17 results about "Glutaric anhydride" patented technology

The invention relates to an aliphatic copolyester elastomer and a preparation method thereof, and belongs to the field of high polymer materials. The elastomer is prepared through a series ring-opening copolymerization reaction of epoxide and cyclic anhydride, and the method comprises the following steps: under the action of a metal-free catalyst (a phosphazene ligand P1-tert-octyl / triethyl boron system) and an initiator (terephthalyl alcohol), carrying out a series ring-opening copolymerization reaction on epoxide and cyclic anhydride, the preparation method comprises the following steps: reacting epoxide (such as epoxypropane and allyl glycidyl ether) with aliphatic anhydride (such as glutaric anhydride) in a xylene solvent to generate a polyester prepolymer retaining an active end; adding a second group of epoxide (such as cyclohexene oxide) and anhydride (such as tetrahydrophthalic anhydride and norbornene dianhydride), continuously reacting to form a block copolymer, and then crosslinking. The material performance can be regulated by changing the monomer combination, the atom economy is high, and the raw materials can be produced on a large scale. The process is simple and environment-friendly, and a new choice is provided for application of the degradable elastomer in the fields of medical treatment, environmental protection and the like.

The invention provides polyester resin for a transparent powder coating with excellent adhesive force and leveling as well as a preparation method and application of the polyester resin, and belongs to the technical field of powder coatings. The polyester resin is mainly prepared by taking diethylenetriamine pentaacetic acid, triethyl chlorosilane, 1, 6-hexanediol, N, N-diisopropylethanolamine, 2, 2-dimethyl propanol, neopentyl glycol, 3, 3-tetramethylene glutaric anhydride, 1, 4-cyclohexanedimethanol and the like as raw materials through polymerization. The obtained polyester resin chain segment has many branched structures, the number of amino groups and ester groups in the branched structures is large, the softening point is low, the low-temperature melting fluidity is good, the transparency is high, the adhesive force with a base material is good, then high-functionality diethylenetriamine pentaacetic acid is adopted for carboxyl end capping, the terminal carboxyl functionality is high, the curing activity is high, and the curing effect is good. After being cured with E-12 epoxy resin at low temperature, a coating film is good in leveling property and high in transparency, and can be used in the fields of thermosensitive base materials which are not easy to adhere, such as thin glass materials and the like.

The invention discloses a water-based bisphenol A type epoxy resin based cyclic carbonate emulsion, a preparation method thereof and a water-based non-isocyanate polyurethane coating. The preparation method comprises the following steps: adding hydroxymethyl dioxolane ketone and anhydride into a four-neck flask, adding a catalyst, and reacting to obtain a cyclic carbonate intermediate; adding bisphenol A epoxy resin into the cyclic carbonate intermediate, and stirring and heating; and adding glutaric anhydride, stirring for reaction, cooling, and neutralizing and emulsifying to obtain the cyclic carbonate emulsion. Mixing the prepared cyclic carbonate emulsion with a diamine curing agent to prepare a film, and curing to obtain the water-based non-isocyanate polyurethane coating. The epoxy resin-based cyclic carbonate emulsion prepared by the invention has excellent storage stability, and a water-based non-isocyanate polyurethane coating prepared from the epoxy resin-based cyclic carbonate emulsion has high hardness and excellent impact resistance and chemical resistance, can replace a polyurethane coating prepared from traditional isocyanate, and is a green and environment-friendly material with excellent performance.

The invention belongs to the technical field of biological detection, and particularly relates to an immunodetection reagent for blood virus screening and a preparation method of the immunodetection reagent. The immunodetection reagent comprises the following raw materials in parts by weight: 100 parts of a capture reagent, 300 parts of a sealing agent, 300 parts of a cracking agent, 1 part of an HCV recombinant antigen, 1 part of an anti-HCVcAg monoclonal antibody, 0.2-0.6 part of hydroxymethylcoumarin, 10 parts of BSA, 2-6 parts of glutaric anhydride, 4-8 parts of TEOS and 100 parts of a PBS buffer solution. According to the present invention, the silica microsphere with the HCV recombinant antigen and the anti-HCVcAg monoclonal antibody coupled on the surface and the hydroxymethylcoumarin signal molecule loaded inside is constructed, and the HCV antigen and the HCV antibody in the serum are specifically recognized so as to achieve the efficient diagnosis and detection of the HCV infection in the whole cycle;

A resin composition containing 30 to 85 parts by mass of an acrylic resin (A) and 15 to 70 parts by mass of an aromatic vinyl resin (B), wherein the acrylic resin A contains 60 to 95% by mass of (meth)acrylic monomer units and 5 to 40% by mass in total of at least one selected from the group consisting of glutaric anhydride units, glutarimide units, N-substituted maleimide units, and lactone ring units, and the aromatic vinyl resin (B) contains 55 to 93% by mass of aromatic vinyl monomer units and 7 to 45% by mass of N-substituted maleimide units. A plate-shaped molded article and a multilayered article are provided.

The invention belongs to the technical field of adhesives, and particularly relates to polypolysiloxane and a preparation method thereof, and ACF glue and a preparation method thereof. The preparation method of the multi-element polysiloxane comprises the following steps: carrying out ring opening polymerization on octamethylcyclotetrasiloxane, and reacting with vinyl dimethyl ethyoxyl silane to obtain polysiloxane containing double bonds; the preparation method comprises the following steps: reacting polysiloxane containing double bonds, 2, 4, 6, 8-tetramethyl-2, 4-bis (3, 3, 3-trifluoropropyl) cyclotetrasiloxane and 1, 1, 1, 3, 5, 5-hexamethoxy trisiloxane under the action of a platinum catalyst to obtain fluorine-containing polysiloxane; the preparation method comprises the following steps: firstly hydrolyzing fluorine-containing polysiloxane and N-aminoethyl-3-aminopropyl methyl dimethoxy silane, and then reacting under the action of an acid catalyst to obtain fluorine-containing amino polysiloxane; the fluorine-containing amino polysiloxane and glutaric anhydride are subjected to acylation reaction, and the fluorine-containing amino polysiloxane is obtained. The polypolysiloxane can prolong the service life of the ACF adhesive in a humid and hot environment, and improves the bonding strength of an adhesive layer to a base material.

The invention discloses a preparation method of medicinal 6-arm-polyethylene glycol-succinimide glutaric acid ester (amido bond), which comprises the following steps: reacting 6-arm-polyethylene glycol-amino with glutaric anhydride to obtain a reaction solution 1; adding an organic solvent B into the reaction liquid 1, stirring, pulping, filtering and drying to obtain 6-arm-polyethylene glycol-glutaric acid (amido bond); mixing 6-arm-polyethylene glycol-glutaric acid (amido bond) with a condensing agent, dropwise adding organic alkali, and reacting to obtain reaction liquid 2; adding N-hydroxysuccinimide, and reacting to obtain a reaction solution 3; concentrating under reduced pressure, dropwise adding n-hexane into the filtrate to separate out solid, stirring and pulping to obtain pulp; and filtering, washing a filter cake with n-hexane, and drying to obtain the medicinal 6-arm-polyethylene glycol-succinimide glutaric acid ester (amido bond). The method has the advantages of mild reaction conditions, high reaction rate, few byproducts and high yield, the content is more than 99.0%, the acid value is less than 0.10, and the quality indexes all meet the standards of pharmaceutical enterprises.

The application discloses a compound for degrading a target protein in a ubiquitin-proteasome system and a preparation method and application thereof, and a structural general formula of the compound is shown as formula I: R a -linker-SP-linker-R b Formula I; wherein, R a is an E3 ubiquitin ligase ligand; R b is a target protein ligand; SP is a sulfonyl pyridine, a chemical structural formula is shown as formula II; and linker is selected from succinic anhydride, glutaric anhydride, -CO-R 1 -CO- or -NH-R 2 -CO-, wherein, R 1 and R 2 are each independently selected from any substituted C1-C6 alkylene. The compound SD02 for degrading a target protein in the ubiquitin-proteasome system of the application significantly induces polyubiquitination of a STING protein, the SD02 effectively degrades the STING protein through the ubiquitin-proteasome system, in addition, the SD02 shows a dose-dependent reduction of phosphorylation levels of TBK1 and IRF3, can reduce mRNA levels of interferon-related genes induced by SATE-3', 3'-c-di-dAMP, and the SD02 has a cell growth inhibition effect on THP1, U937 and U2OS cells, and the SD02 does not hinder cell proliferation even at a high concentration.

Disclosed are an electrolytic solution for lithium secondary batteries capable of improving lifespan characteristics of a lithium secondary battery under a high voltage condition and a lithium secondary battery including the same. The electrolytic solution may includes a lithium salt, a solvent, and a functional additive. In particular, the functional additive includes a high-voltage additive including a first high-voltage additive, e.g., hexafluoroglutaric anhydride, and a second high-voltage additive, e.g., fluoroethylene carbonate.

A composite anhydride modified UV-curable epoxy acrylate, and a preparation method therefor and the use thereof. The preparation method comprises the following steps: heating glutaric anhydride, maleic anhydride, phthalic anhydride, acrylic acid, hydroxyethyl acrylate, epoxy resin, part of a catalyst, and part of a polymerization inhibitor to 75°C-80°C with stirring and maintaining the temperature for 0.8-1.2 h; then, increasing the temperature in stages, adding the remaining catalyst and polymerization inhibitor in batches, and finally increasing the temperature to 115°C-125°C and reacting for 4-5 h to obtain the composite anhydride modified UV-curable epoxy acrylate. The preparation method is low in terms of price and low in terms of product cost, does not use any solvent in the reaction process, and reduces VOC emissions. The prepared epoxy acrylate has high functionality, and good hardness, adhesion, flexibility, impact resistance and chemical resistance after film formation.

The present application relates to a kind of high-hardness polyester resin for powder coating and its preparation method, which is obtained by polymerization using alkaline lignin, 1,4-dioxane, glutaric anhydride, dimethylbenzene, terephthalic acid, neopentyl glycol, triethylene glycol, adipic acid, etc. as main raw materials. The polyester resin contains high-functionality alkaline lignin structure in its molecule, which is rigid and has high hardness and excellent scratch resistance after curing with TGIC. The polyester resin comprehensively utilizes the effective components of alkaline lignin, a by-product of papermaking, providing an effective way for the high-value-added comprehensive utilization of alkaline lignin, a by-product of papermaking.

The invention discloses a water-retaining agent for slow release of a fertilizer and a preparation method of the water-retaining agent, and relates to the technical field of biology. The method comprises the following steps: sequentially carrying out alkaline extraction and acidic extraction on wheat straw powder to obtain wheat straw cellulose; mixing the wheat straw cellulose with an alkaline compound and an acidic compound, and carrying out a first reaction to obtain a first intermediate product; mixing urea, glutaric anhydride and a second solvent, and carrying out a second reaction to obtain a second intermediate product; mixing the second intermediate product with trimethylolpropane triglycidyl ether, and carrying out a third reaction to obtain a third intermediate product; and mixing the third intermediate product, the first intermediate product and sodium alginate, and carrying out a fourth reaction to obtain the water-retaining agent for slow release of the fertilizer. The water-retaining agent for slow release of the fertilizer, which is prepared by the method provided by the invention, has excellent mechanical properties, water absorption and water retention functions and a nitrogen fertilizer slow release function, and has a wide application prospect in the field of agriculture.

The invention discloses a preparation method of a bis (lauramide glutamine) lysine sodium compound, which comprises the following steps: adding lauramide glutaric anhydride and lysine into a reaction flask filled with water, adjusting the solution in the reaction flask to an alkaline environment by using a sodium hydroxide solution, heating and refluxing, and after the reaction is complete, cooling to room temperature to obtain the bis (lauramide glutamine) lysine sodium compound. And continuing to adjust the reaction solution in the reaction bottle to an alkaline environment by using a proper amount of sodium hydroxide solution to finally obtain the target compound bis (lauramide glutamine) sodium lysine. The one-step synthesis is adopted, so that the raw material conversion rate, the product purity and the product quality are greatly improved, and the market competitiveness is provided.

The invention belongs to the technical field of flavors and fragrances, and particularly relates to a synthetic method of delta-lactone. The method comprises the following steps: heating glutaric acid and anhydride to a reflux state, carrying out vacuum distillation to remove redundant acetic anhydride and generated acetic acid, and cooling to obtain solid glutaric anhydride. The method comprises the following steps: adding a solvent and glutaric anhydride, adjusting to a first reaction temperature, dropwise adding a Grignard reagent, quenching by using acid after the reaction is finished, removing the solvent through reduced pressure distillation, extracting by using dichloromethane, adding anhydrous sodium sulfate for drying, and removing dichloromethane through normal pressure distillation to obtain the 5-oxocarboxylic acid. 5-oxocarboxylic acid and a catalyst are added into the high-pressure kettle, the temperature is adjusted to a second reaction temperature, a delta-lactone crude product is synthesized through hydrogenation, and a delta-lactone product is obtained through rectification and purification. The raw materials and reagents are all industrial basic raw materials and are low in price. Reaction conditions are simple, production operation is simple, and industrialization is easy. And meanwhile, explosive substances are not generated in the production process, the production safety is high, and environmental protection is achieved.

The invention discloses a synthesis process of ingavirin, which comprises the following operation steps: reacting histamine dihydrochloride with alkali in an alcohol solvent for alkalization, removing separated sodium chloride, and then adding glutaric anhydride for reaction to generate ingavirin; the alcohol solvent is a low-carbon alcohol solvent, and the reaction temperature is controlled in a range from 0 DEG C to an alcohol boiling point temperature. According to the present invention, the brand new ingavirin synthesis process is adopted, and the advantages of process simplification, yield increase and pollution reduction are provided.

The application belongs to the field of chemical synthesis, and particularly relates to a preparation method of 5-benzoyl dihydrofuran-2(3H)-one and derivatives thereof. The preparation method is as follows: five-membered ring, six-membered ring aromatic and heterocyclic compounds, and substituted glutaric anhydride are used as raw materials, aluminum chloride is used as a catalyst, a solvent is simply distilled out, and phenyl dihydrofuran-2(3H)-one and derivatives are prepared by one-pot method with iodobenzene acetate as an oxidant. The reaction condition is simple, the reaction temperature is 40-60 DEG C, no noble metal catalyst is used in the scheme disclosed in the application, no heavy metal residue is caused, the raw materials used are commercial products, the oxidant and the catalyst are relatively inexpensive and easy-to-obtain substances, the reaction operation is simple, and the reaction product is easy to purify and the post-treatment is convenient.

The invention provides a preparation method and application of a sodium alginate film, and the method comprises the following steps: dissolving sodium alginate in deionized water, adding catalysts EDC and DMAP, dropwise adding a glutaric anhydride solution at 40-50 DEG C, reacting for 1 hour, and carrying out alcohol precipitation, washing and drying to obtain glutaric anhydride esterified sodium alginate; and preparing the glutaric anhydride esterified sodium alginate into a 2% w / v solution, adding 0.4% w / v glycerol as a plasticizer, stirring at 50 DEG C for 30 minutes, carrying out ultrasonic degassing, casting to form a film, drying at 35 DEG C, and balancing to obtain the sodium alginate film. According to the method, the sodium alginate film is directly endowed with an anti-ultraviolet function through esterification modification of glutaric anhydride, and meanwhile, the hydrophobicity and the water vapor barrier property of the film are improved, so that the film can be used for manufacturing a UVB protective film and the like.