83 results about "Azelaic acid" patented technology

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

This invention provides a novel topical composition containing azelaic acid. [Solution] A two-layer topical composition containing (A) azelaic acid and (B) a surfactant.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The invention discloses a method for directionally preparing high-purity azelaic acid from oleic acid based on a micro-channel reactor, which comprises the following steps: mixing oleic acid and hydrogen peroxide dissolved with a catalyst, and feeding the mixture into the micro-channel reactor for oxidative cracking reaction to obtain oxidation liquid mainly containing the azelaic acid and the oleic acid; standing and layering the oxidation liquid to obtain a water phase A and an oil phase A; hot water is introduced into the oil phase A containing the nonanoic acid and the azelaic acid for extraction and liquid separation, and a water phase B and an oil phase B are obtained; fractionating the oil phase B to obtain high-purity nonanoic acid; cooling and crystallizing the water phase B to obtain a crude azelaic acid product, and melting and evaporating the crude product to remove moisture to obtain high-purity azelaic acid. Based on the microchannel reactor, hydrogen peroxide is used as an oxidizing agent, oleic acid double bonds can be directionally oxidized through a catalyst system, oleic acid is directly oxidized and cracked into nonanoic acid and azelaic acid in a short time, the reaction efficiency can be greatly improved, the reaction time can be shortened, and the use of a solvent and a phase transfer catalyst is avoided; the method has the advantages of high selectivity, high safety and remarkable environmental protection.

To provide an azelaic acid derivative capable of inhibiting stimulation of skin by a skin external preparation applied thereto.SOLUTION: The azelaic acid derivative is represented by AO-C(=O)-R-C(=O)-OA (formula 1) or BO-C(=O)-R-C(=O)-OA (formula 2). The skin external preparation contains active agents, oil-based agents and water-based agents, where the azelaic acid derivative is contained as an oil-based agent. In the formulas 1 and 2, R is a C7 linear hydrocarbon group, A is represented by the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group, and B is hydrogen or the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group.SELECTED DRAWING: None

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The invention discloses composite hydrogel containing azelaic acid and a preparation method of the composite hydrogel, and belongs to the technical field of skin medicines.The azelaic acid is loaded and free azelaic acid is fixed through a layered structure of Ca / LDH powder, and then polymerization modification is conducted through dodecyl methacrylate, so that the composite hydrogel can be firmly smeared on the skin and is prevented from being scoured by sweat, and the skin care effect is good. Moreover, the Ca / LDH powder has an ion exchange characteristic between layers, so that a slow release effect on azelaic acid can be achieved; encapsulated menthol exists in the composite hydrogel containing azelaic acid, the encapsulated menthol is used for clathrating menthol through the clathration of a chitosan / cyclodextrin encapsulation carrier, and after clathration of the chitosan / cyclodextrin encapsulation carrier, a compact crystal structure of the carrier and the cavity clathration of cyclodextrin form a double barrier, so that the composite hydrogel containing azelaic acid has a good barrier effect. Contact between menthol and outside air and temperature is isolated, and volatilization loss of menthol is greatly reduced.

The invention relates to the technical field of synthesis of plasticizers for polyvinyl chloride resin, and discloses azelaic acid di (2-propyl heptyl) ester and a preparation method and application thereof, and the preparation method comprises the following preparation steps: putting azelaic acid, 2-propyl heptanol, a 2-propyl heptanol derivative and deionized water into a reaction kettle, and uniformly mixing to obtain a mixture a; raising the temperature of the mixture a, keeping the temperature, continuously raising the temperature, adding a catalyst, raising the temperature again, carrying out esterification reaction, terminating the reaction, filtering and collecting the catalyst to obtain a mixture b; the preparation method comprises the following steps: mixing a mixture A and a mixture B, cooling the mixture B, adding caustic soda liquid into the mixture B, carrying out water washing neutralization, stirring, standing for layering, discharging water to collect a product, and carrying out vacuum evaporation dehydration on the product to obtain the di (2-propylheptyl) azelate as the plasticizer of the PVC material, so that the mechanical properties of the PVC material can be improved, and the di (2-propylheptyl) azelate is not easy to migrate and volatilize.

The invention discloses bio-based resin capable of being recycled in a closed-loop mode and a preparation method and application of the bio-based resin. According to the resin material, bio-based polybasic acid serves as a raw material and is mixed with 4-carboxyphenylboronic acid, then the mixture and ethylene glycol diglycidyl ether are subjected to an epoxy ring-opening reaction to prepare a bio-based monomer with the end group being boric acid, and the resin is prepared after the monomer is subjected to cross-linking polymerization. Wherein the bio-based polybasic acid is azelaic acid, sebacic acid, Brazil acid, acrylic abietic acid, eleostearic acid anhydride, maleated rosin and the like. The end group of the bio-based monomer is boric acid bonds, and small molecule amine is subjected to catalytic dehydration to form dynamic boric acid ester, so that the monomer is cross-linked to prepare a material with closed-loop recovery, shape memory and self-repairing performance, and the material has wide application prospects in the fields of 3D printing, flexible sensors and friction generator materials.

Biobased dielectric coolants and methods for making diverse high-quality biobased dielectric coolants using carboxylic acid and / or dicarboxylic acids produced from ozone cracking of lipids. The method can include reacting a fatty acid with one or more alcohols, diols, and / or triols to esterify the fatty acid to form esters having a kinematic viscosity @ 40° C. of less than 15 mm2 / s, according to ASTM D 445. The carboxylic acids and dicarboxylic acids can be nonanoic acid, malonic acid, propanoic acid, hexanoic acid, and / or azelaic acid, and can be derived from the oxidation of one or more lipids by ozone cracking.

The application provides a Candida viswanathii CATH2402, the preservation number of which is CCTCC NO: M 20241166, and also provides application of the aforementioned Candida viswanathii in fermentative production of azelaic acid, and a production method of azelaic acid. The Candida viswanathii CATH2402 can utilize various substrates to fermentatively produce azelaic acid, and has high tolerance to the product azelaic acid, thereby significantly improving the yield of azelaic acid by biological method, and having the potential for industrialized scale production.

It relates to a composition, the use of the composition for preparing a topical external formulation or a cosmetic, and a method for preparing the composition. The composition comprises a linear saturated dicarboxylic acid and a polyaspartic acid or derivatives thereof, wherein the content of the polyaspartic acid or derivatives thereof is greater than or equal to 0.01% based on the total weight of the composition. The solubility of the linear saturated dicarboxylic acid (e.g., azelaic acid) in aqueous solutions can be increased by using the linear saturated dicarboxylic acid (e.g., azelaic acid) in combination with the polyaspartic acid or derivatives thereof. It can thus have improved skin permeability, for example when used in a cosmetic, thereby exerting its efficacy to a greater extent.

The invention relates to a method for synthesizing azelaic acid and nonanoic acid through ozone oxidation by using a mixed solvent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: S1, carrying out conjugation treatment on cottonseed oleic acid, a metal oxide catalyst and maleic anhydride or acrylic acid, and then carrying out molecular distillation to obtain high-purity oleic acid; s2, mixing oleic acid with an acetic acid-low carbon alcohol mixed solvent, and sequentially carrying out pre-oxidation and deep oxidation in a tank reactor and a micro-channel reactor to obtain an odorous oxide; s3, adding hydrogen peroxide, and cracking under an acidic condition to obtain a lysate; and S4, crystallizing and separating azelaic acid, and carrying out molecular distillation on mother liquor to recover the azelaic acid and the solvent. Through raw material pretreatment and the synergistic effect of the mixed solvent and the combined reactor, side reactions are reduced from the source, so that the possible problems of low product purity, low reaction efficiency, high solvent consumption and the like in the traditional process are solved. The method is helpful for realizing higher yield and purity of the target product and promoting the cyclic utilization of the solvent, and the process flow is more green and economical.

The invention discloses supramolecular skin-tendering essence and a preparation method thereof, and relates to the technical field of cosmetic preparation, and the supramolecular skin-tendering essence comprises the following components in percentage by mass: 0.5%-2% of supramolecular azelaic acid, 0.5%-2% of supramolecular salicylic acid, 2%-8% of butanediol, 0.65%-2.6% of arginine, 2%-8% of a humectant, 0.33%-1% of a thickener, 2.2%-6.8% of a preservative and a proper amount of water. The thickening agent is prepared from sodium polyacryloyldimethyl taurate and a sphingomonas fermentation product extract according to the mass ratio of (0.3 to 0.85) to (0.03 to 0.15). The supramolecular skin tendering essence disclosed by the invention is excellent in stability and good in water solubility.

This invention belongs to the field of cosmetic research technology, specifically relating to a composition containing ultramicrovesicles, its preparation method, and its uses. The composition comprises the following components by weight: 0.01–30.0 parts of animal umbilical cord extract, 0.001–5 parts of a mixture of pro-xylene and azelaic acid, and 0.1–10 parts of niacinamide; the mass ratio of pro-xylene to azelaic acid in the mixture is 2–3:2–3. This invention combines umbilical cord extract ultramicrovesicles, the pro-xylene and azelaic acid mixture, and niacinamide to achieve a synergistic effect, resulting in better and more comprehensive efficacy in three dimensions: anti-wrinkle and firming, whitening and brightening, and soothing and repairing after application to the skin.

The invention relates to a compound preparation for preventing and treating tobacco mosaic disease and application thereof. Aiming at the problems that chemical control easily causes pesticide residues, biological control takes effect slowly and is unstable, the threshold of a gene editing technology is high and the like in the existing tobacco mosaic disease control technology, the invention provides a medicament compounded by azelaic acid and beta-aminobutyric acid according to a molar ratio of 1: (2-10). According to the agent, antioxidant enzyme systems such as SOD (superoxide dismutase), CAT (catalase) and POD (peroxidase) in tobacco plants are synergistically activated, and meanwhile, SAR (synthetic aperture radar) and SA / ABA double-signal channels are triggered, so that the self-defense capability of the plants is Experiments show that the SOD activity is improved by more than 40% after transplanting for 30 days after treatment by the medicament, and the CAT activity is improved by more than 125% after 60 days, so that the morbidity of the tobacco mosaic disease is obviously reduced, the disease index in 30 days is lower than 1.0, and the morbidity in 60 days is reduced by more than 10% compared with that of a control group. The method is easy and convenient to operate, environmentally friendly and free of residual risk, achieves the dual effects of early-stage rapid inhibition and long-term continuous control, and is efficient and safe in tobacco virus disease prevention and treatment.

The invention discloses a high-concentration azelaic acid acne-removing soothing emulsion, and belongs to the technical field of medicines and skin care products. The method successfully breaks through the technical bottleneck that the solubility of azelaic acid in a conventional water-oil system is extremely low (generally 1t; 1%). According to the invention, 13-19% high-mass-fraction stable loading of azelaic acid can be realized, the system is still kept in a uniform and transparent liquid state at room temperature and after high and low temperature circulation, no crystal is separated out, and the physical friction stimulation of azelaic acid solid crystal particles to the skin in the traditional formula is eliminated. Meanwhile, the bisabolol, capryloyl glycine and other components contained in the system have an instant soothing effect, chemical irritation of azelaic acid can be reduced, and skin tolerance and use comfort of the product are remarkably improved.

The application discloses a kind of eight treasures ten kinds of herbal extract compound active ingredient hair growth liquid and preparation method thereof, belong to the technical field of cosmetics.The hair growth liquid includes basic maintenance type, standard maintenance type, strengthening maintenance type three gradient formulations and scalp special derivative formulation, each formulation takes eight treasures ten kinds of composite herbal extract as core, is matched with active ingredient of promoting maintenance synergism.The active ingredient of promoting maintenance synergism includes bispyrimidine active substance, polypeptide component and adenosine, cooperates with eight treasures ten kinds of composite herbal extract, can realize hair follicle maintenance, hair tough and hair follicle nourishing function.Each formulation takes basic matrix, texture adjustment and soothing component, mild antiseptic system as auxiliary, product pH value is controlled at 5.0~6.5, and the sum of the weight percentage of each component is 100%;Three gradient formulations are mild and non-irritating, do not contain artificial essence, can be simultaneously applied to scalp, hairline, eyebrow and eyelash parts, and scalp special derivative formulation can selectively add mint component and azelaic acid, and is limited to scalp use only.The preparation method includes eight steps of raw material preparation, water phase preparation, oil phase mixing and emulsification, cooling feeding, pH value adjustment, auxiliary component addition, filtering defoaming and filling finished product in sequence.The hair growth liquid can be adapted to sensitive skin and various skin conditions, can nourish hair follicle, improve hair growth microenvironment, can improve hair thinning, fine and soft, easy to fall off, easy to break phenomenon, material body nature is stable, refreshing and not sticky, long-term storage stability is good, can be adapted to industrialization mass production and large-scale application and market promotion, and formulation gradient is clear, and strong expandability can meet multiple use requirements.

The present invention relates to a composition in the form of an oil-in-water (O / W) emulsion, in particular a cosmetic composition, comprising: (i) at least 5% by weight of azelaic acid, the organic or mineral base salts thereof, the solvates thereof, or mixtures thereof. relative to the total weight of the composition, (ii) at least one apolar oil, (iii) at least one polyol of formula (I), (iv) less than 1% by weight of a polar oil relative to the total weight of the composition, or said composition is free of polar oil. The present invention also relates to a non-therapeutic cosmetic process for caring for keratin materials, in particular the skin, comprising the topical application to these keratin materials of a composition according to the invention, or to the use thereof for caring for the skin.

The present invention relates to an advanced dressing in the form of a collagen sheet containing chitosan and azelaic acid microspheres functionalized with ozonized oil loaded on mesoporous silica. In addition, the present invention relates to a process for producing the advanced dressing and use of the advanced dressing in treating skin and mucosal wounds.

This invention provides a composition with anti-inflammatory, acne-reducing, and oil-controlling effects, and its preparation method, comprising active functional components and excipients; wherein the active functional components are tea tree oil, benzoyl peroxide, azelaic acid, quaternary ammonium salt-73, niacinamide, zinc gluconate, retinaldehyde, salicylic acid, licorice extract, purslane extract, capryloyl glycine, acetylglucosamine, and asiaticoside; the excipients include skin conditioning agents, moisturizers, nonionic emulsifiers, and skin-nourishing agents. This invention, through targeted synergistic system design, covers the entire pathogenesis mechanism of acne, achieving synergistic effects of antibacterial acne reduction, oil control, keratinization unblocking, anti-inflammatory repair, and microecological balance; simultaneously, through gradient feeding, liquid crystal emulsification, and low-temperature activation locking preparation methods, the stability of active ingredients is preserved to the greatest extent, solving the industry pain points of traditional acne products where efficacy and gentleness cannot be simultaneously achieved, active ingredients are easily deactivated, and acne is prone to recurrence. It can be widely applied to the preparation of various acne-reducing and oil-controlling skin care products.

This invention discloses an oleic acid oxidative cracking catalyst, its preparation method, and its application, belonging to the field of catalyst preparation technology. The catalyst for the oxidative cracking of oleic acid to azelaic acid is prepared by: uniformly mixing phosphotungstic acid with an organic onium salt, and then ball milling the mixture in a ball mill jar. The preparation method is simple, generates no waste, and produces a catalyst with high yield and high activity. In the process of oleic acid cracking to azelaic acid, the conversion rate of oleic acid reaches 100%, and the selectivity of azelaic acid reaches 96%.

The application provides an application of azelaic acid in promoting seed germination and / or plant growth, and belongs to the technical field of plant growth regulation. The application not only provides the application of azelaic acid in promoting seed germination and / or plant growth, but also provides a method for promoting seed germination and / or plant growth. The seed is treated with an azelaic acid solution with a concentration of 0.1-1.0 mM before sowing. The results of examples show that the azelaic acid can effectively improve the germination rate of the seed under salt stress and normal conditions, shorten the seed germination time, promote the hypocotyl growth and root growth of seedlings, and relieve the adverse effects of salt stress environment on seed germination and plant growth.

This utility model discloses a pipeline reactor for the preparation of azelaic acid, belonging to the field of azelaic acid preparation technology. It aims to solve the problems in the existing technology where, in the later stages of azelaic acid preparation, the product concentration is high, leading to sedimentation, reduced flow rate and volume, and insufficient production efficiency. The reactor includes a pipe body, a base plate, and a vibration assembly. Helical blades are placed inside the pipe body, and the vibration assembly is fixedly installed on the pipe body. A pipe cap is threaded onto one end of the pipe body, and multiple sets of injection pipes are installed through the pipe cap. A discharge pipe is installed at the end of the pipe body away from the pipe cap. This pipeline reactor for azelaic acid preparation, through the vibration assembly, facilitates the provision of excitation force to the pipe body, thereby preventing sedimentation at high product concentrations, ensuring product flow rate and volume, and guaranteeing production efficiency. Furthermore, the lifting plate and chute prevent significant overall displacement of the device, while a third vibration damping pad absorbs vibration.

The invention belongs to the field of new daily chemical materials, and discloses a multi-target composition for synergistically tightening pores and controlling oil, which comprises the following components by weight: 5-10 parts of dipeptide-15; 0.5 to 1 part of acetyl tetrapeptide-5; and 0.1 to 2.5 parts of an azelaic acid derivative. The composition adopts the dipeptide-15, the acetyl tetrapeptide-5 and the azelaic acid derivative as active components, and the three components have a synergistic effect, so that the effect of shrinking pores is achieved. Meanwhile, the invention further provides application and cosmetics of the composition.

The application provides a preparation method of an electrode foil, comprising the following steps: providing an unformed foil, wherein the unformed foil comprises an aluminum foil substrate and an aluminum powder sintering layer which is combined on at least one surface of the aluminum foil substrate; sequentially performing primary formation, secondary formation, tertiary formation, quaternary formation and quinary formation on the unformed foil; wherein the formation solution of the primary formation, the secondary formation and the tertiary formation is an aqueous solution containing boric acid, citric acid and citrate or azelaic acid and azelaic acid salt, adipic acid and adipic acid salt; and the formation solution of the quaternary formation and the quinary formation is an aqueous solution containing boric acid and ammonium carbonate or ammonium pentaborate. The electrode foil prepared by the preparation method has a high specific capacity.

The invention provides a method for determining the inclusion rate of cyclodextrin inclusion azelaic acid, the drug loading capacity and the content of free azelaic acid, and the method comprises the following steps: taking a cyclodextrin inclusion azelaic acid sample, adding a first solvent, and extracting to obtain a free azelaic acid solution to be detected; taking the cyclodextrin inclusion azelaic acid sample, adding a second solvent, heating and extracting to obtain total azelaic acid liquid to be detected; determining the standard substance of the azelaic acid, the free azelaic acid to-be-detected solution and the total azelaic acid to-be-detected solution by adopting high performance liquid chromatography to obtain a standard substance chromatogram of the azelaic acid, a chromatogram of the free azelaic acid and a chromatogram of the total azelaic acid; and obtaining the content of free azelaic acid and total azelaic acid according to the chromatogram, thereby calculating the inclusion rate and drug loading capacity of the azelaic acid. According to the method, the inclusion rate, the drug loading capacity and the free content of cyclodextrin inclusion azelaic acid are directly and synchronously measured in a single chromatographic analysis system for the first time, the result is accurate and reliable based on chromatographic quantification, and system errors caused by a traditional separation method are avoided.

The invention discloses an azelaic acid oiling agent as well as a preparation method and application thereof. The preparation method of the azelaic acid oiling agent comprises the following steps: S1, mixing oleic acid and triglyceride, introducing mixed gas of ozone and oxygen under a stirring condition, and reacting at 20-30 DEG C for 8-14 hours to obtain an intermediate product; and S2, introducing oxygen into the intermediate product at 70-95 DEG C, and reacting for 6-10 hours to obtain the azelaic acid oiling agent. According to the preparation technology disclosed by the invention, mutual dissolution of azelaic acid and oil is realized, and the prepared azelaic acid oil agent has the effects of relieving inflammation and protecting a pigment barrier, can be used for preventing and repairing acute and chronic light injury, especially plateau light injury, and can be used for relieving inflammation and color sedimentation and promoting fading of inflammation and color sedimentation. The traditional Chinese medicine composition can also be used for treating and preventing acute and chronic dermatitis and eczema skin diseases, and helping to repair and prevent a physical barrier and a pigment barrier of the skin; the product is an oil agent, has moistening and moisturizing effects, is convenient to use, has no obvious irritation and has light side effects.

The invention discloses a micro-ecological skin-tendering composition, skin-tendering shower gel and application, and relates to the technical field of cosmetics. The micro-ecological skin tendering composition is prepared from the following components: a moisturizing composition, an oil-control antibacterial compound acid composition and a grease balance protection composition, the moisturizing composition is selected from one or more of glycerol, propylene glycol, butanediol, pentanediol, PEG-8 (Polyethylene Glycol) and trehalose; the oil-control antibacterial composite acid composition is selected from two or more of salicylic acid, tartaric acid, lactic acid and azelaic acid. According to the micro-ecological skin-tendering composition, the skin-tendering shower gel and the application provided by the invention, in the micro-ecological skin-tendering composition, through the synergistic effect of the moisturizing composition, the oil-control antibacterial compound acid composition and the grease balance protection composition, the optimal balance of mildness and efficacy can be realized. The skin-tendering shower gel applying the micro-ecological skin-tendering composition is mild and clean, and can simultaneously realize the effects of oil control, bacteriostasis, oil control, barrier repair and acne removal.

1. Name of the designed product: packing box (azelaic acid gel). 2. Use of the designed product: for packing products. 3. Design points of the designed product: combination of shape and pattern. 4. Picture or photo best showing the design points: perspective view.