1 results about "Decreased Sensitivity" patented technology

This invention belongs to the field of molecular biology technology, specifically relating to a method and application for detecting target substances in trace samples. The detection method includes the following steps: S100: acquiring quantitative results of target substance detection in a signal correction sample, a signal reference sample, and a mixed sample; S200: correcting the quantitative results of the signal reference sample and the mixed sample using the quantitative results of the signal correction sample, obtaining corrected results for the signal reference sample and the mixed sample; S300: comparing the corrected results of the mixed sample with the corrected results of the signal reference sample to obtain the quantitative result of the target substance in the trace sample. This invention can significantly improve detection sensitivity. It reduces the dependence on ultra-high sensitivity mass spectrometers, enabling conventional mass spectrometry instruments to detect trace target substances. By setting up a signal enhancement sample, the signal of the trace target substance is made higher than the noise signal, and the peak shape is improved, thus enhancing the stability of detection in trace samples.