43 results about "Tissue penetration" patented technology

The invention provides an activatable head and neck cancer diagnosis and treatment integrated nanoprobe and a preparation method and application thereof.The preparation method includes the steps that according to an original data matrix, an adaptive spectrum correction algorithm is applied to eliminate background noise of an instrument, and when the relative fluctuation of spectral intensity exceeds a preset threshold value by 5%, a sliding window filtering technology is adopted, the window size is 5 nanometers, and the spectrum intensity is obtained; generating a de-noised spectral data set; measuring the pH value of the head and neck cancer tissue microenvironment by using a pH value sensor, recording the emission peak position change of the near-infrared quantum dots when the pH value is less than 6.5 in combination with the de-noising spectral data set, analyzing the frequency band displacement by adopting a Gaussian fitting algorithm, and generating a mapping data set of the pH value and the frequency band displacement; and aiming at the activation spectrum fingerprint data set, applying a dynamic spectrum matching algorithm, comparing with the spectrum response characteristic data set, calculating a cosine similarity coefficient, and when the similarity exceeds 0.85, determining the activation state and the tissue penetration depth of the nanoprobe, and generating a diagnosis and treatment parameter adjustment instruction set.

This invention discloses a lipid assembly loaded with 5-aminolevulinic acid and its preparation method. The lipid assembly is a hollow sphere with a core consisting of a hydrophilic phospholipid-chelating agent conjugate formed by chelation with a reactive phospholipid PEG reagent. The outer layer of the phospholipid-chelating agent conjugate is loaded with 5-aminolevulinic acid via hydrazone bonds, and then combined with a radionuclide as an internal light source excitation photosensitizer. The lipid assembly is loaded with 5-ALA via hydrazone bonds. Utilizing the acid-sensitive bond-breaking characteristics of hydrazone bonds and the prodrug properties of 5-ALA, combined with a radionuclide labeled on the surface of the lipid assembly as an internal light source excitation photosensitizer, this invention can overcome the limitations of external light penetration depth in traditional photodynamic therapy, achieving deep PDT treatment. Combined with chemotherapy drugs, it can minimize the toxic side effects on normal tissues during the combined use of radionuclides and photosensitizers in targeted therapy.

The invention belongs to the technical field of nano biological materials, and particularly relates to a near-infrared two-region excitation and emission lanthanide nano fluorescent probe as well as a preparation method and application thereof. Lanthanide ions with near-infrared two-region absorption characteristics are used as sensitizers, nanocrystalline with a co-doped structure formed by the lanthanide ions and activator ions is used as a core, and a pure-phase matrix material shell layer which is the same as a core lattice is grown on the surface of a core particle in situ. The nano fluorescent probe can generate tunable near-infrared two-region fluorescence emission with the wavelength of 1000 to 3000 nm under the excitation of near-infrared light with the wavelength of more than 1000 nm. The near-infrared two-region excitation and emission characteristics of the nano fluorescent probe can provide higher tissue penetration depth and signal-to-noise ratio for in-vivo imaging. The nano fluorescent probe shows excellent performance in living body angiography, dynamic observation of intestinal tracts and multi-channel near-infrared two-region imaging, and has wide application prospects in the fields of biomedical detection, early diagnosis of diseases, surgical navigation and the like.

The invention provides a near-infrared beta-galactosidase fluorescent probe as well as preparation and application thereof, and relates to the technical field of fluorescent probes, according to the near-infrared beta-galactosidase fluorescent probe, when beta-galactosidase exists, a D-galactosyl group can be split, meanwhile, self-elimination of p-hydroxybenzyl is removed, a fluorescent signal unit is released, and the beta-galactosidase can be detected by the near-infrared beta-galactosidase fluorescent probe. The fluorescence signal is obviously enhanced. Excitation and emission spectra of the near-infrared beta-galactosidase fluorescent probe are both in a near-infrared region, the fluorescence intensity at 760 nm is rapidly increased, the fluorescence intensity rapidly reaches a stable state after 30 min, and compared with a visible light probe, the near-infrared beta-galactosidase fluorescent probe has deeper tissue penetrating capacity, background interference can be effectively avoided, and the resolution ratio is improved; the compound can be applied to beta-galactosidase detection imaging and preparation of beta-galactosidase detection imaging reagents, especially breast cancer detection reagents.

The invention relates to the technical field of biological medicine, in particular to a TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof, and discloses a fluorescent molecular probe named as' TREM-1 targeted fluorescent molecular probe as well as a preparation method and application thereof '. The invention aims to solve the problems of large molecular weight, poor pharmacokinetic performance, limited tissue penetration, high imaging background and poor imaging timeliness of the existing antibody fluorescent probe. The probe comprises a TREM-1 targeting module (TDM), a near-infrared fluorescence reporter group, a dark quenching group and a conformational sensitive connecting arm (CSL). The fluorescence of the probe is quenched before the probe is combined with TREM-1, and after the probe is combined with a target spot, TDM specific binding induces CSL conformation rearrangement, so that a reporter group and a quenching group are spatially separated, fluorescence resonance energy transfer (FRET) is relieved, and fluorescence activation is realized. According to the invention, rapid, high-contrast and low-background fluorescence imaging of atherosclerotic plaques is realized, and the probe is small in molecular size, strong in tissue penetrability and rapid in-vivo clearing.

The invention discloses a preparation method and application of near-infrared carbon dots capable of efficiently generating active oxygen and having targeting capacity, and belongs to the technical field of carbon nanomaterials. Compared with conventional blue-green light carbon dots, the near-infrared carbon dot provided by the invention has the advantages of large tissue penetration depth, small self-luminous interference of organisms, small damage to tissues and the like. The carbon dots provided by the invention can efficiently generate singlet oxygen, and have the capability of photodynamically killing tumor cells. Besides, abundant functional groups on the surfaces of the carbon dots are utilized, molecules capable of targeting organelles are modified on the surfaces of the carbon dots, so that the carbon dots can accurately position and target mitochondria, and compared with carbon dots without targeting capability, the carbon dots have stronger killing power on cancer cells.

The invention discloses a near-infrared photosensitizer for specifically recognizing fibroblast activation protease (FAP-alpha) as well as a preparation method and application of the near-infrared photosensitizer. A cyanine derivative is used as a fluorescent parent nucleus (ICyOH) of the photosensitizer, the fluorescence of the photosensitizer can be almost completely masked by modifying the photosensitizer, and after the photosensitizer reacts with FAP-alpha for 60 minutes, the fluorescence intensity is rapidly enhanced, so that high sensitivity, good selectivity and anti-interference performance are shown. The ZGP-LL-ICy is a photosensitizer with a cyanine structure, FAP-alpha fluorescence enhancement and high selectivity to FAP-alpha, the reagent shows high selective response to FAP-alpha enzyme, active ICyOH molecules with near-infrared fluorescence are released under the action of enzymolysis, and tumor fluorescence imaging of deep tissue penetration is achieved. Meanwhile, the activated ICyOH can generate cytotoxic active oxygen under the illumination condition, and photodynamic therapy on pancreatic cancer is achieved. The reagent has the advantages of low background fluorescence, deep tissue penetration, diagnosis and treatment integration and the like, and has important application value in the fields of early diagnosis and precise treatment of pancreatic cancer.

The invention relates to a nitroimidazole group meso-substituted heptamethine cyanine dye as well as a preparation method and application thereof. According to the dye, a nitroimidazole group is introduced into the middle position of a heptamethine cyanine parent nucleus, so that the dye has excellent absorption characteristics in a near-infrared region, the excitation wavelength is 730-780 nm, the emission wavelength is 800-860 nm, and the dye has good tissue penetrating power. The nitroimidazole group can effectively quench fluorescence in an excited state through a light-induced electron transfer effect, energy is promoted to be released in a non-radiative transition mode, the photothermal conversion efficiency is remarkably improved, and meanwhile high light stability and low fluorescence quantum yield are kept. The dye can be further prepared into a nano preparation and shows excellent biocompatibility and tumor targeting ability. The compound has wide application prospects in the fields of non-diagnostic or therapeutic protein labeling, bioimaging, photothermal therapy and the like, is especially suitable for preparing efficient photosensitive reagent drugs for tumor photothermal therapy, and provides a new strategy for design of near-infrared photothermal diagnosis and treatment materials.

This invention discloses a fluorescence-enhancing nanoparticle, its preparation method, and its applications, relating to the fields of organic fluorescent molecules and bioimaging technology. The nanoparticle comprises: NIR-II fluorescent molecules and an amphiphilic polymer encapsulating the NIR-II fluorescent molecules; the amphiphilic polymer has a hydrophilic segment and a rigid hydrophobic segment. The nanoparticle of this invention, based on "carrier microenvironment engineering," utilizes the rigid confinement and interfacial isolation provided by the amphiphilic polymer with the rigid hydrophobic segment for dual brightening, serving as a universal brightening platform applicable to various NIR-II fluorescent molecules. This nanoparticle can significantly improve aqueous phase quantum yield, enhance contrast and resolution in in vivo vascular imaging, improve deep tissue penetration, increase imaging sensitivity, and facilitate detection under low signal conditions. It also exhibits good stability and biocompatibility, supporting lesion imaging and intraoperative navigation applications.

The invention relates to the field of aggregation-induced emission photosensitizers, in particular to a mitochondria-targeted aggregation-induced emission photosensitizer as well as a preparation method and application thereof. The aggregation-induced emission photosensitizer disclosed by the invention is simple in synthetic route, is emitted in a near-infrared region, has deeper tissue penetration depth and excellent photodynamic activity, realizes specific killing of tumor cells through precise targeting mitochondria, triggers pyroptosis of cells and regulates and controls whole-body anti-tumor immune response.

The invention discloses an orange fluorescent silicon nanodot, a preparation method thereof and an application of the orange fluorescent silicon nanodot in mitochondrial imaging in living cells, the method comprises the following steps: S1, dissolving tetramethyl rhodamine methyl ester in ultrapure water, then adding N-(2-aminoethyl)-3-aminopropyltrimethoxysilane, uniformly stirring, and carrying out hydrothermal reaction on the obtained mixture; and S2, cooling after the reaction is finished, purifying the product by using a chromatographic column, eluting by using an eluent, collecting the eluent, and drying to obtain the orange fluorescent silicon nanodot. The silicon nanodot provided by the invention has the advantages of good light stability, high quantum yield and the like, and can be successfully applied to positioning imaging of mitochondria in living cells; compared with common blue-green fluorescence, orange fluorescence has better tissue penetrating ability and background interference resistance; the O-SiNDs prepared by the invention also has the property similar to that of lipophilic cations, and can realize high-specificity targeted marking on mitochondria of living cells.

The application discloses an anti-tumor nano self-assembled particle targeting mitochondria and a preparation method and application thereof. The nano self-assembled particle takes a photothermal agent as a core and takes an active oxygen donor reagent coated on the surface of the photothermal agent as a shell. The application utilizes the photothermal agent and the active oxygen donor to prepare the nano particle through self-assembly, realizes photodynamic therapy excited by near-infrared laser, has a deeper tissue penetration depth and causes less damage to normal tissues; the active oxygen is produced by breaking a peroxide bridge in artemether, and the limitation of traditional photodynamic therapy on anoxic conditions in a tumor microenvironment is overcome; the active oxygen is produced on a subcellular level by targeting mitochondria of tumor cells; and the nano particle has self-reporting fluorescence and can realize real-time monitoring of the in-vivo distribution of the nano particle.

An ablation instrument comprises a cable, a conductive antenna body coupled to the cable and configured to deliver ablative energy to tissue, and a tip having a cross-sectional diameter of less than 5 mm. The tip comprises a blade configured to cut a slit in the tissue. The blade comprises a plurality of cutting edges, and each cutting edge of the plurality of cutting edges has a width between 30% and 50% of the cross-sectional diameter of the tip.

The invention relates to a near-infrared band ratio type rare earth fluorescent nanoprobe as well as a preparation method and application thereof. The ratio-type rare earth fluorescent probe is a nanocrystal with a core-shell structure, an inner core layer of the ratio-type rare earth fluorescent probe is a light-emitting layer which absorbs laser radiation and emits a near-infrared fluorescent wave band, a middle shell layer of the ratio-type rare earth fluorescent probe is a light-emitting shell layer which absorbs laser radiation and emits another near-infrared fluorescent wave band, and an outer shell layer of the ratio-type rare earth fluorescent probe is an inert shell layer. Wherein the inner core layer takes Tm < 3 + > as a light-emitting center, and the light-emitting shell layer takes Er < 3 + > as a light-emitting center. Through difference response of two fluorescence signal wave bands to water absorption, an index relation between ratio-type fluorescence signal intensity and tissue penetration depth is established, and noninvasive depth positioning and imaging of a mouse living body are realized. The fluorescent nanoprobe can be used for depth positioning of blood vessels of the brain, the abdomen and the legs of a mouse and continuous monitoring of a dynamic migration process from the blood vessels to bones, and has a wide application prospect in the aspect of in-vivo ratio depth imaging.

The application discloses a near-infrared organic room-temperature phosphorescent material based on benzothiadiazole and a preparation method and application thereof, and belongs to the technical field of organic luminescent materials. The near-infrared organic room-temperature phosphorescent material based on benzothiadiazole can effectively inhibit the quenching effect of water and oxygen on phosphorescence, has high-brightness long-life water-phase room-temperature phosphorescence, and can realize high-brightness organic room-temperature phosphorescence in water phase. The application further provides a preparation method of the near-infrared organic room-temperature phosphorescent material based on benzothiadiazole, and has the advantages of simple process and low cost. The near-infrared organic room-temperature phosphorescent material based on benzothiadiazole shows excellent tissue penetration ability in a living body, realizes high-signal-to-noise ratio phosphorescence imaging of various organs in practical application, and has a good application prospect in the field of biological imaging.

The application provides a near-infrared two-region fluorescent dye with mitochondrion targeting and aggregation-induced emission properties and application thereof in biological fluorescence imaging and tumor treatment. 41 H 37 F6N2PS, which has good light stability, outstanding mitochondrion targeting, clear ROS production mechanism and excellent photothermal performance. The substance has good mitochondrion targeting capacity and can destroy tumor mitochondria under laser irradiation of a certain intensity, thereby killing tumor cells. The aggregation-induced emission property makes it different from traditional aggregation quenching emission materials and has better biological imaging effect. The near-infrared property makes it have good tissue penetration capacity and biological fluorescence imaging effect. The substance has wide application prospects in near-infrared fluorescence imaging, preparation of mitochondrion targeting reagents and photodynamic therapy reagents. It can be applied to combined phototherapy of breast tumor PDT and PTT, and has simple synthesis steps and is conducive to commercial application and popularization.

The application discloses a kind of near-infrared fluorescent probe for detecting GSH and its preparation method and biological imaging application, belong to biological analysis technical field, the fluorescent probe NRh-BZ is by being decorated to oxygen heterocyclic skeleton with hemicyanine, increase conjugated structure, realize the detection of GSH in near-infrared light region, belong to off-on type fluorescent probe, with high selectivity, sensitivity and low cytotoxicity, its emission wavelength is 746nm, detection limit is as low as 46.8nM, can be applied to the detection imaging of GSH in living cell MCF-7 and rat liver tissue, and tissue penetration depth reaches 150 μm.The fluorescent probe NRh-BZ prepared in the application can quantitatively detect GSH in various biological systems.

The present invention provides a preparation method for a ruthenium-based covalent organic framework material, an antibacterial gel electrochemiluminescent device, and applications. The ruthenium-based covalent organic framework material, Ru@COFs, promotes the accumulation of tripropylamine co-reactants and accelerates the reaction rate with intermediates. The Ru@COFs emit stable, high-intensity near-infrared light near 630 nm, capable of deeper tissue penetration and reducing surface skin damage. The antibacterial gel electrochemiluminescent device utilizes a large-area light-emitting device combining flexible screen-printed electrodes with a double-network hydrogel. The nanoconfinement-enhanced near-infrared electrochemiluminescence of the Ru@COFs drives photodynamic therapy, achieving a deeper and safer antibacterial effect. The electrochemiluminescent device avoids the use of physical light sources, providing a model for the development of miniaturized, integrated wearable diagnostic and therapeutic devices.

The invention provides a composite glass cover plate and a preparation method and application thereof. The composite glass cover plate comprises a lower cover plate and a transparent glass substrate, the upper cover plate is arranged on the lower cover plate; the upper cover plate comprises a glass transparent area and an annular structural member embedded in the glass transparent area; the annular structural member penetrates through the upper and lower surfaces of the glass transparent area in the direction of the axis perpendicular to the surface of the glass transparent area; the annular structural member is blackened glass; the components of the glass transparent area, the annular structural member and the lower cover plate glass are the same; the glass transparent area, the annular structural part, the upper cover plate and the lower cover plate form an integral structure through vacuum hot pressing. The technical problem to be solved is how to prepare a composite glass cover plate, so that the composite glass cover plate can accurately control a light path transmitting and receiving angle and a total reflection critical angle, restrict light rays from entering skin in a fixed angle range, and improve the penetration depth of subcutaneous tissues. Meanwhile, compared with an ink product, the shading property is better, and the product strength is remarkably improved.

The invention discloses a near-infrared two-region AIE molecule with click activity for tumor treatment, and belongs to the technical field of aggregation-induced emission materials. The preparation method of the near-infrared two-zone AIE molecule with click activity comprises the following steps: dissolving a compound 1, a compound 2, tetrakis (triphenylphosphine) palladium and potassium carbonate in a mixed solution of tetrahydrofuran and water, and carrying out reflux reaction for 24 hours to obtain a compound 3; dissolving the compound 3 and the compound 4 in ethanol, and performing reflux reaction for 48 hours to obtain a compound 5; and dissolving the compound 5 and the compound 6 in dimethylformamide, and carrying out reflux reaction for 12 hours to obtain the near-infrared second-region AIE molecule. By constructing a strong donor-pi bridge-donor structure, a technical scheme of designing a near-infrared two-region AIE molecule with click activity is designed, a deeper tissue penetration depth can be realized, and meanwhile, the near-infrared two-region AIE molecule has excellent photodynamic activity, can play a good killing effect on cancer cells and does not influence normal cells.

The invention discloses an NIR-IIb response type up-conversion nanometer material, a hydrogen production nanometer reactor prepared from the NIR-IIb response type up-conversion nanometer material and application of the NIR-IIb response type up-conversion nanometer material, and belongs to the technical field of nanometer biomedical materials. The controllable hydrogen production nanoreactor is obtained by using a bionic carrier formed by lipidosome, a photosensitizer, a catalyst and a proton donor which are jointly wrapped in the bionic carrier, and an up-conversion nanomaterial prepared by a chemical synthesis method, a hydrothermal method and the like, and can generate hydrogen under the stimulation of light with specific wavelength. According to the nano-reactor provided by the invention, a proton donor is efficiently catalyzed to generate hydrogen, on-demand and controllable release of hydrogen at a focus part is realized by utilizing high-tissue-penetrability NIR-IIb stimulation, and the nano-reactor provided by the invention can effectively remove active oxygen at the focus part and relieve oxidative stress by controllably releasing the generated hydrogen, so that pulmonary fibrosis is effectively relieved. The nanoreactor provided by the invention has the advantages of good biocompatibility, high hydrogen production efficiency, strong targeting property, small treatment side effect and the like, and has a wide market application prospect.

The invention discloses a dye with up-conversion performance, and a synthesis method and application thereof. The dye generally has up-conversion performance, can emit fluorescent light (short wavelength) under irradiation of light (long wavelength) of 750-900 nm, and can avoid the problem of photobleaching caused by short wavelength excitation. Meanwhile, the dye has a high extinction coefficient and a high fluorescence quantum yield in an aqueous solvent and a polar protic solvent, so that the dye is very beneficial to fluorescence imaging, gene sequencing, biomacromolecule recognition and the like. Meanwhile, the upconversion mechanism also has deeper tissue penetrating ability, is beneficial to in-situ imaging and photodynamic therapy of deep pathological tissues of a living body, and has a very good application prospect.

A clofazimine-based pharmaceutical suspension and an application thereof, wherein a drug delivery system has near-infrared fluorescence, photoacoustic imaging effect and red dye characteristics for in vivo tracing, as well as a near-infrared photothermal effect for tumor treatment. The drug delivery system combines the near-infrared photothermal effect with the anti-tumor effect of the drug itself, and adopts a combination of phototherapy and traditional chemotherapy to achieve effective inhibition of tumor occurrence and development; in addition, by combining the near-infrared fluorescence effect and the photoacoustic effect, a multimodal combined tracing technique can be used to assist intraoperative lymph node dissection, and the drug can achieve long-term retention at the tumor site, overcoming the limitations of traditional imaging in "black box" environments of strong light or deep tissues, making it more suitable for intraoperative navigation; the system possesses good biosafety, high sensitivity, high tissue penetration and photostability, which can reduce the inconvenience of multiple clinical administrations and increase compliance.

A camera system integrated into the trocar. The camera system allows for a wide view of the internal surgical site and 3D mapping of fiducial markers during a laparoscopic procedure. Once inside the patient, the camera system is configured to deploy from a recessed position in the distal end of the trocar. In various aspects, the internal camera system is configured to keep the trocar port free for surgical instruments and provide surgical personnel with an expanded view of the surgical environment.

The application discloses a photothermal agent for treating allergic rhinitis and application of the photothermal agent in preparation of allergic rhinitis drugs. 5000 The compound 2 is prepared by reacting the compound 1 with diethylene glycol-2-bromoethyl methyl ether, then the prepared compound 2 and DSPE-mPEG 5000 are dissolved in tetrahydrofuran to perform self-assembly and form nanoparticles, the nanoparticles have a red shift of an absorption wavelength due to a strong electron-withdrawing effect of the pyridine salt group, promote intramolecular charge transfer, have deeper tissue penetration ability, can effectively reach a deep part of a nasal mucosa and treat deep inflammation; the RH@NPs prepared by the application have high efficient photothermal conversion performance and sensitivity of photodynamic therapy, so that PTT and PDT can be used in synergistic treatment of allergic rhinitis, and the treatment effect is greatly improved, and a new way for treating allergic rhinitis is opened up.

The invention discloses a near-infrared BODIPY photosensitizer, a preparation method, a pharmaceutical composition and application. The structure of the near-infrared BODIPY photosensitizer is shown as a formula (V). The invention provides the photosensitizer of which the maximum excitation wavelength and the emission wavelength are in the near-infrared band, and the photosensitizer has excellent tissue penetration depth and excellent imaging potential due to the near-infrared excitation and emission characteristics of the photosensitizer, so that the in-vivo and clinical application range is remarkably widened; the nanoparticles prepared on the basis of the photosensitizer are good in biocompatibility and high in active oxygen generation capacity, have excellent anti-tumor activity and have excellent prospects in the application of preparing tumor treatment drugs.

The present application relates to the technical field of 5-HT detection, in particular to a 5-HT near-infrared fluorescent probe and a preparation method and application thereof. The present application synthesizes a novel 5-HT near-infrared fluorescent probe, which has a longer emission wavelength (760 nm) and stronger tissue penetration, can effectively detect the level change of 5-HT in an IBD model, and can monitor the 5-HT level in IBD-related pathology in real time.

The invention discloses a multicolor fluorescent sulfur quantum dot as well as a preparation method and application thereof, and relates to the field of fluorescent quantum dots. The method comprises the following steps: mixing sodium thiosulfate, hexadecyl trimethyl ammonium bromide and sulfydryl-containing amino acid or a derivative thereof in water, and reacting the mixture in a continuous heating and stirring state; and filtering and dialyzing the obtained product to obtain pure fluorescent sulfur quantum dots. According to the method, the yellow fluorescent sulfur quantum dots are prepared for the first time, the yellow fluorescent sulfur quantum dots are also SQDs with the longest emission wavelength at present, and due to the fact that long-wavelength fluorescence has higher tissue penetrating power, the sulfur quantum dots can be better applied to tissue imaging. According to the method, sulfur powder and sodium hydroxide used as raw materials in a previous method are abandoned for the first time, sodium thiosulfate and amino acid are used as substitutes in a breakthrough mode, pure green synthesis of the quantum dots is successfully achieved, the safety and stability of the synthesis process are guaranteed, and a solid foundation is laid for industrial production of the sulfur quantum dots.

The present application provides a kind of estrogen receptor positive breast cancer fluorescent probe by parent nucleus dye nile blue derivative, estrogen receptor (ER) recognition group tamoxifen and alkane chain three parts constitute, the probe has the structure of general formula 1.The probe shows folded conformation in water environment, there is photoinduced electron transfer effect between nile blue derivative and tamoxifen, no obvious fluorescence signal;When the probe recognizes ER protein, the recognition group is combined with the binding site, the conformation of the probe changes into unfolded conformation, and strong fluorescence signal is shown.The excitation wavelength of the probe is about 630 nm, the emission wavelength is about 640-700nm, has stronger tissue penetration ability, lower tissue self-absorption and light scattering, can be targeted to breast cancer cell overexpressed ER protein, and specifically highlights estrogen receptor positive breast cancer.

A device for the destruction of viruses by means of complementary radiation, focused on weakening the lipid layer that covers some viruses, thus indirectly destroying it, this technique uses intense modulated light radiation, the main emitter being a 460 nm LED, with the technique of the invention, a secondary radiation is emitted in the 400-460 nm band, to achieve the weakening and destruction of the light, the lipid layer that covers viruses such as SARS-CoV-2, this light radiation is complemented with ultrasound pulses, completing the destruction of the virus internally, for this a technique is used that involves the emission by stratified quantum excitation, this technique uses a monochromatic LED to achieve a very high intensity multicolor emission, this emission is very controllable in terms of tissue penetration.