40 results about "Thioctic Acid" patented technology

The invention discloses a waterproof polyurethane material, a preparation method and application of the waterproof polyurethane material in a flexible cable, and relates to the technical field of polymer cable materials. The polyurethane material comprises the following raw material components: polyurethane, a thermoplastic polyester elastomer, a compatilizer, an inorganic filler, a dynamic cross-linking agent and an organic tin catalyst, the dynamic cross-linking agent comprises lipoic acid and / or cystamine; the inorganic filler is composed of mica powder and zirconium oxide according to the mass ratio of (2-6): 1. According to the polyurethane material disclosed by the invention, a specific amount of the specific dynamic crosslinking agent is added, so that local failure caused by stress concentration can be avoided, the fatigue resistance and the water vapor permeation resistance are enhanced, and the environmental adaptability and durability of a seabed are improved.

The application discloses a carbonyl reductase mutant and application thereof in preparation of (R)-8-chloro-6-hydroxyoctanoate compounds. The application relates to a mutant of carbonyl reductase with improved catalytic performance and stereoselectivity after rational molecular modification, a recombinant expression plasmid containing the mutant gene of the enzyme, a recombinant expression transformant, a preparation method of the recombinant enzyme, and application of the recombinant enzyme or the recombinant cell as a catalyst in asymmetric reduction of 8-chloro-6-carbonyloctanoate compounds (I) to prepare (R)-8-chloro-6-hydroxyoctanoate compounds (II), in particular, in an intermediate (R)-8-chloro-6-hydroxyoctanoate methyl ester of thioctic acid. The disclosed carbonyl reductase SsCR mutant has the advantages of high reaction efficiency and high catalytic activity, and exhibits the advantages of high substrate concentration, low catalyst consumption and short reaction time in the process of catalytic preparation of the compound (II).

The invention relates to the technical field of biological materials, and discloses a preparation method of novel antibacterial nano composite hydrogel for repairing diabetic oral ulcer. Comprising the following steps: grafting 2-formylphenylboronic acid on titanium carbide (MXene) nanosheets to form MXene (at) FPBA nanoparticles, carrying out an amidation reaction on lipoic acid and recombinant collagen to obtain modified recombinant collagen, doping the MXene (at) FPBA into the modified recombinant collagen system, and carrying out photo-crosslinking to obtain the novel antibacterial nano composite hydrogel. The hydrogel combines the strong anti-oxidation and anti-inflammatory capabilities of lipoic acid, does not need to add anti-inflammatory drugs, and also has good adhesiveness; the MXene (at) FPBA nano particles can be used for capturing bacteria and carrying out efficient sterilization; and the raw materials used by the material have biological safety. Therefore, the hydrogel has the antibacterial property and the anti-inflammatory function, and can comprehensively and efficiently manage and treat diabetic oral ulcer wounds.

The invention discloses a nano-particle for inducing death of tumor immunogen cells, a preparation method and application. The preparation method of the nano-particles comprises the following steps: taking a BiOCl nanosheet as a carrier, enabling CeO2 to generate and crystallize in situ on the surface of the BiOCl nanosheet, and forming a BiOC / CeO2 heterojunction; the method comprises the following steps: carrying out a dehydration reaction on NH2-PEG2000-NH2 and DL lipoic acid to synthesize NH2-PEG2000-TA; the preparation method comprises the following steps: reacting NH2-PEG (Polyethylene Glycol) 2000-TA with a Pardaxin peptide of which the carboxyl is activated, so as to generate Pardaxin-PEG 2000-TA; the preparation method comprises the following steps of: coupling Pardaxin-PEG2000-TA (Polyethylene Glycol 2000-TA) and a BiOC / CeO2 heterojunction; the PBCP nanoparticles obtained by the preparation method promote the yield of active oxygen in the endoplasmic reticulum of tumor cells to be increased sharply, so that the endoplasmic reticulum stress is effectively excited, tumor immunogenic cells are induced to die, and the anti-tumor effect is achieved. The nanoparticle can be combined with the existing PD-1 / PD-L1 inhibitor for use, and shows a better anti-tumor effect than the single use of the PD-1 / PD-L1 inhibitor.

The application provides an anti-carbon dioxide corrosion inhibitor, a preparation method and application thereof, and relates to the technical field of oil and gas field corrosion protection. The application provides an inhibitor, raw materials of which include alpha-lipoic acid, diethylene triamine, formaldehyde, 2-naphthyl ethyl ketone and benzyl chloride in a molar ratio of 1.0-1.2:0.8-1.2:1.2-2.0:1.0-1.4:1.0-1.4. The application also provides a preparation method, raw materials are taken according to the molar ratio, alpha-lipoic acid and diethylene triamine are mixed to obtain a first product through reaction; formaldehyde and 2-naphthyl ethyl ketone are mixed with the first product to obtain a second product through reaction; benzyl chloride and the second product are mixed to obtain a finished product inhibitor through reaction. The application also provides application of the inhibitor in preventing carbon dioxide corrosion. The inhibitor has good corrosion inhibition effect, a simple preparation method, a stable structure, and still has superior corrosion inhibition effect in a high salinity environment.

This invention belongs to the field of thermal insulation materials technology and discloses a composite thermal insulation coating based on an ethanol evaporation-induced stable covalent crosslinked adhesive phase and its preparation method. The composite thermal insulation coating includes a crosslinked adhesive phase and hollow glass microspheres dispersed and fixed within the crosslinked adhesive phase. The crosslinked adhesive phase is obtained by ethanol evaporation-induced crosslinking of a reactive precursor formed by the reaction of thioctic acid and amino-functionalized polydimethylsiloxane. During the drying process of the precursor, ethanol evaporation gradually forms an adhesive network containing polydimethylsiloxane segments and a covalently crosslinked structure derived from thioctic acid. The preparation method includes reactive precursor preparation, slurry compounding, and drying and curing steps, requiring no additional crosslinking agent or high-temperature curing, and can complete crosslinking and film formation at room temperature or under moderate heating conditions. The thermal conductivity of the composite thermal insulation coating can be as low as 0.025–0.030 W / (m·K), and it possesses good adhesion, waterproof and moisture-proof properties, mechanical stability, and environmental durability.

This application discloses a thermosensitive adhesive, its preparation method, and its application, belonging to the technical field of thermosensitive adhesives. The thermosensitive adhesive of this application is prepared by photoinitiated polymerization of a raw material mixture at a temperature of 25-120°C. The raw material mixture comprises 25-49 moles of thioctic acid, 1-25 moles of N-alkane-1,0-dimethyl thioctinamide, and 0.5-2 moles of tris(2-carbonylethyl)phosphohydrochloride, citric acid, or guanidine hydrochloride. The thermosensitive adhesive of this application exhibits adjustable adhesion properties and maintains good optical transparency and interfacial compatibility near human body temperatures of 25-40°C. It also maintains good adhesion stability in the human body fluid environment and under repeated loading or temperature cycling conditions, potentially expanding its application potential in the field of precision medicine.

The invention discloses a flexible bamboo lignin-based polymer material as well as a preparation method and application thereof. Arginine modified polyphenol bamboo lignin and lipoic acid are used as raw materials, and the flexible bamboo lignin-based polymer material with excellent performance is prepared through lipoic acid ring opening polymerization and sulfydryl free radical-polyphenol Michael addition reaction. The preparation method specifically comprises the following steps: carrying out demethylation phenolation modification on bamboo lignin by using a one-pot method, grafting arginine, improving the reaction activity of the bamboo lignin, quantitatively introducing lipoic acid, blocking by using allylurea, and synthesizing the bamboo lignin-based polymer material containing the allylurea, wherein the polymer material contains a dynamic disulfide reversible ring-opening structure. The method breaks through the limitation that the existing lignin is low in reaction activity and lignin-based macromolecules are difficult to recycle, expands the application scene and range of the lignin, and realizes a green mode of oriented preparation, cyclic processing and efficient utilization of the lignin-based macromolecules; and a theoretical basis and guiding significance are provided for high-quality development and high-valued frontier application of the forest resource lignin.

The invention discloses a high-impact-resistance elastomer composite material based on an organic-inorganic copolymerization strategy and a preparation method thereof. The composite material is prepared through an organic-inorganic copolymerization strategy and comprises metal oxide nanoparticles with the particle size of 1-10 nm and rich in unsaturated metal sites on the surface as an inorganic phase and a polymer network containing dynamic covalent bonds as an organic phase, the inorganic phase and the organic phase are connected through a chemical bond to form a molecular-scale organic-inorganic hybrid structure unit, so that uniform dispersion and strong interface combination of the inorganic phase are realized. The preparation method comprises the following steps: regulating and synthesizing zinc oxide nanoparticles with rich unsaturated sites on the surfaces through a regulator; carrying out pre-coordination assembly on the zinc oxide and a lipoic acid monomer to form a lipoic acid-zinc oxide hybrid monomer; and carrying out thermal polymerization to obtain the elastomer composite material. The elongation at break of the obtained material reaches 541% and is increased by nearly 12 times compared with that of pure polylipoic acid, the impact force can be attenuated by 90% or above in a drop hammer impact test, the impact strain rate reaching up to 4000 s <-1 > can be borne, and damage self-healing can be achieved at the room temperature without external force. The material has excellent impact resistance, high toughness, intrinsic self-healing ability and solvent-resistant stability, the preparation method is simple and controllable, and the material has wide application prospects in the fields of personal protection, aerospace, flexible electronics and the like.

The invention discloses an efficient, safe and environment-friendly method for continuous flow synthesis of 6, 8-cyclotrithioctic acid. According to the method, lipoic acid and sulfur are used as raw materials, carbon disulfide is used as a solvent, and the two solutions are continuously fed into a microchannel or a tubular reactor in proportion through a precise feeding pump and are subjected to cyclization reaction at the low temperature of 30-45 DEG C; and after the reaction is finished, distilling effluent to recover the solvent, and purifying and crystallizing the obtained product in a manner of redissolving the obtained product in a benign solvent (such as ethanol and methanol) and separating out a poor solvent (such as petroleum ether and water). According to the invention, accurate control of reaction temperature, time and material proportion is realized by utilizing a continuous flow technology, and the problems of hydrogen sulfide gas generation, high temperature and high pressure, multi-step complex purification and the like in a traditional intermittent kettle type process are thoroughly avoided. The method has the advantages of simplicity and convenience in operation, high safety, high purity (up to 99.5%), recoverable solvent, less three wastes and the like.

The application provides a two-dimensional bimetallic organic framework nanoscale enzyme hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biomaterials. The FeCuMOF bimetallic organic framework is used as a nanoscale enzyme, tannic acid and thioctic acid are used to construct a composite hydrogel system with antibacterial and antioxidant capacity, and the composite hydrogel is combined with the FeCuMOF to form a two-dimensional bimetallic organic framework nanoscale enzyme hydrogel. The two-dimensional bimetallic organic framework nanoscale enzyme hydrogel has antibacterial and antibiofilm properties, can remove various ROS by imitating the superoxide dismutase and the ability of removing ABTS free radicals, and can reduce pro-inflammatory cytokines and increase anti-inflammatory cytokines, thereby reducing periodontitis inflammation and accelerating tissue regeneration. The two-dimensional bimetallic organic framework nanoscale enzyme hydrogel serves as a multifunctional nanoscale enzyme hydrogel sustained-release platform, and provides an ideal strategy for treating periodontitis.

This invention provides a bioactive liquid adhesive mimicking cell mucus, its preparation method, and its applications. First, sodium thiooctanoate is dissolved in water and self-assembled into nanomicelles using its amphiphilic and concentration-dependent ring-opening polymerization ability, which then polymerizes to form sodium polythiooctanoate. Next, thioctic acid powder is added to the system. A stable thioctic acid-based liquid adhesive is prepared by relying on the solubilization of thioctic acid by the sodium thiooctanoate nanomicelles and the hydrogen bonding interaction between the two monomer chains. The bioactive liquid adhesive mimicking cell mucus prepared using this method is simple to prepare and simultaneously possesses good tissue adhesion ability, excellent reactive oxygen species scavenging ability, and physical barrier function. It can be applied to treat intestinal inflammatory diseases caused by flora imbalance or oxidative stress.

This application belongs to the technical field of anti-swelling agents, specifically providing a bio-based anti-swelling agent for oilfields and its preparation method. The bio-based anti-swelling agent for oilfields, by weight, includes an organic phase, an inorganic phase, and additives; the additives include potassium dihydrogen phosphate and polyethylene glycol; the organic phase includes a cationic quaternary ammonium salt and carrageenan biomaterial; the inorganic phase includes potassium chloride and ammonium chloride; the cationic quaternary ammonium salt is prepared by a nucleophilic substitution reaction of 3-chloro-2-hydroxypropyltrimethylammonium chloride and p-phenylenediamine; the preparation method of the carrageenan biomaterial includes the following steps: 1) dissolving κ-carrageenan in distilled water, adding hydrogen peroxide, adjusting the pH of the system to alkaline, and maintaining the temperature to obtain a carrageenan-based solution; 2) adding thioctic acid and sodium bicarbonate to the carrageenan-based solution, heating and stirring to encapsulate, precipitating with ethanol, filtering and drying to obtain the final product. The anti-swelling agent prepared by this application has the advantages of good durability, high anti-swelling rate, and good water resistance.

The invention discloses a degradable bio-based copolymer pressure-sensitive adhesive with high bonding strength and a preparation method thereof, and belongs to the field of high-performance polymers. According to the method, the copolymer pressure-sensitive adhesive is synthesized through emulsion polymerization, homogeneous polymerization, free radical polymerization and the like, controllable copolymerization of a lactic acid-based monomer and lipoic acid is achieved, meanwhile, the problem that a traditional polymer adhesive is difficult to degrade is solved, a reaction system conforms to the green chemical principle, and the obtained pressure-sensitive adhesive has good biocompatibility and is suitable for large-scale production. The potential influence of residues on the material performance and the environment is avoided. According to the method, a copolymer pressure-sensitive adhesive sample is prepared by adopting two sample preparation modes of hot coating and hot-pressing slicing, an aluminum sheet is taken as a test base material, a lap joint shear test is performed by utilizing a universal material testing machine, and the adhesion strength of the adhesive is obtained by analyzing force and displacement data. Experimental results show that the bio-based copolymer pressure-sensitive adhesive shows good adhesive performance in different sample preparation modes, is excellent in processing compatibility and has diversified application prospects and potential.

The invention relates to the technical field of chemical pharmacy, and discloses a method for preparing high-purity R-lipoic acid, which comprises the following steps: S1, adding (S)-6, 8-dichloro ethyl caprylate, sulfur, water and a combined catalyst into a reaction flask; s2, dropwise adding a sodium sulfide aqueous solution for a certain time and at a certain temperature; s3, after dropwise adding is completed, heat preservation is conducted till the reaction is completed, cooling is conducted, acid water is dropwise added, the system pH is adjusted, stirring and filtering are conducted continuously, water is added into a filter cake, and heating and stirring are conducted; and S4, cooling, carrying out suction filtration, and drying to obtain the product. By adding the combined catalyst, impurities such as trisulfide and S-lipoic acid can be reduced at the same time, dozens of times of water is not needed for refining, the yield of the whole process is increased to 95% from 85%, and the optical purity of the product is increased to 99.8% from 99.5%.

The invention discloses a high-refractive-index reusable optical adhesive and a preparation method thereof, and belongs to the technical field of optical adhesive preparation. The preparation method comprises the following steps: firstly, preparing a high-refractive-index carbonized polymer point by adopting a solvothermal method, then uniformly mixing the high-refractive-index carbonized polymer point as a raw material with lipoic acid and a derivative thereof, and carrying out polymerization reaction to prepare the high-refractive-index reusable optical adhesive. Compared with the prior art, the adhesive prepared by the invention is simple and convenient in preparation process, and has high refractive index, high visible light transmittance, stable interface adhesion strength and broad-spectrum substrate applicability. In addition, the adhesive has excellent reusability and recoverability, and the adhesive property and the optical property of the adhesive can still be kept stable after the adhesive is recycled for multiple times. The adhesive prepared by the invention is suitable for bonding of high-refractive-index precise optical elements, Fresnel reflection caused by refractive index mismatch can be effectively reduced, and recycling and reutilization of the elements can be realized.

This invention discloses an epoxy ester resin for corrosion-resistant, high-adhesion anti-corrosion coatings and its preparation method. The epoxy ester resin is constructed by esterifying epoxy resin with fatty acids, followed by stepwise grafting of conjugated Schiff bases and thioctic acid disulfide bonds to build a dual dynamic network. This invention achieves highly efficient self-healing of the coating at room temperature through the chemical bonding and synergy of the conjugated Schiff base and disulfide bonds; and by utilizing the hydrophobic benzene ring structure and semi-interpenetrating double network design of the conjugated Schiff base, it endows the coating with high density and excellent corrosion resistance. This invention achieves a synergistic unity of room temperature self-healing and long-term corrosion protection in an air-drying epoxy ester system.

The invention belongs to the technical field of biological catalysis, and particularly relates to a carbonyl reductase mutant and application of the carbonyl reductase mutant in synthesis of an R-lipoic acid chiral intermediate (R)-6-hydroxy-8-chloro ethyl caprylate. According to the method, an unseparated and purified 6-oxy-8-chloro ethyl caprylate stock solution is used as a substrate, carbonyl reductase mutant coupled glucose dehydrogenase BtGDH is used as a catalyst, and the (R)-6-hydroxy-8-chloro ethyl caprylate is asymmetrically synthesized under mild conditions (20-40 DEG C, pH is 6-9). The (R)-6-hydroxy-8-chloro ethyl caprylate enzyme can be used for completely converting 500 g / L of 6-oxy-8-chloro ethyl caprylate stock solution within 8 hours to synthesize optically pure (R)-6-hydroxy-8-chloro ethyl caprylate. According to the method, the substrate does not need to be pretreated (solvent removal), the synthesis yield can reach 87%, and the method has the advantages of being high in space time yield, simple in process, green, environmentally friendly and the like.

The application belongs to the technical field of lithium batteries, and discloses a double-network structure binder for a silicon-based negative electrode of a lithium ion battery and a preparation method and application thereof. The double-network structure binder is abbreviated as SGLT, wherein silk glue protein is dissolved in water, glutaraldehyde and an HCl solution are added to prepare an SG solution, then tannic acid and thioctic acid are added, in-situ polymerization is carried out at 120-180 DEG C, and the network LT is prepared based on the network SG formed by the tannic acid and the thioctic acid. The application first crosslinks to form a hard network SG, and then forms a network LT based on the network SG. The hard network SG serves as a stable skeleton and effectively inhibits the volume expansion of the electrode structure. The high-elasticity soft LT network serves as a buffer layer and relieves the stress generated by the volume expansion in the electrode. The binder has excellent mechanical properties, effectively inhibits the volume expansion of the SiO x negative electrode during the charge-discharge cycle process, and ensures the cycle stability of the electrode.

The present application relates to a kind of degradable disulfide bond-containing peroxide ester initiator and its preparation degradable branched polymer application, belong to the field of functional initiator design.The present application uses tert-butyl (cumene) peroxide and thioctic acid as raw material, synthesizes the peroxide tert-butyl (cumene) thioctic acid ester containing ring-opening polymerizable disulfide bond as initiator, initiates vinyl monomer to carry out self-initiated radical polymerization reaction, and successfully obtains degradable branched polymer.Through adjusting the amount-of-substance ratio of initiator and polymer monomer, the branching degree of polymer is adjusted, the degradable disulfide bond-containing peroxide ester functional initiator is synthesized in the present application, under the initiator, under conventional radical polymerization conditions, without branched monomer, and successfully prepared degradable branched polymer.The reaction method is simple and easy to operate, and monomer conversion rate is high, the branching degree of polymer is controllable, and the branched polymer can be degraded, and the applicability of branched polymer for various types of monomers is strong.

The application relates to the technical field of silicone oil, and particularly discloses a self-healing type modified hydrogen-containing silicone oil and a preparation method thereof. The preparation method of the self-healing type modified hydrogen-containing silicone oil comprises the following steps: mixing polymethylhydrosilane and allyl glycidyl ether, heating to 90-120 DEG C, adding a platinum catalyst, stirring for 2-4 hours to obtain an intermediate reactant; uniformly mixing thioctic acid and ZnAA at 130-140 DEG C in a molten state, adding the intermediate reactant, and quickly stirring until homogeneous to obtain the self-healing type modified hydrogen-containing silicone oil. The self-healing type modified hydrogen-containing silicone oil introduces an epoxy group into a silicone oil molecular chain, and further connects thioctic acid through the epoxy group, thereby creating a self-healing and remodelable organic silicon material, and the self-healing type modified hydrogen-containing silicone oil has excellent mechanical properties.

Disclosed herein are the compounds shown below. R1 isR2 is an organic group, R3 is —H, —[(CH2)2—O]m—(CH2)2—OH or —(CH2)2—CO—O—R4, at most one of the R3 groups is —H, and R4 is an alkyl group or H. The sulfur atoms of these compounds may be bound to nanoparticles, such as semiconducting material, gold, silver, copper, platinum, or palladium.

This invention discloses a thioctic acid lignin-based DLP photocurable resin with both high stability and recyclability, and its preparation method. The resin comprises, by weight percentage: 16-80% thioctic acid polylactic acid oligomer, 0.5-7% thioctic acid lignin, 10-70% thioctic acid monofunctional diluent, and 0.5-7% photoinitiator, with the sum of the weight percentages of all components being 100%. This invention introduces thioctic acid lignin, utilizing its natural UV absorption capacity and rigid framework reinforcement, solving the problem of poor storage stability (less than one week) of traditional thioctic acid-based resins. It can be stored in a light-protected, sealed container for more than two years. The resin viscosity can be flexibly adjusted within the range of 10-2000 mPa·s to adapt to different DLP printing scenarios. After curing with 365-405 nm UV light, the tensile stress of the product reaches 30 MPa, and the fracture strain reaches 50%. The molding resin can be completely depolymerized and recycled in N,N-dimethylformamide at 150 °C without a catalyst. This invention achieves multiple objectives, including high stability, high precision, and recyclability, and can be widely applied in additive manufacturing fields such as rapid prototyping, precision parts, cultural and creative products, and medical devices.

The invention belongs to the field of biomedical materials, and particularly relates to a body temperature response type double-sided patch and a preparation method and application thereof, and the body temperature response type double-sided patch is composed of a shape memory polymer and a zinc ion slow-release bonding layer; the shape memory polymer is prepared by crosslinking diisopropenyl benzene, lipoic acid, cellulose acetate and iron ions. The zinc ion slow-release adhesive layer is obtained by dissolving zinc ions in a lipoic acid solution, wound repair can be adaptively promoted at the body temperature, and compared with the prior art, the healing time is shortened, complications are reduced, the wound healing quality is improved, and regenerative repair is achieved.

The application discloses a pharmaceutical salt of lamotrigine, a pharmaceutical composition, a preparation method and application. Through a drug-drug combination strategy, lamotrigine and thioctic acid are combined in the form of a salt or a mixture. In the treatment of epilepsy, the lamotrigine fragment can inhibit abnormal discharge and excessive excitement of the brain, and the thioctic acid fragment can enhance the resistance of the brain to seizures, reduce the damage to the brain after seizures, and play a synergistic multi-pathway treatment effect to delay the development of the disease. Meanwhile, the formed salt has better physical and chemical stability, dissolution, pharmacokinetics and pharmacodynamics, and is more beneficial to the preparation of a medicine, and an effective epilepsy treatment drug is provided.

The application discloses an illumination self-enhancing photocatalytic material and a preparation method and application thereof, and belongs to the technical field of photocatalytic materials. The material is obtained through cross-linking reaction of a composite photocatalyst, thioctic acid, polyethylene glycol and polyacrylamide, wherein the composite photocatalyst comprises the following raw materials in parts by mass: 1.2-2.4 parts of ammonium molybdate tetrahydrate, 0-5 parts of thiocarbamide and 0.006-0.018 parts of fullerene. The application can realize efficient removal of tetracycline by introducing the composite photocatalyst with high specific surface area and combining with the hydrophilic hydrogel matrix. Meanwhile, the material can enhance the hydrogel strength under illumination, and further improve the mechanical strength and durability of the material.

The application discloses a biomedical adhesive as well as a preparation method and application thereof, and belongs to the technical field of bio-based polymer adhesives and preparation thereof. The application solves the problems of limited use shape and harsh storage conditions of the existing biomedical adhesives. In the polymerization process of thioctic acid and an adhesion enhancer, an NHS ester structure is separated in the form of a monomer in the system or is introduced into a polymer chain segment by polymerization, so that a thioctic acid-NHS ester biomedical adhesive with strong stability, good biocompatibility, no tissue toxicity, implantability in the body or adhesion to a body surface wound, isolation of the wound, adhesion and fixation of tissues, and the functions of helping wound healing and repair is prepared. The adhesion performance of the biomedical adhesive does not decrease with the change of time, has good room temperature storage stability, can realize long-time effective adhesion to tissues, and has high adhesion performance to various tissues and various polymer materials.

The application relates to the technical field of high polymer materials, and discloses a bottle-brush structure-based shape memory polymer and a preparation method thereof, which comprises the following steps: dissolving a polycaprolactone precursor modified by thioctic acid at two ends in a good solvent to prepare a polymer solution, and irradiating the polymer solution with ultraviolet light in a mold to induce the photo-dimerization reaction of thiolane groups at the chain ends of the polymer to crosslink and polymerize the polymer into a product, and complete the structure construction of a covalent self-adapting network rich in dynamic disulfide bonds. The bottle-brush crosslinking network is constructed by adopting a photo-induced disulfide bond crosslinking mechanism, the material can be solidified and formed at room temperature, and the thermal degradation of the polymer main chain caused by high temperature is avoided; meanwhile, the dynamic exchange mechanism of the disulfide bond is utilized, the polymer network can be degraded and regenerated, and the problems that a conventional shape memory polymer cannot be reshaped after being formed and cannot be recycled by chemical closed loop are solved.

A method for preparing a poly(thioctic acid)-copper coating (poly(TA-Cu)) on a surface of a cardiovascular stent material includes: grinding a cardiovascular stent material with sandpaper until the surface of the cardiovascular stent material is flat and smooth, rinsing the cardiovascular stent material with deionized water and anhydrous ethanol in sequence, and drying the cardiovascular stent material to obtain a pre-treated cardiovascular stent material; dissolving thioctic acid in an alcoholic solvent, adding anhydrous copper chloride to a mixed solution of thioctic acid and the alcoholic solvent, stirring the mixed solution, to yield a precursor solution; treating the pre-treated cardiovascular stent material with the precursor solution, and drying, thus forming a poly(thioctic acid)-copper coating on the surface of the pre-treated cardiovascular stent material. The concentration of thioctic acid in the alcoholic solvent is 0.1-0.3 g / mL, and the molar ratio of anhydrous copper chloride to thioctic acid monomer is 1:100-5000.

The invention discloses a zwitter-ion-based dipole assembly quenching-pH response activated quantum dot fluorescent probe as well as a preparation method and application thereof, and relates to the field of biological imaging. The preparation method comprises the following steps: reacting sulfamide betaine with lipoic acid ester to obtain a zwitter-ion LAE-AB containing a disulfide bond; then zwitter-ions LAE-AB and quantum dots are subjected to a complex reaction through disulfide bonds to obtain modified quantum dots, finally, the modified quantum dots are self-assembled to form an assembly, and the quantum dot fluorescent probe is obtained. The fluorescent probe keeps a dipole assembly state in blood, fluorescence at the moment is remarkably weakened or even completely disappears due to an aggregation fluorescence quenching effect, after the fluorescence reaches a tumor site, protonation of the nano-carrier is triggered through weak acid response to achieve a dispersed state, the size is greatly reduced while the fluorescence is recovered, and the fluorescence intensity is reduced. In addition, due to charge transformation from negative potential to positive potential in protonation, penetration of the nano-carrier into tumor cells is promoted, and the fluorescence imaging effect is further enhanced.