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Ceftiofur hydrochloride suspension injection and method for preparing ceftiofur hydrochloride suspension injection

A technology of ceftiofur hydrochloride and suspension injection, which is applied in the directions of liquid delivery, pharmaceutical formulation, emulsion delivery, etc., can solve problems such as the limitation of the application of ceftiofur hydrochloride in water-insoluble injection, and achieves increased biological safety, The effect of good adhesion, improved solubility and dissolution efficiency

Active Publication Date: 2016-12-07
LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Injection is a commonly used dosage form. Compared with other dosage forms, injection has fast onset of action, accurate dosage, reliable effect, and is not affected by various factors in the gastrointestinal tract. Individuals who take oral administration and drugs that cannot be taken orally; but the non-water solubility of ceftiofur hydrochloride brings great limitations to injection applications

Method used

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  • Ceftiofur hydrochloride suspension injection and method for preparing ceftiofur hydrochloride suspension injection
  • Ceftiofur hydrochloride suspension injection and method for preparing ceftiofur hydrochloride suspension injection
  • Ceftiofur hydrochloride suspension injection and method for preparing ceftiofur hydrochloride suspension injection

Examples

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Embodiment 1

[0010] A suspension injection of ceftiofur hydrochloride, containing in every 100mL injection: 4-6g of ceftiofur hydrochloride, 1-5g of aluminum stearate, 0.01-0.2g of BHT (dibutylhydroxytoluene), cecropin antibacterial Peptide 0.01-0.03g, the rest is injection grade soybean oil.

[0011] The above-mentioned preparation method of ceftiofur hydrochloride suspension injection comprises the following steps: adding aluminum stearate into soybean oil and heating to dissolve, dispersing the foam, controlling the oil temperature at about 120°C to form a light yellow viscous Add BHT after turning into a clear liquid, stir to dissolve, add ceftiofur hydrochloride after cooling, stir and mix, then add cecropin antimicrobial peptide, stir and mix, add injection-grade soybean oil to the full amount, stir and mix, homogeneous, pressure 30Mpa, Check that the semi-finished product is qualified, then pack it, cover it, label it, and pack it. During the entire production process, aseptic oper...

Embodiment 2

[0015] A suspension injection of ceftiofur hydrochloride, which contains 5 g of ceftiofur hydrochloride, 3 g of aluminum stearate, 0.1 g of BHT, 0.02 g of cecropin antimicrobial peptide, and the rest is injection-grade soybean oil per 100 mL of injection. All the other are with embodiment 1.

[0016] The formula of Ceftiofur Hydrochloride Suspension Injection in Example 3-16 of the present invention is shown in Table 1-2, and the others are the same as in Example 2.

[0017]

[0018]

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Abstract

The invention discloses a ceftiofur hydrochloride suspension injection, which is prepared, in every 100 mL of the injection, from 4-6 grams of ceftiofur hydrochloride, 1 to 5 grams of aluminum stearate, 0.01-0.2 gram of BHT (butylated hydroxytoluene), 0.01 to 0.03 gram of cecropin and the balance of injection-grade soybean oil. The ceftiofur hydrochloride suspension injection provided by the invention improves the solubility and the dissolution efficiency of a medicine, is low in sedimentation rate and good in dispersivity, improves the stability of a medicinal preparation, is high in drug loading capacity, decreases the dosing volume, increases biological safety, has quite good adhesivity with mucosal tissue, and realizes targeted drug delivery; moreover, after the cecropin is added, a drug effect of the ceftiofur hydrochloride suspension injection can be obviously enhanced.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug processing, and in particular relates to a ceftiofur hydrochloride suspension injection and a preparation method thereof. Background technique [0002] Ceftiofur is a third-generation cephalosporin antibiotic specially used for animals. It is insoluble in water, slightly soluble in acetone, and almost insoluble in ethanol. It is often made into sodium salt or hydrochloride for injection. It has a broad spectrum Bactericidal effect on Gram-positive and Gram-negative strains including lactamase-producing strains. Sensitive bacteria include Pasteurella, Actinobacillus, Salmonella, Streptococcus, Staphylococcus, etc. Its antibacterial activity is better than that of ampicillin Strong, the activity against streptococci is also stronger than quinolone antibacterial drugs. [0003] Injection is a commonly used dosage form. Compared with other dosage forms, injection has fast onset of action, acc...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/546A61K38/17A61K47/12A61P31/04
CPCA61K9/0019A61K9/10A61K31/546A61K38/17A61K47/12A61K2300/00
Inventor 郭文江吴保庆何涛常鹏艳刘扬科娄亚坤
Owner LINZHOU SINAGRI YINGTAI BIOLOGICAL PEPTIDES CO LTD
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