3 results about "Glutaric anhydride" patented technology

The application discloses a compound for degrading a target protein in a ubiquitin-proteasome system and a preparation method and application thereof, and a structural general formula of the compound is shown as formula I: R a -linker-SP-linker-R b Formula I; wherein, R a is an E3 ubiquitin ligase ligand; R b is a target protein ligand; SP is a sulfonyl pyridine, a chemical structural formula is shown as formula II; and linker is selected from succinic anhydride, glutaric anhydride, -CO-R 1 -CO- or -NH-R 2 -CO-, wherein, R 1 and R 2 are each independently selected from any substituted C1-C6 alkylene. The compound SD02 for degrading a target protein in the ubiquitin-proteasome system of the application significantly induces polyubiquitination of a STING protein, the SD02 effectively degrades the STING protein through the ubiquitin-proteasome system, in addition, the SD02 shows a dose-dependent reduction of phosphorylation levels of TBK1 and IRF3, can reduce mRNA levels of interferon-related genes induced by SATE-3', 3'-c-di-dAMP, and the SD02 has a cell growth inhibition effect on THP1, U937 and U2OS cells, and the SD02 does not hinder cell proliferation even at a high concentration.

Disclosed are an electrolytic solution for lithium secondary batteries capable of improving lifespan characteristics of a lithium secondary battery under a high voltage condition and a lithium secondary battery including the same. The electrolytic solution may includes a lithium salt, a solvent, and a functional additive. In particular, the functional additive includes a high-voltage additive including a first high-voltage additive, e.g., hexafluoroglutaric anhydride, and a second high-voltage additive, e.g., fluoroethylene carbonate.

The application belongs to the field of chemical synthesis, and particularly relates to a preparation method of 5-benzoyl dihydrofuran-2(3H)-one and derivatives thereof. The preparation method is as follows: five-membered ring, six-membered ring aromatic and heterocyclic compounds, and substituted glutaric anhydride are used as raw materials, aluminum chloride is used as a catalyst, a solvent is simply distilled out, and phenyl dihydrofuran-2(3H)-one and derivatives are prepared by one-pot method with iodobenzene acetate as an oxidant. The reaction condition is simple, the reaction temperature is 40-60 DEG C, no noble metal catalyst is used in the scheme disclosed in the application, no heavy metal residue is caused, the raw materials used are commercial products, the oxidant and the catalyst are relatively inexpensive and easy-to-obtain substances, the reaction operation is simple, and the reaction product is easy to purify and the post-treatment is convenient.