296 results about "Necrosis" patented technology

The invention discloses a hepatocellular carcinoma pathological micro-necrosis recognition system and method based on federal continuous learning. The method comprises the following steps: firstly, obtaining time sequence image data of a multi-center full-size hepatocellular carcinoma tumor pathological section; performing foreground segmentation on the image data, removing a non-tumor background region, and generating a classification task-oriented standardized image block group; then, after each round of training is completed, the local model weight of each center is uploaded to a server, the server calculates the global weight according to the data scale of each center by adopting a weighted average strategy based on the data sample size, and the global weight is distributed to all participating centers for model iteration; a timing sequence sensitive regularization constraint is designed, and the weight updating strength of local training of each center is dynamically adjusted; and finally, comprehensively calculating the cross entropy loss and the proportion label fitting loss of the image block classification task, and the regular term loss in the model iteration process.

The invention relates to the technical field of image segmentation, in particular to a medical image processing method for tumor partition recognition, which comprises the following steps: acquiring a multi-modal medical image, extracting gray features and adjusting image gray, recognizing tissue boundary and metabolism features, grouping and generating tumor boundary response partitions, extracting heterogeneous nodes and classifying and labeling. Dividing a core area, an infiltration area and a necrosis area, and generating a tumor functional structure chart. According to the method, the gray frequency and the edge trend of the multi-modal image are unified, the structure contrast is enhanced, the consistency of each modal image in space and gray level is ensured, the information fusion integrity is improved, the gray, texture and metabolism characteristics are combined, the density mutation and metabolism enhancement region is identified, and the boundary clear contour is constructed; boundary partitions are established through response direction consistency, the cross-modal discrimination ability is enhanced, texture and metabolic characteristics are fused to classify heterogeneous nodes, a core area, an infiltration area and a necrosis area are divided, and functional partitions with clear expression and clear structures are generated.

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

The utility model relates to a self-adaptive pressure tourniquet which comprises a fixing band body, the unfolding face of the fixing band body is in a sector shape with the upper portion wide and the lower portion narrow, rope drawing grooves are formed in the upper end and the lower end of the fixing band body along the edges, corresponding drawing ropes are arranged in the rope drawing grooves, and the other ends of the drawing ropes are movably connected with contraction blocks. The upper end of the side, attached to the skin, of the fixing band body is fixedly connected with a first air bag, the lower end of the side, attached to the skin, of the fixing band body is fixedly connected with a second air bag, and the fan-shaped tourniquet with the wide upper portion and the narrow lower portion can better adapt to differences of limb shapes and sizes of different patients; according to the tourniquet, the fixing band body is arranged, the attaching degree of the fixing band body and the limb is further adjusted through the drawing rope, the tourniquet can be tightly attached to the limb parts with different thicknesses, the multiple air bags can distribute pressure more evenly, and the risk of tissue ischemia and even necrosis caused by uneven pressure is reduced.

The invention belongs to the technical field of medical image processing, and particularly relates to a glioma segmentation method based on a multimodal fusion network guided by anatomical symmetry, which comprises the following steps of: jointly inputting an FLAIR image, a T2 image, a T1 image and a T1c image of the same glioma into a trained image segmentation model, and outputting a predicted segmentation image by the trained image segmentation model, the prediction segmentation image is a glioma MRI image with three segmentation areas obtained through prediction, and the three segmentation areas are an edema area, an enhanced tumor area and a necrosis area respectively; the image segmentation model comprises an encoder, a jump connection part and a decoder; the encoder comprises an ASG module, the jump connection part comprises an IMP module, and the decoder comprises a CMF module. Through a three-module cooperation mechanism, the performance of tumor localization, cross-modal fusion, subregion segmentation and the like is improved, and a reliable image basis is provided for glioma operation plan formulation, prognosis evaluation and personalized treatment decision.

Apparatus and methods for deactivating bronchial nerves and ablating smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits ultrasound so as to heat tissues throughout a relatively large impact volume (13) to a temperature sufficient to inactivate nerve conduction and ablate smooth muscle but insufficient to cause rapid ablation or necrosis of the surrounding tissues. The treatment can be performed without locating or focusing on individual bronchial nerves or smooth muscle.

The invention belongs to the field of plant protection, and particularly relates to a construction method of a CMV (cytomegalovirus) satellite RNA (Ribonucleic Acid) biocontrol mutant and application of the CMV satellite RNA biocontrol mutant to tomatoes. The invention provides a construction method of a CMV (Cytomegalovirus) satellite RNA (Ribonucleic Acid) biocontrol mutant. According to the construction method, a key basic group for inducing tomato necrosis in satellite RNA is changed, so that the risk that the satellite RNA is converted into necrotic satellite RNA is reduced. Compared with a parent Yi strain, the CMV satellite RNA biocontrol mutant is mutated at at least any one of the following six sites: G328, G331, G337, C344, C349 and C354. The invention also provides an application of the CMV satellite RNA biocontrol mutant obtained by construction at the same time, so that the pathogenic risk of plants is reduced.

The invention discloses a quantitative index determination method and device based on a hepatitis pathology image, equipment, a medium and a product, and relates to the field of medical pathology image artificial intelligence analysis, and the method comprises the steps: obtaining an image of a liver puncture pathology section; according to the image of the hepatic puncture pathological section, performing feature extraction by using a multi-stage model cascade architecture to obtain a pathological feature result; the multi-stage model cascade architecture comprises an improved VM-UNet segmentation model and a VM classification model based on FEM enhancement, and the VM classification model is connected with the improved VM-UNet segmentation model; the pathological feature result comprises the expansion level of the manifold area, the necrosis type of the manifold area and the inflammatory cell information of the manifold area; and calculating a quantitative index according to the pathological feature result. According to the invention, the accuracy, objectivity, consistency and repeatability of identification can be improved.

The invention belongs to the technical field of medical instruments, and particularly relates to a prostate microwave ablation device which comprises a handle, an outer catheter is fixed to one end of the handle, an ablation cavity and a flushing cavity are formed in the outer catheter, and a needle outlet is formed in the end, away from the handle, of the outer catheter. The ablation cavity and the needle outlet are communicated with each other, the flushing cavity and the needle outlet are communicated with each other, a coil driving unit is assembled at the end, close to the outer catheter, of the interior of the handle, a needle advancing and retreating button is assembled at the upper end of the handle, and the coil driving unit and the needle advancing and retreating button are electrically connected through a wire. The prostate focus tissue is rapidly heated to about 150 DEG C through microwave energy, thermal coagulation and necrosis of the focus tissue are achieved, the method has the advantages of being rapid in effect taking and low in recurrence rate, meanwhile, water molecules are gasified through high temperature, the ablation process is conveniently monitored in real time through ultrasonic images, and compared with the prior art, the diameter is obviously reduced, and implementation of a soft needle is facilitated.

A computer implemented method of distinguishing tumor progression from treatment-related necrosis in digital images of a subject implements a multimodal deep learning architecture from MRI data of a selected anatomical portion of the subject, such as a brain, and corresponding dPET data for the subject with a tracer applied to the anatomical portion of the subject. The computer stores co-registered MRI data frames with dPET data frames as three dimensional (3D) parametric PET maps to identify multi-modal image features of segmented tumor data. A convolutional neural network uses MRI data and selected multi-modal image features as inputs and the computer concatenates respective output latent feature vectors from the respective sections of the at least one CNN. Feeding concatenated feature vectors to fully connected layers of the multimodal architecture distinguishes tumor progression from treatment-related necrosis of the anatomical portion of the subject.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to application of a traditional Chinese medicine composition in preparation of anti-hepatoma medicines. The traditional Chinese medicine composition comprises red ginseng, ox horn tip, musk, borneol, safflower, bezoar, radix aconiti lateralis praeparata slice, venenum bufonis, pseudo-ginseng, benzoin and pearl. Experimental results show that the traditional Chinese medicine composition can induce apoptosis and necrosis of liver cancer cells and inhibit proliferation of the liver cancer cells; and liver cancer cells are retarded to be in a G1 cell cycle. Therefore, the invention provides a new therapeutic drug for clinical treatment of liver cancer, and the raw materials are natural medicinal materials, have wide sources and have good application prospects.

The invention belongs to the technical field of medicines, and particularly relates to application of hordenine in preparation of a medicine for treating and relieving tissue damage. It is found that hordenine shows the effect of relieving immunological liver injury and spleen injury on an animal model, therefore, the application of hordenine to preparation of the medicine for treating and relieving tissue injury is provided, hordenine shows a remarkable curative effect, symptoms of immunological liver injury and pathological injury of spleen and thymus can be effectively relieved, and the hordenine can be used for preparing the medicine for treating and relieving tissue injury. The conditions include abnormal liver cell morphology, inflammatory cell tissue infiltration, pathological injuries such as extravasated blood and necrosis, cell apoptosis and the like. Animal experiments show that no obvious toxic reaction or side effect is observed while the hordenine is used for relieving immunological liver injury, spleen injury and thymus injury.

The invention discloses a nasopharyngeal carcinoma necrosis prediction method and device based on feature fusion and a medium, and the method comprises the steps: obtaining multi-modal medical data of a target patient at a plurality of preset time points, and extracting medical features in different modals for each time point, so as to form a medical time sequence feature matrix in different modals; inputting the medical time sequence feature matrixes in the different modes into a gated twin-tower Transform network, and performing feature fusion on the medical time sequence feature matrixes in the different modes through a preset inter-channel-time step cross attention mechanism to obtain key image fusion features and nasopharyngeal carcinoma necrosis risk prediction results; and if the nasopharyngeal carcinoma necrosis risk prediction result is greater than a preset risk threshold, inputting the key image fusion features and the original three-dimensional image data into a 3D nnU-Net network to generate a nasopharyngeal carcinoma necrosis prediction map of the target patient. The prediction accuracy of nasopharyngeal carcinoma necrosis can be improved.

The invention belongs to the field of biological medicines, and discloses application of flufenidone in preparation of a medicine for treating pancreatic diseases. Researches find that the flufenidone can improve serum amylase and lipase levels of an acute pancreatitis model mouse, and can improve pancreatic tissue edema, necrosis and inflammatory cell infiltration of the acute pancreatitis model mouse; the traditional Chinese medicine composition can improve acute pancreatitis model mouse lung tissue alveolar interval thickening and inflammatory cell infiltration, and provides guarantee for application of the traditional Chinese medicine composition in preparation of drugs for treating pancreatic diseases.

A method and kit are provided for detecting anti-drug antibodies (ADAs) against self-assembling trimeric biologics, such as XPro1595, a pegylated variant of soluble human Tumor Necrosis Factor, in biological samples, particularly human serum. The method employs an Affinity Capture Elution-Protein A / G (ACE-AG) assay that overcomes non-specific reagent interactions inherent in conventional bridging and standard ACE assays due to the biologic's dynamic monomer exchange. The assay utilizes a two-plate system: a streptavidin-coated plate with biotinylated trimeric biologic captures ADAs, which are eluted, neutralized, and transferred to a protein A / G-coated plate for specific immunoglobulin capture and detection with a sulfo-tagged trimeric biologic via electrochemiluminescence. The kit includes pre-coated plates, labeled biologics, elution and neutralization solutions, assay buffer, confirmatory reagent, and instructions. The assay offers a robust, specific, and sensitive solution for immunogenicity testing of trimeric biologics.

The invention relates to the technical field of plant virus detection, in particular to a system and a method for detecting areca yellowing related viruses based on an RPA-LFD technology. The primer group for detecting the areca yellows virus APV1 is characterized by comprising a specific primer pair, the nucleotide sequence of an upstream primer in the specific primer pair is as shown in SEQ ID No.1 in a sequence table, and the nucleotide sequence of a downstream primer is as shown in SEQ ID No.2 in the sequence table; the device further comprises a probe. The probe is labeled and modified by biotin or FAM fluorophore; the nucleotide sequence of the modified probe is as shown in SEQ ID No.3 in the sequence table. The kit has the advantages that the kit has higher specificity and lower detection limit in the aspect of detection, and has no cross reaction with other viruses such as areca necrotic ringspot virus; the primer probe combination is suitable for RPA-LFD detection, and the time required by an amplification reaction is short; the reaction result is shown on the test strip and can be observed by naked eyes.

The invention discloses application of an NR1D1 protein phosphorylation site in preparation of cerebral hemorrhage treatment drugs, and belongs to the technical field of molecular biology. According to the invention, the specific phosphorylation site and phosphorylation modification level of the NR1D1 protein are determined for the first time, and the NR1D1 protein can be used as a key marker for evaluating the secondary nerve injury degree of the hemorrhagic cerebral apoplexy and developing treatment and / or alleviation of the hemorrhagic cerebral apoplexy; a specific antigen peptide and an antibody for accurately detecting the NR1D1 protein phosphorylation site are further constructed, and an efficient tool is provided for molecular evaluation of hemorrhagic stroke secondary nerve injury; meanwhile, polypeptide molecules capable of inhibiting NR1D1 protein phosphorylation are researched and developed, through the dual effects of specifically blocking the phosphorylation process and reducing protein degradation, necrosis of brain tissues around hematoma after hemorrhagic cerebral apoplexy is relieved, secondary dyskinesia is improved, and the effect of inhibiting NR1D1 protein phosphorylation is achieved. And a brand new scheme is provided for molecular evaluation and targeted intervention of hemorrhagic stroke secondary nerve injury.

The invention discloses application of senkyunolide I in preparation of a medicine for preventing and treating organ injury and / or cytotoxicity induced by cis-platinum, and belongs to the field of medicines, and the mass fraction of the senkyunolide I is greater than or equal to 90%; through a large number of tests, the inventor finds that senkyunolide I can reduce cytotoxicity induced by cis-platinum and improve cell activity; the kidney injury caused by cisplatin chemotherapy is relieved, and the renal tubule injury caused by cisplatin is relieved; the liver injury caused by cisplatin chemotherapy is relieved, the activity of glutamic oxalacetic transaminase and glutamic-pyruvic transaminase induced by cisplatin is reduced, and the degeneration and necrosis of liver cells caused by cisplatin are relieved; moreover, the senkyunolide I can be orally administered, so that the safety risk and adverse reaction caused by the conventional amifostine injection administration can be solved, and the senkyunolide I is expected to be developed into a cisplatin chemotherapy adjuvant drug which can be orally administered.

The present invention relates to a circular RNA for targeted inhibition of fish neural necrosis virus replication, as well as a preparation method and application thereof. The circular RNA is NNV-circRNA-1, whose nucleotide sequence is shown in SEQ ID NO:1. The circular RNA is prepared by cyclizing linear NNV-circRNA-1 with T4 RNA ligase 1 and then removing residual linear RNA in the reaction system using RNase R enzyme. The circular RNA prepared by the present invention has good stability and high purity. NNV-circRNA-1 has a strong binding ability with NNV-RdRp protein, can effectively inhibit the replication of NNV virus, and can be used in the preparation of vaccines, antiviral drugs and other biological immune products for fish neural necrosis virus in the field of aquaculture.

The present invention relates to modulators of TNF signalling for use in treating and / or preventing acute pain. In particular, a modulator of TNF signalling may be a tumour necrosis factor receptor 2 (TNFR2) agonist comprising (i) a TNFR2 binding domain comprising three TNF homology domains (THD) that specifically bind to TNFR2; and (ii) an Fc domain. The present invention further relates to combinations of a TNFR2 agonist and an inhibitor of tumour necrosis factor receptor 1 (TNFR1) signalling.

The invention discloses a negative pressure suction sheath capable of monitoring high pressure in a renal pelvis, and relates to the technical field of medical instruments, the negative pressure suction sheath comprises a sheath tube body, the end part of the sheath tube body is communicated with a sheath tube joint, and the sheath tube joint comprises a negative pressure joint, an instrument channel, a pressure release valve and a pressure measuring interface; the sheath tube body comprises a pressure measuring channel, a pressure measuring hole and a negative pressure suction channel. Through an independent pressure measuring channel composed of the pressure measuring connector, the pressure measuring channel and the pressure measuring hole, the pressure measuring connector, the pressure measuring channel and the pressure measuring hole are matched with a pressure release valve overflow monitoring mode or an external pressure sensor mode, the pressure change in the renal pelvis is captured in real time, when the pressure is close to or reaches a safety threshold value, medical staff can adjust the perfusion flow and the negative pressure parameter in time, and the operation is convenient. Medical accidents such as renal pelvis tissue swelling and necrosis caused by too high pressure are effectively avoided, so that the pressure in the renal pelvis is maintained within a safe range, the safety of an operation is greatly improved, the stone removing efficiency is improved, and the operation time is shortened.

Humanized monoclonal anti-nuclear antibodies with enhanced binding affinity and tumor uptake are presented. Particularly preferred antibodies are site-directed mutants of H-CDR3 with up to about 8-fold improvement in affinity as compared to the non-humanized non-mutated form. In further preferred aspects, such humanized antibodies are employed in tumor necrosis targeted delivery of immune modulators, immune effectors, and other therapeutic or diagnostic agents.

The utility model discloses a position changing auxiliary device for surgical operation nursing, which belongs to the technical field of medical equipment and comprises a bed body, a groove is arranged on one side of the top of the bed body, a backup plate hinged with the bed body is arranged above the groove, a support component is arranged in the groove, and the support component is connected with the bed body. Supporting plates are fixedly connected to the two sides of the top of the bed body, sliding grooves are formed in the sides, away from the interior of the mounting groove, of the inner walls of the two supporting plates, and a massage assembly capable of being movably adjusted is arranged on the side, away from the backup plate, of the top of the bed body. The adjustable design is suitable for patients of different heights to use, the vibration motor drives the massage head to vibrate, blood circulation of the legs of the patients is accelerated, necrosis and other situations caused by long-time too slow blood circulation of the legs are reduced, meanwhile, the upper bodies of the patients can be conveniently lifted for nursing, and the situation that the bodies of the patients are difficult to lift is avoided.

The invention discloses a prostate cancer postoperative anti-displacement fixing nursing device, which relates to the technical field of medical treatment, and comprises a fixing ring, a fixing rod, a fixing rod and a fixing rod, the fixing bags are uniformly distributed on the inner wall of the fixing ring in the circumferential direction, and the fixing bags are inflated to expand and deform to form continuous pressure contact points with the skin surface of the sponge body so as to restrain the fixing ring on the sponge body; and the pressure relief units are uniformly distributed on the fixing ring in the circumferential direction and correspond to the fixing bags. Through the arrangement of the rotating ring, the adjusting plate and the fixing bag, periodic pressure release can be achieved, so that the situation that the sponge body is prone to necrosis under long-time pressure is effectively avoided, meanwhile, the wearing comfort of a patient is improved, and the nursing performance of the device is improved.

The utility model relates to a catheter with a variable pipe diameter, and belongs to the technical field of medical instruments. Comprising a catheter body internally provided with a urinary catheterization channel. The first sleeve is coaxially connected to the outer part of the catheter main body in a sleeving manner; the elastic anchoring sleeve is coaxially connected to the exterior of the first sleeve in a sleeving mode, and a second annular channel is defined by the elastic anchoring sleeve and the outer wall of the first sleeve; and the pressure release structure is communicated with the second annular channel and is configured to be in an open state or a closed state based on the fluid pressure in the second annular channel. The elastic anchoring sleeve can reliably prevent excessive radial pressure applied to urethral mucosa due to excessive expansion of the elastic anchoring sleeve, so that serious complications such as ischemia, edema, pressure necrosis and even long-term urethrostenosis caused by long-term compression of local tissues are effectively avoided.

The invention relates to the field of aquaculture, in particular to a preparation method and application of a recombinant live vector vaccine for infectious hematopoietic necrosis of fish. In order to solve the problem of prevention and control of the infectious hematopoietic necrosis of the fish in the aquatic product industry, a replication-defective adenovirus type 5 is selected as a target gene expression vector to construct a recombinant adenovirus vector comprising a glycoprotein gene and a nucleoprotein gene of the infectious hematopoietic necrosis virus of the fish, and a recombinant virus is obtained; the safe and effective recombinant live vector vaccine for the infectious hematopoietic necrosis of the fish is created. According to the vaccine, immunization is carried out on fishes in a soaking or bait feeding mode, the total CPM of the fishes immunized by the vaccine is 6.67%, and the total CPM of the fishes in a non-immunized control group is 94.00%. In addition, the RPS of the vaccination group fish and the RPS of the empty vector control group fish are 92.90% and 9.22% respectively. The method is at a leading level in the field of fish biological medicines at present and has remarkable creativity.

The present invention relates to the field of biomedicine technology, and specifically discloses an mRNA based on the CP protein gene of fish nervous necrosis virus, a vaccine, and a preparation method and application thereof. The present invention provides an mRNA of fish nervous necrosis virus, the nucleotide sequence of which is shown in SEQ ID NO: 1, and the structure includes a 5' untranslated region, a signal peptide sequence, an NNV virus antigen coding region, a 3' untranslated region and polyA. The mRNA vaccine contains the ORF sequence of the capsid protein CP gene that is resistant to NNV virus infection. The results of animal safety tests on the fish nervous necrosis virus mRNA vaccine prepared by the present invention show that the vaccine is safe and effective, and is convenient and simple to use clinically, and has broad application prospects in the prevention and control of viral nervous necrosis in marine cultured fish.

The application discloses an ultrasonic scalpel biological tissue damage degree evaluation method and system, and belongs to the technical field of damage degree evaluation. The method comprises the following steps: acquiring multi-dimensional input data for damage evaluation, constructing a biological tissue damage evaluation model, and fusing the following mechanisms in the modeling process: calculating the coupling energy flux of the ultrasonic scalpel head-biological tissue interface, analyzing target working condition characteristic indexes, obtaining a coupling energy flux deviation value, determining biological tissue damage degree evaluation first execution information, calculating biological tissue heat flux based on a two-dimensional Pennes biological heat transfer model, determining biological tissue damage degree evaluation second execution information, and obtaining an ultrasonic scalpel biological tissue damage degree evaluation result. The application can more accurately predict the tissue heat dose, necrosis depth and heat affected zone range, and improve the precision and reliability of the ultrasonic scalpel biological tissue damage degree evaluation.

The invention discloses an application of Rottlerin in preparation of a medicine for preventing and treating nervous necrosis virus. According to the application disclosed by the invention, the fact that the rotinidin has high binding energy to RGNNV capsid protein is found, the rotinidin without toxic concentration is selected to carry out an RGNNV virus infected cell experiment, and the result shows that the rotinidin inhibits the replication of the RGNNV virus in a dose-dependent manner. The safe dosage of Rottlerin is obtained according to the survival rate of zebrafish treated with different doses, the influence of Rottlerin on the survival rate of zebrafish infected with RGNNV is researched, and finally it is proved that Rottlerin has a remarkable treatment effect on zebrafish infected with RGNNV. Rottlerin provides a new natural small molecule drug choice for prevention and treatment of VNN diseases, and has important research and development value and development significance for prevention and treatment of nervous necrosis viruses.