591 results about "Chronic Kidney Diseases" patented technology

The invention relates to compositions of vault complexes containing cell adhesion inhibiting agents, such as a RGD-peptide, and methods of using the vault complexes in the treatment of diseases, such as chronic kidney disease.

Disclosed are compositions containing a VDRA/Vitamin D analog to treat or prevent kidney disease, including chronic kidney disease. The present invention also relates to methods of treating kidney disease by administering to a patient a pharmaceutical composition containing a therapeutically effective amount of a VDRA/Vitamin D analog. Compositions according to the invention include a VDRA/Vitamin D analog and at least one of the following agents: an ACE inhibitor, an angiotensin (II) receptor blocker (ARB) and aldosterone blocker in therapeutically effective amounts to inhibit renin production or inhibit activation of the renin-angiotensin-aldosterone system. Preferred compositions contain paricalcitol with at least one of these other agents. Such combinations can avoid ACE inhibition escape and aldosterone escape with subsequent increase in angiotensin (II) and aldosterone generation.

The invention relates to a method and device for dialysis and or bulk fluid removal by generating a fibrosis chamber within a body cavity and performing dialysis or bulk fluid removal. An implantable medical device is described having a fibrosis chamber and a pump. A dialysis chamber and an optional electrodialysis unit can further be provided. An additional controller uses sensory feedback to regulate the fluid levels by altering the extracellular fluid retention within the fibrosis chamber. This device can be used for the treatment of patients with chronic kidney disease who may also be suffering from cardiorenal syndrome and hypertension.

A system and a method for tracking patients having renal disease, particularly Chronic Kidney Disease (CKD), are provided. The system and method track patients through a common system with multiple healthcare professionals, such as doctors, nurses and the like, having access to the system and updating the system based on information regarding the care, treatment, diagnosis, therapy, or the like provided to the patients. The system and method interface with remote machines and supply chains by a modem, via the internet or by wireless devices. The system and method provide a continuum of care for renal patients, i.e., CKD, peritoneal dialysis (PD), home hemodialyis (HHD), in-center hemodialysis and transplant within a single database associated with the system. The system and method track the access information of PD patients and/or HD patients. Specifically, the system and method track access placement, infections, non-infection related problems, medications and hospitalizations. The system and method may track PD and HD information in one comprehensive module.

The invention relates to nutritional compositions and methods of using these compositions for the treatment of renal disease. More particularly, the invention discloses compositions of vitamins, minerals, amino acids, and/or proteins in amounts that can be used to supplement the nutritional deficiencies observed in patients afflicted with renal disease, renal insufficiency, or end-stage renal disease. The compositions of the invention can also be used as nutritional supplements for patients undergoing dialysis therapy or for patients on a restricted diet. In addition, the compositions can be used in combination or alone as a method of treating or managing a subject in the various stages of chronic renal disease, or throughout disease progression.

The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (CKD), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytokine-1 (MIC-1) in a test body sample from the diseased subject. A method of preventing or reducing the risk of death in a CKD subject which involves removing or inactivating MIC-1 present in the blood, plasma or serum of the subject, is also disclosed.

Disclosed are compositions containing a VDRA/Vitamin D analog to treat or prevent kidney disease, including chronic kidney disease. The present invention also relates to methods of treating kidney disease by administering to a patient a pharmaceutical composition containing a therapeutically effective amount of a VDRA/Vitamin D analog. Compositions according to the invention include a VDRA/Vitamin D analog and at least one of the following agents: an ACE inhibitor, an angiotensin (II) receptor blocker (ARB) and aldosterone blocker in therapeutically effective amounts to inhibit renin production or inhibit activation of the renin-angiotensin-aldosterone system. Preferred compositions contain paricalcitol with at least one of these other agents. Such combinations can avoid ACE inhibition escape and aldosterone escape with subsequent increase in angiotensin (II) and aldosterone generation.

The present invention discloses pharmaceutical-grade ferric organic compounds having enhanced dissolution rate. These ferric organic compounds, including but are not limited to ferric citrate, are useful for treating chronic kidney disease.

This disclosure relates to the treatment of subjects at risk for chronic kidney disease (CKD), having stage one to five CKD, having hyperphosphataemia, susceptible to or suffering from soft tissue calcification associated with CKD, or susceptible to or suffering from hyperparathyroidism, by orally administering a pharmaceutical composition containing a therapeutically effective amount of lanthanum hydroxycarbonate.

A method of treating and preventing secondary hyperparathyroidism in CKD by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin Din a patient by administering 25-hydroxyvitamin D₃ with or without 25-hydroxyvitamin D₂ and, as necessary, 1,25-dihydroxyvitamin D₂ as a Vitamin D hormone replacement therapy.

A method of increasing renal function in a patient operates by stimulation of perivascular sympathetic nerves found in the vicinity of the hepatic portal vein and the hepatic artery. The method can be used as a treatment for renal failure or chronic kidney disease. Alternatively, the method can be used as a prophylactic treatment for preventing contrast-induced nephropathy or any other toxic nephropathy, which can result in renal failure. The perivascular sympathetic nerves can be stimulated by applying energy, such as electrical energy, light, vibration, and ultrasonic vibration, to the perivascular sympathetic nerves. Various methods are described for stimulating the perivascular sympathetic nerves using electrodes that are placed using minimally-invasive techniques.

The invention discloses a knowledge graph-based cross-department early-diagnosis and decision support system for chronic kidney diseases. The system comprises a patient information model establishmentmodule, a patient information model library storage module, a knowledge graph association module, a knowledge graph reasoning module and a decision support feedback module. According to the invention, a patient information model is constructed, and an OMOP CDM standard term system is utilized to construct electronic medical record data of patients into the patient information model with unified concept codes and unified semantic structures; the advantages of a semantic technology in data interaction and expansion are given to play, so the system has better adaptability and expandability to heterogeneous data of different hospitals; and meanwhile, clinical suggestions obtained through knowledge reasoning based on the knowledge graph are originated from clinical guidelines and doctor experience conforming to evidence-based medicine, and reasoning process and suggestion reasons can be traced and acquired by constructing reasoning instances, so the reasoning process and the suggestion reason can be given while clinical suggestions are given, and the credibility of doctors to decision support suggestions is improved.

The invention relates to a urine test paper physiological index quantification identification method based on a cloud platform, and the urine test paper comprises three parts including a two-dimensional code, a standard color card and a test paper. After using the test paper for a urine test, a user takes a photo of the test paper through a mobile phone, a test paper image is automatically acquired and uploaded to the cloud platform, the cloud form integrates an image identification method, the image is processed, and a result is returned to the mobile phone. The identification method comprises the steps: Harris corner detection and calibration are performed on the image; the image space is converted from RGB to CIELAB, the chromatic aberration between the color of the test paper and the color lump of a standard colourimetric card is calculated, a KNN (k-Nearest Neighbour) is adopted to sort the color of the test paper to a corresponding kind in the colourimetric card, and the analysis for test paper measurement index is automatically completed. According to the invention, the method is rapid and simple, problems of ambient light interference and low human eye identification accuracy are avoided, the cost is low, in addition, the method can be used for screening patients with early chronic kidney disease and patients with diabetes, and the risk of diseases is reduced.

The invention provides novel compounds having the general formula (I)

wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, A¹, A² and A³ are as described herein, compositions including the compounds and methods of using the compounds. These compounds are useful for therapy or prophylaxis in a mammal, and in particular as aldosterone synthase (CYP11B2 or CYP11B1) inhibitors for the treatment or prophylaxis of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrome.

The present invention relates to oral compositions which are useful for nutrient supplementation. The dietary supplements and pharmaceutical products and methods of the present invention are particularly useful in the treatment of patients in various stages of chronic kidney disease and supplementing levels of physiological anti-oxidants, vitamins, and minerals in subjects requiring dialysis therapy.

This invention is in the field of medicinal chemistry and relates to novel compounds, and pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarring/wound healing abnormalities, post operative adhesions, and reactive fibrosis. The invention also relates to methods of using the compounds and pharmaceutical compositions of this invention to treat fibrotic conditions.

The invention provides a conjugate comprising a biomolecule linked to a fatty acid via a linker wherein the fatty acid has the following Formulae A1, A2 or A3:

Provided herein are specific doses of, and dosing regimens for, using a HIF prolyl hydroxylase inhibitor in treating or preventing anemia, such as anemia secondary to or associated with chronic kidney disease, anemia associated with or resulting from chemotherapy, or anemia associated with AIDS.