59 results about "Gastrodine" patented technology

The present invention relates to one kind of Chinese medicine film preparation capable of dissolving in oral cavity fast. The film preparation consists of active Chinese medicine component(s) in 0.1-99 wt%, filming material in 0.1-90 wt% and medicinal supplementary material in 0-30 wt%. The active Chinese medicine components includes red sage extract, total arasaponin, breviscapine, gastrodine, acetyl gastrodine, etc. The Chinese medicine film preparation has convenient taking, fast absorption, high bioavailability, less irritation to digestive tract mucous membrane and other advantages, and is especially suitable for use in treating acute cardiac and cerebral vascular diseases and migraine.

The present invention discloses microbe cell synthesis process of converting p-hydroxy benzyl alcohol to synthesize gastrodine. The process is one converting reaction of wet cell of rmillaria luteo-virens ZJUQH in 1-10 g / 100ml and 0.22 micron microporous film filtered p-hydroxy benzyl alcohol in 0.1-3.1 mmol / L, in the culture liquid comprising sterilized potato in 2 wt% concentration and glucose in 0.5 concentration, at temperature of 20-25 deg.c and shaking table rotation speed of 50-200 rpm for 1-3 days. Compared with available plant cell conversion process, the microbe cell synthesis process has the advantages of short period, simple operation and easy control.

The invention discloses a pharmaceutical composition, its preparing process and use, wherein the composition comprises epimedium extract, hooked uncaria extract and puerarin by the weight ratio of 20-500 : 3-80 : 40-1000. The composition can be prepared into clinically and pharmaceutically acceptable dosage forms including injections, tablets, capsules, soft capsules, dripping pills, oral liquids, and granules. The composition can be used for treating hypertension, cephalalgia, nervous prostration and cardiovascular and cerebrovascular diseases.

The invention discloses oral liquid of grey polypore which is rich in gastrodine and organic selenium and a process for preparation. Fresh gastrodia elata and bitter garlic are pre-processed, dried, and grinded by the invention, which take deep fermentation with grey polypore in powder shape to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium. The process for preparation comprises first, culturing bacterial of a slant face of the grey polypore, second, culturing liquid seed, third, processing raw material which are gastrodia elata and bitter garlic, fourth, fermenting, fifth, post-treating products. In the oral liquid of the invention, the content of gastrodine is 2.2 to 2.8mg / 100ml, the content of crude polysaccharide is 4.0 to 4.8mg / L, and the content of organic selenium is 0.11*10-6 to 0.21*10-6. Compared with the prior art, the oral liquid of the invention can play a stronger effect of anti-tumor and enhance human immunity, and inhibit and kill cancer cells without hurting normal cells of human bodies simultaneously, which can service for human health. The process of the invention can lead gastrodine, bitter garlic, and grey polypore to be fermented together to prepare oral solution which is rich in gastrodine, crude polysaccharide, and organic selenium, and the oral solution can be produced in large scale.

The present invention discloses microbe cell synthesis process of converting p-hydroxy benzyl alcohol to synthesize gastrodine. The process is one converting reaction of wet cell of rmillaria luteo-virens ZJUQH in 1-10 g / 100ml and 0.22 micron microporous film filtered p-hydroxy benzyl alcohol in 0.1-3.1 mmol / L, in the culture liquid comprising sterilized potato in 2 wt% concentration and glucose in 0.5 concentration, at temperature of 20-25 deg.c and shaking table rotation speed of 50-200 rpm for 1-3 days. Compared with available plant cell conversion process, the microbe cell synthesis process has the advantages of short period, simple operation and easy control.

A pure-component Chinese medicinal preparation for treating headache and its preparation process, using Gastrodia elata and Ligusticum chuanxiong as basic formulation, adopting modern flash extraction technique, combining macroporous resin, normal / reversed-phase silica gel chromatography technique and high-speed counter-current chromatography preparation technique, extracting a volatile oil fraction containing butylphthalide as main component, an alkaloid fraction containing ligustrazine as main component, an organic acid fraction containing ferulic acid as main component, a lactone fraction containing ligustilide as main component, a phenols fraction containing gastrodine as main component and a polysaccharide fraction containing polysaccharides from Ligusticum chuanxiong as main component. The Chinese medicinal preparation provided by the invention has definite curative effect, definite composition, controllable quality, and simple operation method.

A low-capacity intravenous injection of gastrodine for treating neurasthenia, neurasthenia syndrome, cerebral trauma syndrome, dizziness, Meniere's disease, reuralgia, headache, etc is prepared from gastrodine, the water for injection and metallic chelating agent. Its preparing process is also disclosed.

The invention discloses C-glycoside with substituted aromatic ring, S-glycoside compounds, pharmaceutical compositions with effective dose compounds, and applications of the compounds and compositions for preparing cardio-cerebrovascular anti-hypoxic ischemia medicine and neuroprotection medicine. In the compounds are c-glycoside compounds when X represents CH2, wherein when Y represents CH2, n may be 0 or 1, when n is 0, m is 0, and when n is 1, m is 0 or 1; when Y represents NH, n=m=1; when X represents S, the compounds is S-glycoside compounds, wherein Y represents CH2, n may be 1, 2 or 3, and m is 0; R represents mono-substituted, disubstituted, tri-substituted hydrogen C1-C3 straight-chain or branched chain alkyl and hydroxyl, or C1-C3 straight-chain or carboxylic acid ester. 14 compounds found have better protective action to hypoxia-reoxygenation injury of myocardium than or equal to salidroside; 15 compounds have stronger neuroprotection activity than or equal to gastrodine.

The invention relates to a gastrodine compound and a pharmaceutical composition thereof. The gastrodine compound is a crystal. The X-ray powder diffraction determines that the characteristic peaks are displayed when 2theta+ / -0.2 degree is 4.5 degrees, 5.7 degrees, 7.9 degrees, 10.3 degrees, 11.2 degrees, 13.0 degrees, 16.4 degrees, 19.6 degrees, 21.2 degrees, 22.7 degrees, 24.8 degrees, 26.7 degrees, 29.6 degrees, 34.1 degrees and 35.3 degrees. The gastrodine compound has very high stability, thereby greatly enhancing the medicine safety. The invention also relates to a pharmaceutical composition preparation containing the gastrodine compound. The composition preparation can be a freeze-dried powder injection, injection, tablet or capsule. The gastrodine freeze-dried powder injection, injection, tablet or capsule preparation provided by the invention has the advantages of simple prescription technique, obviously higher stability, and enhances the medicine safety and effectiveness.

The invention discloses a nasal spray formulation of gastrodine. The inventive nasal spray formulation makes the gastrodine pass through the blood brain barrier to target to the brain by nasal administration, which is convenient in administration, and reduces the dosage and times of administration to reach the necessary medicament brain concentration, the concentration of peripheral drugs, and the burden of organs, such as kidney and liver. Furthermore, the nasal administration is especially suitable for children, old people, the bedridden, dysphagia patients, and patients in restriction of drinking water based on the medical order, in order to change the dependence of administration of patients and improve the effect of drugs.

The invention relates to a rhizoma gastrodiae and eucommia bark healthcare capsule and a preparation method thereof. The invention relates to a healthcare product for helping to reduce the blood pressure and improve the sleep quality and a preparation method thereof. The medicine of the rhizoma gastrodiae and eucommia bark healthcare capsule is prepared by uniformly mixing fine powder of fresh rhizoma gastrodiae extract and folium cortex eucommiae extract with granularity less than 80 meshes, and the weight ratio of the rhizoma gastrodiae extract to the folium cortex eucommiae extract is as follows: the rhizoma gastrodiae extract is 3 to 7 portions; and the folium cortex eucommiae extract is 1 portion. The capsule has a reasonable formula and has good functions on helping to reduce the blood pressure and improve the sleep quality; and the manufacturing method is more scientific and effective ingredients such as unsaturated amino acid and so on contained in rhizoma gastrodiae are fullypreserved, thereby the activity of gastrodine in the product can be greatly improved. The extract obtained by juice extraction and purification of fresh rhizoma gastrodiae is mixed with the folium cortex eucommiae extract, thereby the effects of assisting to reduce the blood pressure and improve the sleep quality are better and particularly the side effects on the liver and the kidney caused by taking western medicines and other hypotensor for a long time can be avoided. Eucommia barks have the function of bidirectional regulation of the blood pressure, thereby the blood pressure of a user taking the medicine can not be reduced too low when the capsule is used.

An oral disintegrating tablet of gastrodine for treating neurasthenia, neurasthenia syndrome and angioneurotic headache is prepared from gastrodine, souring agent, excipient and disintegrant.