125 results about "Azelaic acid" patented technology

The invention belongs to the technical field of hair care products, and particularly relates to composite acid gel for scalp care and a preparation method thereof. Salicylic acid, glycolic acid, piroctone azelate olamine salt, echinacea purpurea-lactic acid bacteria yeast, an emulsifier and water are combined, wherein the echinacea purpurea-lactic acid bacteria yeast is prepared by performing enzymolysis on echinacea purpurea through bacillus subtilis protease and then performing aerobic fermentation with lactic acid bacteria. Salicylic acid, glycolic acid and azelaic acid in the composite acid gel are compounded, so that stimulation of salicylic acid is weakened, and the effect of dissolving hair follicle grease is reserved; glycolic acid and azelaic acid are added to accelerate keratin metabolism, regulate sebum secretion and create safe and healthy shielding for the scalp environment, and polysaccharide and flavonoid compounds in the echinacea purpurea-lactic acid bacteria leavening are beneficial to exerting the anti-oxidation and immune regulation effects of the echinacea purpurea-lactic acid bacteria leavening. Therefore, the composite acid gel provided by the invention is green, safe and non-irritant, the preparation method is simple and convenient, and the composite acid gel can be used for inhibiting bacteria and reducing scalp inflammation.

The present application provides a kind of cosmetic composition for acne and its preparation method, it is related to the technical field of cosmetics.The cosmetic composition comprises by mass percentage 0.01-2.0% of acacia gum, 0.01-2.0% of sphingomonad ferment product extract, 0.01-10% of exfoliating agent, 0.01-1.0% of oil control agent, 0.001-0.005% of bacteriostatic agent, 0.01-2.0% of anti-inflammatory agent and 0.01-2.0% of soothing and repairing agent; the balance is cosmetic base; wherein the exfoliating agent includes one or more of coated multi-fruit acid, coated azelaic acid and coated salicylic acid; the anti-inflammatory agent includes 100 and 1609; and the soothing and repairing agent includes 100, which solves the technical problems of difficult thickening, insufficient mildness and insufficient refreshing after absorption of acne-removing products.

The invention discloses a preparation method of azelaic acid, which is characterized in that under a solvent-free condition, a reusable supported heteropolyacid salt catalyst is adopted to catalyze oleic acid to oxidize so as to prepare the azelaic acid. The method is characterized in that the supported heteropolyacid salt catalyst is supported phosphotungstate or supported silicotungstate, and the oxidizing agent is hydrogen peroxide. Compared with the prior art, the method has the advantages that the catalyst can be efficiently separated and reused, the production cost is reduced, the reaction process is simple, and the process is clean.

This invention provides a novel topical composition containing azelaic acid. [Solution] A two-layer topical composition containing (A) azelaic acid and (B) a surfactant.

The invention relates to the field of cosmetics, in particular to a hair preparation for killing mites and relieving scalp inflammation and a preparation process. The composition for killing mites and relieving scalp inflammation is prepared from salicylic acid, azelaic acid, a citronella extract, a herba violae extract, a herba houttuyniae / radix scutellariae extract, a solvent, a solubilizer and water, and then the composition is applied to a hair preparation. The composition has excellent acarus killing and anti-inflammatory performance, and the hair composition is endowed with excellent performance.

The invention provides a cosmetic composition and a preparation method thereof. In particular, the cosmetic composition comprises: a linear saturated dicarboxylic acid having 4 to 10 carbon atoms; mandelic acid or a derivative thereof; and polyaspartic acid or a derivative thereof. The cosmetic composition according to the technical scheme of the invention contains higher content of straight-chain saturated dicarboxylic acid with 4-10 carbon atoms, and has excellent cutin removal and acne inhibition effects when azelaic acid is used as the straight-chain saturated dicarboxylic acid with 4-10 carbon atoms.

The invention discloses a method for directionally preparing high-purity azelaic acid from oleic acid based on a micro-channel reactor, which comprises the following steps: mixing oleic acid and hydrogen peroxide dissolved with a catalyst, and feeding the mixture into the micro-channel reactor for oxidative cracking reaction to obtain oxidation liquid mainly containing the azelaic acid and the oleic acid; standing and layering the oxidation liquid to obtain a water phase A and an oil phase A; hot water is introduced into the oil phase A containing the nonanoic acid and the azelaic acid for extraction and liquid separation, and a water phase B and an oil phase B are obtained; fractionating the oil phase B to obtain high-purity nonanoic acid; cooling and crystallizing the water phase B to obtain a crude azelaic acid product, and melting and evaporating the crude product to remove moisture to obtain high-purity azelaic acid. Based on the microchannel reactor, hydrogen peroxide is used as an oxidizing agent, oleic acid double bonds can be directionally oxidized through a catalyst system, oleic acid is directly oxidized and cracked into nonanoic acid and azelaic acid in a short time, the reaction efficiency can be greatly improved, the reaction time can be shortened, and the use of a solvent and a phase transfer catalyst is avoided; the method has the advantages of high selectivity, high safety and remarkable environmental protection.

To provide an azelaic acid derivative capable of inhibiting stimulation of skin by a skin external preparation applied thereto.SOLUTION: The azelaic acid derivative is represented by AO-C(=O)-R-C(=O)-OA (formula 1) or BO-C(=O)-R-C(=O)-OA (formula 2). The skin external preparation contains active agents, oil-based agents and water-based agents, where the azelaic acid derivative is contained as an oil-based agent. In the formulas 1 and 2, R is a C7 linear hydrocarbon group, A is represented by the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group, and B is hydrogen or the general formula CnH2n+1, CnH2n+1O or CnH2n+1O2 comprising a hydrocarbon group.SELECTED DRAWING: None

The invention relates to hair-blacking essence and a preparation method thereof. Screening a symbiotic bacterium metabolism extract with small molecule peptide metabolism regulation capability; by combining low-concentration azelaic acid and zinc lactate components, scalp grease oxidation and abnormal proliferation of propionibacterium are inhibited; the expression of IL-10 anti-inflammatory factors is induced, the expression of TNF-alpha and IL-6 is reduced, and the hair follicle microinflammation state is reduced; a Wnt / beta-catenin pathway activator is used for inducing the melanin stem cells to be in a static state; the FGF-2 and the EGF are combined in a micro-dose manner to promote the amplification into precursor cells; mITF regulation peptides and a small amount of trace copper ions are supplemented to induce directional differentiation into mature melanocytes; a microcapsule carrier system with a three-layer structure; the penetration efficiency is improved; antioxidative peptide rich in reduced glutathione, NAD and a promoting factor are used, so that melanocytes are protected from oxidative damage; a coenzyme Q10 type mitochondrial homeostasis regulator is introduced, so that the energy metabolism is improved, the cell aging is delayed, the targeting property is strong, and the effect is accurate.

The invention relates to the technical field of skin care, and discloses a sustained-release composition containing azelaic acid composite lipidosome and application of the sustained-release composition in acne treatment and skin repair. Comprising a composite liposome, an encapsulated active component and a dispersion medium, the composite liposome is composed of a lipid bilayer, the lipid bilayer comprises phospholipid, cholesterol and pegylated phospholipid, and the phospholipid is a mixture of hydrogenated soybean phospholipid and dipalmitoyl phosphatidylcholine; the encapsulated active component comprises a fat-soluble component and a water-soluble component; the water-soluble components comprise a hamamelis virginiana leaf water extract and a herba portulacae extract; the dispersion medium is a phosphate buffer solution; by optimizing lipid composition, introducing surface modification and constructing a multi-layer release system, the invention aims to synergistically exert multiple effects of antibiosis, anti-inflammation, cutin regulation, red fading, repair and the like, and provides an efficient, mild and integrated solution for acne and sequelae skin problems thereof.

The invention discloses composite hydrogel containing azelaic acid and a preparation method of the composite hydrogel, and belongs to the technical field of skin medicines.The azelaic acid is loaded and free azelaic acid is fixed through a layered structure of Ca / LDH powder, and then polymerization modification is conducted through dodecyl methacrylate, so that the composite hydrogel can be firmly smeared on the skin and is prevented from being scoured by sweat, and the skin care effect is good. Moreover, the Ca / LDH powder has an ion exchange characteristic between layers, so that a slow release effect on azelaic acid can be achieved; encapsulated menthol exists in the composite hydrogel containing azelaic acid, the encapsulated menthol is used for clathrating menthol through the clathration of a chitosan / cyclodextrin encapsulation carrier, and after clathration of the chitosan / cyclodextrin encapsulation carrier, a compact crystal structure of the carrier and the cavity clathration of cyclodextrin form a double barrier, so that the composite hydrogel containing azelaic acid has a good barrier effect. Contact between menthol and outside air and temperature is isolated, and volatilization loss of menthol is greatly reduced.

The invention relates to the technical field of synthesis of plasticizers for polyvinyl chloride resin, and discloses azelaic acid di (2-propyl heptyl) ester and a preparation method and application thereof, and the preparation method comprises the following preparation steps: putting azelaic acid, 2-propyl heptanol, a 2-propyl heptanol derivative and deionized water into a reaction kettle, and uniformly mixing to obtain a mixture a; raising the temperature of the mixture a, keeping the temperature, continuously raising the temperature, adding a catalyst, raising the temperature again, carrying out esterification reaction, terminating the reaction, filtering and collecting the catalyst to obtain a mixture b; the preparation method comprises the following steps: mixing a mixture A and a mixture B, cooling the mixture B, adding caustic soda liquid into the mixture B, carrying out water washing neutralization, stirring, standing for layering, discharging water to collect a product, and carrying out vacuum evaporation dehydration on the product to obtain the di (2-propylheptyl) azelate as the plasticizer of the PVC material, so that the mechanical properties of the PVC material can be improved, and the di (2-propylheptyl) azelate is not easy to migrate and volatilize.

The invention discloses bio-based resin capable of being recycled in a closed-loop mode and a preparation method and application of the bio-based resin. According to the resin material, bio-based polybasic acid serves as a raw material and is mixed with 4-carboxyphenylboronic acid, then the mixture and ethylene glycol diglycidyl ether are subjected to an epoxy ring-opening reaction to prepare a bio-based monomer with the end group being boric acid, and the resin is prepared after the monomer is subjected to cross-linking polymerization. Wherein the bio-based polybasic acid is azelaic acid, sebacic acid, Brazil acid, acrylic abietic acid, eleostearic acid anhydride, maleated rosin and the like. The end group of the bio-based monomer is boric acid bonds, and small molecule amine is subjected to catalytic dehydration to form dynamic boric acid ester, so that the monomer is cross-linked to prepare a material with closed-loop recovery, shape memory and self-repairing performance, and the material has wide application prospects in the fields of 3D printing, flexible sensors and friction generator materials.

The invention discloses a method for preparing bis-tocopherol azelate and application of the bis-tocopherol azelate, and belongs to the technical field of compound synthesis. The invention provides a method for preparing bis-tocopherol azelate. The yield and purity of the bis-tocopherol azelate are improved. The prepared bis-tocopherol azelate overcomes the limitation that azelaic acid is poor in permeability, high in irritation and the like, the overall effect of the bis-tocopherol azelate can be possibly improved through the synergistic effect, and a better solution is provided for skin care and treatment.

Biobased dielectric coolants and methods for making diverse high-quality biobased dielectric coolants using carboxylic acid and / or dicarboxylic acids produced from ozone cracking of lipids. The method can include reacting a fatty acid with one or more alcohols, diols, and / or triols to esterify the fatty acid to form esters having a kinematic viscosity @ 40° C. of less than 15 mm2 / s, according to ASTM D 445. The carboxylic acids and dicarboxylic acids can be nonanoic acid, malonic acid, propanoic acid, hexanoic acid, and / or azelaic acid, and can be derived from the oxidation of one or more lipids by ozone cracking.

The application provides a Candida viswanathii CATH2402, the preservation number of which is CCTCC NO: M 20241166, and also provides application of the aforementioned Candida viswanathii in fermentative production of azelaic acid, and a production method of azelaic acid. The Candida viswanathii CATH2402 can utilize various substrates to fermentatively produce azelaic acid, and has high tolerance to the product azelaic acid, thereby significantly improving the yield of azelaic acid by biological method, and having the potential for industrialized scale production.

It relates to a composition, the use of the composition for preparing a topical external formulation or a cosmetic, and a method for preparing the composition. The composition comprises a linear saturated dicarboxylic acid and a polyaspartic acid or derivatives thereof, wherein the content of the polyaspartic acid or derivatives thereof is greater than or equal to 0.01% based on the total weight of the composition. The solubility of the linear saturated dicarboxylic acid (e.g., azelaic acid) in aqueous solutions can be increased by using the linear saturated dicarboxylic acid (e.g., azelaic acid) in combination with the polyaspartic acid or derivatives thereof. It can thus have improved skin permeability, for example when used in a cosmetic, thereby exerting its efficacy to a greater extent.

The invention relates to a method for synthesizing azelaic acid and nonanoic acid through ozone oxidation by using a mixed solvent, and belongs to the technical field of fine chemical engineering. The method comprises the following steps: S1, carrying out conjugation treatment on cottonseed oleic acid, a metal oxide catalyst and maleic anhydride or acrylic acid, and then carrying out molecular distillation to obtain high-purity oleic acid; s2, mixing oleic acid with an acetic acid-low carbon alcohol mixed solvent, and sequentially carrying out pre-oxidation and deep oxidation in a tank reactor and a micro-channel reactor to obtain an odorous oxide; s3, adding hydrogen peroxide, and cracking under an acidic condition to obtain a lysate; and S4, crystallizing and separating azelaic acid, and carrying out molecular distillation on mother liquor to recover the azelaic acid and the solvent. Through raw material pretreatment and the synergistic effect of the mixed solvent and the combined reactor, side reactions are reduced from the source, so that the possible problems of low product purity, low reaction efficiency, high solvent consumption and the like in the traditional process are solved. The method is helpful for realizing higher yield and purity of the target product and promoting the cyclic utilization of the solvent, and the process flow is more green and economical.

The invention discloses supramolecular skin-tendering essence and a preparation method thereof, and relates to the technical field of cosmetic preparation, and the supramolecular skin-tendering essence comprises the following components in percentage by mass: 0.5%-2% of supramolecular azelaic acid, 0.5%-2% of supramolecular salicylic acid, 2%-8% of butanediol, 0.65%-2.6% of arginine, 2%-8% of a humectant, 0.33%-1% of a thickener, 2.2%-6.8% of a preservative and a proper amount of water. The thickening agent is prepared from sodium polyacryloyldimethyl taurate and a sphingomonas fermentation product extract according to the mass ratio of (0.3 to 0.85) to (0.03 to 0.15). The supramolecular skin tendering essence disclosed by the invention is excellent in stability and good in water solubility.

This invention belongs to the field of cosmetic research technology, specifically relating to a composition containing ultramicrovesicles, its preparation method, and its uses. The composition comprises the following components by weight: 0.01–30.0 parts of animal umbilical cord extract, 0.001–5 parts of a mixture of pro-xylene and azelaic acid, and 0.1–10 parts of niacinamide; the mass ratio of pro-xylene to azelaic acid in the mixture is 2–3:2–3. This invention combines umbilical cord extract ultramicrovesicles, the pro-xylene and azelaic acid mixture, and niacinamide to achieve a synergistic effect, resulting in better and more comprehensive efficacy in three dimensions: anti-wrinkle and firming, whitening and brightening, and soothing and repairing after application to the skin.

The invention relates to a compound preparation for preventing and treating tobacco mosaic disease and application thereof. Aiming at the problems that chemical control easily causes pesticide residues, biological control takes effect slowly and is unstable, the threshold of a gene editing technology is high and the like in the existing tobacco mosaic disease control technology, the invention provides a medicament compounded by azelaic acid and beta-aminobutyric acid according to a molar ratio of 1: (2-10). According to the agent, antioxidant enzyme systems such as SOD (superoxide dismutase), CAT (catalase) and POD (peroxidase) in tobacco plants are synergistically activated, and meanwhile, SAR (synthetic aperture radar) and SA / ABA double-signal channels are triggered, so that the self-defense capability of the plants is Experiments show that the SOD activity is improved by more than 40% after transplanting for 30 days after treatment by the medicament, and the CAT activity is improved by more than 125% after 60 days, so that the morbidity of the tobacco mosaic disease is obviously reduced, the disease index in 30 days is lower than 1.0, and the morbidity in 60 days is reduced by more than 10% compared with that of a control group. The method is easy and convenient to operate, environmentally friendly and free of residual risk, achieves the dual effects of early-stage rapid inhibition and long-term continuous control, and is efficient and safe in tobacco virus disease prevention and treatment.

The invention discloses a high-concentration azelaic acid acne-removing soothing emulsion, and belongs to the technical field of medicines and skin care products. The method successfully breaks through the technical bottleneck that the solubility of azelaic acid in a conventional water-oil system is extremely low (generally 1t; 1%). According to the invention, 13-19% high-mass-fraction stable loading of azelaic acid can be realized, the system is still kept in a uniform and transparent liquid state at room temperature and after high and low temperature circulation, no crystal is separated out, and the physical friction stimulation of azelaic acid solid crystal particles to the skin in the traditional formula is eliminated. Meanwhile, the bisabolol, capryloyl glycine and other components contained in the system have an instant soothing effect, chemical irritation of azelaic acid can be reduced, and skin tolerance and use comfort of the product are remarkably improved.

The application discloses a kind of eight treasures ten kinds of herbal extract compound active ingredient hair growth liquid and preparation method thereof, belong to the technical field of cosmetics.The hair growth liquid includes basic maintenance type, standard maintenance type, strengthening maintenance type three gradient formulations and scalp special derivative formulation, each formulation takes eight treasures ten kinds of composite herbal extract as core, is matched with active ingredient of promoting maintenance synergism.The active ingredient of promoting maintenance synergism includes bispyrimidine active substance, polypeptide component and adenosine, cooperates with eight treasures ten kinds of composite herbal extract, can realize hair follicle maintenance, hair tough and hair follicle nourishing function.Each formulation takes basic matrix, texture adjustment and soothing component, mild antiseptic system as auxiliary, product pH value is controlled at 5.0~6.5, and the sum of the weight percentage of each component is 100%;Three gradient formulations are mild and non-irritating, do not contain artificial essence, can be simultaneously applied to scalp, hairline, eyebrow and eyelash parts, and scalp special derivative formulation can selectively add mint component and azelaic acid, and is limited to scalp use only.The preparation method includes eight steps of raw material preparation, water phase preparation, oil phase mixing and emulsification, cooling feeding, pH value adjustment, auxiliary component addition, filtering defoaming and filling finished product in sequence.The hair growth liquid can be adapted to sensitive skin and various skin conditions, can nourish hair follicle, improve hair growth microenvironment, can improve hair thinning, fine and soft, easy to fall off, easy to break phenomenon, material body nature is stable, refreshing and not sticky, long-term storage stability is good, can be adapted to industrialization mass production and large-scale application and market promotion, and formulation gradient is clear, and strong expandability can meet multiple use requirements.

The invention discloses azelaic acid-pterostilbene ester and application thereof, and belongs to the technical field of compound synthesis. According to the invention, pterostilbene and azelaic acid are combined to form a new compound. The azelaic acid compound prepared by the invention not only is helpful for overcoming the limitations of poor permeability, higher irritation and the like of azelaic acid, but also can improve the overall efficacy of the azelaic acid compound through a synergistic effect, and provides a better solution for skin care and treatment.

The present invention relates to a composition in the form of an oil-in-water (O / W) emulsion, in particular a cosmetic composition, comprising: (i) at least 5% by weight of azelaic acid, the organic or mineral base salts thereof, the solvates thereof, or mixtures thereof. relative to the total weight of the composition, (ii) at least one apolar oil, (iii) at least one polyol of formula (I), (iv) less than 1% by weight of a polar oil relative to the total weight of the composition, or said composition is free of polar oil. The present invention also relates to a non-therapeutic cosmetic process for caring for keratin materials, in particular the skin, comprising the topical application to these keratin materials of a composition according to the invention, or to the use thereof for caring for the skin.

The present invention relates to an advanced dressing in the form of a collagen sheet containing chitosan and azelaic acid microspheres functionalized with ozonized oil loaded on mesoporous silica. In addition, the present invention relates to a process for producing the advanced dressing and use of the advanced dressing in treating skin and mucosal wounds.

This invention provides a composition with anti-inflammatory, acne-reducing, and oil-controlling effects, and its preparation method, comprising active functional components and excipients; wherein the active functional components are tea tree oil, benzoyl peroxide, azelaic acid, quaternary ammonium salt-73, niacinamide, zinc gluconate, retinaldehyde, salicylic acid, licorice extract, purslane extract, capryloyl glycine, acetylglucosamine, and asiaticoside; the excipients include skin conditioning agents, moisturizers, nonionic emulsifiers, and skin-nourishing agents. This invention, through targeted synergistic system design, covers the entire pathogenesis mechanism of acne, achieving synergistic effects of antibacterial acne reduction, oil control, keratinization unblocking, anti-inflammatory repair, and microecological balance; simultaneously, through gradient feeding, liquid crystal emulsification, and low-temperature activation locking preparation methods, the stability of active ingredients is preserved to the greatest extent, solving the industry pain points of traditional acne products where efficacy and gentleness cannot be simultaneously achieved, active ingredients are easily deactivated, and acne is prone to recurrence. It can be widely applied to the preparation of various acne-reducing and oil-controlling skin care products.

The PMIA loose nanofiltration membrane is prepared by taking meta-aramid as a polymer membrane material and azelaic acid as an organic small molecule additive and adopting an NIPS method coupled with a thermal induction effect. Azelaic acid regulates and controls thermodynamic behaviors of a membrane casting solution and a phase separation dynamic process of the membrane casting solution through hydrogen bonds, and in the thermal induction aftertreatment process, structural optimization is realized by overlapping capillary pressure and interfacial tension to drive a cavity shrinkage effect through thermal activation and entropy increase retraction effects of a macromolecular chain; the synergistic effect of the two breaks through the technical bottleneck of the traditional NIPS method for preparing the high-interception-high-flux loose nanofiltration membrane, and the large-scale preparation is successfully realized; the prepared membrane has high permeation flux and excellent dye / salt separation performance, the rejection rate of various different dyes is 98% or above, the rejection rate of sodium sulfate and sodium chloride is reduced, meanwhile, the high permeation flux is kept, and the membrane has excellent stability and pollution resistance and is suitable for industrial production. The method has a huge application prospect in dye wastewater treatment of textile printing and dyeing, dye production and the like.

This invention discloses an oleic acid oxidative cracking catalyst, its preparation method, and its application, belonging to the field of catalyst preparation technology. The catalyst for the oxidative cracking of oleic acid to azelaic acid is prepared by: uniformly mixing phosphotungstic acid with an organic onium salt, and then ball milling the mixture in a ball mill jar. The preparation method is simple, generates no waste, and produces a catalyst with high yield and high activity. In the process of oleic acid cracking to azelaic acid, the conversion rate of oleic acid reaches 100%, and the selectivity of azelaic acid reaches 96%.

The application provides an application of azelaic acid in promoting seed germination and / or plant growth, and belongs to the technical field of plant growth regulation. The application not only provides the application of azelaic acid in promoting seed germination and / or plant growth, but also provides a method for promoting seed germination and / or plant growth. The seed is treated with an azelaic acid solution with a concentration of 0.1-1.0 mM before sowing. The results of examples show that the azelaic acid can effectively improve the germination rate of the seed under salt stress and normal conditions, shorten the seed germination time, promote the hypocotyl growth and root growth of seedlings, and relieve the adverse effects of salt stress environment on seed germination and plant growth.