Liquid crystal gel nanoparticle freeze-dried powder capsule for treating gastric ulcer and preparation method thereof

Abstract

The invention discloses a liquid crystal gel nanoparticle freeze-dried powder capsule for treating a gastric ulcer and a preparation method thereof. The liquid crystal gel nanoparticle freeze-dried powder capsule is prepared from the following components in parts by weight: 3.5 to 5.5 parts of active pharmaceutical ingredient, 3.5 to 4.8 parts of drug combination, 23 to 27 parts of natural phospholipid, 37 to 45 parts of fatty glyceride, 7 to 9 parts of poloxamer, 11.4 to 14.2 parts of cosolvent and 3.3 to 5.8 parts of freeze-drying protecting agent, wherein the active pharmaceutical ingredient is at least one of pantoprazole, omeprazole, lansoprazole and bismuth potassium citrate; the drug combination comprises amoxicillin and clarithromycin. The invention also provides the preparation method of the liquid crystal gel nanoparticle freeze-dried powder capsule. The preparation method comprises the following steps of firstly preparing a liquid crystal gel nano precursor, then freeze-drying the liquid crystal gel nano precursor to make into freeze-dried powder, and finally making into the capsule. A liquid crystal gel nanoparticle of the liquid crystal gel nanoparticle freeze-dried powder capsule can be used for co-loading drugs with different polarity; the activity and synergistic action of the drugs are enhanced; the overall drug effect is improved; the slow release effect is good; the duration of the drug effect is long, and the drugs are small in size, more convenient to take and longer in storage period.

Description

technical field [0001] The invention belongs to the pharmaceutical field for treating gastric ulcer, in particular to a liquid crystal gel nano particle freeze-dried powder capsule for treating gastric ulcer and a preparation method thereof. Background technique [0002] Gastric ulcer is a common digestive tract disease. Although there are many causes, it is mainly caused by Helicobacter pylori infection. With the improvement of people's living standards and the prolongation of life expectancy, people's awareness of the prevention and treatment of gastric ulcer is constantly increasing. Therefore, gastric ulcer is becoming one of the important research topics in the medical circles all over the world. In the Western medicine treatment of gastric ulcer, pantoprazole, omeprazole, lansoprazole, bismuth potassium citrate are common therapeutic drugs, in order to improve the therapeutic effect, select amoxicillin, clarithromycin, metronidazole etc. for combined medication. [...

AI Technical Summary

Problems solved by technology

[0005] Traditional gastric ulcer drugs are directly exposed to the air and are oxidized, which seriously affects the drug activity. After taking traditional capsules, the drug effect lasts for a short time, which increases the daily drug dosage. Mixing of various drugs with different polarities often results in uneven mixing. , which seriously affects the therapeutic effect of the drug; the drug is easily oxidized when exposed to air, has poor stability, and is not easy to store

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