1166results about "Testing medicinal preparations" patented technology

The invention discloses an intelligent quality inspection system for medicinal empty capsules, particularly relates to the field of intelligent detection, and comprises a multi-dimensional optical characteristic acquisition module, a dynamic thermodynamic response analysis module, a near infrared spectrum component inversion module, a multi-source data fusion decision module and a self-adaptive feedback optimization module. Omnibearing nondestructive detection of the capsule is realized through non-contact multispectral imaging and vibration response analysis, traditional destructive sampling loss is thoroughly avoided, and the multisource data fusion module integrates optical texture features, mechanical frequency domain energy density and near infrared spectrum inversion values based on the D-S evidence theory, so that the detection accuracy is improved. And the self-adaptive optimization module dynamically adjusts an optical wavelength weight, a mechanical sweep frequency range and a spectrum modeling parameter by applying reinforcement learning, is self-adaptive to fluctuation of different batches of gelatin materials and environmental interference, remarkably reduces a misjudgment rate and ensures continuous and stable operation of a production line.

The invention provides a therapeutic drug monitoring kit and method and system, a magnetic bead extraction method is combined with LC-MS / MS detection to be applied to human blood drug concentration monitoring, a mixed magnetic bead solution containing phospholipid removal magnetic beads and to-be-detected drug adsorption magnetic beads is utilized to perform adsorption and extraction pretreatment on a to-be-detected drug in a sample, automatic treatment equipment is matched, and the concentration of the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug in the to-be-detected drug is detected. The pretreatment efficiency is high, the phospholipid content in the supernate is low, and the matrix effect and the chromatographic column washing pressure are greatly reduced. According to the therapeutic drug monitoring method provided by the invention, a unified pretreatment process is used, simultaneous extraction of multiple drugs is realized, and through a magnetic bead automatic extraction method, the pretreatment step of a sample can be rapidly completed, a therapeutic drug monitoring result can be rapidly obtained, the overall detection time is shortened, and the detection efficiency is improved. Therefore, a reliable laboratory examination basis is provided for individualized treatment.

To provide a method for evaluating disposition and / or effect of a candidate compound in an in-vitro culture and / or suspension to predict in-vivo disposition and / or effect of the candidate compound.SOLUTION: A method comprises the steps of: providing a cell culture and / or suspension; exposing a candidate compound to the culture and / or suspension; exposing the culture and / or suspension to a culture medium providing an extracellular environment related to in vivo (the culture medium contains a certain component (e.g., protein or the like) at a concentration having characteristics (e.g., binding characteristics) similar to physiological concentration or physiologic concentration), wherein arbitrary combination of any of the "exposing steps" can occur in any order or simultaneously; and evaluating in-vitro disposition and / or effect of the candidate compound to predict in-vivo disposition and / or effect of the candidate compound.SELECTED DRAWING: None

The invention relates to the technical field of traditional Chinese medicine decoction piece screening, and discloses an intelligent traditional Chinese medicine decoction piece screening method based on multi-modal data fusion. The method comprises the following steps: synchronously acquiring visible light image data, near infrared spectrum data and smell volatile matter data of a target traditional Chinese medicine decoction piece through a multi-source sensor array; respectively performing morphological cleaning, baseline drift correction and environmental interference elimination operations on the three types of data; extracting a form feature set, a chemical component feature set and a volatile substance feature set of the decoction pieces from the preprocessed data; calculating morphological stability factors, component stability factors and volatilization stability factors corresponding to the three types of feature sets; constructing a three-dimensional feature fusion space, and mapping the three types of feature sets into fusion feature vectors; executing centralized search in the space by taking the fusion feature vector as a starting point, and determining an optimal screening decision vector; therefore, more accurate grade classification and quality screening are realized, and the screening efficiency of the traditional Chinese medicine decoction pieces can be remarkably improved.

The invention discloses an effectiveness analysis method of a drug entrapment material for treating intrauterine adhesion. The effectiveness analysis method comprises the following steps: performing multi-aspect research on the drug entrapment material and generating an effectiveness analysis result. In performance characterization, the morphology and pores of the material are analyzed by using microscopy, specific surface area and other technologies, the compatibility of the drug and the carrier is verified, and the physical state of the drug is detected; in-vitro analysis covers drug release kinetics, the release amount is measured in a simulated environment, and a curve is fitted; the biocompatibility evaluation refers to co-culture of a material leaching solution and cells, detection of cell activity and the like; implanting a medicine carrying material into the animal model in vivo, and evaluating the curative effect by using technologies such as image and pathology; and finally, integrating various results to obtain an entrapment material effectiveness analysis conclusion. According to the method, the limitation of traditional single-point testing is broken through, a full-chain evaluation model of structural characteristics-release behavior-biocompatibility-repair efficiency is constructed, and a scientific basis is provided for rational design and clinical transformation of intrauterine adhesion treatment materials.

Disclosed are a method, a device, and an information processing program for determining, by using refractive index distribution data pertaining to an object to be observed, the region of a cell that has undergone programmed cell death in the object to be observed.

The present invention provides methods and compositions for treating cancer and / or autoimmune diseases by modulating the expression and / or activity of IGSF8 and its binding ligand. Pharmaceutical compositions include, but are not limited to, antibodies that specifically bind to human IGSF8 and have the activity of inhibiting IGSF8-mediated immunosuppression in a subject in need thereof. Pharmaceutical compositions may include, but are not limited to, antibodies that specifically bind to human IGSF8 and have the activity of inhibiting IGSF8-mediated immunosuppression in a subject in need thereof.

The present invention provides a technology for predicting the level of PPO inhibition objectively and with high accuracy using LUMO distribution as a "molecular descriptor," and a technology for selecting a PPO inhibitor based on the predicted level of PPO inhibition. [Solution] The present invention provides a method for predicting PPO inhibitory activity based on the correlation between LUMO distribution and PPO inhibitory activity for each compound, predicting the level of PPO inhibitory activity based on the correlation between the difference in variation in PPO inhibitory activity between different plant species and the level of PPO inhibitory activity, and selecting PPO inhibitors using the predicted PPO inhibitory activity as an index.

To assess the potential of a new chemical entity (NCE), compound or drug candidate to cause cholestatic hepatotoxicity in vivo.SOLUTION: A method of screening a compound for its potential to cause systemic or hepatic toxicity comprises the steps of: providing a compound to be screened; establishing a hepatic cell system (HCS) having a capacity for bile acid synthesis, bile acid transport and / or bile acid regulation; exposing the hepatic cell system (HCS) to a range of concentrations of a bile acid to determine a toxicity profile of the bile acid, where the bile acid toxicity profile comprises a toxicity potency; exposing the hepatic cell system (HCS) to a range of concentrations of a bile acid in the presence of the compound to be screened and determining a toxicity profile of the bile acid, where the bile acid toxicity profile comprises a toxicity potency; and comparing the toxicity potency of the bile acid to determine the susceptibility of the compound to cause systemic and / or hepatic toxicity.SELECTED DRAWING: None

A model that closely resembles human excessive myopia can be prepared by mounting a minus lens (2) and a protector (4) to a juvenile mouse, the minus lens having an angle and a width adjustable in response to growth of the mouse. Further, this model analysis shows that myopia induction causes endoplasmic reticulum stress in a sclera and the endoplasmic reticulum stress induces myopia. Furthermore, it is revealed that an endoplasmic reticulum stress suppressant, particularly, phenylbutyrate and tauroursodeoxycholic acid act as a myopia prevention / suppression agent.

The invention discloses a microsphere-shaped ceftiofur hydrochloride nanoemulsion injection preparation device and a production process, and relates to the technical field of injection preparation equipment, and the microsphere-shaped ceftiofur hydrochloride nanoemulsion injection preparation device comprises a sterile tank body and a supporting piece; a first mounting frame and a second mounting frame are arranged on one side of the supporting piece, the first mounting frame is rotationally connected to the supporting piece, the second mounting frame is rotationally connected to the first mounting frame, the rotating axis of the first mounting frame is perpendicular to the rotating axis of the second mounting frame, and the sterile tank body is fixedly connected with the second mounting frame; the axis of the sterile tank body is eccentrically arranged relative to the rotating axis of the second mounting frame, and the sterile tank body rotates around the rotating axis of the first mounting frame while rotating along with the second mounting frame, so that the sterile tank body does three-dimensional compound motion in the space; a stirring disc is movably arranged in the sterile tank body, and the stirring disc can reciprocate in the sterile tank body along the axis direction of the sterile tank body by virtue of the gravity of the stirring disc. The device has the effects of enhancing the material mixing effect and the sampling randomness.

Disclosed are compositions and methods useful for targeting and internalizing molecules into cells of interest and for penetration by molecules of tissues of interest. The compositions and methods are based on peptide sequences that are selectively internalized by a cell, penetrate tissue, or both. The disclosed internalization and tissue penetration is useful for delivering therapeutic and detectable agents to cells and tissues of interest.

The invention provides a traditional Chinese medicine decoction piece quality evaluation method based on big data, and relates to the technical field of data processing, and the method comprises the steps: extracting texture direction consistency data from texture dense region detection points of a central region, and extracting structural symmetry data from wrinkle region detection points; comparing the color gradient change data with a preset standard color gradient threshold to generate a first difference index, comparing the texture direction consistency data with a historical qualified batch texture direction distribution range to generate a second difference index, and comparing the structural symmetry data with a pharmacopoeia form standard to generate a third difference index; and calculating a quality evaluation value based on the first difference index, the second difference index and the third difference index in combination with the initial quality deviation risk value, and obtaining a quality grade judgment result of the traditional Chinese medicine decoction pieces according to an interval matching relationship between the quality evaluation value and a preset risk threshold. According to the invention, the evaluation accuracy can be improved.

Systems and methods are disclosed for determining the spatial distributions of radionuclides in tissue samples via mass spectrometry imaging. After administration of a radiopharmaceutical that contains a radionuclide, a mass spectrometry imaging system, such as an imaging mass cytometer or a multiplexed ion beam imaging system, is employed to interrogate a tissue sample to obtain a dataset. The radiopharmaceutical includes, or generates via radioactive decay of the radionuclide, a metal isotope detectable by the mass spectrometry imaging system. The dataset is processed to determine a spatial distribution of the metal isotope within the tissue sample, thereby characterizing the spatial distribution of the radionuclide delivered within the tissue sample. The tissue sample may be stained with a biomarker reagent that includes an additional metal isotope attached to a biomarker ligand, enabling the spatially multiplexed and co-registered analysis. The present methods can be adapted to infer and assess localization of non-radioactive pharmaceuticals.

The invention relates to the technical field of data processing, in particular to a process detection method for a manufacturing process of a chicory preparation, which comprises the following steps: acquiring a concentrated solution concentration data sequence and a corresponding chicoric acid yield data sequence in the manufacturing process of the chicory preparation under each ethanol concentration; dividing each concentrated solution concentration data sequence into at least two stage sequences according to data change characteristics in each concentrated solution concentration data sequence; each concentrated solution concentration data sequence is divided into at least two subsequences, and according to the data difference of the subsequences contained in each stage sequence in each concentrated solution concentration data sequence and the fluctuation characteristics of the concentrated solution concentration data in each stage sequence, the concentrated solution concentration data in each stage sequence is obtained; according to the method, the stage influence weight of each stage sequence in each concentrated solution concentration data sequence is obtained according to the concentration data sequence of each concentrated solution and the similarity between each concentrated solution concentration data sequence and the corresponding chicoric acid yield data sequence, a regression analysis model is constructed, and the accuracy of a regression analysis result is improved.

The invention provides a traditional Chinese medicine preparation quality detection method and system based on multi-dimensional data analysis, and belongs to the technical field of traditional Chinese medicine preparation quality detection. The method comprises the following steps: acquiring mass spectrum data and nuclear magnetic resonance data of various active components in a preparation to generate a multi-dimensional chemical characteristic data set; synchronously collecting corresponding data of the medicinal raw materials, and constructing a process and environment association database; constructing a chemical and process coupling analysis model; and monitoring the production process in real time to obtain the dynamic chemical fingerprint spectrum. By constructing a full-component chemical map and associating the full-component chemical map with process and environmental parameters and combining clinical curative effect data to establish a drug effect and component response curved surface model, the limitation that only a few index components are concerned in traditional detection is broken through, so that a detection result can accurately reflect the multi-target and overall regulation characteristics of the traditional Chinese medicine preparation, and the detection accuracy is improved. The problem that the components are qualified but the curative effect is poor due to single detection dimension is avoided, and the relevance between quality detection and the clinical curative effect is remarkably improved.

Methods and apparatus (10) for Raman spectral analysis of a sample (12), such as a pharmaceutical dosage form, are disclosed. Delivery optics (16) are used to deliver probe light to a delivery region (13) on the sample, and collection optics (20) are used to collect, from a collection region (17) on the sample spaced from the delivery region, the probe light following scattering through the sample. Each of a plurality of target Raman spectral features are measured in the collected light, and a spectral distortion of the collected light arising during scattering through the sample is determined. A property of the sample is then quantified using the target Raman spectral features in combination with the determined spectral distortion, such that the quantified property is compensated for the spectral distortion.

The present invention relates to a method and apparatus for predicting the effect of the co-administration of a secondary active compound on the bioavailability of a primary active compound.

The present invention provides a photoelectric detection sensor for antibiotic resistance genes, its preparation method, and application. The present invention designs a Bi2S3 / ZnIn2S4 heterojunction as a photoelectric material, combined with a method of fixing electron donors with aptamers, to construct a biosensor system for detecting resistance genes. The system consists of two parts: catalytic hairpin self-assembly and DNAzyme cleavage. Compared with the prior art, the present invention can fix the electron donor through the aptamer, and cyclically amplify the target through the method of catalytic hairpin self-assembly. The recognition interaction between nucleic acids can achieve quantitative detection of CTX-M-15, which is simple to operate and highly sensitive.

An object of the present invention is to provide a lipocalin-type prostaglandin D2 synthase (L-PGDS) production promoting agent, more specifically an L-PGDS production promoting agent in pericytes or ischemia-induced multipotent stem cells (iSCs) dedifferentiated from pericytes. In the present invention, it has been found that a substance having an L-PGDS production promoting action is contained in an extract from inflamed tissues inoculated with vaccinia virus. An L-PGDS production promoting agent is highly useful as a preventive, therapeutic or relapse preventive agent for a disease in which the effect by promotion of L-PGDS expression is expected to be effective, including a cerebrovascular disorder such as cerebral infarction, dementia such as Alzheimer's disease, or a sleep disorder.

The invention relates to the technical field of traditional Chinese medicines, in particular to a processing method and a quality control method for toxicity reduction and efficacy enhancement of radix cynanchi bungei. According to the method, the content of alangiine, the content of ellagic acid, the common peak area of characteristic peaks and the content of water-soluble extracts in the wine-roasted berberis scenting decoction pieces are measured by adopting a high performance liquid chromatography (HPLC) method, and subjective assignment is carried out on the characters of the wine-roasted berberis scenting decoction pieces by combining Delphi evaluation to serve as evaluation indexes; the method comprises the following steps: determining the weight coefficient of each index by adopting an analytic hierarchy process-index repeatability correlation mixed weighting method (AHP-CRITIC), and screening the optimal wine roasting process of the Zhuang medicine Tibetan scene by combining the three factors of the frying temperature, the frying time and the yellow wine amount with star point design (CCD)-effect surface (RSM) according to the coefficients. And finally determining the optimal process of stir-frying the radix berberidis with wine as follows: the stir-frying temperature is 150 DEG C, the stir-frying time is 16min, the amount of yellow rice wine is 10%, and moistening is performed for 24h.

The present invention aims to provide a method for evaluating the serotonin reuptake inhibitory effect of a composition containing valerian extract. [Solution] The present invention provides a method for evaluating antidepressant effects, which involves quantitatively analyzing one or more components contained in at least a part of a plant of the genus Valerian or a processed product thereof, and evaluating the antidepressant effect of the test substance by referring to the results of the quantitative analysis and criteria for antidepressant effect.

One embodiment according to this invention provides a method for selecting an additive agent for suppressing a nitrosation reaction. Alternatively, one embodiment of the present invention provides a formulation that suppresses the generation of nitroso compounds, including an additive agent selected by a method for selecting an additive agent for suppressing a nitrosation reaction. In one embodiment, a method for selecting an additive agent for suppressing a nitrosation reaction includes adding an amine source and an NOx source to an additive agent to generate nitroso compounds, quantifying an amount of the generated nitroso compounds, and evaluating a suppressing effect of the nitrosation reaction of the additive agent based on the amount of the generated nitroso compounds.

The utility model discloses a device for measuring the residence time of a nasal preparation in nasal mucosa, which comprises a test plate with a plurality of test channels, a constant-temperature base and optionally a transparent cover body. The test channel is covered with a carrier for bearing nose simulation liquid, the constant-temperature base is hollow, a water inlet is formed in one side of the bottom end of the constant-temperature base, a water outlet is formed in one side of the top end of the constant-temperature base, so that a constant-temperature medium can pass through, and a device for displaying temperature is arranged on the test plate or the constant-temperature base. By adopting the novel device for measuring the residence time of the nasal preparation in the nasal mucosa, the nasal cavity environment including temperature, humidity, mucosa surface liquid composition, the inclination angle between the nasal cavity structure and the face and the like can be simulated to a certain extent, and prescription comparison with high flux and good parallelism can be carried out, so that development and evaluation of the nasal preparation are efficiently assisted.

To provide a method for analyzing Gla modification levels in vitamin K dependent protein.SOLUTION: An analytical method at least comprises the steps of: digesting vitamin K dependent protein with chymotrypsin, to cleave a Gla domain, to obtain Gla domain peptides; and sorting the Gla domain peptides by liquid chromatography according to the Gla modification levels. Such an analytical method enables the Gla modification levels to be determined quantitatively and qualitatively.SELECTED DRAWING: Figure 2

In some examples, a sensor for detecting dextrose includes at least one working electrode including Cu and being configured to electro-oxidize dextrose in an aqueous solution. The sensor further includes at least one counter electrode. In some examples, a system includes a fluid line, a dextrose container, a peritoneal dialysis container, and the sensor. The fluid line is configured to transport water. The dextrose container is configured to introduce dextrose in the fluid line to generate a peritoneal dialysis composition comprising the water and dextrose. The peritoneal dialysis container is downstream of the dextrose container and configured to receive the peritoneal dialysis composition. The sensor may be configured to detect dextrose in the peritoneal dialysis composition.

The utility model discloses a pretreatment device for medicine inspection. The pretreatment device comprises a medicine dissolving tank, a filtering tank and a medicine dissolving solution collecting tank which are communicated with one another, the medicine dissolving tank is also communicated with a solvent storage tank; a stirring device is arranged in the medicine dissolving tank, the stirring device comprises a stirring shaft rotationally arranged in the medicine dissolving tank and a stirring motor connected with the stirring shaft, a plurality of crushing teeth are arranged on the stirring shaft, and the medicine dissolving tank is sleeved with a grinding cylinder on the outer side of the stirring device; a plurality of filtering holes are formed in the side wall of the grinding cylinder, a plurality of first grinding teeth are further arranged on the side wall of the grinding cylinder, and the first grinding teeth and the smashing teeth are arranged in a staggered mode; and an electric heating sheet is arranged in the solvent storage tank. The device can effectively grind and crush medicines, can also control the dissolving temperature, and greatly improves the crushing and grinding effect and dissolving efficiency of the medicines.