143 results about "Necrosis" patented technology

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and / or skin repositioning and / or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

Apparatus and methods for deactivating bronchial nerves and ablating smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An ultrasonic transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The ultrasonic transducer emits ultrasound so as to heat tissues throughout a relatively large impact volume (13) to a temperature sufficient to inactivate nerve conduction and ablate smooth muscle but insufficient to cause rapid ablation or necrosis of the surrounding tissues. The treatment can be performed without locating or focusing on individual bronchial nerves or smooth muscle.

The invention discloses a quantitative index determination method and device based on a hepatitis pathology image, equipment, a medium and a product, and relates to the field of medical pathology image artificial intelligence analysis, and the method comprises the steps: obtaining an image of a liver puncture pathology section; according to the image of the hepatic puncture pathological section, performing feature extraction by using a multi-stage model cascade architecture to obtain a pathological feature result; the multi-stage model cascade architecture comprises an improved VM-UNet segmentation model and a VM classification model based on FEM enhancement, and the VM classification model is connected with the improved VM-UNet segmentation model; the pathological feature result comprises the expansion level of the manifold area, the necrosis type of the manifold area and the inflammatory cell information of the manifold area; and calculating a quantitative index according to the pathological feature result. According to the invention, the accuracy, objectivity, consistency and repeatability of identification can be improved.

The invention discloses a nasopharyngeal carcinoma necrosis prediction method and device based on feature fusion and a medium, and the method comprises the steps: obtaining multi-modal medical data of a target patient at a plurality of preset time points, and extracting medical features in different modals for each time point, so as to form a medical time sequence feature matrix in different modals; inputting the medical time sequence feature matrixes in the different modes into a gated twin-tower Transform network, and performing feature fusion on the medical time sequence feature matrixes in the different modes through a preset inter-channel-time step cross attention mechanism to obtain key image fusion features and nasopharyngeal carcinoma necrosis risk prediction results; and if the nasopharyngeal carcinoma necrosis risk prediction result is greater than a preset risk threshold, inputting the key image fusion features and the original three-dimensional image data into a 3D nnU-Net network to generate a nasopharyngeal carcinoma necrosis prediction map of the target patient. The prediction accuracy of nasopharyngeal carcinoma necrosis can be improved.

The invention discloses application of an NR1D1 protein phosphorylation site in preparation of cerebral hemorrhage treatment drugs, and belongs to the technical field of molecular biology. According to the invention, the specific phosphorylation site and phosphorylation modification level of the NR1D1 protein are determined for the first time, and the NR1D1 protein can be used as a key marker for evaluating the secondary nerve injury degree of the hemorrhagic cerebral apoplexy and developing treatment and / or alleviation of the hemorrhagic cerebral apoplexy; a specific antigen peptide and an antibody for accurately detecting the NR1D1 protein phosphorylation site are further constructed, and an efficient tool is provided for molecular evaluation of hemorrhagic stroke secondary nerve injury; meanwhile, polypeptide molecules capable of inhibiting NR1D1 protein phosphorylation are researched and developed, through the dual effects of specifically blocking the phosphorylation process and reducing protein degradation, necrosis of brain tissues around hematoma after hemorrhagic cerebral apoplexy is relieved, secondary dyskinesia is improved, and the effect of inhibiting NR1D1 protein phosphorylation is achieved. And a brand new scheme is provided for molecular evaluation and targeted intervention of hemorrhagic stroke secondary nerve injury.

The present invention relates to modulators of TNF signalling for use in treating and / or preventing acute pain. In particular, a modulator of TNF signalling may be a tumour necrosis factor receptor 2 (TNFR2) agonist comprising (i) a TNFR2 binding domain comprising three TNF homology domains (THD) that specifically bind to TNFR2; and (ii) an Fc domain. The present invention further relates to combinations of a TNFR2 agonist and an inhibitor of tumour necrosis factor receptor 1 (TNFR1) signalling.

The invention discloses a negative pressure suction sheath capable of monitoring high pressure in a renal pelvis, and relates to the technical field of medical instruments, the negative pressure suction sheath comprises a sheath tube body, the end part of the sheath tube body is communicated with a sheath tube joint, and the sheath tube joint comprises a negative pressure joint, an instrument channel, a pressure release valve and a pressure measuring interface; the sheath tube body comprises a pressure measuring channel, a pressure measuring hole and a negative pressure suction channel. Through an independent pressure measuring channel composed of the pressure measuring connector, the pressure measuring channel and the pressure measuring hole, the pressure measuring connector, the pressure measuring channel and the pressure measuring hole are matched with a pressure release valve overflow monitoring mode or an external pressure sensor mode, the pressure change in the renal pelvis is captured in real time, when the pressure is close to or reaches a safety threshold value, medical staff can adjust the perfusion flow and the negative pressure parameter in time, and the operation is convenient. Medical accidents such as renal pelvis tissue swelling and necrosis caused by too high pressure are effectively avoided, so that the pressure in the renal pelvis is maintained within a safe range, the safety of an operation is greatly improved, the stone removing efficiency is improved, and the operation time is shortened.

The application discloses an ultrasonic scalpel biological tissue damage degree evaluation method and system, and belongs to the technical field of damage degree evaluation. The method comprises the following steps: acquiring multi-dimensional input data for damage evaluation, constructing a biological tissue damage evaluation model, and fusing the following mechanisms in the modeling process: calculating the coupling energy flux of the ultrasonic scalpel head-biological tissue interface, analyzing target working condition characteristic indexes, obtaining a coupling energy flux deviation value, determining biological tissue damage degree evaluation first execution information, calculating biological tissue heat flux based on a two-dimensional Pennes biological heat transfer model, determining biological tissue damage degree evaluation second execution information, and obtaining an ultrasonic scalpel biological tissue damage degree evaluation result. The application can more accurately predict the tissue heat dose, necrosis depth and heat affected zone range, and improve the precision and reliability of the ultrasonic scalpel biological tissue damage degree evaluation.

The invention discloses a femoral head necrosis prediction system and method based on Transform, and belongs to the technical field of image processing, the system comprises a data acquisition module, a data processing module, a data balancing module, a feature extraction module, a feature merging module and a necrosis classification module; the method comprises the following steps: acquiring preoperative hip joint CT data, pre-processing to unify specifications, adopting directional data enhancement to solve the problem of class imbalance, extracting features by virtue of Video Swin Transform, merging and modeling a spatial relationship through volume blocks, and finally outputting a necrosis classification result. According to the femoral head necrosis prediction system and method based on Transform provided by the invention, the prediction accuracy and robustness are effectively improved, the problem of model instability caused by strong subjectivity, hysteresis and data imbalance in the prior art is solved, an objective and efficient prediction tool is provided for clinic, and the risk of postoperative complications is reduced.

This disclosure provides methods for treating tumors, reducing tumor severity, inhibiting tumor growth, or inducing tumor necrosis, wherein the methods include: selecting a patient with cancer (e.g., liver cancer, lung cancer, or head and neck cancer) in need of treatment and administering neoadjuvant therapy to the patient in a combination of a therapeutically effective amount of a programmed death 1 (PD-1) inhibitor (e.g., cimiprimab or its bioequivalent) and radiation therapy (e.g., SBRT) or an anti-LAG-3 antibody (e.g., fenpromab), followed by surgical resection and optionally administration of a programmed death 1 (PD-1) inhibitor (e.g., cimiprimab or its bioequivalent) as postoperative adjuvant therapy. In some embodiments, the cancer is liver cancer, such as hepatocellular carcinoma (HCC).

The invention belongs to the technical field of multi-channel organoid culture, and particularly relates to a multi-channel organoid culture workstation which comprises a placing mechanism, the placing mechanism is placed on the ground, the placing mechanism is used for carrying out limiting placing on the clamping and channel mechanisms, meanwhile, the placing mechanism is further used for carrying out revolution and rotation motion on the clamping and channel mechanisms, the clamping and channel mechanisms are installed on the periphery of the surface of the placing mechanism, and the clamping and channel mechanisms are used for carrying out clamping fixing and extended pipetting on the cultivation mechanism; through collaborative design of a second driving assembly, a limiting assembly and an autorotation mechanism of the placement mechanism, a revolution and autorotation dual-motion mode of the culture mechanism is realized, in-vivo tissue peristalsis is simulated, nutrient circulation is promoted, and the defects of uneven nutrient diffusion and high organoid center necrosis rate caused by static culture of existing equipment are overcome.

The Endoscopic Adjustable Gastric Barrier represents a groundbreaking innovation in the management of obesity, offering a unique, minimal invasive approach without the complications and limitation of other currently available interventional managements., this revolutionary technique works by dividing the stomach into a smaller, tube-like space for food, without altering the stomach's natural anatomy or functions. This preserves the stomach's function to produce hormones and digestive juices, while effectively reducing food intake hence significant weight loss. What makes this innovation (EAGB) unique is its adjustability and reversibility, and when ideal weight is achieved it can be removed endoscopically. It is secured to the stomach by clips with minimal injury and without risk of necrosis and leak. Additionally, all endoscopic and laparoscopic interventions are possible as normal population.

The present application relates to a kind of carp herpesvirus II type ORF150 gene deletion strain and its preparation method and application, belong to aquatic animal disease prevention and control technical field.The present application carp herpesvirus II type ORF150 gene deletion strain preservation number is CCTCC NO:V202603, is preserved in China typical culture preservation center, and is named carp herpesvirus 2 type CyHV-2-SS24-Δ150-GFP Cyvirus cyprinidallo2 The virulence of the present application carp herpesvirus II type ORF150 gene deletion strain is significantly weakened, but still retains good immunogenicity, can induce the immune fish body to produce immune protection to carp herpesvirus II type.ORF Therefore, the present application carp herpesvirus II type ORF150 gene deletion strain can be used as live attenuated vaccine to carp herpesvirus II type, prevent koi and its variety in aquaculture from being infected by carp herpesvirus II type and lead to hematopoietic organ necrosis disease.

The invention discloses a method for establishing a mouse radioactive jawbone injury animal model, which comprises the following steps of: performing tooth extraction operation, performing radiation treatment after one day, and performing Micro-CT (Computed Tomography) scanning, intraoral examination and histopathologic detection on the lower jawbone on the thirteenth day after radiation so as to determine that the radioactive jawbone injury mouse model is successfully constructed. The animal model has the advantages that the pathological process of human early radioactive jaw necrosis is accurately simulated; the model is stable, good in repeatability and suitable for large-scale experimental research; and a reliable, short-cycle and convenient-to-operate animal model is provided for the mechanism research of radioactive jaw necrosis and the development of new drugs.

The invention discloses a severed finger replantation postoperative necrosis risk assessment method, device and equipment and a readable storage medium, and relates to the technical field of artificial intelligence. Comprising the following steps: firstly, acquiring severed finger replantation related data of a sample patient; screening out target data of which the influence degree on the severed finger replantation postoperative necrosis risk assessment result is greater than a preset value from the severed finger replantation related data by using Lasso regression and a Boruta algorithm; then training candidate models based on the target data, and screening out a target model from the candidate models according to the prediction performance of each candidate model; and finally, obtaining target data of a target patient, and inputting the target data of the target patient into the target model to obtain an evaluation result of the severed finger replantation postoperative necrosis risk of the target patient. And the evaluation accuracy of the severed finger replantation postoperative necrosis risk is obviously improved.

Provided are polypeptides comprising an amino acid sequence at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99%, or 100% identical to the amino acid sequence selected from the group consisting of SEQ ID NO: 1-73 and 99-100, wherein the polypeptide binds to a tumor necrosis superfamily receptor, fusion proteins thereof, and methods for their use.

The invention relates to the field of biomedical detection, and particularly discloses a kit for detecting chromosome alloploid necrotic cells and application thereof, the kit comprises a metabolism tracer, a lactic acid specific binding probe connected with a detectable marker, a membrane-impermeable nucleic acid dye and a DNA metal mutual embedding agent; the use method comprises the following steps: co-incubating a to-be-detected sample and the metabolic tracer agent to enable cells to generate labeled lactic acid; sequentially contacting with a lactic acid probe, a membrane-impermeable nucleic acid dye and a DNA metal mutual embedding agent; and finally analyzing the cell state by detecting each signal. According to the method, the metabolic activity, the cell dead and living state and the DNA ploidy are synchronously detected on the single cell level, the special cell subpopulation with high glycolytic activity, necrosis characteristics and chromosome heteroploidy can be accurately recognized, and the technical problem that multi-dimensional cell information is difficult to integrate and analyze is solved; the kit has important application value in cancer diagnosis, prognosis evaluation, curative effect monitoring and drug screening.

A dental implant comprises a base main body arranged in a dental implant main body and a guide block arranged at the bottom end of the dental implant main body, the dental implant main body is in threaded connection with the base main body, and the dental implant main body is fixedly connected with the guide block; the dental implant main body comprises a first end head and a vertical part, the first end head is fixedly connected with the vertical part, and a threaded groove is formed in the inner wall of the first end head. The dental implant has the beneficial effects that through the arrangement of the fixing mechanism, the contact area between the dental implant and an alveolar bone can be reduced during installation, so that the heat generated during installation is reduced, the problem of bone cell necrosis easily caused by over-high temperature is avoided, and meanwhile, after the dental implant is installed, the bone cell necrosis can be avoided. The friction force between the dental implant and the alveolar bone can be increased, so that the situation that the dental implant slightly moves in the alveolar bone and synostosis formed between the dental implant and the alveolar bone is damaged when the abutment is rotated is avoided.

The application belongs to the technical field of medicine, and particularly relates to a muscone derivative, a preparation method and application thereof. The muscone derivative cyclopentadecanedione monoxime has obvious advantages over muscone and other derivatives in improving the MCAO rat mNSS score, microcirculation blood flow, reducing the cerebral infarction rate, the cortical and hippocampal neuron necrosis rate, and the brain water content, and increasing the SOD and CAT contents of the rat brain tissue which are abnormally reduced due to ischemia, and is a potential effective drug for cerebral ischemia-reperfusion injury.

The invention discloses a motion intervention heart failure repair method based on Lgmn signal regulation and control, and relates to the technical field of heart failure treatment. According to the method, through aerobic exercise training (AET) with specific parameters, expression of Legumain (Lgmn) genes in macrophages is regulated in a targeted mode, the interburial effect of the macrophages is enhanced, then cell communication between the macrophages and cardiac muscle cells is enhanced, removal of the vertical death cardiac muscle cells is promoted, myocardial fibrosis and inflammatory response are relieved, and the effect of treating myocardial fibrosis is achieved. Finally, ventricular remodeling and heart functions of chronic heart failure (CHF) mice are improved. Experimental verification shows that the exercise intervention method can significantly improve the left ventricular ejection fraction (LVEF) and shortening fraction (FS) of CHF model animals, reduce the left ventricular end-of-systole inner diameter (LVESD), reduce myocardial cell apoptosis and necrosis, and promote inflammation regression. Drug intervention is not needed, safety is high, operation is easy and convenient, and a new effective way is provided for clinical rehabilitation treatment of heart failure.

The present invention relates to the technical field of prevention and control of aquatic animal diseases, and specifically relates to a nanocomposite for a nervous necrosis virus, a preparation method therefor, and the use thereof. Provided in the present invention is a nanocomposite consisting of poly(lactic-co-glycolic acid), polyethyleneimine and a siRNA. Also provided in the present invention are a preparation method for the nanocomposite and the use thereof in the preparation of a drug for improving the survival rate of fish eggs infected with a nervous necrosis virus. The present invention constructs a vector for a capsid protein of the nervous necrosis virus by means of simulating the nervous necrosis virus and expresses same in cells, and screens out a siRNA that can effectively inhibit the expression of the viral capsid protein, thus constructing the nanocomposite for the nervous necrosis virus. The nanocomposite can block NNVs at the embryonic phase (fertilized eggs), thereby improving the survival rate of fish fry, and further opening up new possibilities for the treatment of early stage diseases in fish fry. The method is innovative in the field of artificial breeding of aquatic animals and provides new ideas for virus prevention and control in the field of aquaculture.

This invention relates to the field of eDNA enrichment and detection, and discloses a highly efficient method for the enrichment and detection of infectious hematopoietic organ necrosis virus (IHNV) eDNA. The method includes the following steps: preparing and pretreating an IHNV virus sample to obtain a standardized raw solution; subsequently, using a tangential flow enrichment device to efficiently concentrate the IHNV virus particles in the raw solution, achieving the enrichment of viral eDNA; and constructing an RT-qPCR quantitative detection system. By plotting a standard curve and a sample amplification curve, the virus recovery rate is accurately calculated, enabling accurate evaluation of the efficiency of the entire enrichment process. This invention overcomes the shortcomings of traditional methods, such as small processing volume, low efficiency, and cumbersome operation, achieving the goal of efficient and stable recovery of viruses from large-volume water samples.

A multispectral photonic imaging system and associated methods are disclosed for classifying wound tissue and generating customized therapeutic wound dressings. The system employs wavelength-specific optical sources and integrated image sensors to capture multispectral reflectance data from a wound, enabling computational classification of distinct tissue types such as granulation, slough, and necrosis. A three-dimensional (3D) digital model of the wound is constructed using spatial data from depth sensors. The classified 3D wound model facilitates automated design of patient-specific dressings, featuring heterogeneous regions tailored with therapeutic compounds like antimicrobial agents, analgesics, collagen scaffolds, and hydrogel matrices precisely aligned to corresponding tissue classifications. Additional imaging modalities, including thermal and ultrasound sensors, can be integrated to enhance classification accuracy and inform targeted therapeutic placement, providing a comprehensive and personalized approach to wound management for medical and veterinary applications.

The invention discloses a fish nervous necrosis virus resisting medicine which is characterized by comprising baicalin. The invention also discloses a screening method of the drug for resisting the nervous necrosis virus of the fish, which comprises the following steps: constructing a recombinant prokaryotic expression plasmid with the HSC70 gene, transferring the plasmid into a BL21 (DE3) cell, inducing protein expression, and purifying to obtain the HSC70 protein; preparing to-be-detected compound solutions with different concentrations, and then dropwise adding the to-be-detected compound solutions into the solution containing the HSC70 protein for incubation; under the excitation wavelength of 285 nm, the fluorescence signal of the HSC70 protein in the range of 310-350 nm is detected, the compound for targeted inhibition of the HSC70 protein is determined according to the change of the fluorescence signal, and the fish nervous necrosis virus resisting medicine is screened out.

The invention relates to the technical field of medical image segmentation and machine learning, and discloses a femoral head necrosis area determination model obtaining method, a necrosis area determination method, a device and equipment, and the model obtaining method comprises the steps: obtaining an image feature vector of a magnetic resonance imaging image, and inputting the image feature vector into an image neural network; forming a node set according to the image feature vector corresponding to each magnetic resonance imaging image, and constructing a graph structure based on the node set; wherein the magnetic resonance imaging image is a femoral head necrosis related image; according to the nodes in the node set and the graph structure, obtaining preliminary graph matching features in combination with a second-order graph matching algorithm; and training a graph neural network based on the preliminary graph matching features to obtain a femoral head necrosis region determination model. According to the method, the femoral head necrosis area can be accurately captured in the absence of large-scale manual labeling.

The application discloses a kind of metal organic framework material and its preparation method and application, wherein, preparation method includes the following preparation steps: zinc acetate, phycocyanin is dissolved in water, and mixed solution is prepared;Mixed solution is added to 2-methyl imidazole aqueous solution mixing stirring, centrifugation, and the precipitate is washed with water, dispersed in water, and nanoparticle dispersion is prepared;Nanoparticle dispersion, epigallocatechin gallate and manganese chloride are added to water mixing stirring, centrifugation, and the precipitate is washed with water, dispersed in water, and metal organic framework material is prepared.The metal organic framework material prepared by the application has free radical scavenging antioxidant capacity;It has anti-inflammatory effect, can reduce liver damage and necrosis, and is suitable for the treatment of acute liver injury;It also has the effects of regulating inflammatory response, promoting macrophage transformation and inhibiting T cell activation, and is suitable for immune regulation.

The invention discloses a multi-sensor joint feedback radiofrequency ablation morphology prediction system, and relates to the technical field of radiofrequency ablation minimally invasive therapy, and the system specifically comprises an ablation signal collection module which processes a signal through a distributed temperature sensor and an impedance detection path and through low-pass filtering and moving average processing; reconstructing a continuous and smooth tissue temperature field from the discrete temperature data; the core parameter calculation module is used for calculating core state parameters based on the temperature field and impedance data, setting a dynamic carbonization threshold value and a carbonization risk index, constructing a real-time necrosis degree index, presenting a necrosis area through a thermodynamic diagram and defining an ablation front edge; and the power self-adaptive closed-loop regulation and control module is used for predicting tissue state change, solving optimal test power through a target optimization function, adding carbonization risk constraint and power boundary limitation, dynamically adjusting output power, periodically updating tissue state data and repeating the whole process to form a closed loop so as to realize self-adaptive regulation and control of the ablation process.

The present disclosure provides an autologous cell therapy for treating a cancer. Transarterial tirapazamine embolization (TATE) therapy induces tumor necrosis, which, in combination with anti-PD-1 therapy, enhances the efficacy of anti-PD-1 through TATE-induced expansion of anti-tumor T cells activated by the anti-PD-1 antibody. PBMCs collected from TATE and PD-1 -treated patients for RNA and DNA extraction and next generation sequencing (NGS) analysis of complementarity region-3 of the TCR from T cell populations in the PBMCs show that clonal expansion of anti-tumor specific T cell receptors (TCRs) occurs. Expansion of the PBMC population for administration to a cancer patient preferentially expands the population of effector T cells targeting the tumor cells without a need for genetic manipulation.

This invention provides a recombinant transmembrane human tumor necrosis factor expressed in alfalfa. ‑α This method belongs to the field of biotechnology. This invention constructs a transmembrane human tumor necrosis factor... ‑α A plant binary expression vector for the gene is used, and then Agrobacterium-mediated transformation of the recipient alfalfa containing this plant binary expression vector is employed to prepare recombinant transmembrane human tumor necrosis factor. This invention utilizes alfalfa as a substrate plant for recombinant human tumor necrosis factor, providing a platform for recombinant transmembrane human tumor necrosis factor production. ‑α This provides an excellent cell system for expression, catering to the market demand for recombinant transmembrane trimeric tumor necrosis factor. ‑α This provides a new solution to the needs.

The present application relates to an adjuvant which is suitable to be used in vaccines or other immunogenic compositions. Specifically, the adjuvant promotes the induction of interleukin-1 (IL-1), type 1 interferons (IFNs), such as IFNα, and IFNβ, type 2 interferons, such as IFNγ and / or tumour necrosis factor (TNF) response, such as TNFα, and elicits or enhances an immune response, preferably in neonatal, juvenile or paediatric animal and / or human populations.