474 results about "Azelaic acid" patented technology

Increased compliance in the use of topical sunscreens is obtained by combining a topical sunscreen agent in a formulation containing an antibacterial medication such as azelaic acid or an antibiotic.

Personal care composition comprising at least one hair growth regulating compound selected from the group consisting of glyceryl dilaurate, apigenin, tetrahydrocurcumin, oleanolic acid, azelaic acid, sulforaphane, canavanine, pyridoxal 5-phosphate, phytic acid, tannic acid, grape seed extract, NG-nitro-L-arginine-methyl ester, benzamidine, sodium butyrate, betulinic acid, polyornithine, polyarginine, fisetin, jasmonates, methyl-jasmonate, cis-jasmone, caffeic acid phenethyl ester, delphinidin, ethyl abietate, esculetin, sorbic acid methyl ester, canaline, N-formyl-methionine, N-formyl-alanine, taurine, palmitoyl carnitine, undecanol, undecylenic acid, rutin, fusidic acid, phenyl pyruvic acid, L-isoleucine, phenyl glycine, silibinin, silymarin, L-ascorbic acid-6-palmitate, N-undecylenoyl-L-phenylalanine, and salts, derivatives and mixtures of any of the foregoing; and a dermatologically-acceptable carrier.

The objetive of the present invention was to enhance the skin whitening effects and blackening prevention effects and supply safe and stable topical agents for dermatological use. For that purpose 4-Hydroxyphenyl-alpha-D-glucopyranoside was combined with auxiliary agents such as ascorbic acid and its derivatives, crude drugs and its extracts, hydroxycarboxylic acid and its salts, oil soluble glycyrrhiza extract, gentian extract, phenol derivatives and their salts, placenta extract, kojic acid and its derivative, glucosamine and its derivatives, azelaic acid and its derivatives, retinol and its derivatives, pyridoxin and its derivatives, tocopherol and its derivatives, chitosan and its decomposition products, caffeic acid derivatives, hydroxycinnamate and its derivatives, Umbelliferae plant extracts, mycelial cultures and their extracts, plant leaves and their extracts.

A method of inhibiting skin darkening whilst inhibiting perspiration in the underarm which comprises incorporating into a antiperspirant composition comprising an astringent salt comprising an aluminium and/or zirconium salt, a triglyceride oil and optionally an active acid comprising an aliphatic dicarboxylic acid, especially C₆-C₁₂ such as azelaic acid, an unsaturated C₁₈ aliphatic carboxylic acid such as a linoleic acid or an hydroxybenzoic acid such as salicylic acid, at a ratio to said astringent salts, x:y, of 1:<4 in which x represents the weight concentration of said triglyceride oil plus 4 times the weight concentration of active carboxylic acid and y represents the weight concentration of said astringent salts. The composition can additionally comprise glycerol and/or a chelating agent for a transition metal.

An improved method and preparation for the treatment of acne and hirsutism comprises topically applying an effective amount of a saw palmetto berry extract, and preferably one or more low irritability constituents that enhance penetration of the extract into hair follicle sebaceous glands. The low irritability penetration aid may be selected from the group consisting of adapalene, tretinoin, tretinoin gel microsponges, retinaldehyde, retinol, tazarotene, beta hydroxy acids (salicylic acid), azelaic acid, and alpha hydroxy acids (glycolic acid) as well as polyolprepolymer-2.

The invention relates to electrolyte of an aluminum electrolytic capacitor, a preparation method thereof and the aluminum electrolytic capacitor. The electrolyte of the aluminum electrolytic capacitor includes the following components by mass: 33.5-82.7% of a main solvent, 4%-20% of an auxiliary solvent, 5%-20% of a solute, 5%-15% of a corrosion remover, 3%-10% of flash point promotion agent, 0.2%-1% of hydrogen elimination agent and 0.1%-0.5% of water-mixture-proof agent, wherein the solute is at least one of isodecyl ammonium sebate, 2-butyl-cork-acid-ammonium, 2- ethyl ammonium oxalate, 5, 6-ammonium sebate, potassium sebate, sebacic acid, azelaic acid, ammonium azelate, ammonium pentaborate and potassium carboxylate with chains with the number of carbon chains as 24-35. Experiments show that the aluminum electrolytic capacitor using the electrolyte has good high temperature resistance, the service life can be 2000 hours under the environment with the temperature high as 135 DEG C, and the service life is longer.

A cosmetic skin-care composition containing as the active principle a depigmentationally active combination of (a) an acidic mixture including (i) at least one alpha-hydroxylated acid or a derivative thereof, with the exception of ascorbic acid, and (ii) at least one compound selected from the group which consists of kojic acid, caffeic acid, azelaic acid, aminobutyric acid, fusaric acid, 5-hydroxy 2-hydroxymethyl-gamma-pyridone, and derivatives thereof, and (b) at least one active component of a plant extract from at least one plant selected from white mulberry, liquorice, skull cap, grapefruit, birch, heather, strawberry tree, bearberry, lemon, lettuce, oarweed, cucumber, ginseng, hop, sweet corn, feverfew, sage, soya, elder, spirulina, lime, ferocious aloe, yukinoshita, bloodwort, hoelen, wood rose, alpha-orizanol, burnet, ginkgo biloba, tanlex VB and Eclipsa alba, with the proviso that when the composition contains kojic acid and a liquorice extract, it contains at least one other plant extract component. The use of said composition for preparing a drug or in a cosmetic method is also disclosed.

This invention relates to a method for achieving a novel solution comprising a high percentage of a piperidinopyrimidine derivative, more particularly minoxidil. The method of the current invention results in a highly effective solution for facilitating hair growth comprising a high concentration of Minoxidil, that is not cosmetically unattractive when applied to a treatment area and that does not cause skin irritation in the treatment area. In another aspect of the invention, said solution comprising high percentage Minoxidil may further comprise co-active ingredients, such as azelaic acid. The present invention also provides a method for stimulating the growth of hair or for preventing hair loss in humans and lower animals.

This invention relates to aluminum electrolytic capacitor and its preparation method, especially relates to aluminum electrolytic capacitor used in flashing light and its preparation method. Its work electrolyte components is that main solvent is ethylene glycol. Secondary solvent is one or mixture N.N dimethyl formamide, N-methyl-2- pyrrolidone, polyethylene glycol octyl phellyl ether and water. The main solute is one or mixture of ammonium benzoate, ammonium sebacate, ammonium pentaborate, azelaic acid hydrogen ammonium, dodecandioic acid ammonium, mannitol. The additive is one of mixture of m-dinitrobenzene, ammonium dibasic phosphate, nitrodracylic acid ammonium and amphi nitryl benzoic alcohol. The capacitor in this invention is good in pressure resistance, the leakage current is little, the slow leakage rally can be used to make flashing light aluminum electrolytic capacitor of rated voltage keep around 330V.

The invention relates to a pharmaceutical composition having the following constituents: azelaic acid, polyacrylic acid, triacylglyceride, propylene glycol, polysorbate, soya lecithin, water and salts. The composition is a hydrogel which is suited for the treatment of rosacea, presbyderma, melasma or skin irritations.

It has been discovered that solid, particulate dicarboxylic acids are useful as diverting agents in methods for acidizing subterranean formations to improve the uniformity of the acid treatments (acid displacement) by diverting acid to intervals of relatively less permeability. Particularly suitable solid, particulate dicarboxylic acids include, but are not necessarily limited to, those insoluble in both aqueous and hydrocarbon liquids, but which are soluble in mutual solvents or alcohol blends. These acids may have melting points of from about 180 to about 300° F. (about 82 to about 149° C.), formula molecular weights of from 146 to 400, and mesh sizes of from about 20 mesh to about 400 mesh (about 841 to about 38 microns). Particular dicarboxylic acids that fit this description include, but are not necessarily limited to, dodecanedioic acid, undecanedioic acid, decanedioic acid, azelaic acid, suberic acid, and mixtures thereof.

Dry dipercarboxylic acid material and methods of using dry dipercarboxylic acid particulates to form novel sterilizing solutions or liquid chemical germicides. The dipercarboxylic acids or organic diperoxygen compounds can be synthesized and isolated as solid powders with an extended shelf life. The powders are also soluble in water for quickly preparing liquid disinfectant solutions, whenever and wherever desired, from a potable water source. The dry dipercarboxylic acid materials are selected from diperglutaric acid, diperadipic acid, diperpimelic acid, dipersuberic acid, and diperazelaic acid. Upon dissolution into water, these compounds have demonstrated the ability to inactivate high numbers of spores, including sterilization of medical equipment in 10 minutes at room temperature.

The present invention relates to a cosmetic or pharmaceutical formulation comprising a hyaluronate crosspolymer and one or more of (a) azelaic acid or an ester thereof; (b) one or more of black cumin seed oil, chaulmoogra oil, magnolia bark extract and manuka oil; and (c) resveratrol or a derivative thereof. Uses of the formulation for skin treatments, promoting collagen production and regulating cellular turnover are also described.

The present disclosure relates to crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and pharmaceutically acceptable solvates thereof. The present disclosure also relates to pharmaceutical compositions comprising the crystalline monoapadisylate and/or heminapadisylate salt of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxyquinolin-2(1H)-one, and to methods of treatment comprising these pharmaceutical compositions.

The invention belongs to the field of cosmetics and particularly discloses acne-removing composition and an application thereof to cosmetics. The acne-removing composition is prepared from components in parts by mass as follows: 0.1-0.5 parts of a vitamin A palmitate active matter, 0.1-1 part of an azelaic acid active matter, 0.1-1 part of a salicylic acid active matter and 0.1-1 part of an Asiatic pennywort herb extract, wherein the vitamin A palmitate active matter, the azelaic acid active matter and the salicylic acid active matter adopt active matters prepared by coating vitamin A palmitate, azelaic acid and salicylic acid respectively. The skin care composition can well penetrate skin surface layers to be absorbed and enter deep layers; all the components are matched in a specific proportion, and multiple contained effect ingredients are blended and cooperate with one another, so that the composition can play comprehensive roles in stripping aged cutin, dredging pores, inhibiting bacteria, diminishing inflammations, controlling oil, promoting metabolism, clearing pigmentation caused by acne and has the excellent acne removal and skin care effect.

The invention relates to the technical field of a cooling liquid and particularly relates to a vehicle engine cooling liquid. An additive composition consists of the following components in percentage by mass: 30 to 60 percent of glycol, 0.15 to 0.3 percent of benzotriazole, 0.05 to 0.1 percent of sodium benzoate, 0.5 to 1.5 percent of sebacic acid, 0.1 to 1.0 percent of azelaic acid, 0.5 to 1.0 percent of sodium metasilicate, 0.2 to 0.5 percent of a silicate stabilizer, 0.001 to 0.01 percent of an antifoaming agent, 0.05 to 0.8 percent of potassium hydroxide, 0.002 to 0.006 percent of dye and the balance of deionized water. The vehicle engine cooling liquid adopts a novel mixed formula which uses organic substances as the main materials and uses inorganic substances as the auxiliary materials, has a good anticorrosive effect and a stable performance, has no precipitates, does not comprise substances which pollute the environment and are harmful for human bodies, such as amine substances, nitrite, phosphate and the like, is low in cost, can be widely applied to a vehicle engine cooling system and is suitable to be used in various areas.

The invention relates to acne treatment emulsion, and belongs to the field of cosmetics. The acne treatment emulsion comprises the following components: component A comprising propylene glycol, xanthan gum and first solvent; component B comprising 2-hydroxyethanesulphonic acid hexyl ether, vitamin B6 and second solvent; component C comprising plant extract, azelaic acid derivatives, dendranthema indica (L.) des moul, salicylic acid, ginseng extract, vitamin E and preservative agent. The acne treatment emulsion has the functions of treating acne, whitening and nourishing skin, moisturizing, reducing oil secretion, and promoting cellular metabolism, the effect is obvious, the action is fast, no acne scar is left after healing, and the acne is not easy to relapse; and the acne treatment emulsion is a cosmetic which is used for preventing and treating acne and whitening skin.

The invention provides a nutritional preparation with selective whitening spot-removing efficacy and application thereof in medicinal cosmetics. The nutritional preparation is prepared by compounding of azelaic acid oligopeptide, ascorbic acid oligopeptide, tranexamic acid oligopeptide, retinoic acid oligopeptide, kojic acid oligopeptide, hydroxy acid oligopeptide, ellagic acid oligopeptide and other raw materials, and the oligopeptide is one or a compound of multiple of dipeptide, tripeptide, tetrapeptide, pentapeptide, hexapeptide, heptapeptide, octapeptides, nanopeptide and decapeptide. The medicinal cosmetics prepared form the nutritional preparation are original liquids, water preparations, masks, cream lotion, liquid foundation cream, gel, essence and other preparation forms. The cosmetics are prepared by compounding of the nutritional preparation, penetrating agents and auxiliary materials. The penetrating agents are plant essential oils, azone, carbitol and other medical penetrating agents. The auxiliary materials are thickeners, emulsifiers, packet agents, wetting agents, emollients, flavoring agents, preservatives and solvents which are used as main medicinal raw materials. A large number of clinical trials prove that the medicinal cosmetics prepared form the nutritional preparation have good selective whitening spot-removing and nutritional efficacy for the skin of human body.

The invention discloses a preparation method of a single-component anti-media adhesive, which belongs to the field of an adhesive and comprises the steps of: preparing polyester polyol: esterifying dimer acid, sebacic acid and diglycol in a polyester synthetic kettle; adding phthalandione, azelaic acid and neopentyl glycol to carry out secondary esterification; undergoing polycondensation reaction to obtain the polyester polyol; reacting the prepared polyester polyol with isocyanate and ethyl acetate; adding an aliphatic amine chain extender; and undergoing chain extension reaction to obtain a product which is the single-component anti-media adhesive after the reaction. In the preparation method, the structure of a polyester chain section is designed and a urea-based formic ether chain section unit is introduced, so that the prepared single-component anti-media adhesive has high initial anchorage and resistance to various corrosive contents. Compared with a traditional polyurethane adhesive, the single-component anti-media adhesive has more excellent anti-media performance when used on acid, alkali, and pesticide resistant packing materials.

The invention discloses a separation purification method of azelaic acid, belonging to the separation purification technical field of organic compound, which comprises depressurizing and distilling the oxidation solution obtained by treating ozonation-oxidation decomposition on unsaturated fatty acid to remove solvent and pelargonic acid, transferring left oxidation solution to a film evaporator to be distilled to obtain crude azelaic acid, extracting and recrystallizing the crude azelaic acid to obtain azelaic acid crystal. In the recrystallization of azelaic acid, the low-carbon dibasic acid of C<4>-C<8> in azelaic acid is dissolved in cold water, to be discharged along with crystallization mother liquor, and the left azelaic acid in the recrystallization mother liquor is recovered by the film separator. The obtained azelaic acid is transferred to a rising film evaporator to be dried and dehydrated and the dehydrated azelaic acid is evaporated by film to obtain the azelaic acid. The whole process can confirm the yield of azelaic aicd and obtain high-quality azelaic acid, while the whole system is sealed and the process has better environmental compatibility.

The invention belongs to a composition of four-component lithium complex grease and a preparation method thereof. 12-lithium hydroxyl stearate, lithium azelaic acid or lithium sebacic acid, lithium boric acid and lithium salicylate are added into base oil. Four-component complex lithium prepared by controlling complex saponification temperature and time in a first step, alkali adding temperature in a second step, complex co-crystallization temperature and time and the highest temperature by a two-step saponification process has the advantages of high adhesion property, excellent high temperature leakage resistance, long high-temperature bearing service life, high comprehensive performance and capability of meeting the requirement of the lubricating of high-temperature environment equipment and high-temperature centralized pumping and lubricating. The lithium complex grease of the invention belongs to high-temperature grease of which the dropping point is not less than 260 DEG C and which has the prominent advantages of high adhesion property, excellent high temperature leakage resistance and long high-temperature bearing service life at the temperature of 160 DEG C. Compared with polyurea grease, the lithium complex grease cannot be hardened at a high temperature; and compared with the ordinary two-component or three-component complex lithium, the lithium complex grease has the advantages of high adhesion property, excellent high temperature leakage resistance and long high-temperature bearing service life.

The invention discloses a formation method of a high-specific-volume, high-flexibility and low-electric-leakage electrode foil. The formation method comprises first-grade formation, second-grade formation, third-grade formation, fourth-grade formation and fifth-grade formation of an aluminum foil, wherein the first-grade formation of the aluminum foil is performed in water solution containing azelaic acid and ammonium azelaic acid; the second-grade formation is performed in water solution containing azelaic acid, ammonium azelaic acid and boric acid; the third-grade formation is performed in water solution containing lemons, boric acid and ammonium azelaic acid; and the fourth-grade formation and the fifth-grade formation are both performed in water solution containing boric acid and ammonium pentaborate. The electrode foil manufactured by using the method is high in specific volume, high in bending strength and low in electric leakage; and the quality of the electrode foil is effectively improved.

The present invention relates to process of catalytically oxidizing oleic acid or mixed fatty acid obtained through hydrolyzing animal and vegetable grease with mixed oxidant of ozone and hydrogen peroxide to prepare azelaic acid, and belongs to the field of organic compound preparing technology. By using ozone and hydrogen peroxide as mixed oxidant, phosphotungstic acid as catalyst and quaternary ammonium salt as phase transfer reagent, and through the reaction at 60-70 deg.c and normal pressure and the further reaction at 95-105 deg.c for 8-12 hr, the material oleic acid or mixed fatty acid is oxidized and cracked to prepare azelaic acid.