148 results about "Tricuspid valve" patented technology

Apparatuses, systems, and methods for various devices, such as prosthetic valves. Some examples are directed to improvements in anchoring at a native heart valve, which may reduce possible trauma to a treatment or implantation site. Compliant and flexible anchoring features and methods are disclosed to reduce force upon a treatment or implantation site including heart tissue that surrounds leaflets of a mitral or tricuspid valve. Improved mechanisms for deployment of devices including motorized methods are also disclosed.

The invention discloses a method for noninvasive diagnosis of pulmonary arterial hypertension and a related device, and relates to the technical field of artery detection.The method comprises the steps that an echocardiogram result and right heart catheter pulmonary artery pressure data of a suspected pulmonary artery patient are obtained; the echocardiogram result is a tricuspid regurgitation spectrum; grading the quality of the tricuspid regurgitation spectrum based on a TR spectrum quality grading standard according to the regurgitation spectrum missing degree of the tricuspid regurgitation spectrum; according to the echocardiogram result and the right heart duct pulmonary artery pressure data, on the basis of the quality grading result of the tricuspid regurgitation spectrum, a personalized pulmonary artery hypertension diagnosis model suitable for different patients is constructed; according to the pulmonary arterial hypertension diagnosis model, on the basis of the echocardiogram result of the target pulmonary arterial patient, a pulmonary arterial hypertension diagnosis result of the target pulmonary arterial patient is obtained, and personalized accurate diagnosis can be carried out on different pulmonary arterial hypertension patients under the noninvasive condition.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

The invention relates to a real-time wear test device for a cardiovascular implant mitral valve / tricuspid valve, which comprises a plurality of test mechanisms, and each test mechanism comprises a first compliance adjusting module, a second compliance adjusting module, a liquid flowing pipeline and a driving module, a valve carrier module and a return pipe are connected between the second compliance adjusting module and the first compliance adjusting module; one end of the liquid flowing pipeline is communicated with the first compliance adjusting module, and the other end is connected with the driving module; test liquid sequentially flows through the liquid flowing pipeline, the first compliance adjusting module, the backflow pipe, the second compliance adjusting module and the valve carrier module and flows back into the first compliance adjusting module and the liquid flowing pipeline so as to perform circulating reciprocating motion. According to the invention, a test environment highly similar to human physiological conditions can be simulated, so that the credibility and the accuracy of test results of the mitral valve and the tricuspid valve are ensured, and a real and reliable basis is provided for evaluating the service life of the mitral valve and the tricuspid valve.

Disclosed are devices, systems, and methods for in vivo monitoring of biological fluid flow within anatomical structures, such as blood flow through heart valves (e.g., mitral, tricuspid, and / or aortic valves) or heart chambers. The disclosed devices, systems, and methods can continuously measure and evaluate blood flow back and forth at the inlet of a heart valve to determine cardiac function or dysfunction and / or to compile with other monitored data that can be used to measure or predict secondary factors.

Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to the anatomy at the site of the native heart valve. Such structural features can provide robust migration resistance. In addition, the prosthetic heart valves can include structural features that improve sealing between the prosthetic valve and native valve anatomy to mitigate paravalvular leakage. In particular implementations, the prosthetic heart valves occupy a small delivery profile, thereby facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems can include a curved inner catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.

The invention relates to a heart valve regurgitation drum and optional closure disk and / or tubular stent to manage and provide levels of intentional regurgitation within an orthogonally delivered transcatheter prosthetic heart valve having a first inner flow control component / valve, a second inner regurgitation control component, and an outer annular support frame having compressible wire cells that facilitate folding flat along the z-axis and compressing the valve vertically along the y-axis, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

The invention relates to an anchor hook and methods of using the same for subannular anchoring of a transcatheter heart valve replacement, and in particular for an orthogonally delivered (side-delivered) transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the mitral or tricuspid valve from the inferior vena cava or superior vena cava, or trans-septally to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring a delivery catheter to bend 90 degrees during deployment.

A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.

The invention relates to anchor channels and subannular anchors for a transcatheter heart valve replacement, and in particular for an orthogonally delivered transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

A tricuspid regurgitation treatment tool to be inserted into the pulmonary artery is proposed. The tricuspid regurgitation treatment tool to be inserted into the pulmonary artery is used to verify whether the right ventricular dysfunction may occur when treating the tricuspid regurgitation by surgeries or other permanent treatments. A test insertion of the tricuspid regurgitation treatment tool to be inserted into the pulmonary artery is made to pass obliquely through the tricuspid valve of a patient, and after a certain time has elapsed, the tool is removed. The tricuspid regurgitation treatment tool to be inserted into the pulmonary artery includes: a blocking part blocking the tricuspid valve; and an insertion tube provided with a guidewire-guiding lumen formed therein to be movable along the guidewire.

Medical delivery system for accessing a tricuspid valve via an inferior vena cava, including an outer guide catheter, an inner guide catheter and an interventional catheter. The first deflection portion of the outer guide catheter is steerable to define a first outer-guide-catheter curve and the second deflection portion of the outer guide catheter is steerable to define a second outer-guide-catheter curve and the first deflection portion of the inner guide catheter is steerable to define a first inner-guide-catheter curve.

A stabilizer sleeve is disclosed for use with cardiac implantable electronic device leads. The sleeve comprises a tubular body sized to receive the lead and shaped to bias the lead toward a desired anatomical location, thereby reducing migration, dislodgement, and interference with cardiac structures. The sleeve may be introduced with the lead as a unitary assembly or added after lead placement. Various embodiments include a slitted body for expansion, radiopaque markers for visualization, detachable nose-cone tips for guidewire tracking, and antimicrobial coatings. The sleeve may be formed of polymers, alloys, or composite materials, and may include features such as texturing or anchoring projections for tissue engagement. Applications include positioning within a tricuspid valve commissure to minimize regurgitation and stabilizing left ventricular leads within branches of the coronary sinus. The device and methods described provide improved long-term stability and performance of implanted cardiac leads.

The present invention relates to an artificial heart valve, which comprises a valve stent, a first sealing membrane, a second sealing membrane, valve leaflets and valve leaflet anchoring members. The valve stent includes an inflow section and an outflow section; the first sealing membrane is attached to the outer side of the valve stent and comprises a hydrophilic swelling material, which can absorb liquid and swell after contacting with blood, for reducing paravalvular leakage; the second sealing membrane is arranged on the outer side of the first sealing membrane and at least covers all regions corresponding to the outer surface of the inflow section, for increasing the friction with the native valve leaflets; the valve leaflets are arranged inside the valve stent for controlling the unidirectional flow of blood; the valve leaflet anchoring members are spiral and can be coiled outside the mitral / tricuspid chordae tendineae plexus and interact with the valve stent. By providing the first sealing membrane and the second sealing membrane, the artificial heart valve of the present invention can better fit with the native tissue after being implanted into the mitral / tricuspid valve, so as to effectively prevent the occurrence of paravalvular leakage.

The present invention discloses devices and methods for treating or repairing regurgitant heart valves such as the mitral valve and / or the tricuspid valve. Exemplary valvuloplasty devices can be placed in the coronary sinus to re-shape the mitral valve and reduce mitral regurgitation as well as tricuspid regurgitation. The present disclosure also provides improved techniques for cardiac pacing.

Apparatus and methods for repairing a cardiac valve, e.g., a tricuspid valve, are provided. The apparatus may include a prosthetic device coupled to an elongated support coupled to a stent configured to be implanted within a vessel, e.g., the superior vena cava, to suspend and maintain the prosthetic device within the cardiac valve. The support may include a proximal, delivery portion detachably coupled, in a delivery state, to a distal, implantable portion coupled to the prosthetic device. The prosthetic device may be formed of biocompatible material coupled to a frame, and may have prosthetic leaflets that allows blood to flow therethrough in one direction during diastole, but prevents blood regurgitation during systole. The stent further may include features configured to resist migration of the stent within the vessel, as well as to prevent in-folding of the stent during deployment.

A traditional Chinese medicine formula for treating blood vessel clogging belongs to the field of traditional Chinese medicine formulas, and comprises the following main raw materials: 29-31 parts of black pearl, 11-13 parts of codonopsis pilosula, 7-9 parts of saffron crocus, 8-10 parts of angelica sinensis, 190-210 parts of leek, 9-11 parts of pseudo-ginseng, 37-43 parts of hawthorn, 95-105 parts of astragalus membranaceus, 18-22 parts of kudzu vine root, 8-10 parts of peach kernel, 8-10 parts of prepared rehmannia root, 9-11 parts of radix rehmanniae, 11-13 parts of white paeony root, 3 parts of red ginseng, 9-11 parts of radix ophiopogonis, 14-16 parts of spina date seed, 11-13 parts of Chinese yam, 14-15 parts of schisandra chinensis, 9-11 parts of polygonum multiflorum, 7-9 parts of cinnamon, 18-21 , 13-15 parts of anise and 12-14 parts of rhizoma polygonati. The traditional Chinese medicine composition has an obvious improvement effect on coronary artery insufficiency, myocardial ischemia, mitral valve, tricuspid valve, aortic valve regurgitation, chronic heart failure, patients needing operation bypass stenting, angina pectoris, myocardial infarction sequelae, cerebral ischemia, cerebrovascular sequelae and other symptoms caused by cardiac insufficiency, the dosage is small, the effect is fast, the cure rate is high, relapse is not prone to occurring, and the traditional Chinese medicine composition is suitable for clinical application. The effects of tonifying qi and activating blood, dredging channels and relieving pain, eliminating phlegm and removing blood stasis, tonifying heart and soothing nerves and the like can be achieved.

The present invention discloses a device for repairing tricuspid regurgitation by accordion chordae tendineae, comprising: a chord-gathering member for wrapping around and accordion-gathering the chordae tendineae; a fixing member connected to the chord-gathering member for positioning the device for repairing tricuspid regurgitation by accordion chordae tendineae; and a counterweight block at the connection between the chord-gathering member and the fixing member for stabilizing the chord-gathering member. The present invention effectively prevents the device for repairing tricuspid regurgitation by accordion chordae tendineae from moving upward by adding a counterweight block between the accordion-gathering hollow rod of the chord-gathering member and the fixing member. The position of the counterweight block can be adjusted to adjust the center of gravity of the device for repairing tricuspid regurgitation by accordion chordae tendineae, further stabilizing the device and improving its fit with the heart, such as the atrial wall. Furthermore, the counterweight block is connected to the accordion-gathering hollow rod and the fixing hollow rod via threads, allowing the position of the counterweight block to be adjusted in advance according to the patient's heart shape.

Prosthetic heart valves may be delivered to a targeted native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valves are implanted using catheter-based deployment systems that include multiple control wires. In particular implementations, the deployment systems can include a retrieval catheter that can be used to recapture the prosthetic heart valve back into a delivery sheath after being expressed from the delivery sheath. The prosthetic heart valves can include a plurality of optional suture knots to enhance migration resistance. Some delivery catheter systems can include a controllably bendable control catheter and / or a deflectable catheter to facilitate deployment of the prosthetic heart valve to a native tricuspid valve site via a superior vena cava or inferior vena cava.

The invention relates to constriction devices and methods for deploying a laterally delivered prosthetic heart valve in a native annulus. The present invention relates to anchoring channels and subannulus anchors for transcatheter heart valve replacement (A61F2 / 2412), and in particular for transcatheter prosthetic heart valves with orthogonal delivery of an annulus support frame having a compressible wire unit, the compressible wire unit facilitates rolling and folding of the valve in a longitudinal direction or orthogonal to a central axis of the flow control member, allowing delivery and deployment of a very large diameter valve from the inferior vena cava or superior vena cava to the tricuspid valve, or trans-atrial delivery and deployment to the mitral valve, or delivery and deployment of a very large diameter valve from the inferior vena cava or superior vena cava to the tricuspid valve. The valve has a height of about 5 mm to 60 mm and a diameter of about 25 mm to 80 mm without the need for an over-diameter catheter and without the need for delivery and deployment from the catheter at an acute access angle.

An annuloplasty ring for attachment to an annulus of a tricuspid valve comprises an elongate tube of suturable material comprising a central segment and first and second end segments. An arcuate stiffener is received in the central segment of the tube and extends the length thereof. The arcuate stiffener is circumferentially confined within the central segment to prevent circumferential movement of the stiffener relative to the tube. The first and second end segments of the tube lack a stiffener and are axially deformable.

The invention relates to anchor channels and subannular anchors for a transcatheter heart valve replacement, and in particular for an orthogonally delivered transcatheter prosthetic heart valve having a annular support frame having compressible wire cells that facilitate rolling and folding the valve length-wise, or orthogonally to the central axis of the flow control component, allowing a very large diameter valve to be delivered and deployed to the tricuspid valve from the inferior vena cava or superior vena cava, or trans-atrially to the mitral valve, the valve having a height of about 5-60 mm and a diameter of about 25-80 mm, without requiring an oversized diameter catheter and without requiring delivery and deployment from a catheter at an acute angle of approach.

The invention belongs to the technical field of medical treatment, particularly discloses an application of allicin in preparation of a medicine for improving right heart dysfunction caused by pulmonary arterial hypertension, and discloses an effect of the allicin in treatment of the right heart dysfunction caused by the pulmonary arterial hypertension. Compared with existing medicines (mainly for reducing pulmonary arterial pressure) for treating pulmonary arterial hypertension, allicin not only can reduce the pulmonary arterial pressure and relieve the symptoms of pulmonary arterial hypertension, but also can remarkably improve right heart dysfunction caused by pulmonary arterial hypertension, and the allicin is specifically shown as follows: (a) average pulmonary arterial pressure, pulmonary artery ejection time and pulmonary artery end diastolic inner diameter are reduced; the pulmonary artery acceleration time is prolonged; (b) the right ventricular systolic pressure, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic free wall thickness, the right ventricular end-of-systolic inner diameter and the right heart hypertrophy index are reduced, and tricuspid valve displacement, stroke output and right heart discharge are increased; and (c) improving right ventricular and pulmonary vascular remodeling.

The present invention discloses a shock wave balloon dilation catheter comprising a balloon and a dilation catheter. The balloon includes a blood flow passage on its outer circumference and / or interior, extending axially and penetrating through the outer circumference and / or center. A shock wave generator is arranged within the balloon chamber, where conductive fluid can be introduced. The distal end of the dilation catheter passes through or into the balloon and is sealedly connected to the balloon. A fluid passage in the catheter communicates with the balloon chamber, and the shock wave generator is fixed to the portion of the catheter within the balloon. The dilation catheter is provided with a guide wire lumen. The present invention further discloses a shock wave balloon dilation catheter for tricuspid valve openings, which designed to avoid blood flow blockage and reduce the hemodynamic impact during the procedure, enhancing safety and treatment effectiveness.

The present invention relates to an anchoring channel and a subannular anchor for transcatheter heart valve replacement (A61F2 / 2412), and in particular for an orthogonally delivered transcatheter prosthetic heart valve having an annular support frame having a compressible wire unit that facilitates rolling and folding of the valve longitudinally or orthogonally to the central axis of the flow control component, thereby allowing very large diameter valves to be delivered and deployed from the inferior vena cava or superior vena cava to the tricuspid valve, or delivered and deployed transatrially to the mitral valve, the valve having a height of approximately 5 mm-60 mm and a diameter of approximately 25 mm-80 mm, without the need for an overly large diameter catheter and without the need for delivery and deployment from the catheter at an acute approach angle.

The invention relates to the technical field of medical instruments, in particular to an artificial valve implanting system for bicuspid and tricuspid valves, which comprises an annular fixing device and an artificial valve, the annular fixing device is sleeved on the inner periphery and the outer periphery of the artificial valve, the artificial valve comprises a valve frame, and the valve frame comprises an upper valve frame part and a lower valve frame part. The upper valve frame part and the lower valve frame part are in sliding connection and are used for height adjustment; an upper anchoring claw and a lower anchoring claw are arranged on the valve frame and used for grabbing the upper inner edge and the lower inner edge of the annular fixing device respectively. The design is ingenious, the upper valve frame part and the lower valve frame part are in sliding connection and can be used for adjusting the height of the artificial valve, the height of the valve frame at the ventricle position can be adjusted, the use flexibility is improved, the risk of left ventricular outflow tract obstruction can be effectively reduced, the annular fixing device is arranged on the outer periphery and the inner periphery of the artificial valve in a sleeving mode, and the artificial valve is more stable. The inner and outer double-layer combined ring ensures that the artificial valve is not easy to displace, stable in structure and high in reliability.

The prosthetic heart valve may be delivered to a target native heart valve site via one or more delivery catheters. In some embodiments, the prosthetic heart valve includes structural features that securely anchor the prosthetic heart valve to an anatomical structure at a native heart valve site. Such structural features may provide robust resistance to migration. In addition, the prosthetic heart valve may include structural features that improve sealing between the prosthetic valve and native valve anatomy to mitigate perivalvular leakage. In particular embodiments, the prosthetic heart valve occupies a small delivery profile, facilitating a smaller delivery catheter system for advancement to the heart. Some delivery catheter systems may include a curved inner catheter to facilitate deployment of the prosthetic heart valve to the native tricuspid valve site via either the superior vena cava or the inferior vena cava.

Medical delivery system for accessing a tricuspid valve via an inferior vena cava, including an outer guide catheter, an inner guide catheter and an interventional catheter. The first deflection portion of the outer guide catheter is steerable to define a first outer- guide-catheter curve and the second deflection portion of the outer guide catheter is steerable to define a second outer-guide-catheter curve and the first deflection portion of the inner guide catheter is steerable to define a first inner-guide-catheter curve.

A surgical suturing device is disclosed. The surgical suturing device may include a first or a second tissue gap, a first pair of needles configured to be movable across the first tissue gap, a second pair of needles configured to be movable across the second tissue gap, and a first suture having first and second ends. The surgical suturing device also includes a second suture having first and second ends and a needle actuator which selectively engages either: the first pair of needles to drive them through the first tissue gap and into communication with the first end of the first suture and the first end of the second suture, respectively; or the second pair of needles to drive them through the second tissue gap and into communication with the second end of the first suture and the second end of the second suture.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.