157 results about "Heart apex" patented technology

The invention relates to the technical field of medical image analysis, in particular to a left ventricular compliance assessment method and system based on medical image.The method comprises the following steps that a planar three-dimensional coordinate from a left ventricular apex to a mitral annulus is obtained through a CT image, a thin-plate spline interpolation algorithm is called to establish a left ventricular long-axis model, the ultrasonic end-stage internal diameter is obtained synchronously, and a left ventricular compliance assessment result is obtained. And inputting the left greenhouse long axis model and the ultrasonic diastole end-stage inner diameter into an Euclidean distance calculation function to generate a left greenhouse length-diameter ratio. According to the method, a left greenhouse long axis model is constructed by integrating CT three-dimensional coordinates and ultrasonic inner diameter, the length-diameter ratio is calculated by combining Euclidean distance, point cloud registration is carried out, a myocardial wall area is segmented, local deformation is quantized by utilizing Gaussian curvature gradient, a correction factor is generated by inputting a radial basis function network, and a parameter coupling mechanism is established by fusing an aorta root angle. And optimizing the weight of the pressure-volume equation, establishing a dynamic model, and realizing a quantitative evaluation system of spatial heterogeneity and time continuity.

The invention provides a left heart data analysis method and system based on image segmentation, and relates to the technical field of medical image processing. Comprising the following steps: acquiring cardiac ultrasound image data and preprocessing; performing image segmentation on the preprocessed image data to obtain a segmentation result including a left ventricle, a left ventricular wall and a left atrium; searching a boundary line of the left ventricle and the left atrium, selecting two boundary points corresponding to the minimum and maximum abscissas in the boundary line as left and right mitral valve ring points respectively, and establishing a long axis based on the mitral valve ring midpoint and the cardiac apex point; modeling the ventricle into a structure formed by superposing a plurality of discs along the long axis direction, and obtaining the diameter of the corresponding disc; based on the obtained diameters of the corresponding discs, the left ventricular volumes in the diastolic period and the systolic period are calculated respectively, and the left ventricular ejection fraction is calculated. According to the method, image segmentation and geometric modeling are fused to achieve accurate calculation of the cardiac ejection fraction, meanwhile, the accuracy of cardiac structure image segmentation is improved, and an interpretable ejection fraction estimation process is achieved.

The invention relates to a medical image processing method and device and ultrasonic equipment. The method comprises the following steps: acquiring a preset imaging sequence comprising at least two imaging modes; the preset imaging sequence represents an imaging sequence between the at least two imaging modes; based on the preset imaging sequence, performing ultrasonic imaging on a target object, and determining a cardiac apex four-cavity tangent plane meeting a first preset condition in each imaging mode; determining cardiac function parameters of the target object according to the cardiac apex four-cavity cardiac tangent surfaces; and obtaining a cardiac function evaluation result of the target object according to the cardiac function parameters. By adopting the method, the time consumption of ultrasonic imaging and cardiac function evaluation can be reduced.

An inner conveying catheter is movably arranged in an inner cavity of an outer conveying catheter in a penetrating mode, the inner conveying catheter comprises a first main body catheter section and a first bending adjusting catheter section in the axial direction of the inner conveying catheter, the far end of the first main body catheter section is connected with the near end of the first bending adjusting catheter section, and the first bending adjusting catheter section has the bendable function; the inner control silk thread is connected with the first bending adjusting pipe section and used for controlling the first bending adjusting pipe section to be bent actively, and the pushing inner core rod piece is movably arranged in an inner cavity of the inner conveying guide pipe in a penetrating mode. Therefore, the artificial valve ring has good regulation and delivery performance, the multi-angle space regulation performance of the artificial valve ring effectively improves the success rate of a mitral valve replacement operation, the mitral valve replacement operation can be carried out in various ways such as femoral artery, atrial septum (femoral vein) and cardiac apex, the release paths of the artificial valve ring are diversified, and the artificial valve ring has good application prospects. The operation range is greatly widened, the operation method is simple and easy to learn, and the learning curve and the operation duration of an operator can be effectively shortened.

The invention provides an integrated structure double-ventricle independent auxiliary device and an implantation method. The device comprises double inlet paths and double outlet paths which are connected, the double inlet paths are of a double-cavity structure and comprise an inner cavity and an outer cavity, the double inlet paths are implanted through the apex of the left ventricle, the inner cavity is inserted into the apex of the funnel of the right ventricle through the corresponding ventricular septum at the opening of the left ventricle, and the outer cavity is reserved in the left ventricle; and the double outlets are respectively connected with the aorta and the pulmonary artery through the artificial blood vessel by a circulation driving device. Left and right artificial ventricle admission passages are located in the heart, and channel distortion, large blood damage and proneness to thrombus caused by long admission passages are avoided; unsmooth drainage of a right chamber or right ventricle admission passage can be avoided; the right chamber is not damaged; the whole device is small in size and convenient to implant.

Methods and systems are provided for identifying cardiac cycles for evaluating left ventricle function using only image data. In one example, a method includes obtaining a sequence of medical image frames of a heart of a patient over a plurality of cardiac cycles, wherein each medical image frame depicts the same apical view of the heart, using a timing model to generate an output that is useable to label each frame of the sequence by cardiac cycle subphase and using the output to determine the suitability of each cardiac cycle for performing an automated measurement. The method may further include using the suitability of each cycle to determine if an automated measurement should be performed on each cycle, where automated measurements are performed on medical image frames corresponding to suitable cycles and automated measurements are not performed on medical image frames corresponding to unsuitable cycles.

Various embodiments include methods for generating patient-specific heart and thorax models using anatomical landmarks and segmentation data, optimized through the application of trained neural network models. Three-dimensional medical imaging data may be processed by a trained neural network to automatically segment and isolate the heart, blood cavities, and thorax to extract feature maps from the segmented images. Anatomical landmarks, such as the heart apex and valve centers, are identified and the alignment of heart axes is verified. Reference heart and thorax models are selected and adapted to fit the patient-specific landmarks through scaling, translating, and rotating. Best adapted heart and thorax models may then be used for conducting one or more medical procedures. Neural network models, trained on historical patient data sets, may be refined through machine learning from new patient data, thereby improving accuracy.

The invention relates to application of piRNA-AB352916 and a mimetic thereof in preparation of a medicine for treating ischemic heart disease, and belongs to the technical field of medicines. In order to solve the problem that a medicine capable of promoting myocardial cell proliferation and inhibiting myocardial cell apoptosis is lacked in the treatment process of the ischemic heart disease, the invention provides application of piRNA-AB352916 and a mimetic thereof in preparation of a medicine for treating the ischemic heart disease. According to the application disclosed by the invention, the expression level of the piRNA-AB352916 in myocardial regeneration model tissues after cardiac apex resection is obviously increased, and animal experiments prove that the myocardial specific overexpression piRNA-AB352916 not only can promote myocardial cell proliferation, but also can inhibit myocardial cell apoptosis, so that the myocardial infarction area is reduced, and the cardiac function of an infarction mouse is improved. The invention proves that the piRNA-AB352916 and the analogue thereof have prevention and treatment values on the ischemic heart disease.

An apparatus, comprising: a blood pump, comprising: an axial shaft (92) configured for insertion into, and rotation within, a left ventricle of a subject; an impeller (50) coupled to the axial shaft such that, as the axial shaft (92) rotates, the impeller (50) pumps blood from the left ventricle; a frame (34) surrounding the impeller (50); and a tip portion (120) coupled to a distal end of the frame (34) and comprising: a distal curved portion (349), which is configured, when deployed within the left ventricle, to lie in a plane; and a proximal curved portion (350), which is configured, when deployed within the left ventricle, not to lie in the plane and to be curved such that an angle between a distal end of the proximal curved portion (350) and the axial shaft (92) is between 100 and 170 degrees, such that the distal end of the proximal curved portion (350) points toward an apex of the left ventricle.

The invention discloses application of a JMJD6-targeted reagent in preparation of a medicine for promoting myocardial cell proliferation. The medicine can promote myocardial cell proliferation after myocardial infarction and reduce the myocardial fibrosis scar area caused by myocardial infarction. AAV9 myocardial specific overexpression virus and JMJD6 myocardial specific knockout mice are utilized, and the positive effect of JMJD6 in promotion of P1 cardiac apex resection of newborn mice and regeneration and repair of injured hearts after myocardial infarction of adult mice is disclosed for the first time; the specific mechanism is that JMJD6 depends on the activity of histone demethylase, enrichment of active modification H4R3me2a and H3R2me2s in a PDK4 promoter region is removed, transcriptional expression of the H4R3me2a and the H3R2me2s is inhibited, an impaired heart energy substrate utilization mode is stimulated to be increased and converted from fatty acid oxidation energy supply to glycolysis oxidation energy supply, and then adult myocardial cell proliferation is effectively promoted. The regeneration and repair capability of the heart after myocardial infarction is greatly improved, and a new effective target spot is provided for clinical treatment of myocardial injury.

A heart surgery preset soft sheath for interventional therapy through a cardiac apex way comprises a sheath tube and a large head part arranged at the rear end of the sheath tube, the sheath tube is communicated with an inner cavity of the large head part, an air bag is arranged on the outer side face of the front end of the sheath tube, a plurality of sets of narrow kerfs and small holes which are communicated front and back are formed in the peripheral side of the large head part, and the narrow kerfs and the small holes in each set are in one-to-one correspondence. A containing cavity is formed in the large head portion, a blood blocking valve is arranged on a base of the containing cavity, a port is formed in the outer end of the large head portion, and in a free state, the blood blocking valve blocks the port. Through the structural design, the depth of the hemostasis purse-string can be limited, the hemostasis purse-string can be limited on the cardiac muscle, the sheath tube cannot slip off in the operation process, the hemostasis purse-string is integrally made of medical silica gel with the hardness of 50-65 degrees, the influence on contraction and expansion of the cardiac muscle is small, and the operation line of the hemostasis purse-string is tensioned and clamped and fixed on the large head after puncture. The hydrophilic films on the air bag and the sheathing canal can reduce damage to the cardiac muscle in the placing and taking-out process.

Systems and methods are provided herein for improving connections between a heart pump, such a left ventricular assist device (LVAD), and the heart and / or tubing such as a graft tube. An apical connector including a cylindrical housing and a ring support connected to the housing is described. The apical connector may include a sewing ring to be connected to the patient's heart and a spring positioned within the cylindrical housing to engage a portion of the pump and secure the apical connector to the pump. Alternatively, an apical connector may include an upper and lower housing with locks positioned in channels between the housings and may include a handle and a ring to cause the locks to engage a portion of the pump. A quick connect assembly is also described for efficiently connecting a graft tube to an outlet of a heart pump using a flange with through-holes and protrusions.

The utility model relates to the technical field of medical instruments, in particular to a pacemaker electrode wire, which comprises a wire conduit, the wire conduit comprises a head part and a tail part which are connected with each other, the head part is provided with an electrode assembly, and the electrode assembly comprises a first electrode and a second electrode which are electrically connected with each other. The first electrode and the second electrode are arranged in a spaced mode in the direction from the head to the tail, and a fixing piece located between the first electrode and the second electrode is arranged on the outer side of the wire conduit. The head of the wire conduit can be sent to the right ventricular apex of the heart of a patient through vein puncture, and the fixing piece is in contact with and fixed to the surface of the endocardium, so that the first electrode is firmly fixed to the right ventricular apex, the electrode wire is kept stable in the heart of the patient, and the electrode wire is prevented from shifting or falling off; and the normal cardiac function of the patient is ensured.

A biostimulator and a biostimulator system for septal pacing, is described. The biostimulator includes an articulation to allow an electrode axis of a pacing electrode to be directed differently than a housing axis of a housing. The housing contains electrical circuitry that is electrically connected to the pacing electrode. The differently directed axes allow the pacing electrode to affix to target tissue of an interventricular septal wall of a heart when the housing of the biostimulator is located near an apex of the heart. The articulation can include a flexible portion of an extension, a hinge, or a tether. Other embodiments are also described and claimed.

A biostimulator and a biostimulator system for septal pacing, is described. The biostimulator includes an articulation to allow an electrode axis of a pacing electrode to be directed differently than a housing axis of a housing. The housing contains electrical circuitry that is electrically connected to the pacing electrode. The differently directed axes allow the pacing electrode to affix to target tissue of an interventricular septal wall of a heart when the housing of the biostimulator is located near an apex of the heart. The articulation can include a flexible portion of an extension, a hinge, or a tether. Other embodiments are also described and claimed.

The invention relates to the field of coronary artery scanning, and discloses a coronary artery scanning control method and system based on deep learning, and the method comprises the steps: obtaining a diaphragm motion image, a left ventricular myocardial motion image, a right ventricular myocardial motion image and a cardiac apex motion image of a patient, and obtaining an arrhythmia monitoring index of the patient through ECG calibration; determining the diaphragm motion characteristics of the patient through the diaphragm motion image, determining the left ventricular myocardial motion characteristics of the patient through the left ventricular myocardial motion image, determining the right ventricular myocardial motion characteristics of the patient through the right ventricular myocardial motion image, and determining the cardiac apex motion characteristics of the patient through the cardiac apex motion image; and determining a coronary artery navigation mode of the patient according to the arrhythmia monitoring indexes, the diaphragm motion characteristics, the left ventricular myocardial motion characteristics, the right ventricular myocardial motion characteristics and the cardiac apex motion characteristics through a navigation prediction model. According to the method and the device, the MRCA examination accuracy and examination efficiency under the conditions of irregular respiration and arrhythmia are improved.

The utility model discloses a fixing strap for a temporary pacemaker, which comprises a shoulder strap and a binding strap, an extension bag is sewed below the shoulder strap, a zipper is sewed on the surface of the extension bag, a weight is stored in the extension bag, and a binding surface is arranged at the bottom end of the extension bag; a traction piece is arranged on the surface of the extension bag and used for changing the position of the extension bag, and the fixing band is used in cooperation with the fixing band at the position, close to the apex of the right ventricle, of the extension bag after being worn, so that the fixing band can keep a good attaching effect whether daily activities or mild exercises are carried out; and the risk of complications caused by displacement of the pacemaker or poor contact of the electrodes is reduced. The bonding head is bonded to the bonding female end area by pulling the traction belt, it can be ensured that the position of the extension bag after adjustment is kept stable, that is, the position of the extension bag is changed through traction of the traction belt, and the position of the extension bag is accurately adjusted.

The application relates to the field of medical devices, in particular to an implant capable of avoiding interlayer reflux, which comprises an anchoring device, a closing aid, and an adjusting mechanism, the closing aid is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closing aid, and the other end of the adjusting mechanism is fixed on ventricular tissue or apical tissue, the closing aid comprises a first patch and a second patch, one side of the first patch close to the anchoring device is a root, and the other side of the first patch away from the anchoring device is a head, wherein the first patch is arranged above the second patch, and the first patch and the second patch cooperate to form a pocket structure with an opening direction towards the head direction; the application can effectively avoid the existence of a gap between the closing aid and the autologous valve leaflet, so that blood flowing into the gap can be prevented from being accumulated into thrombus, calcified and other adverse conditions, and the application has good clinical significance.

A volume management apparatus includes a cardiac evaluation unit configured to evaluate whether the patient suffers from an organic heart disease based on an image of apical four chamber view; a parameter determination unit configured to determine a maximum inner diameter of inferior vena cava and a collapse rate of inferior vena cava based on an image of subxiphoid inferior vena cava view; a score calculation unit configured to determine scores that correspond to the LVEF value, the maximum diameter of the inferior vena cava, and the collapse rate of the inferior vena cava, respectively; and a fluid management plan determination unit configured to search for a fluid management plan corresponding to a score determined, and to perform volume management for the patient according to the fluid management plan searched.

The invention relates to the field of medical instruments, in particular to an implant capable of avoiding interlayer regurgitation, which comprises an anchoring device, a closure assisting part and an adjusting mechanism, the closure assisting part is fixed on atrial tissue through the anchoring device, one end of the adjusting mechanism is connected with the closure assisting part, and the other end of the adjusting mechanism is connected with the closure assisting part. One end of the adjusting mechanism is fixed to ventricular tissue or cardiac apex tissue, the closure assisting piece comprises a first patch and a second patch, the side, close to the anchoring device, of the first patch is a root part, the side, away from the anchoring device, of the first patch is a head part, the first patch is arranged above the second patch, and the second patch is arranged above the head part. The first patch and the second patch are matched to form a pocket structure with an opening facing the head; the closure assisting device can effectively avoid the unfavorable conditions of thrombus accumulation, calcification and the like caused by the fact that blood flows into a gap due to the gap between the closure assisting part and the autologous valve leaflet, and has very good clinical significance.

The invention provides a coronary heart disease echocardiogram pathological feature extraction method and system. Static structure features and myocardial function features of the heart of a target coronary heart disease patient are determined through an ultrasonic video stream of the heart of the target coronary heart disease patient; determining a region mapping matrix of a relationship between a coronary artery blood supply region of the target coronary heart disease patient and a myocardial injury state according to the static structural characteristics and the myocardial functional characteristics, and determining boundary sharpening development of a pathological region in the heart of the target coronary heart disease patient according to the region mapping matrix; acquiring a myocardial movement track of the target coronary heart disease patient, and determining a longitudinal strain gradient of a basal segment and a cardiac apex segment of the heart of the target coronary heart disease patient according to the myocardial movement track; and based on the boundary sharpening development and the longitudinal strain gradient of the pathological area and in combination with the clinical pathological data of the target coronary heart disease patient, generating the cardiac physical characteristics of the target coronary heart disease patient. According to the scheme, the static structure and the dynamic function of the heart can be effectively associated and fused to extract the coronary heart disease echocardiogram features.

This invention relates to the field of image segmentation technology, and in particular to a method, apparatus, device, and storage medium for segmenting three-dimensional heart images. The method includes: extracting the intermediate layer region of interest (ROI) of the three-dimensional heart image to be segmented using a preset intermediate layer segmentation model; spreading the intermediate layer ROI to the basal and apical layers of the three-dimensional heart image to be segmented to obtain an overall ROI image; and segmenting the overall ROI image using a preset overall segmentation model to obtain a segmentation result for the three-dimensional heart image to be segmented. Because this invention first segments the intermediate layer image of the three-dimensional heart image to be segmented, then spreads the segmentation result to the entire three-dimensional heart image to be segmented, and finally segments the entire three-dimensional heart image to obtain a segmentation result, compared with existing methods, this invention can reduce the image data involved in segmentation and improve the accuracy of the segmentation result.

This invention discloses an adjustable ventricular connection device for mounting a blood pump at the apex of the heart. It includes an apical suture assembly for suturing to the apex of the heart and a blood pump connection assembly. The apical suture assembly includes a suture ring and an elastic outer suture ring. The outer suture ring is fixedly connected to the suture ring and both are fitted onto the inlet tube of the blood pump, with the inner ring of the outer suture ring sealingly fitting against the outer wall of the inlet tube. The blood pump connection assembly includes an adjusting and fixing ring and a fastener. The adjusting and fixing ring is fitted onto the inlet tube and fixedly connected to the suture ring. The fastener secures the adjusting and fixing ring to the inlet tube, and its position on the inlet tube can be adjusted by loosening the fastener. This invention allows adjustment of the position of the apical suture assembly and the blood pump connection assembly on the inlet tube, enabling adjustment of the optimal insertion depth of the inlet tube into the ventricle according to the myocardial thickness of different patients, achieving individualized treatment to meet the needs of patients with different myocardial thicknesses.

The utility model provides a heart volume reduction implant and a conveyor, which relates to the technical field of medical instruments and comprises an isolation umbrella body, a connecting mechanism and a fixed base, the isolation umbrella body is connected with the fixed base through the connecting mechanism, the isolation umbrella body can isolate an invalid cardiac cavity, the connecting mechanism is provided with a hollow channel for the conveyor to penetrate through, the conveyor can sequentially penetrate through the isolation umbrella body and the hollow channel, and the fixed base can expand and support the interior of the cardiac cavity under the action of the conveyor; the conveyor can directly penetrate through the isolation umbrella body to be matched with the fixed base through the hollow channel, the expansion form of the fixed base can be adjusted through the conveyor, and then the good adaptability and stability of the fixed base to heart cavities of different sizes and forms are achieved; the technical problems that in the prior art, due to the fact that an umbrella body is fixed through edge anchor thorns, stability is low, and damage to the heart is large when the umbrella body is fixed through the cardiac apex are solved.

Provided is a health monitoring device that extracts, in particular, an apical beat component from a trunk acoustic pulse wave and thus is also usable in the medical field. The health monitoring device (1000) of the present invention analyzes a trunk acoustic pulse wave to estimate the health condition of a person using a correlation of an indicator relating to a left ventricular pressure waveform which indicates the behavior of the heart, with a vibration frequency of a frequency component stemming from an apical beat, a diastolic time interval in a cardiac cycle, or blood pressure. The former is input information and the latter is output information of the heart through which blood circulates, and thus comparing these two pieces of information makes it possible to know a health condition relating to the function of the heart more accurately than conventionally.

A transapical removal device that can be deployed in a catheter procedure to capture for removal or alteration a mitral valve clip or heart tissue, such as the anterior leaflet of the mitral valve, and methods of use are disclosed. The removal device includes a delivery catheter configured to be deployed near a mitral valve using a guide catheter. The delivery catheter has a snare head at the distal end, which assumes a collapsed state during movement of the delivery catheter through the guide catheter and deployed state for capturing a mitral valve clip or anterior leaflet. The snare head has one or more ablation delivery catheters configured to ablate tissue surrounding the pre-positioned mitral valve clip or anterior leaflet. In some arrangements within the scope of the present disclosure, the removal device includes a deployment mechanism for deploying a new transcatheter valve into the mitral valve.

The present invention provides a method, system, medium and electronic device for apex calibration based on magnetocardiogram, the method comprising the following steps: acquiring target data, the target data comprising magnetocardiogram data and angiography image data; performing gradient calculation based on the magnetocardiogram data to obtain a first apex point; reconstructing a heart model based on the angiography image, thereby obtaining a second apex point based on the heart model; performing coordinate conversion based on the first apex point and the second apex point to complete the calibration of the apex. The method, system, medium and electronic device for apex calibration based on magnetocardiogram of the present invention can solve the problems in the prior art of CT and MCG data calibration deviation caused by manual positioning, inability to use past CT and MCG data for retrospective analysis, and difficulty in batch processing of data calibration; at the same time, large quantities of data can also be automatically processed in batches, which is convenient and efficient, and can assist in the diagnosis of heart diseases and preoperative guidance.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and / or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.

The utility model discloses a catheter sealing device for transcardiac apex first aid. The catheter sealing device comprises a telescopic disc made of a shape memory alloy material and a spiral push rod used for achieving state change of the telescopic disc. The telescopic disc is provided with anchoring claws and developing rings distributed in the circumferential direction. The telescopic disc has an unfolded state and a closed state, and the telescopic disc is pre-shaped into a shape in the closed state; in the unfolded state, the telescopic disc is in a hexagonal plum blossom shape, in the closed state, the telescopic disc is provided with an inwards-concave triangle and an outwards-protruding triangle, each corner is in threaded connection with a spiral push rod, and the inwards-concave triangles can be unfolded under the pulling action of the spiral push rods, so that the telescopic disc is converted into the unfolded state from the closed state. The device is simple in structure, easy and convenient to operate and capable of rapidly opening and closing a cardiac apex channel, sealing a catheter and reducing bleeding when being used for transapical cardiac apex first aid.

An implantable medical device delivery system includes a delivery catheter including an elongated body having a first portion defining a first lumen and a second portion defining a second lumen. An angle is defined between first and second axes defined by the first and second portions, respectively. The second axis is directed toward a left ventricular (LV) apex of a heart of a patient when the first axis is directed toward a CS. The first portion or elongated element can extend into the CS to anchor the delivery catheter relative to an orientation of the CS.