223 results about "Azelaic acid" patented technology

An anti-oil and anti-acne shower gel, comprising the following raw material components in percentage by weight: 10-18% of a surfactant, 0.3-1% of a thickening agent, 0.5-2% of sodium chloride, 0.05-0.2% of a pH regulator, 0.1-0.6% of azelaic acid, 0.1-0.5% of caprylylglycine, 0.1-0.6% of a plant acaricide, 0.2-2% of a radix sophorae flavescentis extract, 0.01-0.1% of an Epilobium fleischeri extract, 0.1-0.5% of a saccharide isomeride mixture, 0.1-0.5% of sodium ascorbyl phosphate, 0.5-1.5% of a Tremella extract, 0.01-0.2% of a gentian extract, 0.3-0.7% of a preservative, and the balance of water.

The invention discloses an anti-hair-loss composition, preparation thereof and application of the anti-hair-loss composition in hair washing and caring products, and belongs to the field of cosmetic preparation. The method for preparing the anti-hair-loss composition with the good and lasting anti-hair-loss effect comprises the following steps: (1) uniformly mixing arginine and citric acid, then adding diaminopyrimidine oxide, and continuously and uniformly mixing to form a mixture A; (2) uniformly mixing azelaic acid, nicotinamide and butanediol to form a mixture B; (3) uniformly mixing the mixture A, the mixture B, caffeine, a sanguisorba officinalis root extract, a green tea extract and a cacumen biotae extract to obtain the anti-hair loss composition. The anti-hair loss composition prepared by the invention is simple in component and simple in preparation process; the effect is lasting, and the anti-hair loss effect is good.

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The invention relates to the technical field of traditional Chinese medicine research, in particular to a discovery method of a cough relieving and phlegm eliminating quality marker of cough relieving granules and the quality marker. According to the application, the cough-relieving and phlegm-eliminating drug effects of the cough-relieving granules are evaluated by virtue of concentrated ammonia water cough inducing and phenol red excretion tests, plasma pharmaceutical chemistry research of the cough-relieving granules is developed by virtue of a UHPLC-Q-Exactive Plus Orbitrap HRMS technology, and 26 prototype blood-entering components of the cough-relieving granules are analyzed and identified; through network pharmacological analysis of components entering blood, 11 potential active components for relieving cough and eliminating phlegm of the cough-relieving granules are screened, relate to 40 common targets such as IL6, TLR4, STAT3 and the like, and mainly participate in signal channels such as PI3K-Akt, HIF-1, EGFR (epidermal growth factor receptor) and the like; the seven prototype blood-entering components are quantitatively analyzed by utilizing pharmacokinetics. The three compounds of azelaic acid, caffeic acid and vanillin are used as the cough relieving and phlegm eliminating quality markers of the cough relieving granules through effectiveness, transitivity and testability. The research result is of great significance in deeply defining the pharmacodynamic material basis of the cough-relieving granules, optimizing the quality standard and promoting the clinical application of the cough-relieving granules.

Mixed aliphatic-aromatic polyesters having suitable thermal properties and terminal acidity characterised by having a dicarboxylic component comprising at least three saturated aliphatic C4-C24 dicarboxylic acids, their C1-C24 alkyl esters, their salts and their mixtures, azelaic acid and succinic acid always being present.

The invention discloses a high-voltage solid capacitor positive electrode oxide film repairing electrolyte and a film coating process thereof, and belongs to the technical field of solid capacitors. The electrolyte comprises ammonium azelate, azelaic acid, ammonium dihydrogen phosphate, phosphoric acid, a reducing agent, a functional additive, ethylene glycol, deionized water and other components; the electrolyte can effectively repair the positive electrode foil oxidation film when the positive electrode foil oxidation film has defects, and the film coating process comprises the steps of acid pickling pretreatment, electrolyte repair, silane coupling agent treatment, film forming liquid impregnation and curing and the like, according to the invention, the oxidation film on the surface of the positive electrode foil is repaired through the electrolyte, and the uniform and compact protection film is formed through a film coating process, so that the mechanical strength and corrosion resistance of the oxidation film are enhanced, the leakage current value of the capacitor is effectively reduced, and the service life of the capacitor is prolonged. The performance of the capacitor is improved, and the corrosion of the external environment to the oxidation film is isolated.

The invention belongs to the technical field of cosmetics, and particularly relates to azelaic acid liposome as well as a preparation method and application thereof. The invention firstly provides a composition for preparing the azelaic acid liposome. The composition comprises an organic phase composition and a water phase composition which are used for preparing the azelaic acid liposome, the organic phase composition comprises 1, 2-propylene glycol, hydrogenated phosphatidylcholine and cholesterol; the aqueous phase composition includes an aqueous phase medium and azelaic acid. The invention further provides a method for preparing the composition into the azelaic acid liposome by utilizing a 1, 2-propylene glycol injection method, which comprises the following steps: mixing the components in the organic phase composition to obtain an organic phase solution; mixing the components in the water-phase composition to obtain a water-phase solution; and injecting the organic phase solution into the water phase solution for reaction, and finally performing high-pressure homogenization to obtain the azelaic acid liposome. According to the method, organic solvents do not need to be removed in the preparation process, and the obtained product is good in solubility, good in stability and high in safety and has the effects of removing acnes, controlling oil and whitening.

The invention relates to the technical field of cosmetics, in particular to preparation and application of a cyclodextrin-coated azelaic acid oil-control skin-care product. Comprising the following steps: S1, adding deionized water into a mixer, adding a cyclodextrin-azelaic acid inclusion compound, nicotinamide and allantoin, mixing to obtain a water phase, mixing glycerol, caprylic / capric triglyceride, polydimethylsiloxane, polysorbate-80 and tocopheryl acetate to obtain an oil phase, slowly adding the oil phase into the water phase, and shearing and emulsifying to obtain a nanoemulsion; and S2, cooling the nano-emulsion, adding carbomer while stirring, continuously cooling to room temperature, sequentially adding phenoxyethanol, ferulic acid, menthol and essence, adjusting the pH value of the emulsion with triethanolamine, homogenizing, defoaming, disinfecting and filling. By adjusting the proportion of the components in the formula, the skin feeling of the product can be further optimized, so that the product is more comfortable and not greasy, and a lasting oil control effect is provided.

The present invention relates to hydrogel formulations comprising azelaic acid-cyclodextrin complex for use in the treatment of acne.

The invention provides a synthesis method of an absorption enhancer N-(8-[2-hydroxybenzoyl]-amino) sodium caprylate. The method comprises the following steps: dehydrating azelaic acid serving as a raw material to obtain anhydride; the preparation method comprises the following steps: taking 2-aminooctanoic acid as a raw material, reacting with ammonia water to obtain monoamide, concentrating, carrying out Hofmann degradation reaction to obtain an important intermediate 8-aminooctanoic acid, reacting with methyl salicylate in a solvent-free state, and purifying to obtain sodium N-(8-[2-hydroxybenzoyl]-amino) octanoate after the reaction is completed. According to the method, raw materials are easy to obtain, conditions are mild, purification is simple, a high-purity finished product can be obtained, and industrial production is facilitated.

The invention relates to a polyglycerol partial ester obtainable by esterification of a) a polyglycerol mixture, b) poly(hydroxycarboxylic) acid, c) at least one dicarboxylic acid having 6 to 12, preferably 9 to 10, carbon atoms, more preferably selected from azelaic acid and sebacic acid, and d) oleic acid.

The invention discloses a high-stability azelaic acid acne-removing emulsion, and the azelaic acid acne-removing emulsion with long-term stability and high concentration is obtained by using a thickening agent sphingomonas fermentation product which can resist acid and salt at high temperature and normal temperature. The invention also discloses a stability accelerated test evaluation method of the high-stability azelaic acid acne-removing emulsion, in-situ measurement is performed by adopting a Turbiscan stability analyzer, and the stability of the azelaic acid acne-removing emulsion is compared and predicted by replacing a traditional stability test method with key parameters such as a back scattered light change value, a peak thickness, a particle migration rate and the like. Compared with the prior art, the method has the advantages that the stability test process is greatly accelerated, the efficiency is improved by dozens of times, the technical breakthrough not only remarkably shortens the product development period, but also provides a scientific basis for formula optimization of the high-concentration azelaic acid acne-removing emulsion, and the long-term stability and effectiveness of the azelaic acid acne-removing emulsion in clinical application are ensured.

The present invention relates to an advanced dressing in the form of a collagen sheet containing chitosan and azelaic acid microspheres functionalized with ozonized oil loaded on mesoporous silica. In addition, the present invention relates to a process for producing the advanced dressing and use of the advanced dressing in treating skin and mucosal wounds.

The present application provides a kind of cosmetic composition for acne and its preparation method, it is related to the technical field of cosmetics.The cosmetic composition comprises by mass percentage 0.01-2.0% of acacia gum, 0.01-2.0% of sphingomonad ferment product extract, 0.01-10% of exfoliating agent, 0.01-1.0% of oil control agent, 0.001-0.005% of bacteriostatic agent, 0.01-2.0% of anti-inflammatory agent and 0.01-2.0% of soothing and repairing agent; the balance is cosmetic base; wherein the exfoliating agent includes one or more of coated multi-fruit acid, coated azelaic acid and coated salicylic acid; the anti-inflammatory agent includes 100 and 1609; and the soothing and repairing agent includes 100, which solves the technical problems of difficult thickening, insufficient mildness and insufficient refreshing after absorption of acne-removing products.

The invention discloses a preparation method of azelaic acid, which is characterized in that under a solvent-free condition, a reusable supported heteropolyacid salt catalyst is adopted to catalyze oleic acid to oxidize so as to prepare the azelaic acid. The method is characterized in that the supported heteropolyacid salt catalyst is supported phosphotungstate or supported silicotungstate, and the oxidizing agent is hydrogen peroxide. Compared with the prior art, the method has the advantages that the catalyst can be efficiently separated and reused, the production cost is reduced, the reaction process is simple, and the process is clean.

This invention provides a novel topical composition containing azelaic acid. [Solution] A two-layer topical composition containing (A) azelaic acid and (B) a surfactant.

The invention provides application of a compound azelaic acid in preparation of a medicine for preventing and treating sepsis acute lung injury. Animal experiments show that azelaic acid is highly enriched in intestinal tracts and lungs of mice with ketogenic diet and is closely related to the occurrence and development process of sepsis acute lung injury. The compound azelaic acid can obviously inhibit lung inflammatory cell infiltration, inflammatory factor generation and lung cell apoptosis on the animal level, and can be used for preparing the medicine for preventing and treating acute lung injury caused by sepsis.

The invention relates to the technical field of azelaic acid processing, in particular to an azelaic acid cooling crystallization method and equipment, the azelaic acid cooling crystallization equipment comprises a bearing table, a mounting rack, a servo motor, a fixing frame, a reaction kettle, a feeding port and a discharging port, the mounting rack is fixedly mounted on the upper surface of the bearing table, the servo motor is fixedly mounted on one side of the mounting rack, and the fixing frame is fixedly mounted on the other side of the mounting rack; the fixed frame is fixedly mounted on an output shaft of the servo motor, the reaction kettle is fixedly mounted on the inner side of the fixed frame, the feed port is formed in the upper side of the reaction kettle, and the discharge port is formed in the lower side of the reaction kettle. The n-octane layer and the azelaic acid crystallization layer can be sent out from the two outlets through cooperation with the impurity removal assembly, impurities in the n-octane layer on a phase interface are prevented from making contact with an azelaic acid aqueous solution, and the purity of azelaic acid crystallization is improved.

The invention relates to the field of cosmetics, in particular to a hair preparation for killing mites and relieving scalp inflammation and a preparation process. The composition for killing mites and relieving scalp inflammation is prepared from salicylic acid, azelaic acid, a citronella extract, a herba violae extract, a herba houttuyniae / radix scutellariae extract, a solvent, a solubilizer and water, and then the composition is applied to a hair preparation. The composition has excellent acarus killing and anti-inflammatory performance, and the hair composition is endowed with excellent performance.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The invention discloses a method for directionally preparing high-purity azelaic acid from oleic acid based on a micro-channel reactor, which comprises the following steps: mixing oleic acid and hydrogen peroxide dissolved with a catalyst, and feeding the mixture into the micro-channel reactor for oxidative cracking reaction to obtain oxidation liquid mainly containing the azelaic acid and the oleic acid; standing and layering the oxidation liquid to obtain a water phase A and an oil phase A; hot water is introduced into the oil phase A containing the nonanoic acid and the azelaic acid for extraction and liquid separation, and a water phase B and an oil phase B are obtained; fractionating the oil phase B to obtain high-purity nonanoic acid; cooling and crystallizing the water phase B to obtain a crude azelaic acid product, and melting and evaporating the crude product to remove moisture to obtain high-purity azelaic acid. Based on the microchannel reactor, hydrogen peroxide is used as an oxidizing agent, oleic acid double bonds can be directionally oxidized through a catalyst system, oleic acid is directly oxidized and cracked into nonanoic acid and azelaic acid in a short time, the reaction efficiency can be greatly improved, the reaction time can be shortened, and the use of a solvent and a phase transfer catalyst is avoided; the method has the advantages of high selectivity, high safety and remarkable environmental protection.

The present invention relates to an advanced medication containing chitosan and azelaic acid microspheres. The present invention also relates to a process for producing the advanced medication and the use of the advanced medication in the treatment and / or prevention of skin and mucosal lesions.

To provide an azelaic acid derivative capable of inhibiting stimulation of skin by a skin external preparation applied thereto.SOLUTION: The azelaic acid derivative is represented by AO-C(=O)-R-C(=O)-OA (formula 1) or BO-C(=O)-R-C(=O)-OA (formula 2). The skin external preparation contains active agents, oil-based agents and water-based agents, where the azelaic acid derivative is contained as an oil-based agent. In the formulas 1 and 2, R is a C7 linear hydrocarbon group, A is represented by the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group, and B is hydrogen or the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group.SELECTED DRAWING: None

The invention relates to hair-blacking essence and a preparation method thereof. Screening a symbiotic bacterium metabolism extract with small molecule peptide metabolism regulation capability; by combining low-concentration azelaic acid and zinc lactate components, scalp grease oxidation and abnormal proliferation of propionibacterium are inhibited; the expression of IL-10 anti-inflammatory factors is induced, the expression of TNF-alpha and IL-6 is reduced, and the hair follicle microinflammation state is reduced; a Wnt / beta-catenin pathway activator is used for inducing the melanin stem cells to be in a static state; the FGF-2 and the EGF are combined in a micro-dose manner to promote the amplification into precursor cells; mITF regulation peptides and a small amount of trace copper ions are supplemented to induce directional differentiation into mature melanocytes; a microcapsule carrier system with a three-layer structure; the penetration efficiency is improved; antioxidative peptide rich in reduced glutathione, NAD and a promoting factor are used, so that melanocytes are protected from oxidative damage; a coenzyme Q10 type mitochondrial homeostasis regulator is introduced, so that the energy metabolism is improved, the cell aging is delayed, the targeting property is strong, and the effect is accurate.

The invention discloses a gel preparation device which comprises a mounting mechanism, a gel material placing mechanism used for placing a gel material is arranged above the mounting mechanism, and a stirring mechanism used for mixing and stirring the gel material in the gel material placing mechanism is arranged at the rear end of the mounting mechanism. A driving mechanism used for driving the gel material placing mechanism to rotate in the Z-axis direction and enabling the gel material placing mechanism to vibrate in the Y-axis direction is arranged at the top end of the mounting mechanism, a second gear motor is arranged on the driving mechanism, and a second bevel gear is mounted on an output shaft of the second gear motor; and the second bevel gear is engaged with the first bevel gear. According to the device, bubbles generated in the azelaic acid gel process can be effectively removed, the quality of the azelaic acid gel is improved, the pouring and discharging speed of the azelaic acid gel is effectively increased, and the production efficiency is improved.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The invention relates to a preparation method and application of an amphiphilic oil agent for skin care products, and discovers that the amphiphilic oil agent can be prepared from bis-azelaic acid sericin peptide arginine salt, bis-diethyoxyl diethylene glycol cyclohexane 1, 4-dicarboxylate and glycerol carbonate through a specific preparation mode. The amphiphilic oil agent has the characteristics of surface activity and quick-acting permeation assistance, and can promote nutrient substances to quickly enter the skin in a short time of cleaning the skin, so that the effects of cleaning the skin and beautifying and tendering the skin are realized at the same time. Bis-azelaic acid sericin protein peptide arginine salt further formed by the bis-azelaic acid sericin protein peptide is matched with bis-diethyoxyl diethylene glycol cyclohexane 1, 4-dicarboxylate to form a hydrophilic and lipophilic system, and due to the amphipathicity, the system can play a role of a bridge intermediary between intercellular lipid and sebum, so that the effect of inhibiting the sebum is achieved. Therefore, some water-soluble active molecules are helped to realize permeation, and the transdermal absorption rate can be obviously improved.

The invention discloses composite hydrogel containing azelaic acid and a preparation method of the composite hydrogel, and belongs to the technical field of skin medicines.The azelaic acid is loaded and free azelaic acid is fixed through a layered structure of Ca / LDH powder, and then polymerization modification is conducted through dodecyl methacrylate, so that the composite hydrogel can be firmly smeared on the skin and is prevented from being scoured by sweat, and the skin care effect is good. Moreover, the Ca / LDH powder has an ion exchange characteristic between layers, so that a slow release effect on azelaic acid can be achieved; encapsulated menthol exists in the composite hydrogel containing azelaic acid, the encapsulated menthol is used for clathrating menthol through the clathration of a chitosan / cyclodextrin encapsulation carrier, and after clathration of the chitosan / cyclodextrin encapsulation carrier, a compact crystal structure of the carrier and the cavity clathration of cyclodextrin form a double barrier, so that the composite hydrogel containing azelaic acid has a good barrier effect. Contact between menthol and outside air and temperature is isolated, and volatilization loss of menthol is greatly reduced.

The invention relates to the technical field of synthesis of plasticizers for polyvinyl chloride resin, and discloses azelaic acid di (2-propyl heptyl) ester and a preparation method and application thereof, and the preparation method comprises the following preparation steps: putting azelaic acid, 2-propyl heptanol, a 2-propyl heptanol derivative and deionized water into a reaction kettle, and uniformly mixing to obtain a mixture a; raising the temperature of the mixture a, keeping the temperature, continuously raising the temperature, adding a catalyst, raising the temperature again, carrying out esterification reaction, terminating the reaction, filtering and collecting the catalyst to obtain a mixture b; the preparation method comprises the following steps: mixing a mixture A and a mixture B, cooling the mixture B, adding caustic soda liquid into the mixture B, carrying out water washing neutralization, stirring, standing for layering, discharging water to collect a product, and carrying out vacuum evaporation dehydration on the product to obtain the di (2-propylheptyl) azelate as the plasticizer of the PVC material, so that the mechanical properties of the PVC material can be improved, and the di (2-propylheptyl) azelate is not easy to migrate and volatilize.

The invention discloses bio-based resin capable of being recycled in a closed-loop mode and a preparation method and application of the bio-based resin. According to the resin material, bio-based polybasic acid serves as a raw material and is mixed with 4-carboxyphenylboronic acid, then the mixture and ethylene glycol diglycidyl ether are subjected to an epoxy ring-opening reaction to prepare a bio-based monomer with the end group being boric acid, and the resin is prepared after the monomer is subjected to cross-linking polymerization. Wherein the bio-based polybasic acid is azelaic acid, sebacic acid, Brazil acid, acrylic abietic acid, eleostearic acid anhydride, maleated rosin and the like. The end group of the bio-based monomer is boric acid bonds, and small molecule amine is subjected to catalytic dehydration to form dynamic boric acid ester, so that the monomer is cross-linked to prepare a material with closed-loop recovery, shape memory and self-repairing performance, and the material has wide application prospects in the fields of 3D printing, flexible sensors and friction generator materials.