85 results about "Natural phospholipids" patented technology

A liposome of breviscapine for preparing the medicines to cure cerebral thrombus and coronary heart disease is prepared from breviscapine, phosphatide, cholesterol, and supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch, etc by different methods. Its advantages are high absorption rate, high biologic utilization rate, and high stability.

The invention discloses a natural L-alpha-glycerophosphocholine (GPC) and a preparation method thereof. The natural GPC is prepared from the following raw materials in parts by mass: 1 part of lecithin, 5-20 parts of low carbon alcohol and 0.1-0.4 part of catalyst. The preparation method comprises the following steps: adding lecithin into a three-neck flask with condensation reflux, dissolving the lecithin in low carbon alcohol, and heating in a heat-collection isothermal-heating magnetic stirrer to 20-100 DEG C; proportionally adding a catalyst, and stirring to react for 2-15 hours; evaporating the mixed solution after reaction; and dissolving the product in low carbon alcohol, and precipitating with a nonpolar solvent, thereby obtaining the natural phospholipid deacylated substance mainly comprising GPC or GPE. The invention has the advantages of mild reaction conditions, short reaction time and high product purity; the nonionic organic amine catalyst, especially low-boiling amine, is easy to separate and is nontoxic, so that the production technique is easy to process, thereby simplifying the preparation technique and ensuring the safety of the product used in functional food additives, health products medicines.

The present invention relates to a lipid-based drug delivery system for administration of a lysolipid derivative present in a prodrug from, said prodrug furthermore being a substrate for extracellular phospholipase A2 to the extent that an organic radical can be hydrolytically cleaved off, whereas the aliphatic group of the lysolipid derivative remains substantially unaffected, said system having included therein lipopolymers or glycolipids so as to present hydrophilic chains on the surface of the system. Particularly interesting lipid derivatives are lipids in which the head group is linked to the C-2 position and the organic radical (a drug substance) is covalently attached to the C-3 position of the glycerol moiety. Pharmaceutical compositions comprising the drug delivery system can be used in diagnosis and targeted treatment of various disorders, e.g. cancer, infectious, and inflammatory conditions, etc., i.e. disorders and diseases associated with or resulting from increased levels of extracel lular PLA₂ activity in the diseased tissue.

The invention provides a natural phospholipid compound greasing agent and a preparation method thereof. The natural phospholipid compound greasing agent consists of natural phospholipid, sulfitation neat's foot oil and fatty alcohol phosphate. The natural phospholipid compound greasing agent for greasing can improve the waterproof performance and fullness of leather and achieve satisfying greasing effect; and the natural phospholipid compound greasing agent is suitable for greasing light color leather due to light color. The method for preparing the natural phospholipid compound greasing agent comprises the following steps of: (1) heating natural phospholipid to between 50 and 70 DEG C, adding a compound decolorizing agent into the natural phospholipid, fully reacting the mixture for 3 to 4 hours, and then adding the following components in percentage by weight into the mixture: 7 to 10 percent of compound emulsifying agent, 7.5 to 10 percent of sulfitation neat's foot oil and 7.5 to 10 percent of fatty alcohol phosphate; keeping the temperature between 50 and 70 DEG C, stirring the components for 1 hour and mixing the components uniformly; (2) adding 30 percent sodium hydroxide solution into the grease mixture to perform neutralization, and adjusting the pH value to between 6.0 and 8.0; and (3) slowly adding a certain amount of distilled water (preheated to 80 DEG C) into the mixture to keep the oil content between 48 and 52 percent, and fully stirring the mixture for 2 to 5 hours to obtain the modified phospholipid compound greasing agent.

The invention provides a method for preparing a filling leather fatliquoring agent, comprising the following steps: (1) a component A and a component B or a component A, a component B and a component C undergo copolymerization in the presence of initiators, wherein the component A is at least one of natural oil containing unsaturated fatty acid, long carbon chain unsaturated fatty acid, ester of long carbon chain unsaturated fatty acid and long carbon chain unsaturated fatty acid amide; the component B is at least one of acrylic acid, methacrylic acid, ethyl acrylic acid, maleic acid, fumaric acid, glutaconic acid, vinyl acetic acid, maleic anhydride and glutaconic acid anhydride; and the component C is at least one of styrene, vinylacetate, vinyl propionate, acrylate, methacrylate, acrylamide and methacrylamide; (2) alkali is added in polymers generated after copolymerization to undergo neutralization reaction with the polymers; and (3) the neutralized polymers are mixed with the natural phospholipids. The method is economical and environmentally friendly.

The invention discloses a water-soluble electric contact lubricating protective agent improving the pluggable resistance of an electronic element and a use method thereof. The water-soluble electric contact lubricating protective agent comprises the following components in parts by weight: 10-15 parts of fatty alcohol and inositol phosphate, 3-6 parts of natural phospholipid, 3-8 parts of corrosion inhibitor, 10-20 parts of composite surfactant system, 15-25 parts of chelating agent, and 10-20 parts of detergent. A protective agent is adopted to lubricate the electronic element, and the protective agent is firstly diluted by 10-100 times with pure water, and preferably 100/8-100/4. Soaking technology is adopted for lubrication, the temperature is 20-60 DEG C, the time is 30-90 seconds, the drying temperature of a workpiece subjected to lubrication is 80-150 DEG C, and the time is 30-120 seconds. After the electronic element is treated by the protective agent disclosed by the invention, through a pluggable force test, an abrasion test and a salt fog test, the results show that the friction of the electronic element is obviously reduced, the pluggable resistance is obviously enhanced, and the long-term reliability of products is obviously improved.

The invention discloses a preparative method for curcumin liposome suitable clinical and mass production and its frozen powder injection, the mass percent for curcumin and natural lipin is 10-60, and for compound one is 1-6, forming frozen powder injection in accordance with percent of 1 lipin and 0.5-2 freeze-dried excipient added.

A vinpocetine lipid with high absorptivity, biologic utilization rate and stability for treating cardiovascular and cerebropathy caused by senility is prepared proportionally from vinpocetin, phosphatide, cholesterol and the supporting agent chosen from sorbitol, mannitol, cane sugar, sodium chloride, water-soluble starch etc.

The production method of fish juice milk beverage uses the silver carp and big head fish as raw material, and includes the following steps: electrical stunning and killing fresh fish, descaling and removing gill, gutting, making the gutted fish into fish muscle pulp liquor, secondary electric shocking said fish muscle pulp liquor, separating it into fish fat pulp and fish protein pulp, adding natural phospholipid protein into fish fat pulp as microcapsule, at the same time zymolyzing fish protein pulp, mixing two pulps, making homogenization and superfine micronization treatment to obtain emulsion liquor, making vacuum flash evaporation, deaeration and sterilization treatment.

The invention discloses a preparation method and application of bay oil and nano-silver embedded liposome/chitosan antibacterial and antioxidant coating liquid. The preparation method comprises the steps that a lignin-coated nano-silver antibacterial agent is prepared by adopting lignin as a reducing agent, natural phospholipid or synthetic phospholipid and cholesterol as a lipid bilayer matrix, and oil-soluble bay oil as an antioxidant enhancer are compounded with the lignin-coated nano-silver antibacterial agent so as to prepare bay oil and nano-silver embedded multifunctional liposome; andthen the multifunctional liposome and a chitosan solution are mixed so as to prepare the coating liquid. When the bay oil and nano-silver embedded liposome/chitosan antibacterial and antioxidant coating liquid is applied to food packaging, the bay oil with an antioxidant effect has a good and lasting antioxidant effect; and lignin-coated nano-silver has a good antibacterial effect and is slowly released, and therefore the toxicity of the lignin-coated nano-silver in the food application is greatly reduced, and the potential hazards to human bodies are reduced.

The invention belongs to the technical field of medicines, discloses flexible nanoliposomes with a procyanidine and a preparation method for the flexible nanoliposomes, solves the problem of the low in-vivo stability of the procyanidine, and optimizes the formula and preparation process of the flexible nanoliposomes with the procyanidine. The flexible nanoliposomes are prepared by the procyanidine and auxiliary materials such as phospholipid and a surfactant; the phospholipid serving as a membrane material can be on-sale commercial phospholipid and comprises natural phospholipid and synthesized phospholipid; the surfactant can be cholates and the like; the mass ratio of the phospholipid to the medicine is 5:1-50:1; the mass ratio of the phospholipid to the surfactant is 2:1-10:1; the probe ultrasonic time is 1 to 20min; and the preparation method is a film dispersion method. The flexible nanoliposomes prepared by the preparation method are relatively small in particle size, high in stability, simple, stable and feasible in preparation process and have a good transdermal function.

This invention relates to a topotecan liposome and its preparation method. The preparation can be used as therapeutic drug of multiple tumours such as non-small cell lung cancer, liver cancer, stomach cancer, hematopathy, and lymphomata. The topotecan liposome is characterised in containing topotecan and at least one biologic receivable phospholipid at a weight ratio of 1:0.5. The phospholipid is selected from one of natural phospholipid, hydrogenated soybean phosphatide, and synthesized phospholipid. The liposome can also contain cholesterol and supported reagent. The supported reagent is selected from one of glucose, mannit, sucrose, sorbitol, dextran, lactose, and trehalose. The weight ratio of phospholipid and supported agent is 1:0.01-500. The preparation method comprise film dispersion, injection, ultrasonic dispersion, lyophilization, freeze thawing, forceful discharging, preparing with a viscolizer, and preparing through microjet under high pressure.

The invention discloses a brain targeting liposome and the process for preparing brain targeting liposome pharmaceutical preparation, wherein the brain targeting liposome pharmaceutical preparation comprises medicament, various synthesized or natural phosphatide with brain targeting function as liposome coating material, cephalin having brain tissue absorption accelerating agent, liposome coating material, sphingomyelin with brain tropism and immunity activation, cholestrin for liposome coating material and liposome stabilizing agent, vitamin E as anti-oxidizing agent and polyoxyethylene glycols and phosphatide derivative for extending the half-decay time of liposome pharmaceutical blood.

A method for preparing a nano-liposome food flavor comprises the steps as follows: a, 5-50 parts by mass of natural phospholipid molecules are dissolved in 100 parts by mass of an ethanol solution with mass concentration of 1%-20% to form a first solution; b, 5-30 parts by mass of polyethylene glycol modified lipid molecules are dissolved in 100 parts by mass of an ethanol solution with the mass concentration of 1%-20% to form a second solution; c, 20-80 parts by mass of polylactic acid and 10-80 parts by mass of food flavor are magnetically stirred and dissolved in 10-50 parts by mass of an organic solvent to form a third solution; d, the second solution and the third solution are slowly added in the first solution to obtain a food flavor solution; and e, the food flavor solution is subjected to ultrafiltration centrifugation and dialysis and then is homogenized or/and extruded by a high-pressure homogenizer or/and a high-pressure extruder so as to obtain the nano-liposome food flavor. The nano-liposome food flavor prepared with the method is stable in system, long in fragrance remaining time and high in fragrance concentration.

The present invention is oryzanol liposome with high absorption, high bioavailability and high stability and its preparation. The oryzanol liposome or oryzanol liposome precursor is prepared with oryzanol and phosphatide, cholesterol, supporting agent and other supplementary material. It has phosphatide/medicine weight ratio of 0.1-40, and is prepared through ethanol injecting process, film dispersion process, inverse evaporation process, extruding process or mechanical process. The supporting agent may be sorbitol, mannitol, cane sugar, etc. and has ratio to phosphatide of 0.01-400. The oryzanol liposome can act selectively on the autonomic nerve system of interbran and the center of endocrine system to improve autonomic nerve system, endocrine system and psychonerve. It is suitable for treating neurosis, climacteric syndrome, etc., and may be used in the assisting treatment of vascular headache and cerebral concussion sequelae.

The invention provides a modified phospholipid fat-liquoring agent and a preparation method thereof. The modified phospholipid fat-liquoring agent can improve the water resistance and flexibility of leather through fat liquoring, has a light color and is suitable for the fat liquoring of light color leather. The preparation method of the modified phospholipid fat-liquoring agent comprises the following steps of: (1) adding natural phospholipid, mineral oil and an acylating agent, raising the temperature to be between 90 and 100 DEG C, and reacting for 3 to 5 hours; (2) reducing the temperature to be between 50 and 60 DEG C, adding an antioxidant, stirring for 0.5 to 1 hour, adding a neutralizing agent, regulating the pH value to be between 6 and 8, adding an alcohol solvent, a modified surfactant and a preservative in turn, keeping the temperature of between 50 and 60 DEG C, and stirring for 1 to 1.5 hours; and (3) slowly adding a certain amount of distilled water to ensure that oil content is between 85 and 90 percent, and fully stirring for 2 to 5 hours to obtain the modified phospholipid fat-liquoring agent. The method is relatively simple, low in equipment requirement and short in production period.

The invention discloses low-temperature-resistant phospholipase D derived from Antarctic bacteria and a preparation method and application thereof. The amino acid sequence of the low-temperature-resistant phospholipase D is shown as SEQ ID NO: 3; and the gene sequence of the low-temperature-resistant phospholipase D is shown as SEQ ID NO: 2. An escherichia coli recombinant expression strain of the low-temperature-resistant phospholipase D is obtained, by means of the strain, a large amount of soluble expression of recombinant protein can be achieved, and later purification and protein obtaining are easy. The expression product has good low-temperature storage stability and good enzyme activity, and meanwhile has certain tolerance to organic solvents and surfactants. The obtained phospholipase D can be suitable for phospholipid modification, phosphatidic acid and various natural rare phospholipid and non-natural phospholipid compounds are produced, and the phospholipase D is applied to the fields of biology, food, medicine, cosmetics, agriculture, industry and the like.

The invention provides a sunscreen mist spray which comprises the following raw materials: methoxy-cinnamic acid ethylhexyl acrylate, octocrilene, bi-ethyl hexyloxyphenol methoxyphenyl triazine, butylmethoxy-dibenzoyl methane, natural phospholipid, absolute ethyl alcohol, titanium dioxide, zinc oxide, polydimethylsiloxane, polydimethylsiloxane, an emulsifier, 1,2-pentanediol, disodium hydrogen phosphate, sodium alginate, mannitol, sodium hyaluronate and water. A preparation method comprises the following steps: firstly, preparing lipidosome from chemical sunscreen agents, and together with physical sunscreen agents, preparing the sunscreen mist spray. By adopting the sunscreen mist spray, on one hand, irritation of the chemical sunscreen agents to skin can be reduced, on the other hand, the sunscreen agents can be uniformly clung to the surface of skin, the action time of the chemical sunscreen agents is prolonged, the overall sunscreen effect of the mist spray is greatly improved, and the use amount of the mist spray can be reduced.

The invention discloses liquid crystal nano gel capsules for treating colon cancer. The liquid crystal nano gel capsules comprise, by weight, 2-6% of anticancer active substances, 8-14% of poloxamer,40-60% of natural phospholipid, 25-30% of fatty glyceride and 5-10% of cosolvent. The anticancer active substances include camptothecin and further comprise at least two of taxol, docetaxel and adriamycin, and the weight of camptothecin accounts for 40-75% of total weight of the anticancer active substances. The invention further provides a preparation method of the liquid crystal nano gel capsules. The preparation method includes: well mixing other raw materials, adding the anticancer active substances, performing ultrasonic dispersion, preparing a liquid crystal gel precursor nano preparation into lyophilized powder, and filling capsule shells with the lyophilized powder to obtain the capsules. Encapsulation rate and drug loading capacity of liquid crystal gel are increased to greatest extent, and the liquid crystal nano gel capsules are high in drug release degree and good in targeting performance and anticancer effect.

The invention discloses UHT single cream and a preparation method thereof. Raw materials comprise the following components: 41.45-48.49 percent of butter, 3.5-4.5 percent of albumen powder, 3-4 percent of fat globule membrane powder, and 0.01-0.05 percent of stabilizer, and the content of water is 45-50 percent; the preparation method comprises the following steps: (1) uniformly mixing the albumen powder, the fat globule membrane powder and water to obtain a mixture A; (2) uniformly mixing the mixture A, the butter and the stabilizer to obtain a mixture B; (3) homogenizing the mixture B, performing UHT sterilization, and quickly cooling, thus obtaining the UHT single cream. According to the UHT single cream and the preparation method thereof, technical parameters and the raw materials are mutually cooperated, an emulsification effect is good, and the single cream is rich in natural phospholipid component, has the functions such as softening blood vessels and promoting human health, has a higher nutritional property, has better stability, keeps better application performance during the shelf life, has the shelf life of 6-9 months, avoid the phenomena such as fat floating, and has better storage stability and application prospect.

The invention discloses a liquid crystal gel nanoparticle freeze-dried powder capsule for treating a gastric ulcer and a preparation method thereof. The liquid crystal gel nanoparticle freeze-dried powder capsule is prepared from the following components in parts by weight: 3.5 to 5.5 parts of active pharmaceutical ingredient, 3.5 to 4.8 parts of drug combination, 23 to 27 parts of natural phospholipid, 37 to 45 parts of fatty glyceride, 7 to 9 parts of poloxamer, 11.4 to 14.2 parts of cosolvent and 3.3 to 5.8 parts of freeze-drying protecting agent, wherein the active pharmaceutical ingredient is at least one of pantoprazole, omeprazole, lansoprazole and bismuth potassium citrate; the drug combination comprises amoxicillin and clarithromycin. The invention also provides the preparation method of the liquid crystal gel nanoparticle freeze-dried powder capsule. The preparation method comprises the following steps of firstly preparing a liquid crystal gel nano precursor, then freeze-drying the liquid crystal gel nano precursor to make into freeze-dried powder, and finally making into the capsule. A liquid crystal gel nanoparticle of the liquid crystal gel nanoparticle freeze-dried powder capsule can be used for co-loading drugs with different polarity; the activity and synergistic action of the drugs are enhanced; the overall drug effect is improved; the slow release effect is good; the duration of the drug effect is long, and the drugs are small in size, more convenient to take and longer in storage period.

The invention relates to a preparation method of a softening agent for hard and dry leather cultural relics. The preparation method specifically comprises the following steps: adding lactic acid and hydrogen peroxide into natural phospholipid, and heating and stirring to modify; then, titrating to neutral by sodium hydroxide liquor and drying to obtain hydroxylated modified phospholipid; and finally, compounding phospholipid with hydrophilic amino silicon oil, tea saponins and deionized water to prepare a softening agent product. The preparation method provided by the invention has the advantages of strong pertinence, remarkable effect, harmlessness to cultural relics and the like.

The invention relates to a preparation method of an almond full-nut plant protein beverage. The preparation method of the almond full-nut plant protein beverage comprises the following steps of step 1, boiling 0.02-0.1 part of unshelled almond nuts with boiled water for at least 10 minutes, removing skins, and then soaking in a citric acid water solution at normal temperature for 2-7 hours for softening and color protection, thereby obtaining the fresh skin-removed white nuts; step 2, grinding the fresh skin-removed white nuts obtained in the step 1 into a pulp body; step 3, adding an emulsification stable solution prepared by a high-shearing emulsifying device into the pulp body obtained in the step 2, and mixing; step 4, adding purified water so as to form 1 part of almond beverage raw material, adjusting the pH value of the raw material to 7.2-7.8, and mixing uniformly; and step 5, homogenizing the almond beverage raw material which is mixed uniformly, sterilizing, and cooling. According to the invention, natural functional food materials such as pea protein isolate and phospholipid serve as emulsification stable factors, and not only are functional characteristics of high plant protein and high natural phospholipid endowed to products, but also the colloidal stability of almond protein and unsaturated lipid at high temperature and low temperature are also ensured.

The invention discloses a method for improving ovalbumin emulsibility through composite modifying. The method comprises the following steps of dissolving ovalbumin in a phosphate buffer solution to prepare a protein solution of which the mass concentration is 0.5-2%; treating a liposome dispersed solution by a micro jet method, and controlling the average particle diameter of liposome to be smaller than 100nm and compounding the ovalbumin with natural phospholipid in the mass ratio of the ovalbumin to the natural phospholipid being (10 to 1)-(10 to 20) to obtain ovalbumin and liposome so as toobtain an ovalbumin and liposome compound; and further treating the ovalbumin and liposome compound by the micro jet method, and performing freeze drying on samples to obtain the modified ovalbumin,wherein the emulsibility of the obtained ovalbumin is notably improved. Through adoption of interaction of biomacromolecule and nanoparticles, the ovalbumin and the liposome are compounded, and through assistance of the micro jet method, the emulsibility of the composite modified ovalbumin is treated. The method has the characteristics that the preparation technology is simple, and the preparationcondition is easy to control. The emulsibility of the obtained protein product is notably improved, and the application of the ovalbumin to foods is facilitated.