114 results about "Saliva collection" patented technology

A device for collecting oral fluid includes a mouthpiece with a fluid inlet connected to a collection chamber. The collection chamber includes a collecting vessel, a venting outlet, and an access port. The venting outlet may be covered by a liquid-impervious or resistant membrane, such as a hydrophobic membrane, and the access port is suitable for removing some or all of the collected fluid. This arrangement allows a saliva donor to continuously spit saliva and blow air into the closed collection chamber, without pressure build-up in the collection chamber, and without the need for the donor to release from the device until the desired oral fluid volume is collected. A valve, including a check valve may be in the saliva flow stream and baffles and structure creating a tortuous path may be utilized to keep saliva away from the membrane.

Disclosed herein are portable handheld devices for saliva collection for daily monitoring of salivary biomarkers of physiological conditions, the device comprising: a handheld handle comprising a saliva collector, the saliva collector comprising: a suction tip; a bi-directional pump electrically configurable for pumping towards two opposite directions; a saliva reservoir; a valve; a water reservoir, the water reservoir comprising an external filling lid; a reversible fluidic connection configurable in a connected and disconnected position; and a base accommodating the handheld handle, the base configurable to fluidly communicate with the handheld handle through at least the reversible fluidic connection, wherein the valve is electrically configured to allow fluid communication directly between at least two selected from: the saliva reservoir, the water reservoir, and the reversible fluidic connection, and wherein the bi-directional pump is electrically configurable to allow fluid communication directly between the suction tip and the saliva reservoir.

Sample collection apparatus and methods of sample collection are provided, for example saliva collection apparatus and methods of saliva collection. Said apparatus conveniently comprises a filter assembly and an interface for delivering material from the apparatus to an assay unit.

The invention discloses a high-efficiency saliva collection device, which includes a collection funnel, a funnel cover, a volatilization chamber for stimulating saliva secretion, a collection tube and a collection tube cover, the collection funnel and the funnel cover are connected through a connecting piece, and the The funnel cover can be seamlessly fastened on the collection funnel, the volatilization chamber for the saliva secretion-stimulating substance is provided on the fastening surface of the funnel cover, the saliva secretion stimulating pattern is printed on the inside of the funnel cover, and the collection tube The upper end is provided with an opening, and the bottom end is provided with a seal. The bottom end of the collection pipe is provided with a conical collection pipe bottom. The pipe skirt is pluggably connected to the collection pipe cover. The high-efficiency saliva collection device provided by the present invention has a simple structure, is convenient to use, avoids separate cumbersome steps, uses two nerve reflection modes of smell and vision to stimulate saliva to accelerate secretion, and shortens sample collection time.

The invention relates to a method for separating and determining multiple phenolic substances in saliva, and belongs to the technical field of analytical chemistry. The method comprises the steps of collecting a saliva sample by adopting a saliva collection tube, carrying out high-speed centrifugation after collection and then taking a supernatant; carrying out acidification, adding an internal standard and carrying out vortex oscillation until mixing evenly in sequence; and filtering with a micropore filter membrane, separating and determining multiple phenolic substances in saliva from filtrate by adopting an ultra-high performance liquid chromatography-multiwavelength fluorescence method, fabricating a standard curve and quantifying through an internal standard method. The method can be effectively used for separating and determining the multiple phenolic substances in the saliva, and the method is good in separation effect, low in detection limit, good in precision, accurate and reliable, and has popularization and application values.

A saliva collector comprises a reservoir, a bubble barrier, and a membrane, where the bubble barrier and membrane are arranged in tandem on a flow path from an inlet to an outlet on the reservoir. Air aspirated from a patient's oral cavity enters the reservoir through the inlet, passes through the bubble barrier to remove foam and bubbles, passes through the membrane to remove entrained liquid saliva, and passes out through the outlet.

Provided herein is an all-in-one saliva collection apparatus that collects saliva to allow for the filtration of saliva in order to separate saliva components, such as extracellular proteins and nucleic acids that are not present in intact cells, from the intact cells and debris remaining in the extracted sample. The filtered saliva samples can be aliquoted into two fractions for protein and/or nucleic acid analysis. The present invention further describes long term storage at ambient temperatures of filtered salivary nucleic acids, and long term storage at ambient temperatures of filtered salivary proteins added to an ethanol solution. The filtered cell-free saliva samples have diagnostic usefulness.

The invention relates to a saliva collection device which comprises a liquid storage pipe and a cover body, wherein the liquid storage pipe and the cover body are detachably connected and then form a liquid storage space internally; an isolation membrane is arranged inside the liquid storage space; the liquid storage space is segmented into two parts which are independent of each other by virtue of the isolation membrane; a piercing device is fixedly arranged in the cover body and is used for piercing the isolation membrane after the liquid storage pipe and the cover body are detachably connected with each other; and the liquid storage pipe is made of a transparent material or an opaque material. According to the saliva collection device provided by the invention, the liquid storage space is segmented into two parts which are independent of each other by virtue of the isolation membrane, and the isolation membrane is pierced during covering by utilizing the piercing device on the cover body, so that the operations of sealing ad mixing are simultaneously finished, and the problem of cross contamination among saliva samples is avoided.

The invention discloses a device for quantitative detection of ovulation, comprising a saliva collection module, an image collection module, a data transmission module and a power supply module, the saliva collection module is used for collecting saliva; the image collection module is used for collecting image data of saliva crystallization , including a microscopic device; the data transmission module is used to transmit the data collected by the image acquisition module to an external device APP module for data processing and statistical analysis; the power supply module is used to transmit data to the image acquisition module and data The module supplies power. The device has the advantages of convenient operation, high efficiency and high measurement accuracy, and can accurately calculate the ovulation time within ten hours.

Provided are methods for collecting saliva from the oral cavity of a mammal comprising: placing a mouthpiece of a device comprising the mouthpiece in the oral cavity of a mammal, the mouthpiece comprising a chamber defined by front and rear inner walls and a base inner wall of the mouthpiece, each of the front and rear inner walls of the chamber comprising a plurality of openings, and a switch disposed in the mouthpiece; and the device further comprising a saliva collection reservoir, a fluid supply reservoir, a pump, and means for directing fluid through said device; activating the switch disposed in the mouthpiece to pump saliva from the oral cavity to the saliva collection reservoir for collection; deactivating the pumping of saliva to the saliva collection reservoir; and subsequently pumping fluid from the fluid supply reservoir to the mouthpiece for cleaning or treatment of the oral cavity.

The invention relates to a saliva collector which comprises a bracket. A disposable saliva collecting mechanism and a liquid receiving pipe are detachably arranged on the bracket; and the upper end ofthe bracket is connected with a VR assembly through a longitudinal supporting frame. A smell emitting mechanism and a controller are also arranged on the supporting frame. The saliva collecting mechanism comprises a buccal unit and an inclined liquid collecting pipe which are connected with each other; the lower end of the interior of the liquid collecting pipe is coaxially and rotationally connected with an inner ring; a connecting piece detachably connected with the liquid receiving pipe is arranged at the lower end of the inner ring, and a spiral scraping piece for scraping saliva on the inner wall of the liquid collecting pipe is arranged at the upper end of the inner ring; the liquid receiving pipe is obliquely arranged on the bracket, a rotating assembly for driving the liquid receiving pipe to rotate axially is arranged on the bracket, and the rotating assembly is controlled by a controller; the upper end of the liquid collecting pipe is connected with a liquid injection pipe,an injection pump assembly for injecting saliva preservation liquid into the liquid injection pipe is arranged on the bracket, and the injection pump assembly is controlled by a controller. The detection process is very comfortable, the saliva collection efficiency is high, saliva residues are reduced, and the sampling success rate is guaranteed.

The invention discloses an apparatus for detecting and analyzing oral inner ambient of a patient via an oral tracheal cannula; the apparatus comprises a computer, a data processor, a scanning device, a travel cart and a saliva collection device; the data processor and the scanning device are connected with the computer, and the computer, the data processor and the saliva collection device are arranged on the travel cart; during detection, medical staff holds the scanning device by hand to scan the patient's lips, gums, oral mucosae, tongue and teeth, a saliva collection bottle is used to collect the patient's saliva, the data processor analyzes scanning results and saliva results, and the medical staff provides nursing for the patient according to obtained assessing results, nursing frequency and nursing time. The apparatus allows the oral ambient to be accurately assessed and analyzed so as to formulate nursing frequency and nursing time and to assist clinical nurses in formulating a reasonable oral care plan according to the oral inner ambient of the patient, thereby decreasing chances for the patient to suffer VAP (ventilator-associated pneumonia).

The invention relates to a saliva detector and belongs to the field of detection equipment. The detector comprises a saliva collecting device; the saliva collecting device is provided with a first accommodating cavity, a second accommodating cavity and a test strip mounting hole communicated with the second accommodating cavity; the saliva detector also comprises a positive pressure driving deviceand a saliva filtering device assembled to the saliva collecting device; the positive pressure driving device closes the first accommodating cavity and slides along the first accommodating cavity; thesaliva filtering device is used for filtering liquid in the first accommodating cavity and is communicated with the second accommodating cavity; the liquid is used for reacting with an immune colloidal gold test strip assembled in the test strip mounting hole. The saliva detector provided by the invention integrates saliva collection, pretreatment and inspection, and has the advantages of simplestructure, convenience and quickness in operation, no limitation imposed by site and other factors, fast detection, high sensitivity, high specificity and high safety.

The invention discloses a swallowing rehabilitation device for a patient with cerebral infarction, belonging to the technical field of rehabilitation instruments. The swallowing rehabilitation device for the patient with cerebral infarction comprises a fixing disc, a buccal device, a swallowing assisting device and a saliva collecting device, wherein the saliva collecting device, the swallowing assisting device and the buccal device are arranged on the fixing disc; the saliva collecting device is composed of a second rubber ball, a second hose and a saliva storage bottle; the fixing disc is of an annular hollow structure; water pumping openings are distributed in the peripheral face of the fixing disc and communicates with the interior of the fixing disc; one end of the second hose communicates with the interior of the fixing disc; and the other end of the second hose is connected with the second rubber ball. The swallowing rehabilitation device is simple and reasonable in structure, can effectively help a patient to carry out swallowing rehabilitation, solves the problem that when the patient carries out swallowing rehabilitation training, saliva flows out of the mouth and is difficult to clean by medical staff, and thus reduces the workload of the medical staff.

Provided is a determination method of formaldehyde-DNA adducts in saliva, namely the determination method of HOMe-dA and HOMe-dG in the saliva; the determination method includes the steps: collecting the saliva by using an OG-500 saliva collection tube, carrying out DNA extraction on the saliva, carrying out enzyme hydrolysis of the DNA solution, and successively adding a stable isotope internal standard, a reducing agent NaBH3CN and a DNA hydrolase; and carrying out solid-phase extraction of the hydrolysate with a Strata-X small column, collecting an eluted liquid, nitrogen-blowing to be dried at room temperature, redissolving in a methanol aqueous solution, introducing into an LC-MS/MS system, analyzing, and accurately detecting the content levels of Me-DA and Me-dG. The stable isotope is used as an internal standard quantitative analysis material, so the error caused by the sample pretreatment process can be reduced, and the selectivity, accuracy and sensitivity of the method can be improved by tandem mass spectrometry. Through selection and optimization of the chromatographic column and the elution conditions, the chromatographic separation process is relatively improved, the time of chromatographic analysis is shortened, and the consumption amount of an organic solvent is decreased.

Saliva offers an alternative specimen for the therapeutic monitoring of cyclosporine (CsA) in children and patients with difficult venous access. For a highly protein-bound drug such as CsA, saliva provides a practical approach for measuring the unbound concentration. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is ideally suited for the measurement of drugs in saliva. A solid-phase extraction technique, analytic liquid chromatography over an Aqua Perfect column, maintained at 65° C., and electrospray tandem mass spectrometry were used to quantify CsA in saliva. The method used cyclosporine C (CsC) as the internal standard. Mobile phase comprised of a 97:3 voL mixture of methanol and 30 mmol/L ammonium acetate at a flow rate of 0.5 mL/min. Chromatograms using mass transitions of m/z 1219.9→m/z 1202.9 for CsA and m/z 1235.9→m/z 1218.9 for CsC were obtained. The calibration curve was linear from 1 to 300 μg/L with correlation coefficient values ranging from 0.9732 to 0.9968). The lower limit of quantification was 1 μg/L and limit of detection was 0.6 μg/L with an average extraction recovery of 84.7±2.6% for CsA and 93.7±4.4% for CsC from the saliva matrix. The accuracy of the method ranged from 92% to 104.7%, and the intra- and interim coefficients of variation were 6.9-12.2% and 8.3-12.1%, respectively. The correlation coefficient value between the CsA concentration measurements in 15 paired blood-saliva samples from kidney transplant recipients was 0.695 (P=0.006). The noninvasive and simple method of saliva collection coupled with the LC-MS/MS quantification technique for CsA analysis would generate novel data that could benefit patients undergoing CsA therapy.

The invention discloses animal saliva sampling equipment for veterinarians, and belongs to the technical field of animal husbandry equipment. The animal saliva sampling equipment for veterinarians comprises a piston cylinder, a cotton yarn ball, a sleeve, a wire wheel and a controller, wherein the piston cylinder comprises a cylinder body and a piston, a cylinder cover is hinged to the opening end of the cylinder body, a clamping mechanism is further arranged on the cylinder body and used for clamping the cylinder cover to the cylinder body, a sliding hole is formed in the right end of the cylinder body, wire through holes are formed in a piston head and a piston rod of the piston, an air inlet and an air outlet are formed in the bottom of the cylinder body and located on the right side of the left end piston head, the air inlet communicates with an air supply device, and the air outlet communicates with an electromagnetic valve; the cotton yarn ball is connected with a string; the right end of the sleeve is fixedly connected with a bracket; the wire wheel is hinged with the bracket; and the controller is electrically connected with the air supply device, the electromagnetic valve and a power device. According to the animal saliva sampling equipment for the veterinarians, the livestock can be subjected to saliva collection without fixing the livestock, harm to the livestock in the saliva collection process is avoided, and the animal saliva sampling equipment is simple in structure and easy to operate.

The invention discloses a saliva collection and detection device. The saliva collection and detection device comprises a casing, a collection assembly and a collection assembly, wherein the casing comprises an upper casing and a lower casing; the collection assembly is arranged on the lower casing; the detection assembly is arranged in the downstream position of the collection assembly; the collection assembly includes a three-way channel, the three-way channel includes a control channel, an inlet channel and a connecting channel which communicate with one another, the control channel is connected with a control component through the upper casing, and in the three-way channel, a three-way valve is arranged in the communication position of the control channel, the inlet channel and the connecting channel. The saliva collection and detection device has the advantages as follows: through cooperation of the three-way channel with the three-way valve, people can stably collect saliva into the device when performing saliva detection, the operation method is simple, the problem of saliva collection can be avoided, besides, the control component is arranged, saliva enters the device smoothly for detection by using pressure change, and the stability of the device is improved.

The present invention provides an exemplary respirator which may be worn effectively by individuals with beards or other non-conventional facial features such as deep scars. The respirator preferably comprises a means to either seal or plug the user's nose to prevent the user from breathing air in through their nose and also a main housing further comprising a mouth piece, a filter housing, a saliva collector, means for attaching a strap to the main housing, and a strap to keep the mask positioned properly on the user's face. The filter housing is preferably sized to accommodate a removeable dust cartridge and a removeable fume cartridge.

The invention provides a disposable saliva collector with a protection device and convenient for puncture. The disposable saliva collector comprises a self-locking tube cap, a self-locking tube body,a saliva collection cup and a cryopreservation tube; a first ratchet wheel is arranged on the top circumference of the inner wall of the self-locking tube cap; a first connecting part is arranged on the inner side circumference of the self-locking tube cap; a second connecting part matched with the first connecting part is arranged at the upper end of the outer wall of the self-locking tube cap; asecond ratchet wheel matched with the first ratchet wheel is arranged below the second connecting part; a third connecting part is arranged at the lower end of the outer wall of the self-locking tubebody; a diaphragm is arranged on the bottom surface of the inner wall of the self-locking tube body; the saliva collection cup sequentially comprises a collecting cup and a connecting pipe from top to bottom; the connecting pipe comprises a first connecting pipe body and a second connecting pipe body; a fourth connecting part and a piercing mechanism are arranged on the inner side wall of the first connecting pipe body; a fifth connecting part is arranged on the inner wall of the second tube body; and a sixth connecting part is arranged at the top end of the outer wall of the cryopreservationtube. The disposable saliva collector provided with the protection device and convenient for puncture is convenient to operate and safe to use, and the tube cap cannot be unscrewed.