188 results about "Doxycycline hydrochloride" patented technology

The invention discloses a composition of animal doxycycline hydrochloride injection and a process for making the same, belonging to the animal medicine technical field. The injection consists of principal medicine, solvent, a doxycycline hydrochloride complexing agent and antioxidant, wherein metal ion (Mg<2+>) of higher content is used as the doxycycline hydrochloride complexing agent so as to remarkably increase the solubility and the pH value of the doxycycline hydrochloride and to reinforce the stability of the injection at the same time; above all, the toxicity and the tissue irritation of medicine are reduced after complexation. Dissolvant mixed by 2-pyrrolidone and propylene glycol or dimethyl acetamide is used as solvent so as to increase the stability of the injection; therefore, the injection can not be separated out and frozen under a low-temperature (4 DEG C) condition; moreover, concentrated hydrochloric acid and ethanolamine are used as pH regulator. The invention develops the high-content doxycycline hydrochloride injection for veterinary clinic, and the injection has advanced process, convenient use and remarkable curative effect.

The invention provides a preparation process of doxycycline hydrochloride. In the preparation process, 5-hydroxy-6-demethyl-6-desoxy-6-methylene-11-chlorotetracycline is pressurized and hydrogenated with hydrogen in the presence of catalyst-palladium / carbon (Pd / C) and adjuvant and then reacts with 5-sulfosalicylic acid to obtain alpha-6-doxycycline 5-sulfosalicylate; then alpha-6-doxycycline base is generated after basification; and finally the doxycycline hydrochloride is generated through salt transformation. The preparation process of the doxycycline hydrochloride has the advantages that the productivity and stereoselectivity are improved, the content of related substances in the finished product is reduced, and the high-quality finished product is obtained.

The invention discloses compound florfenicol injection for an animal. Every 1,000ml of the compound florfenicol injection contains 50 to 300g of florfenicol, 50 to 300g of doxycycline hydrochloride, 150 to 800g of organic solvent, 5 to 90g of complexing agent and 0.2 to 1g of antioxidant. The compound florfenicol injection has the advantages that: (1) the preparation is high in complexation degree and stable in quality, and the doxycycline hydrochloride injection is instable in property; (2) the injection is low in dosage and convenient to use, and the injection twice can be finished at one time; (3) the injection greatly saves the labor cost for veterinary medicine under an intensive feeding condition; and (4) the production of the preparation is controllable in terms of technical conditions, the injection is suitable for industrial production, various raw and auxiliary materials are needed to be accurately weighed in the production process, only the reaction temperature and the reaction time are needed to be controlled without any special technical requirement, and the production technology is easy to master and control.

The invention relates to compound tylosin injection for animals and a preparation method thereof. The injection consists of tylosin, doxycycline hydrochloride, trimethoprim, aminophylline, dexamethasone sodium phosphate, organic solvent and injection water. As a dedicated compound preparation for animals, the injection has special effect for treating respiratory tract infection caused by livestock and poultry sensitive bacteria and mycoplasmosis of pigs and poultry. The method has the advantages of convenient use, short course of treatment, low drug resistance and the like.

The invention discloses a preparation method for a doxycycline modified release pellet and preparation. The method includes the steps of: preparing a doxycycline hydrochloride drug loaded pellet, then mixing the pellet with an appropriate amount of a coating material, applying a fluidized bed to perform coating by bottom spraying, and carrying out drying to obtain the doxycycline hydrochloride modified release pellet; mixing auxiliary materials evenly, and mixing an adhesive with the auxiliary materials uniformly according to a weight ratio of 0.01-1:1; and under a molten state of the adhesive, sticking the auxiliary materials to the surface of the coated pellet prepared form doxycycline by the adhesive so as to obtain a pellet particle; and subjecting the pellet particle to direct tabletting, or mixing the pellet particle with a buffer particle prepared by a conventional method according to a weight ratio of 1:9-9:1 and then conducting tabletting, thus obtaining a pellet tablet. The preparation method provided by the invention is free of layering phenomenon in the tabletting process, and the prepared pellet tablet has uniform quality and drug content. Thus, the method is suitable for industrial production.

The invention relates to a doxycycline hydrochloride injection for animals and a preparation method for the doxycycline hydrochloride injection. The method comprises the following steps of: adding a proper amount of antioxygen and a proper amount of stabilizing agent into water for injection; then adding an aqueous solution into an organic solvent; adding doxycycline hydrochloride and a complexing agent; adjusting the pH; preserving the heat; then adding a metal ion chelant and partial antioxygen; and filtering, filling nitrogen and sterilizing to obtain the doxycycline hydrochloride injection for animals. The doxycycline hydrochloride injection prepared by the method is safe and stable; the half-life period is about 30 to 39 hours; the working time of the medicament in the body is prolonged, and the medicating frequency and the using amount are reduced; the treating effect and the treating efficiency are improved; and the doxycycline hydrochloride injection has a wide veterinary clinical application prospect.

The invention discloses doxycycline hydrochloride oil turbid liquor, a preparation method and application thereof. The doxycycline hydrochloride oil turbid liquor of the invention is obtained through preparing 50 to 300g of doxycycline hydrochloride raw medicine, 1 to 50g of suspending aids, 1 to 30g of surface active agents, 0.1 to 2g of oxidation inhibitors and a proper amount of oil into the oil turbid liquor with the volume amount of 1L. The doxycycline hydrochloride oil turbid liquor of the invention is prepared by a dispersing method, has the advantages of high stability, prolonged absorption time, delayed peak reaching time, prolonged elimination half life and good biocompatibility, and can be used as long-effect injection preparations for animals.

The invention discloses a preparation technology of doxycycline hydrochloride lyophilized powder for injection. The doxycycline hydrochloride prepared by the invention reduces the contents of toxicants including Beta-doxycycline and metacycline; the doxycycline hydrochloride for injection prepared from an injection-grade doxycycline hydrochloride is characterized by low acrimony, low irritability and low adverse reaction. The injection-grade doxycycline hydrochloride can be used for preparing medical preparation for intravenous injection, such as the doxycycline hydrochloride powder injection, lyophilized powder injection and injection liquid for in vivo injection and medication, and has the advantages of low acrimony, low irritability, low adverse reaction and the like.

The invention provides a broad-spectrum reagent used for preventing plant diseases, which is prepared by acetylsalicylic acid with a weight of 23 - 70 percent, moroxydine hydrochloride with a weight of 12 - 70 percent, doxycycline hydrochloride with a weight of 0 - 49 percent, indole-3-butyrate with a weight of being 0 - 4.5 percent, and alpha-naphthylacetic acid with a weight of 0 - 4.5 percent. The broad-spectrum reagent of the invention has the advantages of easy manufacturing, convenient use, obvious effect, and good safety for human and livestock, and is capable of being widely applied to preventing multiple plant diseases, such as jujube witches broom, and tobacco mosaic, etc.

The invention discloses a treatment method of waste liquor obtained after alcohol mother liquor purifying in doxycycline hydrochloride production. The treatment method comprises the following steps: (1) cooling: stirring and cooling the waste liquor to 40-45 DEG C in a regulating reservoir; (2) performing primary flocculation and sedimentation: adding a flocculating agent into cooled wastewater, and adding alkaline to neutralize after performing the flocculation and sedimentation, and mud-water separation; (3) performing secondary flocculation and sedimentation: performing filter-pressing on the liquid neutralized in the step (2) by virtue of a filter press, performing flocculation and sedimentation on filtrate again, and separating mud from water; (4) performing biochemical treatment: performing biochemical reaction on liquid supernatant obtained by mud-water separation through an ozone oxidation decoloration unit, an anaerobic treatment unit and an aerobic biochemical unit; (5) filtering and performing membrane separation: treating the liquid treated in the step (4) through a membrane bioreactor, a nanofiltration membrane and a reverse osmosis membrane. Compared with the prior art, the treatment method has the beneficial effects of high treatment efficiency, stable operation and capacity of eliminating the pollution of wastewater on the environment.

The invention discloses a synthesis process of doxycycline hydrochloride intermediate 11alpha-chlorinated methacycline. The technical scheme key point of the invention is as follows: in the synthesis process of doxycycline hydrochloride intermediate 11alpha-chlorinated methacycline, mixed acid of formic acid and 98% concentrated sulfuric acid is selected as a dehydrating agent. According to the improved way, anhydrous hydrofluoric acid in the tradition production is replaced by concentrated sulfuric acid frequently used in industrial production, the harm of the anhydrous hydrofluoric acid to the human body is reduced according to the improved process, the requirement on production equipment is reduced, the production cost is saved, and solvents used in the production can be recycled. On the environment aspect, the produced waste water is less, and the problem that fluorinion in the waste water is out of limits is eliminated. On the production operation aspect, the harm to an operator is small, and the operation is simple. And the yield is higher than the traditional synthesis process on the yield aspect.

The invention discloses a veterinary doxycycline hydrochloride injection and a preparation method thereof. 100 ml of injection mainly comprises the following components by weight: 10 to 30 g of doxycycline hydrochloride, 1 to 3 g of complexant, 1 to 5 g of cosolvent, 0.5 to 1 g of antioxidant, 10 to 30 g of antibacterial synergist, 30 to 60 g of organic solvent, 5 to 10 g of triethanolamine and the balance of water for injection. In the veterinary doxycycline hydrochloride injection of the invention, methoxybenzylaminopyrimidine compounds and sodium sulfate or sodium sulfite serving as synergists are adopted to be combined with the doxycycline hydrochloride so as to improve the complexation degree of the doxycycline hydrochloride and the complexant, reduce the temperature of complex reaction, and improve the stability of the doxycycline hydrochloride; and the methoxybenzylaminopyrimidine adopted by the invention is a synergist, can extend the maintenance time of effective blood concentration, improve pharmacodynamic action time, and avoid stress and inconvenience due to repeated medicament administration by a veterinarian.

The invention discloses a doxycycline hydrochloride pharmaceutical composition and a biomedical application thereof. The doxycycline hydrochloride pharmaceutical composition provided by the invention contains doxycycline hydrochloride and a natural product compound (I) which is separated from dry tuber of rhizoma alismatis and novel in structure. When doxycycline hydrochloride and the compound (I) are in effect independently, GSH content in mouse liver tissues can be improved, MDA content can be reduced, accumulation of TG is inhibited, and a certain liver protection effect is realized; and when doxycycline hydrochloride and the compound (I) are in combined effect, the liver protection effect is better, a drug used for protecting the liver can be developed, and substantial characteristics and obvious progress are shown compared with the prior art.

The invention relates to a method for preparing a standard substance for detecting antibiotics in cosmetics. The standard substance is formed by mixing aqueous solution of the antibiotics or solution of propylene glycol and cosmetic cream, wherein the cosmetic cream comprises the following components in percentage by weight: 73 to 78 percent of de-ionized water, 3 to 3.5 percent of propylene glycol and 0.2 to 0.25 percent of carbomer in phase A, 4.5 to 5 percent of stearate, 3 to 4 percent of cetyl alcohol and stearyl alcohol and 10 to 14 percent of 26# white oil in phase B and 1.2 to 1.25 percent of phenoxyethanol and ethylhexylglycerin in phase C; and the concentration of the antibiotics in the standard substance reaches 0.1g / 100mL. The method has the advantages that: the antibiotics and the cosmetic cream are mixed to form the standard substance for detecting the antibiotics such as minocycline hydrochloride, oxytetracycline dehydrate, tetracycline hydrochloride, chlortetracycline hydrochloride, doxycycline hydrochloride and chloramphenicol in the cosmetic; and the standard substance is the same as a sample of the cosmetic containing the antibiotics in the actual use; thus the detection of the antibiotics in the cosmetic conforms to the state of the actual application better and is more accurate.

The invention belongs to the field of pharmaceutical science, and particularly relates to a doxycycline hydrochloride dual-release preparation and a preparation method thereof. The preparation consists of micropills with different release performance, namely the preparation is formed by mixing 50 to 85 weight percent of quick-release micropill and 50 to 15 weight percent of sustained-release micropill. The preparation method comprises the following steps of: preparing micropill cores according to a formula, and preparing the quick-release micropills by using the micropill cores; preparing thesustained-release micropills by using the quick-release micropills; and filling the quick-release micropills and the sustained-release micropills into capsules in a ratio to obtain doxycycline hydrochloride dual-release capsules. Pharmacokinetic experiments in the dual-release capsule bodies indicate that medicines in the doxycycline hydrochloride dual-release capsules can be released twice when the doxycycline hydrochloride dual-release capsules are taken once every day, and the concentration of two-time peaks is close; the concentration peak of medicines in blood plasma is reduced by a dual-release model, the possibility of side effect is reduced, and the compliance of the administration of patients is improved; and due to the adoption of a new formula and a new process, the difference among batches is reduced, and the stability of samples is improved, so the doxycycline hydrochloride dual-release preparation is suitable for industrial production.

The invention discloses a compound medicinal composition for treating livestock and poultry respiratory disease and soluble powder thereof. The compound medicinal composition for treating the livestock and poultry respiratory disease mainly comprises the following components in part by weight: 1 to 3 parts of tiamulin hydrogen fumarate, 5 to 15 parts of doxycycline hydrochloride, 1 to 15 parts of astragalus polysaccharide and 1 to 4 parts of antisepsis synergist. In the compound medicinal composition for treating the livestock and poultry respiratory disease, the tiamulin hydrogen fumarate and the doxycycline hydrochloride are adopted, and the antisepsis synergist is added, so the antiseptic effect of the medicament is improved on the basis of maintaining the medicinal effects of the tiamulin hydrogen fumarate and the doxycycline hydrochloride, and the aims of high efficiency and quick response are fulfilled; besides, the added traditional Chinese medicinal component astragalus polysaccharide adjusts the physiological function of the livestock and poultry, improves the immunity of the livestock and poultry, and improves the antiseptic capacity of organisms of the livestock and poultry.

The invention discloses a compound trimethoprim and doxycycline hydrochloride nanoemulsion preparation. The nanoemulsion preparation is of an oil-in-water type, and the grain size of the nanoemulsion preparation is between 1nm and 100nm. The nanoemulsion preparation is prepared from the following raw materials in weight percentage: 0.01-1.75 percent of trimethoprim, 0.04-6.99 percent of doxycycline hydrochloride, 21.8-35.7 percent of surfactant, 7.94-11.9 percent of cosurfactant, 3.49-4.76 percent of oil and the balance of distilled water. The compound preparation is an oil-in-water type nanoemulsion; the compound preparation is flaxen and transparent in appearance; the grain size of the compound preparation is between 1nm and 100nm, so that the stability is high; and the trimethoprim and the doxycycline hydrochloride in the preparation show up an obvious synergistic effect, The compound nanoemulsion preparation has the advantages of safety, broad spectrum, high efficiency, targeting and slow release.

The invention discloses a doxycycline long-acting injection which has the formula as follows: 5g to 20g of doxycycline, 10g to 60g of propylene glycol, 2g to 4g of MgCl2, 0.2g to 0.5g of Na2S2O5, and water used for injection. The preparation method comprises the following steps: 1. the doxycycline is added into the propylene glycol to obtain a solution (1); 2. the doxycycline hydrochloride, the MgCl2 and the Na2S2O5 are taken and dissolved in the water used for injection to obtain a solution (2); 3. the solution (2) is slowly added into the solution (1) and stirred while being added, and ethylene diamine is used for regulating the pH value to be 7.5 to 8.5; and 4. the water used for injection is added till the total volume reaches 100ml, and filtering, encapsulation and flowing steam sterilization at the temperature of 100 DEG C for 30min are carried out to obtain the finished product. The doxycycline long-acting injection has the advantages of less dosage, long half-life period, less adverse reaction, and the like.

The invention relates to an application of sustained-release material sucrose acetate iso-butyrate used in in-situ gel preparations to preparation of an oil suspension injection for livestock, and in particular relates to a method used for preparing a doxycycline hydrochloride long-acting injection by combining sucrose acetate iso-butyrate and hydrogenated castor oil or aluminium stearate. A dispersion medium of the preparation is isopropyl myristate, benzyl benzoate, ethyl oleate or a mixture of more than one of isopropyl myristate, benzyl benzoate and ethyl oleate. The preparation has good sustained release effects, stable characters and good tissue compatibility, and is easy to prepare.

The invention discloses a method for synthesizing a doxycycline hydrochloride intermediate alpha-6-doxycycline through hydrogenation on the basis of a silica gel rhodium catalyst. The invention adopts the key technical scheme that the method comprises the following steps: (1), a rhodium complex is loaded on functionalization silica gel to prepare the silica gel rhodium catalyst; (2), the prepared silica gel rhodium catalyst is dispersed into an organic solvent, methacycline or the salt of the methacycline is used as a raw material, hydrogen is introduced, and the reaction lasts for 4 to 12 hours under the conditions that the pressure is 0.4 to 2.5 MPa and the reaction temperature is 40 to 120 DEG C, so that the doxycycline hydrochloride intermediate alpha-6-doxycycline is prepared. The silica gel rhodium catalyst in the invention has high catalytic activity and enantio selectivity and can be used for doxycycline hydrochloride production process, the yield can reach more than 60 percent, the content of beta-isomer is only 0.03 percent to 0.10 percent, the reaction condition is mild, the reaction directionality is excellent, side reactions are less, and the catalyst can be reduced, so that the production cost is lowered and the industrial production is facilitated.

The invention discloses a preparation method of tylosin tartrate-doxycycline hydrochloride pharmaceutical composition, which comprises the following steps: dissolving a high molecular material in an organic solvent to prepare a dispersion medium; respectively adding tylosin tartrate powder and doxycycline hydrochloride powder to the dispersion medium slowly, heating, stirring, dissolving and then cooling to respectively obtain a tylosin tartrate microsphere suspension and a doxycycline hydrochloride microsphere suspension; and centrifuging, filtering, washing and drying the dispersion microsphere suspension to obtain microspheres. The weight ratio of the tylosin tartrate microspheres to the doxycycline hydrochloride microspheres is 3-4:1 counted by tylosin to doxycycline, and the microspheres are mixed uniformly and adjuvant is added to prepare soluble powder, particles and oral liquid. The pharmaceutical composition prepared in the invention has good curative effect, covers up the bitterness of the medicine, and is favorable for livestock and fowl to take.

The invention discloses an oily long-acting injection containing doxycycline hydrochloride / poloxamer 407 drug-loading particles, which is prepared by combining the doxycycline hydrochloride with poloxamer 407 into drug-loading particles and further dispersing the drug-loading particles into an oily medium and grinding. Hydroxypropyl methyl cellulose or high-substituted hydroxypropyl cellulose also can be added into the drug-loading particles, and the sustained-release effect of the preparation is obviously enhanced. The preparation process of the injection is simple, the drug release is uniform, the biocompatibility is good, irreversible damage to the tissue of the injection part is avoided, and the adopted sustained-release carrier can be degraded and excreted.

The invention relates to a compound doxycycline hydrochloride injection for veterinary use and a preparation method thereof. The raw materials comprise doxycycline hydrochloride, thiamphenicol, dexamethasone sodium phosphate, trimethoprim, diclofenac sodium, organic solvent and water for injection. As a special compound preparation for veterinary use, the injection has obvious curative effects on infectious diseases caused by gram-positive bacteria, gram-negative bacteria and mycoplasma, quickly takes effects after the injection is injected into livestock with the diseases, and has special efficacy on mixed infection and severe diseases caused by various pathogenic bacteria and viruses. After intramascular for animals, the injection is easily absorbed, takes effect for a long time and causes little local stimulation. The injection has the advantages of convenient use, short treatment course, low drug resistance, and the like.

A doxycycline hydrochloride liposome with high optical and thermal stability, high power to pass through skin and mucosa, and high antibacterial effect is prepared from phosphatide, cholesterol, doxycycline hydrochloride and emulsifier by film dispersing method, injection method, or reverse evaporation method.

The invention belongs to the technical field of veterinary drug preparation, and relates to a compound doxycycline-hydrochloride florfenicol sustained-release microsphere suspension injection for veterinary use. The suspension injection is produced through a preparation technology combining an inclusion technology, a microcapsule technology and a high-pressure homogenization technology. The suspension injection comprises the following ingredients according to W / V: 10-30% of an inclusion material, 5-20% of doxycycline hydrochloride, 5-20% of florfenicol, 2.5-7.5% of a high-molecular capsule material, 0.2-1% of a suspending agent, 0.25-1% of an anti-oxidant, 0.05-0.2% of a metal chelator, 0.1-0.4% of an antiseptic, and the balance injection water. The active ingredients in the injection possess synergic antibacterial effects and obvious sustained release effect, clinic dosing frequency is reduced, the injection does not contain organic solvents, does not stimulate target animals, is small in toxic and side effects, and is capable of controlling respiratory diseases caused by streptococcus suis, actinobacillus pleuropneumoniae, pasteurella multocida, haemophilus parasuis, mycoplasma and the like.

The invention provides a method for preventing saprolegniasis of fish fertilized eggs in order to overcome shortcomings in the prior art. The method includes: using a fine balance scale to accurately weigh 0.5g of doxycycline hydrochloride powder which is dissolved in 200ml of water to be figured into 0.25% of a stock solution; using a transfer pipette to accurately add 0.5ml (5ppm) or 1.0ml (10ppm) or 2.0ml (20ppm) of the stock solution of doxycycline hydrochloride to a culture vessel containing the fertilized eggs and 250ml of aerated tap water for hatching. The method is simple in operation, the saprolegniasis is effectively prevented, and hatching rate of the fertilized eggs is increased.

The invention discloses a preparation method of a doxycycline hydrochloride intermediate hydride. The preparation method comprises adding dried oxytetracycline chloride into a dehydration pot containing HF, carrying out reaction dehydration, carrying out standing, evaporating and concentrating to remove HF, collecting the concentrated solution through methanol, neutralizing the methanol solution containing the concentrated solution through calcium hydroxide or calcium oxide powder, carrying out a hydrogenation reaction process on the neutralized methanol solution in the presence of a Pd / C catalyst and an inhibitor, filtering the reaction product, and carrying out a salt formation reaction process on the filtrate and a sulfonyl salicylate methanol solution to obtain the doxycycline hydrochloride intermediate hydride. The preparation method is free of p-toluenesulfonic acid, has simple processes, can be operated easily and greatly reduces a production cost.

The invention discloses medicine for preventing the systemic infection of aquatic animals, which relates to the field of aquaculture, in particular to medicine for preventing aquatic animal diseases. The technical contents of the invention are as follows: each 100g of the medicine by weight parts comprise 8 to 12 parts of florfenicol, 10 to 30 parts of doxycycline hydrochloride, 10 to 20 parts of garlicin and the balance starch. The invention provides western compound medicine for preventing the systemic infection of aquatic animals for aquaculture, is characterized by quickness, significant therapic effect and little residue, can condition the organism of aquatic animals, effectively treat the systemic infection of aquatic animals caused by various diseases, such as enteritis, gill rot and red skin so that the organism of the aquatic animals is recovered normally, so as to greatly improve the medicine effect, and reduce the labor intensity of farmers and the farming cost of aquatic animals.

A freeze-dried powder injection of doxycycline hydrochloride is proportionally prepared from doxycycline hydrochloride, VC and glycine through dissolving them in the water for injection, adding the water for injection, stirring, adding medicinal carbon, stirring, coarse filtering to remove carbon, fine filtering by filtering membrane, pouring in container, and freeze-drying.

The invention relates to a compound doxycycline hydrochloride composition for preventing and treating colibacillosis and chronic respiratory disease of poultry as well as a preparation method of the compound doxycycline hydrochloride composition. The compound doxycycline hydrochloride composition is prepared by uniformly mixing the following components by weight: 10-15 parts of doxycycline hydrochloride, 10-20 parts of colistin sulfate, 5-15 parts of tylosin tartrate, 5-10 parts of trimethoprim lactate and 40-70 parts of anhydrous dextrose. The compound doxycycline hydrochloride composition has the beneficial effects of reasonable formula, easiness in preparation, remarkable treatment effect and clinically proven special effect for treating colibacillosis and chronic respiratory disease of the poultry.