The invention relates to a medicinal composition containing paricalcitol. The medicinal composition is composed of paricalcitol, alcohol, propanediol and water for injection. A preparation method of the medicinal composition comprises the following steps: uniformly mixing alcohol and propanediol, adding with 0.5% (w/v) activated carbon, carrying out adsorption for 15-75 min, carrying out decarburization, adding with paricalcitol, carrying out stirring so that the dissolving is complete, adding with the water for injection, carrying out uniform stirring, carrying out filling, carrying out sealing, and carrying out sterilization for 12 min at 121 DEG C. The invention further relates to a method for reducing the degradation impurities of the medicinal composition containing paricalcitol, which comprises the step of encapsulating the composition in an ampoule bottle, wherein the residual oxygen quantity of gas in the ampoule bottle is controlled to be 0.32-2 ml. The product is simple and rapid in preparation, no precipitation of raw materials occurs, the long-time stirring for redissolving of the materials is not needed, meanwhile, the residual oxygen quantity of the gas in an injection container is controlled, so that the content of the degradation impurity PCL-9 is reduced to be 0.1% or below after illumination, and thus the safety of the product is good.