59 results about "Ceftiofur Hydrochloride" patented technology

The invention discloses a preparation process for compound recipe ceftiofur oil suspensoid injection. The preparation process comprises the following steps: (1) taking neutral soybean oil, filtrating, heating and sterilizing and cooling down the soybean oil, adding aluminum stearate into the soybean oil to prepare gel, diluting the gel into factice of 2+-0.2 percent through the filtrated and sterilized soybean oil, and filtrating the factice through a No.3 sintered glass funnel for standby; and (2) taking hydrochloric acid ceftiofur/sulbactam according to a recipe, mixing the hydrochloric acid ceftiofur/sulbactam with the factice, grinding the mixture, adding lecithin into the mixture till the mixture is ground evenly, and then obtaining the compound recipe ceftiofur oil suspensoid injection through shifting the ground hydrochloric acid ceftiofur/sulbactam into a graduated cylinder and so on. As the invention adopts the preparation method, compared with a single recipe ceftiofur preparation, the compound recipe ceftiofur oil suspensoid injection has the advantage that the compound recipe ceftiofur oil suspensoid injection has antibacterial activity against bacteria capable of resisting the single recipe ceftiofur, that is, the compound recipe ceftiofur oil suspensoid injection can effectively treat bacterial infection generating ESBLs.

The invention provides a pulmonary targeting microsphere of veterinary ceftiofur hydrochloride and a preparation method thereof, which solves the problems of the prior art that the quantity of microspheres reaching the target site is small, thereby causing a large amount of drug waste, the therapeutic effect is no significant, the side effects of drugs are increased, and the possibility for generating drug resistance is high. In the technical scheme of the pulmonary targeting microsphere of veterinary ceftiofur hydrochloride, ceftiofur hydrochloride is used as a main component, poly-lactic-co-glycolic acid is used as a carrier material, and the mass ratio of the ceftiofur hydrochloride and the poly-lactic-co-glycolic acid is 1:1-1:50. The preparation method adopts the spray drying method. The particle sizes of the microspheres prepared in the method are relatively uniform, the large-scale preparation can be realized, the drug loading capacity and the encapsulation efficiency are both high, more than 89 percent of the particle sizes of the microspheres are all between 7mum and 30mum, thereby meeting the requirements of the pulmonary targeting microspheres for the particle sizes, and the microspheres can be concentrated in the lung, thereby enhancing the therapeutic effect.

The invention discloses a long-acting ceftiofur hydrochloride injection and a preparation method thereof. The long-acting ceftiofur hydrochloride injection of the invention is prepared from the following raw materials in percentage by weight: 10.2%-10.8% of ceftiofur hydrochloride, 2.0%-6.5% of additive and balance of soybean oil for injection. The long-acting ceftiofur hydrochloride injection of the invention can slowly release drug effect; the duration time of the blood drug concentration of the long-acting ceftiofur hydrochloride injection is 72-84 hours, which is greatly longer than the duration time of the blood drug concentration of the current ceftiofur hydrochloride injection; and compared with the conventional injection which needs to be injected once per day, the long-acting ceftiofur hydrochloride injection only needs to be injected once every 3 days and has good stability.

The invention discloses a long-acting compound ceftiofur suspension injection and its preparation technology. According to the invention, the compound ceftiofur suspension injection is prepared by using ceftiofur hydrochloride and tylosin tartrate as main drugs with assistance of appropriate auxiliary drugs. The suspension contains 5-20% (W/V) of ceftiofur hydrochloride, 5-20% (W/V) of tylosin tartrate, 0.5-2% (W/V) of a suspending agent, 0.01-0.5% (W/V) of an anti-oxidant, 0.1-3% (W/V) of a dispersant, and injection oil which is added to 100%. In comparison with a ceftiofur single preparation, the long-acting compound ceftiofur suspension injection has a strong antibacterial activity for Gram-negative bacteria and simultaneously has a strong effect of inhibiting Gram positive bacteria and mycoplasma. In addition, the preparation method provided by the invention provides a feasible approach for extended reproduction, and can be used to minimize times of drug administration and save manpower and material resources.

The invention relates to a method for preparing ceftiofur hydrochloride parenteral solution; the hydrochloride parenteral solution has the characteristics of even distribution and clear and transparent solution. The method comprises the following steps: (1) adding propylene glycol and ceftiofur hydrochloride with a volume equal to 60-70% of the total volume of ceftiofur hydrochloride parenteral solution to be prepared in a thick mixing tank; adding 2-10g ceftiofur hydrochloride for every 100ml of total volume of the ceftiofur hydrochloride parenteral solution; heating to 40-50 DEG C and stirring for rapid dissolving; (2) adding propylene glycol to reach the total volume of the ceftiofur hydrochloride parenteral solution to be prepared and cooling to 20-30 DEG C; (3) adding active carbon, stirring for 15-20 minutes and filtering; and (4) filling and sealing, sterilizing, light check and packing. The invention solves the problems of difficult and uneven injection of the ceftiofur hydrochloride parenteral solution of the existing technology and makes up the defects of easy-layer and inconvenient use of the ceftiofur hydrochloride suspension injection of the existing technology.

The invention discloses a compound ceftiofur suspension emulsion injection, which comprises the following components in percentage by mass: 1.5 to 15 percent of ceftiofur hydrochloride, 1.5 to 15 percent of magnolia flower oil, 1 to 10 percent of surfactant, 3 to 30 percent of oil for injection, 0.1 to 1 percent of antioxidant, 0.01 to 0.1 percent of thickening agent, and the balance of water for injection, wherein the sum of the mass percents of the components is 100 percent. The compound ceftiofur suspension emulsion injection has simple operation for the preparation method, strong antibacterial property and lasting pharmacological effect, and avoids stresses caused by multi-time administration of conventional formulations to animals; furthermore, the preparation cost is much lower than that of an oil suspension, and the compound ceftiofur suspension emulsion injection has a very high popularization and application value.

The invention belongs to the technical field of veterinary medicines, and particularly relates to a ceftiofur hydrochloride powder injection as well as a preparation method and an application thereof. The ceftiofur hydrochloride powder injection is prepared from the following effective components ceftiofur hydrochloride and a cosolvent at the weight ratio of (48-52) to (28-34). Ceftiofur sodium is replaced with the ceftiofur hydrochloride; veterinary cefepime hydrochloride powder injection is prepared by weighing the effective components and the cosolvent at the weight ratio of (48-52) to (28-34), mixing evenly, and sub-packaging; and the veterinary cefepime hydrochloride powder injection can be produced and stored at a room temperature. According to the ceftiofur hydrochloride powder injection, the problems that an existing veterinary cefepime hydrochloride powder injection needs to be produced by a freeze-drying method, the raw materials and the preparation need to be stored at a low temperature of 4-10 DEG C, the placement time in a room-temperature or high-temperature season is overlong, and the medication effect is poor due to degradation are solved; the prepared powder injection has the same antibacterial effect as a ceftiofur sodium freeze-dried powder injection; and the ceftiofur hydrochloride powder injection is low in cost and wide in application prospect.

The invention discloses an oil injection containing antibacterial agents/solid polyethylene glycol drug-loading particles. The oil injection is prepared by consisting of the drug-loading particles through antibacterial agents and solid polyethylene glycol and suspending the drug-loading particles in an oil medium. The antibacterial agents comprise enrofloxacin, danofloxacin mesylate, Marbofloxacin, mequindox, tilmicosin, tylosin, oxytetracycline hydrochloride, ceftiofur hydrochloride, cefquinome sulfate, lincomycin hydrochloride, florfenicol, erythrocin and doxycycline hydrochloride; preferentially the polyethylene glycol with the molecular weight of more than 6000 is used for preparing the preparation; more preferentially, any one of isopropyl myristate, soybean oil for injection, corn oil and tea-seed oil is used for preparing the preparation. Hydroxypropyl methyl cellulose or high-substituted hydroxy propyl cellulose can be added into the preparation.

The invention relates to a pharmaceutical composition used for preventing and treating colibacillosis in livestock and poultry. Every 100 g of the pharmaceutical composition comprises 2 to 10 g of ceftiofur hydrochloride, 0.25 to 10 g of tazobactam sodium, 5 to 10 g of probenecid sodium, 0.1 to 0.5 g of dexamethasone sodium phosphate and 2 to 15 g of beta-cyclodextrin, with the balance being pharmaceutically acceptable accessories. The pharmaceutical composition has the advantages of reasonable composition, low cost, a remarkable curative effect on clinical pathogenic escherichia coli, especially on drug-resistant intractable escherichia coli, a simple preparation method, stable properties and convenience in large scale intensive production.

The invention relates to the field of pharmaceutical preparations, in particular to a ceftiofur hydrochloride lipidosome injection and a preparation method thereof. The ceftiofur hydrochloride lipidosome injection contains ceftiofur hydrochloride, a buffer salt system, a lipidosome matrix, an additive and an antioxidant, and ceftiofur hydrochloride lipidosome is prepared through a high-pressure homogenization method. The lipidosome obtained through the method has the high encapsulation efficiency on ceftiofur hydrochloride and can achieve a slow releasing effect on medicine.

The invention provides ceftiofur hydrochloride injection for dairy cattle, comprising, by weight, 5-10 parts of ceftiofur hydrochloride, 0.5-3 parts of a suspending agent, 0.05-5 parts of a flocculant, 0.01-2 parts of an emulsifier, 0.1-2 parts of an antioxidant, and 55-100 parts of a lipid solvent. The ceftiofur hydrochloride injection has good dispersion stability and good needle passage, milk withdrawal period of dairy cattle injected with the ceftiofur hydrochloride injection is short, and the ceftiofur hydrochloride injection has a promising application prospect. A preparation method of the ceftiofur hydrochloride injection for dairy cattle is also provided; the preparation method is simple to perform and applicable to industrial application.

The invention discloses a method for preparing a ceftiofur hydrochloride suspension injection, which comprises the following steps: a) pulverizing ceftiofur hydrochloride in a pulverizer until the particle size of 90% particles is less than or equal to 20 mu m, and mixing; b) heating vegetable oil to 140-150 DEG C, keeping the temperature for 50-60 minutes for sterilization, and cooling to room temperature; c) adding the vegetable oil obtained in the step b) into the ceftiofur hydrochloride powder obtained in the step a), stirring uniformly, adding dehydrated sorbitol fatty acid ester, and continuing stirring uniformly until all the components are completely dispersed into a suspension; and d) refining the suspension obtained in the step c) with a homogenizer to obtain the ceftiofur hydrochloride suspension injection. Compared with the prior art, the method disclosed by the invention has the advantages of simple preparation technique, cheap and accessible raw and auxiliary materials, stable injection performance and obvious curative effect; compared with like products, the ceftiofur hydrochloride suspension injection has higher cost performance, and the product quality is superior to Relevant Standard for Pharmacopoeia, Edition 2010; and the invention is suitable for industrialized large-scale production, and therefore, has very wide application prospects.

The invention discloses a ceftiofur hydrochloride liposome lyophilized agent and a preparation method thereof. The ceftiofur hydrochloride liposome lyophilized agent comprises, by weight, 3-10 parts of ceftiofur hydrochloride, 15-100 parts of lecithin, 15-100 parts of cholesterols, and 4.5-13.5 parts of polyvinyl alcohol 2000. The preparation method comprises the following steps: dissolving ceftiofur hydrochloride, lecithin and cholesterols, mixing, carrying out vacuum drying, and adding a phosphate buffer solution of polyethylene glycol 2000 to prepare a liposome suspension; and adding a lyophilizing protection agent to the suspension, uniformly mixing, packaging the obtained solution to a penicillin bottle, putting the penicillin bottle provided with the solution in a lyophilizer, and drying to obtain the ceftiofur hydrochloride liposome-carried lyophilized agent. The liposome entrapment rate is good, and a result of long-term stabilization investigation of the liposome lyophilized agent shows that the stability of the liposome lyophilized agent is good; and the lyophilized agent re-dissolved in a liquid medium has the characteristics of good dispersion and stable properties. Clinic curative effect tests prove that compared with suspensions, the liposome lyophilized agent has the advantages of prolonged circulation time in an administrated body, and definite therapeutic effect on porcine respiratory diseases induced by bacterial infection.

The invention discloses a preparation method of a long-acting hydrochloric ceftiofur injection. The preparation method is characterized by including: using soybean oil as a solvent, heating the soybean oil to 140-150 DEG C, holding the temperature for 60min for sterilizing, and cooling to room temperature; dissolving or dispersing 0.5-2.0wt% of and 0.5-1.5wt% of according to prescription amounts in 70-80% of the sterilized solvent; guiding into a colloid mill for grinding, adding 10.2-10.8wt% of hydrochloric ceftiofur according to a prescription amount after grinding is finished, adopting a mode of alternating circulating grinding and non-circulating grinding for grinding, checking whether particle fineness reaches 2.5-5.0um or not, stopping grinding after requirements are met, and adding the sterilized solvent to the prescription amount to obtain an intermediate product; testing ceftiofur content and product character of the intermediate product, after passing needle drawing experiment, filling, externally packing, warehousing, and obtaining the injection after passing tests of content, sterility, granularity and related matter. Results show that when consumption of and is 1%, production process and product quality of the injection are stable.

The invention discloses a ceftiofur hydrochloride suspension injection, which is prepared, in every 100 mL of the injection, from 4-6 grams of ceftiofur hydrochloride, 1 to 5 grams of aluminum stearate, 0.01-0.2 gram of BHT (butylated hydroxytoluene), 0.01 to 0.03 gram of cecropin and the balance of injection-grade soybean oil. The ceftiofur hydrochloride suspension injection provided by the invention improves the solubility and the dissolution efficiency of a medicine, is low in sedimentation rate and good in dispersivity, improves the stability of a medicinal preparation, is high in drug loading capacity, decreases the dosing volume, increases biological safety, has quite good adhesivity with mucosal tissue, and realizes targeted drug delivery; moreover, after the cecropin is added, a drug effect of the ceftiofur hydrochloride suspension injection can be obviously enhanced.

The invention relates to preparation of a veterinary use chemical raw medicine and specifically relates to a preparation method of ceftiofur hydrochloride. Ceftiofur acid and AE active ester are used to synthetize ceftiofur in an organic solvent under the action of organic amine, a reaction liquid is extracted by water, hydrochloric acid is added after an aqueous phase extract liquid is decolorized to adjust potential of hydrogen (pH) to be 1-2, solid is separated out and filtered, a wet product is dissolved by an appropriate amount of acetone, water is slowly and dropwise added to elute crystals, filtering is performed, and the solid is dried to obtain the ceftiofur hydrochloride. According to the preparation method of the ceftiofur hydrochloride, the water is used as a crystallization solvent so that the organic solvent is reduced, reducing of production costs is facilitated, and environment pollution is reduced.

The invention provides a lung targeting microsphere of veterinary ceftiofur hydrochloride and a preparation method and can solve the problems of harmful toxic and side effects on a tissue due to the increased concentrations of other tissues caused by the low tissue selectivity of medicaments and poor therapeutic effect of the medicaments in the prior art. The lung targeting microsphere adopts the technical scheme of taking ceftiofur hydrochloride as a raw material and glutin as a carrier, wherein the weight ratio of the ceftiofur hydrochloride to the glutin is 1:3 to 30. The invention further provides the preparation method of the lung targeting microsphere. The lung targeting microsphere has the advantages of higher medicament loading rate and encapsulation rate of over 60 percent; after separation, the grain diameter of over 92 percent of the microsphere is between 7 and 30 mu m, so that the lung targeting microsphere meets the grain diameter requirement, improves the tissue selectivity, targets to the lung, reduces the concentrations of the medicaments in other tissues and toxic and side effects, and efficiently treats the pulmonary infection of animals.

The invention relates to magnesium ceftiofur, and belongs to the field of special curative activity of a compound or a pharmaceutical preparation. The magnesium ceftiofur is prepared by virtue of ceftiofur hydrochloride and medicinal oxidase, and the structural formula of the magnesium ceftiofur is provided. Meanwhile, the invention provides a preparation method and a using method of the magnesium ceftiofur; the magnesium ceftiofur disclosed by the invention has a same antibacterial activity as the ceftiofur hydrochloride and the magnesium ceftiofur has the properties of antibiotics; the action time of drugs can be prolonged through magnesium ions; meanwhile, the magnesium ceftiofur can supplement magnesium ions to a human body, so that the medicinal value of the magnesium ceftiofur is improved; and the magnesium ceftiofur disclosed by the invention is simple in preparation process, low in cost and applicable to industrial production.

The invention provides a compound especially used for inhibiting methionine aminopeptidase (MetAP) in mycobacterium tuberculosis (Mtb). The compound is ceftiofur hydrochloride, and possesses obvious inhibition activity on methionine aminopeptidase in mycobacterium tuberculosis. The compound can be used for preparing small molecular inhibitors used for inhibiting methionine aminopeptidase (MetAP) in mycobacterium tuberculosis (Mtb), and is promising to be prepared into drugs used for preventing Mtb infection.

The present invention relates to a ceftiofur hydrochloride and lincomycin hydrochloride compound cream and a preparation method thereof, wherein the cream comprises ceftiofur hydrochloride, lincomycin hydrochloride and other suitable materials, and during the preparation, a water phase and an oil phase are prepared, then the water phase is added to the oil phase to prepare a cream, and sterilization is performed.