600 results about "Cutin" patented technology

Personal care compositions containing an active selected from the group consisting of phlorogine, phlorgine BG, deoxyArbutin, sucrose dilaurate, bakuchiol, pyrenoine, millet, arlatone dioic acid, cinnamic acid, ferulic acid, achromaxyl, methyl nicotinamide, oil soluble licorice extract, folic acid, undecylenic acid, zinc undecylenate, L-tryptophan, thiamine HCl, hexylresorcinol, lipidami red vine, dragosine, methyl gentisate, inositol, symdiol 68, laminaine, their salts, their derivatives, their precursors, and / or combinations thereof. Methods for regulating the condition of mammalian keratinous tissue by topically applying the personal care compositions are also provided.

The invention provides a collagen facial mask and a preparation method thereof. The method comprises the following steps of: stirring 1 to 20 mass percent of aqueous solution of collagen and 0.1 to 2 mass percent of aqueous solution of a modifier at the temperature of between 20 and 60 DEG C for reacting for 15 to 45 minutes to obtain stock solution; adding a plasticizer, a functional additive and an antimicrobial growth promoter into the stock solution, and continuing to stir at the temperature of between 20 and 60 DEG C for 30 to 60 minutes to obtain mixed solution; and pouring the mixed solution into a die for forming, and drying at the temperature of between 30 and 60 DEG C for 3 to 10 hours to obtain the collagen facial mask. The prepared collagen facial mask is mainly formed by macromolecular substances extracted from natural animals and plants, safe and effective and does not have toxic or side effect, has the high heat stability, toughness, ductility and adhesion, and can be in fit with skin well and achieve the effects of preserving moisture doubly, softening cutin skin, resisting winkle, whitening the skin, restoring the skin and the like under the assistance of the functional additive; rejected materials of the facial mask are degradable, and do not cause environmental pollution; and the collagen facial mask can be widely applied in the field of daily cosmetics and has the excellent market application prospect.

The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior to seeding with keratinocytes. In other embodiments, increased concentrations of collagen are used to form the dermal equivalent. In still other embodiments, optimized media are utilized to maintain the skin equivalents.

The invention discloses a nano-emulsion medicine for treating foot rot. The grain diameter of the nano-emulsion is in a range of 1-100 nanometers and the nano-emulsion is composed of the following raw materials: 0.1-10.0% of pine tar, 0.1-6.0% of cinnamyl aldehyde, 0.1-6.0% of carvacrol, 0.1-5.0% of camphor oil, 0.01-0.1% of clobetasol propionate, 18.0-35.0% of surfactant, 0-7.0% of co-surfactant and residual amount of distilled water; and the sum of the mass percentages of the components is 100%. The nano-emulsion disclosed by the invention has the functions of dissolving cutin, relieving itching, diminishing inflammation, restraining, partially disinfecting and resisting corrosion, accelerating absorption and the like, and is mainly used for treating animal foot rot. According to the nano-emulsion medicine for treating the foot rot, the solubility of the medicine is increased, the medicinal stability and the biological utilization rate are improved, the dosage of the medicine is reduced, the skin transmission rate is higher than that of common preparations including a medicinal extract and the like, and the cost is low, so that the nano-emulsion medicine has a wide market prospect in a veterinary medicine field.

The invention relates to a method for processing mixtures of carboxylic acids obtained as hydrolysis products of suberin and cutin, particularly suberin and cutin isolated from birch bark, to give oligo- and polyesters, or corresponding ester-ethers, as well as the use of the products thus obtained as lubricants, fuel components, plasticizers, surface active agents, environmentally friendly agents for modifying wood, binders in coatings, adhesives, printing inks and composites, further in various cosmetic applications.

The disclosure relates to compositions and methods of using the compositions to treat keratinous substrates. The compositions provide a water resistant and non-transferable protective barrier on the substrate. The compositions contain at least one polyamine, at least one acid, at least one water-insoluble ingredient, solvent and at least one auxiliary ingredient. The methods for treating keratinous substrates involve contacting the keratinous substrates with the compositions of the disclosure.

Cultures of keratinocyte cells are provided which are free from nonautologous fibroblasts and organ extracts, and which have a high speed of cell amplification for a minimum seeding density. The cultures can be cryopreserved in a buffered isotonic medium containing serum and a cryoprotectant. The cultures are produced by a process that does not involve the use of a feeder layer and organ extracts. A culture medium which can be used contains Medium 199, serum, epidermal growth factor, cholera toxin and / or hydrocortisone, and optionally insulin. A substance for wound healing and for cosmetic applications is derived from cultured human keratinocytes. A non-viable total keratinocyte lysate for use in promoting wound healing is produced by growing keratinocyte cells on a support, detaching the cells from the support, and lysing the detached cells to obtain the lysate which may be frozen and lyophilized. The cells may be grown without using a support to produce the lysate, or to produce a non-viable keratinocyte cell culture lyophilisate or spray dried non-viable keratinocyte cell composition for use in healing wounds.

The invention discloses a compound natural plant extract with a spot-removing function and a preparation method and an application thereof. The compound natural plant extract is prepared by the following raw materials by mass: 50-100 parts of mulberry leaves, 30-60 parts of licorice, 10-50 parts of scutellaria, and 1-35 parts of bearberries. According to the invention, extraction is performed by ultrasonic wave extraction technology which shortens the extraction time, prevents damage of effective components caused by high-temperature heating; the obtained compound natural plant extract can effectively remove aged cutin, lightened spots from the inside to the outside of the body, provide sufficient moisture to maintain skin metabolism, accelerate the spot-removing process, has significant antioxidation effect during spot removal, can remove free radicals in the body, protect skin cells not to be influenced excessively by oxidized free radicals, alleviate skin aging, and eliminate the generation of face wrinkles. Through tests, the compound natural plant extract has no toxic or side effect, and is applicable to the preparation of high-efficient and safe spot-removing wrinkle-resistant cosmetics.

The present invention relates to polyesterases having cutinase and / or suberinase activity obtainable from Coprinus and Trichoderma. The invention further relates to a method for producing the polyesterases, and to polynucleotides, vectors and host cells used therein. The enzymes are useful in hydrolysing cutin, suberin and other polyesters for example in treating agricultural or food raw materials, or wood raw materials, pulp and paper products and waste, and in modifying polyester fibers, or in laundry and dish applications.

The present invention relates to a method for fabricating a microneedle which comprises the steps of spraying a composition into a mould, drying the composition and removal of the dried composition from the mould, thereby forming a microneedle that, when applied to the skin of a subject, pierces the stratum corneum to access the underlying tissue of the subject. The present invention also relates to a method for coating a microneedle which comprises the steps of spraying a composition onto a microneedle and drying the composition at an ambient temperature, thereby forming a coated microneedle that, when applied to the skin of a subject, pierces the stratum corneum to deliver the sprayed material to the underlying tissue of the subject.

The invention relates to a pigment-containing artificial skin detection model and a preparation method thereof. The artificial skin detection model is an epidermal layer structure with activity, which is constructed by compositely inoculating cutin formative cells and melanophores to the surface of a support membrane made from a biodegradable material through culture and comprises a stratum basale, a stratum spinosum, a stratum granulosum and a stratum corneum, and a basilar membrane structure is formed between the epidermal layer and the biodegradable material positioned below the epidermal layer. Compared with the conventional product, the invention can better simulate the pigment components of natural skin and more accurately reflect the whitening and sunscreen effect of cosmetics because of containing the melanophores, nourish the cutin formative cells by using the support membrane made from the biodegradable material as an enderonic layer, control the contraction of the epidermal layer with the strength and enhance the stability of the detection model and has low raw material cost, short manufacturing period and mass production; and in addition, the prepared artificial skin detection model can be directly used for the efficacy detection of the cosmetics and the skin irritation detection of textiles, the cosmetics and chemicals.

A two step method to increase the thickness of human hair in which in Step I, a high pH priming lotion is applied to pre-treat the hair to increase its pH, create an anionic charge and therefore loosen and lift the cuticle layers of the hair. In Step II, an acidic thickening composition is applied on top of the Step I composition to deliver polymers and conditioning ingredients to the hair's polypeptide molecule sites. The Step II components have cationic sites that chemically bond to anionic groups in the hair, making them substantive to the hair wherein they deposit under and around the crevices of the cuticles. The low pH of Step II tightly closes the cuticles, sealing the substantive ingredients to the surface of the hair, providing the hair with increased diameter and long lasting thickness.

The invention relates to the technical field of cosmetics, in particular to a moisturizing composition and application of the same in preparation of the cosmetics. According to the composition, betaine, amino acid, allantoin, oat beta-glucan, oligomerized hyaluronic acid, nicotinamide, ceramide, repairing bioactive peptide and D-panthenol are compounded reasonably. Through triple barrier repairing of skin corium layers, basilar membranes and skin cuticulae, the composition can have good effect of increasing skin moisture content and reducing skin moisture loss. The effect is improved remarkably as compared with the effect of the individually-used components or conventional moisturizing compositions. In a proper ratio, the synergistic effect is achieved through compounding of the components, and accordingly, the moisturizing effect is improved. Experiments show that the moisturizing composition can increase the skin moisture content to 98.19% within 30 minutes, and the skin moisture content can be kept increased by above 70% after two hours.

The invention relates to exfoliating lip balm containing frosted particles. The exfoliating lip balm is characterized by comprising 1.5%-15.0wt% of frosted particles with the particle size of 75-750 microns, wherein a melting point or a softening point of the frosted particles is above 60 DEG C, and the frosted particles can be edible sugar crystals or frosted natural plant particles, or a mixture of the edible sugar crystals and the natural frosted plant particles. The exfoliating lip balm has the beneficial effects of effectively removing dry peeling waste cutin on lips and moisturizing the lip skin simultaneously.

Provided are: a skin-protecting agent and an external preparation for skin protection, which not only synergistically work in combination with a plant polysaccharide but also has an effect of promoting the production of glycerol derived from Staphylococcus epidermidis, which is a skin resident bacterium useful on the skin, and the production of antimicrobial peptides derived from skin epidermal keratinocytes and exhibits excellent effect of improving the touch feeling when applied to the skin. More specifically, the present invention provides a skin protective agent and an external preparationfor skin protection, which comprise a lactic acid bacterium belonging to the genus enterococcus.

The invention belongs to the field of cosmetics and particularly discloses acne-removing composition and an application thereof to cosmetics. The acne-removing composition is prepared from components in parts by mass as follows: 0.1-0.5 parts of a vitamin A palmitate active matter, 0.1-1 part of an azelaic acid active matter, 0.1-1 part of a salicylic acid active matter and 0.1-1 part of an Asiatic pennywort herb extract, wherein the vitamin A palmitate active matter, the azelaic acid active matter and the salicylic acid active matter adopt active matters prepared by coating vitamin A palmitate, azelaic acid and salicylic acid respectively. The skin care composition can well penetrate skin surface layers to be absorbed and enter deep layers; all the components are matched in a specific proportion, and multiple contained effect ingredients are blended and cooperate with one another, so that the composition can play comprehensive roles in stripping aged cutin, dredging pores, inhibiting bacteria, diminishing inflammations, controlling oil, promoting metabolism, clearing pigmentation caused by acne and has the excellent acne removal and skin care effect.

Described herein is a granulated dry composition comprising at least one non-elastomeric polyorganosiloxane, agglomerated onto solid carrier particles. The granulated dry compositions can be used as a dry cleanser for keratinous substrates with high speed of absorption of body fluids together with improved sensory feel and release of care agents.

The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and / or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.

The invention provides a lycium ruthenicum mill moisturizing and whitening cream and a preparation method thereof. The lycium ruthenicum mill moisturizing and whitening cream has the functions of effectively moisturizing and replenishing water, softening cutin, removing freckles and whitening as well as permeating and repairing, remarkably improves the inherent ageing of the skin, prevents the problems of wrinkles, spots and the like of the skin, has the effects of promoting the cell growth, absorbing the ultraviolet radiation, resisting the ageing and arousing the skin vigor, so as to enable the skin to have the moisturizing feeling and the rich gloss, and is excellent in coating feeling and absorption effect. The lycium ruthenicum mill moisturizing and whitening cream is made from pure natural materials, pigment is not added into the cream, and the cream does not contain alcohol, so that the cream is mild without stimulation and free from side effects.

A heat-resistant cutinase and its coding gene and expression belong to the technical field of bioengineering. The present invention provides a bacterial cutinase different from fungal cutinase, its encoding gene and expression system, including extracting the total DNA of Thermobifida fusca WSH03-11, designing primers, and PCR amplification to obtain the gene encoding heat-resistant cutinase, It has the nucleotide sequence shown in SEQ ID NO: 1, the full length is 906 nucleotides, and it encodes 301 amino acids. The plasmid pET20b(+) is used as the expression vector, and E.coli BL21 Rosetta(DE3)PlysS is used as the expression vector. The host can realize the high-efficiency expression of the heat-resistant cutinase gene. This cutinase has good thermal stability and has a good hydrolysis effect on cutin, triglyceride and various soluble synthetic esters, and can be widely used in textile, detergent and other industries.

The invention relates to a non-ionic composition used for removing keratin. The non-ionic composition comprises the following components by weight percent: 0.5-5% of non-ionic polyurethane dispersion liquid, 0.5-5% of non-ionic emulsifier, 0.5-5% of plant extract, 5-20% of moisturizer and the balance of deionized water and additive, wherein the non-ionic emulsifier is polyethylene glycol-240 / hexamethylene diisocyanate copolymer dual-decyl tetradecane alcohol polyether-20 ether; active ingredient in the plant extract is gallogen. According to the non-ionic composition, the non-ionic polyurethane dispersion liquid is used as a film-forming agent to be twisted, the non-ionic emulsifier is used for thickening, non-ionic safe raw material is adopted, feeling is close to skin, a zwitterion complex doe not need to be formed, matrix with low pH value is not needed, and the non-ionic composition is safe, non-irritation, bright white in appearance, smooth and elastic, good in use experience feeling, obvious in immediate effect, moderate and safe, and has the effect of softening the keratin for a long time.

The invention provides a moisturizing co-transportation nano composition and a preparation method and application thereof, and belongs to the technical field of cosmetics. The moisturizing co-transportation nano composition contains the following components in mass percentage: 0.1-10% of physiological lipid, 0.2-10% of an emollient, 0.5-25% of a moisture absorbent, 0.1-6% of biomacromolecules combined with water, 1-20% of liquid grease, 10-50% of emulsifier, 5-30% of co-emulsifier, 0.01-1% of preservative and the balance of water; and the particle size of the moisturizing co-transportation nano composition is 10-500nm. According to the invention, multiple active components with different moisturizing mechanisms are enveloped in a same nano carrier, and therefore, the transdermal co-transportation and cooperated moisturizing effect of multi-target multi-mechanism moisturizing active components is realized, and the dual effects of skin moisturizing and cutin barrier repair are achieved.

The invention discloses an all-natural bee pollen facial mask paste and a production method thereof. According to weight percentage, the component raw materials include: 33-38% of wall-breaking rape pollen, 50-55% of rape honey, 7-9% of fresh royal jelly and 4-6% of pearl powder. According to the all-natural bee pollen facial mask paste and the production method thereof, effects of the normal facial mask products of separating air, infiltrating and softening cuticles, promoting skin blood circulation, tightening skins, removing surplus grease and ageing cutins are kept, facial alimentation absorption is enhanced, natural elasticity and gloss of skins are recovered, more importantly, side effects of the normal facial mask products cannot be generated, and the all-natural bee pollen facial mask paste has good protection effect for faces.

The present invention relates to a cosmetic composition and method for making up and / or enhancing the appearance of a keratinous substrate, comprising at least one supramolecular polymer, at least one detackifying ingredient which is a hyperbranched functional polymer and at least one fatty phase ingredient(s). The compositions of the present invention may optionally contain at least one wax and at least one colorant.

The invention relates to the field of commodities, specifically to a moisture-retaining whitening face cream. The moisture-retaining whitening face cream comprises the following substances by weight: 5 to 8 parts of glycerin, 3 to 5 parts of aloe essence, 5 to 8 parts of green tea seed oil, 8 to 15 parts of pearl powder, 3 to 5 parts of vitamin E acetate, 2 to 5 parts of lecithin wax, 5 to 8 parts of candelilla wax, 8 to 15 parts of refined shea butter, 8 to 20 parts of refined coconut oil, 3 to 8 parts of vitamin B, 1 to 5 parts of stearoxyl trimethyl silane, 3 to 15 parts of hyaluronic acid, 5 to 15 parts of micro walnut powder, 5 to 8 parts of alga extract, 8 to 15 parts of molecular distillation monostearin, 10 to 15 parts of olive oil, 3 to 8 parts of arbutin and 3 to 8 parts of squalane. The moisture-retaining whitening face cream provided by the invention is rich in abundant vitamins, protein and collagen, can effectively retain moisture, supplement water and soften cutin, and is capable of promoting metabolism, activating skin cells, improving blood circulation and accelerating melanin decomposition and excretion, thereby reducing deposition skin pigment and whitening the skin.

The invention relates to the field of cosmetics and provides a co-conveying nano composition of phenylethyl resorcinol. The co-conveying nano composition comprises phenylethyl resorcinol, other skin whitening active components, a nano medicine carrier as well as solvent complex lipid and water, wherein the phenylethyl resorcinol accounts for 0.1-10% of the total mass of the co-conveying nano composition; the other skin whitening active components comprise at least one of an antioxidant, a cutin peeling type active substance, a melanosome transferring inhibition active substance, an anti-glycation active substance and an anti-allergic agent; the nano medicine carrier comprises raw materials of an emulsifier, a Anti-allergic agent and polyhydric alcohols. Due to compounding of different skinwhitening components and carrying of the nano medicine carrier, a remarkable synergetic effect can be achieved, irritation of high-concentration phenylethyl resorcinol can be remarkably reduced, andthe co-conveying nano composition is good in stability, excellent in skin whitening effect, good in water solubility, good in skin permeability and widely applicable to cosmetics.

The invention provides a mixed cultivation method of keratinocyte and melanocyte comprising: breaking the skin sample reserving epidermal layer and at least part of corium layer, cold digesting by pancreatin; collecting deposition organization; heat digesting by I type collagenase, collecting cells; primary inoculating, culturing in KGM-Gold medium; subcultring to the cells merge, culturing in KGM-Gold medium to the cells differentiate and stratify; collecting the formed skin sheet. The mixed cultivation method of keratinocyte and melanocyte uses the medium only for skin keratinocyte and melanocyte with which can avoid pollution of the other cells, and can get skin sheet including functional melanocyte and distributing uniformly. The mixed cultivation method of keratinocyte and melanocyte can get large area of skin sheet from quite small area of autologous sample, solve the problem of shortage of the skin source at skin grafting for the patient with large-area skin diseases, and apply in skin diseases of pigment deficiency such as leucoderma and so on.

The invention discloses an anti-aging cosmetic and a preparation method thereof. The anti-aging cosmetic comprises the following components which are, by mass percentage, 10-20% of spirulina phycocyanin, 1-2% of haematococcus pluvialis extract, 2-5% of vitamin E, 5-8% of prinsepia utilis royle oil, 25-35% of oil phase raw material and 30-55% of aqueous phase raw material; and the sum of the mass percentages of all the components is 100%. The oil phase raw material is melted and fully evenly stirred, the aqueous phase raw material is heated and sterilized with stirring, the oil phase raw material and the aqueous phase raw material are evenly dispersed to be emulsified, the spirulina phycocyanin, the haematococcus pluvialis extract, the vitamin E and the prinsepia utilis royle oil are added, natural cooling is performed after uniform stirring, and the anti-aging cosmetic is obtained. The anti-aging cosmetic is high in permeability and can improve cutin degeneration and have effects of moisture preservation and anti-cracking. Besides, the anti-aging cosmetic is good in safety, non-toxic and free of side effects to the human body and has no stimulation effect on the skin of the human body.