49 results about "Intracranial infection" patented technology

The invention belongs to the field of regenerative medicine materials, and in particular relates to an antibacterial cation-modified absorbable pachymeninx repair material and a preparation method and application thereof. The antibacterial cation-modified absorbable pachymeninx repair material is of a double-layer structure consisting of a degradable polyester nanofiber membrane modified by epsilon-polylysine and a three-dimensional porous high-molecular material. The absorbable pachymeninx repair material provided by the invention has excellent antibacterial characteristic, can effectively prevent postoperative intracranial infection, and can be directly attached and sewed for use; product compositions and a preparation process are simple, and industrial production are easily realized. The antibacterial cation-modified absorbable pachymeninx repair material of the invention is a novel medical biological material which is novel in structure and excellent in performance, and presents a good application prospect in the field of pachymeninx defect repair.

The invention relates to a traditional Chinese medicinal preparation for treating febrile convulsion and a preparation method of the Chinese medicinal preparation. The effective components of the traditional Chinese medicinal preparation comprise the following raw materials: serissa serissoides, ox-gall, rhizoma calami, manyleaf paris rhizome, cryptotympana atrata fabricius, drymotaenium miyoshianum, buta graveolens, white gourd, phymatopteris crenatopinnata, lotus, pinkflush rhododendron root, radix prismatomeris connatae, red-spotted stonecrop, elaeagnus conferta roxb, birch bark and loquat. The traditional Chinese medicinal preparation is appropriate in medicinal material compatibility, accords with traditional Chinese medical and modern medical theories, has the effects of tonifying the spleen and kidney, expelling wind and clearing heat, relieving convulsion and spasm, clearing heart and inducing resuscitation, has remarkable effect on treating febrile convulsion caused by intracranial infection, encephalopathia toxica, epilepsy, cerebral parasitic disease, hypertensive encephalopathy, poisoning, brain tumor and the like, has the advantages of short course of treatment, high safety and no toxic or side effect, is in favor of reducing the syndrome of an infected child in time, and has the effect of preventing relapse after febrile convulsion is healed.

The invention discloses a device used for airtight lumbar puncturing and cerebrospinal fluid replacing. The device comprises a lumbar puncture needle, an injector and a connector used for connecting the lumbar puncture needle and the injector. A communicating device with four communicating pipes is arranged in the connector. The device has the advantages that functions are multiple, use is safe and convenient, the device is used for the lumbar puncturing and is good in airtightness and sterile, direction dividing operation can be achieved, the risk of intracranial infection caused by lumbar puncturing and intrathecal liquid injecting can be effectively avoided, the flow speed of the cerebrospinal fluid can be controlled, the risk of the formation of cerebral hernia can be avoided, intrathecal liquid injecting can be conducted through a side hole in the device and the injector, different medicine can be injected, the flow speed of liquid medicine can be controlled through a valve, the pressure in the medicine injecting process can be controlled through a pressure regulating valve, and intrathecal liquid injecting can be reasonably and safety conducted.

The invention provides an absorbable anastomosis lock nail and a lock nail holder. The anastomosis lock nail is used for repairing sella or basis cranii cerebral dura mater when treating sella lesion via a nasal transsphenoidal approach in neurosurgery or when used for neuroendoscopic surgery. The absorbable anastomosis lock nail comprises a lock head and a lock cap, the head end of the lock head is a three-rhombohedral-surface structure, a raised stopping portion is arranged on the inner wall of the lock cap, and the lock head penetrates through the stopping portion to be fixedly clamped in the lock cap when locking. The structure of the head end of the nail holder corresponds to the structure of the anastomosis lock nail, and the nail holder is provided with fixing grooves corresponding to the lock head and the lock cap. By the aid of the absorbable anastomosis lock nail, artificial cerebral dura mater or autologous fascia and an incised dura mater residual edge of the skull base of a patient can be completely repaired, various complications including cerebrospinal fluid, intracranial infection and the like which are caused by a present traditional method of filling biological glue and various filling materials into sella and sphenoid sinus are obviously reduced, and simultaneously, death rate caused by the complications is reduced.

The invention discloses a pressure monitoring and adjusting device for an external drainage system. The pressure monitoring and adjusting device has the advantages that intracranial pressure data of apatient are detected by a detection device and transmitted to a controller, the controller transmits the intracranial pressure data to a display screen for display, so that a doctor can acquire the current intracranial pressure of a patient in real time, and determination of a therapeutic schedule of medical staff and therapy are accelerated. Besides, the acquired intracranial pressure of the patient is compared with intracranial pressure and intracranial pressure adjusting bottle relative adjustment height data in a database by the controller, an intracranial pressure adjusting bottle is adjusted to a corresponding height, a lifting device is driven by a lead screw, the lifting process is stable, and intracranial infection of the patient caused by lifting instability of the intracranialpressure adjusting bottle is avoided. When the intracranial pressure adjusting bottle rises to be abutted to a lead screw fixing plate, the abutting detection device generates abutting signals and transmits the abutting signals to the controller, the controller outputs alarm signals and the intracranial pressure data to an external hospital duty room, and an operator on duty timely finds and handles the abnormal condition of the patient.

A drainage device for intracranial hematoma cranium drilling is characterized by comprising a double-cavity catheter, a drainage tube, a dredging balloon, a drainage bag and a reverse flowing prevention tee joint. The double-cavity catheter is provided with a first tube cavity and a second tube cavity, wherein the first tube cavity and the second tube cavity are mutually isolated, the first tube cavity is used for drainage and connected with the drainage tube, and the second tube cavity is used for medicine injection and flushing and connected with an injection tube. The double-cavity catheter is arranged, so that drainage, flushing, and medicine injection are performed in different channels, it is guaranteed that the channels are kept sanitary and clean, and intracranial infection is prevented. The reverse flowing prevention tee joint is used for preventing hydrops from flowing reversely so that secondary infection and danger can be prevented. Scales are arranged on the drainage tube and the drainage bag, the dredging balloon is connected with an air pressure adjusting assembly, and the scales and the air pressure adjusting assembly are arranged, so that it is avoided that the operation force can not be mastered due to insufficient experience, and operation stability is improved. In addition, the drainage device is further provided with a dropping bottle and the dredging balloon, so that the channels are convenient to observe and prevented from being blocked.

The invention discloses a Chinese herba preparation for treating heat toxin stasis type hydrocephalus for children. Most of patients suffering from heat toxin stasis type hydrocephalus suffer from intracranial infection and in vivo hot toxin stasis to cause that organ qi can not descend, qi function is easy to stagnate, and comfortable in running; because the head is the confluence of all yang-channels, the diseases are caused by heat toxin interference, hot toxin stasis, and swelling caused predominant heat. According to the Chinese herba preparation, Chinese medicinal herbs such as radix semiaquilegiae, yunnan dysosma tuber, littleleaf indianmulberry root and stem, urena lobata, herb of jamaica falsevalerian, cyrtomium fortunei, rhizoma anemones altaicae, calamus, adiantum soboliferum, and Chinese elm bark which have the functions of clearing away heat and toxic materials, inducing resuscitation, dredging collaterals and promoting diuresis, and are decocted with water to obtain a decoction. Through clinical tests in our hospital, the total effective rate is 97.8 percent. Patients have no remarkable untoward effects in a treatment course.

The invention relates to a traditional Chinese medicinal extract product prepared from traditional Chinese medicinal raw materials composed of root of large-flowered skullcap, cape jasmine and pseudo-ginseng, a traditional Chinese medicinal composition containing scutelloside, geniposide and panax notoginseng saponins, a medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition, and their clinical application. The traditional Chinese medicinal extract product, the traditional Chinese medicinal composition and the medicine containing the traditional Chinese medicinal extract product or the traditional Chinese medicinal composition can be used in emergency treatment and treatment of diseases such as cerebrovascular disease, intracranial infection, craniocerebral trauma, craniocerebral space-occupying lesion or intoxication and the like, which are mainly represented by brain edema.

The invention provides a method for rapid detection of postoperative intracranial bacterial infection by multiple real-time fluorescent PCR (Polymerase Chain Reaction) and belongs to the technical field of molecular biology. The method adopts a multiple fluorescent PCR technology to detect the cerebrospinal fluid of a patient with intracranial surgery fever so as to realize the typing detection ofa plurality of common intracranial infection bacteria. The method provided by the invention can realize rapid detection of postoperative intracranial bacterial infection, can quickly identify commonbacterial types in patients with intracranial infection after surgery, and solves the problems that a culture method can not identify new strains and can not culture bacteria. The detection method hashigh specificity and sensitivity, reduces the false positive of PCR detection, shortens the detection period, can realize timely and rapid diagnosis of intracranial bacterial infection, and has significant significance for blocking clinical infection and guiding medication.

An in-vitro simulated ventricular system device comprises an external bag, an internal water bag, a first pipeline, a second pipeline and an external controller. The internal water bag is arranged in the external bag. A pressure sensor is arranged on the inner wall of the external bag. One end of the first pipeline penetrates the external bag from the upper side to be communicated with the internal water bag. An upper valve is mounted on the first pipeline. The other end of the second pipeline penetrates the external bag from the lower side to be communicated with the internal water bag. A lower valve is mounted on the second pipeline. The external controller is connected with the upper valve, the lower valve and the pressure sensor. The in-vitro simulated ventricular system device has the advantages that the device is simple in structure, reliable to use and capable of monitoring pressure of encephalic ventricular systems of patients in real time and adjusting drainage in vitro according to pressure change; by the device, direct contact between the pressure sensor and cerebrospinal fluids is avoided, and intracranial infection risks are reduced.

The invention provides a blood brain barrier-crossing magnetic nano drug carrier and a preparation method thereof, and relates to the technical field of drug carriers; the blood brain barrier-crossingmagnetic nano drug carrier includes mesoporous silica, the interior of the mesoporous silica is provided with a paramagnetic substance, and the outer surface of the mesoporous silica is coated with adouble-sensitive copolymer-liposome; the technical problems that intracranial infection is easy to cause and long-term drug use is not facilitated because main paths to send a drug into a brain comprise intracerebral intubation, ventricular injection and other neurosurgery department methods at present are relieved; the blood brain barrier-crossing magnetic nano drug carrier is prepared, whereinthe blood brain barrier-crossing magnetic nano drug carrier integrates magnetic targeting and pH with heat sensitivity, can carry a drug under the guidance of an external magnetic field, crosses a blood brain barrier to directly reach a lesion site and controllably releases the drug, and the technical effect capable of effectively treating central nervous system diseases is achieved.

The invention relates to a drainage pipe. The drainage pipe comprises a first drainage pipe, a second drainage pipe and a pressure-resistant strip, wherein the first drainage pipe comprises a first drainage cavity, the second drainage pipe comprises a second drainage cavity, and the first drainage cavity is not communicated with the second drainage cavity; the first drainage pipe comprises a first inserting section and a first main body section, the second drainage pipe comprises a second inserting section and a second main body section; a plurality of lateral holes are evenly distributed in the first inserting section and the second inserting section; the main body section of the first drainage pipe and the main body section of the second drainage pipe are integrated; the pressure-resistant strip is located between the main body section of the first drainage pipe and the main body section of the second drainage pipe. The drainage pipe can carry out drainage simultaneously on an interval outside a hard film and an interval under the hard film, will not bend partially in the drainage process, is smooth in the drainage process, is easy to operate and largely reduces the possibility that a patient has an intracranial infection.

The invention discloses a clinical drainage device for neurosurgery. The clinical drainage device for the neurosurgery comprises a support disc, wherein a drainage tank is arranged on the upper surface of the support disc; an injection liquid tank is arranged on one side of the drainage tank; the top of the injection liquid tank is connected with an injection guide tube; the other end of the injection guide tube is connected with a transfusion device; the transfusion device is connected with an injection tube; the top of the drainage tank is connected with a drainage tube; the other end of the drainage tube is connected with a three-way joint; the left side of the three-way joint is connected with a first drainage branch tube; the right side of the three-way joint is connected with a second drainage branch tube; the lower surface of the support disc is fixedly connected with a chassis through an electric telescopic rod. The clinical drainage device for the neurosurgery is simple and reasonable in structure and convenient to use and is capable of achieving drainage of different parts; through cooperation of the transfusion device and the injection tube, medicines such as hemolytic agents or antibiotics and the like can be conveniently injected; the intracranial infection is avoided; the safety is improved; the whole device is easy to control and convenient to operate.

The invention discloses a modified bacterial cellulose composite scaffold material for umbilical cord MSCs and a preparation method thereof, and belongs to the field of stem cell transplantation and the field of bacterial cellulose composite scaffold materials. According to the technical scheme, the modified bacterial cellulose composite scaffold material comprises a modified bacterial cellulose composite membrane and the umbilical cord MSCs which are implanted on the modified bacterial cellulose composite membrane. The preparation method comprises the steps that neonatal umbilical cord Wharton's jelly is cultured through an MSCs culture medium to obtain P3 umbilical cord MSCs; after freeze-drying, the physical properties of the composite membrane are determined. According to the preparation method, the bacterial cellulose composite membrane can be used as a scaffold to which the mesenchymal stem cells are attached, during cerebral injury local transplantation, the effect that the mesenchymal stem cells promote neural functional recovery is fully exerted, and the problem about the way how the stem cells are transplanted efficiently is solved; the modified bacterial cellulose composite scaffold material can replace an artificial meningeal patch to recover defective cerebral dura mater, the meningeal integrity is reconstructed, brain tissue is protected, and leakage of cerebrospinal fluid, intracranial infection, encephalocele, epilepsy and other complications are prevented.

The invention relates to the technical field of medical instruments, in particular to a drainage device for neurosurgery operation. The drainage device comprises a negative pressure suction mechanism and an intracranial pressure stabilizing mechanism, wherein the intracranial pressure stabilizing mechanism comprises a shell, and an intracranial pressure detection device, a liquid supply assembly and a controller which are positioned in the shell; the intracranial pressure detection device is connected with a detection probe through a wire; the liquid supply assembly comprises an antibiotic normal saline storage bottle, an electric valve is arranged at a liquid outlet of the antibiotic normal saline storage bottle, an infusion catheter is connected to the output end of the electric valve, and an annular spray head is fixedly arranged at the end, away from the electric valve, of the infusion catheter; and the input end of a controller is electrically connected with the detection probe, and the output end of the controller is electrically connected with the electric valve. The cranial cavity is flushed through antibiotic normal saline, postoperative cranial cavity pneumatosis is effectively avoided, intracranial infection is effectively controlled, the intracranial pressure of a patient can be detected while the drainage task is completed, and the device is safe, reliable, easy to operate and low in manufacturing cost.

The invention provides a color-changing visible wound dressing. The dressing is of a flat structure, and the longitudinal section structure of the dressing sequentially comprises at least four layersof structures from outside to inside, namely an exogenous substance color-changing layer, a transparent layer, an endogenous substance color-changing layer and a dressing inner layer. The wound dressing is particularly suitable for postoperative wounds after lumbar cistern drainage, a wound pollution condition can be reflected more visually, wound dressing pollutant sources (cerebrospinal fluid, urine, sweat and the like) can be found as soon as possible, family members of patients or nurses can find pollution in time and treat the pollutant sources in time, intracranial infection risks are reduced, and the risk of complications of the patients is greatly reduced.

The invention relates to an intracerebral signal acquisition device, a preparation method thereof and a brain-computer interface. The intracerebral signal acquisition device comprises a biological silk protein substrate, a brain electrode, a first biological silk protein insulating layer, an intracranial information acquisition layer and a biological silk protein packaging layer, wherein the brainelectrode is positioned on the biological silk protein substrate and used for acquiring an electroencephalogram signal; the first biological silk protein insulating layer is positioned on the brain electrode; the intracranial information acquisition layer is positioned on the first biological silk protein insulating layer and used for acquiring intracranial temperature and intracranial pressure;and the biological silk protein packaging layer is positioned on the intracranial information acquisition layer. The intracerebral signal acquisition device has the advantages of multiple functions, capability of being implanted and degraded in vivo, capability of stably recording in vivo for a long time, high temporal-spatial resolution and the like, and can acquire the electroencephalogram signal and intracranial information, so that the problems of intracranial hemorrhage, intracranial infection and the like can be monitored in real time.

The invention discloses an ultrasonic-based awakening promoting system. The ultrasonic-based awakening promoting system comprises a target point treatment instrument, wherein the target point treatment instrument comprises an ultrasonic pulse transmission unit, a transducer unit and a fixing device, and the ultrasonic pulse transmission unit is composed of a pulse generator and a power amplifier.According to the ultrasonic-based awakening promoting system, the employed treatment method is a pure-physical treatment method and is convenient in operation, good in treatment effect, high in safetyand easy to implement, risks such as intracranial infection are minimized, the condition that a sufferer suffering from conscious disturbance recovers consciousness as soon as possible can be promoted so as to alleviate sufferings and economic burden of the sufferer, and thus, an efficient, safe and high-cost-performance awakening promoting method is provided for clinicians; and different ultrasonic parameters including pulse repetition frequency, pulse duration, fundamental frequency, fundamental numbers and pulse numbers can be employed according to general conditions, disease situation seriousness, stimulated regions and effects of stimulation of sufferers, and customized treatment suitable for the sufferers can be provided according to tissue conditions of target point regions.

The invention relates to a transnasal nerve skull base repair device, a skull base repair membrane and a using method of the device. The transnasal nerve skull base repair device comprises a first repair membrane assembly used for repairing a liliequist membrane ventage and a second repair membrane assembly used for repairing a dura mater ventage. According to the transnasal nerve skull base repairing device, the skull base repairing membrane and the using method of the device, through cooperative use of the fusible biological membrane, the non-fusible biological membrane, the supporting piece, the hemostatic yarn and the fixing air bag, the technical scheme is compact in structure, high in clinical practicability and remarkable in effect; the skull base repair is successfully realized, the occurrence of postoperative complication cerebrospinal fluid leakage of the transnasal neuroendoscopy is prevented, the risk of intracranial infection is reduced, the possibility of endangering the life of a patient is reduced, the life quality of the patient is improved, and the prognosis is improved; in addition, artificial materials are adopted in the repairing process of the method.

The invention discloses an intracranial pressure monitor. The intracranial pressure monitor comprises a signal detection receiving mechanism and an analysis detection mechanism in communication connection with the signal detection receiving mechanism, wherein the signal detection receiving mechanism comprises a detection light source; a first light-shielding patch is arranged on the head of a patient and used for receiving a first light signal transmitted by the detection light source and transmitting the first light signal into the cranium of the patient; a second light-shielding patch is arranged on the head of the patient and used for receiving a second light signal which is emitted from the cranium of the patient after the first light signal is transmitted into the cranium of the patient and transmitting the second light signal to a detection probe; the detection probe is used for receiving the second light signal transmitted by the second light-shielding patch and transmitting the transmitted second light signal to the analysis detection mechanism; and the analysis detection mechanism is used for receiving the second light signal transmitted by the detection probe and processing the second light signal to obtain intracranial pressure data. The invention further discloses an intracranial pressure monitoring method. The intracranial pressure monitor and the intracranial pressure monitoring method aim at obtaining intracranial pressure through noninvasive monitoring so as to avoid intracranial infection.

The invention discloses an intracranial infection sampling device for neurology department, and relates to the technical field of medical instruments, the intracranial infection sampling device comprises a device shell and a sampling needle tube, a vertical rotating column is rotatably mounted on the inner wall of the top of the device shell, a placing disc is mounted at the bottom end of the vertical rotating column, and a plurality of test tube grooves are uniformly formed in the top of the placing disc. Through the arrangement of the intermittent driving assembly, the vertical rotating column and the placing disc can be driven to intermittently rotate, so that a test tube intermittently rotates to the position under the sampling barrel to receive a sample, meanwhile, the equivalent sampling assembly can drive a negative pressure piston to reciprocate up and down in the sampling barrel, and when the negative pressure piston moves upwards, the test tube can be taken out. When the negative pressure piston moves downwards, the extracted infections can be extruded into the test tube under the negative pressure piston, so that the purposes of automatic sampling and subpackaging can be achieved, subpackaged samples are equal and uniform in quantity, time and labor are saved, and the practicability is improved.