81results about How to "Improve sustained release" patented technology

The invention discloses multiple emulsion of arbutin. The carrier is loaded with active components of the arbutin. The multiple emulsion is characterized by comprising the following components in percent by weight: 0.5-2% of arbutin, 0.5-2% of hydrophilic emulsifier, 8-15% of lipophilic emulsifier, 25-40% of composite lipid material and the balance of deionized water, wherein the composite lipid material is mixture of a solid lipid material and a liquid lipid material; the lipid material is at least one of the compounds: glycerin monostearate, oil-tea camellia seed oil, aloe oil, macadamia nut oil, avocado oil, acetylated monoglyceride, caprylic capric triglyceride, canola oil, sunflower seed oil and soybean oil. The multiple emulsion disclosed by the invention has good stability and water solubility; and the preparation method is simple and controllable, is good in repeatability and can be applied to preparation of cosmetics containing the arbutin.

The invention provides an aromatic antibacterial microcapsule with a carbon skeleton and a preparation method thereof. In the invention, essence oil is used as a core material, natural polymer gelatinand Arabic gum are used as wall materials, and the antibacterial carbon skeleton aromatic microcapsule is prepared through a complex coacervation method. The preparation method comprises the following steps: firstly, treating plant pollen, calcining the pollen into a hollow carbon skeleton, and supporting silver nanoparticles on the surface of the carbon skeleton through a sol supporting method;then dispersing and coating the core material essence essential oil in the hollow carbon skeleton; and finally, gradually depositing gelatin and Arabic gum on the surface of the carbon skeleton to coat the core material, and adding a cross-linking agent for curing the material to form the long-acting slow-release aromatic antibacterial microcapsule with a stable structure. The carbon skeleton microcapsule prepared by the invention has aromatic odor and antibacterial property, and has the characteristics of environmental protection, no toxicity, slow release, bacteriostasis, good mechanical strength, good heat resistance and the like. According to the preparation method, the application stability of the essence microcapsules is improved, and the service life is prolonged.

The invention discloses a sustained release biological medicinal fertilizer, and belongs to the field of fertilizers. The sustained release biological medicinal fertilizer is prepared by taking 5-10 parts of borax, 6-13 parts of triadimenol and 7-15 parts of organosilicone polyoxyethylene ether compound, mixing, pulverizing, screening by a 100-mesh sieve, collecting a sieved particle, extruding, and pelletizing to obtain a medicine particle; taking 25-40 parts of urea, 10-20 parts of potassium chloride, 15-20 parts of zinc chloride, 30-45 parts of polyaspartic acid, mixing, pulverizing, screening by the 100-mesh sieve, collecting a sieved particle, extruding, and pelletizing to obtain a fertilizer particle; taking 5-12 parts of hyaluronic acid, 6-10 parts of polyacrylamide, and 5-12 partsof ethylene-vinyl acetate copolymer, stirring and mixing evenly for 20-30 minutes, adding 12-18 parts of sodium secondary alkyl sulfonate, 6-12 parts of sodium dodecylbenzene sulfonate and 20-30 partsof water, stirring for 15-20 minutes to obtain a compound coating emulsion; taking 5-10 parts of white gourd extract, 5-10 parts of medicine particle and 30-40 parts of fertilizer particle, mixing evenly, spraying the compound coating emulsion, drying to obtain the sustained release biological medicinal fertilizer. The sustained release biological medicinal fertilizer solves the problems that theexpiration date of the medicinal fertilizer is short at present and the too long expiration date causes reduced medicinal effect or failure.

The invention relates to a preparation method of sustained-release anthocyanin micro-capsules, and belongs to the field of micro-capsules. The preparation method of the sustained-release anthocyanin micro-capsules comprises the following steps of performing fixation treatment on petal raw materials; adding warm water so as to be subjected to thermal insulation, adding phenylalanine, edible salt and citric acid, carrying out beating after dissolving so as to obtain pulp, and carrying out filter-pressing so as to obtain filtrate; dissolving modified starch, casein and maltodextrin in the filtrate, and carrying out spray-drying so as to obtain micro-capsules I; dissolving casein-sodium and vitamin C in the filtrate, wrapping the micro-capsules I with the solution so as to obtain micro-capsules II; dissolving sodium alginate in the filtrate, wrapping the micro-capsules II with the solution so as to obtain micro-capsules III; and then, dissolving sodium alginate and maltodextrin in water, wrapping the micro-capsules III with the solution, and carrying out drying so as to obtain finished products of the sustained-release anthocyanin micro-capsules. According to the preparation method ofthe sustained-release anthocyanin micro-capsules, pretreatment is carried out in advance during extraction process of anthocyanin so as to reduce degradation of the anthocyanins, so that stability isenhanced; moreover, multilayer-wrapping is performed on anthocyanin particulates by using different wall materials, so that the embedding rate is increased with sustained-release effects enhanced. Thus usability of the sustained-release anthocyanin micro-capsules in functional products can be improved so as to promote play of physiological function.

The invention discloses a methylene blue antioxidant repair polymer nanofiber membrane and a preparation method, and relates to the technical field of repair dressings. The nanofiber membrane at leastcomprises a three-layer structure of a hydrogel layer, a nanofiber filament layer and hydrogel layers, wherein the hydrogel layer comprises chitosan and derivatives thereof, a gelatinizing natural polymer substance and a salt ion substance; the nanofiber filament layer is sandwiched between the two hydrogel layers, and the nanofiber filament layer is a non-water-soluble polymer filament membranewith a plant superfine fiber membrane as a skeleton; and methylene blue is uniformly distributed in the non-water-soluble polymer filament. By releasing methylene blue step by step, the action time iseffectively prolonged, the transdermal absorption capacity of methylene blue is strong, and the bioavailability is high. During use, a closed environment capable of continuously releasing methylene blue can be formed, a skin lesion part can be subjected to long-time antioxidant repair, and good antibacterial and anti-inflammatory effects are achieved.

The invention discloses an artificial biological floating island, which comprises a floating island unit or multiple floating island units connected into a whole. A plurality of through holes are formed in each floating island unit; planting containers for planting aquatic plants are arranged in the through hole; an upward groove is formed in a bottom surface of each floating island unit; a hollow-out cover plate is arranged on each groove. Vesuvianite and immobilized microorganisms are arranged in each groove. According to the artificial biological floating island provided by the invention, amulti-layer purification system is formed, and biological diversity is more remarkable through arranging plants and the microorganisms, and a purification capacity is further promoted through settingan oxygenation measure. A water body can be repaired in multiple directions from a water surface to water.

The invention discloses a sustained-release microsphere loaded with nimodipine and a preparation method thereof. The microsphere has a single core structure or a core-shell structure, the core material is composed of nimodipine solid dispersion and konjac glucomannan-calcium alginate, and the shell material is a chitosan-calcium alginate polyelectrolyte membrane. The preparation process mixes the nimodipine solid dispersion with konjac glucomannan-calcium alginate hydrosol, and uses the capillary breaking method to add CaCl dropwise 2 Aqueous solution or Chitosan-CaCl 2 In the aqueous solution, the obtained spheres are washed and dried to obtain drug-loaded konjac glucomannan-calcium alginate microspheres or drug-loaded konjac glucomannan-calcium alginate-chitosan microspheres. The present invention has the advantages of improving the bioavailability and slow-release effect of nimodipine; by changing conditions such as konjac glucomannan content, gel ion concentration, chitosan molecular weight and chitosan concentration, it is easy to realize drug control. Explanation; the preparation process is simple, the production cost is low, and it is easy to produce on a large scale.