546 results about "Hydroxylation" patented technology

The invention relates to the field of plastic bags, and discloses a biodegradable plastic bag and a preparation method thereof, the biodegradable plastic bag comprises polylactic acid, poly (butylene adipate-co-terephthalate), a functional additive, modified starch, a lubricant and an antioxidant; the functional additive is prepared by grafting hydroxylated modified castor oil and isocyanated montmorillonite loaded titanium dioxide; the hydroxylation modified castor oil is prepared by modifying castor oil with chloroethyl isocyanate, then reacting with N-allylimidazole, and then reacting with 6-mercaptohexyl-1-alcohol; the isocyanated montmorillonite loaded titanium dioxide is prepared by reacting montmorillonite loaded titanium dioxide obtained by a sol-gel method with isophorone diisocyanate; the modified starch is prepared by reacting octadecanoyl chloride and acryloyl chloride with starch, then carrying out graft copolymerization with ethyl acrylate and further introducing glycidyl methacrylate, so that the plastic bag is endowed with excellent mechanical properties, biodegradability and antibacterial property.

The invention relates to the technical field of degradable PE (polyethylene) packaging materials, and discloses a PE film, a preparation process and application in tissue packaging, and the PE film is prepared by the following steps: by taking 7-(diethylamino) coumarin-3-carboxylic acid, 2-naphthyl methanol and epoxy chloropropane as raw materials, carrying out esterification reaction and quaternization reaction to prepare an epoxidized biodegradable organic photosensitizer; based on an epoxy-hydroxyl ring-opening reaction mechanism, hydroxylated titanium dioxide nanoparticles and polyvinyl alcohol resin are respectively modified by using an epoxidized biodegradable organic photosensitizer, and compounding is performed based on a pi-pi accumulation effect between aromatic rings to prepare the ultraviolet light dependent photo-biodegradable component. According to the present invention, the ultraviolet light dependent light-biological degradation component, the compatible component and the composite auxiliary agent are added to the polyethylene matrix, and blow molding is performed to obtain the PE film, and the film product shows excellent light-biological dual degradation performance, has actual use value, and can be used in the tissue packaging field.

The invention discloses preparation and application of a manganese hydroxylate modified zirconium-based metal organic framework, and belongs to the technical field of wastewater treatment. According to the preparation method, firstly, Mn oxide serves as a dopant, naphthalic acid serves as a frame connector, a zirconium-manganese bimetal organic frame is prepared through a hydrothermal method, and hydroxylation treatment is conducted through an alkali solution; mn replaces Zr atoms on a zirconium cluster to form high charge density with Zr, Mn and Zr can jointly participate in an electron transfer process and an active oxygen generation process to form double active centers, and the catalytic activity of a Fenton-like system is enhanced, so that the oxidative adsorption removal rate of As is remarkably improved. Experimental results show that the As removal rate can still reach 95.1% after five cycles, the targets of oxidative adsorption of As and reutilization are achieved, and the application of the zirconium-based metal organic framework in the field of catalytic adsorption of As is expanded.

The invention discloses a method for preparing a micro-particle-size negative oxygen ion purifying agent from a nano material, and relates to the technical field of air purifying agents, the method comprises the following preparation steps: step 1, pouring 5-6.5 g of modified tourmaline powder and 10 g of an amino acid-nano particle compound into 200 mL of deionized water, then adding 0.5-0.54 g of polyvinylpyrrolidone, carrying out ultrasonic treatment for 30-40 min, then adding 0.5-0.54 g of polyvinylpyrrolidone into the deionized water, carrying out ultrasonic treatment for 30-40 min, and carrying out ultrasonic treatment for 30-40 min; carrying out ball milling until the particle size is 1-5 microns; 2, adding 2-2.6 g of a chitosan solution with the concentration of 1% after ball milling, adjusting the pH value of the system to 6, and stirring at 50 DEG C for 1 h; according to the method for preparing the micro-particle-size negative oxygen ion purifying agent from the nano material, tourmaline powder is modified, so that the surface hydroxylation degree of the tourmaline powder is improved, lattice defects are increased, the negative oxygen ion release efficiency is remarkably improved, meanwhile, the tourmaline powder is compounded with white carbon black, interface charge conduction can be enhanced, and continuous release of negative oxygen ions is further promoted.

The invention relates to a three-dimensional boron nitride skeleton, a high-thermal-conductivity insulating composite material and a preparation method and application thereof, and belongs to the technical field of composites.The preparation method of the three-dimensional boron nitride skeleton comprises the steps that S1, hydroxylation treatment is conducted on boron nitride, and hydroxylated boron nitride is obtained; s2, carrying out surface modification on the hydroxylated boron nitride by adopting a silane coupling agent to obtain modified boron nitride; s3, uniformly mixing the modified boron nitride with saccharides, and performing compression molding to obtain a prefabricated blank; and S4, putting the prefabricated blank in water, and dissolving to remove saccharides, thereby obtaining the three-dimensional boron nitride skeleton. The preparation method of the three-dimensional boron nitride skeleton provided by the invention is simple in process, environment-friendly and low in cost, and the prepared three-dimensional boron nitride skeleton has relatively good structural strength and stability.

The invention discloses an ultrasonic activation type piezoelectric gel dressing and a preparation method and application thereof.The surface of a system is an antibacterial hydrogel layer, the antibacterial hydrogel layer is composed of polyethyleneimine (PEI) and polyvinyl alcohol (PVA) cross-linked hydrogel, and ultrasound and current can be transmitted to a deep area; bT-dNO piezoelectric nanoparticles are packaged inside, and BT-dNO is prepared by coating a nitric oxide (NO) donor on the surface of piezoelectric barium titanate (BT) subjected to hydroxylation and dopamine modification. Under the stimulation of low intensity focused ultrasound (LIFU), the donor can release NO as required, and the BT nanoparticles can generate reactive oxygen species (ROS) and output piezoelectric current. The dressing system has an effective combined repair effect, excellent biocompatibility and good anti-inflammatory ability.

The invention belongs to the technical field of triple negative breast cancer, and particularly relates to application of a polypeptide capable of specifically blocking phosphorylation of metabolic enzyme PSAT1S337 and functional remodeling of PSAT1 in preparation of a triple negative breast cancer treatment product. The phosphorylated polypeptide targeting PSAT1S337 is designed, and it is found that the polypeptide obviously inhibits growth of triple negative breast cancer tumors and can improve the curative effect of anti-PD-1 immunotherapy at the animal level. Meanwhile, the invention further provides application of the reagent for detecting the phosphorylation level of the PSAT1S337 and / or the hydroxylation level of the GPX4P159 in preparation of products for diagnosing and prognosing the triple negative breast cancer. The invention discloses a molecular mechanism of functional remodeling of the serine metabolic enzyme PSAT1 in occurrence and development of cell ferroptosis and triple negative breast cancer, and provides a new thought and an effective scheme for research and development of anti-tumor drugs for targeted serine metabolism reprogramming and early diagnosis of tumors.

The invention relates to the technical field of adhesives, and provides a high-thermal-conductivity modified silane polyether adhesive and a preparation method thereof.The silane-terminated polyether sealant is prepared from silane modified polyether resin, modified filler, a flame retardant, a silane coupling agent, a catalyst, an antioxidant and a water removal agent; the modified filler is obtained by grafting a hydroxylated AlN filler or a hydroxylated BN filler or a hydroxylated AlN and hydroxylated BN compound filler with silane under the catalysis of a weak acid to form a Si-O-Al or / and Si-O-B covalent bond network, and then mixing the Si-O-Al or / and Si-O-B covalent bond network with nano silicon dioxide particles of which the surfaces are coated with polydopamine. Through a multi-dimensional filler modification technology and reasonable matching of other auxiliaries, the problem of synergism of heat conduction, flame retardance and mechanical properties of the MS adhesive under a high filling system is solved, and the material is suitable for a new energy power battery module.

The invention relates to a bacteriostatic washing machine tank cleaning block composition and a preparation method thereof, and the bacteriostatic washing machine tank cleaning block composition comprises the following components: peroxide salt, a surfactant, a chelating agent, an acid substance, modified silicon dioxide, an active oxygen activator, a release agent, an adhesive, a filler and water; wherein the modified silicon dioxide is obtained by firstly hydroxylating silicon dioxide, then carrying out esterification reaction with hexadecenoic acid and linolenic acid, and finally polymerizing with sodium acrylate. The modified silicon dioxide can generate mechanical friction with stubborn dirt to promote the dirt to fall off, a high-crosslinking-degree net-shaped organic chain segment formed on the surface of the modified silicon dioxide has amphipathicity, after the modified silicon dioxide is compounded with the surfactant and other components, a synergistic effect is generated to improve the decontamination effect, the compatibility of all the components can be improved, and the cleaning effect is improved. Falling stubborn dirt can be wrapped, and the decontamination effect is further improved; all the components are compounded, so that a good antibacterial effect and the like are achieved, and a good prospect is achieved.

In some aspects, the present disclosure pertains to systems for forming hydrogels that comprise (a) a radiopaque polyamino compound and (b) a reactive polymer comprising a plurality of hydrophilic polymer segments and a plurality of reactive moieties, wherein the reactive moieties are reactive with amino groups of the radiopaque polyamino compound, and wherein the radiopaque polyamino compound is produced by a method that comprises: (i) converting hydroxyl groups of a polyhydroxylated radiopaque compound to amino groups, (ii) converting vicinal diol groups (—CHOHCH2OH groups) of a polyhydroxylated radiopaque compound into hydroxyaminoethyl groups (—CHOHCH2NH2 groups), or (iii) converting vicinal diol groups of a polyhydroxylated radiopaque compound into aminomethyl groups (—CH2NH2 groups). In other aspects, the present disclosure pertains to hydrogels formed from such systems and to methods of treatment using such systems.

The invention provides a catalyst for synthesizing N-methylaniline and a preparation method thereof, the catalyst comprises an active component, a carrier and an auxiliary agent, the active component comprises oxygen-containing compounds of copper, zinc and chromium, the carrier is gamma-alumina subjected to surface hydroxylation treatment, and the auxiliary agent is a cerium-molybdenum bimetallic alloy. The preparation method comprises the following steps: loading the active component on the hydroxylation carrier through ultrasonic impregnation, drying, further loading the cerium-molybdenum auxiliary agent, and carrying out reduction alloying and roasting activation to form the composite catalyst. The catalyst is a regular cylinder, has the diameter of 4-6mm and the length of 4-6mm, has an optimized pore structure and surface properties, and is suitable for methylation reaction of aniline and methanol. According to the method, the dispersity of active components is improved through modified chromic oxide, the mass transfer efficiency is enhanced through a hydroxylation carrier, the synergistic catalysis effect of cerium-molybdenum alloy is combined, the reaction activity and selectivity are remarkably improved, meanwhile, side reactions are inhibited, the stability is enhanced, and the method can be widely applied to industrial production of N-methylaniline.

The application discloses an improved electrolytic synthesis method of 3,6-dichloropicolinic acid, which comprises the following steps: adopting a diaphragm electrolytic cell, taking an aqueous solution containing 3,4,5,6-tetrachloropicolinic acid and a certain flow of CO2 gas as a cathode liquid, taking an aqueous solution of alkali metal hydroxide as an anode liquid, taking silver as a cathode, and taking a nickel-based material as an anode to carry out an electrolytic reaction, and obtaining 3,6-dichloropicolinic acid after the electrolytic reaction is completed. In the electrolytic process, the anode is separated from the cathode, so that corrosion is avoided; meanwhile, the CO2 gas is introduced to effectively control the occurrence of a hydroxylation side reaction, the molar yield of a hydroxyl byproduct is reduced from 20% to 35% to 2% to 8%, the molar yield of 3,6-dichloropicolinic acid is increased from 45% to 50% to above 80%, and the highest can reach 92.2%.

The invention discloses application of a reducing agent in heme peroxidase catalytic reaction, the reducing agent is selected from ascorbic acid, dehydroascorbic acid, gallic acid and pyrogallic acid, and the reducing agent has a remarkable promotion effect on oxidation reaction and hydroxylation reaction catalyzed by heme peroxidase. A new scheme is provided for improving the catalytic oxidation efficiency of the heme peroxidase, and the development and application potential is huge.

The invention discloses a preparation method of 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine as an elinnetin intermediate, and belongs to the technical field of medicine synthesis. According to the invention, cheap and easily available 3-nitro-4-hydroxypyridine is used as an initial raw material, and the 2-chloro-4-(4-fluoro-2-methylphenyl)-5-aminopyridine is synthesized at low cost and high yield through the steps of halogenation, coupling, hydroxylation, reduction, condensation and the like. The raw materials used in the whole process are simple and easy to obtain, the reaction conditions are milder, and the reaction route is short. According to the invention, the Suzuki coupling reaction is firstly carried out, and then the hydroxylation of the pyridine 2 position is carried out, so that the use of an anhydrous reagent and harsh anhydrous reaction conditions are effectively avoided, and the reaction cost is remarkably reduced. In addition, the method is easy and convenient to operate, good in stability, high in total yield and suitable for industrial large-scale production.

The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.

The invention discloses a composite material modified electrode based on a functionalized single-walled carbon nanotube and application thereof, and belongs to the technical field of electrochemistry, the modified electrode comprises a glassy carbon electrode and a functionalized single-walled carbon nanotube-glucose composite material coating coated on the surface of the glassy carbon electrode; the mass ratio of functionalized single-walled carbon nanotubes to glucose in the coating is (0.2-5): 1, and the functionalized single-walled carbon nanotubes comprise at least one of hydroxylated single-walled carbon nanotubes, carboxylated single-walled carbon nanotubes and aminated single-walled carbon nanotubes, preferably hydroxylated single-walled carbon nanotubes. The composite material modified electrode provided by the invention has a large number of active sites, and by effectively utilizing the synergistic effect of the hydroxylated single-walled carbon nanotubes and glucose, the modified electrode shows excellent selective recognition capability on amino acid enantiomers and also shows good stability; and the method has a good application prospect in quantitative analysis of the amino acid enantiomers.

The invention discloses a silver nanowire and polymer composite transparent conductive film and a preparation method thereof, and belongs to the field of conductive films. According to the preparation method disclosed by the invention, hydroxylation treatment is performed on the surface of AgNWs through ultraviolet irradiation induction to generate a large number of-OH groups, and the-OH groups and sulfonic acid groups (-SO3H) in PEDOT: PSS form chemical bonding, so that the contact resistance between the AgNWs and the PEDOT: PSS is remarkably reduced, and a continuous and efficient conductive network is constructed. Meanwhile, the tight coating structure of hydroxylated AgNWs and PEDOT: PSS effectively inhibits oxidation and ion migration of the silver nanowires in a humid and hot environment, and the stability of the transparent conductive film is remarkably improved.

The invention discloses a phosphorus-nitrogen synergistic flame-retardant phenolic aldehyde curing agent as shown in a formula (I) and a preparation method thereof, and the preparation method of the compound comprises the following steps: under the condition of nitrogen, by taking water as a solvent, adding a basic catalyst, uniformly stirring, adding melamine and an aldehyde compound to carry out hydroxylation reaction, then adding a phosphorus-containing monomer to carry out dehydration condensation reaction, and obtaining the phosphorus-nitrogen synergistic flame-retardant phenolic aldehyde curing agent. And neutralizing the reacted material, adding a phenolic compound, heating for reaction, and then carrying out post-treatment to obtain the product. Furthermore, the resin composition for the copper-clad plate is formed by mixing the multifunctional epoxy resin, the phosphorus-nitrogen synergistic flame-retardant phenolic curing agent, the benzoxazine resin, the active ester curing agent, the accelerant, the filler and the solvent, and the prepared phosphorus-nitrogen synergistic flame-retardant copper-clad plate has excellent moisture absorption performance, dielectric property, heat resistance, flame retardance, toughness and the like; the method is suitable for the field of high-performance printed circuit boards. # imgabs0 #

The invention discloses a method and a device for degrading bisphenol A by using a propane matrix membrane bio-membrane reactor, and belongs to the technical field of microorganism application. The method specifically comprises the following steps: inoculating activated sludge into a membrane bio-membrane reactor with a basic inorganic salt culture medium, and introducing propane to promote the growth of a bio-membrane on hollow fiber membrane filaments in the membrane bio-membrane reactor, so as to obtain the membrane bio-membrane reactor after membrane formation is completed; the method comprises the following steps: introducing bisphenol A-containing wastewater to be treated into a membrane bio-membrane reactor, continuously introducing propane, and inducing microorganisms to express alkane monooxygenase and cytochrome P450 monooxygenase, thereby promoting hydroxylation of bisphenol A and degrading bisphenol A into a downstream product of which the toxicity is lower than that of bisphenol A. The propane is used as a carbon source and an electron donor, the propane can be efficiently utilized to provide a safe and good environment for biodegradation of bisphenol A, and secondary pollution possibly caused by a traditional carbon source is avoided.

The invention provides a preparation method and application of a modified PVC adsorbent for gold extraction of carbonaceous gold ore, and belongs to the technical field of organic polymer materials and resource utilization. Based on construction of a hydroxylation-xanthate esterification reaction and bifunctional adsorption sites, a series of chemical modification paths of acetate nucleophilic substitution-hydrolysis-carbon disulfide alkali treatment are established, and xanthate functional groups with high reaction activity are accurately constructed on an inert PVC framework. Sulfur atoms in xanthate groups of the modified PVC are excellent electron donors and can generate strong chemical adsorption with metal impurities or polar sites on the surface of carbon, meanwhile, Van der Waals interaction between a main chain of the modified PVC and the carbon is reserved, and unmodified PVC or single hydroxylated PVC does not have the synergism of chemical adsorption and physical adsorption, so that the modified PVC can be used for preparing the carbon-modified PVC composite material, and the carbon-modified PVC composite material can be used for preparing the carbon-modified PVC composite material. And leap-type improvement of the adsorption capacity and selectivity of organic carbonaceous in minerals is realized.

The utility model provides an energy-saving device for separating and purifying materials after hydroxylation reaction of phenol and hydrogen peroxide, and relates to the technical field of chemical synthesis. Materials obtained after phenol hydrogen peroxide hydroxylation reaction are separated and purified through the extraction tower, the extraction agent recovery tower, the first phenol removal tower, the tar removal tower, the second phenol removal tower, the catechol removal tower, the light component removal tower and the hydroquinone tower, the whole technological process is simple, the yield is high, and the high-purity hydroquinone product and the high-purity catechol product can be obtained; according to the utility model, the extraction tower is adopted to replace a dehydration rectifying tower in the traditional process to remove phenol-containing wastewater, so that the phenol recovery rate is improved, and the subsequent wastewater treatment burden is reduced; and the tar removal tower is arranged behind the phenol removal tower I, so that the retention time of tar impurities in the whole process system is shortened, and the process safety is improved. According to the utility model, the high-temperature waste heat at the top of the dephenolization tower I is recovered by combining waste heat recovery with a mechanical steam recompression energy-saving technology, so that the process energy consumption of the operation of the whole device is effectively reduced.

A near-atomic-scale electrolytic machining method based on an interface self-assembly biomask comprises the steps that firstly, hydroxylation pretreatment is conducted on the surface of an anode of a workpiece, then the surface of the anode is covered with an organic solvent phase containing phospholipid monomers, water-phase electrolyte drops are introduced, molecular self-assembly driving force at an oil-water-metal three-phase interface is utilized, and the surface of the anode of the workpiece is subjected to near-atomic-scale electrochemical machining. And rapidly forming a layer of ultrathin, continuous and stable support phospholipid bilayer mask on the surface of the workpiece in situ. Then, biological nanochannels are embedded in the biomimetic mask to construct a confinement ion transport path. And finally, a precise pulse electric field is applied, electrolyte ions are driven to be strictly limited in the nanometer channel and transmitted to the surface of the workpiece, local anodic dissolution is triggered, and therefore localized material removal of the nanometer scale or even the near-atomic scale is achieved. According to the method, the technical bottleneck that the high-quality phospholipid bilayer is difficult to prepare on the high-surface-energy metal surface is solved, and a new way is provided for ultra-precision electrolytic machining.

The application discloses a kind of generation (4S) 4-hydroxyisophorone monooxygenase mutant and preparation method thereof, the monooxygenase is cytochrome P450 BM3 Monooxygenase from bacillus megaterium. The cytochrome P450 BM3 Monooxygenase mutant has high stereoselectivity and high reaction activity to catalyze isophorone hydroxylation, mutant R47L / Y51F / F81W / A191T / N239H / I259V / A276T / A328I / A330S / L353I / I401L / L437LL catalyzes isophorone to obtain (4S) 4-hydroxyisophorone diastereomeric excess rate can reach 95%, yield can reach 96%; the cytochrome P450 BM3 Monooxygenase mutant catalyzes isophorone synthesis (4S) 4-hydroxyisophorone process is simple, environmental protection, and industrialization prospect is good.

The invention discloses 10-hydroxydecanoic acid as well as a preparation method and application thereof, and belongs to the technical field of cosmetics, Candida lipolytica is taken as a fermentation thallus, the Candida lipolytica contains alkane monooxygenase (CYP450), alcohol dehydrogenase (ADH), fatty alcohol oxidase (FAO) and fatty aldehyde dehydrogenase (FALDH), amplification and activation are performed on the Candida lipolytica in a seed culture medium, and the Candida lipolytica is obtained. The method comprises the following steps: inoculating a seed solution into a liquid culture medium, enabling a strain to adapt to a culture environment in advance, reducing strain death caused by environmental mutation after inoculation, inoculating the seed solution into the liquid culture medium, culturing until OD600 is 45-55, realizing high-density enrichment of the strain, being beneficial to increasing the content of CYP450, ADH, FAO and FALDH, adding decane and Tween 80, and enabling the Tween 80 to be capable of increasing the permeability of a cell membrane and increasing the reaction rate, the CYP450 is used for catalyzing decane to carry out hydroxylation, and ADH, FAO and FALDH are used for carrying out oxidation, so that the high-purity 10-hydroxydecanoic acid is obtained.

The invention provides a method for improving fermentation yield and sugar-acid conversion rate of 5-hydroxytryptophan, alpha-ketoglutaric acid ferrous salt, alpha-ketoglutaric acid zinc salt, alpha-ketoglutaric acid cobalt salt and alpha-ketoglutaric acid manganese salt are added into a fermentation culture medium according to a specific proportion, alpha-ketoglutaric acid directly participates in TCA circulation, circulation operation can be accelerated, generation of NADH and FADH2 is increased, the yield of 5-hydroxytryptophan is increased, and the yield of 5-hydroxytryptophan is increased. The ATP synthesis efficiency is improved, and more energy is provided for cell growth; the alpha-ketoglutaric acid can balance amino acids required in the growth process of escherichia coli, promote the generation of proteins and nucleic acids and accelerate the growth of thalli; the alpha-ketoglutaric acid metal salt can improve the utilization efficiency of microelements by thalli; ferrous ions are cofactors of 5-hydroxytryptophan hydroxylase and can accelerate the hydroxylation process of tryptophan. Through the synergistic effect of the added components, the yield of the 5-hydroxytryptophan and the sugar-acid conversion rate are improved.

The present invention relates to a cytochrome P450 monooxygenase mutant and its application in hydroxylation of methylpyrazine compounds, belonging to the technical field of enzyme engineering. The amino acid sequence of the cytochrome P450 monooxygenase mutant provided by the present invention is shown in SEQ ID NO.2. The cytochrome P450 monooxygenase mutant L76S / A83E provided by the present invention exhibits hydroxylation activity towards methylpyrazine substrates, and the reaction conversion rate is greater than or equal to 95%, achieving a breakthrough in the catalytic activity of cytochrome P450 monooxygenase from non-existent to existent. Therefore, the cytochrome P450 monooxygenase and its gene described in the present invention have good prospects for industrial application development.

The present invention relates to a cosmetic composition comprising 2,4-diaminopyrimidine-3-N-oxide and / or one of its organic or mineral acid salts and / or one of its hydrates, piroctone olamine, niacinamide, and at least 1% by weight of a particular hydroxylated compound. The invention also relates to a cosmetic treatment method for human keratinous materials such as skin, particularly scalp, hair, and / or eyelashes, comprising at least the application of the cosmetic composition according to the present invention. The present invention further relates to the use of said cosmetic composition to treat hair loss and / or promote the regrowth of keratin fibers.

The application belongs to the field of compound synthesis and particularly relates to a photocatalytic preparation method of quinoxaline-2,3-dione compounds, which comprises the following steps: preparing a raw material solution containing quinoxaline-2-ketone, mercaptan, a photocatalyst and acetonitrile, and performing a photocatalytic reaction under light to obtain a quinoxaline-2,3-dione compound product; the mercaptan is C1-C4 alkyl mercaptan, and the -SH is connected to a primary carbon or a secondary carbon. The application adopts a photocatalytic method to perform hydroxylation on the C3 position of quinoxaline-2-ketone, and further controls the combination of the mercaptan and acetonitrile solvent to improve the photocatalytic reaction effect of C3 hydroxylation.

The present application relates to a kind of cytochrome P450 oxidase CYP716C52 protein, and the CYP716C52 protein coding gene, the protein can catalyze hydroxylation of maytenic acid C2 position to generate triptolide acid C, in turn participate in triptolide biosynthesis.

We are disclosing derivatives of 5-hydroxylated polymethoxyflavones. The derivatives offer enhanced oral bioavailability and improved intestinal permeability. The derivatives of the invention release the biologically active 5-hydroxylated polymethoxyflavones that are activated by chemical or enzymatic processes in the GI Tract. The derivatives are constructed as bioreversible prodrugs containing the bioactive molecules covalently linked with lipids like fatty acids, glycerides or phospholipids. The derivatives are useful against inflammatory conditions and aging. Formulations including the derivatives are also disclosed.