33 results about "Localized Therapy" patented technology

The present invention relates to systems and methods for localized delivery of heat, useful for localized imaging and treatment of a biological material. The systems and methods of the invention can be utilized for localized treatment of cancer, inflammation or other disorders involving over proliferation of tissue, and for tissue repair. The method comprises exposing nanoparticles to electromagnetic radiation under conditions wherein the nanoparticles generate microbubbles which emit heat when exposed to ultrasonic radiation.

A therapeutic medical article is provided which comprises a medical article, a precursor compound and an activator compound. The medical article is adapted, upon administration to a patient, to release the precursor compound and the activator compound such that the activator compound interacts with the precursor compound and converts the precursor compound into activated form for local delivery. Specific examples of precursor and activator compound pairs include: (a) a nitrosothiol precursor and a nitric oxide donor, (b) plasminogen and plasminogen activator, and (c) fibrinogen and thrombin.

Dye-peptide conjugates useful for diagnostic imaging and therapy are disclosed. The dye-peptide conjugates include several cyanine dyes with a variety of bis- and tetrakis(carboxylic acid) homologues. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350-1300 nm, the exact range being dependent upon the particular dye. Use of dimethylsulfoxide helps to maintain the fluorescence of the compounds. The molecules of the invention are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities and for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

A comprehensive localized therapy method and equipment for tumor features that various endoscopes are used to inject the magnetic immune microspheres carrying biologic medicine and the antineoplastic magnetic chemical medicine into tumor focus, the liquid radioactive source is poured in the inner cavity of catheter, and an alternative magnetic field is generated around the tumor focus to induce the microspheres to generate heat and adsorbing the antineoplastic medicine to round the tumor focus. Its advantage is the combination of biotherapy, chemicotherapy, radiotherapy and thermotherapy.

Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

An enzymatically active medical article is provided, which comprises a medical article and an enzyme disposed at or near a surface of the medical article such that the medical article is provided with an enzymatically active surface. The enzyme is selected, for example, from the group consisting of protease enzymes, glycosidase enzymes, enzymes that degrade cholesterol esters, enzymes that convert hydrocortisone to cortisone, enzymes that degrade oxalate, and enzymes that generate NO from arginine.

The invention discloses a multifunctional sonic wave therapeutic instrument, comprising a host, two or more sonic wave therapeutic heads and one or more pairs of electrode plates, wherein the therapeutic heads and the electrode plates are put on the fourteen meridians, acupuncture point or many parts of the body surface for doing whole treatment or local treatment. The instrument has two functions of sonic wave treatment and bioelectric treatment, which has several purposes and can be shared by several persons; two functions can be acted on the human body at the same time so that the instrument saves the resources and the time, increases the effect and is convenient and practical. Especially the instrument does local or whole treatment on the human body by means of scientifically and orderly arranging the sound source signals of heaven five-element corresponding to the human body into multiple independent or combined acoustic signals via a microcomputer processor (2) according to the yin-yang five-element theory of traditional Chinese medicine science, operating the signals by a control panel (3), and amplifying the acoustic signals via an audio power amplifier circuit (6), and arranging the signals on the corresponding parts of the body surface to treat the human body via a sonic wave therapeutic head (8) according to the sound transmission characteristics of the main and collateral channels.

Liquid or semi-liquid pharmaceutical compositions for topically treating immune-mediated skin disorders such as psoriasis, eczema, acne, dermatitis, and skin cancer and methods of treating patients having such immune-mediated skin disorders using the compositions.

A method and system for optimizing an IMPT plan are provided, as well as a computer program product for performing, and an arrangement for planning IMPT. For optimizing the IMPT plan, the following steps are performed. An initial IMPT plan is received, along with anatomical image data of the subject to be treated. Critical proton spots are identified in the initial plan using the anatomical image data. At least one local plan deficiency area associated with the identified critical proton spots is generated. A local treatment plan is then generated for the LPDA by applying robust optimization to it. The optimized treatment plan for delivery to the subject to is then generated by combining the local treatment plan with the initial IMPT plan.

Method for treatment of the body with localized energy application in combination with other treatments to facilitate cluster tissue ablation and increase immune response including a method of treatment of a localized treatment area of a body including injection, IV or otherwise to entrap and/saturate a localized treatment area to be used singularly or in combination with: a high electric conductive material comprising a saline solution, hypertonic saline solution, a solution with metallic compounds, metals, nanoparticles, gel, polymers, high-polarity molecules, peptides, liposomes to treat and cause preferential heating and effect secondary conductive heating from cluster sites to adjacent tissues using external or intracavitary energy applicators.