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4167results about "Testing medicinal preparations" patented technology
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Target analyte sensors utilizing microspheres
A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ability to identify the location of bioactive agents and particles within the array using an optically interrogatable, optical signature encoding scheme. A wide variety of modified substrates may be employed which provide either discrete or non-discrete sites for accommodating the microspheres in either random or patterned distributions. The substrates may be constructed from a variety of materials to form either two-dimensional or three-dimensional configurations. In a preferred embodiment, a modified fiber optic bundle or array is employed as a substrate to produce a high density array. The disclosed system and method have utility for detecting target analytes and screening large libraries of bioactive agents.
Owner:TRUSTEES OF TUFTS COLLEGETHE
Method to screen phage display libraries with different ligands
InactiveUS6846634B1Overcome inherent biasGuaranteed effective sizePeptide librariesLibrary screeningBinding siteBacteriophage
Owner:DORMANTIS LTD
Biodegradable poly(β-amino esters) and uses thereof
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer / polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings.
Owner:MASSACHUSETTS INST OF TECH
Cell flow apparatus and method for real-time of cellular responses
InactiveUS6280967B1Quick filterIncrease the number ofBioreactor/fermenter combinationsCompound screeningMeasurement testCell type
An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds (303) on a flowing suspension of cells (349), in which a homogeneous suspension of each member of a series of cell types (349) is combined with a concentration of a test compound (303), directed through a detection zone (355), and a cellular response of the living cells is measured in real time as the cells in the test mixture are flowing through the detection zone (355). The apparatus may be used in automated screening of libraries of compounds, and is capable of real-time variation of concentrations of test and standard compounds and generation of dose / response profiles within a short time span.
Owner:CAPLIPER LIFE SCI INC
Uses and compositions for treatment of rheumatoid arthritis
ActiveUS20080166348A1Relieve symptomsInhibit progressSsRNA viruses negative-senseBiocideAntigen bindingRheumatoid arthritis
The invention provides methods, uses and compositions for the treatment of rheumatoid arthritis. The invention describes methods and uses for treating rheumatoid arthritis wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment of rheumatoid arthritis in a subject.
Owner:ABBVIE BIOTECHNOLOGY LTD
Abeta 42 lowering agents
InactiveUS20020128319A1Prevent and delay and reverse progressionLower Level RequirementsCompounds screening/testingCompound screeningRegimenCholinesterase inhibition
The invention provides a method of preventing, delaying, or reversing the progression of Alzheimer's disease by administering an A.beta..sub.42 lowering agent to a mammal under conditions in which levels of A.beta..sub.42 are selectively reduced, levels of A.beta..sub.38 are increased, and levels of A.beta..sub.40 are unchanged. The invention provides methods and materials for developing and identifying A.beta..sub.42 lowering agents. In addition, the invention provides methods for identifying agents that increase the risk of developing, or hasten progression of, Alzheimer's disease. The invention also provides compositions of A.beta..sub.42 lowering agents and antioxidants, A.beta..sub.42 lowering agents and non-selective secretase inhibitors, as well as A.beta..sub.42 lowering agents and acetylcholinesterase inhibitors. The invention also provides kits containing A.beta..sub.42 lowering agents, antioxidants, non-selective secretase inhibitors, and / or acetylcholinesterase inhibitors as well as instructions related to dose regimens for A.beta..sub.42 lowering agents, antioxidants, non-selective secretase inhibitors, and acetylcholinesterase inhibitors.
Owner:RGT UNIV OF CALIFORNIA
Systems and methods for monitoring behavior informatics
InactiveUS20030100998A2Improve statistics performanceExpand selectionDrug and medicationsBiostatisticsMulti dimensionalOrganism
Abstract of Disclosure A system and method used to assess animal behavior includes a module having sensors that collects a variety of physical and biological data from a test subject. Interpretation of the data is provided to assess the test subject's behavior, neurology, biochemistry and physiology. The module is useful in observing the effects of a drug on the test animal and providing information on the drug's signature. Another advantage is module's portability that allows it to be used in standard laboratory cages. This portability allows the animal to be tested in its own habitat, that can reduce any erroneous data due to stressing the animal when removed to a test cage. Additionally, the module's design allows for parallel data collection and interpretation from several laboratory animals undergoing different experiments. Multi-dimensional modeling of the test subject based the system's interpretation of the data allows pattern recognition of the drug signature, and predictive drug analysis.
Owner:CARNEGIE MELLON UNIV +1
Method to screen phage display libraries with different ligands
InactiveUS20040038291A2Immunoglobulin superfamilyLibrary screeningPolyphageImmunoglobulin superfamily
Abstract of the Disclosure The present invention relates to methods for selecting repertoires of polypeptides using generic and target ligands. In particular, the invention relates to a library comprising a repertoire of polypeptides of the immunoglobulin superfamily, wherein the members of the repertoire have a known main chain conformation.
Owner:DORMANTIS LTD
Single cell gene expression for diagnosis, prognosis and identification of drug targets
InactiveUS20100255471A1Microbiological testing/measurementDisease diagnosisDrug targetDisease status
Methods are provided for diagnosis and prognosis of disease by analyzing expression of a set of genes obtained from single cell analysis. Classification allows optimization of treatment, and determination of whether on whether to proceed with a specific therapy, and how to optimize dose, choice of treatment, and the like. Single cell analysis also provides for the identification and development of therapies which target mutations and / or pathways in disease-state cells.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV
Factor
InactiveUS20100317109A1Administration of has been hamperedEnable neurite outgrowthNervous disorderPeptide/protein ingredientsAgonistNeurite
Owner:MADEN MALCOLM +1
Factor
InactiveUS20070054961A1Administration of has been hamperedNeurite outgrowthBiocideNervous disorderAgonistNeurite growth
Owner:MADEN MALCOLM +1
Anti-mesothelin antibodies having high binding affinity
InactiveUS7081518B1Peptide/protein ingredientsHybrid cell preparationAnti-Mesothelin AntibodyAntiendomysial antibodies
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Owner:UNITED STATES OF AMERICA
Biodegradable poly(beta-amino esters) and uses thereof
InactiveUS7427394B2High molecular weightHigh transfection efficiencyAntibacterial agentsOrganic active ingredientsAmino estersNucleotide
Poly(β-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer / polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
Owner:MASSACHUSETTS INST OF TECH
Methods and products for enhancing immune responses using imidazoquinoline compounds
InactiveUS20060188913A1Good curative effectReduce doseCompound screeningApoptosis detectionTime scheduleDisease
The invention involves administration of an imidazoquinoline agent in combination with another therapeutic agent. The combination of drugs may be administered in synergistic amounts or in various dosages or at various time schedules. The invention also relates to kits and compositions concerning the combination of drugs. The combinations can be used to enhance ADCC, stimulate immune responses and / or patient and treat certain disorders.
Owner:COLEY PHARM GRP INC +2
Methods for drug discovery, disease treatment, and diagnosis using metabolomics
InactiveUS7005255B2Speed up the processNervous disorderMetabolism disorderDiseaseSmall Molecule Libraries
The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for predicting the efficacy of drugs are also discussed.
Owner:CORNELL RES FOUNDATION INC +1
Methods for drug target screening
InactiveUS6165709AMicrobiological testing/measurementRecombinant DNA-technologyProtein targetProtein activity
The present invention provides methods for identifying targets of a drug in a cell by comparing (i) the effects of the drug on a wild-type cell, (ii) the effects on a wild-type cell of modifications to a putative target of the drug, and (iii) the effects of the drug on a wild-type cell which has had the putative target modified of the drug. In various embodiments, the effects on the cell can be determined by measuring gene expression, protein abundances, protein activities, or a combination of such measurements. In various embodiments, modifications to a putative target in the cell can be made by modifications to the genes encoding the target, modification to abundances of RNAs encoding the target, modifications to abundances of target proteins, or modifications to activities of the target proteins. The present invention also provides methods for drug development based on the methods for identifying drug targets.
Owner:FRED HUTCHINSON CANCER RES CENT
IN vitro sorting method
InactiveUS7138233B2High activityMicrobiological testing/measurementOxidoreductasesGene productGenetic element
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having a desired activity.
Owner:UK RES & INNOVATION LTD
Nucleic acids for high throughput screening of CpG-based immuno-agonist/antagonist
The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The invention further relates to methods of using such murine and non-murine TLR9 nucleic acids and polypeptides, especially in methods for screening for agonists and antagonists of immunostimulatory CpG nucleic acids. Also included are murine TLR9 inhibitors which inhibit murine TLR9 activity by inhibiting the expression or function of murine TLR9. In a further aspect the present invention pertains to murine TLR7 and murine TLR8, as well as related TLR7 and TLR8 molecules which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR7 and TLR8. Methods are included for screening for ligands of TLR7 and TLR8, as well as for inhibitors and agonists and antagonists of signaling mediated by TLR7 and TLR8.
Owner:COLEY PHARMA GMBH
Peptides and peptidomimetics with structural similarity to human P53 that activate P53 function
InactiveUS6245886B1Improve the immunityLow toxicityPeptide/protein ingredientsP53 proteinWild typeP53 Mutation
The present invention provides peptides and peptidomimetics corresponding to part or to the entirety of the region encompassed by residues 360-386 of human p53, said peptides and peptidomimetics characterized by the ability to activate DNA binding of wild-type p53 and to select tumor-derived p53 mutants. Pharmaceutical compositions of the compounds of the invention and methods of using these compositions therapeutically are also provided.
Owner:BAYER HEALTHCARE LLC +1
Directed evolution method
We describe a method of selecting an enzyme having replicase activity, the method comprising the steps of: (a) providing a pool of nucleic acids comprising members each encoding a replicase or a variant of the replicase; (b) subdividing the pool of nucleic acids into compartments, such that each compartment comprises a nucleic acid member of the pool together with the replicase or variant encoded by the nucleic acid member; (c) allowing nucleic acid replication to occur; and (d) detecting amplification of the nucleic acid member by the replicase. Methods for selecting agents capable of modulating replicase activity, and for selecting interacting polypeptides are also disclosed.
Owner:UK RES & INNOVATION LTD
Antisense oligonucleotides against VR1
InactiveUS7662948B2Reduce in quantityAvoid developmentOrganic active ingredientsFungiPain therapyNucleotide
Antisense oligodeoxynucleotides against VR1, corresponding nucleotide constructs, cells containing said nucleotide constructs, pharmaceutical and diagnostic substances, uses thereof in pain therapy, and methods for diagnosing symptoms related to VR1 and for identifying pain-modulating substances.
Owner:GRUNENTHAL GMBH
Topiramate sodium trihydrate
The invention encompasses novel salts of topiramate, and pharmaceutically acceptable polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, or amorphous forms thereof, as well as pharmaceutical compositions and pharmaceutical unit dosage forms containing the same. In particular, the invention encompasses pharmaceutically acceptable salts of topiramate, including without limitation topiramate sodium, topiramate lithium, topiramate potassium, or polymorphs, solvates, hydrates, dehydrates, co-crystals, anhydrous, and amorphous forms thereof. The invention further encompasses novel co-crystals or complexes of topiramate, as well as pharmaceutical compositions comprising them. The invention also encompasses methods of treating or preventing a variety of diseases and conditions including, but not limited to, seizures, epileptic conditions, tremors, cerebral function disorders, obesity, neuropathic pain, affective disorders, tobacco cessation, migraines, and cluster headache.
Owner:ORTHO MCNEIL PHARM INC
Optical sorting method
InactiveUS20050037392A1High activityMaterial analysis by observing effect on chemical indicatorMicrobiological testing/measurementOptical propertyGene product
The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce their respective gene products within the microcapsules; (c) sorting the genetic elements which produce the gene product having the desired activity using a change in the optical properties of the genetic elements. The invention enables the in vitro evolution of nucleic acids and proteins by repeated mutagenesis and iterative applications of the method of the invention.
Owner:MEDICAL RESEARCH COUNCIL
Mass spectrometric methods for biomolecular screening
InactiveUS6428956B1Rapid and simultaneous screeningImprove efficiencySugar derivativesNucleotide librariesBiological targetCombinatorial chemistry
Owner:IONIS PHARMA INC
Three hybrid assay system
InactiveUS7135550B2Organic active ingredientsPeptide/protein ingredientsMolecular biologySmall molecule ligand
The invention provides compositions and methods for isolating ligand binding polypeptides for a user-specified ligand, and for isolating small molecule ligands for a user-specified target polypeptide using an improved class of hybrid ligand compounds.
Owner:GPC BIOTECH AG
Patch clamp apparatus and technique having high throughput and low fluid volume requirements
InactiveUS6063260ALow sample volume requirementLower the volumeBioreactor/fermenter combinationsBiological substance pretreatmentsAutosamplerIon transfer
PCT No. PCT / EP95 / 02204 Sec. 371 Date Apr. 25, 1997 Sec. 102(e) Date Apr. 25, 1997 PCT Filed Jun. 7, 1995 PCT Pub. No. WO96 / 13721 PCT Pub. Date May 9, 1996Apparatus for carrying out patch clamp technique utilized in studying the effect of certain materials on ion transfer channels in biological tissue, and more particularly patch clamp apparatus utilizing an autosampler, such as those utilized with HPLC apparatus, to provide high throughput, is disclosed. The invention additionally includes novel microperfusion chamber assemblies capable of utilizing only small amounts of material to be tested and only small amounts of liquid carrier, thereby enabling many tests to be completed in a short period of time. The invention more broadly relates to a novel electrophysiology drug handling and application set up for screening of chemical substances while providing high throughput and requiring only low volume of solutions and samples to be tested. The invention also comprises several novel procedures for utilizing the apparatus of the invention.
Owner:SOPHION BIOSCI
Systems and methods for the identification of compounds in medical fluids using admittance spectroscopy
ActiveUS20100305499A1Resistance/reactance/impedenceMedical devicesAdmittance spectroscopySpectroscopy
Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.
Owner:BENNETT JAMES W +1
Mass spectrometric methods for biomolecular screening
InactiveUS6329146B1Rapid and simultaneous screeningImprove efficiencySugar derivativesNucleotide librariesBiological targetCombinatorial chemistry
The present invention provides methods for the determination of the structure of biomolecular targets, as well as the site and nature of the interaction between ligands and biomolecular targets. The present invention also provides methods for the determination of the relative affinity of a ligand for the biomolecular target it interacts with. Also provided are methods for screening ligand or combinatorial libraries of compounds against one or more than one biological target molecules. The methods of the invention also allow determination of the relative binding affinity of combinatorial and other compounds for a biomolecular target. The present invention further provides methods for the use of mass modifying tags for screening multiple biomolecular targets. In a preferred embodiment, ligands which have great specificity and affinity for molecular interaction sites on biomolecules, especially RNA can be identified. In preferred embodiments, such identification can be made simultaneously with libraries of ligands.
Owner:IONIS PHARMA INC
Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal
The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. The invention further provides methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1-mediated signal. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
Owner:GENETICS INST INC +2
Insulin and IGF-1 receptor agonists and antagonists
Peptide sequences capable of binding to insulin and / or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
Owner:NOVO NORDISK AS +1
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