48 results about "Vascular compliance" patented technology

An apparatus for assessing cardiovascular status of a mammal comprises a system for locally applying a pressure to an artery capable of restricting blood flow through said artery, a wideband external pulse transducer having an output and situated to measure suprasystolic signals proximate to said artery, and a computing device receiving said output for calculating vascular compliance values. The method described is particularly useful for determining cardiac output, assessing whether a pregnant female has preeclampsia or a patient has cardiac insufficiency, or assessing cardiac arrhythmias.

An apparatus for assessing cardiovascular status of a mammal comprises a system for locally applying a pressure to an artery capable of restricting blood flow through said artery, a wideband external pulse transducer having an output and situated to measure suprasystolic signals proximate to said artery, and a computing device receiving said output for calculating vascular compliance values. The method described is particularly useful for determining cardiac output, assessing whether a pregnant female has preeclampsia or a patient has cardiac insufficiency, or assessing cardiac arrhythmia.

The disclosure of the present application provides for systems and methods for determining a phasic change in a vessel and vessel compliance. In at least one exemplary method for determining a phasic change in a vessel, the method comprises the steps of introducing a device into a site within a vessel, operating the device in connection with two or more fluid injections in the vessel to obtain two or more conductance values, calculating a parallel conductance value and a total conductance value, and calculating a phasic change in at least one vessel parameter based in part upon the calculated parallel conductance value and the calculated total conductance value. In an exemplary method for determining vessel compliance, the method comprises, in part, the steps of calculating a first vessel parameter and a second vessel parameter based on at least two conductance values, calculating a change in vessel parameter based upon the first and second vessel parameters, and calculating vessel compliance based upon the relationship between the change in vessel parameter and a change in pressure during a cardiac cycle.

A non-invasive device for evaluating circulatory state parameters, and specifically, a pulsewave analysis device capable of evaluation by separating blood vessel compliance and blood vessel resistance into central and peripheral components of the arterial system is provided. Microcomputer 4 detects the waveform at a test subject's radius artery via pulsewave detector 1, and uptakes the stroke volume in the test subject which is measured by a stroke-volume measurer. Next, based on the measured stroke volume, microcomputer 4 adjusts the values of each element in a lumped five parameter model made up of an electrical circuit which models the arterial system from the center to the periphery of the body, so that the response waveform obtained when an electric signal corresponding to the pressure waveform at the proximal portion of the aorta in a test subject is provided to the electric circuit coincides with the waveform at the radius artery. Microcomputer 4 then outputs the thus-obtained values of each element as circulatory state parameters. In addition, microcomputer 4 calculates the diastolic pressure value, systolic pressure value and pulse waveform at the proximal portion of the aorta from the values of each element, and outputs the calculated result to output device 6.

A method for non-contrast enhanced 4D time resolved dynamic magnetic resonance angiography using arterial spin labeling of blood water as an endogenous tracer and a multiphase balanced steady state free precession readout is presented. Imaging can be accelerated with dynamic golden angle radial acquisitions and k-space weighted imaging contrast (KWIC) image reconstruction and it can be used with parallel imaging techniques. Quantitative tracer kinetic models can be formed allowing cerebral blood volume, cerebral blood flow and mean transit time to be estimated. Vascular compliance can also be assessed using 4D dMRA by synchronizing dMRA acquisitions with the systolic and diastolic phases of the cardiac cycle.

Impedance devices and methods of using the same in connection with a mammalian vasculature. In an embodiment of a method for determining vessel compliance, the method comprises the steps of introducing at least part of an impedance device into a site within a vessel, the impedance device comprising an elongated body having a distal body end, and a first electrode located along the elongated body at or near the distal body end, providing electrical current to the first electrode and a first external electrode not coupled to the elongated body to generate the electric field, the first external electrode positioned upon or within a mammalian body having the vessel therein, operating the impedance device to obtain two or more conductance values within the electric field, and calculating vessel compliance based upon the relationship between a change in vessel parameter and a change in pressure during a cardiac cycle.

The present invention relates to a device, system and method for monitoring of peripheral arterial perfusion of a subject. To enable distinguishing between low pulsatility caused by centralization or low cardiac output, the proposed device comprises an input (30) for receiving first detection data of a tissue region of a subject, said first detection data being acquired over time by detecting radiation reflected from and / or transmitted through tissue of the subject, and for receiving second detection data of a skin region of subject, said second detection data being acquired over time by detecting radiation received from said tissue region in response to coherent light being emitted towards said skin region, a PPG unit (32) for deriving a photoplethysmography, PPG, signal from said first detection data, a flow unit (34) for deriving, from said second detection data, a flow signal indicative of a flow of light scattering particles within the skin region, and an evaluation unit (36) for evaluating said PPG signal and said flow signal to obtain information on the peripheral arterial perfusion, wherein the evaluation unit is adapted to determine a state of low vascular compliance and / or a state of low cardiac output based on a combined evaluation of said PPG signal and said flow signal.

A non-invasive device for evaluating circulatory state parameters, and specifically, a pulsewave analysis device capable of evaluation by separating blood vessel compliance and blood vessel resistance into central and peripheral components of the arterial system is provided. Microcomputer 4 detects the waveform at a test subject's radius artery via pulsewave detector 1, and uptakes the stroke volume in the test subject which is measured by a stroke-volume measurer. Next, based on the measured stroke volume, microcomputer 4 adjusts the values of each element in a lumped five parameter model made up of an electrical circuit which models the arterial system from the center to the periphery of the body, so that the response waveform obtained when an electric signal corresponding to the pressure waveform at the proximal portion of the aorta in a test subject is provided to the electric circuit coincides with the waveform at the radius artery. Microcomputer 4 then outputs the thus-obtained values of each element as circulatory state parameters. In addition, microcomputer 4 calculates the diastolic pressure value, systolic pressure value and pulse waveform at the proximal portion of the aorta from the values of each element, and outputs the calculated result to output device 6.

The invention relates to a method for extracting two-dimensional dynamic blood vessel information based on ultrasonic echo in real time, which comprises the following steps: forming and displaying a blood vessel indication cursor on an ultrasonic two-dimensional image; conducting extraction on the information about the blood vessel diameter for the original blood vessel digital radio frequency echo data to obtain the blood vessel diameter data and the blood vessel diameter variation data, wherein the representation unit of the diameter information is the number of sampling points; determining the actual diameter and fluctuations of the blood vessel according to the blood vessel indication cursor and the information about the blood vessel diameter; and further calculating blood flow volume, the fluctuation range and characteristic points of the blood vessel as well as blood flow diameter arc graphs according to the blood vessel diameter information of the blood vessel diameter variation information by combining other existing information, namely electrocardiogram information and blood flow frequency spectrogram, thus obtaining real-time two-dimensional dynamic blood vessel information. According to the invention, an analysis tool is provided for dynamic assessment of blood flow / blood vessel and compliance / elastic analysis of the blood vessel, pressure signals in the axial and radial directions of the blood vessel are provided for pulse condition analysis and research, and the extraction method has the characteristics of practical applicability and clinical practice.

The invention belongs to the technical field of medical biomaterial property test, and particularly relates to a biomechanical property testing device and a testing method for blood vessel prosthesis. The testing device includes a liquid storage box, a current guide silicon tube, an electronic peristaltic pump, a current limit switch, a conducting wire, a computer mounted with signal processing and converting software and data output equipment as well as a sample fixing device, a pressure testing device and a displacement testing device. By utilizing the device, the relation curve of the pressure and the tube diameter is measured and recorded in real time, so that the detecting results of compliance, fatigue resistance and bursting pressure are calculated and obtained, and the biomechanical properties of the blood vessel prosthesis are scientifically tested and evaluated; therefore, the technical problem of testing the biomechanical properties of the integral blood vessel prosthesis under the existing physiological status is solved, the integral testing and evaluation of the compliance, the fatigue resistance and the bursting pressure of the blood vessel prosthesis are realized, and scientific and reliable evidences are provided for choosing the blood vessel prosthesis with the biomechanical properties meeting the requirements.

An apparatus for assessing cardiovascular status of a mammal comprises a system for locally applying a pressure to an artery capable of restricting blood flow through said artery, a wideband external pulse transducer having an output and situated to measure suprasystolic signals proximate to said artery, and a computing device receiving said output for calculating vascular compliance values. The method described is particularly useful for determining cardiac output, assessing whether a pregnant female has preeclampsia or a patient has cardiac insufficiency, or assessing cardiac arrhythmia.

A system for detecting and measuring increased global or local intracranial pressure includes various devices for performing controlled occlusion of jugular cranial blood outflow and generating occlusion data related to said controlled occlusion, a cranial blood outflow pressure measurement device and a processor for processing jugular cranial blood outflow occlusion data and cranial blood outflow data to identify and / or measure a functional relationship between the jugular controlled occlusion and the jugular cranial blood outflow pressure. A device communicates the functional relationship a display device and / or a patient monitoring system. The processor also detects a state of equilibrium between the jugular cranial blood outflow pressure and the jugular occlusion pressure at occlusion. In yet another embodiment, intracranial and extracranial vessel compliance is measured by NIRS system, the equilibrated using external compression bladder, and equilibrium bladder pressure is displayed as local intracranial pressure.

The disclosure of the present application provides for systems and methods for determining a phasic change in a vessel and vessel compliance. In at least one exemplary method for determining a phasic change in a vessel, the method comprises the steps of introducing a device into a site within a vessel, operating the device in connection with two or more fluid injections in the vessel to obtain two or more conductance values, calculating a parallel conductance value and a total conductance value, and calculating a phasic change in at least one vessel parameter based in part upon the calculated parallel conductance value and the calculated total conductance value. In an exemplary method for determining vessel compliance, the method comprises, in part, the steps of calculating a first vessel parameter and a second vessel parameter based on at least two conductance values, calculating a change in vessel parameter based upon the first and second vessel parameters, and calculating vessel compliance based upon the relationship between the change in vessel parameter and a change in pressure during a cardiac cycle.

The present invention relates to a cardiovascular diagnostic system which enables early detection of cardiovascular diseases and defines their causes. Unlike known electrocardiographs, the cardiovascular diagnosis system can further measure elastic coefficient of blood vessels (the degree of arteriosclerosis), blood vessel compliance, blood flow, and blood flow resistance and velocity in blood vessel branches of the right and left coronary arteries. The elastic coefficient shows organic changes to blood vessels. The compliance shows organic and functional changes of blood vessels simultaneously. The blood flow shows blood flow resistance.

A method and compositions for regulating bone density and / or circulating lipid levels in a subject based on the combined administration of at least one isoflavone or functional derivative, equivalent or analogue thereof and at least one lipid regulating drug. The method and compositions are applicable to the beneficial alteration of blood lipoprotein levels, the improvement of vascular compliance, the decrease in the propensity of thrombogenic events, the reduction in the risk of vascular disease, coronary heart disease, and arteriosclerosis, and to the treatment or prevention of osteoporosis.

The present invention relates to a blood vessel support. It is made up by using elastic metal tube material through an engraving process. Said support includes several net-rings which are arranged along axial direction and formed from elliptic basic units. After having been expanded said blood vessel support not only can retain higher radial supporting force, but also has good axial flexibility and blood vessel compliance.

The present invention relates to a health-care grape beverage. It is characterized by that the vitamins of B family with effective dose can be added into the beverage made up by using grape as main raw material. Said health-care grape beverage can be used for protecting cardio vascular and cerebrovascular function, and can be used for preventing angiocardiopathy and cerebrovascular disease.

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises epimedium extract, hooked uncaria extract and puerarin by the weight ratio of 20-500 : 3-80 : 40-1000. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms including injections, tablets, capsules, soft capsules, dripping pills, oral liquids, and granules. The composition can be used for treating hypertension, cephalalgia, nervous prostration and cardiovascular and cerebrovascular diseases.

A braided vascular scaffold with external netted skirt ring layer is made up of elastic metal wire through braiding, and is composed of a netted tubular main body and at least one external netted skirt ring layer, which have multiple deformable units and multiple arc wires at both ends. It can not be moved by blood stream and has high radical supporting power, flexibility and vascular compliance.

The present invention relates to a cerebrovascular analysis system which enables early diagnosis of various incurable cerebrovascular diseases such as cerebral thrombosis by measuring an elastic coefficient, blood vessel compliance, blood flow resistance, and blood flow in each cerebrovascular branch. The measurement is achieved by biomechanically analyzing blood vessels in the brain using an electrocardiogram, phonocardiogram, electroencephalogram, pulse wave, and ultrasonic doppler signal as basic data in order to measure biomechanical properties and blood flow properties of blood vessels in the brain for the diagnosis of cerebrovascular diseases.

The present invention provides a blood vessel support. Said support is made up by engraving an elastic metal tube material, it includes several net rings which are arranged along axial direction and are formed from prismatic basic units, between every two adjacent net rings they are connected by means of several Y-shaped connecting pieces.

A method for measuring blood pressure, pulse and vascular compliance without invading a vascular cavity is provided. The blood flow of a vessel is blocked by using an artery clamp, a voltage-variable resistor-containing probe of a pressure transducer is implanted between the muscle layer and the inner membrane of the vessel at the distal end to the heart, followed by biogum sealing; or the voltage-variable resistor probe is closely attached to the outer membrane of the vessel, and then the probe and the vessel are fixed together inside a rigid cylindrical cover. When the artery clamp is released, the pressure inside the vascular cavity rises and is transferred to the voltage-variable resistor probe, resulting in the change in resistance, the resistance change is converted into a current change that is processed by a computer to produce a continuously-recorded blood pressure change, and simultaneously the computer calculates pulses according to the peak distance of the blood pressure and records the change in pulse. The cylindrical cover is provided thereon with a tension transducer that converts a change of vessel displacement into a change of resistance and then a change of vessel displacement again, representative of the change in vascular volume, and calculates continuously-varying vascular compliance. The invention doesn't block the blood flow at the distal end of the vessel to avoid the influence on blood supply to the dominant organs of the vessel to be detected.

A method for measuring the pulse pressure of two adjacent points and its device are disclosed. This method includes such steps as arranging two pressure sensors on a upstream point and a downstream point of the same blood vessel at a spacing of distance long the blood flow direction, measuring their pulse pressures and waveform variation, detecting the delay time of pulse wave between them by a delay detecting circuit, measuring the upstream pulse pressure, and calculating the downstream pulse pressure.

The present invention provides a tube-net type blood vessel support. It is made up by using metal tube through an engraving process, and includes several ring supporting bodies which are identical in structure and arranged along axial direction. After having been expanded said blood vessel support not only can retain higher radial supporting force, but also has good axial flexibility and blood vessel compliance.

A braided vascular scaffold with external tongue structure layer is made up of elastic metal wire through braiding, and is composed of a netted tubular main body and at least one external tongue structure. Said main body has multiple deformable units and multiple arc wires at both ends. It can not be moved by blood stream and has high radical supporting power, flexibility and vascular compliance.

The invention discloses a method for measuring arteriosclerosis of 4D time-resolved dynamic magnetic resonance imaging without injecting contrast agent, which is based on the current clinical demand and combines the non-invasive application of magnetic resonance angiography technology at present. By using dynamic magnetic resonance angiography (dMRA) technique synchronized with the cardiac cycle,changes in arterial blood flow at the peak of systole and early diastole are obtained, and changes in arterial blood pressure are measured, and the ratio of intracranial vascular compliance is definedby the ratio (Vascular Compliance), quantitative information about arteriosclerosis can be obtained and used for the evaluation of intracranial arteriosclerosis.

The invention relates to an artificial blood vessel structure capable of improving compliance, belonging to the field of medical instruments. The woven structure is characterized in that it is a polyester artificial blood vessel, the inner and outer layers of the polyester artificial blood vessel are woven with a satin structure, the warp yarn is made of PET textured yarn, the middle layer of thepolyester artificial blood vessel is woven plain weave, and the warp yarn is made of PET filament. In the inner and outer layers of the polyester artificial blood vessel, the weft yarn is a compositeyarn composed of a textured yarn or an elastic yarn or a non-elastic yarn. Compared with the prior art, the invention has the beneficial effects that the artificial blood vessel of the invention adopts the composite yarn composed of the textured yarn or the elastic yarn and the inelastic yarn, so that the radial diameter of the blood vessel can meet the requirements of the human body, and the compliance of the blood vessel is improved by 3% to 5%.

Pulsatile balloon catheter systems are provided. Aspects of the systems include: a pulse generator; and a balloon catheter assembly operably connected to the pulse generator. In embodiments, the balloon catheter assembly includes: a proximal connector operably connecting the balloon catheter assembly to the pulse generator and configured to transduce a first pulse energy generated by the pulse generator to a second pulse energy; a distal balloon; and a catheter component, where the catheter component includes a fluidic passage operably positioned between the proximal connector and the distal balloon, which passage is configured to propagate the second pulse energy from the proximal connector along the fluid passage to the distal balloon. Also provided are balloon catheter assemblies and kits that include the same. Also provided are systems and methods for assessing vessel compliance in-vivo. Also provided are systems and methods for determining system state of balloon catheter systems. The systems, assemblies and kits find use in a variety of different applications, including balloon angioplasty applications.