59 results about "Gastrodine" patented technology

The invention relates to a method for preparing gastrodine, which has simple operation, light pollution and little equipment input. The method has the following process steps: taking coarse gastrodine powder; adding 60 to 90 percent ethanol into the coarse powder for percolation; collecting percolate of which the volume is 5 to 10 times the weight of a medical material; filtering, and reclaiming the ethanol at reduced pressure; condensing the percolate to dryness; adding methanol into residue for dissolution; injecting the solution into a high-efficient countercurrent extractor; using a lower phase of a water-methanol-acetic ether (1:1:8) solvent system as a stationary phase and an upper phase as a mobile phase, and collecting and condensing a gastrodine section; precipitating and separating crystal; and adding methanol-acetic ether (1:5-10) into the crystal for recrystallization. The gastrodine prepared by the method has high purity and is easy to realize industrialized amplification.

The invention provides a novel method for simultaneously extracting gastrodia elata polysaccharide and gastrodine, relating to the technical field of processing of subsidiary agricultural products. The method is characterized by comprising the following steps: pulverizing dry gastrodia elata, carrying out water extraction and alcohol precipitation, washing the precipitate with alcohol, drying under reduced pressure, pulverizing to obtain gastrodia elata polysaccharide, and concentrating the alcohol filtrate under reduced pressure to obtain gastrodine extractum. The invention has the characteristics of simple technique, high utilization ratio of raw materials, low solvent consumption, low cost, high extraction rate, good economic benefits, no environmental pollution and the like, and the production is free from the influence of the gastrodia elata production seasons.

The invention discloses glycosyl transferase synthesized by catalytic gastrodine as well as a gene of encoding enzyme and application. The glycosyl transferase synthesized by catalytic gastrodine is shown in SEQ ID No:1; another glycosyl transferase synthesized by catalytic gastrodine is shown in SEQ ID No:2. According to the glycosyl transferase synthesized by two catalytic gastrodine, p-hydroxybenzyl alcohol can be catalyzed and converted into gastrodine, so that the yield of gastrodine can be obviously improved.

The present invention relates to one kind of Chinese medicine film preparation capable of dissolving in oral cavity fast. The film preparation consists of active Chinese medicine component(s) in 0.1-99 wt%, filming material in 0.1-90 wt% and medicinal supplementary material in 0-30 wt%. The active Chinese medicine components includes red sage extract, total arasaponin, breviscapine, gastrodine, acetyl gastrodine, etc. The Chinese medicine film preparation has convenient taking, fast absorption, high bioavailability, less irritation to digestive tract mucous membrane and other advantages, and is especially suitable for use in treating acute cardiac and cerebral vascular diseases and migraine.

The present invention discloses microbe cell synthesis process of converting p-hydroxy benzyl alcohol to synthesize gastrodine. The process is one converting reaction of wet cell of rmillaria luteo-virens ZJUQH in 1-10 g / 100ml and 0.22 micron microporous film filtered p-hydroxy benzyl alcohol in 0.1-3.1 mmol / L, in the culture liquid comprising sterilized potato in 2 wt% concentration and glucose in 0.5 concentration, at temperature of 20-25 deg.c and shaking table rotation speed of 50-200 rpm for 1-3 days. Compared with available plant cell conversion process, the microbe cell synthesis process has the advantages of short period, simple operation and easy control.

The invention provides a gastrodine injection, which comprises the forms of gastrodine water for injection and metal chelating agent, the invention also discloses its preparation and use. Wherein the preparation comprises depositing gastrodine with water, cold storing, ultrafiltration technology processing, and sterilizing. The injection can be used for treating brain trauma, megrims, nerve pain, cephalodynia and neurasthenia.

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises epimedium extract, hooked uncaria extract and puerarin by the weight ratio of 20-500 : 3-80 : 40-1000. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms including injections, tablets, capsules, soft capsules, dripping pills, oral liquids, and granules. The composition can be used for treating hypertension, cephalalgia, nervous prostration and cardiovascular and cerebrovascular diseases.

The present inventino discloses a method for determining gastrodine content. It adopts the following method to prepare test sample solution: precisely weighing gastrodia root powder dried to constant weight, placing it in graduated flask, calibrating weight, precisely adding methyl alcohol whose concentration is 20%-90% and added quantity is 20-40 times gastrodia root powder weight, making ultrasonic treatment for 15-120 min, standing still for 0-24 hr., secondary ultrasonic treatment for 0-120 min, more calibrating weight, using methyl alcohol whose concentration is 20%-90% of supplement reduced weight, uniformly shaking them, standing still, taking supernatant fluid and centrifuging so as to obtain the invented test sample solution.

A slow-releasing gastrodine and its preparing process are disclosed.

The invention relates to a gastrodine compound and a pharmaceutical composition thereof. The gastrodine compound is a crystal. The X-ray powder diffraction determines that the characteristic peaks are displayed when 2theta+ / -0.2 degree is 4.5 degrees, 5.7 degrees, 7.9 degrees, 10.3 degrees, 11.2 degrees, 13.0 degrees, 16.4 degrees, 19.6 degrees, 21.2 degrees, 22.7 degrees, 24.8 degrees, 26.7 degrees, 29.6 degrees, 34.1 degrees and 35.3 degrees. The gastrodine compound has very high stability, thereby greatly enhancing the medicine safety. The invention also relates to a pharmaceutical composition preparation containing the gastrodine compound. The composition preparation can be a freeze-dried powder injection, injection, tablet or capsule. The gastrodine freeze-dried powder injection, injection, tablet or capsule preparation provided by the invention has the advantages of simple prescription technique, obviously higher stability, and enhances the medicine safety and effectiveness.

The invention discloses oral liquid of grey polypore which is rich in gastrodine and organic selenium and a process for preparation. Fresh gastrodia elata and bitter garlic are pre-processed, dried, and grinded by the invention, which take deep fermentation with grey polypore in powder shape to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium. The process for preparation comprises first, culturing bacterial of a slant face of the grey polypore, second, culturing liquid seed, third, processing raw material which are gastrodia elata and bitter garlic, fourth, fermenting, fifth, post-treating products. In the oral liquid of the invention, the content of gastrodine is 2.2 to 2.8mg / 100ml, the content of crude polysaccharide is 4.0 to 4.8mg / L, and the content of organic selenium is 0.11*10-6 to 0.21*10-6. Compared with the prior art, the oral liquid of the invention can play a stronger effect of anti-tumor and enhance human immunity, and inhibit and kill cancer cells without hurting normal cells of human bodies simultaneously, which can service for human health. The process of the invention can lead gastrodine, bitter garlic, and grey polypore to be fermented together to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium, and the oral solution can be produced in large scale.

The present invention discloses microbe cell synthesis process of converting p-hydroxy benzyl alcohol to synthesize gastrodine. The process is one converting reaction of wet cell of rmillaria luteo-virens ZJUQH in 1-10 g / 100ml and 0.22 micron microporous film filtered p-hydroxy benzyl alcohol in 0.1-3.1 mmol / L, in the culture liquid comprising sterilized potato in 2 wt% concentration and glucose in 0.5 concentration, at temperature of 20-25 deg.c and shaking table rotation speed of 50-200 rpm for 1-3 days. Compared with available plant cell conversion process, the microbe cell synthesis process has the advantages of short period, simple operation and easy control.

The invention discloses a method for determining gastrodine content in gastrodia elata, which comprises the following steps: 1. pulverizing gastrodia elata, and mixing with diatomite, wherein the weight ratio of the gastrodia elata to the diatomite is 1:1, and the pulverized gastrodia elata is the gastrodia elata powder screened through a 50-mesh sieve; 2. extracting gastrodine by an ASE (accelerated solvent extraction) extraction process, and collecting the extracting solution, wherein the extraction solvent adopted by the ASE extraction process is a 49.5-50.5 vol% dilute ethanol solution; 3. drying the extracting solution by distillation, dissolving in an acetonitrile-0.05% phosphoric acid water solution mixture, diluting to the specific volume, centrifugating, and taking the supernate; and 4. determining the gastrodine content in the supernate by high-performance liquid chromatography. The invention aims to provide a method for determining gastrodine content in gastrodia elata, which has the advantages of high extraction speed and high measurement accuracy.

A pure-component Chinese medicinal preparation for treating headache and its preparation process, using Gastrodia elata and Ligusticum chuanxiong as basic formulation, adopting modern flash extraction technique, combining macroporous resin, normal / reversed-phase silica gel chromatography technique and high-speed counter-current chromatography preparation technique, extracting a volatile oil fraction containing butylphthalide as main component, an alkaloid fraction containing ligustrazine as main component, an organic acid fraction containing ferulic acid as main component, a lactone fraction containing ligustilide as main component, a phenols fraction containing gastrodine as main component and a polysaccharide fraction containing polysaccharides from Ligusticum chuanxiong as main component. The Chinese medicinal preparation provided by the invention has definite curative effect, definite composition, controllable quality, and simple operation method.

An oral disintegrating tablet of acegastrodine for treating insomnia and nervous headache is prepared from acegastrodine, souring agent, excipient, and disintegrant.

A low-capacity intravenous injection of gastrodine for treating neurasthenia, neurasthenia syndrome, cerebral trauma syndrome, dizziness, Meniere's disease, reuralgia, headache, etc is prepared from gastrodine, the water for injection and metallic chelating agent. Its preparing process is also disclosed.

The invention discloses a gastrodine nasal administer drug agent to treat nervous prostration and vascular dementia, which is characterized by the following: adopting gastrodine as main raw material and certain effective drug as auxiliary material; resisting pain; modifying local brain blood flow; targeting brain through gastrodine.

The invention discloses C-glycoside with substituted aromatic ring, S-glycoside compounds, pharmaceutical compositions with effective dose compounds, and applications of the compounds and compositions for preparing cardio-cerebrovascular anti-hypoxic ischemia medicine and neuroprotection medicine. In the compounds are c-glycoside compounds when X represents CH2, wherein when Y represents CH2, n may be 0 or 1, when n is 0, m is 0, and when n is 1, m is 0 or 1; when Y represents NH, n=m=1; when X represents S, the compounds is S-glycoside compounds, wherein Y represents CH2, n may be 1, 2 or 3, and m is 0; R represents mono-substituted, disubstituted, tri-substituted hydrogen C1-C3 straight-chain or branched chain alkyl and hydroxyl, or C1-C3 straight-chain or carboxylic acid ester. 14 compounds found have better protective action to hypoxia-reoxygenation injury of myocardium than or equal to salidroside; 15 compounds have stronger neuroprotection activity than or equal to gastrodine.

The present invention relates to a gastrodin effervescent tablet which is assuasive and is used for remedying the insomnia and the cardiovascular neurogenic headache and a preparation method thereof. The present invention aims at providing the wide patient and the medical worker with a new preparation gastrodin effervescent tablet which is disintegrated and absorbed fast, has high bioavailability, is convenient for being taken with less intestinal residues and less side effect. Gastrodin is taken as the raw material, and the specific sorts of accessories in proportion are added. The gastrodin effervescent tablet is prepared by the technical measurement provided by the present invention, and a product of the present invention has sweet flavor with fragrance, takes effect fast, has high bioavailability and is very easy for improving the medication compliance of the patient.

The invention belongs to the technical field of cultivation of rhizoma gastrodiae and particularly relates to a method for cultivating the rhizoma gastrodiae by using tea branches. The method comprises the following specific steps: (1) preparing a culture material; (2) preparing fungus sticks; and (3) carrying out honey fungus inoculation and culture. According to the method, through carrying out cultivation by using the fungus sticks, the preparation is convenient, the cost is low, the fungus sticks not only are free of infectious microbes, insect pests and viruses, but also can enable inocula to be high in spawn running speed, the propagation of the infectious microbes is effectively inhibited, and the increase of effect and yield of spawn running is facilitated; during culture, lighting treatment is carried out, and a nutrient solution is injected regularly, so that the activity, disease resistance and drought resistance of the inocula are effectively and remarkably improved, the cultivation cycle is shortened, old mycoderma is absent, and the yield of the rhizoma gastrodiae can be increased; and the rhizoma gastrodiae can be harvested in one year of cultivation, the conversion ratio reaches 65.28% or more, the content of effect ingredients in the rhizoma gastrodiae is effectively increased, the content of gastrodine can reach 1.31% or more, the content of rhizoma gastrodiae polysaccharides can reach 47.78% or more, and the medicinal value of the rhizoma gastrodiae is effectively increased.

The invention provides a medicament for curing sedation, sleep and cardiovascular neurogenic headache, and a process for preparation. The invention particularly relates to a dripping pill which contains acetyl gastrodine and a process for preparation. The invention overcomes the shortcomings of the prior dripping pills that pure natural degrees of findings which are used by the prior dripping pills are not high, and chemosynthesis findings which are commonly used are not in food additives catalogs of some countries, and tastes of the dripping pills are worse. The invention is a pharmaceutical preparation whose natural degree is higher, safety is stronger, and side effect is lower.

The invention relates to a gastrodine compound and a pharmaceutical composition thereof. The gastrodine compound is a crystal. The X-ray powder diffraction determines that the characteristic peaks are displayed when 2theta+ / -0.2 degree is 4.5 degrees, 5.7 degrees, 7.9 degrees, 10.3 degrees, 11.2 degrees, 13.0 degrees, 16.4 degrees, 19.6 degrees, 21.2 degrees, 22.7 degrees, 24.8 degrees, 26.7 degrees, 29.6 degrees, 34.1 degrees and 35.3 degrees. The gastrodine compound has very high stability, thereby greatly enhancing the medicine safety. The invention also relates to a pharmaceutical composition preparation containing the gastrodine compound. The composition preparation can be a freeze-dried powder injection, injection, tablet or capsule. The gastrodine freeze-dried powder injection, injection, tablet or capsule preparation provided by the invention has the advantages of simple prescription technique, obviously higher stability, and enhances the medicine safety and effectiveness.

The invention provides a cigarette additive. The cigarette additive is prepared from rhynchophylline, gastrodine or gastrodine derivatives and inonotus obliquus, the rhynchophylline, the gastrodine orthe gastrodine derivatives and the inonotus obliquus are made into a mixture, the mixture is sprayed on tobacco shreds or added into electronic cigarette accessories, and prepared cigarettes can effectively relieve the problems such as heart addiction, depression and anxiety emotion and poor sleep of meth addicts. In addition, the amount of the rhynchophylline, the gastrodine or the gastrodine derivatives and the inonotus obliquus added in the cigarettes is strictly controlled, on the one hand, the economical burden brought to consumers due to the high cost can be avoided, on the other hand,the original flavor of the cigarettes can further be ensured, and compliance of patients is good.

The invention discloses a nourishing chafing dish soup base, which is composed of fresh black-bone chicken soup 1,500 g, Alisma orientale 80-120 g, Panax ginseng 40-60 g, Gastrodia elata 40-60 g, cassia bark 8-12 g, star aniseed 20-30 g, cumin 20-30 g, dried chili powder 25-35 g, pricklyash peel 10-20 g, clove 25-35 g, fermented glutinous rice liquid 40-60 g, and a proper amount of table salt. The black-bone chicken is rich in vitamins, trace elements and amino acids, and is a domestic fowl with high nutritive value; Alisma orientale has the effects of promoting diuresis, resolving phlegm, reducing pathogenic fire, removing moist heat, replenishing vital essence, and invigorating qi; Panax ginseng has the effects of invigorating qi, tonifying blood, refreshing and caring skin and is a precious Chinese medicinal material with slight sweetness; and Gastrodia elata contains pharmacological active substances such as gastrodine and vanillin, as well as antifungal proteins, and amino acids and trace elements needed by human body. The chafing dish soup produced with the inventive chafing dish soup base has good taste and high nutritive value, and low liability to suffer from excessive internal heat.

The invention relates to a gastrodine mouse mouse disintegration tablet, which uses gastrodine as main drug, with gastrodine coat capsule, diluter, and disintegrator. Wherein, the invention is characterized in that: said capsule is made from gastrodine, coated by acrylic acid resin and acrylic acid; and the disintegrator is low-replace hydroxypropyl cellulose and crosslink polyvinyl pyrrolidon. The invention has better disintegration time limit, with uniform solution.

The invention discloses a nasal spray formulation of gastrodine. The inventive nasal spray formulation makes the gastrodine pass through the blood brain barrier to target to the brain by nasal administration, which is convenient in administration, and reduces the dosage and times of administration to reach the necessary medicament brain concentration, the concentration of peripheral drugs, and the burden of organs, such as kidney and liver. Furthermore, the nasal administration is especially suitable for children, old people, the bedridden, dysphagia patients, and patients in restriction of drinking water based on the medical order, in order to change the dependence of administration of patients and improve the effect of drugs.

The invention relates to a rhizoma gastrodiae and eucommia bark healthcare capsule and a preparation method thereof. The invention relates to a healthcare product for helping to reduce the blood pressure and improve the sleep quality and a preparation method thereof. The medicine of the rhizoma gastrodiae and eucommia bark healthcare capsule is prepared by uniformly mixing fine powder of fresh rhizoma gastrodiae extract and folium cortex eucommiae extract with granularity less than 80 meshes, and the weight ratio of the rhizoma gastrodiae extract to the folium cortex eucommiae extract is as follows: the rhizoma gastrodiae extract is 3 to 7 portions; and the folium cortex eucommiae extract is 1 portion. The capsule has a reasonable formula and has good functions on helping to reduce the blood pressure and improve the sleep quality; and the manufacturing method is more scientific and effective ingredients such as unsaturated amino acid and so on contained in rhizoma gastrodiae are fullypreserved, thereby the activity of gastrodine in the product can be greatly improved. The extract obtained by juice extraction and purification of fresh rhizoma gastrodiae is mixed with the folium cortex eucommiae extract, thereby the effects of assisting to reduce the blood pressure and improve the sleep quality are better and particularly the side effects on the liver and the kidney caused by taking western medicines and other hypotensor for a long time can be avoided. Eucommia barks have the function of bidirectional regulation of the blood pressure, thereby the blood pressure of a user taking the medicine can not be reduced too low when the capsule is used.

An oral disintegrating tablet of gastrodine for treating neurasthenia, neurasthenia syndrome and angioneurotic headache is prepared from gastrodine, souring agent, excipient and disintegrant.

The invention discloses the application of gastrodine to the preparation of caspase-3 active inhibitor and belongs to the field of pharmacy. The gastrodine is applied to the preparation of caspase-3 active inhibitor, the caspase-3 active inhibitor can be used for treating diseases including neurodegenerative diseases, cardiovascular and cerebrovascular diseases, osteoarthritis, rheumatoid arthritis, and the like, specifically such as Parkinson disease, Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, traumatic brain injury, spinal cord injury, severe hepatitis, liver dysfunction, osteoarthritis, rheumatoid arthritis, acquired immunodeficiency syndrome, myocardial infarction, cerebral ischemia and the like. The application of gastrodine has the advantage of blocking the specific protease needed by apoptosis without any adverse reaction which is caused by the application of the majority of broad spectrum drugs.