92 results about "Thioctic Acid" patented technology

Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-alpha-lipoic acid are administered. Optionally, coenzyme Q and / or creatine also are administered. Preferably 10 mg to 500 mg / day of coenzyme Q10 and 1 to 30 grams / day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

The invention discloses a thiol-polyethylene glycol modified magneto-optical composite nano-material and its application. An up-conversion nano material is taken as a basal layer, the surface of the basal layer is provided with a polyacrylic acid layer, the surface of the polypropylene layer is provided with a layer of dopamine modified ferriferrous oxide magnetic particles, a golden shell layer is covered on the dopamine modified ferriferrous oxide magnetic particles layer, and the thioctic acid modified polyethylene glycol is provided on the golden shell layer; the thiol-polyethylene glycolmodified magneto-optical composite nano-material has guidance functions of up-conversion imaging and magnetic resonance imaging dual imaging, under the physical induction action of the magnetic field, the nano-material of the invention enables magnetic targeting to the specific position, so that the distribution in other internal organs can be reduced, and the damage in other internal organs during the treatment process is reduced. The nano-material can be taken as a good reagent for photo-thermal treatment by using the strong absorption property on the surface. The magnetic targeting photo-thermal treatment is combined under the imaging guidance, thereby the composite nano-material of the invention plays an important effect in clinical medical science and biological technology in future.

The invention relates to a food composition for maintaining oxide concentrations in human bodies. According to the invention, natural pigments and phenolic compounds are adopted as main materials, and other vitamins, coenzyme Q10, thioctic acid, plant rennet, and plant pectin are adopted as auxiliary materials. The composition is advantaged in that: with daily diets, efficacies such as intelligent improving, physical fitness improving, disease curing, health preserving, health caring, and aging delaying can be achieved.

The invention discloses a branched gold-platinum dual-metal nanoparticle as well as a preparation method and application thereof. The gold-platinum dual-metal nanoparticle has photo-thermal / radio-sensitization combined treatment performance and structurally contains gold-platinum nanoparticles and polyethylene glycol, wherein the gold-platinum nanoparticles are used for photo-thermal / radio-sensitization combined treatment, and polyethylene glycol is used for the surface modification of a thioctic acid terminal of a hydrophilic polymer. The gold-platinum dual-metal nanoparticle can be applied to the photo-thermal / radio-sensitization combined treatment and has the advantages of simplicity in preparation, low cost and remarkable treatment effect.

The invention is a health product for diabetes, relating to the field of health products, prepared of Oyster Shell extract, Se-enriched yeast, Cr-enriched yeast, L-zinc aspartate, L- magnesium aspartate, linolenic acid powder, alpha- Thioctic Acid, Bitter Melon P.E, P. tataricum Linn extract, Fructus lycii P.E, Dwarf Lilyturf Tuber extract, Cortex Mori extract, Fructus Corni extract, and Fenugreek P.E, and it can promote insulin function to be normal, synthetically supplement nutrition deficient in the diets of patients suffering from diabetes, prevent complication of diabetes, protect brain, eyes, and heart, promote cooperation of immune system, nerve system and endocrine system and synthetically regulate blood sugar to be stable.

The invention discloses a thioctic acid-modified hydrophilic polymer for a side chain, a preparation method thereof and application thereof. The thioctic acid-modified hydrophilic polymer is an amphiphilic polymer, wherein the main chain of the amphiphilic polymer is the hydrophilic polymer; the side chain is a thioctic acyl; and the thioctic acyl is condensed with a hydroxyl or an amido in the hydrophilic polymer to form an ester bond or an amido bond. Nano particles formed by self-assembly of the amphiphilic polymer can be cross-linked to obtain stable cross-linked polymer nano particles which are sensitive to reduction, so the nano particles are not easy to disaggregate outside cells or in blood and then a medicament wrapped by the nano particles is ensured to be stable; once entering a tumor cell, the nano particles are quickly de-cross-linked to be disaggregated, so the medicament are quickly released and a high-efficiency treatment effect is achieved; and the disadvantages of easiness in leakage of the medicament in vivo, low carrying efficiency, slow release in cells and the like are overcome.

The invention relates to a bismercapto compound modified water-soluble quantum dot and its preparation method. The bismercapto compound modified water-soluble quantum point is prepared through connecting a bismercapto compound treating polyethylene glycol or its derivative as a basic skeleton with thioctic acid and reacting the bismercapto compound with a monomercapto group coated water-soluble quantum dot under the protection of nitrogen. The preparation method concretely comprises the following steps: carrying out an esterification reaction of the bismercapto compound treating polyethylene glycol or its derivative as a basic skeleton and thioctic acid, and carrying out ring opening to obtain a bismercapto ligand; and fully reacting the obtained ligand with the water-soluble quantum dot to obtain the stable bismercapto ligand modified water-soluble quantum dot. The bismercapto compound modified water-soluble quantum dot prepared through the method can be widely applied in the biological field, the medicinal field, the diagnosis field and the like.

The invention discloses a preparation method and use of a thioctic acid-modified polyethylene glycol-polyaminoacid amphiphilic triblock copolymer. A hydrophilic chain of the amphipathic triblock polymer is polyethylene glycol, a middle hydrophobic chain segment of the amphipathic triblock polymer is poly(benzyl glutamate), a tail hydrophobic chain segment of the amphipathic triblock polymer is polyphenylalanine and the side chain of the middle chain segment is modified through thioctic acid. The amphipathic triblock polymer is self-assembled in water to form a polymer nanometer micelle with polyethylene glycol as an outer crown, thioctic acid-modified poly(benzyl glutamate) as a middle shell and polyphenylalanine as an inner core. Through crosslinking of the nanometer micelle, the stable reduction-sensitive shell crosslinked nanometer micelle is obtained so that the nanometer micelle is not easily dissociated in vitro and in blood and thus stability of a nanometer micelle-coated drug is guaranteed. When the nanometer micelle enters a tumor cell, the nanometer micelle can be fast crosslinked and dissociated so that the drug can be fast released and produces high treatment effects. The amphipathic triblock polymer solves the problems of drug leakage in vivo, low conveying efficiency and slow release in cells.

The invention relates to a composite antioxidant for improving reproductive capacity of a male animal, which belongs to the technical field of animal feed and comprises the following components by weight percent: 6.5-8.5% of food grade vitamin E, 11.0-15.5% of food grade vitamin C, 20.0-40.0% of food grade tea polyphenols, 4.0-6.0% of food grade thioctic acid and the balance of food grade corncobpowder which is taken as a carrier. The composite antioxidant can significantly reduce the content of nitrogen oxide free radicals and malonaldehyde in serum, improve the activity of SOD enzyme, significantly increase the number of sperms and the number of a grade sperms (the sperms with strong activity) in a male rat and improve the reproductive capacity of the male animal.

The present invention is directed to compositions for preventing or reducing the flush and other unpleasant symptoms that sometimes accompany the consumption of alcoholic beverages, and methods for use of said compositions. The compositions comprise an agent, or combinations of various agents, such as an agent capable of increasing intracellular or intramitochondrial concentration of NAD in the subject; an agent capable of increasing glutathione concentration in the subject; an anti-oxidant; alpha-lipoic acid or a precursor to alpha-lipoic acid; and / or an agent capable of increasing the level of Coenzyme A in the subject; where the agent or agents are present or administered in amounts effective to prevent or reduce the alcohol reaction in a subject who has consumed one or more alcoholic beverages.

The invention discloses antioxidant composition. The antioxidant composition is prepared from the following raw materials: a polygonum cuspidatum extract, a turmeric extract, a green tea extract, alpha-lipoic acid and a coenzyme Q10. The invention further discloses a preparation method and application of the antioxidant composition. The antioxidant composition combines the polygonum cuspidatum extract, the turmeric extract, the green tea extract, the alpha-lipoic acid and the coenzyme Q10 for use, so that the antioxidant composition has a significant antioxidant effect, can effectively inhibit generation of oxygen free radicals, and can be used for treating and / or preventing ischemia-reperfusion injuries.

The invention discloses a Chinese hamster ovary culture medium as well as a preparation method and application thereof. The culture medium comprises ascorbic acid, pyridoxine hydrochloride, vitamin B12, nicotinamide, riboflavin, thiamine chloride, choline chloride, folic acid, calcium pantothenate, sodium pyruvate, reduced glutathione, inositol, biotin, hypoxanthine, putrescine, lipoic acid, linoleic acid, thymine, glucose, HEPES (2-hydroxyethyl) buffer solution, dextran sulphate, Pluronic-F68, various amino acids and salts thereof and various inorganic salts. The culture medium has low cost, and the component does not contain animal origin ingredients, does not contain protein and has definite chemical ingredients. All ingredients are cooperated and blended, and the Chinese hamster ovary culture medium can satisfy the basic growth requirement of cells, and can effectively regulate, transfer and control the culture of cells so as to realize good high-density cell culture. Compared with the culture effect of the existing culture medium, the culture effect of culture medium disclosed in the invention is at least equivalent to even superior to the existing culture medium.

The present invention is coated thioctic acid tablet for treating and controlling diabetic neural lesion and belongs to the field of medicine technology. The tablet core consists of thioctic acid 600 mg, stuffing / diluent 150-180 mg, adhesive 20-25 mg, disintegrant 20-25 mg and lubricant 80-90 mg, and has total weight of 889.6-938.2 mg. The coating consists of skeleton / filming agent 10-12 mg, opacifier 5-6 mg, coloring agent 0.1-0.2 mg, surfactant 0.5-1 mg and plasticizer 5-6 mg, and has total weight of 20.10-24.20 mg. The present invention has less excipient for easy orally taking, film to screen light for long preservation period and high medicine content.

A slow-release tablet of alpha-thioctic acid or its derivative used as medicine, food additive, or cosmetic has a single slow-release layer made of hydroxypropyl methylcellulose or one slow-release layer plus one ordinary-release layer for quickly releasing the alpha-thioctic acid or its derivative. Its preparing process is also disclosed.

The invention discloses an improved Neurobasal B27 culture medium. One liter of a Neurobasal culture solution comprises 0.09-0.11 g of biotin, 18-22 micrograms of corticosterone, 1-3 g of L-carnitine, 0.9-1.1 g of linoleic acid, 0.9-1.1 g of ethanol amine, 0.9-1.1 g of linolenic acid, 13-17 g of D(+)-galactose, 6-7 micrograms of progesterone, 15-17 g of putrescine dihydrochloride, 0.08-0.12 g of retinyl acetate, 2.2-2.8 g of thyroid-hormone-removing bovine serum albumin, 0.8-1.5 g of DL-alpha-tocopherol, 2-3 g of catalase, 0.9-1.2 g of DL-alpha-tocopheryl acetate, 0.8-1.3 g of reduced glutathione, 42-52 micrograms of lipoic acid, 2-3 g of superoxide dismutase, 4-6 g of transferring, 3-5 g of human insulin and 0.12-0.16 mg of sodium selenite. The invention further discloses a preparing method and application of the improved Neurobasal B27 culture medium. The improved Neurobasal B27 culture medium can be used for researching the influence of thyroid hormones on the process that embryonic stem cells are differentiated into nerve cells.

The invention relates to the field of pharmaceutical chemistry, specifically to a new crystal form of R(+)-thioctic acid-L-lysinate, namely its crystal form I and its preparation method. The invention also relates to a pharmaceutical composition containing the new crystal form and an application of the pharmaceutical composition in the preparation of drugs for treating paresthesia caused by diabetic peripheral neuropathy. By the use of Cu-K alpha radiation, the X-ray power diffraction of R(+)-thioctic acid-L-lysinate crystal form I has diffraction peaks at 5.012, 7.589, 10.072, 12.549, 15.036, 16.688, 18.627, 19.356, 25.064 and 27.611 when expressed with 2 theta degrees, wherein the error range of 2 theta value is + / - 0.2.

Disclosed is a recovering method for the mixture waste gas of the chlorine hydride and the sulfur dioxide in the thioctic acid production, which belongs to the mixture waste gas recovery technical field in the thioctic acid production. The recovering method includes that the mixture waste gas of the chlorine hydride and the sulfur dioxide is introduced to a water absorption device through the pipeline; when the concentration of the chlorine hydride solution in the water absorption reaches the discharge concentration, the chlorine hydride is recovered; the purified sulfur dioxide gas after the adsorption of the chlorine hydride gas is sucked to the reactor device by the pipeline in the vacuum way and reacts with the sodium hydroxide solution in steps while the chlorine hydride gas is absorbed by the water absorption device; the reaction temperature and the PH value are respectively controlled and adjusted in steps so that the sodium sulfite solution is obtained; the sodium sulfite solution is discharged from the reactor device and fed to a centrifugal separation device for centrifugal separation, so as to obtain the seven hydrate sodium sulfite crystal; the mother liquor obtained through the centrifugal separation is fed to the reactor device again. The recovering method for the mixture waste gas of the chlorine hydride and the sulfur dioxide has the advantages of environmental protection, resource maximum utilization and saving production cost for the thioctic acid production enterprises.

A powder composition, includes: (A) an oil-soluble antioxidant substance powder; (B) a water-soluble antioxidant substance powder; and (C) thioctic acid.

A firming and whitening mask mainly comprises hyaluronic acid, mycose, glycerin, an aloe extract liquid, allantoin, rose water, dipotassium glycyrrhizinate, deionized water, xanthan gum, a moss extract product, methylisothiazolinone, thioctic acid, azone, phenylethyl resorcinol and an alga extract product. A preparation method of the mask comprises the following steps: adding hyaluronic acid and xanthan gum into deionized water, carrying out stirring heating, and adding mycose, allantoin and dipotassium glycyrrhizinate; 2, cooling, adding glycerin, and adding the aloe extract liquid, rose water, thioctic acid, azone, phenylethyl resorcinol and the alga extract product; 3, cooling, and adding the moss extract product and methylisothiazolinone; 4, sampling, discharging, and putting a material obtained after discharging in a standing room; 5, filing a bag with a mask plaster; 6, loading a material obtained in step 4 into the mask plaster bag; and 7, sealing the mask bag, and packaging the mask bag in a box. The firming and whitening mask moistens dry skins, makes skins fine, soft and smooth, deeply diffuses into skins, combines with deep water, maintains skins moist and glossy, and has allergy preventing, skin firming and whitening effects.

A freeze-dried powder injection of thioctic acid contains proprotionally the thioctic acid, antioxidizing agent and pH regulator. Its advantages are high curative effect and high stability.

A diffusion rate limiting matrix is utilized to lingually and / or sublingually deliver thioctic acid. This limited release matrix is intended for general nutritional supplementation and / or the treatment of various physiological disorders. Due to its lingual nature, this rate limiting matrix can produce IV-equivalent plasma levels and is not meant to be swallowed.

The invention provides a composition containing thioctic acid and an extract of root of red-rooted salvia and application thereof in the fields of cosmetics and dermatology, and belongs to the field of cosmetics. The composition has reasonable components and is the freckle-removing and skin-whitening composition which can generate synergistic effect, has obvious effect, and is safe and stable.

The invention relates to a method used for preventing and treating marine organism fouling, and more specifically relates to a method used for preparing a bionic ultra-smooth surface with self repairing performance at room temperature. The method comprises following steps: thioctic acid (TA) is heated for ring-opening polymerisation reaction so as to obtain linear poly thioctic acid; 1,3-diisopropenylbenzene (DIB) and a metal chloride are added successively for crosslinking reaction so as to obtain a crosslinked polymer; n-alkanes are added into the crosslinked polymer, and cooling to room temperature is carried out so as to obtain the bionic ultra-smooth surface. According to the bionic ultra-smooth surface, substrate material self repairing is realized at room temperature through the co-effect of hydrogen bonds, metal-ligand coordination effect, and disulfide bonds in a substrate, and cold precipitated n-alkanes are capable of providing an interface with ultra-smooth capacity; the ultra-smooth surface possesses potential capacity in inhibition bacteria adhesion on the surface; and the self repairing function of the substrate is capable of prolonging service life of the bionic ultra-smooth surface in prevention of biological fouling.

Glutathione (GSH) is a tripeptide of extreme importance as a catalyst, reductan, and reactant. It can be depleted intra-cellularly either by forming a direct complex with an electrophilic agent (accomplished investigationally by agents such as bromobenzene or diethyl maleate), by way of inhibition of synthesis, or by subjecting cells to oxidant stress. Most cells, except for epithelia cells, do not have a direct transport capacity for intact GSH. Non-epithelial cells must either transport precursor substrates for GSH synthesis or salvage amino acids from circulating GSH for reuse in intracellular resynthesis. Dietary cysteine is a rate limiting substrate for the synthesis of glutathione and also inhibits GSH efflux. Although GSH is synthesized from precursors in virtually all cells, the liver is the main source of plasma GSH. Protection and support of liver function is paramount to elevating GSH levels. The disclosure is also of a unique combination of nutritional supplements including n-acetyl cysteine, vitamin C, 1-glucosamine, n-acetyl d-glucosamine, quercitin, sylimarin, Alpha lipoic acid and high protein, low fat whey that are combined to support various bodily systems involved in glutathione synthesis, reutilization and storage; all intended to elevate glutathione concentration in the mammalian cell.

A composite medicine used also as the additive of cosmetics and health-care food for lowering blood viscosity, dissolving thrombus, and regulating blood pressure, blood sugar and blood fat is prepared through extracting to obtain L-polybasic metallothionein (L.pMT), lumbrikinase and antibacterial peptide, proportionally mixing it with the extracts of astragalus root and red sage root, thiooctanoic acid and 1,6-pectose-zinc biphosphate, and dispensing.

The invention discloses a stable pharmaceutical composition. The stable pharmaceutical composition contains (6S)-5-methyl-calcium tetrahydrofolate crystal and / or pharmacologically acceptable reducingsubstances as well as pharmacologically acceptable auxiliaries, wherein the reducing substances can protect (6S)-5-methyl-tetrahydrofolic acid and a salt thereof from being oxidized, and are selectedfrom vitamin C and a salt thereof, iso-vitamin C and a salt thereof, mercaptoethanol, cysteine, mercaptoethyl sulfoacid, dithiothreitol, reduced glutathione and thioctic acid. The stable pharmaceutical composition provided by the invention has good stability during processing and storage, avoids drug use risk caused by degradation, and ensures quick and reliable release of (6S)-5-methyl-tetrahydrofolic acid in the composition.

The present invention relates to compositions and methods for prophylactic nutritional supplementation and therapeutic nutritional supplementation. Specifically, the composition provides a nutritional supplement with a beneficial increased supplementation of vitamin D and the method involves administering to an individual a composition comprising carotenoids, vitamin E, vitamin D, vitamin C, thiamine, riboflavin, niacin, folic acid, pyridoxine, biotin, pantothenic acid, cobalamin, magnesium, manganese, zinc, selenium, chromium, copper, alpha lipoic acid, and lutein.

The invention relates to the technical field of chemical synthesis, in particular to thio-octyl phosphoramido ester and a synthetic method and application thereof. The synthetic method of the thio-octyl phosphoramido ester includes the step of: adopting thioctic acid as a raw material, performing a reduction reaction to obtain thio-octanol, and performing an esterification reaction to obtain the thio-octyl phosphoramido ester. When the thio-octyl phosphoramido ester is used as a DNA end-group modifier, DNA with sulfur-containing modified end groups can be prepared efficiently and massively, and the simple and efficient DNA end-group modifier with controllable cost can be provided for sulfur-containing modification of a 5' end of DNA; meanwhile, the synthetic method has the advantages of aconcise path, convenient operation, a simple method for purifying intermediates and the product, and requirements of scientific research and business can be fully met.

The invention belongs to the technical field of biology, and relates to a medicinal composition for preventing and treating Alzheimer's disease and senility and a preparation method thereof. The medicinal composition contains sulbutiamine of different formulations and / or thioctic acid, carnitine, zinc sulfate, coenzyme Q10, vitamin B6, mecobalamin and / or folic acid. Integral animal experiments are performed by separately using the sulbutiamine of different formulations or using a combined formula with different components such as the sulbutiamine, thioctic acid, carnitine, zinc sulfate and the like, and the results prove that the medicinal composition can effectively defer the senility of wild aged mice and transgenic Alzheimer's disease mice, improve the cognitive function thereof, prolong the average expected service life and the like and has wide clinical application prospect.

The invention provides a thioctic acid dispersible tablet and a preparation method thereof. The thioctic acid dispersible tablet contains thioctic acid, a disintegrating agent, a binder and a lubricant, wherein the lubricant does not contain magnesium stearate.