The present invention provides a set of internal fixing surgical instruments for minimally invasive lumbosacral anterior fusion operation, including a series of components of a positioning channel, a guide pin, a main channel, a drilling head, an intervertebral processor with a self-adjusting rotary cutter head, a water-injection style intervertebral cleaner, a thick wall channel sleeve, a fixing channel, a fixing screw, a screw fastening device, a screw end cap, an end cap fastening device etc.; in view of the abnormal function of the intervertebral structure, intervertebral instability, nerve root involvement and other lesions of the lumber vertebra section caused by lumbar intervertebral DDD, the application of the instruments can reduce the injuries and damages to the adjacent soft tissues and the spine stable structure to the maximum extend based on the smooth completion of the surgical operations of disc excision, intervertebral space processing, intervertebral space expansion, intervertebral fusion, internal fixation and so on, at the same time, the present invention can also reduce the postoperative complications, shorten the hospital stay and reduce the hospitalization cost to the maximum extend, thereby improving the operation effects and the satisfaction to the maximum extend.