A pure-component Chinese medicinal preparation for treating headache and its preparation process

Abstract

A pure-component Chinese medicinal preparation for treating headache and its preparation process, using Gastrodia elata and Ligusticum chuanxiong as basic formulation, adopting modern flash extraction technique, combining macroporous resin, normal / reversed-phase silica gel chromatography technique and high-speed counter-current chromatography preparation technique, extracting a volatile oil fraction containing butylphthalide as main component, an alkaloid fraction containing ligustrazine as main component, an organic acid fraction containing ferulic acid as main component, a lactone fraction containing ligustilide as main component, a phenols fraction containing gastrodine as main component and a polysaccharide fraction containing polysaccharides from Ligusticum chuanxiong as main component. The Chinese medicinal preparation provided by the invention has definite curative effect, definite composition, controllable quality, and simple operation method.

Description

technical field [0001] The invention specifically relates to a pure-component traditional Chinese medicine preparation for treating headaches and a preparation process. Background technique [0002] Migraine is a common chronic neurovascular disorder, which is called primary angioneural headache in modern medicine. It is mainly manifested as pulsating pain in the frontal, temporal or half of the head on one or both sides, often accompanied by symptoms such as nausea, vomiting, photophobia, etc. It belongs to 10 categories (species) of major diseases that seriously endanger human health. In the United States, the economic loss caused by migraine attacks alone is as high as $18 billion a year. The 2010 China primary headache epidemiological survey data show that among the population aged 18-65 in my country, the incidence rate of migraine is 9.3% (according to the 5th national census, the total population exceeds 1.3 billion, approximately more than 120 million people), the p...

AI Technical Summary

Problems solved by technology

[0005] However, traditional Chinese medicine is a complex system with multiple effective substances and multi-target action mechanisms. At present, although many classic prescriptions of traditional Chinese medicine have been developed into new drugs by pharmaceutical companies, forming a Chinese patent medicine market based on traditional compound prescriptions, most companies are also The secondary development of classic prescriptions or marketed Chinese patent medicines is the focus of research and development. However, due to defects such as unclear material basis and unclear treatment mechanism, there is no substantial breakthrough in the research and development of traditional Chinese medicines, so it is impossible to develop Modern Chinese medicines that meet international medical standards, have competitive and independent intellectual property rights, and have a long life cycle

In fact, there is no modern traditional Chinese medicine preparation for treating headaches with definite curative effect, clear ingredients, convenient and controllable administration.

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