2355results about "Testing medicinal preparations" patented technology

The invention discloses a traditional Chinese medicinal material authenticity identification platform, and relates to the technical field of traditional Chinese medicinal material authenticity identification, the traditional Chinese medicinal material authenticity identification platform comprises a data acquisition module, the data acquisition module is connected with a data analysis module, and the data analysis module is connected with a result display module; and the data acquisition module is used for acquiring appearance images, spectral data and background information of the traditional Chinese medicinal materials. According to the traditional Chinese medicine authenticity identification platform, traditional Chinese medicines are comprehensively analyzed from multiple angles, limitation of a single method is avoided, and identification accuracy is improved; the characteristics of the traditional Chinese medicinal materials are deeply analyzed to accurately judge authenticity and quality; the quality of the traditional Chinese medicinal materials is accurately evaluated by establishing a quantitative analysis model; the model is verified by adopting a cross validation method, so that the accuracy and stability are ensured, the identification accuracy is improved, and the problem that the traditional identification method is difficult to meet the requirement of quickly and accurately identifying the authenticity of the traditional Chinese medicinal materials is solved.

The present invention relates to the field of Internet of Things monitoring technology, specifically a Chinese herbal medicine drying monitoring system based on the Internet of Things, the system includes a gas component monitoring module, a density measurement and analysis module, a data anomaly correction module, a drying endpoint determination module, and a terminal data storage module. In the present invention, by acquiring gas concentration data within a fixed time window and analyzing the changing trend of the gas component ratio curve, the sensitivity to changes in the gas environment is improved, the density measurement adopts a multi-monitoring point method, the density change rate is calculated, and the gas component data is combined to form a multi-dimensional drying state analysis, reduce the impact of local errors on the overall judgment, detect abnormal fluctuations through trend consistency calculation, correct mutation data, prevent sudden measurement errors from interfering with the drying state determination, combine the gas component ratio change trend and the density change trend, adjust the drying endpoint determination basis, adapt to the drying characteristics of different batches of Chinese herbal medicines, and improve the accuracy of the drying endpoint determination.

The invention provides a full-automatic integrated traditional Chinese medicine detection method and equipment. Belongs to the technical field of traditional Chinese medicine detection and automation. The detection method comprises the following steps: shooting high-definition photos of traditional Chinese medicinal materials through a high-precision camera and an image processing unit which are arranged on a variety screening module, and comparing the high-definition photos with a built-in traditional Chinese medicinal material image database through a preset algorithm to automatically identify the types of the traditional Chinese medicinal materials; multi-dimensional quality detection is carried out on the traditional Chinese medicinal materials through multiple sensors integrated in the quality detection module; through the combination of the high-precision camera and the image processing unit and the application of the deep learning algorithm, the types of the traditional Chinese medicinal materials can be quickly and accurately identified, the detection efficiency is improved, and the possibility of human errors is also reduced.

The invention discloses an intelligent quality inspection system for medicinal empty capsules, particularly relates to the field of intelligent detection, and comprises a multi-dimensional optical characteristic acquisition module, a dynamic thermodynamic response analysis module, a near infrared spectrum component inversion module, a multi-source data fusion decision module and a self-adaptive feedback optimization module. Omnibearing nondestructive detection of the capsule is realized through non-contact multispectral imaging and vibration response analysis, traditional destructive sampling loss is thoroughly avoided, and the multisource data fusion module integrates optical texture features, mechanical frequency domain energy density and near infrared spectrum inversion values based on the D-S evidence theory, so that the detection accuracy is improved. And the self-adaptive optimization module dynamically adjusts an optical wavelength weight, a mechanical sweep frequency range and a spectrum modeling parameter by applying reinforcement learning, is self-adaptive to fluctuation of different batches of gelatin materials and environmental interference, remarkably reduces a misjudgment rate and ensures continuous and stable operation of a production line.

The invention discloses a comprehensive detection method for detecting the quality of a traditional Chinese medicine capsule, and relates to the technical field of medicine quality detection.According to the method, the quality fluctuation of a shell can be effectively recognized by monitoring the elasticity modulus of the shell of the capsule in real time and constructing a variable coefficient; and secondly, further monitoring is carried out aiming at capsule filling types and density uniformity, so that the uniformity of medicine filling is ensured, the medicine effect fluctuation caused by non-uniform filling is avoided, and the release consistency of the medicine is improved. And then, based on dissolution rate gradient monitoring under different temperature and pH value conditions, the dissolution characteristics of the capsule in various environments can be comprehensively evaluated, so that the dissolution performance stability of the capsule is guaranteed. And finally, accurately calculating a dissolution stable factor by combining the detection of trace dissolution substances with a dissolution characteristic analysis model, and further optimizing the quality evaluation of the capsules by combining a dissolution rate change coefficient, thereby reducing unqualified batches caused by uneven dissolution.

The invention relates to the technical field of material determination, and particularly discloses an intelligent screening method and system for traditional Chinese medicine decoction pieces, and the method comprises the steps: S1, obtaining decoction piece standard data of to-be-detected traditional Chinese medicine decoction pieces, collecting decoction piece physical data and decoction piece chemical data of the to-be-detected traditional Chinese medicine decoction pieces, and obtaining historical detection data of the to-be-detected traditional Chinese medicine decoction pieces; s2, calculating a feature deviation value of each feature in the physical feature vector of the to-be-detected traditional Chinese medicine decoction piece and a physical deviation value of the to-be-detected traditional Chinese medicine decoction piece; s3, constructing a chemical detection model, and determining chemical deviation data of the to-be-detected traditional Chinese medicine decoction pieces; and S4, determining the traditional Chinese medicine decoction piece grade of the to-be-detected traditional Chinese medicine decoction pieces and performing intelligent screening. According to the method, a comprehensive and accurate decoction piece standard system can be constructed, multi-dimensional and quantitative evaluation of the quality of the decoction pieces is realized, the grade of the decoction pieces is comprehensively and accurately judged, subjective errors and quality misjudgment are avoided, the screening efficiency and accuracy are improved, and a scientific solution is provided for quality control of traditional Chinese medicines.

The invention relates to the technical field of aplastic anemia (AA) treatment research, discloses a biomarker method for predicting the curative effect of cyclosporine on aplastic anemia, and aims to detect plasma differential metabolites of patients with aplastic anemia by adopting a metabonomics technology, find potential biomarkers for treating AA patients and find the curative effect of cyclosporine on the AA patients. CsA) is used for treating the in-vivo metabolism of AA. The method is based on liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS) technologies, and comprises the following steps: collecting 5 plasma samples of AA patients, 5 plasma samples of healthy people and 5 plasma samples of patients in a stable period after treatment for comparative analysis; and screening differential compounds by adopting a multivariate statistical method, and further performing enrichment analysis on differential metabolites. Research of the method shows that in-vivo metabolites of AA patients and healthy people are obviously different, and the way related to immunity and energy metabolism may be a key target for treating AA; csA intervenes the occurrence and development of AA by regulating and controlling immune-related metabolic ways.

A method of using the relaxation rate (R1 and / or R2) of solvent NMR signal to invasively or noninvasively assess whether vaccines and other aqueous-based pharmaceutical products have been frozen during transport and / or storage.

The present invention relates to a screening method for odor-suppressing materials. A screening method according to the present invention includes: causing a test substance and an odor-causing substance to act on at least one olfactory receptor polypeptide selected from the group consisting of olfactory receptor OR2AG2 and polypeptides that include an amino acid sequence having 80% or greater identity with the amino acid sequence of the aforementioned olfactory receptor and exhibit responsiveness to odor-causing substances; measuring the response of the olfactory receptor polypeptide to the odor-causing substance; and, on the basis of the measured response, identifying test substances that suppress a response of the olfactory receptor polypeptide as candidate substances for an odor-suppressing material.

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

The invention discloses a quality control method of a traditional Chinese medicine preparation based on an IV-catfish orifice-freeing prescription, and relates to the technical field of analysis of traditional Chinese medicine preparations, and the quality control method comprises the following steps: carrying out microscopic identification on traditional Chinese medicine components in the IV-catfish orifice-freeing prescription, and determining a pharmacodynamic material basis. According to the quality control method for the traditional Chinese medicine preparation based on the IVV orifice-freeing prescription, various evaluation means such as a drug effect equivalent evaluation index, a stability test, a quality test and a clinical test are comprehensively applied, the consistency and reliability of the curative effect of the traditional Chinese medicine preparation can be remarkably improved, and the drug effect equivalent evaluation index is analyzed from the two factors of drug effect intensity and action time; the method ensures the equivalence of the medicinal component group and the original traditional Chinese medicine preparation, comprehensively detects the raw material medicines and the preparation, including characters, identification, inspection and content determination items, and ensures that the quality of each batch of samples meets the standard, so that the curative effect of the traditional Chinese medicine preparation is effectively guaranteed, and the efficacy of the traditional Chinese medicine preparation is improved.

The invention discloses a quality inspection system for a production process of an amomum tsao-ko mixture for guiding qi downward and dredging collaterals, and aims to realize comprehensive monitoring and control of the production process through multiple modules and improve the product quality and the production efficiency. The image data acquisition module is used for acquiring raw material and production process images and spectral analysis images. The timing module records and judges the production process time. The multi-source data acquisition module collects production environment data and raw material weight. The raw material proportion control module monitors a raw material proportion. And the data processing module is used for analyzing and processing images and environment data in the production process. And the user interaction module provides an interface for real-time quality detection results and user modification commands. Through comprehensive data acquisition and processing, intelligent proportion control, accurate time management and efficient environmental condition evaluation, the production quality and safety of the amomum tsao-ko mixture for guiding qi downward and dredging collaterals are remarkably improved, human errors are reduced, and the production efficiency is improved.

The invention relates to the technical field of disintegration time limit automatic induction, in particular to a disintegration time limit inductive sensor capable of preventing refraction interference. A disintegration time limit inductive sensor capable of preventing refraction interference comprises a tube body which is internally provided with a medicine soaking cavity; the conical screen cover corresponds to the bottom of the medicine soaking cavity, the diameter of the upper end of the conical screen cover is larger than that of the lower end of the conical screen cover, and the lower end of the conical screen cover corresponds to the center of the medicine soaking cavity and is provided with an opening; the photoelectric sensor comprises a transmitter and a receiver, the transmitter is fixed below the conical screen cover, and a transmitting port of the transmitter is right opposite to an opening in the lower end of the conical screen cover; the floating head is arranged in the medicine soaking cavity, the receiver is installed in the floating head, and the receiving end of the receiver is exposed out of the bottom of the floating head and right faces the emitting opening of the emitter. And the detection precision of the photoelectric sensor can be effectively prevented from being influenced by refraction and liquid sputtering.

The invention provides an automatic screening platform and a screening method.The automatic screening platform comprises an automatic screening device, a driving mechanism, a temperature control module and an electric control module, the automatic screening device is provided with a first cavity, an incubation cavity and a plurality of functional cavities, an injection mechanism is arranged in the first cavity and comprises an injection push rod with a piston, and the injection push rod is connected with the incubation cavity; the rotating module is in transmission connection with the switching mechanism to control the switching mechanism to rotate; the driving mechanism can clamp the injection push rod; the temperature control module is used for heating the incubation cavity; the electric control module is electrically connected with the rotating module, the driving mechanism and the temperature control module so as to control the driving mechanism and the temperature control module to work cooperatively; according to the automatic screening platform, all operation steps of a screening experiment are integrated, all the screening steps are integrated in the automatic screening device, contact with the outside is little, and external pollution and assembly pollution are reduced; the whole experiment process is high in automation degree, so that the experiment is more standardized and unified.

To provide a method for evaluating disposition and / or effect of a candidate compound in an in-vitro culture and / or suspension to predict in-vivo disposition and / or effect of the candidate compound.SOLUTION: A method comprises the steps of: providing a cell culture and / or suspension; exposing a candidate compound to the culture and / or suspension; exposing the culture and / or suspension to a culture medium providing an extracellular environment related to in vivo (the culture medium contains a certain component (e.g., protein or the like) at a concentration having characteristics (e.g., binding characteristics) similar to physiological concentration or physiologic concentration), wherein arbitrary combination of any of the "exposing steps" can occur in any order or simultaneously; and evaluating in-vitro disposition and / or effect of the candidate compound to predict in-vivo disposition and / or effect of the candidate compound.SELECTED DRAWING: None

The utility model provides a pH detecting and adjusting system for flunixin synthesis. The pH detecting and adjusting system comprises a reactor, and a motor, a pH adjusting agent inlet, a reflux inlet and a reactant inlet are arranged at the top of the reactor. A product outlet is also formed in the bottom of the reactor. A first valve is mounted at the pH regulator inlet, a second valve and a third valve which are connected in parallel are connected to the product outlet, a filtering device, a circulating pump and a pH detection device are sequentially connected behind the third valve in the material flowing direction, and the pH detection device is connected with the reflux liquid inlet. According to the system provided by the utility model, solid materials in the materials are filtered through the filtering device, so that the interference of the solid materials on a pH detection result is reduced. Meanwhile, the pH detection device can detect the pH value of the material in the reactor in real time, is convenient and rapid, does not need manual sampling, reduces the labor intensity and danger of workers, does not overflow the material or peculiar smell in the detection process, and is safer and more efficient.

Provided are a method and the like for efficiently screening for a candidate substance for a starting material that suppresses hexanal odor. The screening method according to the present invention comprises the steps of: adding a test substance and hexanal to a specific olfactory receptor polypeptide; a step for measuring the response of the olfactory receptor polypeptide to hexanal; and identifying, on the basis of the measured response, a test substance that inhibits the response of the olfactory receptor polypeptide as a candidate substance for a raw material that inhibits hexanal odor.

The invention relates to the technical field of levocarnitine injection preparation devices, in particular to a levocarnitine injection and a preparation device thereof. Comprising the following raw materials in percentage by mass: 18%-22% of levocarnitine, 5%-10% of a vitamin antioxidant, 28%-33% of a traditional Chinese medicine extract, a pH regulator and the balance of water for injection, the traditional Chinese medicine composition is prepared from the following components in percentage by mass: 10% of ginseng extract, 10% of fructus lycii extract, 20% of radix astragali extract, 10% of radix salviae miltiorrhizae extract, 8% of fructus schisandrae chinensis extract, 14% of radix notoginseng extract and the balance of pure water. Through combined use of levocarnitine and traditional Chinese medicines, it is found that mixed injection of levocarnitine, the vitamin antioxidant and the traditional Chinese medicine extract has a better treatment effect than independent injection, and the mixed injection shows a more remarkable synergistic effect.

The invention discloses a method for predicting or evaluating the stability of an mRNA-LNP liquid preparation and application of the method, and belongs to the technical field of medicine quality control, and the method comprises the following steps: centrifuging the mRNA-LNP liquid preparation, balancing, putting the mRNA-LNP liquid preparation into a multifunctional protein stability analyzer, and analyzing the stability of the mRNA-LNP liquid preparation. According to the method, the change of the turbidity, the hydraulic radius and the intermolecular interaction of the mRNA-LNP liquid preparation along with the temperature is tested, the stability evaluation temperature Tstability is calculated, the comprehensive stability score Sstability is obtained according to the data obtained through the test and the Tstability, and the higher the Sstability is, the better the stability of the mRNA-LNP liquid preparation is. The method is suitable for preparation development and quality control in the fields of mRNA vaccines, gene therapy and the like, is efficient, label-free and good in accuracy, and can be used for improving the stability and research and development efficiency of the preparation.

To provide a new composition consisting of 100% natural matter, exerting a therapeutic or beneficial effect in the treatment of bone fragility, having a physiological mode of action.SOLUTION: The present invention provides a 100% natural product consisting of natural matrices exhibiting emerging properties, which enables re-establishing correct bone metabolism by correcting behavior of mesenchymal stem cells and re-establishing a correct balance between cell populations that allow bone growth or remodeling. The natural product consists of, for example, Equisetum flowering tops, Acacia, Malpighia fruit, coral skeleton, avian eggshell, Agave leaves, Cetraria stems, Agaricus, and calcium citrate.SELECTED DRAWING: None

The invention discloses a method for detecting and identifying a traditional Chinese medicine evodia base based on electronic nose smell, and belongs to the technical field of traditional Chinese medicinal materials and quality analysis and detection. To-be-detected powder is injected through a headspace sample injection bottle and detected through an electronic nose, a sensor response value is obtained, W1S serves as a differential sensor, W6S serves as a reference sensor, and the basis of the traditional Chinese medicine fructus evodiae is determined according to the ratio of the W1S response value to the W6S response value; when the response value ratio of the W1S to the W6S is 2.4-3.1, the product is evodia rutaecarpa, when the response value ratio of the W1S to the W6S is 3.5-5.2, the product is botrytis chinensis, and when the response value ratio of the W1S to the W6S is 5.8-6.5, the product is evodia rutaecarpa. The method for detecting and identifying the traditional Chinese medicine evodia base on the basis of the electronic nose smell, provided by the invention, has the advantages of rapidness, no damage, no need of complex sample pretreatment, simplicity, environmental protection, low detection cost and visual result, and is suitable for rapidly, objectively and accurately judging the traditional Chinese medicine evodia base in batches.

The invention relates to the technical field of traditional Chinese medicine decoction piece screening, and discloses an intelligent traditional Chinese medicine decoction piece screening method based on multi-modal data fusion. The method comprises the following steps: synchronously acquiring visible light image data, near infrared spectrum data and smell volatile matter data of a target traditional Chinese medicine decoction piece through a multi-source sensor array; respectively performing morphological cleaning, baseline drift correction and environmental interference elimination operations on the three types of data; extracting a form feature set, a chemical component feature set and a volatile substance feature set of the decoction pieces from the preprocessed data; calculating morphological stability factors, component stability factors and volatilization stability factors corresponding to the three types of feature sets; constructing a three-dimensional feature fusion space, and mapping the three types of feature sets into fusion feature vectors; executing centralized search in the space by taking the fusion feature vector as a starting point, and determining an optimal screening decision vector; therefore, more accurate grade classification and quality screening are realized, and the screening efficiency of the traditional Chinese medicine decoction pieces can be remarkably improved.

The invention relates to the technical field of medicine quality detection, in particular to a capsule medicine multi-mode defect detection system and a multi-dimensional detection method, and the detection system comprises a detection container filled with an intelligent response type medicinal silicone oil composition, a transmission system, a detection mechanism, a control system and a rejection mechanism. Through density adjustment, temperature-sensitive-fluorescence response and multi-mode detection technologies, accurate detection of defects such as capsule liquid leakage, cracks and poor sealing can be realized. The detection method adjusts the silicone oil density according to the capsule type, and collects, fuses and analyzes buoyancy signals and optical image data to judge defects. According to the invention, the detection precision is high, and 0.02 [mu] L-level leakage and 0.1 mm-level cracks can be detected; the compatibility is strong, and the method is suitable for 95% of commercially available capsules; the cost is low, the equipment and maintenance cost is greatly reduced, and silicone oil can be recycled; the medicine production specifications are met.

The invention discloses an effectiveness analysis method of a drug entrapment material for treating intrauterine adhesion. The effectiveness analysis method comprises the following steps: performing multi-aspect research on the drug entrapment material and generating an effectiveness analysis result. In performance characterization, the morphology and pores of the material are analyzed by using microscopy, specific surface area and other technologies, the compatibility of the drug and the carrier is verified, and the physical state of the drug is detected; in-vitro analysis covers drug release kinetics, the release amount is measured in a simulated environment, and a curve is fitted; the biocompatibility evaluation refers to co-culture of a material leaching solution and cells, detection of cell activity and the like; implanting a medicine carrying material into the animal model in vivo, and evaluating the curative effect by using technologies such as image and pathology; and finally, integrating various results to obtain an entrapment material effectiveness analysis conclusion. According to the method, the limitation of traditional single-point testing is broken through, a full-chain evaluation model of structural characteristics-release behavior-biocompatibility-repair efficiency is constructed, and a scientific basis is provided for rational design and clinical transformation of intrauterine adhesion treatment materials.

The invention discloses a traditional Chinese medicine analysis and identification method and system based on clustering analysis, and relates to the technical field of traditional Chinese medicine analysis, and the method comprises the following steps: S1, collecting a chemical fingerprint spectrum, a microscopic image, metabonomics data and geographical indication information of a traditional Chinese medicine sample; according to the traditional Chinese medicine analysis and identification method and system based on clustering analysis, through a dynamic weight distribution mechanism and a high-order nonlinear collaborative characterization technology, the core problem of multi-modal data fusion failure in traditional Chinese medicine identification is effectively solved; the dynamic weight distribution network adaptively adjusts the contribution degree of each modal based on real-time entropy fluctuation and sample density, so that the identification precision under complicated scenes such as related species and processed product difference is remarkably improved; the high-order tensor fusion space is combined with adversarial generation training, the characterization limitation of a linear kernel function on component-form-effect nonlinear correlation is broken through, and the clustering boundary better fits the overall characteristics of traditional Chinese medicine.

Provided are an expression inhibitor of a cancer promoting factor based on the discovery of a new factor influencing the expression amount / level of a cancer promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for cancer. More specifically provided are: an expression inhibitor of a cancer promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS expression inhibitor and RBMS function inhibitor; a screening method using as an indicator the expression or the function of RBMS; an expression cassette useful for the method; as well as a diagnostic agent containing a product detection agent for RBMS gene expression and cancer detection method using as an indicator RBMS gene expression amount / level.

The invention discloses a quality control method based on a levocarnitine oral solution preparation process, and relates to the technical field of quality detection. The quality control method based on the preparation process of the levocarnitine oral solution comprises the following steps: acquiring oral solution monitoring data; evaluating oral liquid quality; feeding back a result; and optimizing quality control parameters. According to the method, oral liquid quality evaluation is carried out through the obtained oral liquid monitoring data, the process quality feedback data is obtained, then the process parameter algorithm model is constructed according to the process quality feedback data, result feedback is carried out, and finally whether quality control parameter optimization is carried out or not is judged based on the process parameter algorithm model. The effect of improving the character stability of the prepared levocarnitine oral solution is achieved, and the problem that in the prior art, the quality of the prepared levocarnitine oral solution is difficult to control is solved.

Disclosed are a method, a device, and an information processing program for determining, by using refractive index distribution data pertaining to an object to be observed, the region of a cell that has undergone programmed cell death in the object to be observed.

A transmitting terminal (1A) transmits first D2D control information (522, 523) in one or more subframes within a first subframe pool (511) within a first D2D control period (501) and performs data transmission (531-534) in accordance with the first D2D control information (522, 523) in one or more subframes within a second subframe pool (512) within the first D2D control period (501). The first D2D control information (522, 523) contains a second information element indicating whether the first D2D control information (522, 523) is valid in at least one D2D control period (502, 503) occurring after the first D2D control period (501). This makes it possible to contribute, for example, to reducing failure in reception of scheduling assignment information that is transmitted in a radio resource region for control in a periodic D2D control period and that specifies D2D transmission resources.

The present invention provides methods and compositions for treating cancer and / or autoimmune diseases by modulating the expression and / or activity of IGSF8 and its binding ligand. Pharmaceutical compositions include, but are not limited to, antibodies that specifically bind to human IGSF8 and have the activity of inhibiting IGSF8-mediated immunosuppression in a subject in need thereof. Pharmaceutical compositions may include, but are not limited to, antibodies that specifically bind to human IGSF8 and have the activity of inhibiting IGSF8-mediated immunosuppression in a subject in need thereof.