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596 results about "Amoxicillin" patented technology

Amoxicillin is used to treat a wide variety of bacterial infections.

Method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue

InactiveCN103713056AImprove linearitySimple processing and analysisComponent separationSulfur drugSulfanilamide
A disclosed method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue comprises: performing homogenate on an animal tissue sample by 50% acetonitrile and ethanol, performing ultrasonic extraction and hexane purifying, and performing further precipitation by acetonitrile and ethanol, concentrating, utilizing UPLC-MS / MS to perform multi-reaction monitoring (MRM) determination under the negative ion mode, and quantifying according to a standard curve and an external standard method, detecting and calculating to obtain the content of 46 residual veterinary drug compositions in animal tissue. The method is applicable to present commonly-used veterinary drugs such as 18 kinds of quinolone drugs, 22 kinds of sulfanilamide drugs, dapsone, phenylethanolamine A, amoxicillin, adamantanamine, rimantadine, ethoxyquin and the like, and is capable of performing one-step simultaneous rapid accurate detection, and the application scope of the method is enlarged.
Owner:INSPECTION & QUARANTINE TECH CENT OF NINGBO ENTRY EXIT INSPECTION & QUARANTINE BUREAU

Method for recycling active ingredients in amoxicillin mother liquor synthesized by enzymatic method

The invention discloses a method for recycling active ingredients in the amoxicillin mother liquor synthesized by an enzymatic method. The method includes synthesizing the amoxicillin mother liquor by the enzymatic method; separating the amoxicillin mother liquor through a macro-porous resin column, eluting the separated amoxicillin mother liquor by deionized water, and collecting an eluant rich in D-4-Hydroxyphenylglycine and an eluant rich in 6-amino penicillanic acid (APA) respectively; filtering the eluant rich in D-4-Hydroxyphenylglycine with Daltonian ultrafiltration membranes with a cutoff molecular weight of 150 to 200; performing nanofiltration concentration on the Daltonian ultrafiltration membranes for the filtered liquor with the cutoff molecular weight of 150 to 200, and standing, crystallizing and filtering the concentrated liquor to obtain solids, and drying the solids to obtain the D-4-Hydroxyphenylglycine. According to the method, the technological design is reasonable, the operation is convenient, the recycling effect is good, and energy is saved and the environment is protected.
Owner:NORTH CHINA PHARM GRP SEMISYNTECH CO LTD

Recovering method of effective components in amoxicillin enzymatic synthesis mother liquor by utilizing nanofiltration

The invention discloses a recovering method of effective components in amoxicillin enzymatic synthesis mother liquor by utilizing nanofiltration. The method comprises the following steps: (1) regulating pH of the mother liquor; (2) hydrolyzing amoxicillin in the mother liquor by utilizing penicillin acylase, thus only D-hydroxyphenylglycine and 6-amino-penicillanic acid (6-amino-penicillanic acid) exist in the other liquor; (3) preparing concentrated mother liquor by nanofiltration; and (4) separating and recovering the D-hydroxyphenylglycine and the 6-amino-penicillanic acid (6-amino-penicillanic acid) by isoelectric point crystallization. The method has the advantages that: the recycling rate of an inactive lateral chain can be improved regarding certain amoxicillin synthetase with highhydrolysis activity, so that the enzymatic synthesis of amoxicillin is more economical.
Owner:INNER MONGOLIA CHANGSHENG PHARMA

Amoxicillin capsules and preparation method thereof

The present invention discloses amoxicillin capsules and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The amoxicillin capsules comprise, by mass, 100 parts of amoxicillin, 0.1-1 part of sodium lauryl sulfate, 0.1-3 parts of talc powder, and 0.25-2.0 parts of magnesium stearate. According to the present invention, the raw material amoxicillin particle size and the proportion of the auxiliary material are adjusted so as to ensure the high amoxicillin dissolution, avoid the use of sodium carboxymethyl starch, cross-linked povidone and other disintegrating agents, and reduce the amoxicillin capsule volume; and the production preparation steps of the amoxicillin capsule drug are simplified, the production cost is reduced, the polymer impurity content in the amoxicillin capsules is reduced, and the production efficiency is improved.
Owner:NORTH CHINA PHARMA COMPANY

Veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and preparation method thereof

The invention discloses a veterinary suspension containing amoxicillin, colistin sulfate and prednisolone and a preparation method thereof. The veterinary suspension adopts the amoxicillin, the colistin sulfate and the prednisolone as active ingredients. The preparation method of the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone comprises the following steps of: (1) dissolving or dispersing a suspending agent, an antioxidant and a preservative in a hot dispersion medium to obtain a solution (A); (2) adding 40-80 percent of dispersion medium in a formula ratio in a colloid mill, starting the colloid mill, then slowly adding the solution (A) and adding a wetting agent while stirring after the solution (A) is fully added; (3) sequentially adding the amoxicillin, the colistin sulfate and the prednisolone after fully adding all the accessories, and grinding by adopting two alternate modes, i.e. an endless grinding mode and a non-endless grinding mode; and (4) detecting the grain fineness, stopping grinding when the grain fineness accords with the requirement, adding the dispersion medium to the formula ratio, mixing, canning, sealing and sterilizing to obtain the veterinary suspension containing the amoxicillin, the colistin sulfate and the prednisolone.
Owner:CHINA AGRI UNIV +1

Penicillin G acylase immobilized with a crosslinked mixture of gelled gelatin and amino polymer

PCT No. PCT / EP96 / 03253 Sec. 371 Date Jan. 15, 1998 Sec. 102(e) Date Jan. 15, 1998 PCT Filed Jul. 16, 1996 PCT Pub. No. WO97 / 04086 PCT Pub. Date Feb. 6, 1997Penicillin G acylase is immobilized by covalent bonding to a crosslinked mixture of a gelled gelling agent such as gelatin and a polymer containing free amino groups such as alginate amine, chitosan or polyethylene imine. The immobilized penicillin G acylase provides a higher synthesis / hydrolysis ratio as compared to immobilizing with other carriers when producing beta -lactam derivatives by a condensing reaction of an amino beta -lactam with an acylating agent. The acylating agent may be a derivative of D-phenylglycine, a derivative of D-p-hydroxyphenylglycine or a derivative of D-2,5-dihydro-phenylglycine. Examples of beta -lactam derivatives that can be produced are amoxycillin, ampicillin, cephaclor, cephadroxil, cephprozil, cephalexin and cephradine.
Owner:GIST BROCADES NV

Amoxicillin preparation and preparation method thereof

The invention relates to an amoxicillin preparation and a preparation method thereof. The amoxicillin preparation comprises 5-50 parts of amoxicillin, 3-38 parts of a stabilizer, 0.2-10 parts of a solubilizer, 0.1-1 part of a complexing agent and 1-91.7 parts of an auxiliary material. The preparation method comprises the following steps: the stabilizer and the solubilizer are ground and sieved by a sieve with 80-120 meshes and fed into a mixing tank according to a formula to be uniformly mixed with amoxicillin; the auxiliary material is ground and sieved by a sieve with 80-100 meshes and fed into the mixing tank according to a formula to be uniformly mixed, and a finished product is obtained through sub-packaging. The amoxicillin preparation has high water solubility and high stability, and according to 6-mouth acceleration test, the content of amoxicillin is in a prescribed range all along; the use requirement of a doser of a large-scale farm is met; an aqueous solution of the amoxicillin preparation is not prone to be influenced by objective factors such as the temperature, metal ions, ph and the like, the content of effective components can keeps unchanged for 24 hours, and the effect of treatment of livestock colibacillosis caused by Gram-negative bacteria is improved substantially.
Owner:QINGDAO KDN BIOTECH +1

Catalyst for photocatalytic degradation of antibiotic as well as preparation method and application thereof

The invention belongs to the field of environmental technology and water treatment and specifically relates to a preparation method of a catalyst for photocatalytic degradation of antibiotic, a catalyst prepared by the method and application of the catalyst for photocatalytic degradation of antibiotic. The catalyst is anatase-phase banded-structure nanocrystal titanium dioxide exposing the crystal face {100}, and is synthesized by a homogeneous hydrothermal reaction and a calcination technology. The catalyst shows outstanding photocatalytic degradation performance on the photocatalytic degradation of broad-spectrum antibiotic medicines such as oxytetracycline, tetracycline hydrochloride, amoxicillin, norfloxacin and enrofloxacin. The catalyst has the characteristics of high activity, stable performance, easiness in separation, no toxicity and the like; the synthesis technology is pollution-free; the catalyst has a broad application prospect while the antibiotic medicine pollution is increasingly severe.
Owner:NAT UNIV OF SINGAPORE +1

Amoxicillin soluble powder as well as preparation method and application thereof

The invention provides an amoxicillin soluble powder as well as a preparation method and application thereof, which can solve the problem in the prior art that amoxicillin has low solubility in water and has big possibility of deteriorating in water. The invention adopts the following technical scheme: the amoxicillin soluble powder comprises the following components in percentage by weight: 1-50 wt% of amoxicillin and 50-99 wt% of polyethylene glycol. The invention also provides the preparation method and application of the amoxicillin soluble powder. With respect to the amoxicillin soluble powder prepared by the invention, the solubility of amoxicillin in water is increased and the stability of amoxicillin in water is improved.
Owner:QINGDAO VLAND BIOTECH INC +1

Technology for preparing amoxicillin by straight-through method

The invention discloses a technology for preparing amoxicillin by a straight-through method. The technology takes a penicillin degreasing fluid as a starting raw material; 6-APA (6-amino penicillanic acid) crystallization, suction filtration, washing and drying steps are saved; the amoxicillin can be prepared without obtaining solid 6-APA via separation; and the prepared amoxicillin meets a requirement of a medicinal standard. The technology saves an operation procedure, reduces the labor intensity of production personnel, lowers the production cost, reduces environmental protection pressure, avoids contact between the production personnel and 6-APA dry powder, and reduces anaphylaxis.
Owner:石药集团中诺药业(石家庄)有限公司

Amoxicillin pharmaceutical preparation and preparation method thereof

The invention discloses an amoxicillin pharmaceutical preparation and a preparation method thereof. The amoxicillin pharmaceutical preparation comprises the following components in parts by mass: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate. The preparation method is a dry-press process. By controlling the particle size distribution of amoxicillin, the particle size distribution of magnesium stearate and the pressure of the dry press, excellent dissolution quantity and stability of the amoxicillin preparation can be ensured.
Owner:GUANGZHOU BAIYUNSHAN PHARMA HLDG CO LTD BAIYUNSHAN PHARMA GENERAL FACTORY

Amoxicillin granule and production method thereof

The invention provides amoxicillin granules and the production method thereof, in particular relates to a method of adopting the micropowder technology to prepare amoxicillin granules. The method is characterized in that the method includes the steps that a superfine pulverizer is used to pulverize amoxicillin to obtain fine powder with the particle size of 25um-50um. The amoxicillin granules prepared by the method have the advantages of good dissolution, good stability, greatly reducing the dosage of auxiliary material, reducing the toxic and side effects, simple preparation process and easy operation.
Owner:HAINAN MEIDA PHARMA

Amoxicillin dispersible tablet and production method thereof

The invention discloses a novel formulation of amoxicillin, and in particular relates to an amoxicillin dispersible tablet and a production method thereof. The production method adopts powder direct compression technology. The amoxicillin dispersible tablet consists of amoxicillin raw medicament and a drug carrier, wherein the drug carrier comprises a diluting agent, a disintegrant and a lubricant, and selectively comprises a sweetening agent and an aromatizer; and the weight ratio of the amoxicillin raw medicament to the drug carrier is 2:1-4:1.
Owner:NORTH CHINA PHARMA COMPANY

Compound capsule and preparation method thereof

The invention relates to a compound capsule and a preparation method thereof. The capsule comprises lansoprazole enteric coated pellets, clarithromycin stomach-soluble pellets and amoxicillin stomach-soluble pellets. The compound capsule is administered twice one day based on the following dose each time: lansoprazole 20-40 mg, clarithromycin 400-600 mg, and amoxicillin 900-1100 mg. The capsule provided by the invention has a distinct effect on peptic ulcer, is used for thoroughly killing helicobacter pylori, and has the advantages of quick action, strong effect, improved bioavailability, convenience in administration and low cost.
Owner:王勇

Method for detecting amoxicillin residual quantity in milk and meat product

The invention discloses a method for detecting amoxicillin residual quantity in milk and meat products. The method includes the following steps: preparing amoxicillin standard aqueous solution; adding a nonionic surfactant; reacting the obtained solution with quinone or alizarin to get a charge transfer system; determining the wavelength scanning range of fluorescence or ultraviolet; further calculating the linear range, working curve and other parameters of the standard solution; processing the sample to be detected by corresponding charge transfer reaction; determining reaction parameters under ultraviolet or fluorescence; and calculating to obtain the amoxicillin residue quantity. The technology further enhances the value of fluorescence intensity or UV absorption by utilizing the sensitizing effect of non-ionic surfactants, thus meets the low-residue testing requirement; simultaneously improves the system stability significantly, makes up the disadvantage of poor detection stability of fluorescence in the earlier application, and is more feasible in the actual detection.
Owner:云南健牛环境监测有限公司

Preparation method and application of high-amoxicillin-content soluble powder

The invention relates to high-amoxicillin-content soluble powder, and a preparation method and application thereof, and belongs to the field of a veterinary drug. The problem that an amoxicillin aqueous solution is low in dissolvability and poor in stability, which affects a therapeutic effect and application of the amoxicillin aqueous solution is solved. The powder comprises amoxicillin, a co-solvent, a stabilizing agent, a corrigent, and a soluble filler, and is used for treating porcine intestinal and respiratory tract infection due to bacteria such as escherichia coli and salmonella.
Owner:RINGPU TIANJIN BIOLOGICAL PHARMA

Breast perfusion preparation for treating mammitis of milk cow in lactation period and preparation method thereof

The invention provides a breast perfusion preparation for treating mammitis of milk cow in lactation period, which belongs to the field of medical preparation for veterinary use; every 3g of the perfusion preparation contains 150-250 mg of amoxicillin, 50-125 mg of sulbactam, 5-15 mg of prednisolone and the rest of substrate; the substrate contains 0.1-12% of suspending aid, 0.1-2% of wetting agent, 0.01-1% of antioxidant, 0.05-1% of preservative and the rest of dispersion medium; the invention can be obtained via the following steps: firstly, dissolving or dispersing suspending aid, antioxidant, wetting agent and preservative into proper amount of dispersion medium, then slowly adding the rest of the dispersion medium into a colloid mill to obtain the substrate, adding medicine into the substrate, grinding via the alternating method of circularly grinding and non-circularly grinding. The preparation of the invention is simple in preparation technique, easy to realize industrialization, low in production cost, low in expenditure for treatment, low in toxicity, wide to use and high in efficiency; the invention can be clinically used for treating mammitis in lactation period caused by Gram positive bacterium and Gram negative bacterium.
Owner:CHINA AGRI UNIV

Suspensoid powder injection of amoxicillin sodium sulbactam sodium medicine composition and novel application thereof

The invention relates to suspensoid powder injection of an amoxicillin sodium sulbactam sodium medicine composition and a preparation method thereof. The suspensoid powder injection contains Tween 80, cholesterol, deoxysodium cholate, a freeze-drying support agent and active components. The invention also relates to a novel application of the suspensoid powder injection in preparing a medicine treating prostatitis further.
Owner:HAINAN YONGTIAN PHARMA INST

A kind of preparation method of amoxicillin sodium

The present invention relates to the field of drug synthesis, in particular to a method for preparing amoxicillin sodium. The method of the present invention comprises the following steps: (1) preparation of acid anhydride; (2) preparation of 6-APA solution; (3) condensation: Move the 6-APA salt solution into the mixed acid anhydride reaction bottle, and time it for 3 hours; (4) Hydrolysis: add the condensation solution of step (3) to the hydrolyzed solution; (5) Crystallization: Leave the crystal to grow for 1 hour and then stir to grow the crystal for 1 hour (6) Suction drying: wash with water first, then wash with acetone, and dry in vacuum at 40° C. for 3 hours to obtain amoxicillin.
Owner:HARBIN PHARMA GRP CO LTD GENERAL PHARMA FACTORY

Improved method for preparing amoxicillin by enzymic method

The invention relates to the field of pharmacy, and provides an improved method for preparing amoxicillin by an enzymic method, and a product obtained by the improved method for preparing amoxicillin by the enzymic method. The method comprises the following steps of: 1) dissolving 6-aminopenicillanic acid (6-APA) at the temperature of between 10 and 20 DEG C by using water or / and aqueous solution of ammonia which has the pH value of 7.0 to 8.0, and adding D-p-Hydroxyphenylglycine methyl ester hydrochlorid and penicillin G acyltransferase; 2) adjusting the pH value of a solution obtained in the step 1) to be 6.0 to 6.5, and reacting at the temperature of between 21 and 30 DEG C until the content of 6-APA is less than 5mg / ml to obtain a solution of an amoxicillin product; and 3) separating the penicillin G acyltransferase from the solution of the amoxicillin product, adjusting by using hydrochloric acid until the solution of the amoxicillin product is clarified, adding the aqueous solution of ammonia, adjusting the pH value to be 5.5 to 6.5, and crystallizing at the temperature of between 0 and 5 DEG C to obtain amoxicillin. By the improved method for preparing amoxicillin by the enzymic method, the quality of the amoxicillin product is greatly improved, and the medication safety of the amoxicillin product is further improved.
Owner:UNITED LAB INNER MONGOLIA CO LTD

Medication for preventing and treating diseases of pigs

A veterinary medicine for preventing and treating the frequently encountered diseases of pig, such as metritis, mammitis, acyesis, sterility, dysentery, epidemic enteritis, paratyphoid, asthma, etc is prepared from 15 raw materials including florfenicol, amoxicillin, lucomycin, doxycycline, etc.
Owner:杨联华

Method for simultaneously detecting 15 antibiotics in aquaculture sediment by combining microwave extraction-solid phase extraction pretreatment with liquid chromatography-mass spectrometry technology

The invention relates to a method for simultaneously detecting 15 antibiotics in aquaculture sediment by combining microwave extraction-solid phase extraction pretreatment with a liquid chromatography-mass spectrometry (LC-MS) technology. The method comprises the following steps: step (1) pretreating sediment samples, adding internal standard substances sulfamethoxazole-13C6, norfloxacin-D5, penicillin G potassium salt-D5, tetracycline-D6, olaquindox-D4, amoxicillin-13C6 and trimethoprim-D3 indicating a recovery rate, adding an acetonitrile-phosphate buffer solution for microwave extraction ofextraction liquid; step (2) performing solid phase extraction, enrichment and purification on target antibiotics; and step (3) quantitatively detecting 15 antibiotics of seven types in sediment witha liquid chromatograph / mass spectrometer. The method can simultaneously detect residues of 15 antibiotics containing 8 new antibiotics in the aquaculture sediment at a time by optimizing the internalstandard substances, screening appropriate pretreatment method and optimizing detection conditions, and has the advantages of high recovery rate, high sensitivity, high stability, low detection limit,more true and reliable detection results and the like.
Owner:SHANGHAI ACADEMY OF ENVIRONMENTAL SCIENCES

Preparation method of hollow porous microsphere adsorbent

The invention discloses a preparation method of a hollow porous microsphere adsorbent and belongs to the technical field of environment-friendly functional material preparation. ZIF-8 nanoparticles are used as stable particles of a Pickering emulsion and are dispersed into a solution so as to be used as a water phase. Dodecane is used as an oil-phase solvent, and crosslinking agents azodiisobutyronitrile, styrene and vinyl benzene are mixed to be used as an oil phase. The water phase and the oil phase are mixed to form a stable Pickering emulsion. The hollow porous microsphere adsorbent is prepared by carrying out a thermal initiation reaction and is applied to the adsorption and separation of amoxicillin in a water solution. The product has large specific surface area and good stability and is beneficial to the adsorption of target molecules, porous ZIF-8 attached to the outer parts of the hollow microspheres provides a great number adsorption sites for the material, and the ZIF-8 nanoparticles stably attached to the hollow microspheres are more conveniently recycled as comparison with ZIF-8 particles in discrete distribution.
Owner:CHANGZHOU UNIV

Amoxicillin capsule and production method thereof

The invention relates to an amoxicillin capsule and the preparation method thereof, in particular to a method of adopting the micropowder technology to prepare amoxicillin capsules. The method utilizes the micropowder technology to overcome the bad dissolution of the amoxicillin capsule in the prior art; meanwhile, the amoxicillin capsule prepared by the method has the advantages of improving the preparation stability, simplifying the preparation process, reducing the toxic and side effects.
Owner:HAINAN MEIDA PHARMA

Compound enrofloxacin pellets and preparation method thereof

The invention relates to compound enrofloxacin pellets and a preparation method of the compound enrofloxacin pellets, wherein the enrofloxacin pellets comprise coatings and medicine-carrying pill cores; the coatings wrap the medicine-carrying pill cores; the medicine-carrying pill cores are prepared by the following steps that: amoxicillin and enrofloxacin are mixed with starch, microcrystalline cellulose, carboxymethyl starch and the like uniformly; an appropriate amount of pelleting adhesive is added in the mixture to prepare the soft material, the soft material is added into an extrusion pelleter to be extruded out, the extruded material is placed in a shot blasting machine to prepare the medicine-carrying pill cores. Then, the pill cores are placed into a fluidized bed to be dried andthen sieved; finally the sieved pill cores are placed into the fluidized bed, coating liquid is injected for coating, fluidized drying is then carried out after the coating, and then the finished product is obtained. According to the invention, both the amoxicillin and enrofloxacin are used, so that double effects are achieved, the medicine administration frequency and dose are reduced, and the pellets are easy to take only by stirring, and feed intake of animals is not influenced. In addition, the preparation method of the compound enrofloxacin pellets has simple process steps and low energyconsumption, is safe to produce and easy to implement, and the prepared pellets have uniform granularity.
Owner:GUANGDONG WENS DAHUANONG BIOTECH

Method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by enzyme process

The invention relates to a method for comprehensively recovering effective ingredients in amoxicillin mother liquid prepared by an enzyme process. The method comprises the following steps: (1) concentrating the amoxicillin mother liquid, namely adjusting the pH value of the amoxicillin mother liquid prepared by the enzyme process to be 8.0-9.5, and performing nanofiltration and concentration to obtain concentrated mother liquid; (2) synthesizing amoxicillin under enzyme catalysis, namely adjusting the pH value of the concentrated mother liquid to be 5.8-7.0, and converting 6-APA (6-amino penicillanic acid) and D-methyl hydroxyphenyl glycinate into amoxicillin in the presence of immobilized penicillin acylase for synthesis; (3) preparing D-hydroxyphenyl glycine concentrated liquid by ultrafiltration and nanofiltration, namely separating after the enzyme catalysis reaction is ended to obtain amoxicillin crystals and secondary amoxicillin mother liquid, and performing ultrafiltration and nanofiltration on the secondary mother liquid to obtain the D-hydroxyphenyl glycine concentrated liquid; (4) crystallizing D-hydroxyphenyl glycine. According to the method, 6-APA and D-methyl hydroxyphenyl glycinate remained in the mother liquid are consumed through an indirect process of synthesizing amoxicillin under enzyme catalysis, the product quality of D-hydroxyphenyl glycine is improved, and the yield of D-hydroxyphenyl glycine is increased.
Owner:SHANXI WEIQIDA PHARMA IND

Amoxicillin colistin sulphate granule and preparation method thereof

The invention discloses an amoxicillin colistin sulphate granule and a preparation method thereof. The amoxicillin colistin sulphate granule comprises the following ingredients in parts by weight: 1-25 parts of amoxicillin, 0.5-50 parts of colistin sulphate and 50-90 parts of additives, as well as an adhesive accounting for 0.5-8 parts of the weight sum of the ingredients, and the amoxicillin colistin sulphate granule is prepared by such steps as sieving, dissolving, mixing, drying and pelletizing. The amoxicillin and colistin sulphate in the invention can be uniformly mixed, thereby improving the solubility of the product in water, reinforcing the efficacy, ensuring the treatment effect, facilitating the quick recovery of animals, guaranteeing easy storage and low by-effect and reinforcing the treatment effect by drug combination; the amoxicillin colistin sulphate granule can be not only used for treating mixed infection of pigs, but also being conveniently applied on clinic and facilitating the prevention and treatment of group animal diseases so as to alleviate animal stress reactions and reduce the labor intensity of manual drug use.
Owner:GUANGDONG WENS DAHUANONG BIOTECH

Amoxicillin soluble powder and preparation method thereof

The invention relates to amoxicillin soluble powder and a preparation method thereof. The amoxicillin soluble powder is composed of the following components, by weight: 10-60 parts of amoxicillin trihydrate, 3-20 parts of a cosolvent, 3-30 parts of a stabilizer, 0.4-85 parts of a filler, and 0.05-1 part of a glidant, wherein the stabilizer is sodium hexametaphosphate. The preparation method comprises: micronizing the raw material, amoxicillin trihydrate, crushing and screening the cosolvent, the stabilizer, the filler and the glidant respectively, mixing materials, subpackaging, and checking to obtain the finished amoxicillin soluble powder. The amoxicillin soluble powder is high in solubility and good in stability, can inhibit hydrolysis of drugs and is beneficial to practical application.
Owner:CHINANIMAL NANJING VETERINARY DRUGS

Amoxicillin antibacterial agent containing nano silver, and its preparing method and use

InactiveCN1850113ASmall doseExcellent synergistic antibacterial effectAntibacterial agentsPowder deliveryAmoxicillinNanotechnology
The present invention relates to an amoxicillin antimicrobial containing nano silver. its preparation method and application. At the normal temperature the nano silver and amoxicillin are uniformly mixed so as to obtain the invented amoxicillin antimicrobial containing nano silver. The tests show that said invention has stronger antimicrobial effect.
Owner:TONGJI UNIV

Method for simultaneously detecting residual amoxicillin, amoxicillin acid, diketopiperazine amoxicillin and ampicillin in egg

The invention belongs to the field of veterinary drug residue detection, in particular relating to a method for simultaneously detecting residual amoxicillin (AMO), amoxicillin acid (AMA), diketopiperazine amoxicillin (DIKETO) and ampicillin (AMP) in an egg. The method comprises the steps of extracting and purifying egg samples, and detecting the egg samples by taking acetonitrile-0.1% formic acid as a mobile phase by adopting a high performance liquid chromatography-tandem mass spectrometry method. Through the method for simultaneously detecting the residual amoxicillin, amoxicillin acid, diketopiperazine amoxicillin and ampicillin in the egg as disclosed by the invention, the residue of the amoxicillin, the amoxicillin acid, the diketopiperazine amoxicillin and the ampicillin in the egg can be simultaneously detected, and the invention meets with the European Union standard.
Owner:YANGZHOU UNIV
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