18 results about "Cyanine" patented technology

The present application relates to the technical field of fluorescent dyes, in particular to an asymmetric pentamethine cyanine compound. The compound comprises a structure as shown in formula I. The compound provided by the present application has good water solubility, near-infrared absorption, high fluorescence quantum yield and good molar absorption coefficient, and can be used in nucleic acid labeling, DNA sequencing, cell imaging, protein labeling or specific recognition of amino acids.

The present application relates to fluorescent nanoparticles based on fluorinated zwitterionic random copolymer and its preparation method and application, the fluorescent nanoparticles include the single chain nanoparticles formed by poly trifluoroethyl methacrylate-co-methacryloyloxyethyl sulfobetaine, the molecular chain end of the poly trifluoroethyl methacrylate-co-methacryloyloxyethyl sulfobetaine is connected with ACQ type group selected from anthryl, perylene imide group and pyrene base or AIE type group selected from tetraphenyl ethylene base, carbazole base and cyanine-containing triphenyl ethylene group.The fluorescent nanoparticles based on the poly trifluoroethyl methacrylate-co-methacryloyloxyethyl sulfobetaine of the present application that terminal fluorescent group is terminated, has excellent controllable fluorescent luminescence performance.It is considered that the single chain nanoparticles have isolation effect, avoid the fluorescence quenching effect of ACQ type group, and can provide limited microenvironment for AIE type group, ensure the fluorescent luminescence performance of nanoparticles.

The present disclosure relates in some aspects to methods and systems for analyzing a biological sample comprising contacting the biological sample with a nucleic acid probe non-covalently associated with a monomethine cyanine dye or salt thereof. In some aspects, a signal associated with the monomethine cyanine dye or salt thereof is detected to determine the location of a target analyte in the biological sample.

This invention discloses a near-infrared anthocyanin derivative based on boron cluster modification. The anthocyanin unit in the molecular structure of this derivative serves as a near-infrared fluorescence imaging and photothermal conversion unit, possessing not only near-infrared fluorescence imaging capabilities but also the ability to target tumor cells via an organic anion transport peptide-mediated pathway, enhancing selective accumulation in cancerous tissue. The nested carborane structure in the anthocyanin derivative molecular structure utilizes its strong electron-donating properties to induce photo-induced electron transfer with the anthocyanin unit, significantly improving photothermal conversion efficiency while reducing fluorescence quantum yield. The resulting molecule possesses tumor targeting, near-infrared imaging capabilities, and highly efficient photothermal and boron neutron capture therapy functions, achieving synergistic diagnostic and combined therapeutic effects of boron neutron capture therapy (BNCT) and photothermal therapy (PTT) in a single system.

A resin composition for forming a molding member included in a semiconductor package may include an epoxy resin in a range of about 2 wt % to about 10 wt %, a hardener in a range of about 2 wt % to about 10 wt %, a filler in a range of about 70 wt % to about 90 wt %, a light absorber in a range of about 0.1 wt % to about 3 wt %, and an additive in a range of about 0.1 wt % to about 3 wt %, and the light absorber includes a compound having a heptamethine cyanine structure. A method of manufacturing a semiconductor package may include forming a molding member using the resin composition.

The application discloses a tetrazine cyanine compound and a preparation method and application thereof. The skeleton of the tetrazine cyanine compound is directly connected with a BFI part of cyanine, can better affect the overall fluorescence opening multiple of the tetrazine cyanine compound by adjusting an R1 group, can also realize high-resolution imaging of a lysosome, an endoplasmic reticulum and a mitochondrial membrane by selecting a suitable R1 group and cooperating with a predetermined site molecule, can realize high fluorescence opening multiple in a near-infrared region, can significantly enhance a fluorescence emission signal from an extremely low background level after reacting with BCN, and can also have excellent light stability, wherein the fluorescence intensity of a TBCy3P addition product generated in situ is basically maintained unchanged in the whole irradiation period under continuous 100-frame laser scanning excitation, and the cell morphology is normal.

A kit, detection method, and application for detecting oligomeric single-stranded nucleic acids are disclosed. The kit is constructed based on a signal amplification strategy using a copper ion-responsive cyanine dye probe F-0 and copper oxide nanoparticles. MNPs are coupled with biotin-modified oligo1 to obtain MNPs@oligo1; disulfide-modified oligo2 is coupled with copper oxide nanoparticles to obtain CuO@oligo2. In the presence of the target nucleic acid, complementary hybridization occurs with both to form a three-dimensional sandwich structure of MNPs-target sequence-CuO. After magnetic separation and acid hydrolysis, CuO is released. 2+ The reagent is specifically recognized by the cyanine dye probe F-0 and generates a spectral response, enabling rapid detection of target nucleic acids. Using miRNA as a model, the detection limit can reach 1.5 fM. This kit is easy to use, highly sensitive, and has good specificity, making it suitable for the detection of various oligomeric single-stranded nucleic acids, including miRNAs, nucleic acid aptamers, and antisense oligonucleotides.

The present invention aims to provide a resin composition which is a melt mixture of a near-infrared absorbing dye and a resin, and which can produce a molded body having good optical properties even when melt-molded. The present invention is a resin composition characterized by being a melt mixture of a resin and a cyanine dye and / or a squarylium cyanine dye, the cyanine dye being a compound containing a cation composed of a cyanine structure and an anion composed of tetra(pentafluorophenyl)borate, the cation composed of a cyanine structure having a specific structure or having a specific structure at at least one terminal of a polymethine skeleton, the squarylium cyanine dye being a compound having the following structure: at least one of the structures attached to the squarylium site contains a nitrogen-containing conjugated system composed of a five-membered ring and a six-membered ring; or, at least one of the structures attached to the squarylium site contains a nitrogen-containing conjugated system composed of a five-membered ring and a six-membered ring via one conjugated carbon.

Disclosed are a cyanine-derived compound, a preparation method therefor, and application thereof. The compound has the structure represented by formula (1), and the preparation method for the compound is further disclosed. The series of compounds of the present invention can be used as fluorescent markers for live-cell imaging analysis or flow cytometric analysis, solving problems of high toxicity, high cost and poor imaging effect of current.

The utility model discloses a power battery disassembling practical training device relates to the technical field of automobile repair teaching, including the outer package shell, the inside of outer package shell is provided with the simulation battery shell, the inside of simulation battery shell is provided with the detection block, the below of detection block is provided with the gas tank, and the gas tank can push the detection block above the gas pressure shell through the air pressure, when the battery is collided or is forced too much, will extrude the detection block properly, because detection block adopts spiropyran compound, when extruding, the spiro ring structure in molecule is opened under the mechanical force, forms the department flower cyanine structure of planar type, leads to the change (such as from colorless to colored) of absorption spectrum, and further can judge whether the student appears the effect of too violent in the disassembling process through the color change of detection block, thereby solves the problem that cannot judge whether too violent or collision leads to the battery damage in the disassembling process through the simulation battery.

This invention discloses a stereoconformation group-modified heptamethrin derivative and its application. Belonging to the field of chemical pharmaceuticals, this invention provides micro / nano structures formed by the self-assembly in aqueous solution of structures with the structures shown in formulas (I), (II), (III), and (IV) or their isomers, pharmaceutically acceptable salts, hydrates, or solvates, as well as the preparation of pharmaceutical compositions and their application in the preparation of fluorescent probes and phototherapy drugs. The compounds provided by this invention can accumulate at tumor sites and can achieve aggregation structure transformation and optical property regulation through stereoconformation group modulation. Under irradiation with a specific excitation wavelength, it achieves precise photothermal / photodynamic combined therapy of tumors in the aggregated state and low-background long-lasting fluorescence imaging at the tumor site after aggregation disintegration. It has good tumor treatment effect, minimal trauma, high fluorescence imaging accuracy, and long duration, achieving integrated diagnosis and treatment of tumor sites while possessing excellent biosafety.

The application belongs to the field of biomedical detection and molecular imaging technology, and specifically discloses a water-soluble low-background Cy5 probe, a construction method thereof and application of the probe to consistent hypochlorous acid detection across instruments. The probe Cy5Q1-HClO of the application takes Cy5 cyanine dye as a skeleton, realizes near-zero intrinsic fluorescence by means of a double photo-induced electron transfer (PET) mechanism, triggers a self-elimination cascade reaction after specific recognition of hypochlorous acid, and restores strong near-infrared fluorescence. The double-cation structure of the probe endows it with good water solubility, facilitating its use in biological systems. The spectral shift of the probe is extremely small before and after response, only the absorption and fluorescence intensity change, so similar working curves can be obtained on instruments with different excitation and detection channels, the probe has cross-platform and instrument-independent signal quantitative capability, thereby realizing high-sensitivity, zero-background interference and in-vivo precise imaging of HClO. The probe has the characteristics of water solubility, low background and high sensitivity, can not only visualize tumors with high contrast, but also guide precise resection of less than 2mm resection margin, and for the first time realizes longitudinal monitoring of dynamic changes of HClO in the postoperative wound healing process. The application also provides a preparation method and application of the Cy5Q1-HClO probe.

This invention discloses a photocurable, highly stable titanium cyanide dye for color photoresists and its application in color photoresist compositions and filters, belonging to the field of photoresist technology. The composition includes a reactive dye, a polymerizable monomer, a photoinitiator, and a solvent. The reactive dye molecule contains olefinic unsaturated double bonds, which can react with the polymerizable monomer during photocuring to form a dense cross-linked network, thereby firmly anchoring the dye molecules within it through chemical bonding, fundamentally solving the problems of poor thermal and light stability of traditional dyes. This invention also provides a method for quantitatively evaluating the photothermal and light stability of the composition. The composition prepared by this invention exhibits excellent solvent resistance, thermal stability, and light stability, making it suitable for the manufacture of high-end display panels.

The present invention relates to fluorescent dyes in general. The present invention provides a wide range of fluorescent dyes and kits containing the same, which are applicable for labeling a variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis, and / or treatment of disease conditions.

The application discloses an anchor COX-2 protein responsive photosensitizer and a preparation method and application thereof, relates to the technical field of biological medicine and disease treatment. The compound IRID-SS shown in formula (I) prepared by the application is provided with a near-infrared cyanine as a photosensitive unit, an indomethacin as a COX-2 targeting ligand and a disulfide bond as a glutathione response unit. The compound can be activated under the condition of high glutathione in a tumor microenvironment, specifically anchors Golgi COX-2 protein, generates reactive oxygen species in situ through near-infrared laser irradiation, realizes irreversible oxidative damage of COX-2 protein, and induces pyroptosis of tumor cells through a Caspase-3 / GSDME channel. The compound has a simple synthesis method, does not introduce toxic reagents, does not have the problem of toxic reagent residue, has high biological safety, and therefore has good practical application value.

The application discloses a chitosan-cyanine / carboxylated graphene oxide film and a preparation method thereof. The application uses a glass slide as a substrate, alternately assembles chitosan with opposite charges and carboxylated graphene oxide on the substrate, and dries the film to obtain a layer-by-layer self-assembly film with different double layers. The modified film has greatly improved ultraviolet blocking capacity, maintains good transparency, and has enhanced mechanical performance and water blocking performance, and has good antioxidant performance. The application selects carboxylated graphene oxide as an assembly material for the first time, and has the advantages of mild conditions, simple process, no introduction of other impurities in the modification process, no generation of other by-products and the like.