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Medicine composition containing epimedium extract, uncaria extract, and gastrodine, and its preparation and use

A kind of epimedium extract, Uncaria extract technology, applied in the field of medicine

Active Publication Date: 2007-03-07
BEIJING SIHUAN PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Using the interaction of Epimedium or its extract, Uncaria or its extract, and Gastrodin, the compatibility of the three drugs is used to prepare and improve vascular compliance and hemodynamics, treat hypertension, headache, neurasthenia, and regulate Drugs for immunity, anti-cardiovascular and cerebrovascular diseases, etc. have not been reported yet

Method used

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  • Medicine composition containing epimedium extract, uncaria extract, and gastrodine, and its preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0142] Example 1 Preparation, Identification and Content Determination of Epimedium Extract

[0143] Take Epimedium medicinal material, cut into small pieces, add water to decoct twice, each time for 1.5 hours, each time add water to 10 times the amount. Combine the decoctions, put them in cold storage overnight, filter, concentrate the filtrate to a concentrated solution with a relative density of 1.08 to 1.10, add it to the treated polyamide resin column, wash it with 3 to 4 times the column volume of water, and then wash it with 2 Rinse with 20% ethanol for ~3 times the column volume, discard the washing solution, and then elute with 95% ethanol for 4 to 5 times the column volume, collect the eluate, recover the ethanol, and spray dry to obtain the product.

[0144] Prepare three batches respectively, and according to Test example 2 and Test example 3 The methods under this item were used for identification and content determination, and the results are shown in Table ...

Embodiment 2

[0146] Example 2 Preparation, Identification and Content Determination of Uncaria Extract

[0147] Take 1000g of Uncaria uncaria, crush it into a coarse powder, add 70% ethanol to reflux and extract twice, each time for 2 hours, and add alcohol to 10L each time, combine the extracts, filter, recover the ethanol until it has no alcohol smell, add water to an appropriate amount (per 1ml is equivalent to 2g of the original medicinal material). Stir well, add concentrated hydrochloric acid to adjust the pH value to 1-2, refrigerate for 4 hours, filter, add petroleum ether to the filtrate and shake and extract once, discard the petroleum ether solution, add 10% sodium hydroxide to the acid water solution to adjust the pH value to 9-10, refrigerate overnight, filter the precipitate, add 1mol / l dilute hydrochloric acid to dissolve, refrigerate for 4 hours, filter, add 10% sodium hydroxide to the filtrate to adjust the pH value to 9-10, and refrigerate Overnight, the precipitate was ...

Embodiment 3

[0307] The preparation technology of embodiment 3 YGT sodium chloride injection

[0308] 1. Prescription:

[0309] Epimedium Extract 100g

[0310] Uncaria Extract 16g

[0311] Gastrodin 200g

[0312] Sodium chloride 900g

[0313] Add water for injection to 100000ml

[0314] A total of 1000 bottles were prepared

[0315] 2. Specific steps:

[0316] (1) Dispose of the pipes and containers used for liquid preparation the day before, and rinse them with fresh water for injection before use;

[0317] (2) Add epimedium extract, Uncaria extract, and gastrodin into water for injection with 40% dosing volume, heat and stir to dissolve completely, and dissolve sodium chloride completely with water for injection with 20% dosing volume;

[0318] (3) Combine the two solutions and add water for injection to the full amount;

[0319] (4) Add activated carbon for needles with a dosing volume of 0.1%, heat and stir for 15 minutes;

[0320] (5) Decarburization by sand filter rod filtra...

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Abstract

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises epimedium extract, hooked uncaria extract and puerarin by the weight ratio of 20-500 : 3-80 : 40-1000. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms including injections, tablets, capsules, soft capsules, dripping pills, oral liquids, and granules. The composition can be used for treating hypertension, cephalalgia, nervous prostration and cardiovascular and cerebrovascular diseases.

Description

1. Technical field [0001] The invention relates to a pharmaceutical composition composed of epimedium extract, uncaria extract and gastrodin, its preparation method and application, and belongs to the technical field of medicine. 2. Background technology [0002] Epimedium is Berberidaceae plants Epimedium brevicornum Maxin., Epimedium sagittatum Maxin., Epimedium pubescens Maxin., Epimedium wushanense T.S.Ying ) or the dry aerial part of Epimedium koreanum Nakai. The use of epimedium in medicine began in "Shen Nong's Materia Medica", and "Compendium of Materia Medica" stated that it has the effect of "benefiting essence, strengthening bones, waist and knees, and strengthening heart". Modern pharmacological research shows that Epimedium can increase the blood flow of cardiovascular and cerebrovascular, promote hematopoietic function, immune function and bone metabolism, and has anti-aging and anti-tumor effects. [0003] Epimedium extract is an extract obtained by extracti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/74A61P9/12A61P9/00A61P37/02A61P25/20A61K31/7034
Inventor 蔡军
Owner BEIJING SIHUAN PHARMA
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