Oxiracetam injection

A technology for injection and water for injection, which is applied in the fields of drug delivery, cardiovascular system diseases, organic active ingredients, etc. It can solve the problem of lower solubility of oxiracetam, and achieve good storage stability and stable quality
CN101396358AActive Publication Date: 2009-04-01广东世信药业有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
广东世信药业有限公司
Publication Date
2009-04-01

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Abstract

The invention relates to an oxiracetam injection solution which comprises 1 weight portion of oxiracetam, 1.5 to 5.5 weight portions of glucose and 50 to 100 weight portions of injection water, wherein, the pH value of the injection solution is 3.8 to 4.5. The invention also provides a preparation method of the oxiracetam injection solution which comprises the steps as follows: a) the bulk drug oxiracetam and the glucose or sodium chloride are solved in the injection water under the temperature of 40 DEG C to 70 DEG C to obtain dissolved solution; b) the dissolved solution is cooled to the room temperature, active carbon is added for decolorizing, the active carbon is removed by filtering, proper quantity of water is complemented, and citric acid and sodium citrate are added to adjust the pH value to 3.8 to 4.5 to obtain the dissolved solution with adjusted pH value; c) an intermediate product after encapsulation is sterilized; and d) the product after the sterilization is packed. The oxiracetam injection solution manufactured by the prescription and the preparation method of the invention has good storage stability.
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Description

technical field

[0001] The invention relates to pharmaceutical preparations, more specifically to oxiracetam injection, a medicine for treating brain damage. technical background

[0002] Oxiracetam is a new generation of brain metabolism improving drug with the following structure:

[0003]

[0004] The chemical name is: 4-hydroxy-2-oxo-1-pyrrole acetamide, which is a new type of pyrrolidone (cyclic GABOB) derivative. It has a good curative effect on cerebrovascular disease, brain injury, brain tumor (postoperative), intracranial infection, dementia, and brain degenerative diseases. This product selectively acts on the cerebral cortex, stimulates specific neural pathways in the hippocampus, activates, protects and repairs brain nerve cells, but has no central sedative or exciting effect. Oxiracetam is safe and well tolerated by patients.

[0005] Oxiracetam has a wide range of clinical indications. Mainly to promote the recovery of comatose patients after neurosurger...

Claims

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