9688 results about "Rat heart" patented technology

Methods and apparatus for determining a position of an intracardiac blood pump in a patient are described. The method includes receiving from at least one capacitive sensor associated with a cannula of the intracardiac blood pump, at least one capacitive signal, determining a position of the intracardiac blood pump in the patient based, at least in part, on the at least one capacitive signal, and providing an indication of the position of the intracardiac blood pump on a user interface of the circulatory support device.

Set forth are vascular valves and servovalves and methods of using the same that may be positioned in the circulatory system without interrupting blood flow to facilitate solid organ transplantation so as to reduce graft organ anoxia and degradation before and after harvesting and storage, thereby minimizing late-term cardiac allograft vasculopathy as a major cause of graft failure. Along the urinary tract, bypassing bladder-generated urge sensation by diverting urine directly from the ureters to a neobladder or collection bag alleviates intractable incontinence, nocturia, urethral syndrome, overactive bladder, dysuria, or frequency. Where the lower tract is missing, a prosthesis can thwart disease and preclude the degenerative metaplastic transition to carcinoma risked when gut is used to construct a conduit for urine, a neobladder, and / or high-maintenance stoma. Druglines to valves and servovalves can directly pipeline-target medication to nidi, anastomoses, or any other trouble spots.

Systems and methods are provided herein for monitoring electrical activity in ex vivo, resting donor organs. Systems and methods provided herein also include providing electrical stimulation to the donor tissue to maintain or increase viability during storage or transport. Donor organs can include ex vivo, resting hearts. Electrical activity can be used to determine donor organ viability, especially in instances where visual evaluation of a beating heart is not possible. The same electrodes or other sensing devices used to measure electrical activity can be used to apply a voltage / current to the tissue as well in order to maintain viability of the organ. In some embodiments, stimulation or depression may be provided in response to the measured electrical activity.

Systems and methods are described herein relating to an intracardiac blood pump system comprising a pump, an elongate multi-lumen catheter, a compartment connected to the catheter, a first lumen, a conduit and a filter disposed within the conduit. At least one electronic element is located within the compartment. The conduit extends through an interface between the compartment and the catheter. The conduit is configured to allow gas to penetrate from a first end of the conduit through the first opening of the compartment to a second end of the conduit. The second end of the conduit is in fluid communication with a central lumen of the elongate multi-lumen catheter. The filter is configured to prevent egress of liquid from the multi-lumen catheter into the compartment after allowing flow of gas from the first end of the conduit through the second end of the conduit and into the multi-lumen catheter.

A method for determining the speed of sound in a fluid in the region of an implanted, vascular support system includes sending an ultrasonic signal using an ultrasonic sensor, reflecting the ultrasonic signal on at least one sound reflector, receiving the reflected ultrasonic signal, and determining the speed of sound in the fluid using the ultrasonic signal. The at least one sound reflector may be visible in the field of vision of the ultrasonic sensor and arranged at a defined distance at least to the ultrasonic sensor or to a further sound reflector.

There are provided methods and systems for training and using machine learning (ML) models to determine suitability of a given patient for an endovascular aortic repair (EVAR) intervention and to monitor the given patient after the EVAR intervention. The pre-EVAR ML models are trained on training datasets comprising strain maps having been generated based on a multiphase image stack of the aorta of each respective patient during a cardiac cycle, measures of aortic weakness in the aorta of each respective patient, geometric features of the aorta of the respective patient, and outcomes of the EVAR intervention on the respective patient. The post-EVAR ML models are trained on pre-EVAR strain maps, post-EVAR strain maps having been generated after the EVAR intervention, and a respective outcome of the EVAR intervention.

The invention discloses a test system and method for an artificial heart valve implant, and relates to the technical field of medical instrument detection. The system comprises a ventricle simulator, an atrium simulator, a circulation loop, a high-speed camera and a laser generator, wherein an artificial heart valve is arranged in the high-transparency compliance valve testing cavity, and the circulation loop is composed of a blood vessel compliance simulator and a blood vessel damping simulator. The circulation loop simulates a blood flowing environment for the artificial heart valve, and a flowing medium is added with tracer particle turbid liquid; the ventricle simulator, the atrium simulator, the vascular damper and the vascular compliance simulator respectively provide power, storage space, resistance and pulse pressure for the flowing medium; and the laser generator and the high-speed camera act together to obtain a particle image behind the artificial heart valve. The particle image is uploaded to a computer for heart valve pulsating flow field visualization analysis based on the digital particle image velocity measurement technology, and therefore quantitative analysis of the risk after the heart valve is implanted into the expected position is achieved.

Systems and methods for cooling a biological sample with different temperature cooling blocks. Warmer cooling blocks can be placed around a container and cooler cooling blocks can be placed above the container. The biological sample can be a pancreas, heart or other organs. The method and system can rely on convection, or gravity-based fluid movement, to make the temperature within the container consistent.

The dynamic monitoring system for the senile cardiac patient comprises a multi-mode sensor module, a data processing module, an analysis module and an alarm module. The multi-modal sensor module collects parameters to generate a multi-modal physiological signal; the data processing module generates a preprocessing signal; the analysis module performs real-time analysis on the pre-processed signal based on a preset elderly electrocardiogram characteristic model to generate a graded alarm instruction; the alarm module triggers corresponding local reminding, remote notification or first-aid linkage response according to the graded alarm instruction, wherein the first-aid linkage response automatically sends the patient position and key physiological data to a specified first-aid center through the first-aid communication module; wherein the self-adaptive adjustment of the multi-mode sensor module comprises the step of dynamically optimizing signal gain according to a skin contact state. According to the dynamic monitoring system for the senile cardiac patients, the problems that dynamic monitoring of the senile cardiac patients is poor in real-time performance, high in false alarm rate and delayed in first-aid response can be solved.

In one embodiment, a medical system includes a catheter configured to be inserted into a chamber of a heart of a living subject, and including multiple electrodes configured to capture electrical activity from electrical activation signals propagating in tissue of the chamber, a display, and processing circuitry configured to automatically select bipolar signals to be captured into an electro-anatomical map from respective electrode pairs of the multiple electrodes responsively to an alignment of the respective electrode pairs with a direction of propagation of the electrical activation signals, and render the electro-anatomical map to the display.

The present invention provides a prosthetic heart valve device with improved fit and / or apposition between the device frame and left atrial tissue and / or the device base and the annular tissue of the left atrium to improve shifting of the implanted device and / or mitigate paravalvular leakage. The improved fit and / or apposition arises in various embodiments by providing or allowing an asymmetrical frame and / or frame base and / or providing a lower lip to aid in conforming to the asymmetrical shape of the atrium and / or ensure firm positioning therein. An additional benefit of these arrangement(s) is mitigation of paravalvular leakage as a result of improved fit and seal. In certain embodiments, the asymmetry of the frame assists with delivery of the device into the atrium.

Various systems, devices, and methods are disclosed herein for treating acute myocardial infarction (AMI) patients using a heart pump controlled in a manner that maximizes mechanical unloading of the left ventricle in the presence of cardiovascular instability and minimizes myocardial oxygen consumption (MVO2) and consequentially infarct size to prevent the development of subsequent heart failure. In a closed feedback system, the system can include a sensor configured to generate an output used to measure or calculate a left ventricular systolic pressure (LSVP) within the left ventricle of a heart and a controller coupled to a heart pump. The controller can be configured to measure or calculate the LVSP based on the output of the sensor and to control an operation of the heart pump to maximize mechanical unloading of the left ventricle based on the measured or calculated LVSP.

The invention relates to a method for determining at least a flow velocity or a fluid volume flow (5) of a fluid flowing through an implanted vascular support system (1), comprising the following steps: a) carrying out a pulsed Doppler measurement by means of an ultrasonic sensor (2) of the support system (1), b) evaluating a measurement result from step a), which has a possible ambiguity, c) providing at least one operating parameter of a flow machine (3) of the support system (1), d) determining at least the flow velocity or the fluid volume flow (5) using the measurement result evaluated in step b), wherein the possible ambiguity of the measurement result is corrected using the operating parameter.

The invention provides a heart multi-mode digital twinning simulation method and system, electronic equipment and a medium, and belongs to the technical field of digital twinning. The method comprises the following steps: S1, collecting multi-modal data of a heart; s2, preprocessing the acquired multi-modal data to obtain heart digital data; s3, based on the heart digital data, constructing a multi-modal digital twinborn model of the heart and optimizing the multi-modal digital twinborn model; s4, performing real-time simulation on the electrophysiological activity of the heart by using the optimized multi-modal digital twin model and using a Runge-Kutta method in combination with a PSO (Particle Swarm Optimization) algorithm; s5, based on the optimized multi-mode digital twinborn model and the simulation result, simulation and planning of virtual cardiac surgical treatment are carried out; and S6, dynamically evaluating the multi-modal digital twin model, and monitoring the state change of the heart in real time. According to the heart multi-mode digital twinborn simulation method and system, the electronic equipment and the medium, efficient simulation and real-time monitoring of the heart state can be achieved.

Methods and corresponding systems of identifying coronary artery disease. The methods comprises receiving contrast cardiac CT data indicative of a contrast cardiac CT scan carried out on a patient, and analysing the contrast cardiac CT data using machine learning to identify a plurality of seed points in the contrast cardiac CT data expected to correspond to locations in cardiac arteries of the patient. The methods also comprise producing data indicative of transverse image slices of the cardiac arteries of the patient using the contrast cardiac CT data and the identified seed points, analysing the transverse image slice data using machine learning to produce inner artery wall data and outer artery wall data indicative of predicted respective inner and outer walls of the coronary arteries of the patient, and identifying presence of coronary artery disease using the predicted inner and / or outer walls of the coronary arteries of the patient.

To provide a device assembly and a method for treating heart failure by normalizing an elevated blood pressure in the left atrium of the heart of a mammal.SOLUTION: Disclosed herein is a transcatheter interatrial septum excision device assembly configured to create a sized interatrial aperture between right and left atria of a heart for relief of an elevated left atrial pressure. The device assembly comprises a delivery catheter, a tissue stabilizer attached to a first catheter having a central lumen and a penetrating tip that permits passage of a guidewire, and a cutter attached to a second catheter having a central lumen that permits passage of the first catheter. Alternative configurations comprise a (third) catheter having a central lumen that permits passage of the components to and from the right atrium, a tissue retention mechanism, and an optional coaxial alignment mechanism.SELECTED DRAWING: Figure 1

An intravascular heart pump assembly can include a rotor with at least one impeller blade, and a cannula. The present application describes various cannulas that can be manufactured from multiple layers of material to improve flexibility, manufacturability, and durability without increasing an outer diameter of the cannula. In one embodiment, the cannula includes an inflow section having a sheet formed of a shape memory material embedded within a polymer and having at least one lateral hole or aperture in the inflow section. The at least one lateral hole is defined by a first hole in the sheet and a second hole in the outer polymer layer of the cannula. The first hole and the second hole overlap so that blood can enter the cannula through the holes.

A prosthetic heart valve may include a balloon-expandable frame extending between an inflow end and an outflow end, a plurality of prosthetic leaflets mounted within the frame, and an inner skirt positioned between the plurality of prosthetic leaflets and the frame. The frame may include a first row of diamond-shaped cells at the inflow end of the frame, a second row of diamond-shaped cells, and a row of outflow cells positioned at the outflow end of the frame. Each cell in the row of outflow cells may not be diamond-shaped, and, in an expanded condition of the frame, each cell in the row of outflow cells may have a larger area than that of each cell in the first and second rows of diamond-shaped cells. Each outflow cell may be at least partially defined by a commissure attachment feature, and each outflow cell may lack symmetry.

The systems, devices, and methods presented herein use a blood pump to obtain measurements of cardiac function. The system can quantify the functioning of the native heart by measuring certain parameters / signals such as aortic pressure or motor current, then calculate and display one or more cardiac parameters and heart function parameters, such as left ventricular pressure, left ventricular end diastolic pressure, or cardiac power output. These parameters provide valuable information to a user regarding current cardiac function, as well as positioning and function of the blood pump. In some embodiments, the system can act as a diagnostic and therapeutic tool. Providing cardiac parameters in real-time, along with warnings about adverse effects and recommendations to support cardiac function, such as increasing or decreasing the volumetric flow rate of blood pumped by the device, administering pharmaceutical therapies, and / or repositioning the blood pump allow clinicians to better support and treat cardiovascular disease.

A transport container and methods for preserving a heart at a hypothermic temperature. The transport container can maintain the heart at a temperature of 6-8° C. for improved results after transplantation. The preservation of the heart within this range can improve transplantation outcomes.

Systems and methods for determining the positioning of intracardiac devices, such as intracardiac blood pump assemblies, using electrical sensors configured to sense electrical potential as it propagates through the heart. In one example, the present technology provides an intracardiac device with one or more electrical sensors mounted thereon, and a controller configured to determine the absolute or relative location of the intracardiac device based on the timing, shape, and / or amplitude of the electrical signals received from the one or more sensors.

A device comprises an implantable blood pump receivable in a sheath for percutaneous delivery. The implantable blood pump comprises a collapsible impeller mounted in a collapsible impeller cage, and a drive device mounted in a housing. The housing is in connection between a first end of a catheter and the collapsible impeller cage. The drive device is adapted for rotating the collapsible impeller. A retractable support structure is adapted to extend from the catheter. The extended retractable support structure is adapted to engage with the wall of the aorta for allowing the implantable blood pump to be secured in the left ventricle. The collapsible impeller cage comprises an inlet and an outlet. The inlet is adapted to receive blood from the left ventricle. The outlet directs blood in the direction of the atrioventricular valve.

The invention relates to a method for determining a flow rate of a fluid flowing through an implanted vascular assist system, said method comprising the following steps: a) carrying out a first pulsed Doppler measurement at a first pulse repetition rate by means of an ultrasonic sensor of the assist system; b) carrying out a second pulsed Doppler measurement at a second pulse repetition rate by means of the ultrasonic sensor of the assist system, wherein the second pulse repetition rate differs from the first pulse repetition rate; c) determining the flow rate using measurement results of the first pulsed Doppler measurement and the second pulsed Doppler measurement.

A collapsible and expandable prosthetic mitral valve stent is provided with improved recapture into a distal lumen of a delivery sheath. Various embodiments comprise a valve support within the interior of a stent frame and defining a flow channel therethrough, wherein the top or upstream of the valve support comprises a row, or a plurality, of stent cells that are bent radially inward at least partially over the flow channel. Some embodiments may comprise a recapture assist mechanism, such as an open paddle, attached to one or more of the inwardly bent stent cells and adapted to receive and / or engage a wire to aid in positioning, expansion, recapture and / or implanting the device in a patient's heart chamber.

The invention discloses an electrocardiogram classification system and method fusing multi-scale self-adaptive attention, and relates to the technical field of electrocardiogram classification.The electrocardiogram classification method comprises the steps that electrocardiogram data are collected through a data collection module, and a structured data set is output; the data preprocessing module is used for carrying out data preprocessing on the structured data set; the window data segmentation module obtains a standardized windowed electrocardiosignal; the feature extraction module takes the standardized windowed electrocardiosignals as input, performs three stages of multi-scale convolution feature extraction, liquid neural network dynamic modeling and self-adaptive attention mechanism enhancement, and outputs diagnosis results of nine types of heart diseases; and the training and optimizing module is used for optimizing the extraction and classification capability of the model on the electrocardiosignal features, so that the technical effects of full-process technical upgrading from data acquisition, preprocessing, feature extraction to model training optimization and high-precision electrocardiogram automatic classification are achieved.

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Prosthetic heart valves each includes a link extending along a link axis and an axial frame. The axial frame includes a plurality of struts comprising a plurality of inner struts pivotally attached to a plurality of outer struts at a plurality of pivot nodes. A first pivot node of the plurality of pivot can be attached to the link and a second pivot node of the plurality of pivot nodes can move relative to the link along the link axis. Methods of radially expanding a prosthetic heart valve can comprise radially expanding the radially expandable frame from a radially retracted orientation to a radially expanded orientation while the second pivot node axially translates relative to the link.

The invention relates to the technical field of medical image processing, in particular to an engineered heart tissue pulsation trajectory automatic analysis method based on an image recognition algorithm, which comprises the following steps: S1, multi-modal image fusion: performing space-time registration and feature fusion on acquired multi-modal heart images to generate a fused image sequence; s2, cardiac muscle tissue segmentation: outputting a cardiac muscle tissue segmentation result with a timestamp; s3, motion track modeling: generating three-dimensional track point cloud data in a pulsation period; s4, feature parameter extraction: performing spatial-temporal feature analysis on the track point cloud data, and extracting multi-dimensional motion parameters; and S5, heterogeneity atlas generation: generating a cardiac pulse heterogeneity atlas according to the multi-dimensional motion parameters. According to the method, automatic analysis of the cardiac pulse track and generation of the heterogeneity atlas based on the multi-modal image and space-time modeling are realized, and the precision and the intelligent level of cardiac motion anomaly recognition are remarkably improved.

A circulatory support device includes a flexible cannula having a fluid outlet at a proximal end, and a pump assembly disposed at a distal end of the flexible cannula. The pump assembly includes a pump housing having a fluid inlet defined therein, a motor disposed within a distal end of the housing, and an impeller, driven to rotate by the motor, and configured to push blood toward the fluid outlet. A method of deploying the device to a subject's heart using an insertion manifold that prevents a protective tube from advancing with the device into a delivery shaft, is also disclosed. Pushing the device into and then out of the shaft expands and secures a cage at a location in the vasculature.