31 results about "Interventricular septum" patented technology

The invention relates to a simulation-based target removal area determination method and device. The method comprises the following steps: acquiring a heart simulation model and corresponding blood flow field information; according to the left heart lumen model and the blood flow field information, determining a first target area in the ventricular septum model; stress calculation is carried out according to the ventricular septum model, and a second target area in the ventricular septum model is determined; determining an initial target area according to the first target area and the second target area; according to the ventricular septum model, determining the thickness range of the initial target area at the end of contraction; determining a target cutting thickness according to a preset basic thickness and a thickness range; according to the heart simulation model, the initial target area, the target resection thickness and the blood flow field information, a first target resection area is determined. By adopting the method, the cardiac muscle tissue area needing to be cut off can be accurately determined.

This invention discloses a method for preparing a simulated heart model and the simulated heart model itself. The method for preparing the simulated heart model includes: dividing a digital heart model into two parts along its coronal plane; preparing corresponding molding molds according to the structural characteristics of the two parts, each molding mold including an outer molding mold and an inner cavity molding mold; applying silicone to the molding surfaces of the outer molding mold and the inner cavity molding mold to form the endocardium and epicardium; applying silicone to the portion of the inner cavity molding mold used for molding the valve to form the valve; assembling the outer molding mold and the inner cavity molding mold to form a cavity; sequentially injecting silicone of corresponding hardness into the regions of the cavity used for molding the atrial myocardium, interatrial septal myocardium, ventricular myocardium, and interventricular septal myocardium to form heart model halves; and bonding the heart model halves corresponding to the two molding molds together to obtain the simulated heart model.

The utility model relates to the technical field of ventricular septum perforation plugging devices, and discloses a novel ventricular septum perforation plugging device which comprises a fixing column and a first disc-shaped net arranged on the outer side of the fixing column, a connecting waist part is further arranged on the outer side of the fixing column, and the connecting waist part is connected with the first disc-shaped net. A second disc-shaped net is arranged on the side, away from the first disc-shaped net, of the connecting waist part, an end is arranged on one side of the second disc-shaped net, and before use, a small screw at the front end of a transmission steel cable is used for being connected with the end, so that the whole compressed plugging device can be transmitted to a heart defect part through a pipeline; the first disc-shaped net and the second disc-shaped net are used for blocking, the defect part can be blocked, the biological membrane can make contact with the heart defect part, the sealing performance is further improved, meanwhile, the polyurethane coating has certain flexibility, friction between the polyurethane coating and the heart defect part is effectively reduced, and the service life of the heart defect part is prolonged. The heparin coating can reduce the risk of thrombus formation, so that the use risk is reduced.

The application belongs to the technical field of molecular biology, and particularly relates to metabolic markers for evaluating the prognosis of patients with hypertrophic cardiomyopathy and application thereof. The application determines that one or more of 3-hydroxyrilotene, asparagine-lysine, cyclohexylamine, arachidonic acid, aconitic acid, propionyl carnitine, ceramide, tryptophan, 3-hydroxysebacic acid, traumatic acid, phosphatidylcholine, alanine-proline, lysophosphatidylcholine, taurine and S-garlicin cysteine are related to the prognosis of hypertrophic cardiomyopathy, can evaluate the prognosis of patients with hypertrophic cardiomyopathy after undergoing muscle resection of interventricular septum, and shows accurate judgment on all-cause death or rehospitalization, cardiovascular events and postoperative new-onset arrhythmia. Finally, all the prognostic biomarkers are reproduced in an independent cohort, which is helpful for postoperative risk evaluation of patients with hypertrophic cardiomyopathy, has high specificity and high sensitivity.

This invention discloses a method for predicting sudden cardiac death based on forensic autopsy data using machine learning and its forensic applications, belonging to the fields of machine learning, statistics, and forensic identification. This invention provides a method for screening independent predictors of forensic diagnosis of sudden cardiac death using LASSO regression and logistic regression. Using 10-fold cross-validation, the method selects the minimum lambda(λ) to identify 14 risk factors. Logistic regression ultimately identifies 9 independent predictors, including age, heart weight, left ventricular wall thickness, right ventricular wall thickness, interventricular septum thickness, aortic valve circumference, mitral valve circumference, liver weight, and left kidney weight. A nomogram and a web-based calculator are constructed for predicting sudden cardiac death in forensic practice, thereby determining sudden cardiac death using objective indicators. This method has not been reported worldwide.

This invention relates to the field of congenital heart disease treatment technology, and discloses the application of sapropterin in the prevention and treatment of bisphenol fluorene-induced congenital heart disease in fetuses. The congenital heart disease includes cardiac structural defects, heart failure, or cardiomyocyte lesions, specifically selected from ventricular septal defects, atrial septal defects, tetralogy of Fallot, myocardial hypertrophy, decreased cardiac ejection fraction, decreased short-axis contraction rate, cardiomyocyte ferroptosis, myocardial tissue inflammatory infiltration, or myocardial collagen fibrosis. Sapropterin is used as a direct supplement to biological tetrahydropterin (BH4). Through exogenous intervention, it precisely reverses the endogenous BH4 deficiency caused by bisphenol fluorene exposure, restores the expression of GTP cyclase 1 (GCH1) and the dynamic balance of RNA m6A, and upregulates the level of YTH domain family protein 2 (YTHDF2), thereby blocking ferroptosis signal transduction, reducing oxidative stress and inflammatory response, and inhibiting the process of myocardial tissue fibrosis at the molecular level.

Mitral regurgitation can be reduced by creating one passageway between the right atrium and left ventricle in a portion of the tricuspid annulus just above the ventricular septum and another passageway through the outer wall of the left ventricle near at least one of the left ventricular papillary muscles. A support rod is positioned in the right atrium in contact with the septal portion of the tricuspid annulus, and a support plate is positioned adjacent to the second passageway and against the outer wall of the left ventricle. The support plate is pulled toward the support rod using a tether that extends between the first support plate and the support rod, passes through both passageways, and is under tension. The tension in the tether moves the root of the tendon closer to the mitral valve, which reduces mitral regurgitation.

An implantable assembly suitable for remodeling a chamber of a heart in a patient is disclosed. The assembly is implanted with a tool having a tool proximal portion and a distal portion. The assembly includes a mobile anchor including an abutment portion adapted to abut against a wall of the chamber of the heart and a tether portion rotatably coupled to the abutment portion. Each of the abutment portion and the tether portion are configured to be independently coupled from the tool. The assembly further includes an interventricular septum anchor for coupling to a septum of the heart and a tether having a working portion extending between the mobile anchor and the septum anchor having a first length and a tether proximal portion having a second length. The abutment portion is releasably locked to the tether portion and is configured such that a preselected torque applied to the tether portion of the mobile anchor unlocks and causes relative rotation of the tether portion relative to the abutment portion.

A detachable leadless pacemaker system for cardiac conduction bundle pacing is disclosed. The system includes a detachable leadless pacemaker and a passive leadless pacemaker. A hook-shape side electrode is inserted into a ventricular septum for cardiac conduction bundle pacing. The detachable leadless pacemaker may be arranged in a ventricle, and the passive leadless pacemaker may be arranged in an atrium, so as to realize dual-chamber pacing both in the ventricle and in the atrium. The detachable leadless pacemaker is coupled with the passive leadless pacemaker by an anti-tension reinforced wire, which is used for pulling back the detachable leadless pacemaker to a new position.

The invention discloses a direction-adjustable bending radiofrequency ablation electrode needle which comprises an ablation needle handle, a coaxial sheath, a steering electrode needle, an electrode wire, an outflow tube, an inflow tube and a negative electrode patch. The steering electrode needle is arranged in an inner cavity of the ablation needle handle and the coaxial sheath, the steering electrode needle made of shape memory alloy and the coaxial sheath are matched in a push-pull mode to synchronously adjust and control the length and the angle of the electrode needle, the needle point of the electrode needle is coated with the conductive nanometer coating, protein, tissue and the like are prevented from being adhered to the needle point, and carbonization is reduced. The direction of the ablation electrode needle and the length of the working end can be adjusted and controlled, a safer, more effective and more stable operation ablation treatment mode is achieved through the conductive ceramic coating on the needle tip part, the electrode needle can be suitable for Liwen operation type treatment of complex hypertrophic cardiomyopathy ventricular septal parting, and the safety, effectiveness and operability of the Liwen operation type operation process can be improved.

This application provides an ultrasound cardiac dynamic monitoring system and method, relating to the field of ultrasound cardiac function dynamic monitoring technology. The system includes: a patch-type ultrasound probe, a hydrogel patch, a wearable hardware module, and a cardiac function analysis module. The cardiac function analysis module is configured to: receive the ultrasound image; determine a target sampling line in the ultrasound image based on a reinforcement learning model; control the wearable hardware module to acquire M-mode images along the target sampling line; input the M-mode images into a deep learning model to output the key point positions of the left ventricular septum and the left ventricular posterior wall at end-diastole and end-systole based on the deep learning model; calculate the left ventricular ejection fraction (LVEF) based on the LVEF and the key point positions; the LVEF represents the dynamic monitoring and detection results of cardiac function. This system can improve the effectiveness and accuracy of dynamic cardiac monitoring.

The invention discloses myocardial biopsy forceps capable of being bent in two directions, and relates to the technical field of medical instruments, the myocardial biopsy forceps comprise a forceps head assembly and a handle assembly, the handle assembly comprises a bending adjusting device, the bending adjusting device is used for driving a bending adjusting pipe body to bend, and at least two pull wires are arranged in the bending adjusting pipe body; the bend adjusting device comprises a rotating mechanism and a winding mechanism connected with the rotating mechanism, the winding mechanism is connected with two stay wires, the rotating mechanism is rotated forwards to drive the winding mechanism to rotate, and the bend adjusting pipe body is driven to bend forwards through the two stay wires; the rotating mechanism is rotated reversely to drive the winding mechanism to rotate, the bend adjusting pipe body is driven by the two stay wires to bend reversely, the bend adjusting device is operated to rotate to control the bend adjusting pipe body to conduct continuous bend adjusting towards one side or reversely, stress of the stay wires is even, the tong head assembly can be more easily and accurately aligned with the ventricular septum, risks in the alignment process are reduced, and the alignment efficiency is improved. Therefore, the bend adjusting pipe body instantly generates large bending to collide with the ventricular septum, and iatrogenic injury is caused.

Systems, devices, and methods for delivering conductive nanomaterials to a target location in a patient's heart to affect the patient's heart conduction system, such as delivering conductive nanomaterials into the ventricular septum of the patient's heart to improve an impaired heart conduction pathway, such as the left bundle branch.

The invention provides a traditional Chinese medicine composition for treating pulmonary arterial hypertension and application thereof, and belongs to the technical field of traditional Chinese medicine preparation. The traditional Chinese medicine composition for treating pulmonary arterial hypertension is prepared from the following components in parts by weight: 5-7 parts of herba ephedrae, 7-9 parts of semen armeniacae amarae, 20-24 parts of gypsum, 5-7 parts of liquorice root, 9-11 parts of radix salviae miltiorrhizae, 0.8-1.2 parts of leech and 2.5-3.5 parts of radix notoginseng. According to the treatment principle of freeing lung, relieving asthma and promoting blood circulation to remove blood stasis, ephedra, apricot kernel, gypsum and licorice granules with the effects of freeing lung, clearing heat and relieving asthma are used as monarch drugs, and salvia miltiorrhiza, leech and pseudo-ginseng with the effects of promoting blood circulation to remove blood stasis are used as ministerial drugs for compatibility; the prepared traditional Chinese medicine composition can reduce the length ratio of the right ventricle to the left ventricle plus ventricular septum and the length ratio of the right ventricle to the tibia, inhibit right ventricular hypertrophy, repair pulmonary vascular injury and improve the pulmonary ventilation function, the cardio-pulmonary function and pulmonary arterial hypertension.

The present disclosure includes devices and techniques for threading one or more catheters to the apex or base of the right ventricle by transfemoral vein access to the right ventricle. The catheter can be passed through to turn upward, directed towards the mitral valve, by puncturing the ventricular septum into the left ventricle through the ventricular side or right side of the heart. From this entry point in the left ventricle, flail mitral valve leaflets can be sutured and tethered, pulled back into place, and re-attached with grounding anchors in the right ventricle, or embedded in the septal wall. The ventricular septal crossing technique may include passing a coaxial conduit through a first access conduit, where the first access conduit may act as a guide to direct an inner or second coaxial conduit toward a flail mitral valve leaflet.

The invention provides an ablation needle assembly and an ablation system. The ablation needle comprises an electrode needle main body and an ablation handle connected with the near end of the electrode needle main body, the electrode needle main body is movably arranged in the outer sleeve in a penetrating manner, and a limiting part is arranged on the outer sleeve to limit the ablation direction of the ablation needle. The far end face of the outer sleeve is connected with a conductive section which extends towards the side away from the outer sleeve in the axial direction of the outer sleeve, and the limiting part is one or more insulating layers which are arranged in the axial direction of the conductive section and partially cover the conductive section. Or the limiting part is one or a plurality of insulating strips which are axially connected to part of the far-end end face of the outer sleeve along the outer sleeve, the plurality of insulating strips are arranged at intervals around the axis of the outer sleeve, and a hollow part is formed on the far side of the part, which is not connected with the insulating strips, of the far-end end face of the outer sleeve. When the ablation needle assembly is applied to ablation treatment of HCM, the ablation direction of the ablation needle can be kept away from the thickness direction of the ventricular septum, and therefore the situation that the ablation needle ablates in the thickness direction of the ventricular septum and penetrates through the endocardium is avoided.

The utility model relates to the technical field of medical instruments, in particular to a ventricular septal defect treatment instrument. The ventricular septal defect treatment instrument comprises a patch, a conveying sheath tube, a push rod and a limiting piece, the patch is arranged in the conveying sheath tube after being compressed, and is positioned at the first end of the conveying sheath tube; the limiting piece is arranged at the second end of the conveying sheath tube, and a through hole allowing the push rod to penetrate through is formed in the limiting piece; the push rod is used for pushing the patch out of the conveying sheath tube. According to the technical scheme, the patch is compressed in the conveying sheath tube, the position of the ventricular septal defect is detected through the head of the conveying sheath tube, the patch can conveniently pass through a small ventricular defect, then the push rod is operated to release the patch, the released patch can be fixed to the left ventricular surface of the ventricular septal through the suture line or the fixing claw, and therefore repairing of the ventricular septal defect is completed.

The present application relates to the field of medical image processing, particularly to a four-dimensional echocardiogram dynamic segmentation system for congenital heart disease, which acquires four-dimensional echocardiogram data of a fetal heart through an image acquisition module, corrects fetal movement artifacts by using optical flow field time series analysis technology in an optical flow field correction module, improves image quality, aligns heart structures and extracts interventricular septal defect regions through a multi-scale similarity transformation strategy in a heart structure time series alignment module, calculates the edge line diameter and shunt direction of the defect site in a defect analysis module, generates defect parameter information, and generates a congenital heart disease screening report in a result output module, which effectively eliminates image artifacts caused by fetal movement, lays a foundation for subsequent analysis, and accurately analyzes by accurately aligning heart structures to keep the defect site in a stable position in the time sequence.

A system for percutaneous ventriculoplasty. Anchors can be placed in the ventricular septum and the ventricular wall. Sutures tethered to the anchors can be tensioned to reduce the size of a dilated left ventricle. Multiple anchors can be positioned in the ventricular wall and the sutures can be independently tensioned to allow tailored treatment of the dilated ventricle.

During a cardiac arrhythmia, defibrillation shocks from an implanted cardiac defibrillator are suppressed based on the sensing of electrical wavefront arrival times which indicate a supraventricular origin to the cardiac arrhythmia. In some embodiments, times of electrical wavefront arrival in at least two ventricular locations of the heart are sensed; one location being relatively superior, and one relatively inferior (e.g., relatively superior and inferior locations of a ventricular septum). In some embodiments, if the arrival time at the more inferior position is within a predetermined interval after arrival at the more superior position, delivery of defibrillation shocks are suppressed. In some embodiments, additional sensing of electrical wavefront arrival at one or more non-septal ventricular locations is performed, and defibrillation shock suppression is optionally itself suppressed if the additional sensing indicates that the wavefront initiated in a ventricular location.

A method for providing therapeutic treatment to reduce pre-load may be provided. The method may include placing a ventricular assist device (VAD) at least partially within a left ventricle or a right ventricle of a patient, and placing a catheter-based device including an adjustable flow limiting element (FRE) such that the FRE is disposed within a superior vena cava (SVC) of the patient. The method may include receiving information from the VAD and / or conduit-based FRE device, determining a first determination value based on the information, and controlling at least one performance parameter of the VAD and / or conduit-based device based on the first determination value.

The application relates to the field of medical devices, in particular to a heart valve prosthesis fixed through an interventricular septum, comprising a valve support and a fixing device, the valve support comprising a valve sewing section and an artificial valve, the artificial valve being fixedly connected to the valve sewing section, the fixing device comprising a fixing support section and a fixing member, one end of the fixing support section being connected to a proximal end portion of the valve sewing section, the other end of the fixing support section being connected to the interventricular septum of a patient through the fixing member to support the heart valve prosthesis and limit axial movement of the heart valve prosthesis.

The application relates to a simulation-based target resection region determination method and device. The method comprises the following steps: obtaining a heart simulation model and corresponding blood flow field information; determining a first target region in an interventricular septum model according to a left heart lumen model and the blood flow field information; performing stress calculation according to the interventricular septum model to determine a second target region in the interventricular septum model; determining an initial target region according to the first target region and the second target region; determining a thickness range of the initial target region at a time point of the end-systole according to the interventricular septum model; determining a target resection thickness according to a preset basic thickness and the thickness range; and determining a first target resection region according to the heart simulation model, the initial target region, the target resection thickness and the blood flow field information. The method can accurately determine a myocardial tissue region required to be resected.

During a cardiac arrhythmia, defibrillation shocks from an implanted cardiac defibrillator are suppressed based on the sensing of electrical wavefront arrival times which indicate a supraventricular origin to the cardiac arrhythmia. In some embodiments, times of electrical wavefront arrival in at least two ventricular locations of the heart are sensed; one location being relatively superior, and one relatively inferior (e.g., relatively superior and inferior locations of a ventricular septum). In some embodiments, if the arrival time at the more inferior position is within a predetermined interval after arrival at the more superior position, delivery of defibrillation shocks are suppressed. In some embodiments, additional sensing of electrical wavefront arrival at one or more non-septal ventricular locations is performed, and defibrillation shock suppression is optionally itself suppressed if the additional sensing indicates that the wavefront initiated in a ventricular location.

The application relates to a method and device for determining the thickness of the interventricular septum, a computer device and a storage medium. The method comprises the following steps: acquiring a heart scan image, performing image segmentation on the heart scan image by using an image segmentation model, and determining a segmentation mask of a target detection region in the heart scan image; converting the segmentation mask of the target detection region by using a moving cube algorithm, and determining target three-dimensional point cloud data corresponding to each segmentation mask; determining key point position information of a heart key point according to the target three-dimensional point cloud data and a key point detection model; determining the position information of a three-dimensional section of a left ventricular interventricular septum region according to the key point position information; the three-dimensional section comprises a mitral valve horizontal short-axis section, a left ventricular long-axis section and a four-chamber heart section; and determining the thickness of the interventricular septum of the left ventricular interventricular septum region according to the position information of the three-dimensional section. The above scheme improves the accuracy of the determined thickness of the interventricular septum.

A method may be provided for providing a therapeutic measure to reduce preload. The method may include placing a ventricular assist device (VAD) at least partially inside either the patient's left or right ventricle, and placing a catheter-based device including an adjustable flow-limiting element (PRE) such that the PRE is placed inside the patient's superior vena cava (SVC). The method may include receiving information from the VAD and / or catheter-based PRE device, determining a first determination value based on the information, and controlling at least one performance parameter of the VAD and / or catheter-based device based on the first determination value.

Embodiments described herein include devices, systems, and methods for reducing the distance between two locations in tissue. In one embodiment, an anchor may reside within the right ventricle in engagement with the septum. A tension member may extend from that anchor through the septum and an exterior wall of the left ventricle to a second anchor disposed along a surface of the heart. Perforating the exterior wall and the septum from an epicardial approach can provide control over the reshaping of the ventricular chamber. Guiding deployment of the implant from along the epicardial access path and another access path into and through the right ventricle provides control over the movement of the anchor within the ventricle. The joined epicardial pathway and right atrial pathway allows the tension member to be advanced into the heart through the right atrium and pulled into engagement along the epicardial access path.

The present application relates to the field of medical devices, and provides an ablation catheter and an ablation system comprising the same, the ablation catheter comprising a penetrating part, an ablation main body, a catheter main body and a control handle connected in sequence; the penetrating part comprises a screwing-in member capable of screwing into and being fixed to a target tissue under the action of an external force; the ablation main body comprises an ablation electrode, a connecting member and a temperature sensor; the catheter main body comprises a non-ablation electrode and a perfusion channel; the non-ablation electrode is arranged in a spaced manner with the ablation electrode, and the non-ablation electrode is not in contact with the target tissue during ablation. By using the ablation catheter and the ablation system, the thickened interventricular septum is screwed and ablated, the screwing speed is easier to control, the depth can be stopped or adjusted in time before penetrating the myocardial wall, myocardial perforation can be prevented, and the damage to the myocardial tissue is reduced through temperature detection and perfusion function.

The application relates to a method and device for determining the thickness of the interventricular septum, a computer device and a storage medium. The method comprises the following steps: acquiring a heart scan image, performing image segmentation on the heart scan image by using an image segmentation model, and determining a segmentation mask of a target detection region in the heart scan image; converting the segmentation mask of the target detection region by using a moving cube algorithm, and determining target three-dimensional point cloud data corresponding to each segmentation mask; determining key point position information of a heart key point according to the target three-dimensional point cloud data and a key point detection model; determining the position information of a three-dimensional section of a left ventricular interventricular septum region according to the key point position information; the three-dimensional section comprises a mitral valve horizontal short-axis section, a left ventricular long-axis section and a four-chamber heart section; and determining the thickness of the interventricular septum of the left ventricular interventricular septum region according to the position information of the three-dimensional section. The above scheme improves the accuracy of the determined thickness of the interventricular septum.

This invention relates to a method and apparatus for processing characteristic dimensions based on cardiac ultrasound video measurements. The method includes: receiving a first video; extracting video frame images; detecting key points in each frame image based on a key point detection model; filtering diastolic and systolic frame images; filtering mid-systolic ventricular frame images; annotating key points and characteristic dimensions of the right ventricular diameter, interventricular septum thickness, left ventricular diameter, and left ventricular posterior wall thickness on the diastolic frame images; annotating key points and characteristic dimensions of the left ventricular diameter on the systolic frame images; annotating key points and characteristic dimensions of the left atrial anteroposterior diameter, aortic valve annulus diameter, aortic sinus diameter, and ascending aortic diameter on the mid-systolic ventricular frame images; and outputting the annotated diastolic, systolic, and mid-systolic ventricular frame images as the processing result. This invention can solve the problem of manual intervention in conventional methods and improve measurement efficiency.