2 results about "Doxycycline hydrochloride" patented technology

This invention discloses a powder containing doxycycline hydrochloride and potassium clavulanate for aquaculture, its preparation method, and its application, belonging to the field of biotechnology. This invention combines doxycycline hydrochloride and potassium clavulanate to enhance the antibacterial ability of aquatic animals against drug-resistant bacteria, thereby better treating various diseases caused by drug-resistant bacteria in aquatic animals. Further experiments demonstrate that potassium clavulanate can significantly reduce bacterial resistance and enhance the antibacterial activity of doxycycline hydrochloride. The preparation of a composite powder using the combination of doxycycline hydrochloride and potassium clavulanate is simple, uses readily available raw materials, and is suitable for large-scale industrial production. Its application in the treatment of aquatic animal diseases, verified through challenge experiments, demonstrates the effectiveness of this composite powder in treating bacterial infections in aquatic animals. It has broad application prospects.

The application discloses a preparation method of rod-shaped doxycycline hydrochloride and relates to the technical field of medicine preparation. The preparation process comprises the following steps: S1, preparing a mixed solvent: mixing and uniformly stirring methanol and water to obtain a mixed solvent, which is prepared for use; S2, dissolving raw materials and adding an additive: adding doxycycline hydrochloride raw materials into the mixed solvent obtained in the step S1, stirring until completely dissolved, and adding a eutectic solvent and polyvinylpyrrolidone into the mixed solvent to obtain a doxycycline hydrochloride solution; S3, crystallization: under stirring, the temperature is reduced to 3-8 DEG C at a rate of 0.3-1.0 DEG C / min, and crystallization is carried out for 2-4 hours; and S4, separation and purification: after the crystallization is completed, filter cake is obtained through reduced-pressure filtration, and the filter cake is dried to obtain rod-shaped doxycycline hydrochloride. The doxycycline hydrochloride product obtained by the preparation method has a regular rod shape, a length-diameter ratio of about 2-3:1, uniform particle size distribution and good preparation processing performance.