103 results about "Photophobia" patented technology

The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.

A low-concentration atropine solution for preventing myopia progression contains an atropine concentration less than 0.1% (w / w). Preferably, the atropine concentration is 0.05% (w / w) in optimal situation. The low-concentration atropine solution in treatment causes less photophobia and systemic side-effects to patients and has excellent compliance to reduce damages from ultraviolet and hazard blue light and to avoid visual morbidities such as cataract and retinal macula lutea deterioration.

A method of treating headache is provided using a water soluble magnesium salt. Specifically, a method of treating a headache is provided for an individual having a serum ionized magnesium concentration of 0.44 mmoles / L to 0.53 mmoles / L and having at least one headache symptom by administering an amount of a water soluble magnesium salt sufficaent to inhibit at least one headache symptom in the individual within 24 hours and to raise the serum ionized magnesium concentration in the individual to within a normal ionized magnesium concentration range of 0.54 mmoles / L to 0.67 mmoles / L. Headache symptoms which may be inhibited include: pain, aura, photophobia, nausea, unilateral pain and phonophobia.

S-alkylsiothiouronium derivatives such as S-ethylisothiouronium diethylphosphate are used for the treatment of headaches, in particular, migraines, as well as for the prevention or treatment of nausea and vomiting. The compositions of the invention are also effective in preventing or alleviating emesis associated with migraines or other medical conditions such as chemotherapy or radiotherapy, as well as other symptoms of migraines including phonophobia and photophobia.

The present invention relates to oxygenated ophthalmic topical compositions and methods of administering oxygenated ophthalmic topical compositions. The present invention also encompasses methods for making and administering the oxygenated ophthalmic topical compositions for use in treating or ameliorating pathologic conditions, complications, diseases and symptoms related to hypoxia of the anterior eye structure, including corneal neovascularization (CNV), edema, abrasions, infections, infiltrates, dry eye syndrome, contact lens intolerance; and redness, blurred vision, discomfort, foreign body sensation, photophobia, and irritation.

The present invention describes a method for the treatment and / or prevention of migraine and associated symptoms (nausea, vomiting, photophobia, phonophobia, etc.) comprising co-therapy with a therapeutically effective amount of one or more anti-migraine agents and one or more anticonvulsant derivatives.

This invention relates to methods of screening for anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof, for potential use in treating or preventing PACAP-associated photophobia or light aversion, and therapeutic compositions containing and methods of using anti-PACAP antibodies, or anti-PACAP receptor antibodies, and antigen binding fragments thereof.

Zeaxanthin, a dietary carotenoid that occurs in very small quantities in corn, spinach, and other dietary sources, can reduce light hyper-sensitivity and various related conditions (such as migraine or other recurrent headaches) in people who suffer from it. Preferred dosages range from about 10 to about 100 mg per day, depending on the severity of condition, and the weight and medical status of the person. High dosages during an initial “buildup” dosing regimen can promote increased concentrations in the macula and lens, and lower dosages can then be used for maintenance purposes. Lutein may be able to achieve similar results, but because of certain molecular and cellular factors, zeaxanthin is preferable. Additional active agents (such as bilberry or other plant extracts, Vitamins C or E, zinc, etc.) can also be included or coadministered with any such formulations.

The present invention is directed to methods of inhibiting or preventing photophobia in subjects in need thereof using anti-CGRP antibodies or antibody fragments that inhibit photophobia, especially CGRP-associated photophobia. These antibodies and fragments are useful in treating different disorders associated with photophobia such as migraine, cluster headaches and the like.

The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the diseases of deficiency of liver-yin and kidney-yin, dry eyes and photophobia, poor vision, blurring of vision and epiphora induced by wind etc, and its preparation process. It can be made into dripping pills and soft capsule preparation.

The invention relates to a traditional Chinese medicine composition for vision rehabilitation and a preparation method thereof. In the prior art, the processes all have the problems that the processes are coarse, the prepared preparations are instable, the contents of active constituents are low and the treatment effect in the course of practical application is unsatisfied. The composition is prepared from the following 24 traditional Chinese medicines: antelope horn, caltrop, equisetum, chrysanthemum, plantain seed, selfheal, cassia seed, ginseng, cornel (prepared), dendrobe, wolfberry fruit, dodder, glossy privet fruit, abalone shell, coptis root, pipewort, fiveleaf akebia, prepared rehmannia root, yam, alisma, poria, moutan bark, radix rehmanniae and betel palm. The process is advanced, the content of active constituents is high and the preparation has good stability. The composition has the efficacies of nourishing liver and kidney, nourishing yin, promoting the production of the body fluid, removing heat from the liver, and improving eyesight, and is mainly used for patients having the symptoms of photophobia, blurred vision, glaucoma and primary and medium cataract caused bydeficiency of liver-yin and kidney-yin. The clinic pharmacodynamic test effect is obviously improved, the bioavailability is high and no toxic or side effect is generated.

The invention discloses a composition for preventing and treating asthenopia and a preparation method and application of the composition. Each 100 parts by weight of composition is prepared from the following raw materials in parts by weight: 10-40 parts of semen cassia, 5-30 parts of blueberries / bilberries, 10-30 parts of lutein ester / lutein / lutein ester microcapsule powder, 10-30 parts of purple perilla seed oil / perilla oil microcapsule powder, 1-15 parts of phospholipid, 1-15 parts of guarana extracts, 0.1-3 parts of taurine, 0.01-0.5 part of vitamin C and 0.001-0.1 part of vitamin A / beta carotene. The composition can be compounded with an adjuvant for preparing drugs, health products and foods for preventing and treating asthenopia. The composition has the effects of supplementing eyes with nutrients and preventing and treating asthenopia, and can be applied to prevention and treatment of diseases, such as asthenopia, eye dryness, foreign body sensation eyelids heaviness, blurred vision, photophobia, tears, eyeball dryness, eye pain and eye congestion.

The invention discloses rhizoma chuanxiong shrimp shell biscuits which comprise, by weight, 110-120 parts of flour, 20-25 parts of corn powder, 8-10 parts of walnut powder, 16-20 parts of artificial cream, 10-12 parts of shrimp shell, 7-10 parts of cabbage, 2-4 parts of Chinese wolfberry fruit, 1-3 parts of poria cocos, 2-3 parts of semen cassiae, 5-7 parts of honeysuckle, 4-6 parts of rhizoma chuanxiong, 2-3 parts of grape leaf, 1-3 parts of sunflower disk, 1-3 parts of dragon's tongue leaf, 1-2 parts of salviae miltiorrhizae, 10-15 parts of cane sugar powder, 2-4 parts of liquid malt extract, 1-2 parts of sodium bicarbonate and 0.8-1 part of pollen pini. The biscuits produced by the method is good in fragrance, color and taste, and high in health-care value; calcium of the puffed shrimp shell is easy to absorb, the semen cassiae is capable of removing heat from the liver and tonifying the kidney, improving eyesight, inducing diuresis and relaxing bowels, and treating sore red swollen eyes, photophobia with a lot of tears, glaucoma, night blindness, headache and dizziness, dim vision, cirrhotic ascites, difficult urination, habitual constipation and the like, and the salviae miltiorrhizae and the rhizoma chuanxiong are capable of activating blood, and treating and preventing cardiovascular and cerebrovascular diseases; the biscuits are capable of regulating human bodies, adjusting sub-health, and increasing health.

The invention relates to a gum and a preparation method thereof. The gum comprises lutein the weight of which accounts for 0.001 to 3.6 percent of the total weight of the gum. The method for preparing the gum comprises the following steps: in the conventional preparation process of the gum, adding the lutein the weight of which accounts for 0.001 to 3.6 percent of the total weight of the gum into the raw materials for preparing the gums; mixing the obtained mixture evenly; rolling the obtained mixture, cutting the rolled mixture into slices, and drying the slices so as to obtain the gum. By chewing the lutein gum of the invention, the eye symptoms such as lachrymation, irritation, blurred vision, dryness, photophobia, itch and heaviness, and the like can be eliminated obviously, therefore. The gum has the functions of protecting eyesight and freshening breath, and the like.

The invention discloses a novel preparation method of 'Mingmu Dihuang' and its formulation, characterized by the modification to the preparing process by using the novel medicament preparing technologies, which achieves the beneficial effects of good curative effect, small amount of administration and easiness in carrying. The preparation can be used for treating photophobia and irritated epiphora with warm tear.

Devices / techniques coupleable to patient sensors, ambient environment, and external sensory input. Devices / techniques receive / maintain information; correlate received / maintained information with measures associated with detecting / monitoring, predict, prevent / treat, and train / reward patient self-care, for dry eyes. Devices / techniques detect / monitor, predict, and prevent / treat dry eyes in real time; and train / reward patients to conduct self-care for dry eyes. The devices / techniques provide adjusted sensory inputs to prevent / treat dry eyes, or to train / reward patients to conduct self-care for dry eyes. The devices / techniques cooperate with other devices, including devices worn by nearby patients, to receive / maintain information about the ambient environment, or communicate with medical personnel. The devices / techniques adjust parameters they use, in response to received information that differs from predictions, to provide superior behavior, and communicate with other devices and medical personnel. Devices / techniques are combined with devices / techniques that perform similar functions for other conditions, migraines / photophobia, neuro-opthalmic disorders, and other ocular conditions, and for combinations of dry eyes with other conditions.

The invention discloses a novel 'QiJu Dihuang' formulation and its preparation, characterized by the modification to the preparing process by using the novel medicament preparing technologies, which achieves the beneficial effects of good curative effect and small amount of administration. It can be used for treating vertigo, akoasm and photophobia.

The invention aims at providing a product for relieving visual fatigue and a preparation method thereof. The product comprises the components in parts by weight: 22-28 parts of eyebright, 20-26 parts of xanthin, 14-18 parts of huckleberry, 15-20 parts of ginkgo leaves, 16-22 parts of grape pips, 1-5 parts of zinc lactate and 1-5 parts of vitamin A. By specially combining natural Chinese herbal medicines, the product achieves the effects of preventing, improving and treating blurred vision, dry eye syndrome, swollerpain of eyes, photophobia and the like which are caused by excessively using eyes, is simple in the preparation method and stable in technical condition, and is suitable for large-scale industry production.

The present invention provides medicaments for treating or preventing a disease, disorder, or condition associated with extracellular matrix (ECM) abnormality in a corneal endothelium, wherein the medicaments comprise a TGF-beta signal inhibiting agent. More specifically, this disease, disorder, or condition is a disorder associated with Fuchs' endothelial corneal dystrophy. Such a disorder includes photophobia, blurred vision, vision disorder, eye pain, lacrimation, hyperemia, pain, bullous keratopathy, ophthalmic unpleasantness, a decrease in contrast, glare, edema in corneal stroma, bullous keratopathy, corneal opacity, and the like. A preferable TGF-beta signal inhibiting agent includes 4-[4-(1,3-benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide.

The invention discloses a Chinese herbal medicine formula for preventing cold, cough, photophobia and tearing of goats. The Chinese herbal medicine formula consists of the following components in percentage by weight: 12-14% of schizonepeta, 8-10% of Chinese parsnip root, 8% of radix bupleuri, 8% of platycodon grandiflorum, 6% of liquorice, 6% of mint, 6% of houttuynia cordata, 8-10% of isatis root, 6% of bunge corydalis herb, 6% of dried alum, 6% of Chinese gall leaven, 4% of dried salt, 6% of coptis root and 4% of alum. Researches show that the Chinese herbal medicine formula can take an excellent effect on preventing cold, cough, sneezing, photophobia, tearing and other diseases of the goat, and can achieve a prevention rate above 95%; to avoid the diseases, the Chinese herbal medicines are added to a green feed in proportion; the Chinese herbal medicine formula is simple and convenient in prevention of diseases, and can be used for reducing the goat treating cost, reducing the cost and improving the economic benefit.

The invention belongs to the technical field of biological medicines and in particular relates to an acremonium terricola culture and application thereof. The acremonium terricola culture provided by the invention can effectively alleviate visual fatigue symptoms such as eye distension, sore eyes, photophobia, blurred vision, dry eyes and fading eyesight. The acremonium terricola culture provided by the invention is low in production cost, can be easily obtained in large scale and can be applied in preparation of medicines for relieving visual fatigue conveniently.

The present invention relates to a Chinese medicine composition and its preparation method. In particular, it relates to a Chinese medicine prescription for curing the diseases of deficiency of liver-yin and kidney-yin, dizziness, tinnitus, photophobia, epiphora induced by wind and poor vision, etc, and its preparation process. Said invention can be made into dripping pills and soft capsule preparation.

The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and / or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated. Other embodiments of the invention contemplate using anti-PACAP antibodies, and binding fragments thereof, for the diagnosis, assessment, and treatment of diseases and disorders associated with PACAP and conditions where antagonism of PACAP-related activities, such as vasodilation, photophobia, mast cell degranulation, and / or neuronal activation, would be therapeutically beneficial.

Pharmaceutical compositions and methods are provided to treat headache, headache-associated symptoms, photophobia, or adverse effects associated with triptan administration.

The invention discloses a bean dreg chrysanthemum steamed bun. The bean dreg chrysanthemum steamed bun is made of raw materials according to the following weight part ratio: 60-72 parts of flour, 10-12 parts of corn flour, 6-8 parts of beam dregs, 6-8 parts of grapes, 3-4 parts of avers, 2-3 parts of fructus amomi, 1-3 parts of folia perillae acutae, 1-2 parts of semen cassiae, 3-4 parts of cowpea leaves, 1-3 parts of luffa flowers, 2-3 parts of sunflower discs, 3-4 parts of cortex moutan, 4-6 parts of chrysanthemum, 0.1-0.3 part of citric acid and 0.06-0.08 parts of pectin. The bean dreg chrysanthemum steamed bun is smooth and rich in taste. Because the bean dregs are added, waste is utilized, and production cost of the bean dreg chrysanthemum steamed bun is greatly reduced. Through mixing granulation of the bean dreg and other raw materials, loss of nutritional ingredients in the steaming process is reduced, and health care value is improved. The semen cassiae can cleanse the liver, benefit the kidneys and improve eyesight, is diuretic and laxative, and is mainly used for curing swelling and pain of eyes, photophobia, many tears, optic atrophy, night blindness, headaches, dizziness, obscure object-seeing effect, ascites due to cirrhosis, difficult urination, habitual constipation and the like. The bean dreg chrysanthemum steamed bun can promote the circulation of qi and conduct flavoring, and wake up the spleen to regulate the stomach, and is beneficial to human health.

The invention relates to braised duck food in the catering industry and a making method thereof. The invention combines medlar with the braised duck so as to obtain a special flavor of Chinese herbal medicine in addition to the traditional flavor of the braised duck; and moreover, the invention has obvious food therapy effect for symptoms such as liver-kidney yin deficiency, dizziness, tinnitus, photophobia, shed tears, poor vision, and the like.

The invention discloses a traditional Chinese medicine for treating oculopathy, which is mainly suitable for ophthalmological diseases such as conjunctivitis, stye, trachoma, and the like and belongs to the field of medicaments for eyes. The traditional Chinese medicine is prepared by the steps of grinding raw material medicaments in part by weight: 60 parts of calcined calamine, 6 parts of borneol, 5 parts of amber, 5 parts of calcined coral, 1.5 parts of pearl powder, 3 parts of cinnabar, 1.5 parts of musk, 6 parts of borax and 9 parts of bear gall into fine powder and mixing the powder uniformly. A using method of the traditional Chinese medicine comprises the steps of: dipping clean cold water and the medicinal powder with a glass rod, and applying the mixture to canthi for three times a day. The traditional Chinese medicine has the good treatment effects on various phlogistic eye diseases, bloodshot eyes and gall, epiphora induced by wind, nebula and cataract, blepharitis ciliaris and photophobia, and has the advantages of good treatment effect, no toxic or side effect and relapse prevention after treatment.

The invention discloses a traditional Chinese medicine patch for visual fatigue and eye skin care and a preparation method thereof. The preparation method includes: weighing black bean and agaric, adding water for soaking for 30min, adding platycladus orientalis leaf, Chinese holly leaf, semen cuscutae, fructus rosae, flos carthami, glossy privet leaf and rhizoma chuanxiong, adding water of 10 times and 8 times of amount of added ingredients for decocting twice, extracting liquid once every other 40min, and adopting a micrometer film to filter extract to obtain filtrate; using anhydrous alcohol to soak carrot and lemon, extracting once every other 40min, extracting extract, and using a proper amount of glycerin for dispersion to obtain glycerin liquid; merging the filtrate and the glycerin liquid to obtain product stoste, and using the stoste to soak nonwoven cloth to obtain the patch. The traditional Chinese medicine patch can improve or relieve visual fatigue symptoms like visual disorder, eye fatigue, photophobia, ache, tearing, foreign body sensation, dry eyes and ophthalmospasm and can relieve and eliminate symptoms like eye skin dark circle, crows-feet, eye bag and edema.

The invention relates to a traditional Chinese medicine composition, preparation and preparation method for treating dry eye. A preparation process is used to make preparations. The traditional Chinese medicine composition of the present invention has the effects of nourishing the liver and kidney, clearing the liver and improving eyesight, clearing away heat and detoxification, nourishing yin and moistening dryness, nourishing qi and blood, promoting blood circulation and invigorating the spleen, increasing eye moisture, improving dry eyes, photophobia, and blurred vision, and has the effect on dry eyes. Eye disease has a good curative effect. No toxic and side effects have been found in clinical and pharmacological experimental observations, and it has broad prospects for popularization and application.