Liquid crystal gel nanoparticle freeze-dried powder capsule for treating gastric ulcer and preparation method thereof

The technology of freeze-dried powder and capsule is applied in the pharmaceutical field of treating gastric ulcer, which can solve the problems of easy oxidation of drugs in contact with air, affecting drug treatment effect, short duration of drug effect, etc., so as to prolong the treatment effect and duration, improve the Overall efficacy, the effect of reducing the volume of the drug

Active Publication Date: 2018-07-20
武汉百纳礼康生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Traditional gastric ulcer drugs are directly exposed to the air and are oxidized, which seriously affects the drug activity. After taking traditional capsules, the drug effect lasts for a short time, which increases the daily drug dosa

Method used

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  • Liquid crystal gel nanoparticle freeze-dried powder capsule for treating gastric ulcer and preparation method thereof
  • Liquid crystal gel nanoparticle freeze-dried powder capsule for treating gastric ulcer and preparation method thereof
  • Liquid crystal gel nanoparticle freeze-dried powder capsule for treating gastric ulcer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A liquid crystal gel nanoparticle freeze-dried powder capsule for the treatment of gastric ulcer provided in this embodiment comprises the following components in parts by weight: 4 parts of active pharmaceutical ingredients, 4.2 parts of combined drugs, 25 parts of natural phospholipids, fatty acid glycerol 41 parts of ester, 8 parts of poloxamer, 13 parts of cosolvent, 4.8 parts of lyoprotectant.

[0030] The active pharmaceutical ingredients are pantoprazole and omeprazole, and the weight ratio of the two is 5:4.4; the combined drug is amoxicillin and clarithromycin, and the weight ratio of the two is 5.4:4.6; The natural phospholipids are soybean phospholipids and lecithin E80, and the weight ratio of the two is 3:2; the fatty acid glycerides are monoolein and diolein, and the weight ratio of the two is 3:7; The poloxamer is poloxamer 401 and 407, and the weight ratio of the two is 1:1; the co-solvent is 85% propylene glycol aqueous solution; the lyoprotectant is ma...

Embodiment 2

[0036] This example is basically the same as Example 1, except that the liquid crystal gel nanoparticle freeze-dried powder capsule for the treatment of gastric ulcer provided by this example comprises the following active pharmaceutical ingredients in parts by weight: 3.5 parts, 4.8 parts of combined medication, 23 parts of natural phospholipids, 45 parts of fatty acid glycerides, 9 parts of poloxamers, 11.4 parts of cosolvents, and 3.3 parts of lyoprotectants.

Embodiment 3

[0038] This example is basically the same as Example 1, except that the liquid crystal gel nanoparticle freeze-dried powder capsule for the treatment of gastric ulcer provided by this example includes 5.5 parts by weight of the following active pharmaceutical ingredients, 3.5 parts of combined medication, 27 parts of natural phospholipids, 37 parts of fatty acid glycerides, 7 parts of poloxamers, 14.2 parts of cosolvents, and 5.8 parts of lyoprotectants;

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Abstract

The invention discloses a liquid crystal gel nanoparticle freeze-dried powder capsule for treating a gastric ulcer and a preparation method thereof. The liquid crystal gel nanoparticle freeze-dried powder capsule is prepared from the following components in parts by weight: 3.5 to 5.5 parts of active pharmaceutical ingredient, 3.5 to 4.8 parts of drug combination, 23 to 27 parts of natural phospholipid, 37 to 45 parts of fatty glyceride, 7 to 9 parts of poloxamer, 11.4 to 14.2 parts of cosolvent and 3.3 to 5.8 parts of freeze-drying protecting agent, wherein the active pharmaceutical ingredient is at least one of pantoprazole, omeprazole, lansoprazole and bismuth potassium citrate; the drug combination comprises amoxicillin and clarithromycin. The invention also provides the preparation method of the liquid crystal gel nanoparticle freeze-dried powder capsule. The preparation method comprises the following steps of firstly preparing a liquid crystal gel nano precursor, then freeze-drying the liquid crystal gel nano precursor to make into freeze-dried powder, and finally making into the capsule. A liquid crystal gel nanoparticle of the liquid crystal gel nanoparticle freeze-dried powder capsule can be used for co-loading drugs with different polarity; the activity and synergistic action of the drugs are enhanced; the overall drug effect is improved; the slow release effect is good; the duration of the drug effect is long, and the drugs are small in size, more convenient to take and longer in storage period.

Description

technical field [0001] The invention belongs to the pharmaceutical field for treating gastric ulcer, in particular to a liquid crystal gel nano particle freeze-dried powder capsule for treating gastric ulcer and a preparation method thereof. Background technique [0002] Gastric ulcer is a common digestive tract disease. Although there are many causes, it is mainly caused by Helicobacter pylori infection. With the improvement of people's living standards and the prolongation of life expectancy, people's awareness of the prevention and treatment of gastric ulcer is constantly increasing. Therefore, gastric ulcer is becoming one of the important research topics in the medical circles all over the world. In the Western medicine treatment of gastric ulcer, pantoprazole, omeprazole, lansoprazole, bismuth potassium citrate are common therapeutic drugs, in order to improve the therapeutic effect, select amoxicillin, clarithromycin, metronidazole etc. for combined medication. [...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K9/19A61K9/127A61K47/24A61K47/14A61K47/10A61K31/4439A61K31/43A61K31/7048A61P1/04
CPCA61K9/1274A61K9/19A61K9/48A61K31/43A61K31/4439A61K31/7048A61K47/10A61K47/14A61K47/24A61K2300/00
Inventor 罗亮黄丽萍孟凡玲
Owner 武汉百纳礼康生物制药有限公司
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