29 results about "Doxycycline hydrochloride" patented technology

This invention discloses a powder containing doxycycline hydrochloride and potassium clavulanate for aquaculture, its preparation method, and its application, belonging to the field of biotechnology. This invention combines doxycycline hydrochloride and potassium clavulanate to enhance the antibacterial ability of aquatic animals against drug-resistant bacteria, thereby better treating various diseases caused by drug-resistant bacteria in aquatic animals. Further experiments demonstrate that potassium clavulanate can significantly reduce bacterial resistance and enhance the antibacterial activity of doxycycline hydrochloride. The preparation of a composite powder using the combination of doxycycline hydrochloride and potassium clavulanate is simple, uses readily available raw materials, and is suitable for large-scale industrial production. Its application in the treatment of aquatic animal diseases, verified through challenge experiments, demonstrates the effectiveness of this composite powder in treating bacterial infections in aquatic animals. It has broad application prospects.

The present application belongs to the technical field of veterinary medicine, and provides a poultry medicine composition for preventing and treating avian viral respiratory disease and a preparation method thereof. The poultry medicine composition for preventing and treating avian viral respiratory disease is composed of a Qingjie mixture and doxycycline hydrochloride. The present application produces a synergistic effect between components through the combined application of traditional Chinese medicine and western medicine, enhances the drug efficacy, and has a remarkable effect in treating avian viral respiratory disease.

The invention discloses a preparation method and application of a carbon quantum dot-doped fluorescent probe, and relates to the technical field of fluorescent probes, the preparation method comprises the following steps: using 3, 4-difluorophenylboronic acid and ethylenediamine as precursors, and treating the precursors by a one-step hydrothermal method to prepare a boron, fluorine and nitrogen co-doped carbon quantum dot fluorescent probe BFN-CQDs; wherein the addition amount ratio of the 3, 4-difluorophenylboronic acid to the ethylenediamine is 0.18-0.22 g: 0.18-0.22 ml, the one-step hydrothermal method adopts ultrapure water to be mixed and stirred with the 3, 4-difluorophenylboronic acid and the ethylenediamine to react, and the addition amount ratio of the ultrapure water to the 3, 4-difluorophenylboronic acid is 8.5-9.5 ml: 0.18-0.22 g. The application has the effect of preparing the carbon quantum dot doped fluorescent probe which can be directly used for detecting the content of doxycycline hydrochloride in a water sample, the preparation method is simple, the detection is rapid, efficient and quantitative, and the application is wide in application prospect. The carbon quantum dot-doped fluorescent probe has the effects of stable performance, strong anti-interference capability and high doxycycline hydrochloride content detection accuracy during application.

The invention provides a preparation method of a doxycycline hydrochloride veterinary preparation. Wherein each 100 g of the preparation contains 10 to 20 g of doxycycline hydrochloride, 10 to 15 g of antibacterial peptide blap-6, a proper amount of ethanol, 25 to 35 g of an adhesive, 5 to 10 g of a disintegrating agent, 1 to 5 g of a flow aid and the balance of a diluent. The solid-liquid-solid conversion step is adopted, and compared with an existing doxycycline hydrochloride preparation aqueous solution, the stability is better under illumination, and the in-vitro antibacterial performance is better.

The invention discloses silk fibroin-tannic acid esterified microspheres as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The preparation method comprises the following steps: firstly, dissolving silk fibroin and tannic acid in a mixed solvent of N, N-dimethylformamide and water to form a precursor solution, adding a condensing agent DMTMM, stirring at normal temperature to carry out esterification reaction, and after the reaction is completed, carrying out centrifugal washing to obtain microspheres; the DMTMM is utilized to efficiently catalyze the esterification reaction in a water phase, the process is green and mild, and the use of a toxic cross-linking agent is avoided; the prepared microspheres are uniform in particle size, good in dispersity and high in stability, and due to introduction of tannic acid, the microspheres are endowed with inherent antioxidant, antibacterial and tissue adhesion properties; the prepared microspheres are loaded with the periplaneta americana extract and the doxycycline hydrochloride and have high drug loading capacity, slow release characteristic and good biocompatibility, and the microspheres with target effects such as antibacterial, antioxidant and healing promoting functions can be obtained through drug loading.

The invention provides application of epiberberine, palmatine hydrochloride and a composition of epiberberine and palmatine hydrochloride as an antibacterial synergist. The method comprises the following steps: firstly, respectively researching in-vitro antibacterial effects of epiberberine and palmatine hydrochloride on Escherichia coli; then the in-vitro antibacterial effect of the epiberberine and palmatine hydrochloride combined antibacterial drug (enrofloxacin and doxycycline hydrochloride) on the escherichia coli is researched respectively, and then the in-vitro antibacterial effect of the epiberberine and palmatine hydrochloride combined antibacterial drug (enrofloxacin and doxycycline hydrochloride) on the escherichia coli is researched.

The application discloses doxycycline for injection and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The preparation contains doxycycline hydrochloride, polyethylene glycol-poly (caprolactone) and other raw materials, vitamin C phosphate is used to replace vitamin C, and an 'acid phosphatase-GSH' double-reducing agent hierarchical response nano-carrier is constructed. The preparation is prepared through an organic phase, an aqueous phase, homogenization, evaporation, centrifugation and other steps. The problems of poor stability of doxycycline and lack of specificity of release are solved, the storage period is extended to 36 months, the release at an infected site reaches 85% in 48 hours, the release at normal tissue is less than 20%, and precise targeted drug release is realized.

The invention discloses a doxycycline monohydrate cyclic preparation method based on an isopropanol aqueous solution system, and belongs to the technical field of compound preparation. The method comprises the following steps: preparing an isopropanol aqueous solution with the volume fraction of 90-95%, and filling ammonia gas into the isopropanol aqueous solution to prepare an isopropanol aqueous solution containing 2-2.5 wt% of ammonia; the preparation method comprises the following steps: mixing doxycycline hydrochloride and an isopropanol aqueous solution of ammonia at a certain temperature, stirring until the solution is clear, adjusting the pH value, then heating and preserving heat, and separating out doxycycline monohydrate crystals; and filtering, washing the solid with an isopropanol aqueous solution, drying to obtain a doxycycline monohydrate, and distilling the mother liquor to obtain an azeotrope which is recycled as a raw material. According to the invention, the doxycycline hydrochloride and the isopropanol aqueous solution of ammonia are used as raw materials, the finished doxycycline monohydrate with low solvent residue is prepared by strictly controlling the reaction process and parameters, the product is stable in quality and high in purity, and the impurity content is obviously lower than the European and American standards.

The invention relates to the technical field of degradation of hydrodynamic cavitation catalysis, in particular to a degradation device based on hydrodynamic cavitation catalysis and an antibiotic wastewater degradation method thereof, and the degradation device comprises the following steps: S1, adding antibiotic-containing wastewater into a liquid storage tank, and adding a preset amount of catalyst to enable the catalyst and the wastewater to form a uniform solid-liquid mixture, meanwhile, stirring and temperature control preparation is carried out on the liquid storage tank; s2, a water pump is started, so that the solid-liquid mixture enters a Venturi cavitation generator through a main circulation pipeline, a hydrodynamic cavitation effect is formed in a contraction section, a throat part and a diffusion section of the Venturi cavitation generator, and circulating flow is completed; the synthesized ternary ZIS / NFO / BC catalyst has the advantages of being high in stability, resistant to chemical corrosion, resistant to light corrosion and the like, and compared with a single hydrodynamic cavitation process or a single photocatalysis process, the hydrodynamic cavitation catalysis synergistic degradation process greatly improves the degradation efficiency of antibiotic doxycycline hydrochloride.

The invention relates to the technical field of pharmaceutical compositions, and particularly discloses a pharmaceutical composition for animal parasite expelling and a preparation method and application thereof. The pharmaceutical composition comprises the following raw material components in parts by mass: 15-30 parts of a traditional Chinese medicine extracting solution, 5-10 parts of doxycycline hydrochloride, 1-5 parts of vitamin C and 1-5 parts of mannan oligosaccharide, wherein the traditional Chinese medicine extracting solution comprises the following raw material components: a dark plum extracting solution, a pepper extracting solution, a wild buckwheat extracting solution, a gemma agrimoninae extracting solution, a rhizoma smilacis glabrae extracting solution and a cortex phellodendri extracting solution. The pharmaceutical composition for animal parasite expelling provided by the invention not only has an excellent parasite expelling effect, but also has the advantages of safe raw material components, no toxic or side effect on animal bodies, and difficult generation of drug resistance. According to the technical scheme, the problems that in the prior art, drugs for preventing and treating animal parasitic diseases are large in toxic and side effects, prone to generating drug resistance, poor in parasite expelling effect and narrow in prevention and treatment range are effectively solved.

The application discloses a preparation method of rod-shaped doxycycline hydrochloride and relates to the technical field of medicine preparation. The preparation process comprises the following steps: S1, preparing a mixed solvent: mixing and uniformly stirring methanol and water to obtain a mixed solvent, which is prepared for use; S2, dissolving raw materials and adding an additive: adding doxycycline hydrochloride raw materials into the mixed solvent obtained in the step S1, stirring until completely dissolved, and adding a eutectic solvent and polyvinylpyrrolidone into the mixed solvent to obtain a doxycycline hydrochloride solution; S3, crystallization: under stirring, the temperature is reduced to 3-8 DEG C at a rate of 0.3-1.0 DEG C / min, and crystallization is carried out for 2-4 hours; and S4, separation and purification: after the crystallization is completed, filter cake is obtained through reduced-pressure filtration, and the filter cake is dried to obtain rod-shaped doxycycline hydrochloride. The doxycycline hydrochloride product obtained by the preparation method has a regular rod shape, a length-diameter ratio of about 2-3:1, uniform particle size distribution and good preparation processing performance.

The invention discloses an offspring seed cultivation method for artificial propagation of light botia superba, and belongs to the technical field of aquaculture. The fry breeding method comprises the steps that doxycycline hydrochloride, MS222, multivitamins and ginger paste are added during parent fish transportation, and a two-stitch method is adopted for spawning induction during artificial spawning induction. The two-needle method comprises the following steps: firstly, injecting luteinizing hormone releasing hormone A2 and domperidone maleate into female fish; and secondly, injecting luteinizing hormone releasing hormone A2, domperidone maleate and chorionic gonadotropin into the female fish, and synchronously injecting luteinizing hormone releasing hormone A2 and domperidone maleate into the male fish. According to the method, the artificial propagation of the botia reevesii is realized, the induced spawning rate is greater than or equal to 90%, the fertilization rate is greater than or equal to 90%, the hatching rate is greater than or equal to 92%, the fry survival rate is greater than or equal to 88%, and the transportation death rate The method provides reliable technical support for resource protection, large-scale production, development and utilization of the botia delavayi.

The invention discloses a low-cost environment-friendly method for preparing doxycycline hydrochloride, and belongs to the technical field of organic compound synthesis. The method comprises the following steps: filtering a doxycycline hydrochloride hydrogenation reaction solution while the solution is hot, and carrying out reduced pressure distillation on the filtrate to obtain doxycycline mixed salt; carrying out salt conversion reaction on the doxycycline mixed salt, and separating to obtain doxycycline hydrochloride and salt conversion mother liquor; p-toluenesulfonic acid with relatively high purity can be obtained by treating the salt conversion mother liquor, and the p-toluenesulfonic acid can be used for preparing the 11alpha-chloro-6-methylene oxytetracycline p-toluenesulfonate. Hydrogenation reaction liquid is directly subjected to vacuum concentration after being filtered while hot, additional heat supply is not needed in the process, effective control over energy consumption is achieved through optimization of process steps, and production energy consumption is remarkably reduced; in the hydrogenation reaction salification stage, the addition of sulfosalicylic acid is abandoned, and the consumption of the raw material is effectively avoided, so that the purchase cost of the raw material is greatly reduced, and the production economy is improved.

The invention discloses a green preparation method of high-yield and high-purity doxycycline hydrochloride. The method comprises the following steps: dissolving a doxycycline hydrochloride crude product in a water-acetone mixed solvent, filtering, and adjusting the pH to separate out doxycycline free alkali; and dissolving free alkali in an ethanol-acetone mixed solvent, adding acid to form salt, and adding seed crystal to crystallize to obtain the high-purity doxycycline hydrochloride. Preferably, the refined mother liquor is recycled after being adsorbed by activated carbon. The product purity is greater than or equal to 99.5%, the key impurity content is low, the yield is high, the solvent usage amount is reduced, and the method is suitable for industrial production.

The invention relates to the technical field of doxycycline hydrochloride tail gas treatment, in particular to an anti-blocking structure based on a doxycycline hydrochloride tail gas conveying pipeline and a mounting method of the anti-blocking structure. Comprising a pipeline outer protection layer and temperature sensors, the temperature sensors used for monitoring the internal temperature of the pipeline outer protection layer are installed in the pipeline outer protection layer at equal intervals, the pipeline outer protection layer comprises a heat preservation shell, a spiral electric tracing and a filling layer are fixedly connected into the heat preservation shell, and a tail gas conveying internal pipe is installed in the heat preservation shell; the tail gas conveying inner pipe comprises a straight pipe and a bent pipe, and connecting flanges are welded and fixed to the top ends of the straight pipe and the bent pipe. A plurality of single-slope damping washers are adopted for synchronous buffering at the connecting and fixing position, it can be guaranteed that all the positions are stressed the same, and in the vibration environment, the stability of the connecting positions can be guaranteed; and the stress of the sealing gasket used at the joint can be ensured to be unchanged all the time, so that the problem of sealing failure at the joint caused by anisotropic deformation of the sealing gasket can be prevented.

The invention relates to the technical field of medicines, in particular to stable and efficient doxycycline hydrochloride soluble powder and a preparation method thereof. The efficient and stable doxycycline hydrochloride soluble powder is prepared from composite cyclodextrin, an enteric polymer, beta-carotene and a ginkgo leaf extract. Through beta-cyclodextrin and hydroxypropyl-beta-cyclodextrin composite inclusion and enteric polymer wrapping technologies, the inclusion rate is increased, protection on phenolic hydroxyl groups / enol hydroxyl groups in doxycycline is enhanced, oxidation and hydrolysis are reduced, targeted release of intestinal tracts is realized, and drug failure caused by gastric acid stimulation is avoided.

This invention relates to the field of doxycycline hydrochloride and colistin sulfate preparations, and provides an injection solution of doxycycline hydrochloride and colistin sulfate and its preparation method. The injection solution comprises the following raw materials at final concentrations: doxycycline hydrochloride 0.02-0.05 g / mL, colistin sulfate 0.01-0.03 g / mL, antioxidant 0.003-0.005 g / mL, solubilizer 30-50 mL / 100 mL, complexing agent 0.02-0.05 g / mL, and the balance being water. The injection solution of this invention can cover a wider spectrum of pathogens, improve the efficiency and safety of clinical treatment, and ensure the safety of the injection solution when used at high doses, effectively solving the problems of poor stability and high toxicity of existing similar injection solutions. Therefore, this application provides an injection solution with good stability, low toxicity, significant efficacy, and broad application prospects.

The invention belongs to the technical field of veterinary drug preparation, and discloses a synergistic doxycycline hydrochloride effervescent tablet as well as a preparation method and application thereof. The effervescent tablet is prepared from the following raw and auxiliary materials in percentage by weight: 10-15% of doxycycline hydrochloride, 3-5% of composite essential oil microcapsules, 3-7% of bletilla striata polysaccharide, 7-10% of Arabic gum, 1-3% of lauryl sodium sulfate, 38-42% of an effervescing agent, 5-6% of an adhesive, 4-5% of a disintegrating agent, 2-3% of a lubricant and the balance of a filling agent, wherein the weight percentage of the raw and auxiliary materials is 100%. The effervescent tablet prepared by the invention can be completely disintegrated after encountering water, can generate a large number of bubbles and is high in disintegration speed, the contact area between the medicine and an inflammation part is effectively enlarged, the microcapsules can be well adhered to the inner walls of the uterus and the vagina after absorbing water and expanding, the retention time of the medicine is prolonged, and the medicine effect is more lasting. The effervescent tablet is applied to treatment of bovine vaginitis and endometritis, the cure rate can reach 90% or above, and the effervescent tablet is suitable for being applied to intensive large-scale farms.

The invention belongs to the technical field of analytical chemistry, and provides a method for synchronously detecting colistin sulfate and doxycycline hydrochloride in a compound preparation, which comprises the following steps: (1) preparing a mobile phase; (2) preparing a colistin sulfate standard series solution and a doxycycline hydrochloride standard series solution, detecting the standard series solutions by using a high performance liquid chromatography, and drawing a standard curve of colistin sulfate and a standard curve of doxycycline hydrochloride; (3) preparing a to-be-loaded sample solution; and (4) detecting the to-be-loaded sample solution by using a high performance liquid chromatography, and substituting the peak areas of colistin sulfate and doxycycline hydrochloride into the standard curve obtained in the step (2) to obtain the concentration values of colistin sulfate and doxycycline hydrochloride in the to-be-loaded sample solution. According to the technical scheme, by optimizing the gradient elution procedure, doxycycline hydrochloride and various colistin sulfate can be detected at the same time, sample detection can be completed within 15 minutes, and the time cost and reagent consumption are remarkably reduced.

The invention relates to inclusion synergistic type doxycycline hydrochloride soluble powder. 100kg of the soluble powder is mainly prepared from the following raw materials in a weight ratio: 10 to 30kg of doxycycline hydrochloride, 20 to 40kg of beta-cyclodextrin, 3 to 8kg of lauryl sodium sulfate, 0.8 to 1.2 kg of lysozyme freeze-dried powder, 2 to 3kg of sodium ascorbate, 8 to 12kg of microcrystalline cellulose and 15 to 45kg of lactose. The soluble powder can effectively avoid inactivation caused by direct contact between lysozyme and an organic solvent, improves the slow release performance of drugs, and meets the national policy requirements of resistance reduction.

The invention relates to a tablet discharging device of a tablet press for doxycycline hydrochloride tablets and a preparation process. According to the tablet discharging device of the tablet press, a tablet discharging groove is provided with a feeding port and a discharging port, the groove bottom of the tablet discharging groove inclines downwards in the discharging direction, the tablet discharging groove pivots at least three elastic pieces rotating between a first position and a second position, and the elastic pieces are staggered and divide the tablet discharging groove into a primary separation cavity and at least two subseparation cavities in the discharging direction; the groove bottom of the primary separation cavity and the groove bottom of the fine separation cavity are each provided with a set of screening holes with the diameter smaller than that of tablets, and the elastic pieces are arranged on the sides, close to the discharging opening, of the screening holes; a plurality of magnetic ground brushes, fixed magnetic field generators and alternating magnetic field generators are arranged in the primary separation cavity and the secondary separation cavity; when the tablets are intercepted by the elastic piece, the brush rolls under the action of the alternating magnetic field to clean medicine powder on the tablets, and when the tablets are released, the brush is adsorbed in the tablet outlet groove by the fixed magnetic field. According to the tablet discharging device, medicine powder can be effectively removed in time, so that the uniformity of the tablet coating effect is high.

The invention provides a doxycycline hydrochloride rapid analysis system and method based on automatic detection, and the system comprises an automatic sample injection module which is used for automatically mixing a to-be-detected sample and a fluorescent probe according to a preset proportion, and injecting the mixture into a microfluidic reaction path; the multi-channel signal acquisition module is used for synchronously acquiring multi-mode detection signals such as fluorescence, scattered light and temperature; the fusion model module is used for performing feature extraction and fusion analysis on the acquired multi-channel signals and generating an optimal adjustment instruction; the closed-loop execution module is used for automatically adjusting detection parameters based on model output and realizing dynamic closed-loop control in the detection process; and the result output module is used for outputting a doxycycline hydrochloride concentration judgment result and can be used for collecting user feedback to assist the iterative optimization of the model. The method has the advantages of high automation degree, high detection speed, high result accuracy and strong anti-interference capability.

The invention discloses doxycycline for injection and a preparation method thereof, and belongs to the field of pharmaceutical preparations. The preparation contains doxycycline hydrochloride, polyethylene glycol-polycaprolactone and other raw materials, vitamin C phosphate is used for replacing vitamin C, and the'acid phosphatase-GSH 'dual-reducing-agent graded response nano-carrier is constructed. The preparation method comprises the following steps: preparing an organic phase and a water phase, homogenizing, evaporating, centrifuging and the like. The problems of poor stability and lack of release specificity of doxycycline are solved, the storage period is prolonged to 36 months, the release rate of an infected part within 48 hours reaches 85%, the release rate of a normal tissue is less than 20%, and accurate targeted drug release is realized.

The invention relates to high-stability doxycycline hydrochloride soluble powder which mainly comprises the following components in percentage by weight: 10-50% of doxycycline hydrochloride, 30-50% of a buffer system, 1-10% of an antioxidant / metal ion chelating system, 4-12% of an acidifying agent and the balance of a filling agent. Through the synergistic effect of a pH buffer system and an antioxidant / metal ion chelating system, the chemical stability of doxycycline in different water qualities (especially slightly alkaline and high-hardness water) is doubly guaranteed. Experiments prove that the effective content of the product in tap water with the pH value of 8.0 is reduced by less than 5% within 24 hours, while the effective content of a common preparation is reduced by more than 70%.

The present application relates to the technical field of pharmaceutical preparation, and in particular to a florfenicol-doxycycline compound preparation and a preparation method thereof.The raw materials of the florfenicol-doxycycline compound preparation include, by mass fraction, 5-10 parts of florfenicol, 5-20 parts of doxycycline hydrochloride, 20-40 parts of inclusion material, 8-14 parts of pullulan, 1-3 parts of nano-silicon dioxide, 1-5 parts of glycerol, 1-2 parts of emulsifier, 0.1-0.3 parts of genipin, 20-60 parts of filler, 0.1-1 parts of surfactant, and 0.1-1 parts of lubricant.The present application combines the use of florfenicol and doxycycline hydrochloride, and the effect is better than that of single use;meanwhile, the granulation method and the auxiliary materials used improve the solubility of florfenicol, and the florfenicol-doxycycline compound preparation can be administered by mixed feeding or drinking water, and is convenient for clinical use.

The invention relates to the technical field of doxycycline hydrochloride tail gas treatment, in particular to a spraying absorption tower system for doxycycline hydrochloride tail gas and a using method thereof.The spraying absorption tower system comprises a spraying tower body, a precipitation assembly is installed in the spraying tower body through a connecting piece, and a gas inlet pipe is installed on one side of the precipitation assembly; one-way rotating worm wheel blades are mounted in the air inlet pipe; an air pipe is mounted at the lower end of the air inlet pipe; the precipitation assembly comprises a precipitation shell, a distribution assembly is mounted at the lower end of the interior of the precipitation shell, and corresponding overflow holes which are annularly distributed at equal intervals are formed in the outer side and the inner side of the upper end of the precipitation shell. According to the spray tower, the treatment mode of combining treatment of trace antibiotic raw materials or product powder and filtrate treatment is firstly carried out, the precipitated trace antibiotic raw materials or product powder can be precipitated in the precipitation shell and is shunted through the annular filtering net, the phenomenon that the powder enters the bottom of the spray tower can be avoided, and the maintenance period of the spray tower is prolonged.

The application discloses a core-shell nanoflower BaTiO3 / In2S3 heterojunction with an S-shaped energy band structure and a preparation method and application thereof, and the preparation method comprises the following steps: step one, preparing carboxylated BaTiO3 nanoparticles; step two, adding the carboxylated BaTiO3 nanoparticles, an indium salt, C2H5NS and CH4N2O into distilled water, and then stirring on a magnetic stirrer to obtain a first mixed solution; step three, transferring the first mixed solution into an autoclave, and then obtaining a second mixed solution after heating reaction; step four, naturally cooling the second mixed solution to room temperature, and then obtaining the BaTiO3 / In2S3 heterojunction after washing, centrifugation and drying; and the core-shell nanoflower BaTiO3 / In2S3 heterojunction with the S-shaped energy band structure is applied to degradation of doxycycline hydrochloride, degradation of rhodamine B and reduction of Cr(VI) reaction as a photocatalyst, and a better degradation effect can be obtained.

The utility model discloses a finished product refrigerated cabinet for doxycycline hydrochloride injection, which relates to the technical field of refrigerated cabinets and comprises a cabinet body, a partition layer is mounted in the cabinet body and divides the interior of the cabinet body into a working area and a mounting area, a plurality of partition plates are mounted in the working area, and the mounting area is mounted in the working area. A plurality of partition plates are arranged in the cabinet body and divide the working area into a plurality of independent refrigeration areas, a plurality of cabinet doors are hinged to the outer side of the cabinet body, the cabinet doors are used for sealing the refrigeration areas and are in one-to-one correspondence with the refrigeration areas, a dehumidification mechanism is arranged in the mounting area, the dehumidification mechanism comprises a single-machine rotating wheel dehumidifier, and a dehumidification box is further arranged in the mounting area. The doxycycline hydrochloride injection drying device is beneficial to reasonable storage of doxycycline hydrochloride injections, is better in drying effect, can assist workers in storing medicines in different periods and batches, and is beneficial to improving the working efficiency of the workers.

The invention provides doxycycline hydrochloride for injection and a preparation method thereof.The doxycycline hydrochloride for injection comprises doxycycline hydrochloride, vitamin C, mannitol, an inclusion material and sodium lauroyl sarcosinate, and the preparation process comprises the steps that the inclusion material and doxycycline hydrochloride are dissolved in water for injection respectively, a doxycycline hydrochloride solution is slowly added into an inclusion material solution, stirring is carried out for 1-2 h, and a mixture is obtained; and sequentially adding vitamin C, mannitol and sodium lauroyl sarcosinate into the water for injection, dissolving, adding into the inclusion solution, uniformly mixing, adjusting the pH value to 5-7, fixing the volume, filtering, filling and freeze-drying. The preparation product provided by the invention has the characteristics of good stability, low irritation, fast redissolution, good clinical use compliance, stable curative effect and the like.