592 results about "Amoxicillin" patented technology

A disclosed method for simultaneously analyzing and detecting residual veterinary drug compositions in animal tissue comprises: performing homogenate on an animal tissue sample by 50% acetonitrile and ethanol, performing ultrasonic extraction and hexane purifying, and performing further precipitation by acetonitrile and ethanol, concentrating, utilizing UPLC-MS/MS to perform multi-reaction monitoring (MRM) determination under the negative ion mode, and quantifying according to a standard curve and an external standard method, detecting and calculating to obtain the content of 46 residual veterinary drug compositions in animal tissue. The method is applicable to present commonly-used veterinary drugs such as 18 kinds of quinolone drugs, 22 kinds of sulfanilamide drugs, dapsone, phenylethanolamine A, amoxicillin, adamantanamine, rimantadine, ethoxyquin and the like, and is capable of performing one-step simultaneous rapid accurate detection, and the application scope of the method is enlarged.

The invention discloses a method for recycling active ingredients in the amoxicillin mother liquor synthesized by an enzymatic method. The method includes synthesizing the amoxicillin mother liquor by the enzymatic method; separating the amoxicillin mother liquor through a macro-porous resin column, eluting the separated amoxicillin mother liquor by deionized water, and collecting an eluant rich in D-4-Hydroxyphenylglycine and an eluant rich in 6-amino penicillanic acid (APA) respectively; filtering the eluant rich in D-4-Hydroxyphenylglycine with Daltonian ultrafiltration membranes with a cutoff molecular weight of 150 to 200; performing nanofiltration concentration on the Daltonian ultrafiltration membranes for the filtered liquor with the cutoff molecular weight of 150 to 200, and standing, crystallizing and filtering the concentrated liquor to obtain solids, and drying the solids to obtain the D-4-Hydroxyphenylglycine. According to the method, the technological design is reasonable, the operation is convenient, the recycling effect is good, and energy is saved and the environment is protected.

The invention discloses a recovering method of effective components in amoxicillin enzymatic synthesis mother liquor by utilizing nanofiltration. The method comprises the following steps: (1) regulating pH of the mother liquor; (2) hydrolyzing amoxicillin in the mother liquor by utilizing penicillin acylase, thus only D-hydroxyphenylglycine and 6-amino-penicillanic acid (6-amino-penicillanic acid) exist in the other liquor; (3) preparing concentrated mother liquor by nanofiltration; and (4) separating and recovering the D-hydroxyphenylglycine and the 6-amino-penicillanic acid (6-amino-penicillanic acid) by isoelectric point crystallization. The method has the advantages that: the recycling rate of an inactive lateral chain can be improved regarding certain amoxicillin synthetase with highhydrolysis activity, so that the enzymatic synthesis of amoxicillin is more economical.

The present invention discloses amoxicillin capsules and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The amoxicillin capsules comprise, by mass, 100 parts of amoxicillin, 0.1-1 part of sodium lauryl sulfate, 0.1-3 parts of talc powder, and 0.25-2.0 parts of magnesium stearate. According to the present invention, the raw material amoxicillin particle size and the proportion of the auxiliary material are adjusted so as to ensure the high amoxicillin dissolution, avoid the use of sodium carboxymethyl starch, cross-linked povidone and other disintegrating agents, and reduce the amoxicillin capsule volume; and the production preparation steps of the amoxicillin capsule drug are simplified, the production cost is reduced, the polymer impurity content in the amoxicillin capsules is reduced, and the production efficiency is improved.

The invention belongs to the field of environmental technology and water treatment and specifically relates to a preparation method of a catalyst for photocatalytic degradation of antibiotic, a catalyst prepared by the method and application of the catalyst for photocatalytic degradation of antibiotic. The catalyst is anatase-phase banded-structure nanocrystal titanium dioxide exposing the crystal face {100}, and is synthesized by a homogeneous hydrothermal reaction and a calcination technology. The catalyst shows outstanding photocatalytic degradation performance on the photocatalytic degradation of broad-spectrum antibiotic medicines such as oxytetracycline, tetracycline hydrochloride, amoxicillin, norfloxacin and enrofloxacin. The catalyst has the characteristics of high activity, stable performance, easiness in separation, no toxicity and the like; the synthesis technology is pollution-free; the catalyst has a broad application prospect while the antibiotic medicine pollution is increasingly severe.

The invention provides an amoxicillin soluble powder as well as a preparation method and application thereof, which can solve the problem in the prior art that amoxicillin has low solubility in water and has big possibility of deteriorating in water. The invention adopts the following technical scheme: the amoxicillin soluble powder comprises the following components in percentage by weight: 1-50 wt% of amoxicillin and 50-99 wt% of polyethylene glycol. The invention also provides the preparation method and application of the amoxicillin soluble powder. With respect to the amoxicillin soluble powder prepared by the invention, the solubility of amoxicillin in water is increased and the stability of amoxicillin in water is improved.

The invention discloses an amoxicillin pharmaceutical preparation and a preparation method thereof. The amoxicillin pharmaceutical preparation comprises the following components in parts by mass: 90.0-99.9 parts of amoxicillin and 0.1-10.0 parts of magnesium stearate. The preparation method is a dry-press process. By controlling the particle size distribution of amoxicillin, the particle size distribution of magnesium stearate and the pressure of the dry press, excellent dissolution quantity and stability of the amoxicillin preparation can be ensured.

The invention discloses a novel formulation of amoxicillin, and in particular relates to an amoxicillin dispersible tablet and a production method thereof. The production method adopts powder direct compression technology. The amoxicillin dispersible tablet consists of amoxicillin raw medicament and a drug carrier, wherein the drug carrier comprises a diluting agent, a disintegrant and a lubricant, and selectively comprises a sweetening agent and an aromatizer; and the weight ratio of the amoxicillin raw medicament to the drug carrier is 2:1-4:1.

The invention discloses a method for detecting amoxicillin residual quantity in milk and meat products. The method includes the following steps: preparing amoxicillin standard aqueous solution; adding a nonionic surfactant; reacting the obtained solution with quinone or alizarin to get a charge transfer system; determining the wavelength scanning range of fluorescence or ultraviolet; further calculating the linear range, working curve and other parameters of the standard solution; processing the sample to be detected by corresponding charge transfer reaction; determining reaction parameters under ultraviolet or fluorescence; and calculating to obtain the amoxicillin residue quantity. The technology further enhances the value of fluorescence intensity or UV absorption by utilizing the sensitizing effect of non-ionic surfactants, thus meets the low-residue testing requirement; simultaneously improves the system stability significantly, makes up the disadvantage of poor detection stability of fluorescence in the earlier application, and is more feasible in the actual detection.

The invention relates to high-amoxicillin-content soluble powder, and a preparation method and application thereof, and belongs to the field of a veterinary drug. The problem that an amoxicillin aqueous solution is low in dissolvability and poor in stability, which affects a therapeutic effect and application of the amoxicillin aqueous solution is solved. The powder comprises amoxicillin, a co-solvent, a stabilizing agent, a corrigent, and a soluble filler, and is used for treating porcine intestinal and respiratory tract infection due to bacteria such as escherichia coli and salmonella.

The invention provides a breast perfusion preparation for treating mammitis of milk cow in lactation period, which belongs to the field of medical preparation for veterinary use; every 3g of the perfusion preparation contains 150-250 mg of amoxicillin, 50-125 mg of sulbactam, 5-15 mg of prednisolone and the rest of substrate; the substrate contains 0.1-12% of suspending aid, 0.1-2% of wetting agent, 0.01-1% of antioxidant, 0.05-1% of preservative and the rest of dispersion medium; the invention can be obtained via the following steps: firstly, dissolving or dispersing suspending aid, antioxidant, wetting agent and preservative into proper amount of dispersion medium, then slowly adding the rest of the dispersion medium into a colloid mill to obtain the substrate, adding medicine into the substrate, grinding via the alternating method of circularly grinding and non-circularly grinding. The preparation of the invention is simple in preparation technique, easy to realize industrialization, low in production cost, low in expenditure for treatment, low in toxicity, wide to use and high in efficiency; the invention can be clinically used for treating mammitis in lactation period caused by Gram positive bacterium and Gram negative bacterium.

The invention relates to suspensoid powder injection of an amoxicillin sodium sulbactam sodium medicine composition and a preparation method thereof. The suspensoid powder injection contains Tween 80, cholesterol, deoxysodium cholate, a freeze-drying support agent and active components. The invention also relates to a novel application of the suspensoid powder injection in preparing a medicine treating prostatitis further.

The invention relates to the field of pharmacy, and provides an improved method for preparing amoxicillin by an enzymic method, and a product obtained by the improved method for preparing amoxicillin by the enzymic method. The method comprises the following steps of: 1) dissolving 6-aminopenicillanic acid (6-APA) at the temperature of between 10 and 20 DEG C by using water or/and aqueous solution of ammonia which has the pH value of 7.0 to 8.0, and adding D-p-Hydroxyphenylglycine methyl ester hydrochlorid and penicillin G acyltransferase; 2) adjusting the pH value of a solution obtained in the step 1) to be 6.0 to 6.5, and reacting at the temperature of between 21 and 30 DEG C until the content of 6-APA is less than 5mg/ml to obtain a solution of an amoxicillin product; and 3) separating the penicillin G acyltransferase from the solution of the amoxicillin product, adjusting by using hydrochloric acid until the solution of the amoxicillin product is clarified, adding the aqueous solution of ammonia, adjusting the pH value to be 5.5 to 6.5, and crystallizing at the temperature of between 0 and 5 DEG C to obtain amoxicillin. By the improved method for preparing amoxicillin by the enzymic method, the quality of the amoxicillin product is greatly improved, and the medication safety of the amoxicillin product is further improved.

A veterinary medicine for preventing and treating the frequently encountered diseases of pig, such as metritis, mammitis, acyesis, sterility, dysentery, epidemic enteritis, paratyphoid, asthma, etc is prepared from 15 raw materials including florfenicol, amoxicillin, lucomycin, doxycycline, etc.

The invention relates to a method for simultaneously detecting 15 antibiotics in aquaculture sediment by combining microwave extraction-solid phase extraction pretreatment with a liquid chromatography-mass spectrometry (LC-MS) technology. The method comprises the following steps: step (1) pretreating sediment samples, adding internal standard substances sulfamethoxazole-13C6, norfloxacin-D5, penicillin G potassium salt-D5, tetracycline-D6, olaquindox-D4, amoxicillin-13C6 and trimethoprim-D3 indicating a recovery rate, adding an acetonitrile-phosphate buffer solution for microwave extraction ofextraction liquid; step (2) performing solid phase extraction, enrichment and purification on target antibiotics; and step (3) quantitatively detecting 15 antibiotics of seven types in sediment witha liquid chromatograph/mass spectrometer. The method can simultaneously detect residues of 15 antibiotics containing 8 new antibiotics in the aquaculture sediment at a time by optimizing the internalstandard substances, screening appropriate pretreatment method and optimizing detection conditions, and has the advantages of high recovery rate, high sensitivity, high stability, low detection limit,more true and reliable detection results and the like.

The invention discloses a preparation method of a hollow porous microsphere adsorbent and belongs to the technical field of environment-friendly functional material preparation. ZIF-8 nanoparticles are used as stable particles of a Pickering emulsion and are dispersed into a solution so as to be used as a water phase. Dodecane is used as an oil-phase solvent, and crosslinking agents azodiisobutyronitrile, styrene and vinyl benzene are mixed to be used as an oil phase. The water phase and the oil phase are mixed to form a stable Pickering emulsion. The hollow porous microsphere adsorbent is prepared by carrying out a thermal initiation reaction and is applied to the adsorption and separation of amoxicillin in a water solution. The product has large specific surface area and good stability and is beneficial to the adsorption of target molecules, porous ZIF-8 attached to the outer parts of the hollow microspheres provides a great number adsorption sites for the material, and the ZIF-8 nanoparticles stably attached to the hollow microspheres are more conveniently recycled as comparison with ZIF-8 particles in discrete distribution.

The invention relates to an amoxicillin capsule and the preparation method thereof, in particular to a method of adopting the micropowder technology to prepare amoxicillin capsules. The method utilizes the micropowder technology to overcome the bad dissolution of the amoxicillin capsule in the prior art; meanwhile, the amoxicillin capsule prepared by the method has the advantages of improving the preparation stability, simplifying the preparation process, reducing the toxic and side effects.

The invention relates to compound enrofloxacin pellets and a preparation method of the compound enrofloxacin pellets, wherein the enrofloxacin pellets comprise coatings and medicine-carrying pill cores; the coatings wrap the medicine-carrying pill cores; the medicine-carrying pill cores are prepared by the following steps that: amoxicillin and enrofloxacin are mixed with starch, microcrystalline cellulose, carboxymethyl starch and the like uniformly; an appropriate amount of pelleting adhesive is added in the mixture to prepare the soft material, the soft material is added into an extrusion pelleter to be extruded out, the extruded material is placed in a shot blasting machine to prepare the medicine-carrying pill cores. Then, the pill cores are placed into a fluidized bed to be dried andthen sieved; finally the sieved pill cores are placed into the fluidized bed, coating liquid is injected for coating, fluidized drying is then carried out after the coating, and then the finished product is obtained. According to the invention, both the amoxicillin and enrofloxacin are used, so that double effects are achieved, the medicine administration frequency and dose are reduced, and the pellets are easy to take only by stirring, and feed intake of animals is not influenced. In addition, the preparation method of the compound enrofloxacin pellets has simple process steps and low energyconsumption, is safe to produce and easy to implement, and the prepared pellets have uniform granularity.

The invention discloses an amoxicillin colistin sulphate granule and a preparation method thereof. The amoxicillin colistin sulphate granule comprises the following ingredients in parts by weight: 1-25 parts of amoxicillin, 0.5-50 parts of colistin sulphate and 50-90 parts of additives, as well as an adhesive accounting for 0.5-8 parts of the weight sum of the ingredients, and the amoxicillin colistin sulphate granule is prepared by such steps as sieving, dissolving, mixing, drying and pelletizing. The amoxicillin and colistin sulphate in the invention can be uniformly mixed, thereby improving the solubility of the product in water, reinforcing the efficacy, ensuring the treatment effect, facilitating the quick recovery of animals, guaranteeing easy storage and low by-effect and reinforcing the treatment effect by drug combination; the amoxicillin colistin sulphate granule can be not only used for treating mixed infection of pigs, but also being conveniently applied on clinic and facilitating the prevention and treatment of group animal diseases so as to alleviate animal stress reactions and reduce the labor intensity of manual drug use.

The invention relates to amoxicillin soluble powder and a preparation method thereof. The amoxicillin soluble powder is composed of the following components, by weight: 10-60 parts of amoxicillin trihydrate, 3-20 parts of a cosolvent, 3-30 parts of a stabilizer, 0.4-85 parts of a filler, and 0.05-1 part of a glidant, wherein the stabilizer is sodium hexametaphosphate. The preparation method comprises: micronizing the raw material, amoxicillin trihydrate, crushing and screening the cosolvent, the stabilizer, the filler and the glidant respectively, mixing materials, subpackaging, and checking to obtain the finished amoxicillin soluble powder. The amoxicillin soluble powder is high in solubility and good in stability, can inhibit hydrolysis of drugs and is beneficial to practical application.

The invention provides a preparation method of D-para hydroxybenzene glycine methyl ester. The method comprises the following steps of: firstly, preparing a hydrochloric acid methanol solution; adding D-para hydroxybenzene glycine into the hydrochloric acid methanol solution to perform reflux reaction for 2-4 hours at 65-80 DEG C; performing pressure reduction distillation and removing methanol; and adding water to obtain a D-para hydroxybenzene glycine methyl ester aqueous solution. Based on that, the invention also provides anenzymatic synthesis method of amoxicillin. The method comprises the following steps of: adding 6-APA and immobilized penicillin acylase into the D-para hydroxybenzene glycine methyl ester aqueous solution to react for 1-8 hours at 10-30 DEG C; regulating the pH value of a reaction liquid to 0.8-1.0 by using hydrochloric acid or sulfuric acid aqueous solution; regulating the pH value to 4.5-6.0 by using ammonia water or sodium hydroxide aqueous solution to crystallize for 1-5 hours at 0-30 DEG C; separating solid from liquid; collecting a solid; and washing and drying to obtain amoxicillin. The method is simple in steps, and low in cost; and the obtained -para hydroxybenzene glycine methyl ester is high in yield and less in impurities and can be directly applied to anenzymatic synthesis of amoxicillin.