294 results about "Valve leaflet" patented technology

The present invention discloses a presettable artificial biological aortic valve which comprises a valve seat (1), a valve leaflet stent (2) and three valve leaflets (3), wherein the valve seat (1) is a one-way limiting expandable annular metal seat; the head end of each seat body unit (4) is sequentially provided with a first rivet (7), a limiting protrusion (6) and a first long circular groove (5) from the outside to the inside; the tail end of each seat body unit (4) is sequentially provided with a second long circular groove (8), a second limiting hole (10) and a first limiting hole (9) matched with the limiting protrusion (6), and a second rivet (11) matched with the first long circular groove (5). The presettable artificial biological aortic valve has an original preset state and a normal use state after one-way limiting expansion.

A prosthetic heart valve and associated methods for assembling a prosthetic heart valve including a plurality of leaflets is disclosed. As one example, a prosthetic heart valve includes a frame; a plurality of commissure support elements, each connected the frame and including two axially-extending members spaced apart from one another to form a window; and a plurality of leaflets, each leaflet comprising a body and two opposing commissure tabs, each commissure tab arranged adjacent to another commissure tab to form a pair of commissure tabs that are disposed in a commissure support element to form a commissure. Each commissure tab includes a series of overlapping layers that include a first set of two overlapping layers that extends through the window and a second set of two overlapping layers that extends away from the first set of two overlapping layers and over an outer side of a corresponding axially-extending member.

The transcatheter type artificial polymer heart valve comprises an integrated valve leaflet and a valve frame, the valve frame is of a hollow columnar grid structure, the valve frame is provided with a first end and a second end, the first end is provided with a plurality of stand columns at intervals in the circumferential direction, the integrated valve leaflet comprises a pipe body and a valve leaflet, the pipe body is provided with a third end and a fourth end, and the valve leaflet is arranged in the pipe body. The valve leaflets are arranged in the center of the third end, the valve leaflets are sequentially arranged in the circumferential direction, connecting grooves are formed in the connecting positions of the adjacent valve leaflets, and the connecting grooves are provided with through holes allowing the stand column to penetrate through; a connecting column is arranged on the outer wall of the pipe body, and a connecting hole matched with the connecting column is formed in the petal frame; when the integrated valve leaflet is arranged in the valve frame, the third end and the fourth end correspond to the first end and the second end respectively, the stand columns are inserted into the through holes, and the connecting columns are connected with the connecting holes in a one-to-one correspondence mode. Manual valve sewing is reduced, and the assembly efficiency is improved; stress concentration during opening and closing of the valve leaflet is reduced, and the performance of the valve is optimized.

The invention relates to the technical field of cardiovascular examination, in particular to a cardiovascular ultrasonic examination quality control method and system based on artificial intelligence, and the method comprises the following steps: obtaining a valve motion image through ultrasound, extracting a valve leaflet edge coordinate, recognizing a valve opening center and a valve leaflet tip through a convolutional neural network, and generating motion data; the method comprises the following steps: calculating a deviation degree based on trajectory fitting, judging stability, analyzing peak values of a systolic period and a diastolic period, calculating a symmetry difference, extracting a valve opening area, carrying out self-encoder analysis in combination with the symmetry difference to generate a fluctuation amplitude, and carrying out normalization processing to complete hierarchical classification so as to generate a quality control result. By acquiring leaflet edge points and combining a convolutional neural network to identify key features, accurate extraction of motion data, finer trajectory fitting and offset calculation, more scientific quantitative evaluation of symmetry difference and more stereoscopic area fluctuation and feature fusion analysis are realized, hierarchical and hierarchical synchronization is realized through normalization processing, and the accuracy of the motion data is improved. And the result is more credible, more stable and higher in clinical value.

An implantable device to be positioned within a heart valve, using a delivery system comprising catheters. The device can include leaflet anchors for attaching to valve leaflets. One or more tethers can be slackened to allow the anchors to move relatively apart and / or relatively away from a spacer. The one or more tethers can be pulled to move the anchors closer to one another or and / or closer to the spacer.

Prosthetic heart valve leaflets of shapes that control bending. Prosthetic heart valves can include a leaflet frame having a generally tubular shape with attached film. The leaflet frame can define a plurality of leaflet windows with the film defining at least one leaflet extending from each of the leaflet windows. Each leaflet attachment zone on the leaflet frame may have substantially the shape of an isosceles trapezoid having two leaflet sides, a leaflet base and a leaflet free edge opposite the leaflet base. The two leaflet sides can diverge from the leaflet base, the leaflet base being substantially flat.

The invention provides a valve leaflet lengthening device which comprises a conveying catheter, a first clamping arm, a second clamping arm, an opening and closing rod and a locking assembly, the first clamping arm is fixedly arranged at the far end of the conveying catheter, and the second clamping arm is rotationally connected to the near end of the first clamping arm; the opening and closing rod is connected to the near end of the second clamping arm and used for opening or closing the second clamping arm; the locking assembly comprises a blocking piece and a push rod connected with the blocking piece. The push rod is used for driving the blocking piece to move to prevent the second clamping arm from being opened. According to the valve leaflet extension device, the opening and closing rod and the locking assembly are arranged, so that the push rod drives the blocking piece to move so as to prevent the second clamping arm from being opened, and the technical problem that the second clamping arm is expanded and cocked up in the puncture process, and consequently an operation fails is solved.

Leaflets for a prosthetic heart valve are disclosed. As one example, a leaflet includes a main body with a free, outflow edge and a cusp edge portion, two lower tabs disposed on opposite sides of the main body, where the cusp edge portion terminates at upper ends thereof at the lower tabs, and the lower tabs extend laterally outward from the main body relative to a central longitudinal axis of the leaflet, and two upper tabs disposed on opposite sides of and extending laterally outward from the main body. The leaflet further includes two offsetting portions, each extending between a respective lower tab and upper tab and offsetting the respective upper tab axially and laterally away from the outflow edge of the main body, where each upper tab has opposing inner and outer edges that are parallel to one another and the central longitudinal axis of the leaflet.

Prosthetic heart valves and methods for assembling prosthetic heart valves are disclosed. As one example, a prosthetic heart valve includes a frame, commissure support elements, and leaflets, each leaflet comprising a body and opposing commissure tabs, each commissure tab folded over from a corresponding body to form a bend between the commissure tab and body and arranged adjacent to another folded commissure tab of an adjacent leaflet to form a pair of commissure tabs that is coupled to one commissure support element to form a commissure. Each commissure tab is secured to the commissure support element via a reinforcement member positioned against the commissure tab, adjacent to the bend, and secured to and / or at least partially wrapped around the commissure tab and the commissure support element, the reinforcement member comprising a flexible body and a more rigid, central portion, the central portion positioned along a height of the commissure tab.

Disclosed herein are a high-molecular artificial heart valve and a preparation method therefor, relating to the technical field of medical instruments. The high-molecular artificial heart valve comprises a frame, a skirt arranged on the surface of the frame, and valve leaflets bonded with the skirt. The preparation method therefor comprises the following steps: after the skirt is prepared on the frame, arranging a part of the valve leaflets on the surface of at least a part of the edge of the skirt, or connecting the edges of the valve leaflets with the at least a part of the skirt, and then bonding the valve leaflets with the edge of the skirt by means of interface microtreatment. The interface microtreatment is achieved by means of a polymer solution that bonds the valve leaflets with the edge of the skirt or by utilizing thermal bonding between the valve leaflets and the edge of the skirt. The valve prepared by the method has the advantages of uniform structure and high strength, effectively improving the production quality of the valve.

The invention discloses a TAVR postoperative blood flow parameter complementing method based on CT-MRI fusion, and belongs to the technical field of crossing of medical image processing and computational fluid mechanics. A CT valve frame registration technology is adopted, an invisible artificial valve leaflet three-dimensional structure is reconstructed through valve frame information in a CT image and is coupled with a dynamic heart model, a complete valve mechanical and functional simulation platform is constructed, the problem of an imaging blind area is solved, hemodynamic parameters of an inlet and an outlet of a postoperative area are further collected in combination with 4D Flow MRI, and the artificial valve leaflet three-dimensional structure is obtained. The blood flow conditions of the upstream and the downstream of the artificial valve area at each stage of contraction and relaxation of the TAVR postoperative part are comprehensively restored, the temporal-spatial resolution and the physical authenticity of the boundary condition in fluid-solid coupling simulation are greatly improved, and the more real passive response of the valve leaflet under the action of the blood flow is obtained; and a reliable basis is provided for quantitative and mechanical risk analysis of postoperative complications such as thrombosis, perivalvular leakage and valve leaflet fatigue.

Devices and methods for the repair of the functioning of heart valves are provided. A device may comprise a ventricular winding having a generally spiral shape, wherein the device is free of any atrial stabilizing section. A method involves positioning the device such that chords associated with the heart valve are positioned within the path of the generally spiral shape of the ventricular winding and turning the ventricular winding such that the chords move closer to the center of the ventricular winding. The ventricular winding draws the chords closer together, thereby pulling the valve leaflets closer together in order to facilitate their coaptation and proper closing. A delivery system for maneuvering and releasing a heart valve repair device comprises an applicator tube and internal rod.

An implant (150) comprises a patch (210), a patch anchor (240), a downstream assembly (300) comprising a winch (320) coupled to a winch anchor (310), and a tether (160) tethering the winch to the patch. A delivery tool (400) has a distal portion that is transluminally advanceable to a heart while the implant is mounted on the delivery tool. The delivery tool has a shaft, a clasp (430), comprising an upstream support and a downstream support, the clasp configured to grasp a portion of a leaflet of a valve of the heart between the upstream support and the downstream support of the clasp, and a driver, configured to anchor the patch to the portion of the leaflet using the patch anchor while the portion of the leaflet remains grasped by the clasp. Other embodiments are also described.

According to the anchoring piece, the restraining device, the conveying system and the conveying method, the anchoring piece adopts an anchoring clamp clamping mode, can adapt to more pathological structures, and can effectively treat aortic valve regurgitation (or aortic valve divalvular and tetravalvular deformity accompanied by aortic valve divalvular and tetravalvular deformity) patients; the protruding anchor is arranged to hang or carry the autologous valve leaflet, valve displacement is prevented, and the perivalvular leakage risk is reduced. The restraining device is provided with a restraining part, the anchoring part is sleeved with a restraining section of the restraining part in an annular shape, a scaling section is connected with the restraining section and arranged in the releasing pipe in a penetrating mode, and the restraining force of the restraining section on the anchoring part is controlled by controlling the scaling section so as to control the releasing speed of the anchoring part. The delivery system optimizes the structure and the function of the whole system, a lumen gap can be properly widened, emptying and water passing are facilitated, the delivery system has better control force when the artificial valve is released due to introduction of the restraining device, and it is guaranteed that when the anchoring piece reaches the lesion position, the anchoring piece is slowly placed, and the aorta and the sinus floor are prevented from being damaged.

Provided is a prosthetic valve replacement system. A hoop member is at least partially disposed on a valve clamping mechanism. A valve clamping and securing mechanism is configured to present a first form and a second form, and the second form is present after the first form. When the valve clamping and securing apparatus is in the first form, the valve clamping mechanism is configured to capture and clamp autologous valve leaflets. After the radial expansion of a valve stent, the valve clamping and securing apparatus is in the second form.

A device and method of inhibiting and preventing damage to leaflets during the crimping of a prosthetic valve, and / or facilitating the folding of the leaflets during the crimping of a prosthetic valve.

A replacement heart valve implant includes an expandable framework including a tubular wall comprising a plurality of interconnected struts and defining a central lumen, wherein the wall includes inflow and outflow ends, and a plurality of commissure posts. A plurality of valve leaflets is secured to the commissure posts. The framework may include a plurality of native leaflet clamps extending upstream from the outflow end, wherein the leaflet clamps are configured to pinch native leaflets of the native heart valve against the wall. The framework may include a plurality of native commissure clamps extending upstream from the commissure posts, wherein the commissure clamps are configured to pinch native commissures of the native heart valve. The framework may include a plurality of native leaflet clamps extending upstream from the commissure posts, wherein the leaflet clamps are configured to pinch native leaflets of the native heart valve against the wall.

Assembly methods for installing a leaflet assembly to an expandable frame of a prosthetic heart valve are described. The leaflet assembly comprises a plurality of leaflets coupled together at adjacent tabs, which form respective commissure tab assemblies. The commissure tab assemblies are inserted into corresponding windows of support members of the expandable frame. One or more wedge members are inserted into the commissure tab assembly, e.g., between the adjacent tabs or with the adjacent tabs therebetween, to restrain radial motion of the commissure tab assembly with respect to the window. The window can be a closed window, and the wedge member insertion can be after the commissure tab assembly is inserted into the window. Alternatively, the window can be an open window or channel, and the wedge member insertion can be before the commissure tab assembly is installed in the window.

The present application provides a valve clamping system, comprising a first clamp piece, a second clamp piece, a catheter, a first actuation element, a second actuation element, and a handle. The first actuation element engages with the first clamp piece and extends proximally through the catheter. The second actuation element engages with the second clamp piece and extends proximally through the catheter. The handle comprises a handle housing connected to a proximal end of the catheter, a first actuation controller and a second actuation controller respectively connected to the first actuation element and the second actuation element, a first linkage member and a second linkage member respectively coupled to the first actuation controller and the second actuation controller, and an unlocking member. The two linkage members cooperate with the unlocking member to achieve both synchronized control and independent control of the first actuation controller and the second actuation controller. The valve clamping system enables synchronous clamping of two valve leaflets of a cardiac valve, ensuring clamping symmetry and consistency in clamping depth, and guaranteeing surgical efficacy.

The invention discloses an expandable artificial biological heart valve and belongs to the technical field of medical instruments, the expandable artificial biological heart valve comprises a valve leaflet, a valve frame and a valve seat, the valve frame is of an annular structure, the valve frame is used for supporting the valve leaflet and fixed to the valve seat, the periphery of the valve frame is wrapped with polyester fabric, the valve leaflet is fixed to the valve frame through a suture line, and the valve leaflet is fixed to the valve seat through the suture line. The outer surface of the valve seat is sleeved with a suture ring, the suture ring is fixedly connected with the valve seat through a suture line, the outer surface of the suture ring is sleeved with a polyester fabric tube, and the valve seat has the elastic deformation capacity so as to adapt to size adjustment in the minimally invasive surgery. The valve seat not only can meet the requirement of minimally invasive surgery, but also meets the requirement of repeated valve implantation possibly needed by young valvular disease patients, the service life of the valve is remarkably prolonged, and the postoperative life quality of the patients is remarkably improved.

The invention relates to a high-molecular artificial heart valve and a preparation method thereof. The high-molecular artificial heart valve is composed of a specially-designed valve support and high-molecular valve leaflets. The inflow end of the valve support extends outwards in the radial direction relative to the outflow end to form a circumference, through holes are distributed in the circumference, a plurality of arc-shaped sections are formed at the outflow end and used for attachment of valve leaflets, reinforcing ribs are arranged on the outer walls of the arc-shaped sections, arc-shaped grooves are formed in the surfaces of the arc-shaped sections, and convex stand columns are arranged at the junctions of the adjacent valve leaflets at the top of the outflow end between the adjacent arc-shaped sections. The preparation method adopts a step-by-step dip-coating curing process and comprises the steps of pre-dip-coating, formal dip-coating and annealing heat treatment. By optimizing the structural design and preparation process of the valve stent, the combination firmness of the valve stent and the high-molecular valve leaflet is remarkably improved, the pore defect between the valve stent and the high-molecular valve leaflet is effectively reduced, and the internal stress of the valve leaflet under the blood flow load is reduced, so that the service life of the high-molecular valve is greatly prolonged; and the reliability and the durability in practical application are improved.

A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.

The valve leaflet screening and matching device comprises a detection box, the detection box is provided with a plurality of movable pulley sets, the movable pulley sets are connected through pull ropes, one end of each pull rope is fixedly connected to the top of a supporting frame, and the other end of each pull rope is connected with a balancing weight; the detection box is provided with a connecting assembly on the movable pulley, and the detection box is provided with a positioning assembly under the movable pulley; an electronic displacement sensing device is arranged at the position, corresponding to the balancing weight, of the detection box, the electronic displacement sensing device can detect the displacement amount of the balancing weight and send detected data to a computer, and the computer uses a screening and matching program to conduct matching of a set of three valve leaflets according to preset screening and matching parameters. The extension length of the valve leaflet when the heavy object is pulled down can be amplified through the pulley block, then the extension length of the valve leaflet is accurately measured, the screening precision is improved, meanwhile, the labor cost is reduced, the subjectivity of manual matching is reduced, and the screening and matching of the valve leaflet are more objective and parameterized.

The utility model relates to the technical field of interventional medical instrument in-vitro simulation demonstration, in particular to a structural heart disease interventional medical instrument in-vitro simulation demonstration device. The device comprises a model fixing device (3), a heart model (31) and a detachable valve leaflet model (32) are fixed on the model fixing device (3), a camera (5) is further arranged on the device, and the device can be used for simulation device demonstration of heart valve intervention medical instrument in-vitro performance research, instrument operation training of an operator in vitro and operation process practice.

The application discloses a heart valve device and relates to the technical field of artificial heart valves, which comprises an outer valve frame and a valve leaflet assembly connected to the inside of the outer valve frame, and the outer valve frame is a ring-shaped grid frame; the outer valve frame comprises an inflow side grid frame and an outflow side grid frame arranged in sequence from an inflow end to an outflow end, and the inflow side grid frame and the outflow side grid frame form an annular recess for clamping a native valve ring on the outer periphery of the outer valve frame; the outflow side grid frame comprises a plurality of groups of grid support units connected in sequence along the circumferential direction and enclosed into a ring, and the grid support unit comprises an outer convex grid support and an inner concave grid support, and the outer surface of the inner concave grid support is arranged in a concave manner relative to the outer surface of the outer convex grid support. In this way, the anterior leaflet of the original mitral valve can be attached to the inner concave grid support, the extrusion of the outer valve frame on the anterior leaflet is reduced, the anterior leaflet is prevented from being extruded to the left ventricular outflow tract by the outer valve frame, and the outflow area of the left ventricular outflow tract is prevented from being reduced to cause obstruction.

Embodiments include a valve leaflet for an implantable valve device comprising a leaflet body. The leaflet body comprising a free edge configured for coaptation with free edges of one or more other valve leaflets; and a root edge disposed opposite the free edge. The free edge defining an edge profile comprising a peak and valleys disposed on opposite sides of the peak. Other embodiments are also included herein.

Disclosed in the present application are an artificial heart valve, an interventional system, and a position registration method for an artificial heart valve. The artificial heart valve comprises: a stent, which is of a cylindrical structure and has a spatially axial direction, the interior of the cylindrical structure being a blood flow channel, and the stent being radially deformable so as to switch between a delivery state in which the stent is radially compressed and a deployed state in which the stent is radially deployed; valve leaflets, which are connected to the stent to control the blood flow channel; and a first radiopaque marker, which is connected to the stent. At the reference angle of viewing of the stent, when the stent rotates around its own axis, the distance between the projection position of the first radiopaque marker and the axis of the stent changes correspondingly.

The invention relates to a valve prosthesis which comprises a stent body and a valve leaflet, the stent body comprises an outflow end and an inflow end, the stent body comprises an inner stent and an outer stent, the inner stent is arranged in the outer stent, the valve leaflet is arranged in the inner stent, and the outflow end comprises a plurality of connecting points. The outer-layer stent and the inner-layer stent are connected with the connecting points after being connected at the outflow end or at the position close to the outflow end, a circle is defined by the multiple connecting points, the circle is provided with a circumference, the circumference is equally divided by the multiple connecting points, on one hand, it can be guaranteed that the outflow end of the stent body is of a symmetrical structure, and the stent body can be evenly compressed into a conveying sheath tube; on the other hand, it can be guaranteed that the stent body is evenly stressed when placed at the lesion position, and therefore the stent body is not prone to falling off.

The application belongs to the technical field of interventional medical instruments, and particularly relates to a valve frame for a pulmonary valve and a pulmonary valve. The valve frame comprises a tubular middle part, a proximal end part and a distal end part connected to the axial two ends of the middle part respectively, the middle part comprises a plurality of grid structures, the distal end part comprises a plurality of unit bodies with an 'M' shape, and the number of the unit bodies is m, m is a natural number greater than or equal to 2. The pulmonary valve comprises a valve leaflet and the valve frame, and the valve leaflet is connected to the valve frame. The valve frame provided by the application can be uniformly expanded, and the overall shape is consistent. The pulmonary valve can be uniformly expanded by adopting the valve frame, and the use requirement that the pulmonary valve can be uniformly expanded is well met, and the use reliability is good.

The invention discloses an intelligent artificial heart valve integrated with pressure sensing, which comprises an implantation end and a body surface relay patch, the implantation end comprises a stent valve main body, a valve crossing pressure sensor pair, a microelectronic module and a flexible circuit, and the stent valve main body comprises a valve frame and a valve leaflet. The transvalvular pressure sensor pair comprises a first pressure sensor fixed to the ventricular proximal side of the stent valve body and a second pressure sensor fixed to the ventricular distal side of the stent valve body, leads of the pressure sensors are electrically connected with the microelectronic module through a flexible circuit, and the flexible circuit comprises a planar spiral coil; the plane spiral coil is electrically connected with the microelectronic module, the body surface relay patch comprises an external read-write coil, the external read-write coil transmits energy to the plane spiral coil, and the cross-lobe pressure sensor sends sensed data to the external read-write coil through the plane spiral coil. According to the invention, abnormal early warning can be realized, the treatment lagging is shortened, and the complication cost is reduced.