The invention discloses an environmental-friendly and efficient preparation method of a
quinolone compound. According to the adopted technical scheme, the environmental-friendly and efficient preparation method comprises the following steps: putting an intermediate 1 (I) in a reactor, dropwise adding an intermediate 2 (II) at a
room temperature, and mixing and stirring uniformly under the condition without
solvent to carry out
solvent-free
hydroamination; after a detection reaction is completed, carrying out
chromatography on reaction liquid through a silicagel column, concentrating through reduced pressure
distillation to obtain a yellow oily intermediate 3 (III); then putting the intermediate 3 (III) in the reactor, directly adding a catalyst, heating for
dissolution while stirring to carry out an
intramolecular cyclization reaction; after the detection reaction is completed,
quenching the reaction by using
ice water, extracting, concentrating and recrystallizing to obtain a target compound 4 (IV). The preparation method of the
quinolone compound disclosed by the invention is environmental-friendly, efficient, simple, convenient and safe to operate, and the produced
quinolone compound is low in cost.