conditions in the large-scale preparation process, the content of related substances in the injection can be remarkably reduced, the impurity level can be reduced, and meanwhile, the long-term stability of the injection can be remarkably improved.