75 results about "Interventricular septum" patented technology

A cardiac stimulation system and method delivers a left ventricle stimulator from a right ventricle lead system in the right ventricle chamber, into a right side of an interventricular septum at a first location, and transmuscularly from the first location to a second location along the left side of the septum. The left ventricle stimulator is affixed at the second location for transmuscular stimulation of the left ventricle conduction system. A biventricular stimulation system further includes a right ventricle stimulator also delivered by the right ventricle lead system to the first location along the right side of the septum for right ventricular stimulation. An energy source is coupled to the transmuscular stimulation system, i.e., a pacemaker, and/or defibrillator, or to enhance contractility, and may be coupled directly or via “leadless” system(s). Various highly beneficial particular arrangements of stimulators and leads are further described.

Methods and systems for monitoring a heart failure or transplant rejection status of a patient including use of a device or system to collect intramyocardial electrogram (IMEG) signals from the patient at different times automatically when a detected activity level of the patient is below a preset threshold level for a predetermined amount of time, and use of a device or system to generate a status indicator value proportional to a combination of parameters extracted from at least a portion of the collected IMEG signals. Methods and systems can also include measuring time delay values between IMEG signals collected from different locations in the patient. The IMEG signals can be collected from the right ventricular septum and the right ventricular apex of the patient or from the right and left ventricular myocardium of the patient.

Anchor assemblies for endovascular introduction and implantation for tethering a replacement heart valve to a cardiac wall. An anchor delivery system introduces the assembly. The anchor may be either implanted with a tether connected thereto or implanted and then connected to a tether. If the latter, a tether assembly is mounted to the implanted anchor to connect the anchor to the valve. The anchors may be implanted into any cardiac wall including the interventricular septum or the epicardial space and the valve may replace the mitral or tricuspid valve.

The invention provides a novel degradable stopper implanted through a guide pipe. The novel degradable stopper comprises a ball bag, a supporting rod and degrading liquid. The supporting rod is fixedly connected with the ball bag, the periphery of the supporting rod is wrapped by the ball bag, and the degrading liquid is a biological material which can be degraded and absorbed and is arranged in the ball bag in a filling mode to play a supporting effect. The invention further provides a conveying system of the novel degradable stopper implanted through the guide pipe. The conveying system comprises a long sheath, an inner core, a loader, a pushing rod and an infusion pipe. The stopper is made of degradable materials, foreign objects are not left in vivo, and a long-term effect is obvious. In addition, the stopper is of a ball bag type structure, and the inner filler of the stopper is temperature-sensitive hydrogel. When an abnormal defect is blocked, the stopper can be attached to the periphery of the defect completely, and especially a better blocking effect is achieved on irregular defects. The stopper can be suitable for blocking of the patent ductus arteriosus and can be made into a stopper suitable for atrial septal defects and a stopper suitable for ventricular septal defects through changing of the shape of the ball bag.

The invention discloses a transthoracic minimally invasive occlusion interventricular septum defection plugger conveying appliance. The invention is characterized in that the device comprises a locating line, a conveying passage and a cardiac plugger adaptor; one end of the conveying passage is lead to the invasive occlusion part of the interventricular septum guided by the locating line, the cardiac plugger is installed inside the plugger adaptor, after being butted with the conveying passage, the cardiac plugger adaptor enters the position of the interventricular septum defection through the conveying passage and begins to work at the position. The conveying is mainly characterized in that the entire device is short and small, and can be held by hands directly. The defection part can be closed as near as possible, and puncture, direction adjusting, guide rail building, and plugger releasing can be finished by only one person, during the operation, once the septum defection is not suitable for the method or the plugging fails, the incision can be directly extended upward and changed into the traditional thoracotomy, no extra incision is needed, or transferred from the cardiac catheter room to the operating room, and the security of the patient is greatly ensured.

A blocking device for both muscular and membranous ventricular septal defects features that it has the extended parts of discoid like the butterfly's wings and the space between the said butterfly wings. As a result, it can not damage the important organs such as aortic valve near the defect after it is transplanted in human body. Its preparing process includes such steps as carving slits on NiTitube to form netted tube, vacuum heat treating for high elasticity, removing oxidized film from its surface, welding netted tube to jointer, putting in a mould, high-temp. shaping, cooling, and demoulding.

The invention relates to a mitral valve replacement system for a percutaneous transcatheter, and belongs to the technical field of medical instruments. The mitral valve replacement system comprises avalve frame supporting body, an artificial valve leaflet and a ventricular septum anchoring structure. The valve frame supporting body is arranged between an atrium and a ventricle and provided with ahollow cavity with the two ends open. The artificial valve leaflet is arranged on the inner wall of the cavity of the valve frame supporting body. The ventricular septum anchoring structure is arranged between the valve frame supporting body and a ventricular septum. The invention provides the mitral valve replacement device intervened through a catheter via a femoral vein admission passage and aims to solve the problems that an existing interventional mitral valve system is generally large in valve stent, has the left ventricular outflow passage obstruction risk, has potential complicationsin transapical admission passage and anchoring and the like, and the mitral valve replacement device provided by the invention is more minimally invasive and firmer in anchoring, and the technical scheme of mitral valve replacement suffering from left ventricular outflow tract obstruction can be effectively avoided.

The present invention discloses a puncture needle system and a method for transcatheter ventricular septal puncture. The puncture needle system comprises a puncture needle made of nickel-titanium memory alloy and a hollow tubular puncture sheath, and the puncture needle comprises a tip part and a tail part; an operating handle is connected with a tail part of the puncture needle, a tip part of thepuncture needle is preset to be smoothly bent, so that when a temperature of the puncture needle is higher than a phase change temperature of the puncture needle, the tip part of the puncture needleis smoothly bent along with increased hardness, when the temperature of the puncture needle is lower than the phase change temperature of the puncture needle, the puncture needle is soft with decreased hardness; and the puncture sheath is used for the puncture needle to freely penetrate through and bent in a corresponding shape at a position of the puncture sheath corresponding to the tip part ofthe puncture needle. The puncture needle made of the nickel-titanium memory alloy is used, and when the temperature of the puncture needle is higher than the phase change temperature, the puncture needle automatically changes the hardness and bending angles of the tip part and is thus convenient for the ventricular septal puncture.

The invention relates to a puncture needle component which comprises a puncture needle, a navigation guide wire, a sheathing tube with a dilator and a three-dimensional positioning and orienting device. The navigation guide wire is arranged inside the puncture needle to form an integrated guide-wire-shaped solid core puncture needle which is connected with the sheathing tube and the three-dimensional positioning and orienting device. The puncture needle component can be used for completing interventricular septum puncture and interatrial septum puncture through a venipuncture approach, the problems of the prior art can be solved effectively, unlimited selecting of surrounding blood vessel approaches of a pre-operation position can be realized, spatial position selecting of a puncture target can be limited effectively while moving direction of a needle tip of the puncture needle can be positioned accurately and objectively, and two steps of puncture spacing of the puncture needle and building of a guide wire rail can be completed in one step; the puncture needle component is safe, simple and convenient to operate, operating technical difficulty is lowered substantially, operating technical error risk is avoided completely, and risks such as perforation of free ventricular wall and cardiac tamponade are avoided fully.

The invention relates to the field of medical instruments, in particular to a hypertrophic myocardium ablation system. Existing minimally invasive radio frequency ablation has various problems of difficulty in control of ablation range and depth, limited curative effect and the like. The invention provides a hypertrophic myocardial ablation system which comprises an ablation device and a console. The ablation device comprises a catheter, a handle and ablation electrodes; two ablation electrodes are provided and arranged in the far end of the catheter; the two ablation electrodes are respectively arranged at the ends of two electrode catheters; the two electrode catheters are hollow and penetrate through the catheter; a driving mechanism is arranged on the handle and can drive the electrode catheters to move, so that the ablation electrodes can stretch out of the far end of the catheter; the front portions of the two ablation electrodes are of a spiral shape; the front ends of the spiral shapes are tips; the spiral radius of the spiral shapes is gradually reduced from back to front; and the driving mechanism can drive the two ablation electrodes to carry out telescopic translation and rotating motion relative to the catheter. According to the invention, the pulse electric field energy can be deeply transferred into hypertrophy ventricular septal tissues to form partial and irreversible myocardial necrosis, and vascular nervous tissues cannot be affected.

The invention discloses application of a cardiac magnetic resonance imaging (MRI) examination technology. The cardiac magnetic resonance imaging technology includes an electrocardiographic synchronization technology and a respiratory synchronization technology; the selection of cardiac magnetic resonance scanning layers includes cross-sectional imaging, coronal plane imaging, vertical plane imaging, a left ventricle long axis position, left anterior oblique position and left ventricle short axis position parallel to the ventricular septum, and a left ventricle long axis and four-chamber heartposition perpendicular to the ventricular septum; and a cardiac vessel scanning sequence includes magnetic resonance cardiac cine imaging, helical scanning and cardiac examination impulse sequence. The MRI examination technology has the advantages of comprehensively providing the guidance use flows of MR model Siemens Aera1.5T and cardiac MR model GE750w, and being simple and easy to understand.

The invention relates to a method for non-invasive measurement of right ventricular pressure and pulmonary artery pressure method. The method comprises the following steps of obtaining a bicuspid valve horizontal left ventricle short-axis two-dimensional ultrasonic image; drawing points and interventricular septum, a fitting curve of an arc-shaped interventricular septum is formed, the curvature radius and an arc length of the fitting curve are worked out; on the basis of the tubular hypothesis formula of the laplace's theorem, and the left and right ventricle wall pressure is obtained through calculation. Accordingly, non-invasive measurement, ventricular pressure monitoring and pulmonary artery pressure monitoring can be achieved by researching the ventricular wall curvature changes of left and right ventricles.

The invention discloses a novel double-layer occluder which includes an occluder body. A fixer is arranged at the upper end of the occluder body, and a connector is arranged at the lower end of the occluder body. The occluder body is connected to an external conveying steel cable through the connector, the occluder body includes an outer layer and an inner layer which are composed of metal wires,one of the ends of the metal wires of the inner layer and the outer layer are respectively fixed to the fixer, and the other of the ends of the metal wires of the inner layer and the outer layer are respectively fixed to the connector. The novel double-layer occluder has the advantages of good stability, high anatomical adaptability, not prone to hemolysis, and low valve influence, and the closureof paravalvular leak, patent ductus arteriosus and ventricular septal defect by a transcatheter intervention method is completed; the radial support force is high; the instrument structure is compact, red blood cells are not prone to passing, and occluder-related hemolysis is not prone to causing; after the instrument is deformed and fixed, residual parts on and below the paravalvular leak are few, the device is not close to an artificial valve, and the opening and closing of the artificial valve are not prone to influencing; and the damage to an approach blood vessel is small, and blood vessel complications are fewer.

A guidewire may be configured for insertion into a heart of a patient during a procedure such as a transcatheter aortic valve replacement procedure. The guidewire may include a proximal end and a distal end portion. The distal end portion may include (i) a leading section, (ii) a loop structure at a terminal distal end of the guidewire, and (iii) a transition section extending between the leading section and the loop structure. In the absence of applied forces, the leading section is not tangential to the loop structure. With such a configuration, the guidewire may avoid contact with the ventricular septum of the heart when the loop structure is seated within the left ventricle, which may mitigate potential interference with conduction pathways in the ventricular septum, which may in turn mitigate the need for a pacemaker.

The invention belongs to the technical field of new applications of medicines and particularly discloses application of an exogenous Cyclo(-RGDfK) polypeptide to preparation of medicines for preventing and treating hypertensive pulmonary arterial disease. The applicant discovers that the exogenous Cyclo(-RGDfK) polypeptide is capable of controlling activity of Rac1 and RhoA in lung tissues of pulmonary hypertension model rats so as to inhibit proliferation of pulmonary artery smooth muscle cells of wild pulmonary hypertension model rats. The therapeutic study results show that the exogenous RGD polypeptide has therapeutic effects of obviously inhibiting proliferation of pulmonary artery smooth muscle cells, reducing the right ventricle systolic pressure and reducing the ratio of the weightof the right ventricle to the total weight of the left ventricle and the interventricular septum. The invention firstly discloses application of the exogenous Cyclo(-RGDfK) polypeptide to treatment of the hypertensive pulmonary arterial disease and provides the medicine basis for treating the hypertensive pulmonary arterial disease.

The present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect, and more particularly, to a RF ablation catheter for septal reduction therapy that is for performing RF ablation, in which RF energy is applied to an interventricular septum, for septal reduction therapy such as therapy for hypertrophic cardiomyopathy, which is a disease in which an interventricular septum of the left ventricle of the heart of the animal or human body thickens, therapy that requires reduction of an interventricular septum, or therapy for ventricular tachycardia. Also, the present disclosure relates to a RF ablation catheter for septal reduction therapy having a cooling effect that is for preventing carbonization of a tissue of the body (interventricular septum) around an electrode.

An exemplary embodiment of the present disclosure provides a RF catheter for septal reduction therapy, the RF catheter including: an intra-septal part in which a tapered tip which becomes thinner toward an end thereof is formed at an end of a distal part and one or more electrodes are formed at positions on an outer circumferential surface that are adjacent to the tip; and a body part which is made of a soft material and has a guidewire lumen which passes through the intra-septal part from an inlet formed at the center of the end of the tip and has an outlet formed in a side surface, a coolant inlet lumen which is connected from a proximal part to an inner portion of the intra-septal part to allow a coolant to be injected from the outside and which has an open end, and a coolant outlet lumen which communicates with the coolant inlet lumen and has an exit formed in a side surface, wherein the guidewire lumen and the coolant inlet lumen do not communicate with each other and are partitioned from each other.

The present disclosure relates to a device for valve regurgitation surgery and pacemaker lead fixation, and more particularly, to a device for valve regurgitation surgery and pacemaker lead fixation that allows mitral regurgitation surgery, tricuspid regurgitation surgery, and fixation of a pacemaker lead to an interventricular septum to be performed using a single device. The device for valve regurgitation surgery and pacemaker lead fixation according to the present disclosure includes a cerclage wire, a coronary sinus tube which has a lumen formed to insert the cerclage wire thereinto and which is inserted into a coronary sinus, a tricuspid valve tube which has a lumen formed to insert the cerclage wire thereinto and which crosses a tricuspid valve and protects tissues of the tricuspid valve and the interventricular septum, a lead insertion tube which is coupled to the tricuspid valve tube and has an end facing the interventricular septum, and a pacemaker lead which is inserted into the lead insertion tube and has an end inserted into the bundle of His.

The invention discloses a leadless pacing system for achieving left bundle branch pacing on the left ventricle side of an interventricular space, and relates to the field of surgical instruments. Thesystem includes: a pulse generator; and a delivery system for delivering the pulse generator to cause the pulse generator to screw into the myocardium and contact the left branch.