6results about How to "Improve sustained release" patented technology

The invention provides a stable antibacterial peptide antibacterial coating and a preparation method and application thereof, and the method comprises the following steps: pretreating the surface of an orthopedic external fixation frame matrix, suspending in a simulated physiological solution containing polycarboxylate, treating at 60-100 DEG C for 1-24 hours, naturally cooling to room temperature, taking out a substrate material, cleaning, and drying to obtain the stable antibacterial peptide antibacterial coating. And suspending in a solution containing the antibacterial peptide for adsorption treatment, and then rinsing and airing to obtain the antibacterial coating of the stable antibacterial peptide. The antibacterial peptide can be effectively stabilized and prevented from being degraded too early, so that the antibacterial peptide is slowly released on the orthopedic external fixing frame to play a long-acting antibacterial effect. The method is easy to implement, the coating can provide long-acting antibacterial protection, the anti-infection capacity of the orthopedic external fixing frame is improved, the antibacterial duration of the orthopedic external fixing frame is prolonged, the postoperative infection risk is reduced, postoperative recovery of a patient is promoted, the biocompatibility and the antibacterial capacity of the orthopedic external fixing frame are remarkably improved, and a new direction is provided for improvement of orthopedic fixing instruments.

Disclosed is a pharmaceutical composition which can provide a tablet capable of maintaining the shape of the tablet for a long period of time after administration while suppressing the content of polyvinyl alcohol. The pharmaceutical composition contains a polyvinyl alcohol-based resin (A), a polyphenol compound (B), and amorphous silica (C). The content of the amorphous silica (C) is 0.1-20 parts by mass with respect to 100 parts by mass of the polyvinyl alcohol-based resin. Further disclosed is a tablet which comprises a pharmaceutical composition as a matrix composition (I) and an active pharmaceutical ingredient (II) dispersed in the matrix composition (I), the active pharmaceutical ingredient (II) being contained in an amount of 30-90 mass% inclusive.

This invention relates to an enzyme-responsive brain-targeting sustained-release formulation based on dialkylimidazolium biomimetic lipids, its preparation method, and its application, belonging to the field of drug delivery. First, dialkylimidazolium biomimetic lipids are covalently coupled with natural phospholipids to form a dialkylimidazolium conjugate. Then, this dialkylimidazolium conjugate is self-assembled with dialkylimidazolium biomimetic lipids, natural phospholipids, cholesterol, and a therapeutic drug to form a drug-loaded lipid nanoparticle delivery system. This drug delivery system can effectively cross the blood-brain barrier to achieve brain-targeted delivery of the loaded drug. In the glioma microenvironment, this drug delivery system can gradually hydrolyze the dialkylimidazolium conjugate through an enzyme-responsive mechanism to achieve sustained release of the loaded drug, providing a new strategy for improving the brain targeting and efficacy of different types of anti-glioma drugs, such as small nucleic acid drugs, peptide drugs, and small molecule drugs.

The present invention provides a sildenafil citrate orodisintegrating tablet and a preparation method thereof, and belongs to the field of medical technology. Icariin, tribulus saponin and sildenafil citrate are mixed to prepare liposomes, added to a hydrogel prepared from modified maltodextrin and earthworm protein, mixed evenly, dried, ground to obtain a mixed powder, added to an auxiliary material, and tableted to obtain a sildenafil citrate orodisintegrating tablet. The sildenafil citrate orodisintegrating tablet prepared by the present invention adopts a direct tableting method, has a simple preparation method, does not require coating, has good palatability, good stability, good therapeutic effect, has a good sustained-release effect, prolongs the drug effect time, improves the patient's compliance, and has broad application prospects.

The invention relates to the technical field of marine soil remediation, in particular to a marine concrete coating as well as a preparation method and application thereof. According to the marine concrete coating provided by the invention, the raw materials of the marine concrete coating comprise the cementing material, the sand and the benthic organism shell powder, and the benthic organism shell powder is added into a mixture of the cementing material and the sand, so that slow release of calcium ions in concrete can be promoted; the obtained marine concrete coating contains calcium ions with a certain concentration; calcium ions with proper concentration are favorable for inducing larvae of benthic organisms such as barnacles, sea squirts and the like to adhere and settle; the prepared marine concrete coating has higher compressive strength and tensile strength under the condition of maintaining the basic properties of cement, can achieve the effects of promoting adhesion and growth of benthic organisms, maintaining biodiversity and maintaining ecological balance in the using process, accelerates construction of marine organism communities, and improves the construction efficiency of the marine organism communities. And the damaged marine ecological environment is restored.

This invention relates to the field of food sauce technology, and more particularly to a wasabi and mushroom sauce and its preparation method. The wasabi and mushroom sauce is prepared from the following raw materials in parts by weight: 80-120 parts wasabi granules, 5-20 parts wasabi oil granules, 150-300 parts diced mushrooms, 30-60 parts edible oil, 10-30 parts sweetener, 8-12 parts edible salt, 4-10 parts thickener, and an appropriate amount of water. This invention combines wasabi granules with highly stable wasabi oil granules. The wasabi oil granules are obtained by solidifying a Pickering emulsion stabilized with sodium octenyl succinate starch / microcrystalline cellulose and hydrogenated palm oil, exhibiting excellent protection and sustained-release effects against isothiocyanates, etc. The added diced mushrooms enrich the chewy texture. The wasabi and mushroom sauce maintains a high ITC content after storage, with a long-lasting flavor and rich taste, combining the aroma of real wasabi, the umami of mushrooms, and a full-bodied chewy texture.