416 results about "Valve leaflet" patented technology

The present invention discloses a presettable artificial biological aortic valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3), wherein the valve seat (1) is a one-way limiting expandable annular metal seat; the head end of each seat body unit (4) is sequentially provided with a first rivet (7), a limiting protrusion (6) and a first long circular groove (5) from the outside to the inside; the tail end of each seat body unit (4) is sequentially provided with a second long circular groove (8), a second limiting hole (10) and a first limiting hole (9) matched with the limiting protrusion (6), and a second rivet (11) matched with the first long circular groove (5). The presettable artificial biological aortic valve has an original preset state and a normal use state after one-way limiting expansion.

A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including a plurality of leaflets is disclosed. As one example, a prosthetic heart valve includes a frame; a plurality of commissure support elements, each connected the frame and including two axially-extending members spaced apart from one another to form a window; and a plurality of leaflets, each leaflet comprising a body and two opposing commissure tabs, each commissure tab arranged adjacent to another commissure tab to form a pair of commissure tabs that are disposed in a commissure support element to form a commissure. Each commissure tab includes a series of overlapping layers that include a first set of two overlapping layers that extends through the window and a second set of two overlapping layers that extends away from the first set of two overlapping layers and over an outer side of a corresponding axially-extending member.

The invention discloses a valve clamping device. The valve clamping device comprises a fixed seat; the first clamping piece and the second clamping piece are hinged to the fixed seat; the clamping assembly comprises a connecting base, a first elastic piece assembly and a second elastic piece assembly, the first elastic piece assembly and the second elastic piece assembly extend out of the two opposite sides of the connecting base, and the fixing base is contained in the connecting base; the first elastic piece assembly and the second elastic piece assembly are matched with the first clamping piece and the second clamping piece respectively to clamp a valve leaflet of a valve, the first elastic piece assembly and the second elastic piece assembly each comprise a clamping elastic piece and a detection elastic piece, and when the clamping elastic pieces are matched with the first clamping piece or the second clamping piece to clamp the valve leaflet, the detection elastic pieces are arranged on the clamping elastic pieces. The detection elastic pieces on the same side can be controlled to move between the joint state where the detection elastic pieces are jointed with the valve leaflet and the detection state where the detection elastic pieces are separated from the valve leaflet so as to detect whether the valve leaflet is clamped at the expected position or not by the clamping elastic pieces and the first clamping piece or the second clamping piece in a matched mode. The invention further provides a valve clamping system using the valve clamping device and a method for detecting the clamping state of the clamping assembly.

A clip for immobilizing leaflets of a cardiac or venous valve includes a hub having a pair of tangle resistant spring-biased outer arms coupled to an inferior end of the hub and a pair of tangle resistant spring-biased inner arms adjacent to the outer arms and coupled to a superior end of the hub. A delivery catheter may be used to position the valve clip adjacent a target valve while the outer and inner arms are biased in an opened position relative to each other. After the valve leaflets are located between the opened outer and inner arms, the biasing forces may be released to allow the clip to self-close the clip over the valve leaflets.

The transcatheter type artificial polymer heart valve comprises an integrated valve leaflet and a valve frame, the valve frame is of a hollow columnar grid structure, the valve frame is provided with a first end and a second end, the first end is provided with a plurality of stand columns at intervals in the circumferential direction, the integrated valve leaflet comprises a pipe body and a valve leaflet, the pipe body is provided with a third end and a fourth end, and the valve leaflet is arranged in the pipe body. The valve leaflets are arranged in the center of the third end, the valve leaflets are sequentially arranged in the circumferential direction, connecting grooves are formed in the connecting positions of the adjacent valve leaflets, and the connecting grooves are provided with through holes allowing the stand column to penetrate through; a connecting column is arranged on the outer wall of the pipe body, and a connecting hole matched with the connecting column is formed in the petal frame; when the integrated valve leaflet is arranged in the valve frame, the third end and the fourth end correspond to the first end and the second end respectively, the stand columns are inserted into the through holes, and the connecting columns are connected with the connecting holes in a one-to-one correspondence mode. Manual valve sewing is reduced, and the assembly efficiency is improved; stress concentration during opening and closing of the valve leaflet is reduced, and the performance of the valve is optimized.

The invention relates to the technical field of cardiovascular examination, in particular to a cardiovascular ultrasonic examination quality control method and system based on artificial intelligence, and the method comprises the following steps: obtaining a valve motion image through ultrasound, extracting a valve leaflet edge coordinate, recognizing a valve opening center and a valve leaflet tip through a convolutional neural network, and generating motion data; the method comprises the following steps: calculating a deviation degree based on trajectory fitting, judging stability, analyzing peak values of a systolic period and a diastolic period, calculating a symmetry difference, extracting a valve opening area, carrying out self-encoder analysis in combination with the symmetry difference to generate a fluctuation amplitude, and carrying out normalization processing to complete hierarchical classification so as to generate a quality control result. By acquiring leaflet edge points and combining a convolutional neural network to identify key features, accurate extraction of motion data, finer trajectory fitting and offset calculation, more scientific quantitative evaluation of symmetry difference and more stereoscopic area fluctuation and feature fusion analysis are realized, hierarchical and hierarchical synchronization is realized through normalization processing, and the accuracy of the motion data is improved. And the result is more credible, more stable and higher in clinical value.

A packaging assembly for storing a prosthetic heart valve can comprise a valve tray comprising an annular rim and a cavity extending away from the annular rim, wherein the cavity is configured to accept the prosthetic heart valve. The packaging assembly can further comprise a lid configured to cover the annular rim. The packaging assembly can further comprise a leaflet biasing element disposed on a central portion of the lid. The leaflet biasing element can comprise an extrusion with a paraboloid shape that can extend from a lower surface of the lid towards the valve tray. The leaflet biasing element can be configured to extend at least partially into an inflow end portion of the prosthetic heart valve and secure a plurality of leaflets of the prosthetic heart valve in a desired configuration when the prosthetic heart valve is inserted in the cavity and the lid is closed over the annular rim.

An implantable device to be positioned within a heart valve, using a delivery system comprising catheters. The device can include leaflet anchors for attaching to valve leaflets. One or more tethers can be slackened to allow the anchors to move relatively apart and / or relatively away from a spacer. The one or more tethers can be pulled to move the anchors closer to one another or and / or closer to the spacer.

Prosthetic heart valve leaflets of shapes that control bending. Prosthetic heart valves can include a leaflet frame having a generally tubular shape with attached film. The leaflet frame can define a plurality of leaflet windows with the film defining at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame may have substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides can diverge from the leaflet base, the leaflet base being substantially flat.

A fixation device for fastening to a native heart valve having native valve leaflets, the fixation device comprising: (a) a device body, and (b) at least one clamp on the device body, the clamp for engaging and holding a native valve leaflet, the clamp comprising at least one moveable jaw, the moveable jaw having thereon at least one gripping element which is moveable relative to the moveable jaw between a native valve leaflet gripping configuration of the moveable jaw where the gripping element is arranged to grip a native valve leaflet and a passive configuration of the moveable jaw where the gripping element is arranged so that it cannot grip a native valve leaflet. This provides a device that can be repositioned during a medical procedure.

The invention provides a valve leaflet lengthening device which comprises a conveying catheter, a first clamping arm, a second clamping arm, an opening and closing rod and a locking assembly, the first clamping arm is fixedly arranged at the far end of the conveying catheter, and the second clamping arm is rotationally connected to the near end of the first clamping arm; the opening and closing rod is connected to the near end of the second clamping arm and used for opening or closing the second clamping arm; the locking assembly comprises a blocking piece and a push rod connected with the blocking piece. The push rod is used for driving the blocking piece to move to prevent the second clamping arm from being opened. According to the valve leaflet extension device, the opening and closing rod and the locking assembly are arranged, so that the push rod drives the blocking piece to move so as to prevent the second clamping arm from being opened, and the technical problem that the second clamping arm is expanded and cocked up in the puncture process, and consequently an operation fails is solved.

Embodiments herein relate to methods of attaching leaflets to a valve frame and valves made using the same. In an embodiment, a method of making an implantable prosthetic valve is included. The method can include compressing at least a portion of valve leaflet tabs, inserting the compressed valve leaflet tabs into commissural slots of a valve frame, and expanding the compressed valve leaflet tabs. Other embodiments are also included herein.

Leaflets for a prosthetic heart valve are disclosed. As one example, a leaflet includes a main body with a free, outflow edge and a cusp edge portion, two lower tabs disposed on opposite sides of the main body, where the cusp edge portion terminates at upper ends thereof at the lower tabs, and the lower tabs extend laterally outward from the main body relative to a central longitudinal axis of the leaflet, and two upper tabs disposed on opposite sides of and extending laterally outward from the main body. The leaflet further includes two offsetting portions, each extending between a respective lower tab and upper tab and offsetting the respective upper tab axially and laterally away from the outflow edge of the main body, where each upper tab has opposing inner and outer edges that are parallel to one another and the central longitudinal axis of the leaflet.

The invention discloses a valve clamping device with adjustable bearing force and a valve clamping system. The valve clamping device comprises a supporting part and a clamping part, the hollow adjusting part is made of a shape memory material, one end of the adjusting part is arranged on the outer side of the supporting part in a sleeving mode and connected with the supporting part, and the other end of the adjusting part can move along the supporting part; the clamping part is arranged on the outer side of the adjusting part in a surrounding manner; the driving part is connected with the clamping part so as to drive the clamping part to be unfolded or folded around the adjusting part; when the clamping part is closed relative to the adjusting part, the near end of the adjusting part does not exceed the near end of the clamping part. Therefore, by means of the valve clamping device, the elastic fitting performance of the valve leaflet and the adjusting part can be improved, and then the adaptability of valve leaflet physiological structures of different patients is improved.

A valve fixation device may comprise a unitary elongate member that is biased towards a closed configuration wherein at least a pair of tissue engaging surfaces of the elongate member are held adjacent to each other by a bias force. The bias force is at least equal to a valve leaflet grasping force, enabling the fixation device to grasp and retain leaflets as part of cardiac treatment. A delivery tool including a spreader may independently translate the tissue engaging surfaces to enable cardiac leaflets to be captured and retained by and / or between the tissue engaging surfaces. The valve fixation device may include at least two arms, each of which may be independently controlled to grasp and capture opposing leaflets of a valve, such as the anterior and posterior leaflets of a mitral valve, to reduce the size of the valve opening and improve cardiac performance.

Prosthetic heart valves and methods for assembling prosthetic heart valves are disclosed. As one example, a prosthetic heart valve includes a frame, commissure support elements, and leaflets, each leaflet comprising a body and opposing commissure tabs, each commissure tab folded over from a corresponding body to form a bend between the commissure tab and body and arranged adjacent to another folded commissure tab of an adjacent leaflet to form a pair of commissure tabs that is coupled to one commissure support element to form a commissure. Each commissure tab is secured to the commissure support element via a reinforcement member positioned against the commissure tab, adjacent to the bend, and secured to and / or at least partially wrapped around the commissure tab and the commissure support element, the reinforcement member comprising a flexible body and a more rigid, central portion, the central portion positioned along a height of the commissure tab.

The utility model provides a valve clamping device and a clamping system, the valve clamping device comprises a clamping component used for clamping a valve leaflet and a plugging piece matched with the clamping component and used for plugging, the clamping component comprises a pair of clamping assemblies capable of being opened or closed, the plugging piece can deform and self-expand, and the clamping component is used for clamping the valve leaflet. The plugging piece comprises a main plugging part and a side plugging part connected to the side portion of the main plugging part, the pair of clamping assemblies are oppositely located on the outer side of the main plugging part and can be opened or closed relative to the main plugging part, and the self-expanded main plugging part can be matched with the clamping assemblies to form a first plugging area when the clamping assemblies are closed. The self-expanded side plugging part extends in the width direction of the clamping component and can be filled in the ventage located on the adjacent side of the first plugging area to form a second plugging area when the clamping component is closed. The utility model aims at providing the valve clamping device and the clamping system to at least improve the anti-reflux effect at the junction of the valve leaflets.

Disclosed herein are a high-molecular artificial heart valve and a preparation method therefor, relating to the technical field of medical instruments. The high-molecular artificial heart valve comprises a frame, a skirt arranged on the surface of the frame, and valve leaflets bonded with the skirt. The preparation method therefor comprises the following steps: after the skirt is prepared on the frame, arranging a part of the valve leaflets on the surface of at least a part of the edge of the skirt, or connecting the edges of the valve leaflets with the at least a part of the skirt, and then bonding the valve leaflets with the edge of the skirt by means of interface microtreatment. The interface microtreatment is achieved by means of a polymer solution that bonds the valve leaflets with the edge of the skirt or by utilizing thermal bonding between the valve leaflets and the edge of the skirt. The valve prepared by the method has the advantages of uniform structure and high strength, effectively improving the production quality of the valve.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

A prosthetic valve component is disclosed for a valve prosthesis. The valve component includes valve leaflets configured to be operably coupled within a frame of the valve prosthesis, wherein each valve leaflet is shaped and sized to achieve a target pinwheeling score PS. The target pinwheeling score correlates to full contact being made between free edges of the valve leaflets, when the valve leaflets are operably coupled within the frame of the valve prosthesis, such that no central opening and little to no overlap occurs between the valve leaflets.

Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a ventricular winding having a generally spiral shape, wherein the device is free of any atrial stabilizing section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the ventricular winding and turning the ventricular winding such that the chords move closer to the center of the ventricular winding. The ventricular winding draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing. A delivery system for maneuvering and releasing a heart valve repair device comprises an applicator tube and internal rod.

The invention discloses an artificial valve, a valve leaflet for the artificial valve and a preparation method of the valve leaflet, the valve leaflet comprises a body, the edge part comprises a free edge and a fixed edge which are opposite, and the body is made of a first high polymer material; the first reinforcing edge is distributed along the fixing edge, the first reinforcing edge is made of a second high polymer material and is provided with a pore structure, and the first high polymer material enters the pore structure and is fixed with the first reinforcing edge. The artificial valve leaflet is good in blood compatibility, high in tearing strength and long in service life, and the effective opening area and the reflux ratio of a valve made of the valve leaflet are better.

The invention provides an artificial valve. The artificial valve comprises a valve frame, at least two valve leaflets and a suture ring assembly. The valve frame comprises valve feet, a flange structure and a combination layer, and at least two valve feet are installed on the inner side face of the flange structure; all the petal feet are connected in sequence to form an annular structure; a plurality of suture holes are formed in the top surface of the flange structure; the outer surface of the valve frame is coated with the bonding layer; all the valve leaflets are arranged in the annular structure and are connected with the bonding layer; a fiber layer is arranged on the outer surface of the valve leaflet; the valve leaflet is made of a polyurethane material; the suture ring assembly wraps the outer side face of the flange structure. The valve leaflet of the artificial valve can have better fatigue resistance, anticoagulation and the like, and the risk of calcification of the valve leaflet after implantation can be reduced. The binding layer can enhance the binding force between the valve frame and the valve leaflet; a fiber layer is formed on the surface of the valve leaflet and can enhance the mechanical performance of the valve leaflet.

An implant (150) comprises a patch (210), a patch anchor (240), a downstream assembly (300) comprising a winch (320) coupled to a winch anchor (310), and a tether (160) tethering the winch to the patch. A delivery tool (400) has a distal portion that is transluminally advanceable to a heart while the implant is mounted on the delivery tool. The delivery tool has a shaft, a clasp (430), comprising an upstream support and a downstream support, the clasp configured to grasp a portion of a leaflet of a valve of the heart between the upstream support and the downstream support of the clasp, and a driver, configured to anchor the patch to the portion of the leaflet using the patch anchor while the portion of the leaflet remains grasped by the clasp. Other embodiments are also described.

A clip for securing leaflets of a heart or vein valve includes a hub having a pair of anti-tangling spring-biased outer arms coupled to a lower end of the hub. A pair of anti-entanglement spring-biased inner arms are adjacent to the outer arms and coupled to the upper end of the hub. The clip may incorporate an adjustable spacer and may be retrieved after implantation. When the outer arm and the inner arm are biased relative to each other in an open position, a delivery catheter is used to position the valve clip proximate a target valve. After the valve leaflet is located between the open outer and inner arms, the biasing force may be released to allow the clip to self-close on the valve leaflet.

According to the anchoring piece, the restraining device, the conveying system and the conveying method, the anchoring piece adopts an anchoring clamp clamping mode, can adapt to more pathological structures, and can effectively treat aortic valve regurgitation (or aortic valve divalvular and tetravalvular deformity accompanied by aortic valve divalvular and tetravalvular deformity) patients; the protruding anchor is arranged to hang or carry the autologous valve leaflet, valve displacement is prevented, and the perivalvular leakage risk is reduced. The restraining device is provided with a restraining part, the anchoring part is sleeved with a restraining section of the restraining part in an annular shape, a scaling section is connected with the restraining section and arranged in the releasing pipe in a penetrating mode, and the restraining force of the restraining section on the anchoring part is controlled by controlling the scaling section so as to control the releasing speed of the anchoring part. The delivery system optimizes the structure and the function of the whole system, a lumen gap can be properly widened, emptying and water passing are facilitated, the delivery system has better control force when the artificial valve is released due to introduction of the restraining device, and it is guaranteed that when the anchoring piece reaches the lesion position, the anchoring piece is slowly placed, and the aorta and the sinus floor are prevented from being damaged.

Embodiments herein relate to polymer coated prosthetic heart valves. In an embodiment, a method of manufacturing a heart valve is included, the method obtaining a frame, attaching a porous web to the frame, applying a coating over at least a portion of the porous web. In an embodiment a heart valve is included. The heart valve including a frame and a plurality of valve leaflets attached to the frame. Each valve leaflet can have a first polymer forming a porous support web and a second polymer forming a coating occluding pores in the porous support web. The valve leaflets can be attached to the frame with a connection structure that is at least partially covered by the coating. Other embodiments are also included herein.

Provided is a prosthetic valve replacement system. A hoop member is at least partially disposed on a valve clamping mechanism. A valve clamping and securing mechanism is configured to present a first form and a second form, and the second form is present after the first form. When the valve clamping and securing apparatus is in the first form, the valve clamping mechanism is configured to capture and clamp autologous valve leaflets. After the radial expansion of a valve stent, the valve clamping and securing apparatus is in the second form.

A replacement heart valve system may include a replacement heart valve implant comprising an expandable framework configured to shift from a radially collapsed configuration to a radially expanded configuration, and a plurality of valve leaflets disposed within and secured to the framework, and an implant delivery system comprising a handle assembly and an elongate shaft assembly extending distally from the handle assembly. The elongate shaft assembly may include an inner shaft axially secured to the handle assembly, an outer tubular member axially secured to the handle assembly and disposed about the inner shaft, and an implant holding portion. The implant holding portion is configured to constrain the implant in the radially collapsed configuration when the implant holding portion is disposed in a delivery configuration, wherein the implant holding portion is rotatable relative to the outer tubular member.

A device and method of inhibiting and preventing damage to leaflets during the crimping of a prosthetic valve, and / or facilitating the folding of the leaflets during the crimping of a prosthetic valve.