The invention provides a multifunctional mouse pad for preventing and controlling carpal tunnel syndrome. The multifunctional mouse pad is formed by main raw material selection, main raw material grinding, auxiliary raw material grinding, material mixing and filling, heating material arrangement, mouse pad bonding and sewing, package and finished product manufacture, wherein a filling material of the mouse pad includes main raw materials including cortex acanthopanacis, mistletoe, eucommia barks, homalomena occulta, flowers carthami, Chinese angelica, dried tangerine or orange peel, rehmannia glutinosa, ligusticum wallichii, radix notoginseng, radix angelicae pubescentis, frankincense and liquorice and an auxiliary raw material magnet powder. The filling material further comprises a single-row flexible heating wire mesh made of a heating material. After the technical scheme is adopted, the mouse pad having magnet therapy, pyretic moxibustion and medicine fumigation fuctions relieves the acid bulge feeling of the wrist joint and fatigue of the nerve center, effectively protects functions of the wrist joint and muscular tissues, can be used for a long period of time, medicine efficacy, magnetic force and heating power of traditional Chinese medicine powder and magnet powder in the mouse pad jointly act on the position of the carpal canal under the heating power boosting effect of the flexible heating wire mesh, and finally the purpose of preventing and controlling the carpal tunnel syndrome can be achieved. In addition, the invention further discloses a manufacturing method of the multifunctional mouse pad.