21 results about "Papillary muscle" patented technology

A mitral valve prosthesis to be implanted in a heart, comprises an asymmetrical ring, the asymmetrical ring is dimensioned to mimic a native mitral annulus of a patient; an anterior flexible leaflet and a posterior flexible leaflet, said leaflets suspended from the asymmetrical ring and configured to substantially coapt with each other; and at least four sets of cords, each set of cords attached to the anterior or posterior leaflet on a first end and attached into a cap on a second end, the cap is configured to be attached onto papillary muscles of the heart on another end of the cap.

The present disclosure relates generally to the field of medical devices for delivering artificial chordae tendineae in a patient An anchor for engaging a papillary muscle or heart wall is described, wherein the anchor is movable between a delivery configuration and a deployed configuration. When the anchor is in the delivery configuration the anchor has a first outer dimension and when the anchor is in the deployed configuration the anchor has a second outer dimension. The first outer dimension is smaller than the second outer dimension. The anchor is engageable with a papillary muscle or a heart wall when the anchor is in the deployed configuration. The anchor comprises a plurality of arms coupled at a proximal end thereof to a body portion, at least one arm of the plurality of arms movable between a first position and a second position when the anchor moves from the delivery configuration to the deployed configuration. The plurality of arms each have a distal tip for engaging the papillary muscle or heart wall, wherein as the anchor is moved from the delivery configuration to the deployed configuration, the plurality of arms are movable from an elongated shape to a curved shape.

This invention provides an apparatus for repairing heart valves and a method for implanting anchors and repairing heart valves. The apparatus includes: a body; a component attached to the body at a first end and having a plurality of positioning cords extending laterally across a space between the component and away from a second end of the component opposite to the first end; a tube suspended from the plurality of positioning cords; and an adjustment cord extending through the tube. The method includes: implanting at least one annular anchor into the mitral valve annulus of a heart valve; implanting papillary anchors through each papillary muscle of the heart; delivering and positioning the apparatus for repairing the heart valve within the heart valve using at least one annular anchor and papillary anchors; and adjusting the apparatus to adjust the degree of atrial displacement of the mitral valve leaflets during ventricular systole.

The invention discloses a left ventricular papillary muscle target section obtaining method and an ultrasonic evaluation method thereof, and the method comprises the steps: obtaining a standard basic section conforming to a guide, and then determining a corresponding target section and a two-dimensional ultrasonic probe adjustment mode according to the type of a to-be-developed anterior-lateral or posterior-medial papillary muscle and the current standard basic section. The method comprises the following steps: by taking a probe pose when a standard basic section is obtained as a reference, rotating a two-dimensional ultrasonic probe at a specified angle or directionally inclining the two-dimensional ultrasonic probe on the premise of keeping an acoustic window unchanged, so as to obtain an image of a target section which clearly displays a specific long-axis or short-axis form of papillary muscle; the problems of incomplete papillary muscle imaging and form distortion caused by section fixation of conventional two-dimensional ultrasound are solved, the target section can be repeatedly and stably obtained, and completeness and accuracy of papillary muscle ultrasonic imaging are remarkably improved.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

A suture construction for adjustable fixation of a heart valve leaflet relative to a papillary muscle or other supporting heart tissue is defined by a central body portion having a plurality of longitudinally spaced indexing openings or loops, an anchor structure at a first end of the body portion, and a suturing structure at a second end of the body portion. The anchor structure is secured or coupled to the papillary muscle or supporting heart tissue and the suturing structure is passed through the heart valve leaflet where one of the indexing loops is selectively fixed to the heart valve leaflet to adjustably fix the heart valve leaflet in a desired functional position relative to the supporting heart tissue. The indexing loops of the suture construction prevent unwanted movement of the heart valve leaflet in both directions and are securable in very small incremental positions for proper functional spacing.

A method for treating a patient includes delivering a distal portion of an elongate medical device into a ventricle of a beating closed heart of a subject via a primary skin opening and a secondary puncture, utilizing the distal portion of the elongate medical device to engage a plurality of chordae tendineae extending from a first papillary muscle within the ventricle, at least a first one of the plurality of chordae tendineae attached to a first leaflet of an atrioventricular valve located between the ventricle and an adjacent atrium, and at least a second one of the plurality of chordae tendineae attached to a second leaflet of the atrioventricular valve, approximating the engaged plurality of chordae tendineae to increase an amount of closure possible between the first leaflet and the second leaflet, and locking the plurality of chordae tendineae in their approximated condition.

The present disclosure relates generally to the field of medical devices for delivering artificial chordae tendineae in a patient. A system for adjusting tension in an artificial chordae tendineae includes an artificial chordae tendineae coupleable between a clip and an anchor. The clip is engageable with a leaflet of a heart valve while the anchor is engageable with a papillary muscle or heart wall. The anchor includes a body portion, and a locking portion coupleable with the artificial chordae tendineae and configured to allow movement of the artificial chordae tendineae in a first direction while preventing movement of the artificial chordae tendineae in a second direction opposite the first direction. An actuator is coupled to the locking portion for selectively releasing the locking portion to enable selective movement of the artificial chordae tendineae in the second direction.

The present invention provides a method and apparatus for transvascular implantation of newly formed chordae tendineae. [Solution] A method and apparatus for transvascular implantation of artificial chordae tendineae are disclosed. A catheter advances through the mitral valve into the left atrium and left ventricle. A ventricular anchor is deployed from the catheter into the wall of the left ventricle, extending proximal through the catheter, leaving a ventricular suture attached to the anchor. A leaflet anchor is deployed with the leaflet suture extending proximal through the catheter to fix the mitral valve leaflet to the leaflet suture. The leaflet suture is fixed to the ventricular suture to limit the range of movement of the leaflet toward the left atrium. Also disclosed is a mitral valve leaflet restraint assembly that is assembled in its original location, having neopapillary muscle and neochordae tendineae.

The present invention relates generally to the field of medical devices for delivering artificial chordae tendinae in a patient. A system for adjusting tension in an artificial chordae tendinae includes an artificial chordae tendinae couplable between a clip and an anchor. The clip is engageable with a leaflet of a heart valve and the anchor is engageable with a papillary muscle or heart wall. The anchor includes a body portion and a locking portion couplable with the artificial chordae tendinae and configured to allow movement of the artificial chordae tendinae in a first direction while preventing movement of the artificial chordae tendinae in a second direction opposite the first direction. An actuator is coupled to the locking portion to selectively release the locking portion to enable selective movement of the artificial chordae tendinae in the second direction.

A template for a valve construct for replacement of at least one of a mitral valve and a tricuspid valve includes at least an anterior leaflet portion and at least a posterior leaflet portion, each leaflet portion having a proximal edge, a distal edge, and side edges extending between the proximal edge and the distal edge. The template further includes a plurality of substantially straight elongated chordae portions each having a proximal end connected to the distal edge of one of the at least two leaflet portions and a distal end extending therefrom and one or more papillary muscle head portions formed at a commissure between distal ends of at least two of the plurality of chordae portions. A total width of the leaflet portions of the template is substantially equal to a circumference of a native annulus of a heart valve.

A system for transluminal delivery of a heart repair component into a heart includes a visualization catheter having an imaging device disposed at a distal end. An anchoring lumen extends through the visualization catheter to an anchoring port disposed on a distal wall thereof. An adjustment mechanism is translatably disposed within the visualization catheter and configured to adjust a height of the anchoring port relative to a heart septum. The imaging device can be used to visualize placement of an anchor from the port into a tissue target. The adjustment mechanism enables accurate placement of multiple anchors along a consistent axis within the heart by rotating the visualization catheter to align the port with different tissue targets. The anchors can be linked to sutures and the tissue targets can include papillary muscles that are reconfigured by pulling the sutures together and securing to approximate healthy papillary structures.

The invention discloses a method for constructing a survivable fetal left ventricular insufficiency animal model, which comprises the following steps: on the 12.5 day of embryonic development, injecting an all-trans retinoic acid injection into the abdominal cavity of a pregnant mouse, and normally feeding until delivery to obtain the survivable fetal left ventricular insufficiency animal model. The animal model constructed by adopting the method can survive after birth, the ratio N / C of the non-compact layer myocardial thickness to the compact layer myocardial thickness from the part below the left ventricular papillary muscle level to the cardiac apex segment area of a model mouse is greater than 2, the modeling requirement is met, and the problem that the fetal mouse molded by adopting the method in the prior art cannot survive is effectively solved.

Methods and devices for transvascular prosthetic chordae tendinea implantation are disclosed. A catheter is advanced into the left atrium, through the mitral valve, and into the left ventricle. A ventricular anchor is deployed from the catheter and into a wall of the left ventricle, leaving a ventricular suture attached to the ventricular anchor and extending proximally through the catheter. A leaflet anchor is deployed to secure a mitral valve leaflet to a leaflet suture, with the leaflet suture extending proximally through the catheter. The leaflet suture is secured to the ventricular suture to limit a range of travel of the leaflet in the direction of the left atrium. Also disclosed is an assembled in situ mitral valve leaflet restraint, having a neo papillary muscle and a neo chordae tendinea.

The invention discloses a magnetic resonance heart left ventricle automatic segmentation method based on a two-stage active contour model. The method comprises the following steps: (1) image acquisition; (2) image preprocessing: carrying out normalization processing on the image obtained in the step (1) in a range of [0, 255]; (3) image contour initialization: all functions comprise an image binarization function, a connection component marking algorithm and an ROI selection algorithm which are executed by adopting prior information of a left ventricular structure, and a left ventricular region contour is obtained through repeated iteration; (4) two-stage segmentation: segmenting the left ventricle into two stages; the first stage is endocardium segmentation, and the second stage is epicardium segmentation; and (5) post-processing: operating the endocardium segmentation step by adopting a convex interpolation algorithm to obtain the description of the geometric shape of the left ventricle and obtain the papillary muscle at the boundary of the endocardium.

The present disclosure relates generally to the field of medical devices for delivering artificial chordae tendineae in a patient. A system for adjusting tension in an artificial chordae tendineae includes an artificial chordae tendineae coupleable between a clip and an anchor. The clip is engageable with a leaflet of a heart valve while the anchor is engageable with a papillary muscle or heart wall. The anchor includes a body portion, and a locking portion coupleable with the artificial chordae tendineae and configured to allow movement of the artificial chordae tendineae in a first direction while preventing movement of the artificial chordae tendineae in a second direction opposite the first direction. An actuator is coupled to the locking portion for selectively releasing the locking portion to enable selective movement of the artificial chordae tendineae in the second direction.

A suture construction for adjustable fixation of a heart valve leaflet relative to a papillary muscle or other supporting heart tissue is defined by a central body portion having a plurality of longitudinally spaced indexing openings or loops, an anchor structure at a first end of the body portion, and a suturing structure at a second end of the body portion. The anchor structure is secured or coupled to the papillary muscle or supporting heart tissue and the suturing structure is passed through the heart valve leaflet where one of the indexing loops is selectively fixed to the heart valve leaflet to adjustably fix the heart valve leaflet in a desired functional position relative to the supporting heart tissue. The indexing loops of the suture construction prevent unwanted movement of the heart valve leaflet in both directions and are securable in very small incremental positions for proper functional spacing.

The invention discloses an application of a small molecule compound in preparation of a medicine for treating left ventricular densification insufficiency, the small molecule compound is N-(4-chlorphenyl)-5-methyl-N-(4-methyl-4, 5-thiazolidine-2-yl)-3-phenylisoxazole-4-formamide, and the CAS number of the small molecule compound is 878090-53-0. A left ventricular non-compact layer of a newborn mouse intervened by the small molecule compound is obviously thinned, a compact layer is obviously thickened, and the N / C ratio of the nipple muscle level and the cardiac apex segment is from gt of the model group; 2.5 is obviously reduced to 1t; 0.8, the small molecule compound basically recovers to a normal control level, that is, the small molecule compound has a relatively good prevention and / or treatment effect on left ventricular insufficiency.

A device configured to be positioned within a native heart valve to repair the valve. The device includes a leaflet pinching or capturing mechanism to capture a first leaflet and second leaflet of the native valve and then attach the first leaflet to the second leaflet. The device includes a first surface and a second surface, wherein the first surface and the second surface are movable between an open condition and a closed condition to pinch a first leaflet and a second leaflet of the native valve therebetween. Once the first and second leaflets are captured, portions of the leaflets are fused together, adhered together, or fused and adhered together. In some implementations, a system is configured to access a papillary muscle and ablate tissue of the papillary muscle to disable a conductive pathway to the papillary muscle.

An implant system and delivery method includes a catheter system including a sling catheter having a plurality of distal openings and a delivery catheter disposed within the sling catheter and having a distal port. Suture-linked anchors can be sequentially delivered by the delivery catheter to a cardiac treatment site to embed the anchors in cardiac tissue, such as papillary muscle tissue, by aligning the port of the delivery catheter with a different opening of the sling catheter and pushing an anchor through the port and the sling catheter. Each anchor can have a linear configuration for translation within the delivery catheter and a biased configuration that resists re-entry into the sling catheter once deployed. Once all anchors are deployed, the sutures can be tightened, the anchoring portion of the sling catheter can be detached, and the catheter system can be withdrawn.