3 results about "Burning Pain" patented technology

The application discloses a kind of solid teeth pain-relieving and inflammation-clearing traditional Chinese medicine composition, it is related to traditional Chinese medicine product technical field.The composition is composed of gypsum, raw rehmannia, coptis, talc, ocher, radix cyathulae and salvia miltiorrhiza seven raw medicinal materials, wherein gypsum, raw rehmannia are monarch drug, clear and purge stomach fire, cool blood and nourish yin;Coptis, talc are ministerial drug, clear heat and dry dampness, lead heat down;Ocher, radix cyathulae are auxiliary drug, heavy town counteract, lead fire down;Salvia miltiorrhiza is servant drug, promote blood circulation and remove blood stasis, promote tissue repair.Modern pharmacological research shows that each drug of the present party has the effects of anti-inflammatory, analgesic, antibacterial, improving microcirculation and protecting periodontal tissue etc.Clinical observation shows that the pain of most patients caused by stomach fire attacking upward, gum redness and swelling, burning pain, bleeding is significantly reduced after taking 1-2 doses, redness and swelling gradually subside.Compared with existing Chinese patent medicines, the present application is simple in prescription, low in cost, has the dual effects of rapid pain relief and long-term tooth fixation, and is especially suitable for patients with recurrent toothache and early periodontitis.

Keratoconjunctivitis sicca is a general term of a plurality of diseases which are accompanied by eye discomfort and (or) ocular surface tissue lesion characteristics and are caused by tear quality or quantity abnormality or dynamic abnormality caused by any reason, and belongs to the field of chronic keratoconjunctivitis in western medicine. The common symptoms comprise eye dryness, easy fatigue, eye itching, foreign body sensation, burning pain, secretion viscosity, wind afraid, photophobia, lacrimation and external stimulation sensitivity; the two eyes of a patient with serious diseases in the later stage are red and swollen, hyperemia and keratinization, corneal epithelium exfoliation and filament adhesion exist, keratoconjunctival lesion can be caused if the patient is injured for a long time, and the continuous development of the keratoconjunctival lesion possibly causes irreversible influence on vision. The traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in parts by mass: 100 to 1000 parts of radix rehmanniae, 100 to 1000 parts of radix ophiopogonis, 100 to 1000 parts of herba dendrobii, 100 to 1000 parts of bulbus lilii, 100 to 1000 parts of radix polygonati officinalis and 200 to 500 parts of flos chrysanthemi. Corresponding auxiliary materials can also be added into the traditional Chinese medicine composition to prepare clinically common tablets, granules and oral dosage forms.

The application discloses an esterase-responsive lipid prodrug capsaicin nanoassemblies as well as a preparation method and application thereof, the nanoassemblies are formed by self-assembly of lipid prodrug capsaicin in an aqueous medium, and the average particle size of the nanoassemblies is 50-300 nm. The nanoassemblies can efficiently penetrate a nerve bundle membrane barrier, locally form a drug depot in nerve tissue, and slowly release active capsaicin under the action of esterase, so that long-acting, safe and selective analgesia is realized, and key problems such as poor permeability of free capsaicin, severe burning pain caused by injection, and narrow treatment window are solved.