148 results about "Glutaric anhydride" patented technology

An acrylic resin film, in which acrylic elastic particles are mixed with an acrylic resin containing glutaric anhydride units, has a total light transmittance of 91% or more, a haze value of 1.5% or less, a folding endurance value (times) of 20 or more, and a heat shrinkage rate of less than 5% at least in either the machine direction or the transverse direction in a heat shrinkage test.

Provided is a resin composition containing a thermoplastic acrylic resin and an ultraviolet absorber (UVA). While this resin composition has excellent heat resistance because of its high glass transition temperature, foaming and bleed-out can be suppressed and the problems arising from the evaporation of the UVA can be reduced even during the molding of the resin composition at a high temperature. The resin composition is a thermoplastic resin composition containing a thermoplastic acrylic resin and an ultraviolet absorber having a molecular weight of 700 or more, and having a glass transition temperature of 110° C. or higher. It is preferable that the ultraviolet absorber has a hydroxyphenyltriazine skeleton. It is preferable that the acrylic resin has a ring structure in its main chain. The ring structure is, for example, at least one selected from a lactone ring structure, a glutaric anhydride structure, a glutarimide structure, an N-substituted maleimide structure, and a maleic anhydride structure.

In a nonaqueous electrolyte secondary battery according to an embodiment of the invention, a nonaqueous electrolyte contains: a tertiary carboxylate ester represented by the following general formula (1) in an amount of a range of 3% by mass or more and 80% by mass or less based on the total mass of the nonaqueous solvent:where R1, R2, R3, R4 represent a (C1 to 4) alkyl group, respectively, and one or more acid anhydride selected from succinic anhydride, glutaric anhydride, and glycolic anhydride in an amount of a range of 0.1% by mass or more and 5% by mass or less based on the total mass of the nonaqueous electrolyte. By containing such a constitution, in other words, by containing a nonaqueous solvent capable of stabilizing the coating film of the negative electrode, a nonaqueous electrolyte secondary battery in which not only can satisfactory cycle performance and retention characteristics be obtained, but also the overcharging performance is largely improved, can be provided.

The present invention concerns a reactive carrier that forms no by-products during melt injection of polymer into articles such as sheets, films, fibers and containers. The reactive carrier is used to mix additives into the polymer resin. More particularly, the invention relates to the use of one or more cyclic anhydrides or substituted cyclic anhydrides as the reactive carrier. The polymer can be polyester or polyamide. Suitable cyclic anhydrides are those with a melt point of less than the polyester or polyamide, preferably less than about 160° C., and more preferably less than about 125° C. Most preferable are cyclic anhydrides with a melt point less than about 100° C. and especially suitable are those that are liquid at room temperature (25° C.). The cyclic anhydride may be selected from the group of succinic anhydride, substituted succinic anhydride, glutaric anhydride, substituted glutaric anhydride, phthalic anhydride, substituted phthalic anhydride, maleic anhydride, substituted maleic anhydride, or mixtures of two or more of these.

A disinfectant with hydrogen peroxide bactericidal activity is composed of A, B, C and D component. If the solute is metered by 100%, its weight account proportion of mixed solution A:B:C:D=5-100:1-50:1-100:1-1000 obtained through hydrogen cation resin exchanged and filtered, wherein A is hydrogen peroxide; B is form one or more of glutaric anhydride, adipic anhydride, succinic anhydride, acetic anhydride, propionic anhydride, benzoic anhydride and phthalic anhydride; C is from one or more of sulfuric acid, phosphoric acid, salicylic acid, tartaric acid, citric acid, dipicolinic acid, sorbic acid, acetic acid, glutaric acid, oxalic acid, succinic acid, acetic acid, propionic acid, benzoic acid, and phthalic acid; D is from one or more of ethanol, ethylene glycol, isopropanol, glycerol, and polyvinyl alcohol. It is a good stability, strong bactericidal, fungicidal spectrum-efficient disinfectant.

A disinfectant able to increase the bactericiding activity of hydrogen peroxide is prepared from the aqueous solution of hydrogen peroxide, the activating agent chosen from the complex of metallic ion (Fe, Cu, Ag or Mg), the anhydride of acetic acid, propionic acid, butanedioic acid, etc and the stabilizer chosen from organic acid and inorganic acid through proportional mixing, and controlling pH=0.5-4 and temp to be lower than 100 deg.C. Its advantages are high bactericiding power, broad spectrum and high stability.

The invention provides a novel method for synthesizing ezetimibe. The method uses fluorobenzene as an initial raw material to react with glutaric anhydride and 4(s)-4-phenyl oxazolidone in sequence under the action of a catalyst, and generates the ezetimibe via condensation, cyclization, deprotection, reduction and other conventional methods after carbonyl is protected by thiol. The method has the advantages of high yield and few side reactions, and is applicable to industrial production.

A process for continuously producing a thermoplastic copolymer, in which a copolymer (A) containing unsaturated carboxylic acid alkyl ester units and unsaturated carboxylic acid units is produced and in succession heat-treated to perform intramolecular cyclization reaction by dehydration and / or dealcoholization reaction, for producing a thermoplastic copolymer (B) containing glutaric anhydride units and the unsaturated carboxylic acid alkyl ester units. The obtained copolymer is excellent in heat resistance and colorless transparency and very small in foreign matter content.

A thermoplastic polymer containing glutaric anhydride units of the following general formula (1) and having an absorbance at a wavelength of 280 nm of at most 0.5 (the absorbance is a value of the polymer film having a thickness of 100 μm, measured with a UV-visible spectrophotometer) and a glass transition temperature of not lower than 130° C. has high-level colorless transparency and good heat resistance, moldability and dwell stability. wherein R1 and R2 are the same or different and each represents a hydrogen atom or an alkyl group having from 1 to 5 carbon atoms.

The present invention concerns a reactive carrier that forms no by-products during melt injection of polymer into articles such as sheets, films, fibers and containers. The reactive carrier is used to mix additives into the polymer resin. More particularly, the invention relates to the use of one or more cyclic anhydrides or substituted cyclic anhydrides as the reactive carrier. The polymer can be polyester or polyamide. Suitable cyclic anhydrides are those with a melt point of less than the polyester or polyamide, preferably less than about 160° C., and more preferably less than about 125° C. Most preferable are cyclic anhydrides with a melt point less than about 100° C. and especially suitable are those that are liquid at room temperature (25° C.). The cyclic anhydride may be selected from the group of succinic anhydride, substituted succinic anhydride, glutaric anhydride, substituted glutaric anhydride, phthalic anhydride, substituted phthalic anhydride, maleic anhydride, substituted maleic anhydride, or mixtures of two or more of these.

The present invention relates to a thermoplastic resin composition which contains a thermoplastic polymer (A) containing a glutaric anhydride-containing component shown in the following general formula (1), where R1 and R2 are the same or different and each represents a hydrogen atom or an alkyl group having 1 to 5 carbon atoms, and a rubber-containing polymer compound (B), and satisfies the following conditions of (I) and / or (II), (I) a total light transmittance per 2 mm of the thickness of the thermoplastic resin composition is more than 90%, (II) a weight-average molecular weight of a thermoplastic polymer (A) is from 30,000 to 150,000 and a glass transition temperature is at least 130° C. According to the present invention, a thermoplastic composition having high heat resistance, superior mechanical properties, colorless transparency, optical isotropy and moldability, as well as solvent resistance, is provided.

The invention provides a preparation method for a physiological cooling agent--menthyl glutarate. The menthyl glutarate is prepared by reacting menthol with glutaric anhydride in the presence of an acidic catalyst, and a reaction equation is described in the specification, wherein a weight ratio of the acidic catalyst to the menthol is in a range of 0.01 to 0.1, a weight ratio of the glutaric anhydride to the acidic catalyst is 0.6667: 1 to 1: 1, the content of monomenthyl glutarate in an obtained menthyl glutarate mixture is 55 to 75%, the content of dimenthyl glutarate in the obtained menthyl glutarate mixture is 25 to 45%, the acidic catalyst is one or a mixture of two selected from the group consisting of sulfuric acid, phosphoric acid, p-toluenesulfonic acid, oxalic acid, methanesulfonic acid and an acidic resin, a non-polar solvent like hexane, heptane, cyclohexane, toluene and benzene is used in the reaction, reaction temperature is 50 to 110 DEG C, and reaction time is 1 to 15 h. The preparation method provided by the invention needs short reaction time and can prepare a menthyl glutarate product with good fragrance and taste.

A vehicle part cover including a methacrylic-based resin (I) having a weight average molecular weight measured by gel permeation chromatography (GPC) of 65,000 to 300,000,the methacrylic-based resin (I) comprising:50 to 97% by mass of a methacrylate monomer unit (A);3 to 30% by mass of a structural unit (B) having a ring structure in its main chain, and being at least one selected from the group consisting of a maleimide-based structural unit, a glutaric anhydride structural unit, a glutarimide-based structural unit, and a lactone ring structural unit; and0 to 20% by mass of another vinyl monomer unit (C) that is copolymerizable with a methacrylate monomer.

The invention discloses a preparation method and applications of carboxylation chitosan. The preparation method comprises following steps: a dimethylsulfoxide solution of glutaric anhydride is delivered into a sealed reactor, and is heated, chitosan is added for reaction, an obtained product is reacted in sodium hydroxide solution so as to obtain carboxylation chitosan; carboxylation chitosan is dissolved in a solid acid solution, calcium chloride is added for dissolving, an obtained mixture is subjected to spray drying so as to obtain carboxylation chitosan hemostatic particles; carboxylation chitosan is dissolved in the solid acid solution, calcium chloride is added for dissolving, the obtained mixture is subjected to freeze drying so as to obtain carboxylation chitosan hemostatic sponge; carboxylation chitosan is dissolved in an acid solution, an obtained mixed solution is injected into a mould, the mould is sealedly coated with a one-way permeable membrane, and is immersed in an alkaline medium so as to obtain chitosan gel, the obtained chitosan gel is washed with deionized water until pH value reaches 7, and is immersed in a calcium chloride solution for crosslinking, an obtained product is collected, washed, immersed in a glycerine solution, collected, and drained, is added into absolute ethyl alcohol for single-surface steaming, and is dried so as to obtain carboxylation chitosan hemostatic membranes.

The invention belongs to the technical field of powder coating, and particularly relates to a low-temperature curing polyester resin for an HAA system, and further discloses a preparation method thereof, and application thereof in preparing an HAA system powder coating. The low-temperature curing polyester resin provided by the invention is formed by performing copolymerization on highly-active monomer raw materials such as dimethyl isophthalate, phenylenediacetic acid, glutaric anhydride, 2-ethyl-1,3-hexanediol, butynediol, cyclohexane-1,2-dicarboxylic diglycidyl ester, estradiol and citric acid, the acid value of the finally obtained polyester resin is 30 to 35mgKOH / g, the softening point is 95 to 110 DEG C, and the activity of the polyester resin is high; furthermore, as the softening point is lowered, the fully curing of the polyester resin under the condition of 140 DEG C / 20min can be realized, energy consumption in the powder coating technology is greatly reduced, and the performance of various aspects of the low-temperature curing polyester resin can better reach the using requirement of common HAA-cured polyester resin, and excellent combination property is realized.

A hardcoat laminate including: a support formed from a thermoplastic resin composition; and a hardcoat layer formed from a hardcoat layer forming coating composition, wherein the thermoplastic resin composition contains a polymer having a lactone ring unit or a glutaric anhydride unit, and the hardcoat layer forming coating composition contains at least a component (a), a component (b) and a component (c) and contains substantially no organic solvent: (a) a curable compound having three or more polymerizable groups within one molecule, (b) a polymerization initiator, and (c) a diluent having from one to three polymerizable groups within one molecule.

The invention provides a preparation method for an artificial antigen of theophylline. The preparation method comprises the following steps of: (a) preparing and detecting a hapten: reacting 5,6-diamido-1,3-dimethylurea pyrimidine (1) with glutaric anhydride to obtain the hapten containing carboxyl; (b) preparing and detecting the artificial antigen: combining the hapten with bovine serum albumin (BSA) by utilizing a carbodiimide method, so as to prepare the artificial antigen of the theophylline, namely theophylline-bovine serum albumin. According to the preparation method, the prepared artificial antigen of the theophylline can be subjected to animal immunization to obtain corresponding theophylline antibodies and can be used for researching various theophylline immunoassay methods, and a relatively convenient, fast and accurate way is provided for the detection of the theophylline.

The invention discloses a preparation method for 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one. The method comprises the following steps: (1) mixing and reacting glutaric anhydride and methanol to obtain mixture 1 which contains monomethyl glutarate and glutaric acid; (2) mixing the mixture 1 with dichloromethane and rinsing an obtained mixture with an saturated sodium chloride solution to obtain monomethyl glutarate; (3) mixing and reacting monomethyl glutarate with thionyl chloride to obtain methyl 4-(chlorofomyl)butyrate; and (4) mixing methyl 4-(chlorofomyl)butyrate with (S)-4-phenyloxazolidinone at a temperature of 0 to 5 DEG C within 3 to 3.5 h and carrying out condensation to obtain 3-(5-methoxy-1,5-dioxopenyl)-(4S)-phenyloxazolidin-2-one.

The invention relates to a preparation method of small molecular hydrogel precursor molecules based on folic acid-anticancer drugs. The obtained compound is prepared into small molecular hydrogel by reducing disulfide bonds using reducing agents (glutathione and dithiothreitol). Specifically, the preparation method comprises the following steps of: firstly, synthesizing folic acid connected small peptides by a solid phase synthesis method, then derivatizing an anticancer drug (taxol, camptothecin, hydroxycamptothecine and the like) by butanedioic anhydride or glutaric anhydride to remove one carboxyl group, and connecting the folic acid connected small peptides with the derivatized anticancer drug. The precursor molecules not only have a targeting effect, but also have good solubility and are capable of self assembling into small molecular hydrogel by reduction of the disulfide bonds. The novel transmission system of the hydrophobic anticancer drug established by the invention not only greatly improves the solubility of the hydrophobic anticancer drug in water, but also is capable of targeting tumor tissues, thus reducing toxic side effects.

The invention discloses a novel technical method for synthesizing ezetimibe (a compound 1), and belongs to the field of organic chemical medical synthesis. The method comprises the following steps: synthesizing a (3R, 4S)beta-lactam ring of a key intermediate (a compound 9) by taking p-anisaldehyde, 4-fluoroaniline and glutaric anhydride as main raw materials; and reducing and hydrolyzing the compound to obtain ezetimibe. The method disclosed by the invention adopts simply and easily-available materials, and is less in synthesis steps, and stable in process; a chiral four-membered ring of the key intermediate is directly constructed by virtue of one-step reaction to obtain an important intermediate (3R, 4S)-1-(4- fluorophenyl)-3-[(3S)-3-]4-fluorophenyl)-3-carbonyl propyl]-4-(4-methoxypheyl)-2-azetidinone (a compound 9); a target enantiomer proportion in the product is high, post-treatment operation is simple, and industrial large-scale production is easy to realize.

The invention discloses a method for preparing high-purity delta decalactone. The method for preparing the high-purity delta decalactone comprises the following steps of: adding glutaric anhydride serving as a raw material and a Grignard reagent of halogenated pentane to obtain a 5-oxodecanoic acid intermediate; and under alkalic condition, reducing the 5-oxodecanoic acid intermediate by using sodium borohydride and performing acidification cyclization to obtain the high-purity delta decalactone. The raw materials, such as the glutaric anhydride and the halogenated pentane, in the method are commercial products; and the reaction materials are readily available and low in cost. The method for preparing the high-purity delta decalactone has fewer steps and is simple in operation and easy to industrialize; the yield of the products is high; the mole yield of the products reaches 70 percent; and the purity of the products reaches over 99 percent.

The invention discloses a synthesis method for 3,3',4,4'-biphenyltetracarboxylic acid. The synthesis method comprises the following steps: with 4,4'-dimethyl biphenyl as a starting raw material, subjecting the 4,4'-dimethyl biphenyl and cyclic anhydride as shown in a formula I which is described in the specification to a Friedel-Crafts acylation reaction so as to obtain an intermediate II, and carrying out an oxidation reaction so as to obtain the 3,3',4,4'-biphenyltetracarboxylic acid, wherein the cyclic anhydride as shown in the formula I is selected from the group consisting of succinic anhydride, glutaric anhydride, adipic anhydride and maleic anhydride. The method provided by the invention does not need an expensive catalytic system, so the production cost of synthesizing the 3,3',4,4'-biphenyltetracarboxylic acid is greatly reduced; the method provided by the invention is simple to operate, mild in reaction conditions, less in three wastes, easy in wastewater treatment and friendly to the environment; and the raw material, namely the 4,4'-dimethyl biphenyl adopted in the method provided by the invention is a byproduct of a medical intermediate, namely sartan biphenyl, and theproduction amount of the byproduct accounts for about 10% of the production amount of the sartan biphenyl, so the waste can be turned into treasure after the byproduct is applied to synthesis of the3,3',4,4'-biphenyltetracarboxylic acid.

A process for continuously producing a thermoplastic copolymer, in which a copolymer (A) containing unsaturated carboxylic acid alkyl ester units and unsaturated carboxylic acid units is produced and in succession heat-treated to perform intramolecular cyclization reaction by dehydration and / or dealcoholization reaction, for producing a thermoplastic copolymer (B) containing glutaric anhydride units and the unsaturated carboxylic acid alkyl ester units. The obtained copolymer is excellent in heat resistance and colorless transparency and very small in foreign matter content.

The invention provides a preparation method of high-quality agar. Glutaric anhydride is used for esterification modification of agar powder, thus increasing use value of agar. The process of the invention is simple, and helps improve transparency of the prepared high-quality agar significantly compared with the original agar, and also helps enhance viscosity of the agar. The modified high-qualityagar has high gel strength.

The invention discloses a method for preparing 4-(4-fluorobenzoyl) butyric acid. The method comprises the following steps: with the protection of an inert gas, dispersing fluobenzene and treated aluminum trichloride into an organic solvent to form a dispersion system, subsequently dropwise adding glutaric anhydride into the dispersion system, reacting at 10-30 DEG C after glutaric anhydride is added, and treating after the reaction is completed so as to obtain 4-(4-fluorobenzoyl) butyric acid. By controlling the moisture content and the grain fineness of aluminum trichloride, the conversion rate of the reaction is greatly improved, the production cost is lowered, and high industrial production operability is achieved.